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Several studies have reported that the RCTs published in the dermatology literature tend to fall below acceptable standards&#46;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">1&#8211;4</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The Consolidated Standards of Reporting Trials &#40;CONSORT&#41; statement was first published in 1996 to improve the quality of reporting of clinical trials worldwide&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">5</span></a> The CONSORT statement includes a checklist designed to improve the reporting of RCTs&#44; which also&#44; indirectly&#44; throws light on the study&#39;s quality and scientific rigor&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">An improvement in the scientific quality and reporting of RCTs might have been expected following the implementation of CONSORT and the publication of the Medical Research Council Guidelines for Good Clinical Practice in Clinical Trials &#40;available from&#58; <a href="http://www.fda.gov/downloads/Drugs/Guidances/ucm073122.pdf">http&#58;&#47;&#47;www&#46;fda&#46;gov&#47;downloads&#47;Drugs&#47;Guidances&#47;ucm073122&#46;pdf</a> and <a href="http://www.mrc.ac.uk/documents/pdf/good-clinical-practice-in-clinical-trials/">http&#58;&#47;&#47;www&#46;mrc&#46;ac&#46;uk&#47;documents&#47;pdf&#47;good-clinical-practice-in-clinical-trials&#47;</a>&#41;&#46; However&#44; the evidence reveals the continued presence after 1997 of serious flaws in the design and reporting of clinical trials&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">6</span></a> The problem has also been observed in trials in the Spanish-language dermatology literature published after 1997&#46; A study carried out in Spain found that only 6 &#40;25&#37;&#41; of the 24 clinical trials found in the dermatology journal with the highest impact in that country&#8212;<span class="elsevierStyleSmallCaps">Actas Dermo-Sifiliogr&#225;ficas&#8212;</span>were classified as being of high quality&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">3</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">In this context&#44; the aim of the present study was to assess the methodological quality of the experimental clinical research in dermatology published in Spanish to facilitate an analysis of the strengths of these studies and the challenges that must be overcome&#46; We analyzed the RCTs identified by a recent study that handsearched Spanish-language dermatology journals&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">7</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">The present study complements that work by analyzing the methodological quality of the RCTs published between 1997 and 2012 using the appropriate Cochrane Collaboration tools and a review of the reporting of conflicts of interest and funding sources&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Objective</span><p id="par0035" class="elsevierStylePara elsevierViewall">To assess the methodological quality of the RCTs published in Spanish-language dermatology journals between 1997 and 2012&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Materials and Methods</span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Journal Identification&#58; Manual and Electronic Search</span><p id="par0040" class="elsevierStylePara elsevierViewall">The methodology used to identify the RCTs published in Spanish-language dermatology journals has already been described in an earlier article&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">7</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">In a preliminary phase&#44; all eligible journals were identified in the framework of a project led by the Iberoamerican Cochrane Centre &#40;IbCC&#41; in Barcelona&#44; Spain&#46; Using the IbCC protocol&#44; journals were located through the following search engines and databases&#58; MEDLINE &#40;through PubMED&#41;&#44; EMBASE&#44; LILACS &#40;Latin American Index of Scientific and Technical Literature&#41;&#44; SciELO&#44; Peri&#243;dica&#44; Latindex&#44; &#205;ndice M&#233;dico Espa&#241;ol&#44; Cat&#225;logo Nacional de Publicaciones Peri&#243;dicas en Ciencias de la Salud Espa&#241;olas &#40;C-17&#41;&#44; as well as in other catalogues of health sciences publications in Spain&#46; This initial search strategy was then complemented by a search of the Spanish health sciences indexes &#40;IBECS and IMBIOMED&#41;&#44; by free-text Internet searches using Google&#44; by contacting the Dermatology societies in each of the countries studied&#44; and through direct contact with dermatologists&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Each journal identified was then handsearched to identify all the RCTs published&#46; This retrospective review was carried out in accordance with the Cochrane Collaboration&#39;s manual for handsearching archives and identifying clinical trials &#40;available from <a href="http://www.cochrane.es/~cochrane/?q=es/node/140">http&#58;&#47;&#47;www&#46;cochrane&#46;es&#47;&#8764;cochrane&#47;&#63;q&#61;es&#47;node&#47;140</a>&#41;&#46; Each journal was searched from 2012 back to the first issue published &#40;provided full texts were still available&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">7</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">In addition to handsearching for RCTs&#44; we also conducted an electronic search of MEDLINE &#40;using PubMed&#41;&#44;EMBASE&#44; LILACS and IBECS&#44; as well as the search engines of the Biblioteca Virtual en Salud hosted by the Latin American and Caribbean Center on Health Sciences Information &#40;Bireme&#41;&#44; the Pan American Health Organization&#44; and the World Health Organization&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Data Extraction</span><p id="par0060" class="elsevierStylePara elsevierViewall">A database was created to store each of the RCTs retrieved&#44; to facilitate the handsearch of each journal&#44; and to ensure that data was gathered and processed in an organized and systematic manner&#46; We also identified journals specifying CONSORT reporting in their instructions to authors and journals indexed on MEDLINE or EMBASE&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Analysis of Quality and Risk of Bias</span><p id="par0065" class="elsevierStylePara elsevierViewall">Only RCTs published between 1997 &#40;the first year the CONSORT statement was implemented&#41; and 2012 were included in the review of scientific rigor and methodological quality&#46; The appraisal was performed twice&#44; and any resulting discrepancies were resolved by a third assessor&#46; The review was carried out using the Cochrane Collaboration tool for assessing risk of bias &#40;high&#47;medium&#47;low&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">8</span></a> This tool assesses the methodological aspects of clinical trials&#44; including sequence generation&#44; concealment of the sequence of patient allocation to the different arms of the study&#44; blinding of participants and outcome assessors&#44; incomplete data&#44; and patient follow-up&#46; The reviewer assesses each one of these domains and assigns one of the following answers&#58; &#8220;yes&#8221;&#44; &#8220;no&#8221;&#44; or &#8220;unclear&#47;not reported&#8221;&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Studies were categorized as having a &#8220;high risk of bias&#8221; if they had 1 flaw that affected the generation of the allocation sequence or had more than 1 flaw affecting any of the other methodological aspects analyzed&#46; If the necessary information was unavailable&#44; the study was categorized as &#8220;unclear risk&#47;not reported&#8221;&#46; The results of the assessment and scoring of these methodological aspects were recorded using version 5&#46;2 of the application Review Manager &#40;Copenhagen&#44; the Nordic Cochrane Centre&#44; The Cochrane Collaboration&#44; 2012&#41;&#46; Information on sources of funding and the reporting of potential conflicts of interest on the part of authors were also logged&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Statistical Analysis</span><p id="par0075" class="elsevierStylePara elsevierViewall">Descriptive statistics of the resulting information were compiled&#44; using univariate analysis to determine the frequencies of the variables&#46; Appropriate summary measures were calculated for the continuous variables&#46; Absolute and relative frequencies and their percentages were determined for qualitative variables&#46; When appropriate&#44; the confidence interval was calculated for proportions&#46; The data were recorded on Review Manager and also in an Excel spreadsheet &#40;Microsoft Office 2010&#41;&#46; The software package SPSS &#40;version 19&#44; IBM&#41; was used to analyze the data&#46;</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Results</span><p id="par0080" class="elsevierStylePara elsevierViewall">Of the 28 journals that fulfilled the criteria for eligibility&#44; 21 were eventually included in the study&#58; 5 from Spain and 16 from Latin American countries&#46; Of these 21 journals only <span class="elsevierStyleSmallCaps">Actas Dermo-Sifiliogr&#225;ficas</span> is currently indexed on both MEDLINE and EMBASE&#46; Four others are indexed on EMBASE&#58; <span class="elsevierStyleItalic">Dermatolog&#237;a Revista Mexicana</span>&#44; <span class="elsevierStyleItalic">Argentina de Dermatolog&#237;a&#44; Medicina Cut&#225;nea Ibero Latinoamericana</span> and <span class="elsevierStyleItalic">Piel&#46;</span><a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">7</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">The total number of journals included and excluded&#44; and the reasons for the choices made have been described in an earlier article &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">7</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Identification of Clinical Trials</span><p id="par0090" class="elsevierStylePara elsevierViewall">Seventy RCTs published between 1997 and 2012 were identified in the 21 journals studied&#58; 73&#37; &#40;51&#41; in the 16 Latin American journals and 27&#37; &#40;19&#41; in the 5 Spanish journals &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 1</a>&#41; &#40;<a