array:24 [
  "pii" => "S1578219015002024"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2015.07.004"
  "estado" => "S300"
  "fechaPublicacion" => "2015-10-01"
  "aid" => "1145"
  "copyright" => "Elsevier España, S.L.U. and AEDV"
  "copyrightAnyo" => "2014"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "cor"
  "cita" => "Actas Dermosifiliogr. 2015;106:676-8"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 908
    "formatos" => array:3 [
      "EPUB" => 48
      "HTML" => 479
      "PDF" => 381
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0001731015001295"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2014.12.022"
      "estado" => "S300"
      "fechaPublicacion" => "2015-10-01"
      "aid" => "1145"
      "copyright" => "Elsevier España, S.L.U. y AEDV"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "crp"
      "cita" => "Actas Dermosifiliogr. 2015;106:676-8"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 744
        "formatos" => array:3 [
          "EPUB" => 2
          "HTML" => 378
          "PDF" => 364
        ]
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta cient&#237;fico-cl&#237;nica</span>"
        "titulo" => "Alopecia e hirsutismo en una mujer posmenop&#225;usica como forma de presentaci&#243;n de un tumor de c&#233;lulas de Leydig hiliar del ovario"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "676"
            "paginaFinal" => "678"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Alopecia and Hirsutism in a Postmenopausal Woman as the Presenting Complaint of Ovarian Hilus &#40;Leydig&#41; Cell Tumor"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0015"
            "etiqueta" => "Figura 3"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr3.jpeg"
                "Alto" => 1120
                "Ancho" => 975
                "Tamanyo" => 161737
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">N&#243;dulo suprarrenal izquierdo de 2&#44;6<span class="elsevierStyleHsp" style=""></span>cm&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "L&#46; Berbegal, M&#46;P&#46; Albares, F&#46;J&#46; De-Leon, G&#46; Negueruela"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "L&#46;"
                "apellidos" => "Berbegal"
              ]
              1 => array:2 [
                "nombre" => "M&#46;P&#46;"
                "apellidos" => "Albares"
              ]
              2 => array:2 [
                "nombre" => "F&#46;J&#46;"
                "apellidos" => "De-Leon"
              ]
              3 => array:2 [
                "nombre" => "G&#46;"
                "apellidos" => "Negueruela"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219015002024"
          "doi" => "10.1016/j.adengl.2015.07.004"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015002024?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015001295?idApp=UINPBA000044"
      "url" => "/00017310/0000010600000008/v1_201510020746/S0001731015001295/v1_201510020746/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1578219015002036"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2015.07.005"
    "estado" => "S300"
    "fechaPublicacion" => "2015-10-01"
    "aid" => "1146"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2015;106:678-80"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 880
      "formatos" => array:3 [
        "EPUB" => 44
        "HTML" => 547
        "PDF" => 289
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
      "titulo" => "Diagnostic Value of Color Doppler Ultrasound for Cutaneous Odontogenic Sinus Tract"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "678"
          "paginaFinal" => "680"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Utilidad de la ecograf&#237;a doppler color para el diagn&#243;stico de f&#237;stulas dentocut&#225;neas"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1667
              "Ancho" => 1251
              "Tamanyo" => 381212
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Cutaneous horn sunken into the skin over the left horizontal ramus of the mandible&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "C&#46; Garrido Colmenero, G&#46; Blasco Morente, J&#46;M&#46; Latorre Fuentes, R&#46; Ruiz Villaverde"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Garrido Colmenero"
            ]
            1 => array:2 [
              "nombre" => "G&#46;"
              "apellidos" => "Blasco Morente"
            ]
            2 => array:2 [
              "nombre" => "J&#46;M&#46;"
              "apellidos" => "Latorre Fuentes"
            ]
            3 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Ruiz Villaverde"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731015001301"
        "doi" => "10.1016/j.ad.2014.12.023"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015001301?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015002036?idApp=UINPBA000044"
    "url" => "/15782190/0000010600000008/v1_201510011018/S1578219015002036/v1_201510011018/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1578219015002012"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2015.07.003"
    "estado" => "S300"
    "fechaPublicacion" => "2015-10-01"
    "aid" => "1143"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2015;106:675-6"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 976
      "formatos" => array:3 [
        "EPUB" => 41
        "HTML" => 558
        "PDF" => 377
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
      "titulo" => "Cell Phone-Induced Chondrodermatitis Nodularis Antihelicis"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "675"
          "paginaFinal" => "676"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Condrodermatitis nodular del antih&#233;lix por tel&#233;fono m&#243;vil"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1221
              "Ancho" => 1628
              "Tamanyo" => 324909
