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2</a>B&#41;&#46; Immunohistochemical staining for <span class="elsevierStyleItalic">Treponema pallidum</span> was positive &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>C&#41;&#46; Syphilis serology was requested&#59; the nontreponemal rapid plasma reagin &#40;RPR&#41; test showed antibody titers of 1&#47;128 and the treponemal antibody test was positive&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">The second man&#44; aged 29 years&#44; had been diagnosed with HIV infection in 2011 and had achieved good immunologic control without pharmacologic treatment&#46; He presented with mildly pruritic scrotal lesions of 1 month&#39;s duration&#46; The lesions had been diagnosed as eczema and treated with topical corticosteroids&#44; but there had been no improvement&#46; The physical examination showed numerous pink plaques with a lichenoid appearance on the scrotum and at the base of the penis &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; Laboratory tests&#44; including biochemistry&#44; a complete blood count&#44; and coagulation studies&#44; showed no alterations&#44; and serology for syphilis was also negative&#46; Histologic examination of a skin biopsy sample showed lichenoid dermatitis and immunohistochemical staining was positive for <span class="elsevierStyleItalic">T&#160;pallidum</span>&#46; The RPR test was positive &#40;titer&#44; 1&#47;64&#41;&#44; as were the enzyme-linked immunosorbent assay and hemagglutination results&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Both patients were diagnosed with secondary syphilis mimicking lichen planus&#44; with exclusive genital involvement&#46; The clinical outcome was satisfactory in both cases&#44; with complete resolution of lesions following treatment with intramuscular benzathine penicillin G 2&#46;4 million units and a decline in RPR titers&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Cutaneous manifestations of secondary syphilis appear 3 to 12 weeks after the onset of the primary chancre&#44; although they can occur months later or even before this sore disappears&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">2</span></a> Secondary syphilis typically presents as maculopapular and erythematous scaling lesions&#44; although lichenoid&#44; nodular&#44; and ulcerated lesions may also be observed&#44; though less frequently&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">3&#44;4</span></a> HIV infection accelerates the progression of syphilis by altering cell-mediated immunity&#44; and it is sometimes associated with atypical syphilis manifestations&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">4</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Known as the <span class="elsevierStyleItalic">great imitator</span>&#44; syphilis is a true diagnostic challenge for clinicians&#46; Although secondary syphilis is known to mimic other diseases &#40;pityriasis rosea&#44; psoriasis&#44;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">5</span></a> sarcoidosis&#44; etc&#46;&#41;&#44; lichenoid eruptions are uncommon&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">6</span></a> These eruptions were reported prior to the introduction of penicillin&#44; i&#46;e&#46;&#44; when arsenic-based compounds were still being used as the treatment of choice for syphilis&#44; and it was assumed that these compounds for responsible for the lichenoid appearance of the lesions&#46; Similar lesions&#44; however&#44; continued to be observed when they were replaced with penicillin&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">7</span></a> Serology&#44; together with histologic findings&#44; has an important diagnostic role&#44; with positive results shown by both treponemal and nontreponemal tests&#46; Most patients with HIV infection have normal serology&#44; although they may present false-positive nontreponemal responses and higher-than-expected titers in the absence of reinfection&#46; It should also be noted that delayed positives and false negatives are also possible with nontreponemal tests&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The treatment of secondary syphilis in patients with HIV infection has generated some controversy&#46; The latest edition of the Sexually Transmitted Diseases Treatment Guidelines from the Centers for Disease Control<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">8</span></a> recommends a single dose of intramuscular benzathine penicillin G 2&#46;4 million units&#44; regardless of whether the patient has concomitant HIV infection or not&#44; as additional doses have not proven to be more effective&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Although the literature contains reports of secondary syphilis mimicking lichen planus&#44; our cases are interesting in that the lesions were exclusively genital&#46; We found only 2 similar cases in our literature search&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">9</span></a> Both clinicians and pathologists should be aware of the highly variable clinical and histologic features of secondary syphilis to ensure prompt diagnosis and treatment&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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Case and Research Letter
Secondary Syphilis Mimicking Lichen Planus in a Patient With HIV Coinfection
Sífilis secundaria simulando liquen plano en el paciente con infección por VIH
N. Jiménez-Gómeza,
Corresponding author
natjgomez@gmail.com

Corresponding author.
