array:24 [
  "pii" => "S1578219015002383"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2015.09.003"
  "estado" => "S300"
  "fechaPublicacion" => "2015-11-01"
  "aid" => "1206"
  "copyright" => "Elsevier España, S.L.U. and AEDV"
  "copyrightAnyo" => "2015"
  "documento" => "article"
  "crossmark" => 1
  "subdocumento" => "fla"
  "cita" => "Actas Dermosifiliogr. 2015;106:740-5"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 836
    "formatos" => array:3 [
      "EPUB" => 44
      "HTML" => 441
      "PDF" => 351
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0001731015002756"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2015.05.010"
      "estado" => "S300"
      "fechaPublicacion" => "2015-11-01"
      "aid" => "1206"
      "copyright" => "Elsevier España, S.L.U. and AEDV"
      "documento" => "article"
      "crossmark" => 1
      "subdocumento" => "fla"
      "cita" => "Actas Dermosifiliogr. 2015;106:740-5"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 1028
        "formatos" => array:3 [
          "EPUB" => 2
          "HTML" => 255
          "PDF" => 771
        ]
      ]
      "es" => array:12 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Original</span>"
        "titulo" => "S&#237;filis en hombres que tienen sexo con hombres&#58; una alarma para la detecci&#243;n de infecci&#243;n por VIH"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "tieneResumen" => array:2 [
          0 => "es"
          1 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "740"
            "paginaFinal" => "745"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Syphilis in Men Who Have Sex With Men&#58; A Warning Sign for HIV Infection"
          ]
        ]
        "contieneResumen" => array:2 [
          "es" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "C&#46; G&#225;llego-Lez&#225;un, M&#46; Arrizabalaga Asenjo, J&#46; Gonz&#225;lez-Moreno, I&#46; Ferullo, A&#46; Teslev, V&#46; Fern&#225;ndez-Vaca, A&#46; Payeras Cifre"
            "autores" => array:7 [
              0 => array:2 [
                "nombre" => "C&#46;"
                "apellidos" => "G&#225;llego-Lez&#225;un"
              ]
              1 => array:2 [
                "nombre" => "M&#46;"
                "apellidos" => "Arrizabalaga Asenjo"
              ]
              2 => array:2 [
                "nombre" => "J&#46;"
                "apellidos" => "Gonz&#225;lez-Moreno"
              ]
              3 => array:2 [
                "nombre" => "I&#46;"
                "apellidos" => "Ferullo"
              ]
              4 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Teslev"
              ]
              5 => array:2 [
                "nombre" => "V&#46;"
                "apellidos" => "Fern&#225;ndez-Vaca"
              ]
              6 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Payeras Cifre"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219015002383"
          "doi" => "10.1016/j.adengl.2015.09.003"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015002383?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015002756?idApp=UINPBA000044"
      "url" => "/00017310/0000010600000009/v1_201511040159/S0001731015002756/v1_201511040159/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1578219015002425"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2015.09.007"
    "estado" => "S300"
    "fechaPublicacion" => "2015-11-01"
    "aid" => "1205"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "fla"
    "cita" => "Actas Dermosifiliogr. 2015;106:746-52"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1028
      "formatos" => array:3 [
        "EPUB" => 55
        "HTML" => 720
        "PDF" => 253
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">ORIGINAL</span>"
      "titulo" => "Cross-Cultural Adaptation of the Urticaria Control Test From German to Castilian Spanish"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "746"
          "paginaFinal" => "752"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Adaptaci&#243;n transcultural del cuestionario <span class="elsevierStyleItalic">Urticaria Control Test</span> del alem&#225;n al castellano"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1944
              "Ancho" => 2452
              "Tamanyo" => 418893
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Flow chart of work required for the cross-cultural adaptation of the Urticaria Control Test &#40;UCT&#41; to Castillian Spanish for use in Spain&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "I&#46; Garc&#237;a-D&#237;ez, L&#46; Curto-Barredo, K&#46; Weller, R&#46;M&#46; Pujol, M&#46; Maurer, A&#46;M&#46; Gim&#233;nez-Arnau"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "I&#46;"
              "apellidos" => "Garc&#237;a-D&#237;ez"
            ]
            1 => array:2 [
              "nombre" => "L&#46;"
              "apellidos" => "Curto-Barredo"
            ]
            2 => array:2 [
              "nombre" => "K&#46;"
              "apellidos" => "Weller"
            ]
            3 => array:2 [
              "nombre" => "R&#46;M&#46;"
              "apellidos" => "Pujol"
            ]
            4 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Maurer"
            ]
            5 => array:2 [
              "nombre" => "A&#46;M&#46;"
              "apellidos" => "Gim&#233;nez-Arnau"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731015002744"
        "doi" => "10.1016/j.ad.2015.05.009"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015002744?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015002425?idApp=UINPBA000044"
    "url" => "/15782190/0000010600000009/v1_201511040157/S1578219015002425/v1_201511040157/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1578219015002413"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2015.09.006"
    "estado" => "S300"
    "fechaPublicacion" => "2015-11-01"
    "aid" => "1215"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "fla"
    "cita" => "Actas Dermosifiliogr. 2015;106:733-9"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1135
      "formatos" => array:3 [
        "EPUB" => 59
        "HTML" => 728
        "PDF" => 348
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>"
      "titulo" => "Otologic Manifestations of Autosomal Recessive Congenital Ichthyosis in Children"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "733"
          "paginaFinal" => "739"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Manifestaciones otol&#243;gicas en los ni&#241;os con ictiosis cong&#233;nitas autos&#243;micas recesivas"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1462
              "Ancho" => 3001
              "Tamanyo" => 591377
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Case 4&#46; A&#44; Collodion baby phenotype at 24<span class="elsevierStyleHsp" style=""></span>hours old&#46; B&#44; Marked ectropion at 3 weeks of age&#46; C&#44; Lamellar ichthyosis phenotype at 4 years of age&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "A&#46; Mart&#237;n-Santiago, M&#46; Rodr&#237;guez-Pascual, N&#46; Kn&#246;pfel, &#193;&#46; Hern&#225;ndez-Mart&#237;n"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Mart&#237;n-Santiago"
            ]
            1 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Rodr&#237;guez-Pascual"
            ]
            2 => array:2 [
              "nombre" => "N&#46;"
              "apellidos" => "Kn&#246;pfel"
            ]
            3 => array:2 [
              "nombre" => "&#193;&#46;"
              "apellidos" => "Hern&#225;ndez-Mart&#237;n"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731015002872"
        "doi" => "10.1016/j.ad.2015.06.003"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015002872?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015002413?idApp=UINPBA000044"
    "url" => "/15782190/0000010600000009/v1_201511040157/S1578219015002413/v1_201511040157/en/main.assets"
  ]
  "en" => array:19 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original</span>"
    "titulo" => "Syphilis in Men Who Have Sex With Men&#58; A Warning Sign for HIV Infection"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "740"
        "paginaFinal" => "745"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "C&#46; G&#225;llego-Lez&#225;un, M&#46; Arrizabalaga Asenjo, J&#46; Gonz&#225;lez-Moreno, I&#46; Ferullo, A&#46; Teslev, V&#46; Fern&#225;ndez-Vaca, A&#46; Payeras Cifre"
        "autores" => array:7 [
          0 => array:4 [
            "nombre" => "C&#46;"
            "apellidos" => "G&#225;llego-Lez&#225;un"
            "email" => array:1 [
              0 => "cgallego&#64;hsll&#46;es"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "M&#46;"
            "apellidos" => "Arrizabalaga Asenjo"
          ]
          2 => array:2 [
            "nombre" => "J&#46;"
            "apellidos" => "Gonz&#225;lez-Moreno"
          ]
          3 => array:2 [
            "nombre" => "I&#46;"
            "apellidos" => "Ferullo"
          ]
          4 => array:2 [
            "nombre" => "A&#46;"
            "apellidos" => "Teslev"
          ]
          5 => array:2 [
            "nombre" => "V&#46;"
            "apellidos" => "Fern&#225;ndez-Vaca"
          ]
          6 => array:2 [
            "nombre" => "A&#46;"
            "apellidos" => "Payeras Cifre"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Medicina Interna&#44; Hospital Son Ll&#224;tzer&#44; Palma de Mallorca&#44; Spain"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "S&#237;filis en hombres que tienen sexo con hombres&#58; una alarma para la detecci&#243;n de infecci&#243;n por VIH"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Syphilis is a universally distributed disease caused by the spirochete <span class="elsevierStyleItalic">Treponema pallidum</span> subspecies <span class="elsevierStyleItalic">pallidum</span> that has important health&#44; social&#44; and economic repercussions&#46; The number of syphilis cases has been increasing in various European and North American cities since the second half of the 20th century&#46;<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">1&#44;2</span></a> Men who have sex with men &#40;MSM&#41; account for much of this increase&#46;<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">3&#8211;6</span></a> A worryingly high proportion of MSM with syphilis are also infected with the human immunodeficiency virus &#40;HIV&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">3&#44;5&#44;7</span></a> The reasons for this change of trend appear to be complex<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">7</span></a> but include migratory movements&#44; contacts between different population groups&#44; changes in risky behaviors&#44; the use of various drugs&#44; and the decrease in safe sex practices in MSM that coincided with the introduction of antiretroviral &#40;ARV&#41; therapy&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">8</span></a> In 2011&#44; 3522 cases of syphilis were reported in Spain&#44; and the incidence of the disease was 7&#46;6 cases per 100&#160;000 inhabitants&#46; The annual incidence of syphilis grew considerably between 2005 and 2011&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">2</span></a> The autonomous communities that reported the highest rates were Madrid &#40;14&#46;3 cases per 100&#160;000 inhabitants&#41;&#44; the Balearic Islands &#40;11&#46;6 cases per 100&#160;000 inhabitants&#41;&#44; and Asturias &#40;10&#46;9 cases per 100&#160;000 inhabitants&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">2</span></a> The aim of our study was to describe the clinical and epidemiological characteristics of syphilis in MSM within the area of influence of our hospital and to compare these characteristics with those of heterosexual men&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Materials and Methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Design</span><p id="par0010" class="elsevierStylePara elsevierViewall">We performed a retrospective analysis of the syphilis serologies carried out between January 2005 and June 2013 at Hospital Son Ll&#224;tzer&#44; a 350-bed hospital in Palma de Mallorca that serves a population of 225&#160;000 inhabitants&#46; The study was approved by the hospital&#39;s research committee&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Patients</span><p id="par0015" class="elsevierStylePara elsevierViewall">All cases of syphilis confirmed serologically in MSM during the study period were included regardless of the reason for which the serology was ordered &#40;screening of asymptomatic patients or appearance of clinical symptoms&#41;&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Methods</span><p id="par0020" class="elsevierStylePara elsevierViewall">At our hospital&#44; the first step in syphilis screening is a treponemal test that detects antitreponemal antibodies by means of a chemiluminescence immunoassay &#40;CLIA&#41;&#44; a test described as having 100&#37; sensitivity and 99&#46;8&#37; specificity&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">9</span></a> In the event of a positive CLIA result&#44; a rapid plasma reagin test &#40;RPR&#41; and a second treponemal test&#8212;<span class="elsevierStyleItalic">Treponema pallidum</span> hemaglutination assay &#40;TPHA&#41;&#8212;are then carried out to confirm the result of the first test or detect a false positive&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Study Variables</span><p id="par0025" class="elsevierStylePara elsevierViewall">The following clinical and serologic data were retrospectively collected from the patients&#8217; electronic medical records&#58; age&#44; sexual orientation&#44; smoking and alcohol intake&#44; HIV serology&#44; CD4 cell count&#44; use of ARV therapy&#44; previous diagnosis of syphilis&#44; other sexually transmitted infections &#40;STIs&#41;&#44; country of origin&#44; syphilis status&#44; and treatment received&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Definitions</span><p id="par0030" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">a&#41;</span><p id="par0035" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Primary syphilis</span>&#58; Clinical picture &#40;hard chancre accompanied or not by bilateral lymph node enlargement&#41; consistent with positive results in treponemal tests &#40;CLIA&#44; TPHA&#41;&#44; regardless of nontreponemal test results&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">b&#41;</span><p id="par0040" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Secondary syphilis</span>&#58; Clinical picture consistent with positive results in treponemal &#40;CLIA&#44; TPHA&#41; and nontreponemal &#40;RPR&#41; tests&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">c&#41;</span><p id="par0045" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Early latent syphilis</span>&#58; Positive results in treponemal &#40;CLIA&#44; TPHA&#41; and nontreponemal &#40;RPR&#41; tests without clinical symptoms&#44; with evidence of a picture consistent with primary syphilis or seroconversion &#62;&#160;1 year before diagnosis&#46;</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">d&#41;</span><p id="par0050" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Late latent syphilis or syphilis of unknown duration</span>&#58; Positive results in treponemal &#40;CLIA&#44; TPHA&#41; tests&#44; regardless of nontreponemal test results&#44; without clinical symptoms or prior treatment&#44; and with evidence of syphilis infection &#62;&#160;1 year earlier or unknown duration of infection&#46;</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">e&#41;</span><p id="par0055" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Neurosyphilis</span>&#58; Clinical suspicion of syphilis affecting the central nervous system and positive serology in the cerebrospinal fluid in either nontreponemal &#40;venereal disease research laboratory&#41; or treponemal &#40;fluorescent treponemal antibody absorption&#41; tests&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">8</span></a></p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">f&#41;</span><p id="par0060" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Serologic cure</span>&#58; 2-dilution RDR titer decrease in patients with positive nontreponemal test