class="elsevierStyleCrossRef" href="#sec0085">Appendix 1</a>&#41;&#46; The Latin American journals that published the largest number of RCTs were <span class="elsevierStyleItalic">Dermatolog&#237;a Revista Mexicana</span> &#40;16&#41;&#44; <span class="elsevierStyleItalic">Dermatolog&#237;a Peruana</span> &#40;9&#41;&#44; and <span class="elsevierStyleItalic">Revista Chilena de Dermatolog&#237;a</span> &#40;5&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 1</a>&#41;&#46; The Spanish journals that published the most RCTs were <span class="elsevierStyleSmallCaps">Actas Dermo-Sifiliogr&#225;ficas</span> and <span class="elsevierStyleItalic">Piel</span>&#44; with 8 each &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0095" class="elsevierStylePara elsevierViewall">Most of the trials reviewed were classified as having a high risk of bias because the authors failed to report the information needed to assess the quality and methodological rigor of the trial &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 2</a>&#41;&#46; A small percentage of trials had a low risk of bias in the domains assessed &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 2</a>&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0100" class="elsevierStylePara elsevierViewall">The authors of 15 RCTs reported sources of funding and only 2 did so in the required manner &#40;Ramirez-Bosca et al&#46; and Pinto et al&#46;&#41; &#40;<a class="elsevierStyleCrossRef" href="#sec0085">Appendix 1</a>&#41;&#46; The authors of 5 studies reported conflicts of interest&#44; but only 1 of these reports conformed to accepted standards &#40;Ramirez-Bosca et al&#46;&#41; &#40;<a class="elsevierStyleCrossRef" href="#sec0085">Appendix 1</a>&#41;&#46; Of all the journals assessed&#44; only <span class="elsevierStyleSmallCaps">Actas Dermo-Sifiliogr&#225;ficas&#44;</span>since <span class="elsevierStyleSmallCaps">2008&#44;</span> requires authors to report trials in accordance with the CONSORT guidelines&#59; however&#44; none of the authors reported in the body of the article whether or not the CONSORT checklist had been used to guide the reporting of the study&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a> is a summary of the risk of bias for the RCTs identified&#46;</p></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Discussion</span><p id="par0110" class="elsevierStylePara elsevierViewall">The objective of this study was to assess the methodological quality of the RCTs published in Spanish-language dermatology journals between 1997 and 2012&#46; Our findings show that the risk of bias was high in the clinical trials published in the Spanish-language dermatology literature in that period&#44; primarily because authors failed to report on important methodological aspects of their work&#46; Although this shortcoming had already been described in earlier studies focusing on specific dermatology journals in Spanish&#44;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">9</span></a> this is the first comprehensive analysis that covers all the dermatology journals publishing RCTs in Spain and Latin America&#46; Our findings are similar to those of authors who studied RCTs in the English-language dermatology literature or RCTs on diseases such as perioral dermatitis and atopic dermatitis&#46;<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">4&#44;10&#44;11</span></a></p><p id="par0115" class="elsevierStylePara elsevierViewall">The presence of such flaws in RCTs is of particular concern because this type of study is considered to be a gold standard for the assessment of the efficacy and safety of an intervention&#46; Consequently&#44; the implication is that dermatological practice today &#40;at least that predicated on evidence from the studies assessed&#41; may be based on information gathered in a non-systematic manner or on clinical experiments lacking control groups&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">12</span></a> We also detected a mismatch between the outcomes typically assessed and those that might interest patients&#46; For example&#44; many dermatology studies now incorporate variables relating to quality-of life because of the considerable interest of patients in this outcome in relation to dermatological treatments&#46;<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">13&#8211;15</span></a> However&#44; it is striking that quality-of-life was assessed in only 1 of the 70 RCTs identified&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">The methodological aspects least often reported were random sequence generation and allocation concealment&#59; authors also failed to report on sources of funding and possible conflicts of interest&#46; Our findings&#44; which are similar to those observed by other authors in journals that endorse CONSORT reporting as well as in those that do not&#44;<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">6&#44;16&#44;17</span></a> highlight shortcomings in the scientific rigor with which the RCTs were designed and reported&#46; In the future&#44; experimental clinical research published in Spain and Latin America in the field of dermatology needs to be considerably improved both in the design and the reporting of results &#40;endorsement and application of the CONSORT guidelines&#41;&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">The starting point for an unbiased study is the use of a mechanism that ensures that all the patients have the same probability of belonging to one group or the other&#44; and that adequate concealment of the allocation sequence prevents selective recruitment of patients according to prognostic factors &#40;guidelines available from <a href="http://handbook.cochrane.org/">http&#58;&#47;&#47;handbook&#46;cochrane&#46;org&#47;</a>&#41;&#46; In fact&#44; it has been shown that inadequate random sequence generation in an RCT can result in an overestimation of the effect of the treatment of up to 12&#37;&#44;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">18</span></a> while inadequate allocation concealment may increase the effect up to 18&#37;&#46; Furthermore&#44; the fact that a clinical experiment is classified as randomized does not&#44; in and of itself&#44; guarantee that the study fulfils the methodological standards associated with this type of study&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">19</span></a></p><p id="par0130" class="elsevierStylePara elsevierViewall">The only journal included in this study that requires authors to comply with the CONSORT statement when reporting clinical trials is <span class="elsevierStyleSmallCaps">Actas Dermo-Sifiliogr&#225;ficas</span>&#46; This endorsement may explain the higher methodological quality of the RCTs published recently by that journal&#46; However&#44; it has been observed that&#44; despite improvements in reporting of RCTs when this tool is used&#44; the completeness of reporting of trials continues to be suboptimal in terms of ensuring a better quality of study&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">6</span></a></p><p id="par0135" class="elsevierStylePara elsevierViewall">Of note is the fact that almost none of the trials identified provided any information on sources of funding or conflicts of interest&#46; Complete reporting of both of these aspects is essential since the results of the trial may be affected by the personal interests of the researcher or the funder of the study &#40;very often a pharmaceutical company&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0220"><span class="elsevierStyleSup">20&#8211;22</span></a> Transparency is important because it is common in the dermatology literature to find selective reporting of endpoints&#44; a practice which in most cases leads to the overestimation of positive outcomes&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">23</span></a> This practice may be associated with the presence of conflicts of interest&#46; Therefore&#44; in the future careful assessment of these characteristics will be essential in the studies published in Spanish-language dermatology journals&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">24</span></a></p><p id="par0140" class="elsevierStylePara elsevierViewall">One of the principal strengths of the present study was that 21 dermatology journals published in Spanish were handsearched to identify RCTs&#46; The clinical trials identified will shortly be included in the Cochrane Central Register of Controlled Trials &#40;CENTRAL&#41;&#44; making them available for future systematic reviews and other summary documents&#46; As reported by the earlier article&#44; which identified the RCTs<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">7</span></a> analyzed in the present study&#44; finding 70 RCTs and retrieving the full texts of those articles would have been impossible through an electronic search because only 1 journal is indexed on MEDLINE &#40;Actas Dermo-Sifiliogr&#225;ficas&#41; and only 4 are indexed on EMBASE<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">7</span></a> &#40;<span class="elsevierStyleItalic">Dermatolog&#237;a Revista Mexicana&#44; Revista Argentina de Dermatolog&#237;a&#44; Medicina Cut&#225;nea Ibero Latinoamericana</span> and <span class="elsevierStyleItalic">Piel</span>&#41;&#46; Another strength of the present study was the duplicate analysis of the quality of the RCTs and the use of internationally-recognized and validated Cochrane tools&#46; &#40;Available from&#58; <a href="http://handbook.cochrane.org/chapter_8/8_assessing_risk_of_bias_in_included_studies.htm">http&#58;&#47;&#47;handbook&#46;cochrane&#46;org&#47;chapter&#95;8&#47;8&#95;assessing&#95;risk&#95;of&#95;bias&#95;in&#95;included&#95;studies&#46;htm</a>&#41;&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">The main limitation of this study was the impossibility of assessing all the volumes and issues of 3 journals&#58; 2 published in Ecuador and 1 published in the Dominican Republic&#46; However&#44; it is unlikely that our results would have differed significantly with a complete analysis of these 3 journals since no RCTs were found in the issues we were able to review&#46; Furthermore&#44; none of those journals have endorsed the CONSORT statement or require its use&#46; Another limitation was the variability of the