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Ulcerated&#44; erythematous&#44; rounded&#44; nodular lesion with relatively well-defined borders on the antihelix&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "A&#46; Ortiz, P&#46; Mart&#237;n, J&#46; Dom&#237;nguez, J&#46; Conejo-Mir"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Ortiz"
            ]
            1 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Mart&#237;n"
            ]
            2 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Dom&#237;nguez"
            ]
            3 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Conejo-Mir"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731015001271"
        "doi" => "10.1016/j.ad.2015.01.014"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015001271?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015002012?idApp=UINPBA000044"
    "url" => "/15782190/0000010600000008/v1_201510011018/S1578219015002012/v1_201510011018/en/main.assets"
  ]
  "en" => array:15 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
    "titulo" => "Alopecia and Hirsutism in a Postmenopausal Woman as the Presenting Complaint of Ovarian Hilus &#40;Leydig&#41; Cell Tumor"
    "tieneTextoCompleto" => true
    "saludo" => "<span class="elsevierStyleItalic">To the Editor&#58;</span>"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "676"
        "paginaFinal" => "678"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "L&#46; Berbegal, M&#46;P&#46; Albares, F&#46;J&#46; De-Leon, G&#46; Negueruela"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "L&#46;"
            "apellidos" => "Berbegal"
            "email" => array:1 [
              0 => "lauraberbegal&#64;gmail&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "M&#46;P&#46;"
            "apellidos" => "Albares"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "F&#46;J&#46;"
            "apellidos" => "De-Leon"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "G&#46;"
            "apellidos" => "Negueruela"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital General Universitario de Alicante&#44; Alicante&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Endocrinolog&#237;a&#44; Hospital General Universitario de Alicante&#44; Alicante&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Alopecia e hirsutismo en una mujer posmenop&#225;usica como forma de presentaci&#243;n de un tumor de c&#233;lulas de Leydig hiliar del ovario"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 812
            "Ancho" => 2168
            "Tamanyo" => 330204
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A&#44; Triangular-shaped frontoparietal hairline recession&#46; B&#44; Hair thinning on the crown&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Female androgenetic alopecia is one of the main causes of hair loss&#44; and affects 50&#37; of women in their lifetime&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a> Alopecia and hirsutism as a manifestation of hyperandrogenism in postmenopausal women can have various causes&#44; ranging from normal physiological changes to an ovarian or adrenal tumor&#46; Recommended tests in any woman presenting with alopecia are a detailed clinical history&#44; physical examination&#44; general blood tests &#40;including complete blood count and thyroid stimulating hormone and ferritin levels&#41; and a hormone study with measurement of dehydroepiandrosterone sulfate and total and free testosterone levels&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">We present the case of a 65-year-old woman who presented with a 1-year history of hair loss and black facial hair&#46; There was no past history of alopecia&#44; hirsutism&#44; or hyperandrogenism&#46; Her history was remarkable for cardiovascular risk factors &#40;hypertension&#44; dyslipidemia&#44; and diabetes mellitus&#41;&#44; and she was also being monitored by the endocrinology department for euthyroid goiter&#46; The physical examination showed frontoparietal hair loss in a triangular-shaped pattern &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a> A&#41; and diffuse thinning on the crown &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a> B&#41;&#46; These findings were consistent with male-pattern female hair loss grade II in the Ebling classification system&#46; The patient also had hirsutism &#40;Ferriman-Gallwey score 9&#41;&#44; located predominantly on the face and sides of the neck but also in the chin area &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Examination of the external genitalia revealed an enlarged clitoris&#46; There were no other signs of virilization&#44; such as voice deepening or increased muscle bulk&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Considering the physical findings&#44; we requested blood tests with complete blood count&#44; biochemistry&#44; erythrocyte sedimentation rate&#44; thyroid hormones&#44; and iron profile&#46; The results were all within normal ranges&#46; A hormone study showed hyperandrogenism&#44; with elevated testosterone levels &#40;4&#46;06<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#59; normal range&#44; 0&#46;20-0&#46;80<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#41;&#46; The tests also showed a level of 28<span class="elsevierStyleHsp" style=""></span>nmol&#47;L for sex hormone binding globulin &#40;normal range&#44; 11-124<span class="elsevierStyleHsp" style=""></span>nmol&#47;L&#41; and a free testosterone index of 45 &#40;normal range&#44; 1&#46;6-6&#41;&#46; Free testosterone is the biologically active fraction of testosterone&#46; Androstenedione&#44; dehydroepiandrosterone sulfate&#44; and 17-hydroxyprogesterone levels were all within normal limits&#46; Estradiol levels were high due to peripheral aromatization of testosterone&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The results suggested an ovarian tumor and we ordered a vaginal