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C) La biopsia de una mácula pigmentada en tronco muestra junto con la arquitectura del nevus epidérmico una hiperplasia de los melanocitos en la unión dermoepidérmica tratándose de un nevus melanocítico lentiginoso de unión sin atipia citológica (H&E ×10).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "D. Ayala, M.D. Ramón, J.M. Martín, E. Jordá" "autores" => array:4 [ 0 => array:2 [ "nombre" => "D." "apellidos" => "Ayala" ] 1 => array:2 [ "nombre" => "M.D." "apellidos" => "Ramón" ] 2 => array:2 [ "nombre" => "J.M." "apellidos" => "Martín" ] 3 => array:2 [ "nombre" => "E." 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Ayala, M.D. Ramón, J.M. Martín, E. Jordá" "autores" => array:4 [ 0 => array:4 [ "nombre" => "D." "apellidos" => "Ayala" "email" => array:1 [ 0 => "dayalca83@hotmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "M.D." "apellidos" => "Ramón" ] 2 => array:2 [ "nombre" => "J.M." "apellidos" => "Martín" ] 3 => array:2 [ "nombre" => "E." "apellidos" => "Jordá" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Dermatología, Hospital Clínico Universitario de Valencia, Valencia, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Facomatosis pigmentoqueratótica atípica como expresión de rasopatía en mosaicismo con mutación en gen BRAF Glu586Lys" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1132 "Ancho" => 1500 "Tamanyo" => 426399 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A, Inflammatory lesions over the epidermal nevus on the trunk and left upper limb. The lesions presented as round and oval plaques with a psoriasiform appearance. B, Patchy distribution of the inflammatory lesions on the patient's back, not affecting some areas of the epidermal nevus. C, Biopsy of 1 of the lesions showed epidermal nevus architecture with acanthosis and papillomatosis, associated with a lymphocytic infiltrate in the superficial dermis (arrow). Hematoxylin and eosin, original magnification<span class="elsevierStyleHsp" style=""></span>×10. D, Area of parakeratosis with mild spongiosis. Hematoxylin and eosin, original magnification<span class="elsevierStyleHsp" style=""></span>×20.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The epidermal nevus syndromes are a group of conditions in which any type of epidermal nevus is associated with extracutaneous changes. The most common associated alterations are skeletal, neurologic, and ophthalmic.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Our patient was a 37-year-old woman with a systematized epidermal nevus, present since birth and affecting the left side of the body. The nevus was formed of brownish papillomatous plaques with a characteristic distribution along the Blaschko lines (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). She also presented a plaque of alopecia in the temporal region, hyperkeratotic lesions on the left hand, and ipsilateral plantar keratoderma. These findings were associated with multiple musculoskeletal alterations, including marked scoliosis, dysmetria of the hips with atrophy of the left lower limb, painful joint disease affecting the interphalangeal joints of the right hand, and vascular alterations consisting of bilateral chronic lymphedema of the lower limbs secondary to insufficiency of the internal saphenous vein. Neurologically, the patient presented paralysis of the left third cranial nerve, with no evidence of other cerebral abnormalities. In addition, for the previous 7 years she had presented outbreaks of inflammatory lesions in the area of the epidermal nevus, with no apparent cause. These lesions were formed of round or oval plaques with a psoriasiform appearance and a patchy distribution; they improved with topical corticosteroids. Biopsy of 1 of these lesions revealed verrucous epidermal nevus architecture with acanthosis and papillomatous, associated with a lymphocytic infiltrate in the superficial dermis and alternating areas of parakeratosis with mild spongiosis and areas of orthokeratosis (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). For the previous several years, our patient had also presented pigmented macules that developed progressively on the underlying epidermal nevus, in a clearly linear distribution on the trunk and on the left limbs. Biopsy of 1 of the pigmented lesions showed epidermal nevus architecture together with junctional melanocyte hyperplasia, indicating the presence of a junctional lentiginous nevus with no atypia (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">In 2010, Happle<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">2</span></a> described 9 well-defined epidermal nevus syndromes; our case presents greatest similarity with phacomatosis pigmentokeratotica. This disease is defined as the combination of an epidermal nevus with sebaceous differentiation with a nevus Spilus, associated with extracutaneous changes. However, atypical variants of phacomatosis pigmentokeratotica have been described, in which the epidermal nevus is verrucous and does not show sebaceous differentiation<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">3,4</span></a>; our patient presented this variant. It must be understood that this is not a definitive classification, and further entities based on clinical and molecular criteria will be described in coming years.