endpoints and the way these were measured in the RCTs identified&#46; This variability led to a high level of heterogeneity among the studies&#44; making it difficult to quantitatively summarize the results in a meta-analysis</p><p id="par0150" class="elsevierStylePara elsevierViewall">In conclusion&#44; the risk of bias of the clinical trials published in Spanish-language dermatology journals between 1997 and 2012 was high&#44; mainly because the study reports provided insufficient information on which to base any assessment of the quality and methodological rigor of the studies&#46; Moreover&#44; in many cases the authors failed to report on sources of funding and possible conflicts of interest&#46; Complete reporting of all methodological aspects of trials is recommended&#44; as this would allow readers to detect possible sources of bias and design flaws&#46; A complete description of the study is important because it facilitates proper analysis of the evidence and because it ensures that a trial is not classified as having a high risk of bias solely because of omissions in the information provided&#46; Complete reporting will benefit patients&#8212;the foundation of evidence-based dermatological practice&#8212;and will contribute to more effective decision-taking in this field of practice&#46; Finally&#44; and as a future strategy&#44; we plan to contact the publishers of the dermatology journals analyzed with a view to standardizing prospective tools for the identification of the RCTs published in their journals&#46; The implementation of such a system will facilitate continual updating of this work&#44; thereby obviating the need to repeat the manual search in the future&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Ethical Disclosures</span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Protection of human and animal subjects</span><p id="par0155" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals during the course of this study&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Data confidentiality</span><p id="par0160" class="elsevierStylePara elsevierViewall">The authors declare that no private patient data are disclosed in this article&#46;</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Right to privacy and informed consent</span><p id="par0165" class="elsevierStylePara elsevierViewall">The authors declare that no private patient data are disclosed in this article&#46;</p></span></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0145">Funding</span><p id="par0170" class="elsevierStylePara elsevierViewall">Grupo de Investigaci&#243;n Dermatol&#243;gica &#40;GRID&#41;&#44; Facultad de Medicina&#44; Universidad de Antioquia&#44; Medell&#237;n&#44; Colombia&#46;</p></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0150">Conflicts of Interest</span><p id="par0175" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The value of randomized clinical trials &#40;RCTs&#41; undertaken to identify an association between an intervention and an outcome is determined by their quality and scientific rigor&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objective</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To assess the methodological quality of RCTs published in Spanish-language dermatology journals&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">By way of a systematic manual search&#44; we identified all the RCTs in journals published in Spain and Latin America between 1997 &#40;the year in which the CONSORT statement was published&#41; and 2012&#46; Risk of bias was evaluated for each RCT by assessing the following domains&#58; randomization sequence generation&#44; allocation concealment&#44; blinding of patients and those assessing outcomes&#44; missing data&#44; and patient follow-up&#46; Source of funding and conflict of interest statements&#44; if any&#44; were recorded for each study&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The search identified 70 RCTs published in 21 journals&#46; Most of the RCTs had a high risk of bias&#44; primarily because of gaps in the reporting of important methodological aspects&#46; The source of funding was reported in only 15 studies&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Discussion and conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">In spite of the considerable number of Spanish and Latin American journals&#44; few RCTs have been published in the 15 years analyzed&#46; Most of the RCTs published had serious defects in that the authors omitted methodological information essential to any evaluation of the quality of the trial and failed to report sources of funding or possible conflicts of interest for the authors involved&#46; Authors of experimental clinical research in dermatology published in Spain and Latin America need to substantially improve both the design of their trials and the reporting of results&#46;</p></span>"
        "secciones" => array:5 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Introduction"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Objective"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Methods"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Results"
          ]
          4 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Discussion and conclusions"
          ]
        ]
      ]
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Introducci&#243;n</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">La relevancia del ensayo controlado con asignaci&#243;n aleatoria &#40;ECA&#41; para determinar si existe una asociaci&#243;n entre una intervenci&#243;n y un desenlace est&#225; determinada por su calidad y rigor cient&#237;fico&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Objetivo</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Evaluar la calidad metodol&#243;gica de los ECA publicados en revistas dermatol&#243;gicas en espa&#241;ol&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">M&#233;todos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Se realiz&#243; una b&#250;squeda manual y sistem&#225;tica de los ECA publicados en las revistas de Dermatolog&#237;a espa&#241;olas y latinoamericanas entre 1997 &#40;publicaci&#243;n de los criterios CONSORT&#41; y 2012&#46; Se determin&#243; el riesgo de sesgo de cada ECA&#44; evaluando los siguientes dominios&#58; generaci&#243;n de la secuencia aleatoria&#44; ocultamiento de la asignaci&#243;n&#44; cegamiento de los pacientes&#47;evaluadores de desenlaces&#44; datos faltantes y seguimiento de pacientes&#46; Se identificaron la fuente de financiaci&#243;n de los estudios y el reporte de conflictos de inter&#233;s&#46;</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Se identificaron 70 ECA publicadas en 21 revistas&#46; La mayor&#237;a de los ECA tuvo un alto riesgo de sesgo&#44; principalmente por falta de reporte de los aspectos metodol&#243;gicos importantes&#46; Solo 15 estudios declararon fuentes de financiaci&#243;n&#46;</p></span> <span id="abst0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Discusi&#243;n y conclusiones</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">A pesar del n&#250;mero considerable de revistas existentes en Espa&#241;a y Latinoam&#233;rica&#44; en los 15 a&#241;os estudiados se han publicado pocos ECA&#46; La mayor&#237;a de los estudios present&#243; problemas de calidad importantes&#44; al carecer de informaci&#243;n metodol&#243;gica que permitiera evaluar su calidad y a las falencias en el reporte de las fuentes de financiaci&#243;n y de los conflictos de inter&#233;s de los autores&#46; La investigaci&#243;n cl&#237;nica experimental dermatol&#243;gica que se publica en Ibero-Latinoam&#233;rica debe mejorar ostensiblemente tanto en su dise&#241;o como en su reporte de resultados&#46;</p></span>"
        "secciones" => array:5 [
          0 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Introducci&#243;n"
          ]
          1 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Objetivo"
          ]
          2 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "M&#233;todos"
          ]
          3 => array:2 [
            "identificador" => "abst0045"
            "titulo" => "Resultados"
          ]
          4 => array:2 [
            "identificador" => "abst0050"
            "titulo" => "Discusi&#243;n y conclusiones"
          ]
        ]
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Sanclemente G&#46; An&#225;lisis de la calidad de los ensayos cl&#237;nicos publicados en revistas dermatol&#243;gicas publicadas en espa&#241;ol entre 1997 y 2012&#46; Actas Dermosifiliogr&#46; 2016&#59;107&#58;44&#8211;54&#46;</p>"
      ]
    ]
    "apendice" => array:1 [
      0 => array:1 [
        "seccion" => array:1 [
          0 => array:3 [
            "apendice" => "<p id="par0190" class="elsevierStylePara elsevierViewall"><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></p>"
            "etiqueta" => "Appendix 1"
            "identificador" => "sec0085"
          ]
        ]
      ]
    ]
    "multimedia" => array:5 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 4333
            "Ancho" => 3338
            "Tamanyo" => 649443
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Flow chart showing the process used to select dermatology journals according to inclusion and exclusion criteria&#46; Source&#58; Sanclemente G&#44; Pardo H&#44; S&#225;nchez S&#44; Bonfill X&#46; Identificaci&#243;n de ensayos cl&#237;nicos en revistas dermatol&#243;gicas publicadas en espa&#241;ol&#46; Actas Dermosifiliogr&#46; 2015&#59;106&#58;415-422&#41;&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1503
            "Ancho" => 2837
            "Tamanyo" => 216574