ultrasound&#44; which revealed no alterations&#46; The patient was referred to the endocrinology department for further testing&#44; including tumor marker and imaging tests&#46; Prolactin and cortisol tests were normal&#44; as were the results for all tumor markers analyzed except carcinoembryonic antigen&#44; with a level of 14&#46;5<span class="elsevierStyleHsp" style=""></span>ng&#47;mL &#40;normal range&#44; 0-5<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#41;&#46; An abdominal computed tomography scan showed images consistent with a left adrenal tumor &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; Magnetic resonance imaging of the pelvis showed no signs of an ovarian tumor&#46; With these findings&#44; it was decided to perform a left adrenalectomy&#44; but the patient continued to show high testosterone levels &#40;4&#46;06<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#59; normal range&#44; 0&#46;20-0&#46;80&#41; and a high free testosterone index &#40;42&#46;6&#59; normal range&#44; 1&#46;6-6&#41; after the operation&#46; Finally&#44; given the strong suspicion of hyperandrogenism of ovarian origin&#44; we performed a bilateral adnexectomy&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">The histologic study confirmed a diagnosis of Leydig cell tumor&#44; hilar type&#44; in the right ovary&#46; At the time of writing&#44; 2 months after the adnexectomy&#44; the patient&#39;s testosterone levels have returned to normal and there are evident improvements in her hirsutism and alopecia&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Alopecia and hirsutism can be the presenting manifestation of a tumor&#44;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">2</span></a> as shown by the case reported herein&#46; Hilar Leydig cell tumors of the ovary are very rare and account for just 0&#46;5&#37; of all ovarian tumors&#46; Accordingly&#44; very few cases have been described in the literature&#46; Although benign&#44; these tumors frequently cause virilization&#44; with increased androgen production&#44;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">3&#8211;5</span></a> and they are also associated with an increased risk of thromboembolism&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">6</span></a> Leydig tumor cells in the ovary can be very small and may go undetected in imaging studies&#46; This is why adnexectomy is frequently performed as part of a diagnosis of exclusion&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">7</span></a> Adnexectomy of just the affected ovary is an option in premenopausal women&#46; The ovary to be removed is identified during surgery by measuring testosterone levels in the ovarian veins&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">8</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Hyperandrogenism&#44; particularly with signs of virilization&#44; is very uncommon in postmenopausal women and tends to be due to tumors &#40;mainly of ovarian or adrenal origin&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">9</span></a> Other causes that should be ruled out&#44; however&#44; are drugs&#44; pituitary disorders&#44; and the ectopic production of hormones by tumors&#46; The severity of the hyperandrogenism&#44; the patient&#39;s age&#44; and the speed with which signs and symptoms appear are all important diagnostic clues&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Berbegal L&#44; Albares MP&#44; De-Leon FJ&#44; Negueruela G&#46; Alopecia e hirsutismo en una mujer posmenop&#225;usica como forma de presentaci&#243;n de un tumor de c&#233;lulas de Leydig hiliar del ovario&#46; Actas Dermosifiliogr&#46; 2015&#59;106&#58;676&#8211;678&#46;</p>"
      ]
    ]
    "multimedia" => array:3 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 812
            "Ancho" => 2168
            "Tamanyo" => 330204
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A&#44; Triangular-shaped frontoparietal hairline recession&#46; B&#44; Hair thinning on the crown&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1171
            "Ancho" => 1660
            "Tamanyo" => 375421
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Hirsutism affecting the chin and sides of the face and neck&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 1868
            "Ancho" => 1626
            "Tamanyo" => 296322
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Left adrenal nodule measuring 2&#46;6<span class="elsevierStyleHsp" style=""></span>cm&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:9 [
            0 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Manejo de las mujeres posmenop&#225;usicas en la alopecia androgen&#233;tica"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46; Rivera"
                            1 => "A&#46; Guerra-Tapia"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2008"
                        "volumen" => "99"
                        "paginaInicial" => "257"
                        "paginaFinal" => "261"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18394400"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alertas cut&#225;neas en malignidades sist&#233;micas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46; Yuste"
                            1 => "P&#46; Unamuno"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.adengl.2012.05.026"
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2013"
                        "volumen" => "104"
                        "paginaInicial" => "543"
                        "paginaFinal" => "553"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23891448"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pure Leydig cell tumour &#40;hilus cell&#41; of the ovary&#58; A rare cause of virilization after menopause"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "G&#46; Bajocchi"
                            1 => "N&#46; Manci"
