Case and Research Letter
Psoriatic Cheilitis: A Report of 2 Cases Treated Successfully With Topical Tacrolimus and a Review of the Literature
Queilitis psoriásica: Un reporte de 2 casos tratados con éxito con tacrolimus tópico y revisión de la literatura
Read
6012
Timeswas read the article
2413
Total PDF
3599
Total HTML
Share statistics
array:24 [ "pii" => "S1578219015002371" "issn" => "15782190" "doi" => "10.1016/j.adengl.2015.09.002" "estado" => "S300" "fechaPublicacion" => "2015-10-01" "aid" => "1174" "copyright" => "Elsevier España, S.L.U. and AEDV" "copyrightAnyo" => "2014" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "cor" "cita" => "Actas Dermosifiliogr. 2015;106:687-9" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 827 "formatos" => array:3 [ "EPUB" => 54 "HTML" => 340 "PDF" => 433 ] ] "Traduccion" => array:1 [ "en" => array:19 [ "pii" => "S0001731015002045" "issn" => "00017310" "doi" => "10.1016/j.ad.2015.01.016" "estado" => "S300" "fechaPublicacion" => "2015-10-01" "aid" => "1174" "copyright" => "Elsevier España, S.L.U. and AEDV" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2015;106:687-9" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 781 "formatos" => array:3 [ "EPUB" => 47 "HTML" => 320 "PDF" => 414 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>" "titulo" => "Psoriatic Cheilitis: A Report of 2 Cases Treated Successfully With Topical Tacrolimus and a Review of the Literature" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "687" "paginaFinal" => "689" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Queilitis psoriásica: Un reporte de 2 casos tratados con éxito con tacrolimus tópico y revisión de la literatura" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 542 "Ancho" => 1500 "Tamanyo" => 132517 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">(a) Whitish scales on the vermilion borders of both lips in patient 2 before treatment. (b) Mounds of parakeratosis and hypogranulosis, acanthosis, and dilated, vertically elongated papillary vessels (hematoxylin-eosin, original magnification ×20).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Z. Apalla, E. Sotiriou, A. Trigoni, D. Ioannides" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Z." "apellidos" => "Apalla" ] 1 => array:2 [ "nombre" => "E." "apellidos" => "Sotiriou" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Trigoni" ] 3 => array:2 [ "nombre" => "D." "apellidos" => "Ioannides" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S1578219015002371" "doi" => "10.1016/j.adengl.2015.09.002" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015002371?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015002045?idApp=UINPBA000044" "url" => "/00017310/0000010600000008/v1_201510020746/S0001731015002045/v1_201510020746/en/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S1578219015002139" "issn" => "15782190" "doi" => "10.1016/j.adengl.2015.07.015" "estado" => "S300" "fechaPublicacion" => "2015-10-01" "aid" => "1177" "copyright" => "Elsevier España, S.L.U. and AEDV" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "cor" "cita" => "Actas Dermosifiliogr. 2015;106:689-91" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1230 "formatos" => array:3 [ "EPUB" => 43 "HTML" => 805 "PDF" => 382 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>" "titulo" => "Use of the Burow Triangle or Wedge-shaped Resection During the Repair of Infraorbital Defects" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "689" "paginaFinal" => "691" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Uso del triángulo de Burow o escisión en «V» para la reparación de defectos infraorbitarios" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1151 "Ancho" => 1150 "Tamanyo" => 241338 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Case 1. Surgical resection of a malignant tumor leaving a defect in the infraorbital region. Closure using a Burow triangle or wedge-shaped resection.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "L.M. Molinari, D. Ferrario, G.N. Galimberti" "autores" => array:3 [ 0 => array:2 [ "nombre" => "L.M." "apellidos" => "Molinari" ] 1 => array:2 [ "nombre" => "D." "apellidos" => "Ferrario" ] 2 => array:2 [ "nombre" => "G.N." "apellidos" => "Galimberti" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731015002070" "doi" => "10.1016/j.ad.2014.12.026" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015002070?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015002139?idApp=UINPBA000044" "url" => "/15782190/0000010600000008/v1_201510011018/S1578219015002139/v1_201510011018/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S1578219015002097" "issn" => "15782190" "doi" => "10.1016/j.adengl.2015.07.011" "estado" => "S300" "fechaPublicacion" => "2015-10-01" "aid" => "1173" "copyright" => "Elsevier España, S.L.U. and AEDV" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "cor" "cita" => "Actas Dermosifiliogr. 2015;106:685-7" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1036 "formatos" => array:3 [ "EPUB" => 54 "HTML" => 608 "PDF" => 374 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>" "titulo" => "Diffuse Systemic Large B-Cell Lymphoma With Secondary Skin Involvement" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "685" "paginaFinal" => "687" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Linfoma B difuso de células grandes sistémico con afectación cutánea secundaria" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1263 "Ancho" => 1682 "Tamanyo" => 314385 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Indurated erythematous-violaceous plaque.