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        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Risk of bias of the RCTs analyzed &#40;graphic designed using Review Manager&#44; version 5&#46;2&#44; Copenhagen&#44; The Nordic Cochrane Centre&#44; The Cochrane Collaboration&#44; 2012&#41;&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Journal Name&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Periods Not Assessed Because No Copies &#40;Print or Electronic&#41; Available&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Number of RCTs Identified&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Dermatolog&#237;a Revista Mexicana</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Dermatolog&#237;a Peruana</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleSmallCaps">Actas Dermo-Sifiliogr&#225;ficas</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Piel</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Revista Chilena de Dermatolog&#237;a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Dermatolog&#237;a Cosm&#233;tica&#44; M&#233;dica Y Quir&#250;rgica</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Revista del Centro Dermatol&#243;gico Pascua</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Revista Asociaci&#243;n Colombiana de Dermatolog&#237;a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Medicina Cut&#225;nea Ibero-Latino-Americana</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Folia Dermatol&#243;gica Peruana</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Dermatolog&#237;a Argentina</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Folia Dermatol&#243;gica Cubana</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Dermatolog&#237;a Venezolana</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Revista Argentina de Dermatolog&#237;a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Archivos Argentinos de Dermatolog&#237;a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Actas de Dermatolog&#237;a y Dermatopatolog&#237;a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Revista Dominicana de Dermatolog&#237;a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1997-2009&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Revista Sociedad Ecuatoriana de Dermatolog&#237;a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1997-2002&#44; 2005&#44; 2008&#44; 2009&#44; 2011&#44; 2012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Gaceta Dermatol&#243;gica Ecuatoriana</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1999-2012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Actualidad Dermatol&#243;gica</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Revista Fontilles</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1997-2002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">70&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Randomized Controlled Trials &#40;RCTs&#41; Identified in Spanish and Latin American Dermatology Journals&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Methodological Aspect&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">No&#46; &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">95&#37; CI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleItalic">Allocation concealment</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Unclear&#47;Not reported&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">48 &#40;68&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">57&#46;73&#37;-79&#46;47&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">14 &#40;20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&#46;63&#37;-29&#46;37&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8 &#40;11&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#46;95&#37;-18&#46;85&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="char" valign="top"><span class="elsevierStyleItalic">Sequence generation</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Unclear&#47;Not reported&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">62 &#40;88&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">81&#46;15&#37;-96&#46;05&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6 &#40;8&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#46;03&#37;-15&#46;17&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;2&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;1&#46;06&#37;-6&#46;66&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="char" valign="top"><span class="elsevierStyleItalic">Blinding of participants&#47;personnel</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Unclear&#47;Not reported&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">44 &#40;62&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">51&#46;48&#37;-74&#46;12&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11 &#40;15&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&#46;18&#37;-24&#46;22&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15 &#40;21&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&#46;88&#37;-31&#46;12&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="char" valign="top"><span class="elsevierStyleItalic">Blinding of outcome assessors</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Unclear&#47;Not reported&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">44 &#40;62&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">51&#46;48&#37;-74&#46;12&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11 &#40;15&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&#46;18&#37;-24&#46;22&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15 &#40;21&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&#46;88&#37;-31&#46;12&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="char" valign="top"><span class="elsevierStyleItalic">Incomplete outcome data</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Unclear&#47;Not reported&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">42 &#40;60&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">48&#46;52&#37;-71&#46;48&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13 &#40;18&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&#46;4&#37;-27&#46;6&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15 &#40;21&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&#46;88&#37;-31&#46;12&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="char" valign="top"><span class="elsevierStyleItalic">Selective outcome reporting</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Unclear&#47;Not reported&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12 &#40;17&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&#46;36&#37;-26&#46;04&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">44 &#40;62&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">51&#46;48&#37;-74&#46;12&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">14 &#40;20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&#46;63&#37;-29&#46;37&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="char" valign="top"><span class="elsevierStyleItalic">Other sources of bias</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Unclear&#47;Not reported&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">35 &#40;50&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">38&#46;29&#37;-61&#46;71&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5 &#40;7&#44; 15&#44; 8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&#46;26&#37;-24&#46;34&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">30 &#40;42&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">31&#46;31&#37;-54&#46;49&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="char" valign="top"><span class="elsevierStyleItalic">Funding sources</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Not reported&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">55 &#40;78&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">68&#46;99&#37;-88&#46;21&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Reported&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15 &#40;21&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&#46;79&#37;-31&#46;01&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="char" valign="top"><span class="elsevierStyleItalic">Conflicts of Interest</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Not reported&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">65 &#40;92&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">86&#46;74&#37;-98&#46;86&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Reported&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5 &#40;7&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;14&#37;-13&#46;26&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">1&#46; Alac&#225;n PL&#44; Lemus CO&#44; Lima AAS&#44; Moredo RE&#46; Eficacia de podofilina&#44; &#225;cido tricloroac&#233;tico y criocirug&#237;a en el tratamiento de las verrugas genitales externas&#46; Folia Dermatol Cub&#46; 2012&#59;6&#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">2&#46; Alfaro-Orozco LP&#44; Alcal&#225;-P&#233;rez D&#44; Navarrete-Franco G&#44; Gonz&#225;lez- Gonz&#225;lez M&#44; Peralta-Pedrero ML&#46; Efectividad de la soluci&#243;n de Jessner m&#225;s &#225;cido tricloroac&#233;tico al 35&#37; vs 5-fluorouracilo al 5&#37; en queratosis act&#237;nicas faciales m&#250;ltiples&#46; Dermatol Rev Mex&#46; 2012&#59;56&#58;38-46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">3&#46; Alfonso-Trujillo I&#44; Acosta D&#44; &#193;lvarez M&#44; Pernas A&#44; Toledo MC&#44; Rodr&#237;guez MA&#46; Condiloma acuminado&#58; eficacia terap&#233;utica comparativa entre el &#225;cido tricloroac&#233;tico solo y el &#225;cido tricloroac&#233;tico asociado al levamisol&#46; Dermatol Per&#250;&#46; 2009&#59;19&#58; 114-121&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">4&#46; Alfonso-Trujillo I&#44; Acosta Medina D&#44; &#193;lvarez Labrada M&#44; Rub&#233;n Quesada M&#44; Rodr&#237;guez Garc&#237;a MA&#46; Condiloma acuminado&#58; eficacia terap&#233;utica comparativa entre la podofilina sola y la podofilina combinada con levamisol&#46; Piel&#46; 2009&#59;24&#58;354-359&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">5&#46; Alfonso-Trujillo I&#44; Acosta-Medina D&#44; &#193;lvarez-Labrada M&#44; Guti&#233;rrez AR&#44; Rodr&#237;guez-Garc&#237;a MA&#44; Collazo-Caballero S&#46;&#191;Radiocirug&#237;a o criocirug&#237;a en condiloma acuminado de localizaci&#243;n anal&#63; Dermatol Peru&#46; 2008&#59;18&#58;98-105&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">6&#46; Alfonso-Trujillo I&#44; Rodr&#237;guez Garc&#237;a MA&#44; Rosa Guti&#233;rrez A&#44; Acosta Medina D&#44; Navarro Maestre M&#44; Collazo Caballero S&#46; &#191;&#193;cido tricloroac&#233;tico o criocirug&#237;a en el tratamiento del condiloma acuminado&#63; Piel&#46; 2009&#59;24&#40;4&#41;&#58;176-180&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">7&#46; Alfonso-Trujillo I&#44; Alvarez Labrada