                            2 => "G&#46; Angeletti"
                            3 => "R&#46; Celleno"
                            4 => "D&#46; Fratini"
                            5 => "G&#46; Gilardi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Gynecol Obstet Invest"
                        "fecha" => "1997"
                        "volumen" => "44"
                        "paginaInicial" => "141"
                        "paginaFinal" => "144"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9286731"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Leydig cell tumor of the ovary postmenopausal woman presenting with virilization"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "I&#46; Bancos"
                            1 => "H&#46; Prawius"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "The Endocrinologist"
                        "fecha" => "2008"
                        "volumen" => "18"
                        "paginaInicial" => "146"
                        "paginaFinal" => "149"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bilateral Leydig cell tumour of the ovary&#58; A rare cause of virilization in postmenopausal patient"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "O&#46;A&#46; Sanz"
                            1 => "P&#46;R&#46; Martinez"
                            2 => "R&#46;T&#46; Guarch"
                            3 => "M&#46;J&#46; Go&#241;i"
                            4 => "J&#46;L&#46; Alcazar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.maturitas.2006.11.013"
                      "Revista" => array:6 [
                        "tituloSerie" => "Maturitas"
                        "fecha" => "2007"
                        "volumen" => "57"
                        "paginaInicial" => "214"
                        "paginaFinal" => "216"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17289310"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A Leydig cell tumor of the ovary resulting in extreme hyperandrogenism&#44; erythrocytosis&#44; and recurrent pulmonar embolism"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "P&#46; Kozan"
                            1 => "S&#46; Chalasani"
                            2 => "D&#46;J&#46; Handelsman"
                            3 => "A&#46;H&#46; Pike"
                            4 => "B&#46;A&#46; Crawford"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1210/jc.2013-3108"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Endocrinol Metab"
                        "fecha" => "2014"
                        "volumen" => "99"
                        "paginaInicial" => "12"
                        "paginaFinal" => "17"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24152686"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A rare case of hyperandrogenism&#58; Bilateral Leydig cell tumor of the ovary"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Marcelino"
                            1 => "E&#46; Nobre"
                            2 => "J&#46; Concei&#231;&#227;o"
                            3 => "L&#46; Lopes"
                            4 => "H&#46; Vilar"
                            5 => "M&#46; Fran&#231;a Martins"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Med Port"
                        "fecha" => "2010"
                        "volumen" => "23"
                        "paginaInicial" => "113"
                        "paginaFinal" => "118"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20353714"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intraoperative testosterone assay for virilizing ovarian tumor topographic assessment&#58; Report of a Leydig cell tumor of the ovary in a premenopausal woman with an adrenal incidentaloma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46; Regnier"
                            1 => "A&#46; Bennet"
                            2 => "D&#46; Malet"
                            3 => "T&#46; Guez"
                            4 => "M&#46; Plantavid"
                            5 => "P&#46; Rochaix"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Clin EndocrinolMetab"
                        "fecha" => "2002"
                        "volumen" => "87"
                        "paginaInicial" => "3074"
                        "paginaFinal" => "3077"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hiperandrogenismo avanzado en una mujer posmenop&#225;usica&#46; Caso cl&#237;nico"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "P&#46; Salman"
                            1 => "M&#46; Cuello"
                            2 => "M&#46; Kolbach"
                            3 => "R&#46; Gejman"
                            4 => "E&#46; Arteaga"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "/S0034-98872011000800013"
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Med Chile"
                        "fecha" => "2011"
                        "volumen" => "139"
                        "paginaInicial" => "1066"
                        "paginaFinal" => "1070"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22215338"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010600000008/v1_201510011018/S1578219015002024/v1_201510011018/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6157"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case and Research Letters"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010600000008/v1_201510011018/S1578219015002024/v1_201510011018/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015002024?idApp=UINPBA000044"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Case and Research Letters
Alopecia and Hirsutism in a Postmenopausal Woman as the Presenting Complaint of Ovarian Hilus (Leydig) Cell Tumor
Alopecia e hirsutismo en una mujer posmenopáusica como forma de presentación de un tumor de células de Leydig hiliar del ovario
L. Berbegala,
Corresponding author
lauraberbegal@gmail.com

Corresponding author.