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "C. Lloret-Ruiz, P. Molés-Poveda, N. Barrado-Solís, E. Gimeno-Carpio" "autores" => array:4 [ 0 => array:2 [ "nombre" => "C." "apellidos" => "Lloret-Ruiz" ] 1 => array:2 [ "nombre" => "P." "apellidos" => "Molés-Poveda" ] 2 => array:2 [ "nombre" => "N." "apellidos" => "Barrado-Solís" ] 3 => array:2 [ "nombre" => "E." "apellidos" => "Gimeno-Carpio" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731015002033" "doi" => "10.1016/j.ad.2015.02.012" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015002033?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015002097?idApp=UINPBA000044" "url" => "/15782190/0000010600000008/v1_201510011018/S1578219015002097/v1_201510011018/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>" "titulo" => "Psoriatic Cheilitis: A Report of 2 Cases Treated Successfully With Topical Tacrolimus and a Review of the Literature" "tieneTextoCompleto" => true "saludo" => "Dear Editor," "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "687" "paginaFinal" => "689" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Z. Apalla, E. Sotiriou, A. Trigoni, D. Ioannides" "autores" => array:4 [ 0 => array:3 [ "nombre" => "Z." "apellidos" => "Apalla" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 1 => array:4 [ "nombre" => "E." "apellidos" => "Sotiriou" "email" => array:1 [ 0 => "elenasotiriou@yahoo.gr" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 2 => array:3 [ "nombre" => "A." "apellidos" => "Trigoni" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "D." "apellidos" => "Ioannides" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "State Clinic, Hospital of Skin and Venereal Diseases, Thessaloniki, Greece" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "First Dermatology Department, Aristotle University of Thessaloniki, Greece" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Queilitis psoriásica: Un reporte de 2 casos tratados con éxito con tacrolimus tópico y revisión de la literatura" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 904 "Ancho" => 2500 "Tamanyo" => 258717 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">(a) Whitish scales on the vermilion borders of both lips in patient 2 before treatment. (b) Mounds of parakeratosis and hypogranulosis, acanthosis, and dilated, vertically elongated papillary vessels (hematoxylin-eosin, original magnification ×20).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Psoriasis is a chronic inflammatory skin disease that typically affects the extremities, trunk, scalp, and nails. Psoriatic cheilitis as an exclusive presentation is very rare,<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> and to our knowledge, only 5 cases have been reported to date.<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2–6</span></a> The absence of cutaneous lesions causes diagnostic difficulties that can result in misdiagnosis and inadequate treatment.</p><p id="par0010" class="elsevierStylePara elsevierViewall">We report the cases of 2 young adults who presented with psoriasis of the vermilion of the lips as the only disease manifestation. Response to topical tacrolimus 0.1% treatment was good in both cases.</p><p id="par0015" class="elsevierStylePara elsevierViewall">The first case involved a 28-year-old white woman referred to our clinic with a 3-month history of scaly plaques on the vermilion of her lips and a clinical diagnosis of contact cheilitis. Clinical examination revealed an erythematous fissured plaque over the entire upper and lower lip surface, covered by thick white-yellowish scales (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>A). Full body examination did not reveal any evidence of intraoral or cutaneous involvement. Apart from a 10-year history of Hashimoto thyroiditis, the patient's medical history was unremarkable. However, she did mention that her brother had psoriasis. Contact cheilitis was excluded following negative patch tests. Subsequent biopsy and histological examination confirmed the clinical suspicion of psoriasis. The patient received initial treatment with salicylic acid 5% ointment twice daily for 5 days, followed by a 1-month course of topical tacrolimus 0.1% twice daily, resulting in adequate control of disease activity (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>B). The patient is currently on maintenance treatment with twice-weekly application of tacrolimus 0.1% ointment.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">The second case involved a 20-year-old white man referred to our clinic for further assessment of a 2-year history of recurrent erosive cheilitis, characterized by fissures and white-yellowish scales on the vermilion borders of both lips (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>A). Intraoral and cutaneous lesions were absent. The patient reported exacerbations, particularly during winter. His medical history was unremarkable; there was, however, a positive family history of psoriasis (his mother). After excluding contact cheilitis by patch testing, we performed a lip biopsy. Histopathology showed mounds of parakeratosis and hypogranulosis, acanthosis, and dilated and vertically elongated papillary vessels (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>B), leading to a diagnosis of psoriatic cheilitis. The patient was started on salicylic acid 5% twice daily for 3 days, followed by topical tacrolimus 0.1% twice daily for the next month. The treatment resulted in the gradual remission of lesions, but discontinuation led to a flare-up, which was managed with the same regimen. To avoid recurrences the patient was advised to use tacrolimus 0.1% twice weekly, with excellent results.