M&#44; Guti&#233;rrez Rojas AR&#44; Rodr&#237;guez Garc&#237;a MA&#44; Collazo Caballero S&#46; Condiloma acuminado&#58; eficacia terap&#233;utica comparativa entre la podofilina y la criocirug&#237;a&#46; Dermatol Per&#250;&#46; 2008&#59;18&#40;1&#41;&#58;27-34&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">8&#46; Alonzo Romero Parey&#243;n L&#44; Navarrete Franco G&#44; Hugo Alarc&#243;n H&#44; Izabal M&#46; Tratamiento del herpes z&#243;ster con ribavirina oral y t&#243;pica vs placebo&#46; Efecto sobre la incidencia de neuralgia postherp&#233;tica&#46; Estudio doble ciego&#46; Rev Cent Dermatol Pascua&#46; 2000&#59;9&#58;39-42&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">9&#46; Amrouni B&#44; Pereiro M Jr&#44; Iglesias A&#44; Labandeira J&#44; Toribio J&#46; Estudio comparativo en fase <span class="elsevierStyleSmallCaps">iii</span> del clotrimazol y flutrimazol en la vulvovaginitis candidi&#225;sica aguda&#46; Actas Dermosifiliogr&#46; 1999&#59;90&#40;S1&#41;72-73&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">10&#46; Calder&#243;n C&#44; Guti&#233;rrez RM&#46; Imiquimod al 5&#37; en el tratamiento del carcinoma basocelular&#46; Evaluaci&#243;n de la eficacia y tolerabilidad&#46; Dermatol Rev Mex&#46; 2002&#59;46&#58;114-120&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">11&#46; Carbajosa Mart&#237;nez J&#44; Arenas R&#46; Onicomicosis&#46; Evaluaci&#243;n de la utilidad del curetaje quir&#250;rgico en el tratamiento combinado &#40;oral y t&#243;pico&#41;&#46; Dermatolog&#237;a CMQ&#46; 2008&#59;6&#40;3&#41;&#58;157-162&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">12&#46; Castillo-Oliva A&#44; Alfonso-Trujillo I&#44; Montecer-Ramosa B&#44; Nodarse-Cun&#237;b H&#44; P&#233;rez-Alonso T&#44; Collazo-Caballero S&#44; et al&#46; Uso de crema de interfer&#243;n alfa leucocitario humano en condilomas acuminados&#46; Piel&#46; 2009&#59; 24&#40;7&#41;&#58;350-353&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">13&#46; Catacora-Cama J&#44; Cavero-Guardamino J&#44; Manrique-Silva D&#44; Delgado-Gonz&#225;lez V&#44; Aliaga-Ochoa E&#46; Estudio comparativo de la seguridad y eficacia del furoato de mometasona vs dipropionato de betametasona en psoriasis&#46; Folia Dermatol Per&#46; 2001&#59;12&#58;1-6&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">14&#46; Chouela E&#44; Fleischmajer R&#44; Pellerano G&#44; Poggio N&#44; Demarchi M&#44; Mozzone R&#44; et al&#46; Tetraciclinas en el tratamiento de la psoriasis&#46; Dermatol Argentina&#46; 2004&#59;4&#58;307-312&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">15&#46; Dom&#237;nguez Soto L&#44; Hojyo MT&#44; Eljure N&#44; Ranone VA&#44; Garibay Valencia M&#44; Fortu&#241;o Cordova V&#46; Estudio comparativo entre 5-fluorouracilo a 0&#44;5&#37; en liposomas y 5-fluorouracilo a 5&#37;&#44; crema en tratamiento de queratosis act&#237;nica&#46; Dermatolog&#237;a CMQ&#46; 2010&#59;8&#58;173-183&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">16&#46; Dominguez-Gomez J&#44; Daniel-Sim&#243;n R&#44; Abreu-Daniel A&#46; Eficacia del &#225;cido glicirric&#237;nico &#40;Herpigen-Glizygen&#41; y un inmunoestimulador &#40;Viusid&#41; en el tratamiento de verrugas genitales&#46; Folia Dermatol Cub&#46; 2008&#59;2&#40;3&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">17&#46; Dressend&#246;rfer LM&#44; Jervis C&#44; Palacios S&#46; Eficacia terap&#233;utica con el m&#233;todo de Goeckerman en pacientes con psoriasis en placas&#46; Trabajo realizado en el servicio de Dermatolog&#237;a del Hospital Carlos Andrade Mar&#237;n &#40;Ecuador&#41;&#44; agosto-noviembre de 2001&#46; Rev Argent Dermatol&#46; 2006&#59;87&#58;238-246&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">18&#46; Fern&#225;ndez G&#44; Enr&#237;guez J&#46; Onicocriptosis&#58; estudio comparativo del periodo posoperatorio de una matricectom&#237;a parcial lateral con el de una matricectom&#237;a parcial lateral con fenolizaci&#243;n&#46; Dermatol Rev Mex&#46; 2006&#59;50&#58;87-93&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">19&#46; Ferr&#225;ndiz C&#44; Bielsa I&#44; Ribera M&#44; Fuente MJ&#44; Carrascosa JM&#46; Terapia de refuerzo en pacientes con psoriasis tratada con calcipotriol&#46; Actas Dermosifiliogr&#46; 1998&#59;89&#58;626-630&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">20&#46; Fonseca Capdevila E&#46; Eficacia de eberconazol crema al 1&#37; frente a clotrimazol crema al 1&#37; en pacientes con micosis cut&#225;neas&#46; Piel&#46; 2004&#59;19&#58;480-484&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">21&#46; Fonseca Capdevila E&#44; L&#243;pez Bran E&#44; Fern&#225;ndez Vozmediano JM&#44; Torre Fraga C de la&#59;&#44; Querol Nasarre I&#44; Moreno Gim&#233;nez JC&#46; Prevenci&#243;n de secuelas cicatriciales de la extirpaci&#243;n de lesiones cut&#225;neas benignas&#58; estudio multic&#233;ntrico&#44; prospectivo&#44; abierto y controlado que compara un gel de silicona y l&#225;minas de silicona en 131 pacientes con nevos melanoc&#237;ticos&#46; Piel&#46; 2007&#59;22&#40;9&#41;&#58;421-426&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">22&#46; Fonseca E&#44; del Pozo J&#44; M&#225;rquez M&#44; Herrero E&#44; Fillat O&#44; Torres J&#44; rt al&#46; Evaluaci&#243;n de la eficacia y seguridad del sertaconazol en crema en aplicaci&#243;n &#250;nica diaria en el tratamiento de las dermatofitosis&#46; Piel&#46; 1997&#59;12 183-188&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">23&#46; Gajardo Julio G&#44; Valenzuela Gabriel R&#46; Eficacia de la tretino&#237;na t&#243;pica en fotoenvejecimiento cut&#225;neo&#58; estudio doble ciego randomizado&#46; Rev Chil Dermatol&#46; 2002&#59;18&#58;111-116&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">24&#46; Galarza Manyari C&#46; Eficacia y seguridad del tratamiento t&#243;pico con capsaicina 0&#44;075 por ciento vs capsaicina 0&#44;050 por ciento en el tratamiento de la neuralgia postherp&#233;tica&#46; Hospital Nacional Dos de Mayo&#46; Marzo 2003-febrero 2004&#46; Dermatol Peru&#46; 2005&#59;15&#58;108-112&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">25&#46; Gaxiola-&#193;lvarez E&#44; Jurado Santa-Cruz F&#44; Dom&#237;nguez-G&#243;mez MA&#44; Peralta-Pedrero ML&#46; Tratamiento de la alopecia areata en placas con capsaicina en ung&#252;ento al 0&#44;075&#37;&#46; Rev Cent Dermatol Pascua&#46; 2012&#59;21&#58;91-98&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">26&#46; Guerra-T&#224;pia A&#44; D&#237;az-Castella JM&#44; Bala&#241;&#225;-Vilanova M&#44; Borr&#224;s-M&#250;rcia C&#46; Estudio para valorar la repercusi&#243;n de una intervenci&#243;n informativa en la expectativa&#44; el cumplimiento y la satisfacci&#243;n de los pacientes con onicomicosis tratados con terbinafina&#46; Estudio TERESA&#46; Piel&#46; 2005&#59;20&#58;211-218&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">27&#46; Guerrero Robinson A&#44; Medina Raquel K&#44; Kahn Mariana Ch&#44; Guerrero Javiera M&#46; Utilidad y seguridad del 17-alfa-estradiol 0&#44; 025 por ciento versus minoxidil 2 por ciento en el tratamiento de la alopecia androg&#233;nica&#46; Rev Chil Dermatol&#46; 2009&#59;25&#40;1&#41;&#58;21-25&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">28&#46; Herr&#225;n P&#44; Ponce R&#44; Tirado A&#46; Eficacia y seguridad del 2-octil cianoacrilato versus sutura simple de heridas quir&#250;rgicas en piel con inflamaci&#243;n cr&#243;nica&#46; Dermatol Rev Mex&#46; 2011&#59;55&#58;185-187&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">29&#46; Hinostroza-da-Conceicao D&#44; Beirana-Palencia A&#46; Tratamiento del molusco contagioso con hidr&#243;xido de potasio al 15&#37; en soluci&#243;n acuosa&#46; Dermatol Peru&#46; 2004&#59;14&#58;185-191&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">30&#46; Honeyman J&#46; Isotretino&#237;na oral en dosis bajas en el tratamiento del acn&#233; moderado&#46; Dermatolog&#237;a Argentina&#46; 1998&#59;4&#58;338-344&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">31&#46; Jim&#233;nez RN&#44; Aguirre AC&#44; Ponce HS&#44; Velasco AF&#46; Mini injerto aut&#243;logo de piel e ingesti&#243;n de 8-metoxipsoraleno en pacientes con vitiligo vulgar estable&#46; Dermatol Rev Mex&#46; 2002&#59;46&#58;260-267&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">32&#46; Lapadula MM&#44; Stengel FM&#44; Maskin M&#44; Gonz&#225;lez P&#44; Kaczvinsky Jr J&#44; Soto R J&#44; Get al&#46; Estudio cl&#237;nico para evaluar el efecto de dos cremas humectantes con protector solar en la piel de pacientes que utilizan tretino&#237;na 0&#44;025&#37; para el tratamiento del fotoda&#241;o&#46; Med Cutan Ibero Lat&#46; 2008&#59;36&#40;5&#41;&#58;232-239&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">33&#46; Liz&#225;rraga Garc&#237;a C&#44; Rodr&#237;guez Acar M&#46; Impacto de la adherencia en la efectividad de candidina intralesional vs &#225;cido salic&#237;lico t&#243;pico al 27&#37; en el tratamiento de las verrugas vulgares&#46; Rev Cent Dermatol Pascua&#46; 2009&#59;18&#58;5-18&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">34&#46; L&#243;pez E&#44; &#193;lvarez M&#44; Agorio C&#44; Avenda&#241;o M&#44; Bonasse J&#44; Chavarr&#237;a A&#44; et al&#46; Tratamiento comparativo entre ivermectina v&#237;a oral y permetrina t&#243;pica en la escabiosis&#46; Rev Chil Dermatol&#46; 2003&#59;19&#58;27-32&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">35&#46; Loyo ME&#44; Zapata G&#44; Santana G&#46; Molusco contagioso&#58; evaluaci&#243;n de diversas modalidades terap&#233;uticas&#46; Dermatolog&#237;a Venezolana&#46; 2003&#59;41&#40;2&#41;&#58;25-28&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">36&#46; Lugo-Villeda L&#44; Leon-Dorantes G&#44; Blancas Gonz&#225;lez F&#46; Thuja occidentalis homeop&#225;tica vs- placebo en verrugas vulgares&#46; Dermatol Rev Mex&#46; 2001&#59;45&#58;14-18&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">37&#46; Llergo Valdez RJ&#44; Enr&#237;quez Merino J&#46; Eficacia y tolerabilidad del polidocanol al 1&#37; en el tratamiento con escleroterapia de v&#225;rices grado <span class="elsevierStyleSmallCaps">i</span> y <span class="elsevierStyleSmallCaps">ii</span>&#44; empleando compresi&#243;n en el tercio proximal afectado&#46; Rev Cent Dermatol Pascua&#46; 2008&#59;17&#58;79-83&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">38&#46; Magui&#241;a