, M.P. Albaresa, F.J. De-Leona, G. Negueruelab
a Servicio de Dermatología, Hospital General Universitario de Alicante, Alicante, Spain
b Servicio de Endocrinología, Hospital General Universitario de Alicante, Alicante, Spain
Read
6776
Times
was read the article
2177
Total PDF
4599
Total HTML
Share statistics
 array:24 [
  "pii" => "S1578219015002024"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2015.07.004"
  "estado" => "S300"
  "fechaPublicacion" => "2015-10-01"
  "aid" => "1145"
  "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
  "copyrightAnyo" => "2014"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "cor"
  "cita" => "Actas Dermosifiliogr. 2015;106:676-8"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 908
    "formatos" => array:3 [
      "EPUB" => 48
      "HTML" => 479
      "PDF" => 381
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0001731015001295"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2014.12.022"
      "estado" => "S300"
      "fechaPublicacion" => "2015-10-01"
      "aid" => "1145"
      "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; y AEDV"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "crp"
      "cita" => "Actas Dermosifiliogr. 2015;106:676-8"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 744
        "formatos" => array:3 [
          "EPUB" => 2
          "HTML" => 378
          "PDF" => 364
        ]
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta cient&#237;fico-cl&#237;nica</span>"
        "titulo" => "Alopecia e hirsutismo en una mujer posmenop&#225;usica como forma de presentaci&#243;n de un tumor de c&#233;lulas de Leydig hiliar del ovario"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "676"
            "paginaFinal" => "678"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Alopecia and Hirsutism in a Postmenopausal Woman as the Presenting Complaint of Ovarian Hilus &#40;Leydig&#41; Cell Tumor"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0015"
            "etiqueta" => "Figura 3"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr3.jpeg"
                "Alto" => 1120
                "Ancho" => 975
                "Tamanyo" => 161737
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">N&#243;dulo suprarrenal izquierdo de 2&#44;6<span class="elsevierStyleHsp" style=""></span>cm&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "L&#46; Berbegal, M&#46;P&#46; Albares, F&#46;J&#46; De-Leon, G&#46; Negueruela"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "L&#46;"
                "apellidos" => "Berbegal"
              ]
              1 => array:2 [
                "nombre" => "M&#46;P&#46;"
                "apellidos" => "Albares"
              ]
              2 => array:2 [
                "nombre" => "F&#46;J&#46;"
                "apellidos" => "De-Leon"
              ]
              3 => array:2 [
                "nombre" => "G&#46;"
                "apellidos" => "Negueruela"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219015002024"
          "doi" => "10.1016/j.adengl.2015.07.004"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015002024?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015001295?idApp=UINPBA000044"
      "url" => "/00017310/0000010600000008/v1_201510020746/S0001731015001295/v1_201510020746/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1578219015002036"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2015.07.005"
    "estado" => "S300"
    "fechaPublicacion" => "2015-10-01"
    "aid" => "1146"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2015;106:678-80"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 880
      "formatos" => array:3 [
        "EPUB" => 44
        "HTML" => 547
        "PDF" => 289
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
      "titulo" => "Diagnostic Value of Color Doppler Ultrasound for Cutaneous Odontogenic Sinus Tract"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "678"
          "paginaFinal" => "680"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Utilidad de la ecograf&#237;a doppler color para el diagn&#243;stico de f&#237;stulas dentocut&#225;neas"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1667
              "Ancho" => 1251
              "Tamanyo" => 381212
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Cutaneous horn sunken into the skin over the left horizontal ramus of the mandible&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "C&#46; Garrido Colmenero, G&#46; Blasco Morente, J&#46;M&#46; Latorre Fuentes, R&#46; Ruiz Villaverde"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Garrido Colmenero"
            ]
            1 => array:2 [
              "nombre" => "G&#46;"
              "apellidos" => "Blasco Morente"
            ]
            2 => array:2 [
              "nombre" => "J&#46;M&#46;"
              "apellidos" => "Latorre Fuentes"
            ]
            3 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Ruiz Villaverde"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731015001301"
        "doi" => "10.1016/j.ad.2014.12.023"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015001301?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015002036?idApp=UINPBA000044"
    "url" => "/15782190/0000010600000008/v1_201510011018/S1578219015002036/v1_201510011018/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1578219015002012"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2015.07.003"
    "estado" => "S300"
    "fechaPublicacion" => "2015-10-01"
    "aid" => "1143"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2015;106:675-6"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 976
      "formatos" => array:3 [
        "EPUB" => 41
        "HTML" => 558
        "PDF" => 377
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
      "titulo" => "Cell Phone-Induced Chondrodermatitis Nodularis Antihelicis"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "675"
          "paginaFinal" => "676"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Condrodermatitis nodular del antih&#233;lix por tel&#233;fono m&#243;vil"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1221
              "Ancho" => 1628
              "Tamanyo" => 324909
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Ulcerated&#44; erythematous&#44; rounded&#44; nodular lesion with relatively well-defined borders on the antihelix&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "A&#46; Ortiz, P&#46; Mart&#237;n, J&#46; Dom&#237;nguez, J&#46; Conejo-Mir"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Ortiz"
