Images in Dermatology
Azithromycin for the Treatment of Ciclosporin-Induced Gingival Hyperplasia
Utilidad de la azitromicina en la hiperplasia gingival inducida por ciclosporina
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"apellidos" => "Jordá" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital Clínico Universitario, Valencia, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Departamento de Medicina, Universidad de Valencia, Valencia, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Medicina Interna, Hospital Universitario Dr. Peset, Valencia, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Utilidad de la azitromicina en la hiperplasia gingival inducida por ciclosporina" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:6 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 507 "Ancho" => 1500 "Tamanyo" => 123966 ] ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Our patient was a 33-year-old woman who had received allogenic stem cell transplant for hepatosplenic T-cell lymphoma. She was administered ciclosporin, 150<span class="elsevierStyleHsp" style=""></span>mg/d, as prophylaxis for graft-versus-host disease and developed progressive gingival hyperplasia, most evident 2 months after starting treatment (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1A</a>). She was then administered azithromycin, 500<span class="elsevierStyleHsp" style=""></span>mg daily for 3 days, which produced a considerable improvement at 3 weeks (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1B</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">Gingival hyperplasia is a known complication of treatment with ciclosporin. It occurs in approximately 30% of cases, but its pathogenesis remains unknown. The mechanism of action of azithromycin is not fully understood, but it has been suggested that the drug may have a triple action in the resolution of certain periodontal diseases, due to its antimicrobial and anti-inflammatory activity and its capacity to persist at low concentrations in the macrophages and fibroblasts of the periodontal tissues, even when administered in short-term regimens of 3 to 5 days.</p><p id="par0015" class="elsevierStylePara elsevierViewall">In more prolonged treatments, the interaction that occurs between the 2 drugs would require ciclosporin levels to be monitored and great care to be taken in patients with alterations of cardiac repolarization.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Martín JM, Mateo E, Jordá E. Utilidad de la azitromicina en la hiperplasia gingival inducida por ciclosporina. Actas Dermosifiliogr. 2016;107:780.</p>" ] ] "multimedia" => array:1 [ 0 => array:6 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 507 "Ancho" => 1500 "Tamanyo" => 123966 ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010700000009/v1_201611010039/S1578219016302074/v1_201611010039/en/main.assets" "Apartado" => array:4 [ "identificador" => "41141" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Images in Dermatology" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010700000009/v1_201611010039/S1578219016302074/v1_201611010039/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219016302074?idApp=UINPBA000044" ]
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