C&#44; Gotuzzo E&#44; &#193;lvarez H&#46; Nuevos esquemas terap&#233;uticos en el loxoscelismo Cut&#225;neo en Lima&#44; Per&#250;&#46; Folia Dermatol&#243;gica Peruana&#46; 1997&#59;2&#58;1-11&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">39&#46; Mart&#237;n Ezquerra G&#44; S&#225;nchez Rega&#241;a M&#44; Umbert Millet P&#46; Tratamiento de psoriasis en placas estable con un preparado que contiene furfuril sorbitol&#46; Med Cut&#225;n Ibero Lat&#46; 2006&#59;34&#58; 155-158&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">40&#46; Mart&#237;nez-Abundis E&#44; Gonz&#225;lez-Ortiz M&#44; Reynoso-von Drateln C&#44; Pascoe- Gonz&#225;lez S&#44; de la Rosa-Zamboni D&#46; Efecto de una mezcla de champ&#250; y anticonceptivos orales sobre el fol&#237;culo piloso en mujeres sanas&#46; Dermatol Rev Mex&#46; 2004&#59;48&#58;77-81&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">41&#46; Martorell-Calatayud A&#44; Requena C&#44; Nagore E&#44; Sanmart&#237;n O&#44; Serra-Guill&#233;n C&#44; Botella-Estrada R&#44; et al&#46; Ensayo cl&#237;nico&#58; la infiltraci&#243;n intralesional con metotrexato de forma neoadyuvante en la cirug&#237;a del queratoacantoma permite obtener mejores resultados est&#233;ticos y funcionales&#46; Actas Dermosifiliogr&#46; 2011&#59;102&#58;605-615&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">42&#46; M&#233;ndez-Velarde FA&#44; Salceda-P&#233;rez MA&#44; Borj&#243;n-Moya C&#44; Azpeitia- de la O CM&#44; V&#225;zquez-Coronado DP&#44; Ore-Colio L&#46; Efecto de una crema hidratante para prevenir las estr&#237;as del embarazo&#46; Dermatol Rev Mex&#46; 2010&#59;54&#58;273-278&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">43&#46; Morales-Toquero A&#44; Ocampo-Candiani J&#44; G&#243;mez-Flores M&#44; Gonz&#225;lez -Gonz&#225;lez SE&#44; Eguia-Rodr&#237;guez R&#44; M&#233;ndez-Olvera NP&#44; et al&#46; Evaluaci&#243;n cl&#237;nica e histol&#243;gica de imiquimod a 5&#37; en crema vs 5-fluorouracilo a 5&#37; en ung&#252;ento en pacientes con queratosis act&#237;nicas en la cara&#46; Dermatolog&#237;a Rev Mex&#46; 2010&#59;54&#58;326-331&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">44&#46; Otero V&#44; Bitar R&#44; Rodr&#237;guez G&#46; Tratamiento de la miliaria&#46; Estudio comparativo sobre el uso de azitromicina&#46; Rev Asoc Colomb Dermatol Cirug Dermatol&#46; 2000&#59;8&#58;249-254&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">45&#46; Pinto C&#44; Hasson A&#44; Gonz&#225;lez S&#44; Montoya J&#44; Droppelmann&#44; Inostroza ME&#44; et al&#46; Efecto de la terapia fotodin&#225;mica con metil aminolevulinato &#40;MAL&#41; comparada con luz roja en el tratamiento del acn&#233; inflamatorio leve a moderado&#46; Rev Chilena Dermatol&#46; 2011&#59;27&#58;177-187&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">46&#46; Prada S&#44; Salazar M&#44; Mu&#241;oz A&#44; &#193;lvarez L&#46; Tratamiento de &#250;lceras venosas con factores de crecimiento derivados de plaquetas aut&#243;logas&#46; Rev Asoc Colomb Dermatol Cirug Dermatol&#46; 2000&#59;8&#58;122-128&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">47&#46; Queiroz-Telles F&#44; Ribeiro-Santos L&#44; Santamaria J-R&#44; Nishino L&#44; Rocoo N-DO&#44; Milanez V&#44; Bastos C&#46; Tratamiento da onicomicose dermatofitica con itraconazol&#58; compara&#231;ao entre dos esquemas terap&#233;uticos&#46; Med Cutan Ibero Lat&#46; 1997&#59;25&#58;137-142&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">48&#46; Ram&#237;rez-Bosca A&#44; Zapater P&#44; Betlloch I&#44; Albero F&#44; Mart&#237;nez A&#44; D&#237;az-Alperi J&#44; et al&#46; Extracto de polypodium leucotomos en dermatitis at&#243;pica&#46; Ensayo multic&#233;ntrico aleatorizado&#44; doble ciego y controlado con placebo&#46; Actas Dermosifiliogr&#46; 2012&#59;103&#58;599-607&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">49&#46; Regis Roggero A&#44; Pancorbo Mendoza J&#44; Lanchipa Yokota P&#44; Regis Roggero RM&#44; Aguero M&#46; Tratamiento y reinfestaci&#243;n por escabiosis humana&#58; estudio comparativo entre permetrina al 5 por ciento vs benzoato de bencilo al 25 por ciento&#46; Dermatol Peru&#46; 2003&#59;13&#58;30-33&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">50&#46; R&#237;os Yuil JM&#44; R&#237;os Castro M&#46; Respuesta cl&#237;nica a las distintas modalidades terap&#233;uticas antif&#250;ngicas en pacientes hospitalizados con onicomicosis&#46; Dermatolog&#237;a Venezolana&#46; 2011&#59;49&#58;25-29&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">51&#46; Rodas Espinoza AF&#44; Enr&#237;quez-M J&#44; Alcal&#225;-P D&#44; Peralta-P ML&#46; Efectividad de la bleomicina intralesional para el tratamiento de pacientes con cicatrices queloides&#46; Estudio comparativo con dexametasona&#46; Dermatol Rev Mex&#46; 2011&#59;55&#58;119-126&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">52&#46; Rodr&#237;guez C&#44; S&#225;nchez L&#44; Minaya G&#44; Vasquez J&#44; Reymer D&#44; Macher C&#46; Tratamiento de las verrugas vulgares en ni&#241;os con la hemolinfa del insecto Epicauta sp&#46; Dermatol Peru&#46; 2000&#59;10&#58;94-96&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">53&#46; Rodr&#237;guez de Rivera-Campillo ME&#44; L&#243;pez-L&#243;pez J&#44; Chimenos-K&#252;stner E&#46; Tratamiento del s&#237;ndrome de boca ardiente con clonacepam t&#243;pico&#46; Piel&#46; 2011&#59;26&#58;263-268&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">54&#46; Rodr&#237;guez M&#44; Medina-Hern&#225;ndez E&#46; Estudio doble ciego&#44; comparativo&#44; sobre la eficacia y seguridad del crotamit&#243;n versus benzoato de bencilo en el tratamiento de la ros&#225;cea con demodicidosis&#46; Dermatol Rev Mex&#46; 2003&#59;47&#40;3&#41;&#58;126-130&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">55&#46; Rodr&#237;guez M&#46; Efectividad de dos pastas de aplicaci&#243;n oral &#40;amlexanox al 5&#37; y clobetasol propionato 0&#44;5&#37;&#41; en el tratamiento de &#250;lceras aftosas recurrentes menores&#46; Estudio cl&#237;nico controlado&#44; asignado aleatoriamente&#44; enmascarado multic&#233;ntrico&#46; Rev Asoc Colomb Dermatol Cirug Dermatol&#46; 2004&#59;12&#58;78&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">56&#46; Romero G&#44; Garc&#237;a M&#44; Vera E&#44; Mart&#237;nez C&#44; Cortina P&#44; S&#225;nchez P&#44; et al&#46; Resultados preliminares de DERMATEL&#58; estudio aleatorizado prospectivo comparando modalidades de teledermatolog&#237;a s&#237;ncrona y as&#237;ncrona Actas Dermosifiliogr&#46; 2006&#59;97&#58;630-636&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">57&#46; Ros&#243;n E&#44; Garc&#237;a Doval I&#44; Fl&#243;rez A&#44; Cruce M&#46; Estudio comparativo del tratamiento de la psoriasis en placas con ba&#241;o de PUVA y UVB de banda estrecha 311<span class="elsevierStyleHsp" style=""></span>nm&#46; Actas Dermosifiliogr&#46; 2005&#59;96&#58;371-375&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">58&#46; S&#225;ez M&#44; Guimer&#224; F&#44; Garc&#237;a M&#44; Dorta S&#44; Escoda M&#44; S&#225;nchez R&#44; et al&#46; Cloruro de aluminio hexahidratado en el tratamiento de las pustulosis palmoplantares Estudio preliminar&#46; Actas Dermosifiliogr&#46; 2000&#59;91&#58;416-469&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">59&#46; Salomone C&#44; C&#225;rdenas C&#44; Nicklas C&#44; P&#233;rez M-L&#46; La consejer&#237;a oral y escrita es un instrumento &#250;til para mejorar la adherencia al tratamiento a corto plazo en sujetos con acn&#233; vulgar&#58; ensayo cl&#237;nico randomizado simple ciego&#46; Rev Chil Dermatol&#46; 2009&#59;25&#40;4&#41;&#58;339-343&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">60&#46; S&#225;nchez M&#44; Iglesias M&#44; Umbert P&#46; Tratamiento de la psoriasis en placas con propiltiouracilo t&#243;pico&#46; Actas Dermosifiliogr&#46;2001&#59;92&#40;4&#41;&#58;174-176&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">61&#46; S&#225;nchez Dom&#237;nguez MC&#46; Estudio comparativo de la eficacia y seguridad del &#225;cido pir&#250;vico vs crioterapia en el tratamiento de verrugas plantares&#46; Dermatol Rev Mex&#46; 2003&#59;47&#58;219-231&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">62&#46; Tirado S&#225;nchez A&#44; Ponce Olivera RM&#46; Eficacia y tolerabilidad del &#223;-lipohidroxi&#225;cido en barra dermolimpiadora en el manejo del acn&#233; comed&#243;nico leve a moderado&#46; Dermatolog&#237;a CMQ&#46; 2009&#59;7&#40;2&#41;&#58;102-104&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">63&#46; Tirado-S&#225;nchez A&#44; Ponce-Olivera RM&#44; Montes de Oca-S&#225;nchez G&#44; Le&#243;n-Dorantes G&#46; Calidad de vida y s&#237;ntomas psicol&#243;gicos en pacientes con acn&#233; severo tratados con isotretino&#237;na&#46; Dermatol Rev Mex&#46; 2006&#59;50&#58;121-126&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">64&#46; Valbuena MC&#44; Gamboa LA&#46; Comparaci&#243;n de la eficacia del trimetroprim-sulfametoxazol con el clorhidrato de tetraciclina en el tratamiento de acn&#233; n&#243;dulo-qu&#237;stico&#46; Rev Asoc Colomb Dermatol Cirug Dermatol&#46; 1999&#59;7&#58;165-171&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">65&#46; Valverde-L&#243;pez J&#44; Lescano-Alva R&#46; Eficacia comparativa de esquemas terap&#233;uticos con cotrimoxazol en pediculosis capitis&#46; Dermatol Peru&#46; 2007&#59;17&#58;21-24&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">66&#46; V&#225;zquez Gonz&#225;lez D&#44; Fierro-Arias L&#44; Arellano-Mendoza I&#44; Tirado-S&#225;nchez A&#44; Peniche-Castellanos A&#46; Estudio comparativo entre el uso de ap&#243;sito hidrocoloide vs uso de tie-over para valorar el porcentaje de integraci&#243;n de los injertos cut&#225;neos de espesor total&#46; Dermatol Rev Mex&#46; 2011&#59;55&#58;175-179&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">67&#46; Vences Carranza M&#44; Rodr&#237;guez-Acar M&#46; Efecto acaricida del azufre octa&#233;drico&#44; tintura de yodo con &#225;cido salic&#237;lico y benzoato de bencilo en el tratamiento de la demodicidosis&#46; Dermatol Rev Mex&#46; 2004&#59;48&#58;121-126&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">68&#46; Vicu&#241;a-R&#237;os D&#44; Tincopa-Montoya L&#44; Valverde-L&#243;pez J&#44; Rojas-Plasencia P&#44; Tincopa-Wong O&#46; Eficacia de las cremas de ciclopirox 1&#37; y ketoconazol 2&#37; en el tratamiento de la dermatitis seborreica facial leve a moderada&#46; Dermatol Per&#250;&#46; 2005&#59;15&#58;25-29&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">69&#46; Vidal-Flores A&#44; Enr&#237;quez-Merino J&#46; Matricectom&#237;a parcial quir&#250;rgica vs matricectom&#237;a parcial con electrofulguraci&#243;n en el tratamiento de la onicocriptosis&#46; Dermatol Rev Mex&#46; 2006&#59;50&#58;54-59&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">70&#46; Villase&#241;or Ovies P&#44; Rebollo Dom&#237;nguez N&#44; Fern&#225;ndez Mart&#237;nez R&#44; Arenas Guzm&#225;n R&#44; Maga&#241;a C&#44; Soto Navarro M&#46; Comparaci&#243;n entre bifonazol y ketoconazol en el tratamiento de tinea pedis&#58; resultados de un ensayo cl&#237;nico&#46; Dermatolog&#237;a CMQ&#46; 2012&#59;10&#58;168-171&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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                    0 => array:2 [