            ]
            1 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Mart&#237;n"
            ]
            2 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Dom&#237;nguez"
            ]
            3 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Conejo-Mir"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731015001271"
        "doi" => "10.1016/j.ad.2015.01.014"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015001271?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015002012?idApp=UINPBA000044"
    "url" => "/15782190/0000010600000008/v1_201510011018/S1578219015002012/v1_201510011018/en/main.assets"
  ]
  "en" => array:15 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
    "titulo" => "Alopecia and Hirsutism in a Postmenopausal Woman as the Presenting Complaint of Ovarian Hilus &#40;Leydig&#41; Cell Tumor"
    "tieneTextoCompleto" => true
    "saludo" => "<span class="elsevierStyleItalic">To the Editor&#58;</span>"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "676"
        "paginaFinal" => "678"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "L&#46; Berbegal, M&#46;P&#46; Albares, F&#46;J&#46; De-Leon, G&#46; Negueruela"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "L&#46;"
            "apellidos" => "Berbegal"
            "email" => array:1 [
              0 => "lauraberbegal&#64;gmail&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "M&#46;P&#46;"
            "apellidos" => "Albares"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "F&#46;J&#46;"
            "apellidos" => "De-Leon"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "G&#46;"
            "apellidos" => "Negueruela"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital General Universitario de Alicante&#44; Alicante&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Endocrinolog&#237;a&#44; Hospital General Universitario de Alicante&#44; Alicante&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Alopecia e hirsutismo en una mujer posmenop&#225;usica como forma de presentaci&#243;n de un tumor de c&#233;lulas de Leydig hiliar del ovario"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 812
            "Ancho" => 2168
            "Tamanyo" => 330204
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A&#44; Triangular-shaped frontoparietal hairline recession&#46; B&#44; Hair thinning on the crown&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Female androgenetic alopecia is one of the main causes of hair loss&#44; and affects 50&#37; of women in their lifetime&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a> Alopecia and hirsutism as a manifestation of hyperandrogenism in postmenopausal women can have various causes&#44; ranging from normal physiological changes to an ovarian or adrenal tumor&#46; Recommended tests in any woman presenting with alopecia are a detailed clinical history&#44; physical examination&#44; general blood tests &#40;including complete blood count and thyroid stimulating hormone and ferritin levels&#41; and a hormone study with measurement of dehydroepiandrosterone sulfate and total and free testosterone levels&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">We present the case of a 65-year-old woman who presented with a 1-year history of hair loss and black facial hair&#46; There was no past history of alopecia&#44; hirsutism&#44; or hyperandrogenism&#46; Her history was remarkable for cardiovascular risk factors &#40;hypertension&#44; dyslipidemia&#44; and diabetes mellitus&#41;&#44; and she was also being monitored by the endocrinology department for euthyroid goiter&#46; The physical examination showed frontoparietal hair loss in a triangular-shaped pattern &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a> A&#41; and diffuse thinning on the crown &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a> B&#41;&#46; These findings were consistent with male-pattern female hair loss grade II in the Ebling classification system&#46; The patient also had hirsutism &#40;Ferriman-Gallwey score 9&#41;&#44; located predominantly on the face and sides of the neck but also in the chin area &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Examination of the external genitalia revealed an enlarged clitoris&#46; There were no other signs of virilization&#44; such as voice deepening or increased muscle bulk&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Considering the physical findings&#44; we requested blood tests with complete blood count&#44; biochemistry&#44; erythrocyte sedimentation rate&#44; thyroid hormones&#44; and iron profile&#46; The results were all within normal ranges&#46; A hormone study showed hyperandrogenism&#44; with elevated testosterone levels &#40;4&#46;06<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#59; normal range&#44; 0&#46;20-0&#46;80<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#41;&#46; The tests also showed a level of 28<span class="elsevierStyleHsp" style=""></span>nmol&#47;L for sex hormone binding globulin &#40;normal range&#44; 11-124<span class="elsevierStyleHsp" style=""></span>nmol&#47;L&#41; and a free testosterone index of 45 &#40;normal range&#44; 1&#46;6-6&#41;&#46; Free testosterone is the biologically active fraction of testosterone&#46; Androstenedione&#44; dehydroepiandrosterone sulfate&#44; and 17-hydroxyprogesterone levels were all within normal limits&#46; Estradiol levels were high due to peripheral aromatization of testosterone&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The results suggested an ovarian tumor and we ordered a vaginal ultrasound&#44; which revealed no alterations&#46; The patient was referred to the endocrinology department for further testing&#44; including tumor marker and imaging tests&#46; Prolactin and cortisol tests were normal&#44; as were the results for all tumor markers analyzed except carcinoembryonic antigen&#44; with a level of 14&#46;5<span class="elsevierStyleHsp" style=""></span>ng&#47;mL &#40;normal range&#44; 0-5<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#41;&#46; An abdominal computed tomography scan showed images consistent with a left adrenal tumor &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; Magnetic resonance imaging of the pelvis showed no signs of an ovarian tumor&#46; With these findings&#44; it was decided to perform a left adrenalectomy&#44; but the patient continued to show high