, Á. Hermosa-Gelbarda, R. Carrillo-Gijónb, P. Jaéna
a Servicio de Dermatología, Hospital Universitario Ramón y Cajal, Madrid, Spain
b Servicio de Anatomía Patológica, Hospital Universitario Ramón y Cajal, Madrid, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Syphilis rates have been on the rise in recent years&#46; In Spain&#44; this sexually transmitted infection mainly affects men who have sex with men &#40;MSM&#41;&#44; many of whom are coinfected with human immunodeficiency virus &#40;HIV&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a> The natural history of both syphilis and HIV infection is affected by the coexistence of these diseases&#46; The clinical manifestations of syphilis can progress more rapidly in patients with concomitant HIV infection&#44; and aggressive and atypical forms of syphilis are also more common in this population&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We report the case of 2 MSM with HIV infection who visited their dermatologist with genital lesions&#46; The first man&#44; aged 35 years&#44; reported slightly pruritic lesions on the genitals that had appeared a month and a half earlier&#46; He had applied topical corticosteroids&#44; but there had been no improvement&#46; Good immunologic control of his HIV infection had been maintained since 2009 without antiretroviral therapy&#46; The physical examination revealed erythematous plaques with a lichenoid appearance and a tendency to coalesce on the dorsal aspect of the penis &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a> A and B&#41;&#46; Blood test results brought by the patient&#44; which included biochemistry&#44; a complete blood count&#44; and coagulation studies&#44; were unremarkable&#46; Skin biopsy revealed lichenoid dermatitis with effacement of the basal layer&#44; exocytosis of neutrophils&#44; and a band-like lymphoplasmacytic infiltrate &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>A&#41;&#46; Numerous plasma cells were also observed on the wall and around the vessels of the dermis &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>B&#41;&#46; Immunohistochemical staining for <span class="elsevierStyleItalic">Treponema pallidum</span> was positive &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>C&#41;&#46; Syphilis serology was requested&#59; the nontreponemal rapid plasma reagin &#40;RPR&#41; test showed antibody titers of 1&#47;128 and the treponemal antibody test was positive&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">The second man&#44; aged 29 years&#44; had been diagnosed with HIV infection in 2011 and had achieved good immunologic control without pharmacologic treatment&#46; He presented with mildly pruritic scrotal lesions of 1 month&#39;s duration&#46; The lesions had been diagnosed as eczema and treated with topical corticosteroids&#44; but there had been no improvement&#46; The physical examination showed numerous pink plaques with a lichenoid appearance on the scrotum and at the base of the penis &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; Laboratory tests&#44; including biochemistry&#44; a complete blood count&#44; and coagulation studies&#44; showed no alterations&#44; and serology for syphilis was also negative&#46; Histologic examination of a skin biopsy sample showed lichenoid dermatitis and immunohistochemical staining was positive for <span class="elsevierStyleItalic">T&#160;pallidum</span>&#46; The RPR test was positive &#40;titer&#44; 1&#47;64&#41;&#44; as were the enzyme-linked immunosorbent assay and hemagglutination results&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Both patients were diagnosed with secondary syphilis mimicking lichen planus&#44; with exclusive genital involvement&#46; The clinical outcome was satisfactory in both cases&#44; with complete resolution of lesions following treatment with intramuscular benzathine penicillin G 2&#46;4 million units and a decline in RPR titers&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Cutaneous manifestations of secondary syphilis appear 3 to 12 weeks after the onset of the primary chancre&#44; although they can occur months later or even before this sore disappears&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">2</span></a> Secondary syphilis typically presents as maculopapular and erythematous scaling lesions&#44; although lichenoid&#44; nodular&#44; and ulcerated lesions may also be observed&#44; though less frequently&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">3&#44;4</span></a> HIV infection accelerates the progression of syphilis by altering cell-mediated immunity&#44; and it is sometimes associated with atypical syphilis manifestations&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">4</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Known as the <span class="elsevierStyleItalic">great imitator</span>&#44; syphilis is a true diagnostic challenge for clinicians&#46; Although secondary syphilis is known to mimic other diseases &#40;pityriasis rosea&#44; psoriasis&#44;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">5</span></a> sarcoidosis&#44; etc&#46;&#41;&#44; lichenoid eruptions are uncommon&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">6</span></a> These eruptions were reported prior to the introduction of penicillin&#44; i&#46;e&#46;&#44; when arsenic-based compounds were still being used as the treatment of choice for syphilis&#44; and it was assumed that these compounds for responsible for the lichenoid appearance of the lesions&#46; Similar lesions&#44; however&#44; continued to be observed when they were replaced with penicillin&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">7</span></a> Serology&#44; together with histologic findings&#44; has an important diagnostic role&#44; with positive results shown by both treponemal and nontreponemal tests&#46; Most patients with HIV infection have normal serology&#44; although they may present false-positive nontreponemal responses and higher-than-expected titers in the absence of reinfection&#46; It should also be noted that delayed positives and false negatives are also possible with nontreponemal tests&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The treatment of secondary syphilis in patients with HIV infection has generated some controversy&#46; The latest edition of the Sexually Transmitted Diseases Treatment Guidelines from the Centers for Disease Control<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">8</span></a> recommends a single dose of intramuscular benzathine penicillin G 2&#46;4 million units&#44; regardless of whether the patient has concomitant HIV infection or not&#44; as additional doses have not proven to be more effective&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Although the literature contains reports of secondary syphilis mimicking lichen planus&#44; our cases are interesting in that the lesions were exclusively genital&#46; We found only 2 similar cases in our literature search&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">9</span></a> Both clinicians and pathologists should be aware of the highly variable clinical and histologic features of secondary syphilis to ensure prompt diagnosis and treatment&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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