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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Lipoblastoma is a benign adipocytic tumor consisting of lobulated&#44; immature white fat cells with a prominent capillary pattern and&#44; frequently&#44; a focal myxoid matrix&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> The tumor can be localized or diffuse&#44; occurs predominantly in infancy and early childhood&#44; and affects patients aged 5 years or younger in 84&#37; of cases&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> Nevertheless&#44; rare cases have been reported in adolescents and adults&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3&#44;4</span></a> Most lipoblastomas are subcutaneous lesions affecting the arms and legs&#44; and they are more common in male patients&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We report the case of a distinctive mesenchymal neoplasm of the lip showing adipocytic differentiation in an adult woman&#46; We consider that this tumor is akin to infantile lipoblastoma&#46; As far as we are aware&#44; only 1 such lesion has been previously reported&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">A 36-year-old woman presented with a history of a small asymptomatic&#44; pigmented&#44; raised nodule on the vermilion border of the lower lip that had been present for about 9 months&#46; The patient had not undergone lip piercing&#44; filler injection for lip augmentation&#44; or any other interventions&#46; Her past medical history was not significant for systemic disease&#46; Physical examination revealed a soft&#44; brown-colored&#44; sessile nodule measuring 0&#46;8<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>0&#46;4<span class="elsevierStyleHsp" style=""></span>cm on the right half of the lower lip&#46; The clinical diagnosis was melanocytic nevus&#46; The lesion was completely removed&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The microscopic study showed a poorly demarcated lesion&#44; with epidermal acanthosis&#44; irregular papillomatosis&#44; and hyperpigmentation of the basal layer&#46; Scattered aggregates of immature fat cells replaced much of the submucosa &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#44; with a preferential perivascular location&#46; These cells showed variation in size and were multivacuolated lipoblasts&#44; which indented the nuclei and were interspersed with univacuolated lipoblasts that displaced the nuclei and looked like signet-ring fat cells&#46; Mature adipocytes were scant &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Hibernoma-like cells were not seen&#46; All the nuclei were small and monomorphic without atypia&#46; Mitotic figures were absent&#46; No giant cells&#44; lymphocytes&#44; mucin deposits&#44; or plexiform vascularization were observed&#46; Dermal aggregates were surrounded by numerous small vessels&#44; and were incompletely separated by the thick collagenous bundles of dermis&#46; In the depth of the lesion&#44; lipoblast aggregates were seen to form part of the adventitia of small veins or to infiltrate between the fascicles of the orbicularis muscle &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; No birefringence was observed in the adipocytic cells&#46; Alcian blue &#40;pH 2&#46;5&#41; did not show any acid mucin in the fat cell groups or in the dermal connective tissue&#46; The cells stained positively for vimentin and retinoblastoma antibody and negatively for AE1&#47;AE3 cytokeratin&#44; CD34&#44; CD31&#44; CD68&#44; and estrogen receptor&#46; Immature adipocytes showed moderate amounts of cytoplasmic mitochondria around fat vacuoles that were visible with the antimitochondrial antibody&#46; The amount of mitochondria was not comparable to that observed in the brown adipose tissue cells&#46; The neoplasm involved the surgical margins&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">There has been no local recurrence or metastasis in the 9 months since surgery&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The tumor in the case reported here shared histological features with lipoblastoma&#44; namely prominent lobulation&#44; immature fat cells consisting of multivacuolated and univacuolated lipoblasts admixed with mature fat cells&#44; conspicuous capillaries&#44; variably developed collagenous septae&#44; and diffuse borders&#46; The clinical manifestations suggested a diagnosis of melanocytic nevus due to the concomitant pigmented epidermal lesion&#46; We interpret the epidermal lesion as a reactive hyperplasia that may accompany lesions of this kind&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Lipoblastoma occurs primarily in infancy and early childhood&#44; but it can be observed in adolescents and young adults&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> Lae et al&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> described 2 cases in women aged 23 and 38 years&#44; and Silverman et al&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> reported a recurring lipoblastoma in a 48-year-old man&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">To our knowledge&#44; the present case is the second report of a lipoblastoma-like tumor