testosterone levels &#40;4&#46;06<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#59; normal range&#44; 0&#46;20-0&#46;80&#41; and a high free testosterone index &#40;42&#46;6&#59; normal range&#44; 1&#46;6-6&#41; after the operation&#46; Finally&#44; given the strong suspicion of hyperandrogenism of ovarian origin&#44; we performed a bilateral adnexectomy&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">The histologic study confirmed a diagnosis of Leydig cell tumor&#44; hilar type&#44; in the right ovary&#46; At the time of writing&#44; 2 months after the adnexectomy&#44; the patient&#39;s testosterone levels have returned to normal and there are evident improvements in her hirsutism and alopecia&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Alopecia and hirsutism can be the presenting manifestation of a tumor&#44;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">2</span></a> as shown by the case reported herein&#46; Hilar Leydig cell tumors of the ovary are very rare and account for just 0&#46;5&#37; of all ovarian tumors&#46; Accordingly&#44; very few cases have been described in the literature&#46; Although benign&#44; these tumors frequently cause virilization&#44; with increased androgen production&#44;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">3&#8211;5</span></a> and they are also associated with an increased risk of thromboembolism&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">6</span></a> Leydig tumor cells in the ovary can be very small and may go undetected in imaging studies&#46; This is why adnexectomy is frequently performed as part of a diagnosis of exclusion&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">7</span></a> Adnexectomy of just the affected ovary is an option in premenopausal women&#46; The ovary to be removed is identified during surgery by measuring testosterone levels in the ovarian veins&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">8</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Hyperandrogenism&#44; particularly with signs of virilization&#44; is very uncommon in postmenopausal women and tends to be due to tumors &#40;mainly of ovarian or adrenal origin&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">9</span></a> Other causes that should be ruled out&#44; however&#44; are drugs&#44; pituitary disorders&#44; and the ectopic production of hormones by tumors&#46; The severity of the hyperandrogenism&#44; the patient&#39;s age&#44; and the speed with which signs and symptoms appear are all important diagnostic clues&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Berbegal L&#44; Albares MP&#44; De-Leon FJ&#44; Negueruela G&#46; Alopecia e hirsutismo en una mujer posmenop&#225;usica como forma de presentaci&#243;n de un tumor de c&#233;lulas de Leydig hiliar del ovario&#46; Actas Dermosifiliogr&#46; 2015&#59;106&#58;676&#8211;678&#46;</p>"
      ]
    ]
    "multimedia" => array:3 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 812
            "Ancho" => 2168
            "Tamanyo" => 330204
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A&#44; Triangular-shaped frontoparietal hairline recession&#46; B&#44; Hair thinning on the crown&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1171
            "Ancho" => 1660
            "Tamanyo" => 375421
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Hirsutism affecting the chin and sides of the face and neck&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 1868
            "Ancho" => 1626
            "Tamanyo" => 296322
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Left adrenal nodule measuring 2&#46;6<span class="elsevierStyleHsp" style=""></span>cm&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:9 [
            0 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Manejo de las mujeres posmenop&#225;usicas en la alopecia androgen&#233;tica"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46; Rivera"
                            1 => "A&#46; Guerra-Tapia"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2008"
                        "volumen" => "99"
                        "paginaInicial" => "257"
                        "paginaFinal" => "261"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18394400"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alertas cut&#225;neas en malignidades sist&#233;micas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46; Yuste"
                            1 => "P&#46; Unamuno"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.adengl.2012.05.026"
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2013"
                        "volumen" => "104"
                        "paginaInicial" => "543"
                        "paginaFinal" => "553"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23891448"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pure Leydig cell tumour &#40;hilus cell&#41; of the ovary&#58; A rare cause of virilization after menopause"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "G&#46; Bajocchi"
                            1 => "N&#46; Manci"
                            2 => "G&#46; Angeletti"
                            3 => "R&#46; Celleno"
                            4 => "D&#46; Fratini"
                            5 => "G&#46; Gilardi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Gynecol Obstet Invest"
                        "fecha" => "1997"
                        "volumen" => "44"
                        "paginaInicial" => "141"
                        "paginaFinal" => "144"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9286731"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Leydig cell tumor of the ovary postmenopausal woman presenting with virilization"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "I&#46; Bancos"
                            1 => "H&#46; Prawius"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "The Endocrinologist"
                        "fecha" => "2008"
                        "volumen" => "18"
                        "paginaInicial" => "146"
                        "paginaFinal" => "149"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bilateral Leydig cell tumour of the ovary&#58; A rare cause of virilization in postmenopausal patient"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "O&#46;A&#46; Sanz"
                            1 => "P&#46;R&#46; Martinez"
                            2 => "R&#46;T&#46; Guarch"
                            3 => "M&#46;J&#46; Go&#241;i"
