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ovoid cells with round nuclei in a hyaline stroma&#59; other areas of myxoid appearance with lower cellularity&#59; and moderate diffuse positivity for protein S-100 &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; The surgical margins were not extended in either case&#46; No signs of local recurrence or metastases have been detected after follow-up of 18 years and 21 months&#44; respectively&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">This tumor typically affects men&#44; and the mean age at presentation is 50 years&#46; It usually arises in the proximal regions of the limbs&#44; most commonly the lower limbs&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">1&#44;3&#8211;6</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Immunohistochemistry closely reflects the controversy regarding the histogenesis of the tumor&#46; The origins that have been postulated with greatest emphasis are Schwann cells &#40;because of the existence of well-developed&#44; duplicated basal lamina and positivity for protein S-100<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">7</span></a>&#41; and cartilage &#40;due to the presence of irregular cell borders with small projections and intracellular microfillaments with positivity for S-100<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a>&#41;&#46; Other authors have suggested a myoepithelial lineage based on ultrastructural findings&#44;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">4</span></a> or neuronal lineage due to positivity for CD56&#44; a neural adhesion molecule&#44; and for EAAT4&#44; a neuronal glutamic acid transporter&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">3</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Cytogenetic analysis of this type of tumor focuses attention on 2 genes&#44; <span class="elsevierStyleItalic">INI-1</span>&#44;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">3</span></a> a tumor suppressor gene&#44; and <span class="elsevierStyleItalic">PHF1</span>&#44;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">8</span></a> which codes for a protein that&#44; among other functions&#44; regulates the activity of the polycomb-repressive complex 2&#44; which silences genes responsible for development&#46; Dysregulation of this complex&#44; secondary to changes in these or other adjacent genes&#44; has been suggested as a mechanism of development of OFMTs&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">In 1995&#44; Kilpatrick<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">9</span></a> was the first to describe the existence of OFMTs with a malignant behavior&#44; associated with atypical morphological findings&#46; Folpe and Weiss<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">6</span></a> identified criteria predictive of an aggressive or malignant behavior&#46; Subsequently&#44; Miettinen<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">5</span></a> rejected the existence of malignant OFMTs&#44; stating that the majority of those tumors did not satisfy the classic description of OFMTs and could be better classified as other types of sarcoma&#46; Graham&#44;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">3</span></a> continuing the work initiated by Folpe&#44; validated their classification on finding that the malignant subtype was associated with a more aggressive behavior during follow-up&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">A biologically aggressive behavior was also investigated in the largest series of OFMTs&#46; Folpe<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">6</span></a> detected local recurrence in 18&#37; and metastases in 16&#37;&#46; Miettinen&#44;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">5</span></a> including only typical OFMTs&#44; reported local recurrence in 22&#37; and no cases of metastasis&#46; Finally&#44; Graham<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">3</span></a> reported local recurrence rates of 4&#46;3&#37; and metastasis in 6&#46;5&#37;&#44; considering only malignant OFMTs&#46; Grouping the data from those series&#44; the metastatic risk of the typical variant is less than 5&#37;&#59; this indicates that&#44; even if benign histological characteristics are observed&#44; OFMT can give rise to metastases&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The scarcity of OFMTs recruited in the past 20 years in our hospital&#44; given that the catchment population is close to 1 million&#44; would appear to be related to a diagnostic vision closer to that of Miettinen than to Folpe and Graham&#46; Thus&#44; tumors that do not fit the typical description of OFMTs&#44; and that showed characteristics of malignancy&#44; were classified as low-grade sarcomas rather than as malignant OFMTs&#46; This could explain the absence of recurrence in either of our 2 patients&#44; despite having performed excisions with narrow margins&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">In conclusion&#44; OFMT is a rare disease&#44; whose epidemiology may be biased by the diagnostic considerations of each pathology departament regarding atypical and malignant variants&#46; Despite showing benign characteristics&#44; these tumors can present aggressive behavior&#44; and they should not therefore be classified as benign&#44; but rather considered as tumors of intermediate malignancy&#46;</p></span>"
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        "texto" => "<p id="par0050" class="elsevierStylePara elsevierViewall">We would like to thank Drs&#46; Jos&#233; Juan Pozo-Kreilinger&#44; Adrien Yvon&#44; and Estefania Alonso-Rodr&#237;guez for their close collaboration&#44; which made this study possible&#46;</p>"
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Case and Research Letters
Histologic diagnosis of ossifying fibromyxoid tumor: 2 cases in the past 20 Years
Diagnóstico histológico del tumor fibromixoide osificante: 2 casos en los últimos 20 años
J. Hernández-Godoy
Corresponding author
jhdezgodoy@gmail.com

Corresponding author.