results&#46;</p></li><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">g&#41;</span><p id="par0065" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Reinfection</span>&#58; Serologic titer increase following a correct serologic response&#46;</p></li><li class="elsevierStyleListItem" id="lsti0040"><span class="elsevierStyleLabel">h&#41;</span><p id="par0070" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Treatment failure</span>&#58; Decrease of &#60;&#160;4<span class="elsevierStyleHsp" style=""></span>titers at 6<span class="elsevierStyleHsp" style=""></span>months&#46;</p></li></ul></p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Statistics</span><p id="par0075" class="elsevierStylePara elsevierViewall">In the descriptive analysis&#44; we determined medians and ranges for continuous variables and frequencies and percentages for categorical variables&#46; Quantitative variables were compared using the <span class="elsevierStyleItalic">t</span> test&#46; For qualitative variables&#44; the &#967;<span class="elsevierStyleSup">2</span> test was used when the necessary applicability criteria were met&#46; Statistical significance was set at a value of <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;05&#46; For risk estimation&#44; odds ratios were calculated with a 95&#37; CI&#46; The statistical analysis was carried out using the SPSS statistical package &#40;version 18&#41; and Epidat &#40;version 3&#46;1&#41;&#46;</p></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Results</span><p id="par0080" class="elsevierStylePara elsevierViewall">During the study period&#44; 323 cases of syphilis were diagnosed&#46; In 161 cases &#40;49&#46;8&#37;&#41;&#44; the patient&#39;s sexual orientation was included in the clinical record&#58; 55 patients &#40;34&#46;2&#37;&#41; were MSM and 106 &#40;65&#46;8&#37;&#41; were heterosexual&#46; Of the heterosexual patients&#44; 39 &#40;36&#46;8&#37;&#41; were men and 67 &#40;63&#46;2&#37;&#41; were women&#46; Although there was some interannual variability&#44; the number of syphilis cases diagnosed per year was relatively stable&#46; The trend over time in the diagnosis of syphilis cases in MSM remained stable throughout the study period&#46;</p><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Results in Men Who Have Sex With Men</span><p id="par0085" class="elsevierStylePara elsevierViewall">In MSM patients&#44; the median age was 37&#46;5 years &#40;range&#44; 20-80<span class="elsevierStyleHsp" style=""></span>y&#41;&#46; Other epidemiologic variables are shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; Serologic status for HIV was known in all cases&#46; Forty-one patients &#40;74&#46;5&#37;&#41; were HIV-positive&#46; Of the HIV-positive patients&#44; 12 &#40;29&#46;3&#37;&#41; were receiving ARV therapy&#46; In the remaining 29 patients&#44; HIV and syphilis were diagnosed simultaneously&#46; In HIV-infected patients&#44; the median CD4 count was 456<span class="elsevierStyleHsp" style=""></span>cells&#47;&#956;l &#40;range&#44; 29-979<span class="elsevierStyleHsp" style=""></span>cells&#47;&#956;l&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">Syphilis was diagnosed clinically in 27 cases &#40;49&#46;1&#37;&#41; and by screening in 28 asymptomatic patients &#40;50&#46;9&#37;&#41;&#46; Evidence of previous syphilis infection was present in 13 cases &#40;23&#46;6&#37;&#41;&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">The most frequent clinical form of the disease was late latent syphilis or syphilis of unknown duration&#44; which was diagnosed in 23 cases &#40;41&#46;8&#37;&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46; A total of 50 patients underwent treatment&#44; 48 &#40;96&#46;0&#37;&#41; with penicillin and 2 &#40;4&#46;0&#37;&#41; with doxycycline&#44; although the reason for the use of the latter drug was not indicated in the clinical records&#46; No treatment was carried out in 5 patients with late latent syphilis&#44; and the reason was not indicated in the clinical records&#46; Clinical and serologic cure was achieved in 30 patients &#40;60&#46;0&#37;&#41;&#46; Cure was not achieved in 1 case &#40;2&#46;0&#37;&#41; because the patient died for another reason&#44; and the remaining 19 patients &#40;34&#46;5&#37;&#41; were lost to follow-up&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Results in Heterosexual Men</span><p id="par0100" class="elsevierStylePara elsevierViewall">In heterosexual men&#44; the median age was 47&#46;3<span class="elsevierStyleHsp" style=""></span>years &#40;range&#44; 18-85 y&#41;&#44; significantly higher than in MSM &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;0053&#41;&#46; Other epidemiologic variables are shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; As in MSM&#44; serologic status was known for all patients in this subgroup&#46; Twelve heterosexual patients &#40;30&#46;8&#37;&#41; were HIV-positive&#46; In HIV-infected patients&#44; the median CD4 count was 422<span class="elsevierStyleHsp" style=""></span>cells&#47;&#956;l &#40;range&#44; 94-1030<span class="elsevierStyleHsp" style=""></span>cells&#47;&#956;l&#41;&#46; Syphilis was diagnosed clinically in 12 cases &#40;30&#46;8&#37;&#41; and by screening in 27 asymptomatic patients &#40;69&#46;2&#37;&#41;&#46; As in MSM&#44; the most frequent clinical form of syphilis in heterosexual men was late latent syphilis or syphilis of unknown duration&#44; which was diagnosed in 27 cases &#40;69&#46;2&#37;&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46; Seven heterosexual men &#40;17&#46;9&#37;&#41; were lost to follow-up&#8212;fewer than in the MSM group&#44; although the difference was not statistically significant&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Comparative analysis revealed that HIV coinfection was more common in MSM than in heterosexual men&#44; as shown in <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#46; Although there were no statistically significant differences between the clinical diagnoses and the screening diagnoses &#40;even when each clinical form is analyzed separately&#41;&#44; the symptomatic forms of the disease were more common in MSM&#46; The median CD4 count was higher in MSM patients than in HIV-infected heterosexual patients&#8212;in whom it was 422<span class="elsevierStyleHsp" style=""></span>cells&#47;&#956;l &#40;range&#44; 23-103<span class="elsevierStyleHsp" style=""></span>cells&#47;&#956;l&#41;&#8212;although the difference was not statistically significant&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0110" class="elsevierStylePara elsevierViewall">Comparative analysis of HIV-infected men &#40;either MSM or heterosexual&#41; and non-HIV-infected men showed only that syphilis reinfection was more common in the former group &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>&#41;&#46; Finally&#44; we observed a trend toward a greater prevalence of symptomatic cases in HIV-infected patients&#44; although no statistically significant differences were found&#44; even when patients were analyzed by syphilis status&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia></span></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Discussion</span><p id="par0115" class="elsevierStylePara elsevierViewall">Our study allowed us to obtain an overview of the clinical and epidemiologic characteristics of syphilis infection in the MSM population in our area&#46; The high percentage of patients coinfected with HIV in our case series was noteworthy&#44; as was the number of reinfections&#46; The clinical form diagnosed most frequently was late latent syphilis or syphilis of unknown duration&#44; as would be expected in a population in which screening accounts for more than half of diagnoses&#46; The high percentage of patients lost to follow-up was notable&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">In recent years&#44; the incidence of syphilis has increased worldwide<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">1&#44;10</span></a> and also in Spain<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">2</span></a> and the Balearic Islands specifically&#46; This increase in the incidence of syphilis has occurred mainly in HIV-infected people&#44; particularly MSM&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">7</span></a> Although our study found a stable trend in diagnoses of syphilis in MSM&#44; it must be noted that the study period&#8212;from 2005&#44; when the CLIA method of syphilis screening became available&#44; until 2013&#8212;was very short&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Most of the worldwide increase in the incidence of syphilis occurred in the late 1990s and the first years of the 21st century&#44; with a linear increase continuing until the present day&#46; This increase has coincided with the introduction of ARV therapy&#8212;which allows better control of HIV infection&#8212;and a consequent change in risky behaviors brought about by a false sense of protection against potential HIV-related clinical complications&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">11</span></a> In a series of 26 patients in Spain&#44; inconsistent condom use and a larger number of sexual partners were found to be risk factors for syphilis in MSM&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">12</span></a></p><p id="par0130" class="elsevierStylePara elsevierViewall">Because our study was conducted at a hospital&#8212;as opposed to a center dedicated exclusively to treating STIs&#8212;we have no specific data on risk behaviors&#46; Approximately half of the MSM patients in our series were diagnosed clinically&#8212;a notable finding&#44; as one would expect more cases to be diagnosed by screening in this high-risk group&#46; This finding can probably be explained by the fact that the patients included in the analysis were evaluated in a hospital setting as opposed to a primary care center or a center dedicated exclusively to STIs&#44; where screening would be the predominant diagnostic method&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">When the MSM population was compared with the population of heterosexual men&#44; the symptomatic forms of syphilis&#8212;primary&#44; secondary&#44; and neurosyphilis&#8212;were found to be more frequent in MSM&#44; although the differences were not statistically significant&#46; HIV coinfection was also more common in MSM&#46; This finding is consistent with the previous literature&#44;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">13</span></a> although&#44; notably&#44; the percentage of MSM coinfected with HIV was much larger than in other series&#44;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">4&#44;5&#44;12</span></a> including a Spanish multicenter epidemiologic study of more than 500 MSM with syphilis&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">13</span></a> The high percentage of HIV coinfection in our case series&#8212;even higher than that found in a Spanish epidemiologic study of hospitalizations for syphilis<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">3</span></a>&#8212;was not limited exclusively to MSM&#46; Because syphilis and HIV share mechanisms of transmission&#44; diagnosis of both infections is not uncommon&#44; especially in groups like MSM that engage in risky sexual practices&#46; In addition&#44; syphilis can enhance transmission of HIV&#44; mainly through mucosal abnormalities caused by genital ulcers&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">14</span></a> The association between syphilis and HIV is therefore of great epidemiologic and clinical importance because both infections are associated with high morbidity and mortality and are therefore public health problems&#46;<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">7&#44;8</span></a> HIV infection can also modify the natural course of syphilis infection&#44; and symptomatic infections &#40;secondary syphilis&#44; neurosyphilis&#41; are more common in HIV-infected patients&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">15</span></a> This could explain the larger number of symptomatic syphilis diagnoses in MSM in our study &#40;nearly three quarters of MSM with syphilis were also infected with HIV&#41;&#46; This result contrasts with the findings of other international case series in which the percentage of coinfected patients was smaller&#44;<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">16&#8211;19</span></a> although most of those works were based on studies of population screening&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Remarkably&#44; nearly three quarters of the cases of HIV-syphilis coinfection were diagnosed simultaneously&#44; a much higher percentage than that found in other case series&#46;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">4&#44;18&#44;20</span></a> In these patients&#44; HIV was diagnosed at a relatively early stage &#40;with a median CD4 count of 456&#41;&#44; as in previous studies&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">4</span></a> This finding highlights the importance of proper screening for HIV infection in syphilis-infected MSM&#44; which could allow the viral infection to be diagnosed at an earlier stage&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">The number of patients lost to follow-up in our study was high&#8212;approximately one third of the evaluated population&#8212;but lower than the percentage found in other case series&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">19</span></a></p><p id="par0150" class="elsevierStylePara elsevierViewall">The percentage of MSM patients was lower than that found in other Spanish studies&#44; although the earlier works were based on studies carried out in large cities at centers specialized in STIs&#44; where larger aggregations of this risk group can be found&#46;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">4&#44;5&#44;12</span></a></p><p id="par0155" class="elsevierStylePara elsevierViewall">Our study had several limitations&#46; As a retrospective review based on data from clinical records&#44; it was subject to information bias&#46; Additionally&#44; the number of MSM patients was low&#44; probably because many cases with positive serologies for syphilis were excluded from the analysis &#40;latent and treated syphilis were indistinguishable in the patient records&#41;&#46; In light of the fact that different societies<a class="elsevierStyleCrossRefs" href="#bib0220"><span class="elsevierStyleSup">21&#8211;23</span></a> have different recommendations regarding screening methods&#44; one possible explanation for this&#8212;in addition to the lack of patient follow-up&#8212;could be an erroneous interpretation of serologic profiles&#46; Finally&#44; because sexual orientation was recorded in less than half of the clinical histories&#44; a large number of patients were excluded from the analysis&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">In conclusion&#44; syphilis-HIV coinfection is very common&#44; especially in the MSM population&#46; The presence of syphilis or HIV should alert the physician to the possibility of the other infection&#46; HIV screening in patients with syphilis&#44; especially MSM&#44; would probably lead to more&#44; and earlier&#44; diagnoses of HIV&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Ethical Disclosures</span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Protection of persons and animals</span><p id="par0165" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for the purpose of this study&#46;</p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Confidentiality of data</span><p id="par0170" class="elsevierStylePara elsevierViewall">The authors declare that they followed their hospital&#39;s regulations regarding the publication of patient information&#46;</p></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Right to privacy and informed consent</span><p id="par0175" class="elsevierStylePara elsevierViewall">The authors have obtained the informed consent of the patients and&#47;or subjects referred to in this article&#46; This document is in the possession of the corresponding author&#46;</p></span></span><span id="sec0085" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0145">Conflicts of Interest</span><p id="par0180" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:11 [