                      "titulo" => "Inadequate size of &#8220;negative&#8221; clinical trials in dermatology"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
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                            1 => "P&#46; Seed"
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                    0 => array:1 [
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                        "tituloSerie" => "Br J Dermatol&#46;"
                        "fecha" => "1993"
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                        "paginaFinal" => "326"
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8471517"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "C&#243;mo mejorar la publicaci&#243;n de ensayos clinicos&#58; La declaraci&#243;n CONSORT"
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                        0 => array:2 [
                          "etal" => false
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                    0 => array:1 [
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                        "tituloSerie" => "Actas-Dermosifiliogr&#46;"
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                        "paginaInicial" => "141"
                        "paginaFinal" => "142"
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              "identificador" => "bib0135"
              "etiqueta" => "3"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Identificaci&#243;n y descripci&#243;n de los ensayos clinicos publicados en <span class="elsevierStyleSmallCaps">Actas Dermo-Sifiliograficas</span> entre 1948-2000"
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                            3 => "R&#46; Pedragosa-Jov&#233;"
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              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "How well are randomized controlled trials reported in the dermatology literature&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "K&#46; Adetugbo"
                            1 => "H&#46; Williams"
                          ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol&#46;"
                        "fecha" => "2000"
                        "volumen" => "136"
                        "paginaInicial" => "381"
                        "paginaFinal" => "385"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10724201"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0145"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Improving the quality of reporting of randomized controlled trials&#46; The CONSORT statement"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46; Begg"
                            1 => "M&#46; Cho"
                            2 => "S&#46; Eastwood"
                            3 => "R&#46; Horton"
                            4 => "D&#46; Moher"
                            5 => "I&#46; Olkin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA&#46;"
                        "fecha" => "1996"
                        "volumen" => "276"
                        "paginaInicial" => "637"
                        "paginaFinal" => "639"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8773637"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib0150"
              "etiqueta" => "6"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Does use of the CONSORT Statement impact the completeness of reporting of randomised controlled trials published in medical journals&#63; A Cochrane review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "L&#46; Turner"
                            1 => "L&#46; Shamseer"
                            2 => "D&#46;G&#46; Altman"
                            3 => "K&#46;F&#46; Schulz"
                            4 => "D&#46; Moher"
                          ]
                        ]
                      ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/2046-4053-1-60"
                      "Revista" => array:5 [
                        "tituloSerie" => "Syst Rev&#46;"
                        "fecha" => "2012"
                        "volumen" => "1"
                        "paginaInicial" => "60"
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                      "titulo" => "Identificaci&#243;n de ensayos cl&#237;nicos en revistas dermatol&#243;gicas publicadas en espa&#241;ol"
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                            "web" => "Medline"
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              "etiqueta" => "8"
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                      "titulo" => "The Cochrane Collaboration&#39;s tool for assessing risk of bias in randomised trials"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;P&#46; Higgins"
                            1 => "D&#46;G&#46; Altman"
                            2 => "P&#46;C&#46; G&#248;tzsche"
                            3 => "P&#46; J&#252;ni"
                            4 => "D&#46; Moher"
                            5 => "A&#46;D&#46; Oxman"
                          ]
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                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
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                        "tituloSerie" => "BMJ&#46;"
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                        "paginaInicial" => "d5928"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22008217"
                            "web" => "Medline"
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              "identificador" => "bib0165"
              "etiqueta" => "9"
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                    0 => array:2 [
                      "titulo" => "Ensayos cl&#237;nicos publicados en <span class="elsevierStyleItalic">Medicina Cutanea Ibero-latino-americana</span> entre 1970 y 2000"
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                          "autores" => array:1 [
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                      ]
                    ]
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            9 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Critical appraisal of reports on the treatment of perioral dermatitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "K&#46; Weber"
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                        "volumen" => "210"
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                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15942216"
                            "web" => "Medline"
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              "identificador" => "bib0175"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Efficacy and safety of systemic treatments for moderate-to-severe atopic dermatitis&#58; A systematic review"
                      "autores" => array:1 [
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                          "etal" => false
                          "autores" => array:5 [
                            0 => "E&#46; Roekevisch"
                            1 => "P&#46;I&#46; Spuls"
                            2 => "D&#46; Kuester"
                            3 => "J&#46; Limpens"
                            4 => "J&#46; Schmitt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaci.2013.07.049"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Allergy Clin Immunol&#46;"
                        "fecha" => "2014"
                        "volumen" => "133"
                        "paginaInicial" => "429"
                        "paginaFinal" => "438"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24269258"
                            "web" => "Medline"
                          ]
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                      ]
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                  ]
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              ]
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              "identificador" => "bib0180"
              "etiqueta" => "12"
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                0 => array:1 [
                  "referenciaCompleta" => "Williams H&#44; Bigby M&#46; The rationale for evidence-based dermatology&#46; In&#58; Williams H&#44; Bigby M&#44; Diepgen T&#44; Herxheimer A&#44; Naldi L&#44; Rzany B&#44; editors&#46; Evidence-based dermatology&#46; 2nd ed&#46; Oxford&#58; Blackwell Publishing&#59; 2003&#46; p&#46; 8-13&#46;"
                ]
              ]
            ]
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              "identificador" => "bib0185"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Measurement of health-related quality of life in dermatological research and practice&#58; Outcome of the EADV Taskforce on Quality of Life"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            2 => "M&#46; Augustin"
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                            4 => "S&#46;S&#46; Salek"
                            5 => "M&#46;K&#46; Basra"
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                      ]
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                  ]
