Identifying Randomized Clinical Trials in Spanish-Language Dermatology Journals

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"apellidos" => "Bonfill" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "c" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Grupo de Investigación Dermatológica (GRID), Universidad de Antioquía, Medellín, Colombia" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Centro Cochrane Iberoamericano, Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau), Barcelona, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Centro Cochrane Iberoamericano, Institutd’InvestigacióBiomèdicaSant Pau (IIB Sant Pau), CIBER Epidemiología y Salud Pública (CIBERESP), Universitat Autònoma de Barcelona, Barcelona, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Identificación de ensayos clínicos en revistas dermatológicas publicadas en español" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1014 "Ancho" => 1704 "Tamanyo" => 84324 ] ] "descripcion" => array:1 [ "en" => "Number of randomized clinical trials published in 5-year periods." ] ] ] "textoCompleto" => "IntroductionAn individual clinician's experience is an important source of knowledge in dermatology. However, when such knowledge becomes the sole basis for clinical decision-making, therapeutic effects are often overestimated. Compounding this problem is the physician's tendency to rely on knowledge acquired during residency training or to find it difficult to incorporate current evidence into routine practice, especially if new information calls beliefs and previous experience into question.<a class="elsevierStyleCrossRefs" href="#bib0125">1–3</a> Clinical trials follow an experimental design in which a researcher manipulates exposure to 1 or more treatments in order to compare effects.<a class="elsevierStyleCrossRefs" href="#bib0140">4,5</a> The main purpose of this type of study is to assess the efficacy and safety of an intervention that seeks to prevent or cure a health condition or to speed recovery.<a class="elsevierStyleCrossRefs" href="#bib0140">4,5</a>Given the importance of randomized clinical trials (RCTs), it might be supposed that they would be easily available to both treating physicians and researchers. Problems arise, however, when health care professionals seek to locate and use information from RCTs. Among the difficulties that have been reported are 1) the novelty of the terminology itself, 2) the underuse of descriptors when trials are indexed in databases, and 3) the high percentage of journals that do not post articles online.<a class="elsevierStyleCrossRefs" href="#bib0150">6–8</a> Problems that further interfere with physicians’ use of RCTs are lack of time for reading these articles and the lack of access to the publishing journals.<a class="elsevierStyleCrossRefs" href="#bib0165">9,10</a>To help identify RCTs published in the Spanish language in several medical specialties, the Cochrane Collaboration undertook a project to search for them manually. Searching in databases alone reportedly fails to find a significant number of RCTs in the specialties of ophthalmology, public health, anesthesiology and critical care, and general and internal medicine.<a class="elsevierStyleCrossRefs" href="#bib0160">8,11–14</a> In addition, online MEDLINE searches can fail to return up to 25% of RCTs available, mainly when the authors have not included the search terms randomized controlled trial or controlled clinical trial in the titles.<a class="elsevierStyleCrossRef" href="#bib0195">15</a>We present the results for dermatology journals included in the Cochrane Collaboration's project on hand searching for RCTs in Spanish, as these findings complement the important earlier work of González-Castro et al.<a class="elsevierStyleCrossRefs" href="#bib0155">7,16</a> in identifying trials reported in Actas Dermo-Sifiliográficas between 1948 and 2000 and Medicina Cutánea Ibero-Latino-Americana between 1970 and 2000.Aim of This StudyWe sought to exhaustively and rigorously search for RCTs in dermatology journals published in the Spanish language.Material and MethodsIdentification of JournalsWe identified journals within the framework of a project led by the Iberoamerican Cochrane Centre (IbCC) in Barcelona, Spain, to find biomedical journals in countries where Spanish is spoken. An IbCC-trained researcher, who was responsible for managing and coordinating the study, carried out the journal search and sent the results to the IbCC collaborators in each country. The collaborators were charged with confirming that the journal information was complete and accurate. Any other sources that might help us find these journals, such as national library catalogs and collections, were also searched.Appropriate databases (IBECS [the Spanish health sciences index], EMBASE [Excerpta Médica dataBASE], and IMBIOMED) and the web pages of dermatology associations in Latin American countries where Spanish is spoken were included in the search. We also made direct contact with journals’ editorial boards and specialists in dermatology, and as a last resort we searched for candidate journals in Google.Journals were eligible if they published original research articles and made full texts available to researchers in print or online. Journals were excluded if they focused on pediatric dermatology, covered areas already included in the project under another specialty (for example, infectious diseases), or published only reviews or case reports in dermatology. If a journal's full texts could not be obtained by any means, it was likewise excluded.Each journal was searched in reverse chronological order from 2012 to the first issue published (provided full texts were still available). If no RCTs were found for 5 consecutive years, the manual search was halted, unless we had ready access to issues, in which case we extended the search.Additionally, we checked whether these journals instructed authors to follow the CONSORT (Consolidated Standards of Reporting Trials) guidelines and whether they were indexed in MEDLINE or EMBASE.Hand Search MethodWe asked 40 undergraduate and postgraduate students in the health sciences to carry out the systematic hand searches. Each student did a test search of a journal for a period the IbCC had already assessed. The searchers’ training was based on the IbCC's hand RCT search protocol for Spanish articles (available from <a href="http://www.cochrane.es/~cochrane/?q=es/node/140">http://www.cochrane.es/∼cochrane/?q=es/node/140</a>). That protocol was based on the Cochrane Collaboration's Training Manual for Handsearchers.Once training and the pilot search had been completed, the searcher was assigned volumes in which to find RCTs by 1) reading the tables of contents, 2) locating key terms for RCT-associated concepts in Spanish (aleatorizado, prospectivo, comparación, etc.) in titles and abstracts, and 3) reading the patients and methods sections of the full texts. Afterwards, the searcher filled in the form for recording the results of hand searches of journals or updates.Electronic Search MethodSo that we could compare electronic and hand-searching results, we conducted RCT searches in MEDLINE (through PubMED), EMBASE, LILACS (Latin American index of scientific and technical literature) and IBECS. Validated combinations of descriptors were used in multiterm combinations, along with free-text terms.