        0 => array:3 [
          "identificador" => "xres576320"
          "titulo" => "Abstract"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0005"
              "titulo" => "Objective"
            ]
            1 => array:2 [
              "identificador" => "abst0010"
              "titulo" => "Methods"
            ]
            2 => array:2 [
              "identificador" => "abst0015"
              "titulo" => "Results"
            ]
            3 => array:2 [
              "identificador" => "abst0020"
              "titulo" => "Conclusions"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec592974"
          "titulo" => "Keywords"
        ]
        2 => array:3 [
          "identificador" => "xres576319"
          "titulo" => "Resumen"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0025"
              "titulo" => "Objetivos"
            ]
            1 => array:2 [
              "identificador" => "abst0030"
              "titulo" => "M&#233;todos"
            ]
            2 => array:2 [
              "identificador" => "abst0035"
              "titulo" => "Resultados"
            ]
            3 => array:2 [
              "identificador" => "abst0040"
              "titulo" => "Conclusiones"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec592973"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:3 [
          "identificador" => "sec0010"
          "titulo" => "Materials and Methods"
          "secciones" => array:6 [
            0 => array:2 [
              "identificador" => "sec0015"
              "titulo" => "Design"
            ]
            1 => array:2 [
              "identificador" => "sec0020"
              "titulo" => "Patients"
            ]
            2 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "Methods"
            ]
            3 => array:2 [
              "identificador" => "sec0030"
              "titulo" => "Study Variables"
            ]
            4 => array:2 [
              "identificador" => "sec0035"
              "titulo" => "Definitions"
            ]
            5 => array:2 [
              "identificador" => "sec0040"
              "titulo" => "Statistics"
            ]
          ]
        ]
        6 => array:3 [
          "identificador" => "sec0045"
          "titulo" => "Results"
          "secciones" => array:2 [
            0 => array:2 [
              "identificador" => "sec0050"
              "titulo" => "Results in Men Who Have Sex With Men"
            ]
            1 => array:2 [
              "identificador" => "sec0055"
              "titulo" => "Results in Heterosexual Men"
            ]
          ]
        ]
        7 => array:2 [
          "identificador" => "sec0060"
          "titulo" => "Discussion"
        ]
        8 => array:3 [
          "identificador" => "sec0065"
          "titulo" => "Ethical Disclosures"
          "secciones" => array:3 [
            0 => array:2 [
              "identificador" => "sec0070"
              "titulo" => "Protection of persons and animals"
            ]
            1 => array:2 [
              "identificador" => "sec0075"
              "titulo" => "Confidentiality of data"
            ]
            2 => array:2 [
              "identificador" => "sec0080"
              "titulo" => "Right to privacy and informed consent"
            ]
          ]
        ]
        9 => array:2 [
          "identificador" => "sec0085"
          "titulo" => "Conflicts of Interest"
        ]
        10 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2015-03-09"
    "fechaAceptado" => "2015-05-21"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec592974"
          "palabras" => array:3 [
            0 => "Syphilis"
            1 => "Men who have sex with men"
            2 => "Human immunodeficiency virus"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec592973"
          "palabras" => array:3 [
            0 => "S&#237;filis"
            1 => "Hombres que tienen sexo con hombres"
            2 => "Virus de la inmunodeficiencia humana"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To describe the clinical and epidemiological characteristics of syphilis in men who have sex with men &#40;MSM&#41; in an area of Mallorca&#44; Spain&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We performed a retrospective analysis of syphilis cases in MSM seen at a hospital in Mallorca between January 2005 and June 2013&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Fifty-five cases of syphilis were recorded in MSM during the study period &#40;34&#46;3&#37; of all cases diagnosed&#41;&#44; and 74&#46;5&#37; of these patients had human immunodeficiency virus &#40;HIV&#41; coinfection&#46; The two diseases had been diagnosed simultaneously in 70&#46;7&#37; of this population&#46; Patients with HIV coinfection had a median CD4 count of 456<span class="elsevierStyleHsp" style=""></span>cells&#47;&#956;L &#40;range&#44; 29-979 cells&#47;&#956;L&#41;&#46; Syphilis was diagnosed clinically in 49&#46;1&#37; of cases and by screening in the remaining 50&#46;9&#37;&#46; The most common form of syphilis was late latent or indeterminate syphilis &#40;41&#46;9&#37; of cases&#41;&#46; In the group of men with syphilis&#44; MSM had a higher risk of HIV infection&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">A majority of MSM with syphilis had HIV coinfection&#46; HIV screening is therefore essential in this population and could even result in early diagnosis&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Objective"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Methods"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusions"
          ]
        ]
      ]
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objetivos</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Describir las caracter&#237;sticas clinicoepidemiol&#243;gicas de la s&#237;filis en la poblaci&#243;n de hombres que tienen sexo con hombres en un &#225;rea de Mallorca&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Revisi&#243;n retrospectiva de los casos de s&#237;filis en pacientes hombres que tienen sexo con hombres &#40;HSH&#41; entre enero de 2005 y junio de 2013 en un hospital de Mallorca&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Encontramos 55 casos de s&#237;filis en HSH&#44; el 34&#44;3&#37; de los casos de s&#237;filis del periodo de estudio&#46; El 74&#44;5&#37; ten&#237;an coinfecci&#243;n por el virus de la inmunodeficiencia humana &#40;VIH&#41;&#46; El 70&#44;7&#37; de los diagn&#243;sticos de infecci&#243;n por VIH y s&#237;filis fueron simult&#225;neos&#46; Los pacientes con infecci&#243;n por VIH ten&#237;an una mediana de CD4 de 456 &#40;29-979&#41;&#46; Se diagnosticaron por cl&#237;nica el 49&#44;1&#37; y por cribado el 50&#44;9&#37; de los casos&#46; La s&#237;filis latente tard&#237;a o indeterminada fue la entidad m&#225;s frecuente &#40;41&#44;9&#37;&#41;&#46; Los pacientes HSH ten&#237;an m&#225;s riego de estar infectados por VIH que los varones no HSH&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">La mayor&#237;a de pacientes HSH con s&#237;filis presentan coinfecci&#243;n por el VIH&#44; siendo por lo tanto fundamental el cribado de VIH en estos pacientes&#44; lo que incluso puede permitir un diagn&#243;stico temprano de la misma&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Objetivos"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "M&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusiones"
          ]
        ]
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; G&#225;llego-Lez&#225;un C&#44; Arrizabalaga Asenjo M&#44; Gonz&#225;lez-Moreno J&#44; Ferullo I&#44; Teslev A&#44; Fern&#225;ndez-Vaca V&#44; et al&#46; S&#237;filis en hombres que tienen sexo con hombres&#58; una alarma para la detecci&#243;n de infecci&#243;n por VIH&#46; Actas Dermosifiliogr&#46; 2015&#59;106&#58;740&#8211;745&#46;</p>"
      ]
    ]
    "multimedia" => array:4 [
      0 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Abbreviations&#58; ARV&#44; antiretroviral&#59; HIV&#44; human immunodeficiency virus&#59; MSM&#44; men who have sex with men&#59; STI&#44; sexually transmitted infection&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Variable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">MSM &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>55&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Heterosexual Men &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>39&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Smoking</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">28 &#40;50&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">18 &#40;46&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Alcoholism</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8 &#40;14&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;5&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">HIV infection</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">41 &#40;74&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12 &#40;30&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">HIV infection with ARV therapy</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12 &#40;29&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5 &#40;12&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Other STIs</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8 &#40;14&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;5&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Genital warts&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3 &#40;5&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;5&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Herpes simplex&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3 &#40;5&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Nongonococcal urethritis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;3&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Immigrants</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15 &#40;27&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11 &#40;28&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Previous syphilis</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13 &#40;23&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8 &#40;20&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab940636.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Clinical Characteristics of Male Patients &#40;MSM and Heterosexual Men&#41; With Syphilis&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Abbreviation&#58; MSM&#44; men who have sex with men&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Clinical Form&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">MSM &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>55&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Heterosexual Men &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>39&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Primary syphilis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9 &#40;16&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3 &#40;7&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Secondary syphilis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">14 &#40;25&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6 &#40;15&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Early latent syphilis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4 &#40;7&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;2&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Late latent syphilis or syphilis of unknown duration&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">23 &#40;41&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">27 &#40;69&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Neurosyphilis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5 &#40;9&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;5&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab940639.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Clinical Stage of Syphilis Cases in MSM and Heterosexual Men&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "tbl0015"
        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Abbreviations&#58; HIV&#44; human immunodeficiency virus&#59; MSM&#44; men who have sex with men&#59; NS&#44; not significant&#59; OR&#44; odds ratio&#59; STI&#44; sexually transmitted infection&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">MSM&#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>55&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Heterosexual Men&#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>39&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">P</span> Value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Diagnosis by screening&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">28 &#40;50&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">27 &#40;69&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Clinical diagnosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">27 &#40;49&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12 &#40;30&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Reinfection&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13 &#40;23&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8 &#40;20&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">HIV-infected&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">41 &#40;74&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12 &#40;30&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;&#160;&#46;0001&#59; OR&#44; 6&#46;59 &#40;95&#37; CI&#44; 2&#46;67-16&#46;26&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Other STIs&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8 &#40;14&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;5&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;034&#59; OR&#44; 3&#46;44 &#40;95&#37; CI&#44; 1&#46;07-11&#46;07&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab940638.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Comparative Analysis of Syphilis Cases in MSM and Heterosexual Men&#46;</p>"
        ]
      ]
      3 => array:7 [
        "identificador" => "tbl0020"
        "etiqueta" => "Table 4"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Abbreviations&#58; HIV&#44; human immunodeficiency virus&#59; NS&#44; not significant&#59; OR&#44; odds ratio&#59; STI&#44; sexually transmitted infection&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">HIV-Infected&#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>53&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Non-HIV-Infected&#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>41&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">P</span> Value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Diagnosis by screening&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">33 &#40;62&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">22 &#40;53&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Clinical diagnosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">20 &#40;37&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">19 &#40;46&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Reinfection&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16 &#40;30&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5 &#40;12&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;032&#59; OR&#44; 3&#46;11 &#40;95&#37; CI&#44; 1&#46;06-9&#46;03&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Other STIs&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8 &#40;15&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;4&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab940637.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Comparative Analysis of Syphilis Cases in HIV-Infected Men and Non-HIV-Infected Men&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:23 [
            0 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Centers for Disease Control and Prevention&#46; Sexually Transmitted Disease Surveillance 2012&#46; Atlanta&#58; U&#46;S&#46; Department of Health and Human Services&#59; 2013&#46; <a href="http://www.cdc.gov/std/stats">http&#58;&#47;&#47;www&#46;cdc&#46;gov&#47;std&#47;stats</a>&#46; Accessed November 29&#44; 2014&#46;"