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Perioral psoriasis is an unusual presentation of psoriasis. It is clinically characterized by cracking and scaling of the lips and can have a profound emotional, social, and physical impact on patients’ lives.<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1,4</span></a> In the vast majority of the cases, coexistence of typical psoriatic lesions elsewhere on the body facilitates diagnosis. To the best of our knowledge, exclusive lip involvement is very uncommon, with only 5 cases reported in the literature.<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2–6</span></a> In 2 of these cases, involvement of the vermilion of the lips preceded cutaneous manifestations by at least 2 months.<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">5,6</span></a> Brenner et al.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a> reported a case of psoriatic cheilitis triggered by protruding teeth as a result of Koebner phenomenon; the condition was resolved by replacing the teeth with a nonirritating prosthesis. <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> summarizes the main epidemiological and clinical characteristics of all the cases reported to date, including ours. Perioral psoriasis as a single site of involvement can pose significant diagnostic difficulties. Due to a lack of specific diagnostic criteria, it has been suggested that a chronic course, with resistance to treatment and frequent recurrences, should raise the suspicion of psoriatic cheilitis.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> A positive family history and HLA typing have also been described as important in supporting the a diagnosis of perioral psoriasis.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">Therapeutic modalities such as topical steroids and tacrolimus alone or in combination with calcipotriol have produced adequate response in patients with perioral psoriasis.<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2–6,8</span></a> Tacrolimus, a calcineurin-inhibitor with anti-inflammatory properties, lacks the well-known adverse effects associated with steroids. Yamamoto and Nishioka<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> reported a case in which topical tacrolimus ointment was used to treat psoriasis of the vermilion of the lips, with very promising results. Moreover, this treatment combined with salicylic acid gel has been shown to increase the penetration and absorption of the drug, enhancing therapeutic action.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">In conclusion, we have described 2 new cases of psoriatic cheilitis with exclusive lip involvement treated successfully with topical tacrolimus 0.1% in combination with salicylic acid, indicating their possible therapeutic role in this troublesome localization. We suggest that psoriasis should be considered in cases of refractory long-standing eczema-like cheilitis, even in the absence of a positive family or personal history of psoriasis.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 740 "Ancho" => 2503 "Tamanyo" => 152374 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(a) Thick white-yellowish scales strongly attached to the lips of patient #1 before treatment. (b) Resolution of lesions after treatment with topical tacrolimus.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 904 "Ancho" => 2500 "Tamanyo" => 258717 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">(a) Whitish scales on the vermilion borders of both lips in patient 2 before treatment. (b) Mounds of parakeratosis and hypogranulosis, acanthosis, and dilated, vertically elongated papillary vessels (hematoxylin-eosin, original magnification ×20).</p>" ] ] 2 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Abbreviations</span>: CR, complete response; F, female; M, male.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Sex \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Age, y \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Skin lesions at presentation \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Oral lesions \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Treatment \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Outcome \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Exclusive lip involvement \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Tosti et al.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">24 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Steroid cream \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">CR \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Yes \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Rahman et al.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Triamcinolone acetonide ointment \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">CR \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Yes \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Sehgal et al.