of the lip&#46; Jeong et al&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> reported a similar intradermal lesion involving the lower lip of a 61-year-old woman&#46; The dermal tumor was erythematous&#44; slightly elevated&#44; and measured 2<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>1<span class="elsevierStyleHsp" style=""></span>cm&#46; The clinical differential diagnosis included Fordyce spot&#44; nevus lipomatosus superficialis&#44; and foreign body granuloma&#46; The excised specimen showed abundant dermal lobules composed of lipoblasts and mature cells&#46; The epidermis above the dermal tumor showed acanthosis and irregular papillomatosis&#44; which is a change similar to that observed in the case we are reporting&#46; Neither local recurrence nor metastasis was observed 1 year after surgery&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Lipoblastoma is a benign tumor&#44; but it can return in 9&#37; of cases&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> Recurrence may occur in the form of a mature lipomatous tumor&#46; The differential diagnosis includes other dermal tumors with lipoblasts such as atypical lipomatous tumor&#47;well-differentiated liposarcoma&#44; spindle cell&#47;pleomorphic lipoma&#44; and myxoid liposarcoma&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">The nature of lipoblastoma remains to be explained&#46; The structure of the lesion is reminiscent of the development of white adipose tissue&#46; White embryonal&#47;fetal fat is characterized by a very close association between adipocyte development and angiogenesis&#46; Both small univacuolated and multivacuolated adipocytes form lobules with abundant delicate branching capillaries&#46; It has been proposed that the white adipocyte precursor is derived from undifferentiated mesenchymal cells that reside in the mural cell compartment of the adipose vasculature&#46;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">8&#8211;10</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">The embryonal&#47;fetal structure of the lipoblastoma and its occurrence primarily in the very young suggests a hamartomatous lesion&#46;</p></span>"
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Case and Research Letter
Intradermal Lipoblastoma-Like Tumor of the Lip in an Adult Woman
Lipoblastoma intradérmico tumor tipo en el labio de una mujer adulta
J.F. Val-Bernal
Corresponding author
apavbj@humv.es

Corresponding author.
, S. Hermana, R. Sánchez
Department of Anatomical Pathology, Marqués de Valdecilla University Hospital, Medical Faculty, University of Cantabria and IDIVAL, Santander, Spain
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          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Multivacuolated and univacuolated lipoblasts constitute most of the dermal fat tissue&#46; Mature adipocytes are scant &#40;hematoxylin and eosin&#44; original magnification &#215;200&#41;&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Lipoblastoma is a benign adipocytic tumor consisting of lobulated&#44; immature white fat cells with a prominent capillary pattern and&#44; frequently&#44; a focal myxoid matrix&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> The tumor can be localized or diffuse&#44; occurs predominantly in infancy and early childhood&#44; and affects patients aged 5 years or younger in 84&#37; of cases&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> Nevertheless&#44; rare cases have been reported in adolescents and adults&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3&#44;4</span></a> Most lipoblastomas are subcutaneous lesions affecting the arms and legs&#44; and they are more common in male patients&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We report the case of a distinctive mesenchymal neoplasm of the lip showing adipocytic differentiation in an adult woman&#46; We consider that this tumor is akin to infantile lipoblastoma&#46; As far as we are aware&#44; only 1 such lesion has been previously reported&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">A 36-year-old woman presented with a history of a small asymptomatic&#44; pigmented&#44; raised nodule on the vermilion border of the lower lip that had been present for about 9 months&#46; The patient had not undergone lip piercing&#44; filler injection for lip augmentation&#44; or any other interventions&#46; Her past medical history was not significant for systemic disease&#46; Physical examination revealed a soft&#44; brown-colored&#44; sessile nodule measuring 0&#46;8<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>0&#46;4<span class="elsevierStyleHsp" style=""></span>cm on the right half of the lower lip&#46; The clinical diagnosis was melanocytic nevus&#46; The lesion was completely removed&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The microscopic study showed a poorly demarcated lesion&#44; with epidermal acanthosis&#44; irregular papillomatosis&#44; and hyperpigmentation of the basal layer&#46; Scattered aggregates of immature fat cells replaced much of the submucosa &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#44; with a preferential perivascular location&#46; These cells showed variation in size and