                            4 => "J&#46;L&#46; Alcazar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.maturitas.2006.11.013"
                      "Revista" => array:6 [
                        "tituloSerie" => "Maturitas"
                        "fecha" => "2007"
                        "volumen" => "57"
                        "paginaInicial" => "214"
                        "paginaFinal" => "216"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17289310"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A Leydig cell tumor of the ovary resulting in extreme hyperandrogenism&#44; erythrocytosis&#44; and recurrent pulmonar embolism"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "P&#46; Kozan"
                            1 => "S&#46; Chalasani"
                            2 => "D&#46;J&#46; Handelsman"
                            3 => "A&#46;H&#46; Pike"
                            4 => "B&#46;A&#46; Crawford"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1210/jc.2013-3108"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Endocrinol Metab"
                        "fecha" => "2014"
                        "volumen" => "99"
                        "paginaInicial" => "12"
                        "paginaFinal" => "17"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24152686"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A rare case of hyperandrogenism&#58; Bilateral Leydig cell tumor of the ovary"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Marcelino"
                            1 => "E&#46; Nobre"
                            2 => "J&#46; Concei&#231;&#227;o"
                            3 => "L&#46; Lopes"
                            4 => "H&#46; Vilar"
                            5 => "M&#46; Fran&#231;a Martins"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Med Port"
                        "fecha" => "2010"
                        "volumen" => "23"
                        "paginaInicial" => "113"
                        "paginaFinal" => "118"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20353714"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intraoperative testosterone assay for virilizing ovarian tumor topographic assessment&#58; Report of a Leydig cell tumor of the ovary in a premenopausal woman with an adrenal incidentaloma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46; Regnier"
                            1 => "A&#46; Bennet"
                            2 => "D&#46; Malet"
                            3 => "T&#46; Guez"
                            4 => "M&#46; Plantavid"
                            5 => "P&#46; Rochaix"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Clin EndocrinolMetab"
                        "fecha" => "2002"
                        "volumen" => "87"
                        "paginaInicial" => "3074"
                        "paginaFinal" => "3077"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hiperandrogenismo avanzado en una mujer posmenop&#225;usica&#46; Caso cl&#237;nico"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "P&#46; Salman"
                            1 => "M&#46; Cuello"
                            2 => "M&#46; Kolbach"
                            3 => "R&#46; Gejman"
                            4 => "E&#46; Arteaga"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "/S0034-98872011000800013"
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Med Chile"
                        "fecha" => "2011"
                        "volumen" => "139"
                        "paginaInicial" => "1066"
                        "paginaFinal" => "1070"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22215338"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010600000008/v1_201510011018/S1578219015002024/v1_201510011018/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6157"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case and Research Letters"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010600000008/v1_201510011018/S1578219015002024/v1_201510011018/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015002024?idApp=UINPBA000044"
]
Article information
ISSN: 15782190
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 10 8 18
2024 October 122 59 181
2024 September 126 49 175
2024 August 152 64 216
2024 July 129 57 186
2024 June 152 32 184
2024 May 144 53 197
2024 April 109 34 143
2024 March 110 36 146
2024 February 87 37 124
2024 January 67 35 102
2023 December 106 20 126
2023 November 82 35 117
2023 October 59 15 74
2023 September 88 30 118
2023 August 67 22 89
2023 July 83 30 113
2023 June 79 25 104
2023 May 100 23 123
2023 April 69 18 87
2023 March 80 20 100
2023 February 84 22 106
2023 January 62 21 83
2022 December 76 46 122
2022 November 41 26 67
2022 October 42 26 68
2022 September 40 33 73
2022 August 30 33 63
2022 July 28 43 71
2022 June 34 25 59
2022 May 37 29 66
2022 April 298 39 337
2022 March 328 53 381
2022 February 63 30 93
2022 January 65 48 113
2021 December 52 36 88
2021 November 55 60 115
2021 October 59 59 118
2021 September 65 40 105
2021 August 52 29 81
2021 July 34 34 68
2021 June 24 24 48
2021 May 37 28 65
2021 April 46 41 87
2021 March 65 25 90
2021 February 53 23 76
2021 January 30 19 49
2020 December 31 19 50
2020 November 20 14 34
2020 October 31 8 39
2020 September 44 13 57
2020 August 20 24 44
2020 July 17 18 35
2020 June 36 44 80
2020 May 27 19 46
2020 April 34 21 55
2020 March 37 21 58
2020 February 4 1 5
2020 January 6 2 8
2019 December 8 0 8
2019 November 4 0 4
2019 October 0 5 5
2019 September 6 4 10
2019 August 4 2 6
2019 July 4 9 13
2019 June 4 20 24
2019 May 6 32 38
2019 April 5 22 27
2019 March 4 26 30
2019 February 3 29 32
2019 January 13 11 24
2018 December 8 7 15
2018 November 11 0 11
2018 October 13 0 13
2018 September 4 1 5
2018 August 0 5 5
2018 July 0 8 8
2018 June 0 1 1
2018 May 0 10 10
2018 April 0 2 2
2018 March 0 2 2
2018 February 26 4 30
2018 January 27 7 34
2017 December 33 9 42
2017 November 20 3 23
2017 October 28 7 35
2017 September 23 9 32
2017 August 23 5 28
2017 July 15 8 23
2017 June 25 15 40
2017 May 22 9 31
2017 April 16 8 24
2017 March 5 26 31
2017 February 19 7 26
2017 January 8 4 12
2016 December 22 14 36
2016 November 30 23 53
2016 October 27 21 48
2016 September 0 1 1
2016 July 2 1 3
2016 June 3 0 3
2016 January 0 1 1
2015 November 0 1 1
Show all

Follow this link to access the full text of the article

Idiomas
Actas Dermo-Sifiliográficas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?