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"tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "846" "paginaFinal" => "848" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Are We Examining Our Patients Properly and Can We Do a Better Job?" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 788 "Ancho" => 900 "Tamanyo" => 111356 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Imagen del tumor primario en el paciente con metástasis ganglionares de melanoma en la región inguinal izquierda. Se aprecia una lesión pigmentada oscura y queratósica de 1,5<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>1<span class="elsevierStyleHsp" style=""></span>cm, con signo de Hutchinson, en el pulpejo del quinto dedo del pie izquierdo.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M. Ivars, P. Redondo" "autores" => array:2 [ 0 => array:2 [ "nombre" => "M." "apellidos" => "Ivars" ] 1 => array:2 [ "nombre" => "P." 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"apellidos" => "Requena" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731015003269" "doi" => "10.1016/j.ad.2015.06.006" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015003269?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015002668?idApp=UINPBA000044" "url" => "/15782190/0000010600000010/v1_201512060022/S1578219015002668/v1_201512060022/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S1578219015002620" "issn" => "15782190" "doi" => "10.1016/j.adengl.2015.10.002" "estado" => "S300" "fechaPublicacion" => "2015-12-01" "aid" => "1212" "copyright" => "Elsevier España, S.L.U. and AEDV" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2015;106:843-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1619 "formatos" => array:3 [ "EPUB" => 45 "HTML" => 1146 "PDF" => 428 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>" "titulo" => "Mixed Connective Tissue Disease in a Patient With Castleman Disease and Hodgkin Lymphoma: Excellent Clinical Response to Rituximab" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "843" "paginaFinal" => "846" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Enfermedad mixta del tejido conectivo en el contexto de enfermedad de Castleman y linfoma Hodgkin con excelente respuesta clínica a rituximab" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 731 "Ancho" => 900 "Tamanyo" => 203216 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Basal layer vacuolization and thickening of the basement membrane (periodic acid-Schiff ×20).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "T. 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"tieneTextoCompleto" => true "saludo" => "<span class="elsevierStyleItalic">To the editor:</span>" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "846" "paginaFinal" => "848" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "M. Ivars, P. Redondo" "autores" => array:2 [ 0 => array:4 [ "nombre" => "M." "apellidos" => "Ivars" "email" => array:2 [ 0 => "mivars@unav.es" 1 => "martaivars@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "P." "apellidos" => "Redondo" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Departamento de Dermatología, Clínica Universidad de Navarra, Pamplona, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "¿Exploramos correctamente a los pacientes? ¿Qué nos está pasando?" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 788 "Ancho" => 900 "Tamanyo" => 121487 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Image of the primary tumor in the patient with lymph node metastases in the left groin. A dark, kerotic pigmented lesion measuring 1.5<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>1<span class="elsevierStyleHsp" style=""></span>cm can be seen, with the Hutchinson sign, on the ball of the left little toe.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Melanoma remains a prominent health concern. It is one of the most frequent tumors in young adults.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">1</span></a> The incidence and associated mortality has increased in recent decades.<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">2–4</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Although metastatic melanoma can only be cured on limited occasions, new immunotherapy treatments<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">5–7</span></a> (for example, high-dose IL-2, ipilimumab [anti-cytotoxic T-lymphocyte antigen 4], pembrolizumab, and nivolumab [anti-programmed cell death 1], etc.) and combination treatments for specific mutations<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">8,9</span></a> (BRAF, mitogen-activated protein kinase [MEK], and c-KIT inhibitors) have increased survival for patients with stage <span class="elsevierStyleSmallCaps">iii</span> and <span class="elsevierStyleSmallCaps">iv</span> disease. At times, melanoma is diagnosed in an advanced phase and a primary tumor is not detected despite exhaustive study. Metastatic melanoma from an unknown primary tumor is defined as the histologically confirmed presence of melanoma in a lymph node, organ, or other tissue without history or evidence of a primary skin, mucosal, or ocular lesion. These metastatic lesions are estimated to comprise 3.2% of all melanomas and they seem to have a better prognosis than those metastatic lesions of known origin.