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">5</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Regarding the inflammatory plaques on the epidermal nevus, we considered a differential diagnosis including inflammatory linear verrucous epidermal nevus (ILVEN). ILVEN is a variant of epidermal nevus that typically appears in young children,<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">6</span></a> presenting as pruritic inflammatory plaques that can be similar to linear psoriasis.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">7</span></a> The distribution of the lesions in our case differed from that observed in ILVEN, as the round or oval inflammatory plaques appeared in patches, leaving areas of epidermal nevus unaffected, and the outbreaks always arose in the same areas of the epidermal nevus. This particular distribution has not previously been described and suggests that there may be some molecular alteration in the keratinocytes of the inflamed areas of the epidermal nevus that would trigger a localized immune response, a hypothesis supported by the finding on histopathology of a lymphocytic infiltrate in the superficial dermis.</p><p id="par0025" class="elsevierStylePara elsevierViewall">We hypothesize that the late appearance of the melanocytic nevus on the epidermal nevus in our patient was due to a mutation in the melanocytes that had remained silent until adult life, when expression occurred in mosaic form, following the path of the epidermal nevus. The linear distribution of the lesions and the extracutaneous alterations involving a number of cell lines suggests an early postzygotic mutation. Recently, postzygotic gene mutations have been described in the RAS-MAPK (mitogen-activated protein kinase) pathway, interpreting the epidermal nevus syndromes as RASopathies expressed as cutaneous mosaicism.<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">8,9</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">In our patient, the genetic analysis performed on a sample of epidermal nevus revealed a <span class="elsevierStyleItalic">BRAF-</span>Glu586Lys mutation (exon 15). The genetic analysis was completed on a sample of healthy skin and of melanocytic nevus, finding no alterations, a circumstance that further supports the hypothesis that the mutation described in the epidermal nevus is not a casual finding. Although this alteration has not been described in the context of epidermal nevus,<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">9</span></a> the pathogenicity of the <span class="elsevierStyleItalic">BRAF</span>-Glu586Lys mutation has been demonstrated in in vitro experimental models.<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">10</span></a> The substitution of glutamate for lysine at position 586 of the amino acid chain produces a structural change that increases the activity of the BRAF protein.<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">10</span></a> It should be remembered that the RAS-MAPK pathway participates in cell differentiation, growth, and death. It is involved in up to 20% to 30% of somatic cancers, and the majority of mutations provoke pathway upregulation,<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">11</span></a> as in our case.</p><p id="par0035" class="elsevierStylePara elsevierViewall">In conclusion, we have described an atypical case of phacomatosis pigmentokeratotica that presented as outbreaks of inflammatory lesions on the epidermal nevus, with a distinctive distribution, associated with the progressive appearance of melanocytic nevi distributed along the Blaschko lines. The genetic analysis revealed a mutation in the <span class="elsevierStyleItalic">BRAF</span> gene not previously described in the literature in relation to epidermal nevus, making this a RASopathy expressed in mosaicism.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0040" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflicts of Interest" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Ayala D, Ramón MD, Martín JM, Jordá E. Facomatosis pigmentoqueratótica atípica como expresión de rasopatía en mosaicismo con mutación en gen BRAF Glu586Lys. Actas Dermosifiliogr. 2016;107:345–347.