, C. Casado-Sánchez, L. Landín, A.A. Rosell
Servicio de Cirugía Plástica, Hospital Universitario La Paz, Madrid, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The ossifying fibromyxoid tumor &#40;OFMT&#41; was originally described as a small benign tumor of the subcutaneous tissue&#46; It is formed of small cells arranged in cords and nests in a fibromyxoid stroma&#44; covered by a bony capsule&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a> However&#44; recent publications have reported histologic findings of malignancy associated with metastatic disease&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">2</span></a> There is controversy regarding the histologic origin of the tumor&#46; Despite initially being considered to be distinct from schwannian or cartilaginous tumors&#44;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a> based on ultrastructural and immunohistochemical characteristics &#40;positivity for protein S-100&#41;&#44; more recent proteomic and genetic analyses support a neuronal or myoepithelial origin&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">3&#44;4</span></a> In the last decade&#44; the idea that malignant OFMTs do not exist has been proposed&#44; as they do not satisfy the traditional histological description&#44; and could correspond to other malignant soft tissue tumors&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">5</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">In the last 20 years&#44; 2 cases of OFMT have been identified in our hospital&#44; one on the scalp of a 55-year-old man the other on the hand of a 46-year-old man &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The tumors were painless&#46; Histology of the excisional biopsies were consistent with the classic description of OFMT&#58; well-defined capsule&#59; areas of fibrosis formed of laminae of uniform&#44; ovoid cells with round nuclei in a hyaline stroma&#59; other areas of myxoid appearance with lower cellularity&#59; and moderate diffuse positivity for protein S-100 &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; The surgical margins were not extended in either case&#46; No signs of local recurrence or metastases have been detected after follow-up of 18 years and 21 months&#44; respectively&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">This tumor typically affects men&#44; and the mean age at presentation is 50 years&#46; It usually arises in the proximal regions of the limbs&#44; most commonly the lower limbs&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">1&#44;3&#8211;6</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Immunohistochemistry closely reflects the controversy regarding the histogenesis of the tumor&#46; The origins that have been postulated with greatest emphasis are Schwann cells &#40;because of the existence of well-developed&#44; duplicated basal lamina and positivity for protein S-100<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">7</span></a>&#41; and cartilage &#40;due to the presence of irregular cell borders with small projections and intracellular microfillaments with positivity for S-100<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a>&#41;&#46; Other authors have suggested a myoepithelial lineage based on ultrastructural findings&#44;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">4</span></a> or neuronal lineage due to positivity for CD56&#44; a neural adhesion molecule&#44; and for EAAT4&#44; a neuronal glutamic acid transporter&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">3</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Cytogenetic analysis of this type of tumor focuses attention on 2 genes&#44; <span class="elsevierStyleItalic">INI-1</span>&#44;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">3</span></a> a tumor suppressor gene&#44; and <span class="elsevierStyleItalic">PHF1</span>&#44;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">8</span></a> which codes for a protein that&#44; among other functions&#44; regulates the activity of the polycomb-repressive complex 2&#44; which silences genes responsible for development&#46; Dysregulation of this complex&#44; secondary to changes in these or other adjacent genes&#44; has been suggested as a mechanism of development of OFMTs&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">In 1995&#44; Kilpatrick<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">9</span></a> was the first to describe the existence of OFMTs with a malignant behavior&#44; associated with atypical morphological findings&#46; Folpe and Weiss<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">6</span></a> identified criteria predictive of an aggressive or malignant behavior&#46; Subsequently&#44; Miettinen<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">5</span></a> rejected the existence of malignant OFMTs&#44; stating that the majority of those tumors did not satisfy the classic description of OFMTs and could be better classified as other types of sarcoma&#46; Graham&#44;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">3</span></a> continuing the work initiated by Folpe&#44; validated their classification on finding that the malignant subtype was associated with a more aggressive behavior during follow-up&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">A biologically aggressive behavior was also investigated in the largest series of OFMTs&#46; Folpe<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">6</span></a> detected local recurrence in 18&#37; and metastases in 16&#37;&#46; Miettinen&#44;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">5</span></a> including only typical OFMTs&#44; reported local recurrence in 22&#37; and no cases of metastasis&#46; Finally&#44; Graham<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">3</span></a> reported local recurrence rates of 4&#46;3&#37; and metastasis in 6&#46;5&#37;&#44; considering only malignant OFMTs&#46; Grouping the data from those series&#44; the metastatic risk of the typical variant is less than 5&#37;&#59; this indicates that&#44; even if benign histological characteristics are observed&#44; OFMT can give rise to metastases&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The scarcity of OFMTs recruited in the past 20 years in our hospital&#44; given that the catchment population is close to 1 million&#44; would appear to be related to a diagnostic vision closer to that of Miettinen than to Folpe and Graham&#46; Thus&#44; tumors that do not fit the typical description of OFMTs&#44; and that showed characteristics of malignancy&#44; were classified as low-grade sarcomas rather than as malignant OFMTs&#46; This could explain the absence of recurrence in either of our 2 patients&#44; despite having performed excisions with narrow margins&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">In conclusion&#44; OFMT is a rare disease&#44; whose epidemiology may be biased by the diagnostic considerations of each pathology departament regarding atypical and malignant variants&#46; Despite showing benign characteristics&#44; these tumors can present aggressive behavior&#44; and they should not therefore be classified as benign&#44; but rather considered as tumors of intermediate malignancy&#46;</p></span>"
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ISSN: 15782190
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