<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">10</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">We present the cases of 2 patients seen initially in tertiary hospitals with metastatic melanoma of unknown origin who sought a second opinion in our hospital.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Case Histories</span><p id="par0020" class="elsevierStylePara elsevierViewall">A 67-year-old man was seen in his local hospital with swollen lymph nodes in his left groin. After histologic and immunohistochemical study of one of the swollen lymph nodes, metastatic melanoma of unknown origin was diagnosed. The patient was assessed by an oncologist and a dermatologist, who were unable to locate the primary melanoma. Given that immunotherapy treatment was contraindicated and the BRAF mutation was absent, he received 3 chemotherapy sessions for several months. We are awaiting a reduction in the inguinal mass before palliative lymphadenectomy.</p><p id="par0025" class="elsevierStylePara elsevierViewall">By coincidence, in the same week, we assessed the second patient. He was 45 years old, and had a large and rapidly growing tumor in the left laterocervical region that prompted him to attend his reference hospital. Histologic and immunohistochemical study of the mass pointed to diagnosis of metastatic melanoma. The lesion was positive for the BRAF mutation. In the study of extension by computed tomography-positron emission tomography, lymph node metastases were also found at other sites. After multidisciplinary assessment by an oncologist, a dermatologist, an ear-nose-throat specialist, and a ophthalmologist, he was diagnosed with metastatic melanoma of unknown origin and prescribed treatment with a BRAF inhibitor (vemurafenib) and a MEK inhibitor (trametinib).</p><p id="par0030" class="elsevierStylePara elsevierViewall">After taking the medical history and the physical examination of the patients, the primary tumor was located in both patients: the first patient had a dark, keratotic pigmented lesion measuring 1.5<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>1<span class="elsevierStyleHsp" style=""></span>cm, with the Hutchinson sign, on the ball of the left big toe (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). The second patient had a hyperpigmented lesion measuring 2<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>1.5<span class="elsevierStyleHsp" style=""></span>cm in diameter in the left parietal region, with a characteristic atypical dermoscopic pattern (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). In both cases, the lesion was evident and was located on a region of the skin that should be examined given the site of the lymph node metastasis. Certain care in the examination was, however, required because the lesion was located on an area of the scalp covered by hair in one case and in the acral most part of the body in the other.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">We present 2 cases that may well reflect other avoidable situations in dermatology departments in our hospitals. Although this may appear a diagnostic omission and would have no bearing on the follow-up and therapeutic approach, prognosis does vary according to whether the primary tumor is known or unknown.<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">10</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">A detailed medical history and careful physical examination are the basis for diagnosis. A study in the United States concluded that the percentage of dermatologists who perform a complete examination of patients with risk factors for melanoma does not exceed 50%.<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">11</span></a> Other studies highlight how a complete body examination can assist in early diagnosis of a high percentage of melanomas in patients who attend the clinic for another reason.