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Centro Nacional de Epidemiolog&#237;a&#46; Instituto de Salud Carlos III&#46; Resultados de la vigilancia epidemiol&#243;gica de las enfermedades transmisibles&#46; Informe anual 2011&#46; Madrid&#44; 2013&#46; <a href="http://www.isciii.es/">http&#58;&#47;&#47;www&#46;isciii&#46;es</a>&#46; Accessed November 28&#44; 2014&#46;"
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidemiology of hospitalizations due to syphilis in large urban areas in Spain between 1997 and 2006"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "L&#46; Garc&#237;a-Garc&#237;a"
                            1 => "M&#46;C&#46; Ariza Meg&#237;a"
                            2 => "A&#46; Alvaro"
                            3 => "A&#46; Gil de Miguel"
                            4 => "R&#46; Gil-Prieto"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Sex Reprod Health&#46;"
                        "fecha" => "2010"
                        "volumen" => "1"
                        "paginaInicial" => "123"
                        "paginaFinal" => "127"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Reemergence of infectious syphilis among homosexual men and HIV coinfection in Barcelona&#44; 2002-2003"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; Vall-Mayans"
                            1 => "M&#46; Casals"
                            2 => "A&#46; Vives"
                            3 => "E&#46; Loureiro"
                            4 => "P&#46; Armengol"
                            5 => "B&#46; Sanz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Med Clin &#40;Barc&#41;&#46;"
                        "fecha" => "2006"
                        "volumen" => "126"
                        "paginaInicial" => "94"
                        "paginaFinal" => "96"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16472482"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increase in syphilis and gonorrhoea among men who have sex with men in Madrid"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "B&#46; Men&#233;ndez"
                            1 => "J&#46; Ballesteros"
                            2 => "P&#46; Clavo"
                            3 => "J&#46; del Romero"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Med Clin &#40;Barc&#41;&#46;"
                        "fecha" => "2005"
                        "volumen" => "125"
                        "paginaInicial" => "756"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16324473"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidemiological study of an epidemic outbreak of syphilis in Palmas de Gran Canaria"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Vilar"
                            1 => "L&#46; Dehesa"
                            2 => "A&#46;J&#46; G&#243;mez-Duaso"
                            3 => "J&#46; Bastida"
                            4 => "P&#46; Rivero"
                            5 => "J&#46; Dom&#237;nguez-Silva"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr&#46;"
                        "fecha" => "2007"
                        "volumen" => "98"
                        "paginaInicial" => "466"
                        "paginaFinal" => "469"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17669300"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Syphilis and HIV infection"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "R&#46; Palacios Mu&#241;oz"
                            1 => "J&#46; de la Fuente Aguado"
                            2 => "J&#46; Murillas Angoiti"
                            3 => "J&#46;M&#46; Nogueira Coito"
                            4 => "J&#46; Santos Gonz&#225;lez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Enferm Infecc Microbiol Clin&#46;"
                        "fecha" => "2006"
                        "volumen" => "24"
                        "numero" => "Suppl 2"
                        "paginaInicial" => "34"
                        "paginaFinal" => "39"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "2014 European Guideline on the Management of Syphilis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Janier"
                            1 => "V&#46; Hegyi"
                            2 => "N&#46; Dupin"
                            3 => "M&#46; Unemo"
                            4 => "G&#46;S&#46; Tiplica"
                            5 => "M&#46; Potocnik"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:2 [
                        "fecha" => "2014"
                        "editorial" => "European Academy of Dermatology and Venereology"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ensayo Immulite 2000 Syphilis screen en cribado de s&#237;filis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Sampedro"
                            1 => "A&#46; Padilla"
                            2 => "L&#46; Aliagac"
                            3 => "J&#46; S&#225;nchez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Enferm Infecc Microbiol Clin&#46;"
                        "fecha" => "2011"
                        "volumen" => "2"
                        "paginaInicial" => "156"
                        "paginaFinal" => "161"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence of HIV and syphilis infection among men who have sex with men in China&#58; A meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "Y&#46; Zhou"
                            1 => "D&#46; Li"
                            2 => "D&#46; Lu"
                            3 => "Y&#46; Ruan"
                            4 => "X&#46; Qi"
                            5 => "G&#46; Gao"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1155/2014/620431"
                      "Revista" => array:5 [
                        "tituloSerie" => "Biomed Res Int&#46;"
                        "fecha" => "2014"
                        "volumen" => "2014"
                        "paginaInicial" => "620431"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24868533"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Syphilis control &#8212;a continuing challenge"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "E&#46;W&#46;JIII Hook"
                            1 => "R&#46;W&#46; Peeling"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMp048126"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2004"
                        "volumen" => "351"
                        "paginaInicial" => "122"
                        "paginaFinal" => "124"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15247352"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Condom use and number of sexual partners among male syphilis patients who report having sex with men"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "B&#46; Repiso"
                            1 => "M&#46; Frieyro"
                            2 => "F&#46; Rivas-Ruiz"
                            3 => "M&#46; de Troya"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr&#46;"
                        "fecha" => "2010"
                        "volumen" => "101"
                        "paginaInicial" => "847"
                        "paginaFinal" => "852"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21159260"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence of HIV and syphilis infection among high school and college student MSM in China&#58; A systematic review and meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Y&#46; Li"
                            1 => "J&#46; Xu"
                            2 => "K&#46;H&#46; Reilly"
                            3 => "J&#46; Zhang"
                            4 => "H&#46; Wei"
                            5 => "Y&#46; Jiang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "PLoSOne&#46;"
                        "fecha" => "2013"
                        "volumen" => "8"
                        "paginaInicial" => "e69137"
                        "itemHostRev" => array:3 [
                          "pii" => "S0140673612602359"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Syphilis and HIV&#58; A dangerous combination"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "W&#46;A&#46; Lynn"
                            1 => "S&#46; Lightman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S1473-3099(04)01061-8"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet Infect Dis&#46;"
                        "fecha" => "2004"
                        "volumen" => "4"
                        "paginaInicial" => "456"
                        "paginaFinal" => "466"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15219556"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of HIV infection on the course of syphilis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "G&#46; Pialoux"
                            1 => "S&#46; Vimont"
                            2 => "A&#46; Moulignier"
                            3 => "M&#46; Buteux"
                            4 => "B&#46; Abraham"
                            5 => "P&#46; Bonnard"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "AIDS Rev&#46;"
                        "fecha" => "2008"
                        "volumen" => "10"
                        "paginaInicial" => "85"
                        "paginaFinal" => "92"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18615119"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "HIV&#44; syphilis and sexual risk behaviours among men who have sex with men in Agadir and Marrakesh&#44; Morocco"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46;G&#46; Johnston"
                            1 => "K&#46; Alami"
                            2 => "M&#46;H&#46; el Rhilani"
                            3 => "M&#46; Karkouri"
                            4 => "O&#46; Mellouk"
                            5 => "A&#46; Abadie"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Sex Transm Infect&#46;"
                        "fecha" => "2013"
                        "volumen" => "89"
                        "numero" => "Suppl 3"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "HIV-1&#44; HBV&#44; HCV&#44; HTLV HPV-16&#47;18&#44; and <span class="elsevierStyleItalic">Treponema pallidum</span> infections in a sample of Brazilian men who have sex with men"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46;C&#46; Soares"
                            1 => "I&#46; Georg"
                            2 => "E&#46; Lampe"
                            3 => "L&#46; Lewis"
                            4 => "M&#46;G&#46; Morgado"
                            5 => "A&#46;F&#46; Nicol"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1371/journal.pone.0102676"
                      "Revista" => array:5 [
                        "tituloSerie" => "PLoS One&#46;"
                        "fecha" => "2014"
                        "volumen" => "9"
                        "paginaInicial" => "e102676"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25083768"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0205"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "High risk for HIV following syphilis diagnosis among men in Florida&#44; 2000-2011"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "T&#46;A&#46; Peterman"
                            1 => "D&#46;R&#46; Newman"
                            2 => "L&#46; Maddox"
                            3 => "K&#46; Schmitt"
                            4 => "S&#46; Shiver"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Public Health Rep&#46;"
                        "fecha" => "2014"
                        "volumen" => "129"
                        "paginaInicial" => "164"
                        "paginaFinal" => "169"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24587551"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Characteristics and risk of syphilis diagnosis among HIV-infected male cohort&#58; A population based study in Houston&#44; Texas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "B&#46; Yang"
                            1 => "C&#46;J&#46; Hallmark"
                            2 => "J&#46;S&#46; Huang"
                            3 => "M&#46;L&#46; Wolverton"
                            4 => "M&#46; McNeese-Ward"
                            5 => "R&#46;R&#46; Arafat"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/OLQ.0000000000000056"
                      "Revista" => array:6 [
                        "tituloSerie" => "Sex Transm Dis&#46;"
                        "fecha" => "2013"
                        "volumen" => "40"
                        "paginaInicial" => "957"
                        "paginaFinal" => "963"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24220358"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "HIV&#47;STI co-infection among men who have sex with men in Spain"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "STI Study Group and EPI-VIH Group"
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Diaz"
                            1 => "M&#46;L&#46; Junquera"
                            2 => "V&#46; Esteban"
                            3 => "B&#46; Mart&#237;nez"
                            4 => "I&#46; Pueyo"
                            5 => "J&#46; Suarez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "Euro Surveill"
                        "fecha" => "2009"
                        "paginaInicial" => "14"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0220"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Current standards for diagnosis and treatment of syphilis&#58; Selection of some practical issues&#44; based on the European &#40;IUSTI&#41; and U&#46;S&#46; &#40;CDC&#41; guidelines"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46; Pastuszczak"
                            1 => "A&#46; Wojas-Pelc"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.5114/pdia.2013.37029"
                      "Revista" => array:6 [
                        "tituloSerie" => "Postepy Dermatol Alergol&#46;"
                        "fecha" => "2013"
                        "volumen" => "30"
                        "paginaInicial" => "203"
                        "paginaFinal" => "210"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24278076"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "IUSTI&#58; IUST 2008 European guidelines on the management of syphilis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "P&#46; French"
                            1 => "M&#46; Gomberg"
                            2 => "M&#46; Janier"
                            3 => "B&#46; Schmidt"
                            4 => "P&#46; van VoorstVader"
                            5 => "H&#46; Young"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1258/ijsa.2008.008510"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J STD AIDS"
                        "fecha" => "2009"
                        "volumen" => "20"
                        "paginaInicial" => "300"
                        "paginaFinal" => "309"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19386965"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Centers for Disease Control and Prevention &#40;CDC&#41; Sexually transmitted diseases treatment guidelines&#44; 2010"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "K&#46;A&#46; Workowski"
                            1 => "S&#46; Berman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "MMWR Recomm Rep&#46;"
                        "fecha" => "2010"
                        "volumen" => "59"
                        "paginaInicial" => "1"
                        "paginaFinal" => "110"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21160459"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010600000009/v1_201511040157/S1578219015002383/v1_201511040157/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6155"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Original Articles"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010600000009/v1_201511040157/S1578219015002383/v1_201511040157/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015002383?idApp=UINPBA000044"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Original
Syphilis in Men Who Have Sex With Men: A Warning Sign for HIV Infection
Sífilis en hombres que tienen sexo con hombres: una alarma para la detección de infección por VIH
C. Gállego-Lezáun
Corresponding author
cgallego@hsll.es

Corresponding author.