were multivacuolated lipoblasts&#44; which indented the nuclei and were interspersed with univacuolated lipoblasts that displaced the nuclei and looked like signet-ring fat cells&#46; Mature adipocytes were scant &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Hibernoma-like cells were not seen&#46; All the nuclei were small and monomorphic without atypia&#46; Mitotic figures were absent&#46; No giant cells&#44; lymphocytes&#44; mucin deposits&#44; or plexiform vascularization were observed&#46; Dermal aggregates were surrounded by numerous small vessels&#44; and were incompletely separated by the thick collagenous bundles of dermis&#46; In the depth of the lesion&#44; lipoblast aggregates were seen to form part of the adventitia of small veins or to infiltrate between the fascicles of the orbicularis muscle &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; No birefringence was observed in the adipocytic cells&#46; Alcian blue &#40;pH 2&#46;5&#41; did not show any acid mucin in the fat cell groups or in the dermal connective tissue&#46; The cells stained positively for vimentin and retinoblastoma antibody and negatively for AE1&#47;AE3 cytokeratin&#44; CD34&#44; CD31&#44; CD68&#44; and estrogen receptor&#46; Immature adipocytes showed moderate amounts of cytoplasmic mitochondria around fat vacuoles that were visible with the antimitochondrial antibody&#46; The amount of mitochondria was not comparable to that observed in the brown adipose tissue cells&#46; The neoplasm involved the surgical margins&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">There has been no local recurrence or metastasis in the 9 months since surgery&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The tumor in the case reported here shared histological features with lipoblastoma&#44; namely prominent lobulation&#44; immature fat cells consisting of multivacuolated and univacuolated lipoblasts admixed with mature fat cells&#44; conspicuous capillaries&#44; variably developed collagenous septae&#44; and diffuse borders&#46; The clinical manifestations suggested a diagnosis of melanocytic nevus due to the concomitant pigmented epidermal lesion&#46; We interpret the epidermal lesion as a reactive hyperplasia that may accompany lesions of this kind&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Lipoblastoma occurs primarily in infancy and early childhood&#44; but it can be observed in adolescents and young adults&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> Lae et al&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> described 2 cases in women aged 23 and 38 years&#44; and Silverman et al&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> reported a recurring lipoblastoma in a 48-year-old man&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">To our knowledge&#44; the present case is the second report of a lipoblastoma-like tumor of the lip&#46; Jeong et al&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> reported a similar intradermal lesion involving the lower lip of a 61-year-old woman&#46; The dermal tumor was erythematous&#44; slightly elevated&#44; and measured 2<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>1<span class="elsevierStyleHsp" style=""></span>cm&#46; The clinical differential diagnosis included Fordyce spot&#44; nevus lipomatosus superficialis&#44; and foreign body granuloma&#46; The excised specimen showed abundant dermal lobules composed of lipoblasts and mature cells&#46; The epidermis above the dermal tumor showed acanthosis and irregular papillomatosis&#44; which is a change similar to that observed in the case we are reporting&#46; Neither local recurrence nor metastasis was observed 1 year after surgery&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Lipoblastoma is a benign tumor&#44; but it can return in 9&#37; of cases&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> Recurrence may occur in the form of a mature lipomatous tumor&#46; The differential diagnosis includes other dermal tumors with lipoblasts such as atypical lipomatous tumor&#47;well-differentiated liposarcoma&#44; spindle cell&#47;pleomorphic lipoma&#44; and myxoid liposarcoma&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">The nature of lipoblastoma remains to be explained&#46; The structure of the lesion is reminiscent of the development of white adipose tissue&#46; White embryonal&#47;fetal fat is characterized by a very close association between adipocyte development and angiogenesis&#46; Both small univacuolated and multivacuolated adipocytes form lobules with abundant delicate branching capillaries&#46; It has been proposed that the white adipocyte precursor is derived from undifferentiated mesenchymal cells that reside in the mural cell compartment of the adipose vasculature&#46;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">8&#8211;10</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">The embryonal&#47;fetal structure of the lipoblastoma and its occurrence primarily in the very young suggests a hamartomatous lesion&#46;</p></span>"
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Article information
ISSN: 15782190
Original language: English
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