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                    0 => array:2 [
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                        "tituloSerie" => "J Eur Acad Dermatol Venereol&#46;"
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                        "link" => array:1 [
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23301583"
                            "web" => "Medline"
                          ]
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                    ]
                  ]
                ]
              ]
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              "identificador" => "bib0190"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Why measure quality of life in dermatology&#63;"
                      "autores" => array:1 [
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                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46; Abeni"
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                          ]
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                      ]
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                  ]
                  "host" => array:1 [
                    0 => array:1 [
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                        "tituloSerie" => "G Ital Dermatol Venereol&#46;"
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                        "paginaInicial" => "237"
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                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23670059"
                            "web" => "Medline"
                          ]
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              "identificador" => "bib0195"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impact of different skin conditions on quality of life"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "F&#46; Sampogna"
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                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
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                            "web" => "Medline"
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              "identificador" => "bib0200"
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                0 => array:3 [
                  "comentario" => "MR300000"
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Consolidated standards of reporting trials &#40;CONSORT&#41; and the completeness of reporting of randomised controlled trials &#40;RCTs&#41; published in medical journals"
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                        0 => array:2 [
                          "etal" => true
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                            2 => "D&#46;G&#46; Altman"
                            3 => "L&#46; Weeks"
                            4 => "J&#46; Peters"
                            5 => "T&#46; Kober"
                          ]
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                        "fecha" => "2012"
                        "volumen" => "11"
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                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27886368"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0205"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Does journal endorsement of reporting guidelines influence the completeness of reporting of health research&#63; A systematic review protocol"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            3 => "L&#46; Turner"
                            4 => "D&#46;G&#46; Altman"
                            5 => "A&#46; Hirst"
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                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22626029"
                            "web" => "Medline"
                          ]
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                  ]
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              ]
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              "identificador" => "bib0210"
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                0 => array:1 [
                  "referenciaCompleta" => "Als-Nielsen B&#44; Gluud L&#44; Gluud C&#46; Methodological quality and treatment effects in randomised trials&#58; a review of six empirical studies&#46; 12th Cochrane Colloquium&#46; Ottawa&#44; Ontario&#44; Canada&#59; 2004&#46;"
                ]
              ]
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            18 => array:3 [
              "identificador" => "bib0215"
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              "referencia" => array:1 [
                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Caracter&#237;sticas y calidad metodol&#243;gica de los ensayos cl&#237;nicos publicados en la <span class="elsevierStyleItalic">Revista Espa&#241;ola de Anestesiolog&#237;a y Reanimaci&#243;n</span>"
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                        0 => array:2 [
                          "etal" => false
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                            3 => "X&#46; Bonfill"
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                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Esp Anestesiol Reanim&#46;"
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                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17695943"
                            "web" => "Medline"
                          ]
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              "identificador" => "bib0220"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Relationship between conflicts of interest and research results"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "L&#46;S&#46; Friedman"
                            1 => "E&#46;D&#46; Richter"
                          ]
                        ]
                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Gen Intern Med&#46;"
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                        "paginaFinal" => "56"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14748860"
                            "web" => "Medline"
                          ]
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                  ]
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Positioning of scientific societies and working groups reviews&#58; statement on conflicts of interest and need for transparency"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
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                            2 => "I&#46; Martinez Nimatuj"
                            3 => "F&#46; Galv&#225;n Lago"
                          ]
                        ]
                      ]
                    ]
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                  "host" => array:1 [
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                  "referenciaCompleta" => "Ruano A&#46; El conflicto de intereses econ&#243;mico de las asociaciones profesionales sanitarias con la industria sanitaria&#46; Sociedad Espa&#241;ola de Salud P&#250;blica y Administraci&#243;n Sanitaria &#40;SESPAS&#41;&#59; 2011&#46;"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Problems in the reporting of acne clinical trials&#58; a spot check from the 2009 Annual Evidence Update on Acne Vulgaris"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
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                            2 => "H&#46;C&#46; Williams"
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                    ]
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                        "tituloSerie" => "Trials&#46;"
                        "fecha" => "2010"
                        "volumen" => "11"
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20624287"
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                    0 => array:2 [
                      "titulo" => "Strengths and limitations of evidence-based dermatology"
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                          "autores" => array:1 [
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                      "doi" => "10.4103/0019-5154.127670"
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                        "tituloSerie" => "Indian J Dermatol&#46;"
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                        "paginaInicial" => "127"
                        "paginaFinal" => "133"
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        "texto" => "<p id="par0180" class="elsevierStylePara elsevierViewall">We would like to acknowledge with thanks the work of all the students enrolled in the public health Masters degree program at the Universitat Aut&#242;noma de Barcelona for their help in identifying the dermatology journals&#46; Thanks are also due to Ivan Sol&#224; of the Iberoamerican Cochrane Centre for his advice on the search process and his critical reading of the manuscript&#46; We would also like to express our gratitude to Elizabeth Dussan and Nelly Pinz&#243;n &#40;Colombian Association of Dermatology&#41;&#44; to Karina Vielma and Dr&#46; Mar&#237;a Isabel Herane &#40;Chilean Dermatology Society&#41;&#44; to Dr&#46; Alexandro Bonifax <span class="elsevierStyleItalic">&#40;Revista Dermatolog&#237;a Mexicana&#41;</span>&#44; to Dr&#46; Roberto Arenas and Dr&#46; Jorge Ocampo-Candiani &#40;<span class="elsevierStyleItalic">Revista Dermatolog&#237;a Cosm&#233;tica M&#233;dica y Quir&#250;rgica</span>&#41;&#44; and to Dr&#46; Edgardo Chouela for their help in the search and in sending full texts of the articles we requested&#46;</p> <p id="par0185" class="elsevierStylePara elsevierViewall">Dr&#46; Gloria Sanclemente is a PhD candidate in the department of pediatrics&#44; obstetrics&#44; gynecology&#44; and preventive medicine of the Universitat Aut&#243;noma de Barcelona&#44; Spain&#46; This study was carried out with the help of the Group of Investigative Dermatology &#40;GRID&#41; of the Universidad de Antioquia&#44; Medell&#237;n&#44; Colombia&#46;</p>"
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