, M. Arrizabalaga Asenjo, J. González-Moreno, I. Ferullo, A. Teslev, V. Fernández-Vaca, A. Payeras Cifre
Medicina Interna, Hospital Son Llàtzer, Palma de Mallorca, Spain
Read
5852
Times
was read the article
2290
Total PDF
3562
Total HTML
Share statistics
 array:24 [
  "pii" => "S1578219015002383"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2015.09.003"
  "estado" => "S300"
  "fechaPublicacion" => "2015-11-01"
  "aid" => "1206"
  "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
  "copyrightAnyo" => "2015"
  "documento" => "article"
  "crossmark" => 1
  "subdocumento" => "fla"
  "cita" => "Actas Dermosifiliogr. 2015;106:740-5"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 836
    "formatos" => array:3 [
      "EPUB" => 44
      "HTML" => 441
      "PDF" => 351
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0001731015002756"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2015.05.010"
      "estado" => "S300"
      "fechaPublicacion" => "2015-11-01"
      "aid" => "1206"
      "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
      "documento" => "article"
      "crossmark" => 1
      "subdocumento" => "fla"
      "cita" => "Actas Dermosifiliogr. 2015;106:740-5"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 1028
        "formatos" => array:3 [
          "EPUB" => 2
          "HTML" => 255
          "PDF" => 771
        ]
      ]
      "es" => array:12 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Original</span>"
        "titulo" => "S&#237;filis en hombres que tienen sexo con hombres&#58; una alarma para la detecci&#243;n de infecci&#243;n por VIH"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "tieneResumen" => array:2 [
          0 => "es"
          1 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "740"
            "paginaFinal" => "745"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Syphilis in Men Who Have Sex With Men&#58; A Warning Sign for HIV Infection"
          ]
        ]
        "contieneResumen" => array:2 [
          "es" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "C&#46; G&#225;llego-Lez&#225;un, M&#46; Arrizabalaga Asenjo, J&#46; Gonz&#225;lez-Moreno, I&#46; Ferullo, A&#46; Teslev, V&#46; Fern&#225;ndez-Vaca, A&#46; Payeras Cifre"
            "autores" => array:7 [
              0 => array:2 [
                "nombre" => "C&#46;"
                "apellidos" => "G&#225;llego-Lez&#225;un"
              ]
              1 => array:2 [
                "nombre" => "M&#46;"
                "apellidos" => "Arrizabalaga Asenjo"
              ]
              2 => array:2 [
                "nombre" => "J&#46;"
                "apellidos" => "Gonz&#225;lez-Moreno"
              ]
              3 => array:2 [
                "nombre" => "I&#46;"
                "apellidos" => "Ferullo"
              ]
              4 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Teslev"
              ]
              5 => array:2 [
                "nombre" => "V&#46;"
                "apellidos" => "Fern&#225;ndez-Vaca"
              ]
              6 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Payeras Cifre"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219015002383"
          "doi" => "10.1016/j.adengl.2015.09.003"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015002383?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015002756?idApp=UINPBA000044"
      "url" => "/00017310/0000010600000009/v1_201511040159/S0001731015002756/v1_201511040159/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1578219015002425"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2015.09.007"
    "estado" => "S300"
    "fechaPublicacion" => "2015-11-01"
    "aid" => "1205"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "fla"
    "cita" => "Actas Dermosifiliogr. 2015;106:746-52"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1028
      "formatos" => array:3 [
        "EPUB" => 55
        "HTML" => 720
        "PDF" => 253
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">ORIGINAL</span>"
      "titulo" => "Cross-Cultural Adaptation of the Urticaria Control Test From German to Castilian Spanish"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "746"
          "paginaFinal" => "752"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Adaptaci&#243;n transcultural del cuestionario <span class="elsevierStyleItalic">Urticaria Control Test</span> del alem&#225;n al castellano"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1944
              "Ancho" => 2452
              "Tamanyo" => 418893
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Flow chart of work required for the cross-cultural adaptation of the Urticaria Control Test &#40;UCT&#41; to Castillian Spanish for use in Spain&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "I&#46; Garc&#237;a-D&#237;ez, L&#46; Curto-Barredo, K&#46; Weller, R&#46;M&#46; Pujol, M&#46; Maurer, A&#46;M&#46; Gim&#233;nez-Arnau"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "I&#46;"
              "apellidos" => "Garc&#237;a-D&#237;ez"
            ]
            1 => array:2 [
              "nombre" => "L&#46;"
              "apellidos" => "Curto-Barredo"
            ]
            2 => array:2 [
              "nombre" => "K&#46;"
              "apellidos" => "Weller"
            ]
            3 => array:2 [
              "nombre" => "R&#46;M&#46;"
              "apellidos" => "Pujol"
            ]
            4 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Maurer"
            ]
            5 => array:2 [
              "nombre" => "A&#46;M&#46;"
              "apellidos" => "Gim&#233;nez-Arnau"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731015002744"
        "doi" => "10.1016/j.ad.2015.05.009"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015002744?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015002425?idApp=UINPBA000044"
    "url" => "/15782190/0000010600000009/v1_201511040157/S1578219015002425/v1_201511040157/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1578219015002413"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2015.09.006"
    "estado" => "S300"
    "fechaPublicacion" => "2015-11-01"
    "aid" => "1215"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "fla"
    "cita" => "Actas Dermosifiliogr. 2015;106:733-9"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1135
      "formatos" => array:3 [
        "EPUB" => 59
        "HTML" => 728
        "PDF" => 348
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>"
      "titulo" => "Otologic Manifestations of Autosomal Recessive Congenital Ichthyosis in Children"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "733"
          "paginaFinal" => "739"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Manifestaciones otol&#243;gicas en los ni&#241;os con ictiosis cong&#233;nitas autos&#243;micas recesivas"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1462
              "Ancho" => 3001
              "Tamanyo" => 591377
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Case 4&#46; A&#44; Collodion baby phenotype at 24<span class="elsevierStyleHsp" style=""></span>hours old&#46; B&#44; Marked ectropion at 3 weeks of age&#46; C&#44; Lamellar ichthyosis phenotype at 4 years of age&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "A&#46; Mart&#237;n-Santiago, M&#46; Rodr&#237;guez-Pascual, N&#46; Kn&#246;pfel, &#193;&#46; Hern&#225;ndez-Mart&#237;n"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Mart&#237;n-Santiago"
            ]
            1 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Rodr&#237;guez-Pascual"
            ]
            2 => array:2 [
              "nombre" => "N&#46;"
              "apellidos" => "Kn&#246;pfel"
            ]
            3 => array:2 [
              "nombre" => "&#193;&#46;"
              "apellidos" => "Hern&#225;ndez-Mart&#237;n"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731015002872"
        "doi" => "10.1016/j.ad.2015.06.003"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015002872?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015002413?idApp=UINPBA000044"
    "url" => "/15782190/0000010600000009/v1_201511040157/S1578219015002413/v1_201511040157/en/main.assets"
  ]
  "en" => array:19 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original</span>"
    "titulo" => "Syphilis in Men Who Have Sex With Men&#58; A Warning Sign for HIV Infection"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "740"
        "paginaFinal" => "745"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "C&#46; G&#225;llego-Lez&#225;un, M&#46; Arrizabalaga Asenjo, J&#46; Gonz&#225;lez-Moreno, I&#46; Ferullo, A&#46; Teslev, V&#46; Fern&#225;ndez-Vaca, A&#46; Payeras Cifre"
        "autores" => array:7 [
          0 => array:4 [
            "nombre" => "C&#46;"
            "apellidos" => "G&#225;llego-Lez&#225;un"
            "email" => array:1 [
              0 => "cgallego&#64;hsll&#46;es"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "M&#46;"
            "apellidos" => "Arrizabalaga Asenjo"
          ]
          2 => array:2 [
            "nombre" => "J&#46;"
            "apellidos" => "Gonz&#225;lez-Moreno"
          ]
          3 => array:2 [
            "nombre" => "I&#46;"
            "apellidos" => "Ferullo"
          ]
          4 => array:2 [
            "nombre" => "A&#46;"
            "apellidos" => "Teslev"
          ]
          5 => array:2 [
            "nombre" => "V&#46;"
            "apellidos" => "Fern&#225;ndez-Vaca"
          ]
          6 => array:2 [
            "nombre" => "A&#46;"
            "apellidos" => "Payeras Cifre"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Medicina Interna&#44; Hospital Son Ll&#224;tzer&#44; Palma de Mallorca&#44; Spain"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "S&#237;filis en hombres que tienen sexo con hombres&#58; una alarma para la detecci&#243;n de infecci&#243;n por VIH"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Syphilis is a universally distributed disease caused by the spirochete <span class="elsevierStyleItalic">Treponema pallidum</span> subspecies <span class="elsevierStyleItalic">pallidum</span> that has important health&#44; social&#44; and economic repercussions&#46; The number of syphilis cases has been increasing in various European and North American cities since the second half of the 20th century&#46;<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">1&#44;2</span></a> Men who have sex with men &#40;MSM&#41; account for much of this increase&#46;<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">3&#8211;6</span></a> A worryingly high proportion of MSM with syphilis are also infected with the human immunodeficiency virus &#40;HIV&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">3&#44;5&#44;7</span></a> The reasons for this change of trend appear to be complex<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">7</span></a> but include migratory movements&#44; contacts between different population groups&#44; changes in risky behaviors&#44; the use of various drugs&#44; and the decrease in safe sex practices in MSM that coincided with the introduction of antiretroviral &#40;ARV&#41; therapy&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">8</span></a> In 2011&#44; 3522 cases of syphilis were reported in Spain&#44; and the incidence of the disease was 7&#46;6 cases per 100&#160;000 inhabitants&#46; The annual incidence of syphilis grew considerably between 2005 and 2011&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">2</span></a> The autonomous communities that reported the highest rates were Madrid &#40;14&#46;3 cases per 100&#160;000 inhabitants&#41;&#44; the Balearic Islands &#40;11&#46;6 cases per 100&#160;000 inhabitants&#41;&#44; and Asturias &#40;10&#46;9 cases per 100&#160;000 inhabitants&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">2</span></a> The aim of our study was to describe the clinical and epidemiological characteristics of syphilis in MSM within the area of influence of our hospital and to compare these characteristics with those of heterosexual men&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Materials and Methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Design</span><p id="par0010" class="elsevierStylePara elsevierViewall">We performed a retrospective analysis of the syphilis serologies carried out between January 2005 and June 2013 at Hospital Son Ll&#224;tzer&#44; a 350-bed hospital in Palma de Mallorca that serves a population of 225&#160;000 inhabitants&#46; The study was approved by the hospital&#39;s research committee&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Patients</span><p id="par0015" class="elsevierStylePara elsevierViewall">All cases of syphilis confirmed serologically in MSM during the study period were included regardless of the reason for which the serology was ordered &#40;screening of asymptomatic patients or appearance of clinical symptoms&#41;&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Methods</span><p id="par0020" class="elsevierStylePara elsevierViewall">At our hospital&#44; the first step in syphilis screening is a treponemal test that detects antitreponemal antibodies by means of a chemiluminescence immunoassay &#40;CLIA&#41;&#44; a test described as having 100&#37; sensitivity and 99&#46;8&#37; specificity&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">9</span></a> In the event of a positive CLIA result&#44; a rapid plasma reagin test &#40;RPR&#41; and a second treponemal test&#8212;<span class="elsevierStyleItalic">Treponema pallidum</span> hemaglutination assay &#40;TPHA&#41;&#8212;are then carried out to confirm the result of the first test or detect a false positive&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Study Variables</span><p id="par0025" class="elsevierStylePara elsevierViewall">The following clinical and serologic data were retrospectively collected from the patients&#8217; electronic medical records&#58; age&#44; sexual orientation&#44; smoking and alcohol intake&#44; HIV serology&#44; CD4 cell count&#44; use of ARV therapy&#44; previous diagnosis of syphilis&#44; other sexually transmitted infections &#40;STIs&#41;&#44; country of origin&#44; syphilis status&#44; and treatment received&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Definitions</span><p id="par0030" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">a&#41;</span><p id="par0035" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Primary syphilis</span>&#58; Clinical picture &#40;hard chancre accompanied or not by bilateral lymph node enlargement&#41; consistent with positive results in treponemal tests &#40;CLIA&#44; TPHA&#41;&#44; regardless of nontreponemal test results&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">b&#41;</span><p id="par0040" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Secondary syphilis</span>&#58; Clinical picture consistent with positive results in treponemal &#40;CLIA&#44; TPHA&#41; and nontreponemal &#40;RPR&#41; tests&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">c&#41;</span><p id="par0045" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Early latent syphilis</span>&#58; Positive results in treponemal &#40;CLIA&#44; TPHA&#41; and nontreponemal &#40;RPR&#41; tests without clinical symptoms&#44; with evidence of a picture consistent with primary syphilis or seroconversion &#62;&#160;1 year before diagnosis&#46;</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">d&#41;</span><p id="par0050" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Late latent syphilis or syphilis of unknown duration</span>&#58; Positive results in treponemal &#40;CLIA&#44; TPHA&#41; tests&#44; regardless of nontreponemal test results&#44; without clinical symptoms or prior treatment&#44; and with evidence of syphilis infection &#62;&#160;1 year earlier or unknown duration of infection&#46;</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">e&#41;</span><p id="par0055" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Neurosyphilis</span>&#58; Clinical suspicion of syphilis affecting the central nervous system and positive serology in the cerebrospinal fluid in either nontreponemal &#40;venereal disease research laboratory&#41; or treponemal &#40;fluorescent treponemal antibody absorption&#41; tests&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">8</span></a></p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">f&#41;</span><p id="par0060" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Serologic cure</span>&#58; 2-dilution RDR titer decrease in patients with positive nontreponemal test results&#46;</p></li><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">g&#41;</span><p id="par0065" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Reinfection</span>&#58; Serologic titer increase following a correct serologic response&#46;</p></li><li class="elsevierStyleListItem" id="lsti0040"><span class="elsevierStyleLabel">h&#41;</span><p