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">16 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Tacrolimus<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>calcipotriol<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>betamethasone dipropionate \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">CR \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Yes \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Ersoy-Evans et al.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">19 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Fluticasone propionate 0.005% ointment \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">CR \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">No \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Baz et al.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">22 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Mometasone furoate 0.1% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">CR \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">No \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " rowspan="2" align="left" valign="top">Current cases</td><td class="td" title="table-entry " align="left" valign="top">M \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Tacrolimus<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>salicylic acid \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">CR \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Yes \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">F \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">28 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Tacrolimus<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>salicylic acid \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">CR \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Yes \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab908838.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Summary of cases of psoriatic cheilitis reported in the literature.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0055" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Oral psoriasis: report of a case and review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A. Sklavounou" 1 => "G. Laskaris" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Dermatologica" "fecha" => "1990" "volumen" => "180" "paginaInicial" => "157" "paginaFinal" => "159" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2187720" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0060" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Guess what! Psoriasis of the lips" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. Tosti" 1 => "C. Misciali" 2 => "N. Cameli" 3 => "C. Vincenzi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur J Dermatol" "fecha" => "2001" "volumen" => "11" "paginaInicial" => "589" "paginaFinal" => "590" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11701417" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0065" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Perioral psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M.A. Rahman" 1 => "M. Fikree" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Eur Acad Dermatol Venereol" "fecha" => "2000" "volumen" => "14" "paginaInicial" => "521" "paginaFinal" => "522" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11444285" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0070" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Exclusive plaque psoriasis of the lips: efficacy of combination therapy of topical tacrolimus, calcipotriol, and betamethasone dipropionate" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "V.N. Sehgal" 1 => "S. Sehgal" 2 => "P. Verma" 3 => "N. Singh" 4 => "F. Rasool" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "J Skin Med" "fecha" => "2012" "volumen" => "10" "paginaInicial" => "183" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0075" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Psoriasis of the lips: a rare entity" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S. Ersoy-Evans" 1 => "L. Nuralina" 2 => "G. Erkin" 3 => "O. Ozkaya" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1468-3083.2006.01824.x" "Revista" => array:6 [ "tituloSerie" => "J Eur Acad Dermatol Venereol" "fecha" => "2007" "volumen" => "21" "paginaInicial" => "142" "paginaFinal" => "143" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17207203" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0080" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Isolated lip involvement in psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "K. Baz" 1 => "A.C. Yazici" 2 => "A. Usta" 3 => "G. Ikizoglu" 4 => "D.D. Apa" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2230.2007.02445.x" "Revista" => array:6 [ "tituloSerie" => "Clin Exp Dermatol" "fecha" => "2007" "volumen" => "32" "paginaInicial" => "578" "paginaFinal" => "579" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17501965" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0085" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Psoriasis of the lips: the unusual Köbner phenomenon caused by protruding upper teeth" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S. Brenner" 1 => "R. Lipitz" 2 => "B. Llie" 3 => "A. Krakowski" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Dermatologica" "fecha" => "1982" "volumen" => "164" "paginaInicial" => "413" "paginaFinal" => "416" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7117646" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0090" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Psoriasis of the lips" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "N. Martí" 1 => "I. Pinazo" 2 => "A. Revert" 3 => "E. Jordá" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3315/jdcr.2009.1036" "Revista" => array:6 [ "tituloSerie" => "J Dermatol Case Rep" "fecha" => "2009" "volumen" => "3" "paginaInicial" => "50" "paginaFinal" => "52" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21886732" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0095" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Successful treatment with topical tacrolimus for oral psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "T. Yamamoto" 1 => "K. Nishioka" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1468-3083.2006.01630.x" "Revista" => array:6 [ "tituloSerie" => "J Eur Acad Dermatol Venereol" "fecha" => "2006" "volumen" => "20" "paginaInicial" => "1137" "paginaFinal" => "1138" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16987275" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0100" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tacrolimus ointment for the treatment of psoriasis on the face and intertriginous areas" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A.K. Freeman" 1 => "G.J. Linowski" 2 => "C. Brady" 3 => "L. Lind" 4 => "P. Vanveldhuisen" 5 => "G. Singer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1067/mjd.2003.169" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2003" "volumen" => "48" "paginaInicial" => "564" "paginaFinal" => "568" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12664020" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010600000008/v1_201510011018/S1578219015002371/v1_201510011018/en/main.assets" "Apartado" => array:4 [ "identificador" => "6157" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Case and Research Letters" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010600000008/v1_201510011018/S1578219015002371/v1_201510011018/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015002371?idApp=UINPBA000044" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 6 | 7 | 13 |
| 2024 October | 64 | 40 | 104 |
| 2024 September | 72 | 28 | 100 |
| 2024 August | 99 | 55 | 154 |
| 2024 July | 55 | 36 | 91 |
| 2024 June | 85 | 45 | 130 |
| 2024 May | 70 | 32 | 102 |
| 2024 April | 77 | 21 | 98 |
| 2024 March | 67 | 26 | 93 |
| 2024 February | 59 | 32 | 91 |
| 2024 January | 54 | 35 | 89 |
| 2023 December | 58 | 27 | 85 |
| 2023 November | 68 | 29 | 97 |
| 2023 October | 55 | 48 | 103 |
| 2023 September | 45 | 38 | 83 |
| 2023 August | 47 | 28 | 75 |
| 2023 July | 65 | 57 | 122 |
| 2023 June | 72 | 28 | 100 |
| 2023 May | 112 | 40 | 152 |
| 2023 April | 68 | 45 | 113 |
| 2023 March | 59 | 36 | 95 |
| 2023 February | 59 | 31 | 90 |
| 2023 January | 46 | 38 | 84 |
| 2022 December | 62 | 44 | 106 |
| 2022 November | 45 | 24 | 69 |
| 2022 October | 46 | 20 | 66 |
| 2022 September | 63 | 47 | 110 |
| 2022 August | 42 | 39 | 81 |
| 2022 July | 41 | 36 | 77 |
| 2022 June | 43 | 24 | 67 |
| 2022 May | 64 | 59 | 123 |
| 2022 April | 115 | 45 | 160 |
| 2022 March | 119 | 67 | 186 |
| 2022 February | 114 | 42 | 156 |
| 2022 January | 121 | 66 | 187 |
| 2021 December | 60 | 51 | 111 |
| 2021 November | 88 | 54 | 142 |
| 2021 October | 51 | 61 | 112 |
| 2021 September | 44 | 35 | 79 |
| 2021 August | 48 | 29 | 77 |
| 2021 July | 33 | 37 | 70 |
| 2021 June | 28 | 39 | 67 |
| 2021 May | 32 | 30 | 62 |
| 2021 April | 97 | 35 | 132 |
| 2021 March | 75 | 39 | 114 |
| 2021 February | 49 | 40 | 89 |
| 2021 January | 40 | 22 | 62 |
| 2020 December | 44 | 19 | 63 |
| 2020 November | 32 | 22 | 54 |
| 2020 October | 27 | 12 | 39 |
| 2020 September | 36 | 16 | 52 |
| 2020 August | 21 | 22 | 43 |
| 2020 July | 34 | 18 | 52 |
| 2020 June | 24 | 37 | 61 |
| 2020 May | 14 | 18 | 32 |
| 2020 April | 20 | 16 | 36 |
| 2020 March | 24 | 13 | 37 |
| 2020 February | 1 | 0 | 1 |
| 2020 January | 0 | 2 | 2 |
| 2019 December | 4 | 2 | 6 |
| 2019 November | 0 | 6 | 6 |
| 2019 October | 0 | 4 | 4 |
| 2019 September | 6 | 9 | 15 |
| 2019 August | 0 | 5 | 5 |
| 2019 July | 0 | 6 | 6 |
| 2019 June | 0 | 7 | 7 |
| 2019 May | 3 | 20 | 23 |
| 2019 April | 2 | 26 | 28 |
| 2019 March | 0 | 8 | 8 |
| 2019 February | 2 | 4 | 6 |
| 2018 December | 4 | 0 | 4 |
| 2018 November | 2 | 0 | 2 |
| 2018 October | 3 | 0 | 3 |
| 2018 September | 7 | 0 | 7 |
| 2018 June | 0 | 6 | 6 |
| 2018 May | 0 | 11 | 11 |
| 2018 April | 0 | 2 | 2 |
| 2018 March | 0 | 3 | 3 |
| 2018 February | 19 | 8 | 27 |
| 2018 January | 17 | 9 | 26 |
| 2017 December | 22 | 11 | 33 |
| 2017 November | 17 | 7 | 24 |
| 2017 October | 21 | 18 | 39 |
| 2017 September | 15 | 12 | 27 |
| 2017 August | 23 | 13 | 36 |
| 2017 July | 19 | 19 | 38 |
| 2017 June | 15 | 44 | 59 |
| 2017 May | 25 | 22 | 47 |
| 2017 April | 20 | 13 | 33 |
| 2017 March | 11 | 50 | 61 |
| 2017 February | 12 | 7 | 19 |
| 2017 January | 8 | 8 | 16 |
| 2016 December | 16 | 15 | 31 |
| 2016 November | 23 | 11 | 34 |
| 2016 October | 21 | 11 | 32 |
| 2016 September | 0 | 5 | 5 |
| 2016 August | 0 | 8 | 8 |
| 2016 July | 0 | 2 | 2 |
| 2016 June | 3 | 5 | 8 |
| 2016 May | 0 | 2 | 2 |
| 2016 April | 0 | 4 | 4 |
| 2016 February | 0 | 4 | 4 |
| 2016 January | 0 | 1 | 1 |
| 2015 November | 0 | 3 | 3 |
Show all