</p>" ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 479 "Ancho" => 1500 "Tamanyo" => 124851 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A and B, Systematized epidermal nevus affecting the left side of the body, presenting as brownish papillomatous plaques distributed along the Blaschko lines. C, Hip asymmetry with atrophy of the left gluteus and bilateral chronic lymphedema secondary to insufficiency of the internal saphenous vein.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1132 "Ancho" => 1500 "Tamanyo" => 426399 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A, Inflammatory lesions over the epidermal nevus on the trunk and left upper limb. The lesions presented as round and oval plaques with a psoriasiform appearance. B, Patchy distribution of the inflammatory lesions on the patient's back, not affecting some areas of the epidermal nevus. C, Biopsy of 1 of the lesions showed epidermal nevus architecture with acanthosis and papillomatosis, associated with a lymphocytic infiltrate in the superficial dermis (arrow). Hematoxylin and eosin, original magnification<span class="elsevierStyleHsp" style=""></span>×10. D, Area of parakeratosis with mild spongiosis. Hematoxylin and eosin, original magnification<span class="elsevierStyleHsp" style=""></span>×20.</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1125 "Ancho" => 1500 "Tamanyo" => 327112 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A and B, Pigmented macular lesions on the epidermal nevus in a linear distribution on the trunk and left upper limb. C, Biopsy of a pigmented macule on the trunk showed epidermal nevus architecture associated with junctional melanocyte hyperplasia, indicating the presence of a junctional lentiginous melanocytic nevus with no atypia. Hematoxylin and eosin, original magnification<span class="elsevierStyleHsp" style=""></span>×10).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:11 [ 0 => array:3 [ "identificador" => "bib0060" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidermal nevus syndromes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.L. 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2024 October | 66 | 35 | 101 |
2024 September | 103 | 29 | 132 |
2024 August | 131 | 78 | 209 |
2024 July | 92 | 37 | 129 |
2024 June | 100 | 27 | 127 |
2024 May | 76 | 28 | 104 |
2024 April | 65 | 27 | 92 |
2024 March | 65 | 29 | 94 |
2024 February | 55 | 31 | 86 |
2024 January | 60 | 37 | 97 |
2023 December | 63 | 17 | 80 |
2023 November | 90 | 29 | 119 |
2023 October | 87 | 24 | 111 |
2023 September | 80 | 41 | 121 |
2023 August | 61 | 13 | 74 |
2023 July | 80 | 34 | 114 |
2023 June | 62 | 28 | 90 |
2023 May | 54 | 26 | 80 |
2023 April | 69 | 23 | 92 |
2023 March | 64 | 20 | 84 |
2023 February | 84 | 21 | 105 |
2023 January | 44 | 28 | 72 |
2022 December | 61 | 43 | 104 |
2022 November | 42 | 21 | 63 |
2022 October | 31 | 28 | 59 |
2022 September | 47 | 40 | 87 |
2022 August | 31 | 32 | 63 |
2022 July | 27 | 39 | 66 |
2022 June | 29 | 20 | 49 |
2022 May | 38 | 46 | 84 |
2022 April | 49 | 20 | 69 |
2022 March | 40 | 42 | 82 |
2022 February | 36 | 25 | 61 |
2022 January | 53 | 36 | 89 |
2021 December | 40 | 32 | 72 |
2021 November | 64 | 40 | 104 |
2021 October | 61 | 40 | 101 |
2021 September | 34 | 45 | 79 |
2021 August | 37 | 25 | 62 |
2021 July | 36 | 25 | 61 |
2021 June | 35 | 30 | 65 |
2021 May | 31 | 41 | 72 |
2021 April | 98 | 47 | 145 |
2021 March | 55 | 37 | 92 |
2021 February | 52 | 25 | 77 |
2021 January | 30 | 21 | 51 |
2020 December | 42 | 26 | 68 |
2020 November | 23 | 18 | 41 |
2020 October | 30 | 22 | 52 |
2020 September | 39 | 16 | 55 |
2020 August | 22 | 24 | 46 |
2020 July | 24 | 21 | 45 |
2020 June | 30 | 32 | 62 |
2020 May | 19 | 12 | 31 |
2020 April | 31 | 23 | 54 |
2020 March | 21 | 13 | 34 |
2020 February | 6 | 0 | 6 |
2020 January | 6 | 0 | 6 |
2019 December | 7 | 0 | 7 |
2019 November | 4 | 0 | 4 |
2019 September | 6 | 0 | 6 |
2019 August | 4 | 0 | 4 |
2019 July | 4 | 0 | 4 |
2019 June | 4 | 0 | 4 |
2019 May | 7 | 1 | 8 |
2019 April | 2 | 1 | 3 |
2019 March | 2 | 3 | 5 |
2019 February | 4 | 0 | 4 |
2019 January | 5 | 0 | 5 |
2018 November | 1 | 0 | 1 |
2018 October | 5 | 0 | 5 |
2018 September | 1 | 0 | 1 |
2018 February | 22 | 3 | 25 |
2018 January | 43 | 7 | 50 |
2017 December | 45 | 5 | 50 |
2017 November | 31 | 3 | 34 |
2017 October | 22 | 8 | 30 |
2017 September | 26 | 4 | 30 |
2017 August | 23 | 7 | 30 |
2017 July | 19 | 11 | 30 |
2017 June | 27 | 8 | 35 |
2017 May | 25 | 3 | 28 |
2017 April | 16 | 6 | 22 |
2017 March | 17 | 26 | 43 |
2017 February | 18 | 7 | 25 |
2017 January | 15 | 5 | 20 |
2016 December | 21 | 26 | 47 |
2016 November | 23 | 15 | 38 |
2016 October | 31 | 14 | 45 |
2016 September | 0 | 5 | 5 |
2016 July | 1 | 2 | 3 |
2016 June | 0 | 4 | 4 |
2016 May | 0 | 7 | 7 |