id="par0070" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Treatment failure</span>&#58; Decrease of &#60;&#160;4<span class="elsevierStyleHsp" style=""></span>titers at 6<span class="elsevierStyleHsp" style=""></span>months&#46;</p></li></ul></p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Statistics</span><p id="par0075" class="elsevierStylePara elsevierViewall">In the descriptive analysis&#44; we determined medians and ranges for continuous variables and frequencies and percentages for categorical variables&#46; Quantitative variables were compared using the <span class="elsevierStyleItalic">t</span> test&#46; For qualitative variables&#44; the &#967;<span class="elsevierStyleSup">2</span> test was used when the necessary applicability criteria were met&#46; Statistical significance was set at a value of <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;05&#46; For risk estimation&#44; odds ratios were calculated with a 95&#37; CI&#46; The statistical analysis was carried out using the SPSS statistical package &#40;version 18&#41; and Epidat &#40;version 3&#46;1&#41;&#46;</p></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Results</span><p id="par0080" class="elsevierStylePara elsevierViewall">During the study period&#44; 323 cases of syphilis were diagnosed&#46; In 161 cases &#40;49&#46;8&#37;&#41;&#44; the patient&#39;s sexual orientation was included in the clinical record&#58; 55 patients &#40;34&#46;2&#37;&#41; were MSM and 106 &#40;65&#46;8&#37;&#41; were heterosexual&#46; Of the heterosexual patients&#44; 39 &#40;36&#46;8&#37;&#41; were men and 67 &#40;63&#46;2&#37;&#41; were women&#46; Although there was some interannual variability&#44; the number of syphilis cases diagnosed per year was relatively stable&#46; The trend over time in the diagnosis of syphilis cases in MSM remained stable throughout the study period&#46;</p><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Results in Men Who Have Sex With Men</span><p id="par0085" class="elsevierStylePara elsevierViewall">In MSM patients&#44; the median age was 37&#46;5 years &#40;range&#44; 20-80<span class="elsevierStyleHsp" style=""></span>y&#41;&#46; Other epidemiologic variables are shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; Serologic status for HIV was known in all cases&#46; Forty-one patients &#40;74&#46;5&#37;&#41; were HIV-positive&#46; Of the HIV-positive patients&#44; 12 &#40;29&#46;3&#37;&#41; were receiving ARV therapy&#46; In the remaining 29 patients&#44; HIV and syphilis were diagnosed simultaneously&#46; In HIV-infected patients&#44; the median CD4 count was 456<span class="elsevierStyleHsp" style=""></span>cells&#47;&#956;l &#40;range&#44; 29-979<span class="elsevierStyleHsp" style=""></span>cells&#47;&#956;l&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">Syphilis was diagnosed clinically in 27 cases &#40;49&#46;1&#37;&#41; and by screening in 28 asymptomatic patients &#40;50&#46;9&#37;&#41;&#46; Evidence of previous syphilis infection was present in 13 cases &#40;23&#46;6&#37;&#41;&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">The most frequent clinical form of the disease was late latent syphilis or syphilis of unknown duration&#44; which was diagnosed in 23 cases &#40;41&#46;8&#37;&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46; A total of 50 patients underwent treatment&#44; 48 &#40;96&#46;0&#37;&#41; with penicillin and 2 &#40;4&#46;0&#37;&#41; with doxycycline&#44; although the reason for the use of the latter drug was not indicated in the clinical records&#46; No treatment was carried out in 5 patients with late latent syphilis&#44; and the reason was not indicated in the clinical records&#46; Clinical and serologic cure was achieved in 30 patients &#40;60&#46;0&#37;&#41;&#46; Cure was not achieved in 1 case &#40;2&#46;0&#37;&#41; because the patient died for another reason&#44; and the remaining 19 patients &#40;34&#46;5&#37;&#41; were lost to follow-up&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Results in Heterosexual Men</span><p id="par0100" class="elsevierStylePara elsevierViewall">In heterosexual men&#44; the median age was 47&#46;3<span class="elsevierStyleHsp" style=""></span>years &#40;range&#44; 18-85 y&#41;&#44; significantly higher than in MSM &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;0053&#41;&#46; Other epidemiologic variables are shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; As in MSM&#44; serologic status was known for all patients in this subgroup&#46; Twelve heterosexual patients &#40;30&#46;8&#37;&#41; were HIV-positive&#46; In HIV-infected patients&#44; the median CD4 count was 422<span class="elsevierStyleHsp" style=""></span>cells&#47;&#956;l &#40;range&#44; 94-1030<span class="elsevierStyleHsp" style=""></span>cells&#47;&#956;l&#41;&#46; Syphilis was diagnosed clinically in 12 cases &#40;30&#46;8&#37;&#41; and by screening in 27 asymptomatic patients &#40;69&#46;2&#37;&#41;&#46; As in MSM&#44; the most frequent clinical form of syphilis in heterosexual men was late latent syphilis or syphilis of unknown duration&#44; which was diagnosed in 27 cases &#40;69&#46;2&#37;&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46; Seven heterosexual men &#40;17&#46;9&#37;&#41; were lost to follow-up&#8212;fewer than in the MSM group&#44; although the difference was not statistically significant&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Comparative analysis revealed that HIV coinfection was more common in MSM than in heterosexual men&#44; as shown in <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#46; Although there were no statistically significant differences between the clinical diagnoses and the screening diagnoses &#40;even when each clinical form is analyzed separately&#41;&#44; the symptomatic forms of the disease were more common in MSM&#46; The median CD4 count was higher in MSM patients than in HIV-infected heterosexual patients&#8212;in whom it was 422<span class="elsevierStyleHsp" style=""></span>cells&#47;&#956;l &#40;range&#44; 23-103<span class="elsevierStyleHsp" style=""></span>cells&#47;&#956;l&#41;&#8212;although the difference was not statistically significant&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0110" class="elsevierStylePara elsevierViewall">Comparative analysis of HIV-infected men &#40;either MSM or heterosexual&#41; and non-HIV-infected men showed only that syphilis reinfection was more common in the former group &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>&#41;&#46; Finally&#44; we observed a trend toward a greater prevalence of symptomatic cases in HIV-infected patients&#44; although no statistically significant differences were found&#44; even when patients were analyzed by syphilis status&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia></span></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Discussion</span><p id="par0115" class="elsevierStylePara elsevierViewall">Our study allowed us to obtain an overview of the clinical and epidemiologic characteristics of syphilis infection in the MSM population in our area&#46; The high percentage of patients coinfected with HIV in our case series was noteworthy&#44; as was the number of reinfections&#46; The clinical form diagnosed most frequently was late latent syphilis or syphilis of unknown duration&#44; as would be expected in a population in which screening accounts for more than half of diagnoses&#46; The high percentage of patients lost to follow-up was notable&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">In recent years&#44; the incidence of syphilis has increased worldwide<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">1&#44;10</span></a> and also in Spain<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">2</span></a> and the Balearic Islands specifically&#46; This increase in the incidence of syphilis has occurred mainly in HIV-infected people&#44; particularly MSM&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">7</span></a> Although our study found a stable trend in diagnoses of syphilis in MSM&#44; it must be noted that the study period&#8212;from 2005&#44; when the CLIA method of syphilis screening became available&#44; until 2013&#8212;was very short&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Most of the worldwide increase in the incidence of syphilis occurred in the late 1990s and the first years of the 21st century&#44; with a linear increase continuing until the present day&#46; This increase has coincided with the introduction of ARV therapy&#8212;which allows better control of HIV infection&#8212;and a consequent change in risky behaviors brought about by a false sense of protection against potential HIV-related clinical complications&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">11</span></a> In a series of 26 patients in Spain&#44; inconsistent condom use and a larger number of sexual partners were found to be risk factors for syphilis in MSM&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">12</span></a></p><p id="par0130" class="elsevierStylePara elsevierViewall">Because our study was conducted at a hospital&#8212;as opposed to a center dedicated exclusively to treating STIs&#8212;we have no specific data on risk behaviors&#46; Approximately half of the MSM patients in our series were diagnosed clinically&#8212;a notable finding&#44; as one would expect more cases to be diagnosed by screening in this high-risk group&#46; This finding can probably be explained by the fact that the patients included in the analysis were evaluated in a hospital setting as opposed to a primary care center or a center dedicated exclusively to STIs&#44; where screening would be the predominant diagnostic method&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">When the MSM population was compared with the population of heterosexual men&#44; the symptomatic forms of syphilis&#8212;primary&#44; secondary&#44; and neurosyphilis&#8212;were found to be more frequent in MSM&#44; although the differences were not statistically significant&#46; HIV coinfection was also more common in MSM&#46; This finding is consistent with the previous literature&#44;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">13</span></a> although&#44; notably&#44; the percentage of MSM coinfected with HIV was much larger than in other series&#44;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">4&#44;5&#44;12</span></a> including a Spanish multicenter epidemiologic study of more than 500 MSM with syphilis&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">13</span></a> The high percentage of HIV coinfection in our case series&#8212;even higher than that found in a Spanish epidemiologic study of hospitalizations for syphilis<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">3</span></a>&#8212;was not limited exclusively to MSM&#46; Because syphilis and HIV share mechanisms of transmission&#44; diagnosis of both infections is not uncommon&#44; especially in groups like MSM that engage in risky sexual practices&#46; In addition&#44; syphilis can enhance transmission of HIV&#44; mainly through mucosal abnormalities caused by genital ulcers&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">14</span></a> The association between syphilis and HIV is therefore of great epidemiologic and clinical importance because both infections are associated with high morbidity and mortality and are therefore public health problems&#46;<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">7&#44;8</span></a> HIV infection can also modify the natural course of syphilis infection&#44; and symptomatic infections &#40;secondary syphilis&#44; neurosyphilis&#41; are more common in HIV-infected patients&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">15</span></a> This could explain the larger number of symptomatic syphilis diagnoses in MSM in our study &#40;nearly three quarters of MSM with syphilis were also infected with HIV&#41;&#46; This result contrasts with the findings of other international case series in which the percentage of coinfected patients was smaller&#44;<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">16&#8211;19</span></a> although most of those works were based on studies of population screening&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Remarkably&#44; nearly three quarters of the cases of HIV-syphilis coinfection were diagnosed simultaneously&#44; a much higher percentage than that found in other case series&#46;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">4&#44;18&#44;20</span></a> In these patients&#44; HIV was diagnosed at a relatively early stage &#40;with a median CD4 count of 456&#41;&#44; as in previous studies&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">4</span></a> This finding highlights the importance of proper screening for HIV infection in syphilis-infected MSM&#44; which could allow the viral infection to be diagnosed at an earlier stage&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">The number of patients lost to follow-up in our study was high&#8212;approximately one third of the evaluated population&#8212;but lower than the percentage found in other case series&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">19</span></a></p><p id="par0150" class="elsevierStylePara elsevierViewall">The percentage of MSM patients was lower than that found in other Spanish studies&#44; although the earlier works were based on studies carried out in large cities at centers specialized in STIs&#44; where larger aggregations of this risk group can be found&#46;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">4&#44;5&#44;12</span></a></p><p id="par0155" class="elsevierStylePara elsevierViewall">Our study had several limitations&#46; As a retrospective review based on data from clinical records&#44; it was subject to information bias&#46; Additionally&#44; the number of MSM patients was low&#44; probably because many cases with positive serologies for syphilis were excluded from the analysis &#40;latent and treated syphilis were indistinguishable in the patient records&#41;&#46; In light of the fact that different societies<a class="elsevierStyleCrossRefs" href="#bib0220"><span class="elsevierStyleSup">21&#8211;23</span></a> have different recommendations regarding screening methods&#44; one possible explanation for this&#8212;in addition to the lack of patient follow-up&#8212;could be an erroneous interpretation of serologic profiles&#46; Finally&#44; because sexual orientation was recorded in less than half of the clinical histories&#44; a large number of patients were excluded from the analysis&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">In conclusion&#44; syphilis-HIV coinfection is very common&#44; especially in the MSM population&#46; The presence of syphilis or HIV should alert the physician to the possibility of the other infection&#46; HIV screening in patients with syphilis&#44; especially MSM&#44; would probably lead to more&#44; and earlier&#44; diagnoses of HIV&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Ethical Disclosures</span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Protection of persons and animals</span><p id="par0165" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for the purpose of this study&#46;</p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Confidentiality of data</span><p id="par0170" class="elsevierStylePara elsevierViewall">The authors declare that they followed their hospital&#39;s regulations regarding the publication of patient information&#46;</p></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Right to privacy and informed consent</span><p id="par0175" class="elsevierStylePara elsevierViewall">The authors have obtained the informed consent of the patients and&#47;or subjects referred to in this article&#46; This document is in the possession of the corresponding author&#46;</p></span></span><span id="sec0085" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0145">Conflicts of Interest</span><p id="par0180" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:11 [
        0 => array:3 [
          "identificador" => "xres576320"
          "titulo" => "Abstract"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0005"
              "titulo" => "Objective"
            ]
            1 => array:2 [
              "identificador" => "abst0010"
              "titulo" => "Methods"
            ]
            2 => array:2 [
              "identificador" => "abst0015"
              "titulo" => "Results"
            ]
            3 => array:2 [
              "identificador" => "abst0020"
              "titulo" => "Conclusions"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec592974"
          "titulo" => "Keywords"
        ]
        2 => array:3 [
          "identificador" => "xres576319"
          "titulo" => "Resumen"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0025"
              "titulo" => "Objetivos"