<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">12–18</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">In view of the above, the physical examination of the patient in a melanoma unit should be protocolized and meticulous. First, the patient should be examined completely naked, with appropriate light sources, if possible with natural light. The whole body surface should be examined, without omitting the acral areas and those not readily accessible for some patients (retroauricular area, interdigital area, and soles of the feet, etc.). The mucosas (oral, genital, conjunctival, etc.) and appendages (nails and areas with hair follicles) should also be examined. When the patient has been diagnosed with metastatic melanoma of unknown primary tumor, an exhaustive examination of the area of skin drained by the affected lymph node should be undertaken.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Case Histories" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Ivars M, Redondo P. ¿Exploramos correctamente a los pacientes? ¿Qué nos está pasando?. Actas Dermosifiliogr. 2015;106:846–848.</p>" ] ] "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 788 "Ancho" => 900 "Tamanyo" => 121487 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Image of the primary tumor in the patient with lymph node metastases in the left groin. A dark, kerotic pigmented lesion measuring 1.5<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>1<span class="elsevierStyleHsp" style=""></span>cm can be seen, with the Hutchinson sign, on the ball of the left little toe.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1203 "Ancho" => 900 "Tamanyo" => 223334 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Lymph node metastases in the left laterocervical region (gray arrow) and primary tumor (hyperpigmented lesion measuring 2<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>1.5<span class="elsevierStyleHsp" style=""></span>cm in diameter with a characteristic atypical dermoscopic pattern) in the left parietal region (white arrows).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:18 [ 0 => array:3 [ "identificador" => "bib0095" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cancer statistics, 2005" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. 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Year/Month | Html | Total | |
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2024 November | 4 | 7 | 11 |
2024 October | 59 | 40 | 99 |
2024 September | 49 | 30 | 79 |
2024 August | 83 | 54 | 137 |
2024 July | 73 | 29 | 102 |
2024 June | 76 | 19 | 95 |
2024 May | 54 | 24 | 78 |
2024 April | 68 | 26 | 94 |
2024 March | 59 | 26 | 85 |
2024 February | 64 | 43 | 107 |
2024 January | 44 | 35 | 79 |
2023 December | 50 | 21 | 71 |
2023 November | 56 | 30 | 86 |
2023 October | 56 | 26 | 82 |
2023 September | 59 | 26 | 85 |
2023 August | 36 | 17 | 53 |
2023 July | 34 | 54 | 88 |
2023 June | 41 | 28 | 69 |
2023 May | 51 | 26 | 77 |
2023 April | 33 | 28 | 61 |
2023 March | 41 | 23 | 64 |
2023 February | 39 | 17 | 56 |
2023 January | 29 | 28 | 57 |
2022 December | 44 | 36 | 80 |
2022 November | 36 | 24 | 60 |
2022 October | 48 | 23 | 71 |
2022 September | 63 | 29 | 92 |
2022 August | 41 | 34 | 75 |
2022 July | 22 | 34 | 56 |
2022 June | 30 | 35 | 65 |
2022 May | 26 | 32 | 58 |
2022 April | 27 | 30 | 57 |
2022 March | 32 | 40 | 72 |
2022 February | 16 | 24 | 40 |
2022 January | 39 | 26 | 65 |
2021 December | 21 | 30 | 51 |
2021 November | 39 | 41 | 80 |
2021 October | 37 | 55 | 92 |
2021 September | 35 | 36 | 71 |
2021 August | 18 | 37 | 55 |
2021 July | 20 | 27 | 47 |
2021 June | 22 | 23 | 45 |
2021 May | 31 | 26 | 57 |
2021 April | 54 | 36 | 90 |
2021 March | 72 | 22 | 94 |
2021 February | 36 | 18 | 54 |
2021 January | 32 | 17 | 49 |
2020 December | 28 | 13 | 41 |
2020 November | 22 | 21 | 43 |
2020 October | 21 | 17 | 38 |
2020 September | 22 | 7 | 29 |
2020 August | 27 | 22 | 49 |
2020 July | 24 | 15 | 39 |
2020 June | 48 | 27 | 75 |
2020 May | 35 | 18 | 53 |
2020 April | 50 | 21 | 71 |
2020 March | 63 | 22 | 85 |
2020 February | 5 | 5 | 10 |
2020 January | 0 | 1 | 1 |
2019 December | 4 | 2 | 6 |
2019 September | 5 | 4 | 9 |
2019 August | 4 | 4 | 8 |
2019 July | 0 | 2 | 2 |
2019 June | 0 | 2 | 2 |
2019 May | 3 | 2 | 5 |
2019 April | 0 | 5 | 5 |
2019 March | 2 | 4 | 6 |
2019 February | 0 | 3 | 3 |
2018 December | 3 | 8 | 11 |
2018 November | 4 | 0 | 4 |
2018 October | 7 | 0 | 7 |
2018 September | 6 | 0 | 6 |
2018 February | 21 | 4 | 25 |
2018 January | 24 | 4 | 28 |
2017 December | 38 | 6 | 44 |
2017 November | 23 | 4 | 27 |
2017 October | 19 | 7 | 26 |
2017 September | 26 | 6 | 32 |
2017 August | 22 | 7 | 29 |
2017 July | 19 | 9 | 28 |
2017 June | 28 | 15 | 43 |
2017 May | 18 | 6 | 24 |
2017 April | 24 | 9 | 33 |
2017 March | 10 | 35 | 45 |
2017 February | 18 | 10 | 28 |
2017 January | 9 | 6 | 15 |
2016 December | 26 | 12 | 38 |
2016 November | 26 | 15 | 41 |
2016 October | 25 | 25 | 50 |
2016 August | 0 | 1 | 1 |
2016 July | 0 | 1 | 1 |
2016 June | 1 | 1 | 2 |
2016 May | 0 | 4 | 4 |
2016 February | 0 | 1 | 1 |
2016 January | 0 | 1 | 1 |