            ]
            1 => array:2 [
              "identificador" => "abst0030"
              "titulo" => "M&#233;todos"
            ]
            2 => array:2 [
              "identificador" => "abst0035"
              "titulo" => "Resultados"
            ]
            3 => array:2 [
              "identificador" => "abst0040"
              "titulo" => "Conclusiones"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec592973"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:3 [
          "identificador" => "sec0010"
          "titulo" => "Materials and Methods"
          "secciones" => array:6 [
            0 => array:2 [
              "identificador" => "sec0015"
              "titulo" => "Design"
            ]
            1 => array:2 [
              "identificador" => "sec0020"
              "titulo" => "Patients"
            ]
            2 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "Methods"
            ]
            3 => array:2 [
              "identificador" => "sec0030"
              "titulo" => "Study Variables"
            ]
            4 => array:2 [
              "identificador" => "sec0035"
              "titulo" => "Definitions"
            ]
            5 => array:2 [
              "identificador" => "sec0040"
              "titulo" => "Statistics"
            ]
          ]
        ]
        6 => array:3 [
          "identificador" => "sec0045"
          "titulo" => "Results"
          "secciones" => array:2 [
            0 => array:2 [
              "identificador" => "sec0050"
              "titulo" => "Results in Men Who Have Sex With Men"
            ]
            1 => array:2 [
              "identificador" => "sec0055"
              "titulo" => "Results in Heterosexual Men"
            ]
          ]
        ]
        7 => array:2 [
          "identificador" => "sec0060"
          "titulo" => "Discussion"
        ]
        8 => array:3 [
          "identificador" => "sec0065"
          "titulo" => "Ethical Disclosures"
          "secciones" => array:3 [
            0 => array:2 [
              "identificador" => "sec0070"
              "titulo" => "Protection of persons and animals"
            ]
            1 => array:2 [
              "identificador" => "sec0075"
              "titulo" => "Confidentiality of data"
            ]
            2 => array:2 [
              "identificador" => "sec0080"
              "titulo" => "Right to privacy and informed consent"
            ]
          ]
        ]
        9 => array:2 [
          "identificador" => "sec0085"
          "titulo" => "Conflicts of Interest"
        ]
        10 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2015-03-09"
    "fechaAceptado" => "2015-05-21"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec592974"
          "palabras" => array:3 [
            0 => "Syphilis"
            1 => "Men who have sex with men"
            2 => "Human immunodeficiency virus"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec592973"
          "palabras" => array:3 [
            0 => "S&#237;filis"
            1 => "Hombres que tienen sexo con hombres"
            2 => "Virus de la inmunodeficiencia humana"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To describe the clinical and epidemiological characteristics of syphilis in men who have sex with men &#40;MSM&#41; in an area of Mallorca&#44; Spain&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We performed a retrospective analysis of syphilis cases in MSM seen at a hospital in Mallorca between January 2005 and June 2013&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Fifty-five cases of syphilis were recorded in MSM during the study period &#40;34&#46;3&#37; of all cases diagnosed&#41;&#44; and 74&#46;5&#37; of these patients had human immunodeficiency virus &#40;HIV&#41; coinfection&#46; The two diseases had been diagnosed simultaneously in 70&#46;7&#37; of this population&#46; Patients with HIV coinfection had a median CD4 count of 456<span class="elsevierStyleHsp" style=""></span>cells&#47;&#956;L &#40;range&#44; 29-979 cells&#47;&#956;L&#41;&#46; Syphilis was diagnosed clinically in 49&#46;1&#37; of cases and by screening in the remaining 50&#46;9&#37;&#46; The most common form of syphilis was late latent or indeterminate syphilis &#40;41&#46;9&#37; of cases&#41;&#46; In the group of men with syphilis&#44; MSM had a higher risk of HIV infection&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">A majority of MSM with syphilis had HIV coinfection&#46; HIV screening is therefore essential in this population and could even result in early diagnosis&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Objective"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Methods"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusions"
          ]
        ]
      ]
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objetivos</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Describir las caracter&#237;sticas clinicoepidemiol&#243;gicas de la s&#237;filis en la poblaci&#243;n de hombres que tienen sexo con hombres en un &#225;rea de Mallorca&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Revisi&#243;n retrospectiva de los casos de s&#237;filis en pacientes hombres que tienen sexo con hombres &#40;HSH&#41; entre enero de 2005 y junio de 2013 en un hospital de Mallorca&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Encontramos 55 casos de s&#237;filis en HSH&#44; el 34&#44;3&#37; de los casos de s&#237;filis del periodo de estudio&#46; El 74&#44;5&#37; ten&#237;an coinfecci&#243;n por el virus de la inmunodeficiencia humana &#40;VIH&#41;&#46; El 70&#44;7&#37; de los diagn&#243;sticos de infecci&#243;n por VIH y s&#237;filis fueron simult&#225;neos&#46; Los pacientes con infecci&#243;n por VIH ten&#237;an una mediana de CD4 de 456 &#40;29-979&#41;&#46; Se diagnosticaron por cl&#237;nica el 49&#44;1&#37; y por cribado el 50&#44;9&#37; de los casos&#46; La s&#237;filis latente tard&#237;a o indeterminada fue la entidad m&#225;s frecuente &#40;41&#44;9&#37;&#41;&#46; Los pacientes HSH ten&#237;an m&#225;s riego de estar infectados por VIH que los varones no HSH&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">La mayor&#237;a de pacientes HSH con s&#237;filis presentan coinfecci&#243;n por el VIH&#44; siendo por lo tanto fundamental el cribado de VIH en estos pacientes&#44; lo que incluso puede permitir un diagn&#243;stico temprano de la misma&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Objetivos"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "M&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusiones"
          ]
        ]
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; G&#225;llego-Lez&#225;un C&#44; Arrizabalaga Asenjo M&#44; Gonz&#225;lez-Moreno J&#44; Ferullo I&#44; Teslev A&#44; Fern&#225;ndez-Vaca V&#44; et al&#46; S&#237;filis en hombres que tienen sexo con hombres&#58; una alarma para la detecci&#243;n de infecci&#243;n por VIH&#46; Actas Dermosifiliogr&#46; 2015&#59;106&#58;740&#8211;745&#46;</p>"
      ]
    ]
    "multimedia" => array:4 [
      0 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Abbreviations&#58; ARV&#44; antiretroviral&#59; HIV&#44; human immunodeficiency virus&#59; MSM&#44; men who have sex with men&#59; STI&#44; sexually transmitted infection&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Variable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">MSM &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>55&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Heterosexual Men &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>39&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Smoking</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">28 &#40;50&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">18 &#40;46&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Alcoholism</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8 &#40;14&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;5&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">HIV infection</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">41 &#40;74&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12 &#40;30&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">HIV infection with ARV therapy</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12 &#40;29&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5 &#40;12&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Other STIs</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8 &#40;14&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;5&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Genital warts&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3 &#40;5&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;5&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Herpes simplex&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3 &#40;5&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Nongonococcal urethritis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;3&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Immigrants</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15 &#40;27&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11 &#40;28&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Previous syphilis</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13 &#40;23&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8 &#40;20&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab940636.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Clinical Characteristics of Male Patients &#40;MSM and Heterosexual Men&#41; With Syphilis&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Abbreviation&#58; MSM&#44; men who have sex with men&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Clinical Form&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">MSM &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>55&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Heterosexual Men &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>39&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Primary syphilis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9 &#40;16&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3 &#40;7&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Secondary syphilis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">14 &#40;25&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6 &#40;15&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Early latent syphilis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4 &#40;7&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;2&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Late latent syphilis or syphilis of unknown duration&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">23 &#40;41&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">27 &#40;69&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Neurosyphilis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5 &#40;9&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;5&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab940639.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Clinical Stage of Syphilis Cases in MSM and Heterosexual Men&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "tbl0015"
        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Abbreviations&#58; HIV&#44; human immunodeficiency virus&#59; MSM&#44; men who have sex with men&#59; NS&#44; not significant&#59; OR&#44; odds ratio&#59; STI&#44; sexually transmitted infection&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">MSM&#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>55&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Heterosexual Men&#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>39&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">P</span> Value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Diagnosis by screening&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">28 &#40;50&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">27 &#40;69&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Clinical diagnosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">27 &#40;49&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12 &#40;30&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Reinfection&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13 &#40;23&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8 &#40;20&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">HIV-infected&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">41 &#40;74&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12 &#40;30&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;&#160;&#46;0001&#59; OR&#44; 6&#46;59 &#40;95&#37; CI&#44; 2&#46;67-16&#46;26&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Other STIs&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8 &#40;14&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;5&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;034&#59; OR&#44; 3&#46;44 &#40;95&#37; CI&#44; 1&#46;07-11&#46;07&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab940638.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Comparative Analysis of Syphilis Cases in MSM and Heterosexual Men&#46;</p>"
        ]
      ]
      3 => array:7 [
        "identificador" => "tbl0020"
        "etiqueta" => "Table 4"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Abbreviations&#58; HIV&#44; human immunodeficiency virus&#59; NS&#44; not significant&#59; OR&#44; odds ratio&#59; STI&#44; sexually transmitted infection&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">HIV-Infected&#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>53&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Non-HIV-Infected&#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>41&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">P</span> Value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Diagnosis by screening&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">33 &#40;62&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">22 &#40;53&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Clinical diagnosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">20 &#40;37&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">19 &#40;46&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Reinfection&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16 &#40;30&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5 &#40;12&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;032&#59; OR&#44; 3&#46;11 &#40;95&#37; CI&#44; 1&#46;06-9&#46;03&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Other STIs&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8 &#40;15&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;4&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab940637.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Comparative Analysis of Syphilis Cases in HIV-Infected Men and Non-HIV-Infected Men&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:23 [
            0 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Centers for Disease Control and Prevention&#46; Sexually Transmitted Disease Surveillance 2012&#46; Atlanta&#58; U&#46;S&#46; Department of Health and Human Services&#59; 2013&#46; <a href="http://www.cdc.gov/std/stats">http&#58;&#47;&#47;www&#46;cdc&#46;gov&#47;std&#47;stats</a>&#46; Accessed November 29&#44; 2014&#46;"
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Centro Nacional de Epidemiolog&#237;a&#46; Instituto de Salud Carlos III&#46; Resultados de la vigilancia epidemiol&#243;gica de las enfermedades transmisibles&#46; Informe anual 2011&#46; Madrid&#44; 2013&#46; <a href="http://www.isciii.es/">http&#58;&#47;&#47;www&#46;isciii&#46;es</a>&#46; Accessed November 28&#44; 2014&#46;"
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidemiology of hospitalizations due to syphilis in large urban areas in Spain between 1997 and 2006"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "L&#46; Garc&#237;a-Garc&#237;a"
                            1 => "M&#46;C&#46; Ariza Meg&#237;a"
                            2 => "A&#46; Alvaro"
                            3 => "A&#46; Gil de Miguel"
                            4 => "R&#46; Gil-Prieto"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Sex Reprod Health&#46;"
                        "fecha" => "2010"
                        "volumen" => "1"
                        "paginaInicial" => "123"
                        "paginaFinal" => "127"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Reemergence of infectious syphilis among homosexual men and HIV coinfection in Barcelona&#44; 2002-2003"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; Vall-Mayans"
                            1 => "M&#46; Casals"
                            2 => "A&#46; Vives"
                            3 => "E&#46; Loureiro"
                            4 => "P&#46; Armengol"
                            5 => "B&#46; Sanz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Med Clin &#40;Barc&#41;&#46;"
                        "fecha" => "2006"
                        "volumen" => "126"
                        "paginaInicial" => "94"
                        "paginaFinal" => "96"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16472482"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increase in syphilis and gonorrhoea among men who have sex with men in Madrid"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "B&#46; Men&#233;ndez"
                            1 => "J&#46; Ballesteros"
                            2 => "P&#46; Clavo"
                            3 => "J&#46; del Romero"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Med Clin &#40;Barc&#41;&#46;"
                        "fecha" => "2005"
                        "volumen" => "125"
                        "paginaInicial" => "756"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16324473"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidemiological study of an epidemic outbreak of syphilis in Palmas de Gran Canaria"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Vilar"
                            1 => "L&#46; Dehesa"
                            2 => "A&#46;J&#46; G&#243;mez-Duaso"
                            3 => "J&#46; Bastida"
                            4 => "P&#46; Rivero"
                            5 => "J&#46; Dom&#237;nguez-Silva"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr&#46;"
                        "fecha" => "2007"
                        "volumen" => "98"
                        "paginaInicial" => "466"
                        "paginaFinal" => "469"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17669300"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Syphilis and HIV infection"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "R&#46; Palacios Mu&#241;oz"
                            1 => "J&#46; de la Fuente Aguado"
                            2 => "J&#46; Murillas Angoiti"
                            3 => "J&#46;M&#46; Nogueira Coito"
                            4 => "J&#46; Santos Gonz&#225;lez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Enferm Infecc Microbiol Clin&#46;"
                        "fecha" => "2006"
                        "volumen" => "24"
                        "numero" => "Suppl 2"
                        "paginaInicial" => "34"
                        "paginaFinal" => "39"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "2014 European Guideline on the Management of Syphilis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Janier"
                            1 => "V&#46; Hegyi"
                            2 => "N&#46; Dupin"
                            3 => "M&#46; Unemo"
                            4 => "G&#46;S&#46; Tiplica"
                            5 => "M&#46; Potocnik"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:2 [
                        "fecha" => "2014"
                        "editorial" => "European Academy of Dermatology and Venereology"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ensayo Immulite 2000 Syphilis screen en cribado de s&#237;filis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Sampedro"
                            1 => "A&#46; Padilla"
                            2 => "L&#46; Aliagac"
                            3 => "J&#46; S&#225;nchez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Enferm Infecc Microbiol Clin&#46;"
                        "fecha" => "2011"
                        "volumen" => "2"
                        "paginaInicial" => "156"
                        "paginaFinal" => "161"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence of HIV and syphilis infection among men who have sex with men in China&#58; A meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "Y&#46; Zhou"
                            1 => "D&#46; Li"
                            2 => "D&#46; Lu"
                            3 => "Y&#46; Ruan"
                            4 => "X&#46; Qi"
                            5 => "G&#46; Gao"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1155/2014/620431"
                      "Revista" => array:5 [
                        "tituloSerie" => "Biomed Res Int&#46;"
                        "fecha" => "2014"
                        "volumen" => "2014"
                        "paginaInicial" => "620431"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24868533"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Syphilis control &#8212;a continuing challenge"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "E&#46;W&#46;JIII Hook"
                            1 => "R&#46;W&#46; Peeling"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMp048126"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2004"
                        "volumen" => "351"
                        "paginaInicial" => "122"
                        "paginaFinal" => "124"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15247352"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Condom use and number of sexual partners among male syphilis patients who report having sex with men"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "B&#46; Repiso"
                            1 => "M&#46; Frieyro"
                            2 => "F&#46; Rivas-Ruiz"
                            3 => "M&#46; de Troya"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr&#46;"
                        "fecha" => "2010"
                        "volumen" => "101"
                        "paginaInicial" => "847"
                        "paginaFinal" => "852"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21159260"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence of HIV and syphilis infection among high school and college student MSM in China&#58; A systematic review and meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Y&#46; Li"
                            1 => "J&#46; Xu"
                            2 => "K&#46;H&#46; Reilly"
                            3 => "J&#46; Zhang"
                            4 => "H&#46; Wei"
                            5 => "Y&#46; Jiang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "PLoSOne&#46;"
                        "fecha" => "2013"
                        "volumen" => "8"
                        "paginaInicial" => "e69137"
                        "itemHostRev" => array:3 [
                          "pii" => "S0140673612602359"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Syphilis and HIV&#58; A dangerous combination"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "W&#46;A&#46; Lynn"
                            1 => "S&#46; Lightman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S1473-3099(04)01061-8"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet Infect Dis&#46;"
                        "fecha" => "2004"
                        "volumen" => "4"
                        "paginaInicial" => "456"
                        "paginaFinal" => "466"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15219556"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of HIV infection on the course of syphilis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "G&#46; Pialoux"
                            1 => "S&#46; Vimont"
                            2 => "A&#46; Moulignier"
                            3 => "M&#46; Buteux"
                            4 => "B&#46; Abraham"
                            5 => "P&#46; Bonnard"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "AIDS Rev&#46;"
                        "fecha" => "2008"
                        "volumen" => "10"
                        "paginaInicial" => "85"
                        "paginaFinal" => "92"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18615119"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "HIV&#44; syphilis and sexual risk behaviours among men who have sex with men in Agadir and Marrakesh&#44; Morocco"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46;G&#46; Johnston"
                            1 => "K&#46; Alami"
                            2 => "M&#46;H&#46; el Rhilani"
                            3 => "M&#46; Karkouri"
                            4 => "O&#46; Mellouk"
                            5 => "A&#46; Abadie"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Sex Transm Infect&#46;"
                        "fecha" => "2013"
                        "volumen" => "89"
                        "numero" => "Suppl 3"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "HIV-1&#44; HBV&#44; HCV&#44; HTLV HPV-16&#47;18&#44; and <span class="elsevierStyleItalic">Treponema pallidum</span> infections in a sample of Brazilian men who have sex with men"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46;C&#46; Soares"
                            1 => "I&#46; Georg"
                            2 => "E&#46; Lampe"
                            3 => "L&#46; Lewis"
                            4 => "M&#46;G&#46; Morgado"
                            5 => "A&#46;F&#46; Nicol"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1371/journal.pone.0102676"
                      "Revista" => array:5 [
                        "tituloSerie" => "PLoS One&#46;"
                        "fecha" => "2014"
                        "volumen" => "9"
                        "paginaInicial" => "e102676"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25083768"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0205"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "High risk for HIV following syphilis diagnosis among men in Florida&#44; 2000-2011"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "T&#46;A&#46; Peterman"
                            1 => "D&#46;R&#46; Newman"
                            2 => "L&#46; Maddox"
                            3 => "K&#46; Schmitt"
                            4 => "S&#46; Shiver"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Public Health Rep&#46;"
                        "fecha" => "2014"
                        "volumen" => "129"
                        "paginaInicial" => "164"
                        "paginaFinal" => "169"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24587551"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Characteristics and risk of syphilis diagnosis among HIV-infected male cohort&#58; A population based study in Houston&#44; Texas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "B&#46; Yang"
                            1 => "C&#46;J&#46; Hallmark"
                            2 => "J&#46;S&#46; Huang"
                            3 => "M&#46;L&#46; Wolverton"
                            4 => "M&#46; McNeese-Ward"
                            5 => "R&#46;R&#46; Arafat"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/OLQ.0000000000000056"
                      "Revista" => array:6 [
                        "tituloSerie" => "Sex Transm Dis&#46;"
                        "fecha" => "2013"
                        "volumen" => "40"
                        "paginaInicial" => "957"
                        "paginaFinal" => "963"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24220358"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "HIV&#47;STI co-infection among men who have sex with men in Spain"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "STI Study Group and EPI-VIH Group"
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Diaz"
                            1 => "M&#46;L&#46; Junquera"
                            2 => "V&#46; Esteban"
                            3 => "B&#46; Mart&#237;nez"
                            4 => "I&#46; Pueyo"
                            5 => "J&#46; Suarez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "Euro Surveill"
                        "fecha" => "2009"
                        "paginaInicial" => "14"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0220"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Current standards for diagnosis and treatment of syphilis&#58; Selection of some practical issues&#44; based on the European &#40;IUSTI&#41; and U&#46;S&#46; &#40;CDC&#41; guidelines"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46; Pastuszczak"
                            1 => "A&#46; Wojas-Pelc"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.5114/pdia.2013.37029"
                      "Revista" => array:6 [
                        "tituloSerie" => "Postepy Dermatol Alergol&#46;"
                        "fecha" => "2013"
                        "volumen" => "30"
                        "paginaInicial" => "203"
                        "paginaFinal" => "210"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24278076"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "IUSTI&#58; IUST 2008 European guidelines on the management of syphilis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "P&#46; French"
                            1 => "M&#46; Gomberg"
                            2 => "M&#46; Janier"
                            3 => "B&#46; Schmidt"
                            4 => "P&#46; van VoorstVader"
                            5 => "H&#46; Young"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1258/ijsa.2008.008510"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J STD AIDS"
                        "fecha" => "2009"
                        "volumen" => "20"
                        "paginaInicial" => "300"
                        "paginaFinal" => "309"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19386965"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Centers for Disease Control and Prevention &#40;CDC&#41; Sexually transmitted diseases treatment guidelines&#44; 2010"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "K&#46;A&#46; Workowski"
                            1 => "S&#46; Berman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "MMWR Recomm Rep&#46;"
                        "fecha" => "2010"
                        "volumen" => "59"
                        "paginaInicial" => "1"
                        "paginaFinal" => "110"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21160459"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010600000009/v1_201511040157/S1578219015002383/v1_201511040157/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6155"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Original Articles"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010600000009/v1_201511040157/S1578219015002383/v1_201511040157/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015002383?idApp=UINPBA000044"
]
Article information
ISSN: 15782190
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 11 9 20
2024 October 82 49 131
2024 September 88 38 126
2024 August 142 71 213
2024 July 111 52 163
2024 June 98 31 129
2024 May 80 31 111
2024 April 72 20 92
2024 March 85 23 108
2024 February 118 37 155
2024 January 65 40 105
2023 December 53 14 67
2023 November 71 28 99
2023 October 73 29 102
2023 September 95 34 129
2023 August 49 13 62
2023 July 47 31 78
2023 June 51 26 77
2023 May 57 33 90
2023 April 27 11 38
2023 March 59 32 91
2023 February 51 38 89
2023 January 31 39 70
2022 December 52 57 109
2022 November 45 50 95
2022 October 25 25 50
2022 September 16 51 67
2022 August 25 39 64
2022 July 26 47 73
2022 June 22 29 51
2022 May 46 62 108
2022 April 67 46 113
2022 March 66 66 132
2022 February 48 33 81
2022 January 47 45 92
2021 December 25 40 65
2021 November 41 53 94
2021 October 37 47 84
2021 September 26 37 63
2021 August 28 26 54
2021 July 33 30 63
2021 June 28 38 66
2021 May 53 24 77
2021 April 74 44 118
2021 March 68 28 96
2021 February 90 38 128
2021 January 57 28 85
2020 December 56 28 84
2020 November 53 20 73
2020 October 38 16 54
2020 September 52 21 73
2020 August 39 20 59
2020 July 32 22 54
2020 June 51 25 76
2020 May 45 24 69
2020 April 36 22 58
2020 March 53 29 82
2020 February 6 0 6
2019 December 4 3 7
2019 November 0 1 1
2019 October 0 2 2
2019 September 4 0 4
2019 August 0 1 1
2019 July 0 2 2
2019 June 2 1 3
2019 May 0 7 7
2019 April 0 7 7
2019 March 2 4 6
2019 February 0 1 1
2019 January 2 0 2
2018 December 2 2 4
2018 November 1 0 1
2018 October 2 2 4
2018 September 5 0 5
2018 June 0 1 1
2018 May 0 5 5
2018 April 0 2 2
2018 March 1 0 1
2018 February 22 3 25
2018 January 26 9 35
2017 December 23 10 33
2017 November 30 8 38
2017 October 23 8 31
2017 September 21 15 36
2017 August 25 12 37
2017 July 29 7 36
2017 June 28 20 48
2017 May 29 15 44
2017 April 20 11 31
2017 March 16 57 73
2017 February 20 8 28
2017 January 14 5 19
2016 December 25 15 40
2016 November 39 39 78
2016 October 24 23 47
2016 September 0 4 4
2016 August 0 1 1
2016 July 0 1 1
2016 June 1 1 2
2016 May 0 10 10
2016 March 0 5 5
2016 February 0 6 6
2016 January 0 4 4
2015 November 0 13 13
Show all

Follow this link to access the full text of the article

Idiomas
Actas Dermo-Sifiliográficas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?