<a class="elsevierStyleCrossRefs" href="#bib0125">1,2</a> (See Appendix 1, online supplementary material.) These searches were updated in November 2014 to check for RCTs published between 2012 and 2014.RCT Inclusion CriteriaWe followed the Cochrane Collaboration criteria for defining RCTs. Thus, we included 1) trials comparing treatments in humans; 2) trials designed to gather data prospectively; 3) clinical comparisons of 2 or more interventions (1 of which could be a control treatment) of any type (medications, operations, diagnostic or educational procedures, rehabilitation therapies, management systems, or other); and 4) trials using random, or quasi-random, assignment of treatments, and/or use of double blinding. The randomization units could be individuals, clusters (hospitals, communities), or parts of the body (such as split faces or different limbs).Classification of Information and Identification of RCTsEach searcher recorded the number of RCTs found while reading the assigned issues. Later, 2 evaluators who had formal training in clinical epidemiology (G. S. and H. P.) read the full texts in order to confirm that each RCT met the selection criteria.Planned AnalysisDescriptive statistics were compiled. Continuous variables were summarized in appropriate measures. Qualitative variables were reported as absolute and relative frequencies and percentages. Data were stored in a spreadsheet (Excel, version 2010, Microsoft Office, Redmond, WA, USA). SPSS software (IBM, version 19 (Armonk, NY, USA) was used to analyze the data.ResultsThe only dermatology journal we found to be indexed in both MEDLINE and EMBASE at this time is Actas Dermo-Sifiliográficas. The journals indexed only in EMBASE are Dermatología Revista Mexicana, Revista Argentina de Dermatología, Medicina Cutánea Ibero-Latino-Americana, and Piel.Included and Excluded JournalsOf the 28 candidate journals, 21 were included. All 28 journals and the reasons for exclusions are shown in <a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>.<elsevierMultimedia ident="fig0005"></elsevierMultimedia>Actas Dermo-Sifiliográficas is the only journal included in this study that specifies and promotes the use of the CONSORT guidelines.<a class="elsevierStyleCrossRef" href="#bib0205">17</a>RCTs IdentifiedA total of 144 RCTs published since 1969 were found in the 21 included journals (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). Seventy-eight (54%) of the RCTs were published in the 16 Latin American journals searched, and 66 (46%) were found in the 5 Spanish journals (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>, which also shows the number of RCTs found in each journal). A large number of the RCTs found in Actas Dermo-Sifiliográficas and Medicina Cutánea Ibero-Latino-Americana were previously gathered and described in 2 earlier publications.<a class="elsevierStyleCrossRefs" href="#bib0155">7,16</a><elsevierMultimedia ident="tbl0005"></elsevierMultimedia>Analysis by 5-year intervals shows that many of the RCTs (89 in total) were published in the last 20 years (from 1993 to 2012). The 25 preceding years (from 1992 to 1968) saw 55 RCTs published (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>).<elsevierMultimedia ident="fig0010"></elsevierMultimedia>The most frequently studied skin diseases in the Spanish trials were psoriasis (11 RCTs), mycoses (9), and acne vulgaris (8). The most frequent disease contexts in the Latin American trials were common warts (9 RCTs), mycoses (8), acne vulgaris (7), and lower-limb ulcers (6). Details of the RCTs found are listed in Appendix 2 of the online supplementary material.The MEDLINE search identified 3997 entries, 669 of which were in Actas Dermo-Sifilográficas. Two of these entries were initially considered candidates for inclusion, but were not in fact RCTs, and 4 were. These 4 articles included the word randomized in their indexed title. All these RCTs had also been found by hand searching (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>).<elsevierMultimedia ident="fig0015"></elsevierMultimedia>The EMBASE search initially yielded 9584 entries (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>); 16 of these were for RCTs. Of these, 6 had been previously identified by hand searching and 2 were newly identified ones from the Dermatología Revista Mexicana. These 2 articles had not been found during earlier hand searching because neither print nor digital versions of the table of contents could be found for issue 6 of volume 56 or issue 2 of volume 48 (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>).The search of indexes on the Spanish language Virtual Health Library (BVS) initially returned 5140 entries (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). After filtering for dermatology, 30 candidates were identified; 2 of these were not RCTs. Thus, the digital searches found only 28 (19.5%) of the 144 RCTs that had already been found by hand searching (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>).We were unable to hand search all of the following journals because of missing volumes or issues: Dermatología Revista Mexicana, Dermatología Venezolana, Revista Argentina de Dermatología, Archivos Argentinos de Dermatología, the 2 Ecuadoran journals, the single journal published in the Dominican Republic, and Revista Fontilles (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>).DiscussionRCTs are the principal units of analysis for systematic reviews, clinical practice guidelines, and other documents that synthesize knowledge. Regulatory agencies also require them before medicines can be approved for use in humans.Hand searching identified about 80% more RCTs than database searching. This finding is consistent with previous reports for our own field, in which journals like Archives of Dermatology<a class="elsevierStyleCrossRef" href="#bib0210">18</a> and Actas Dermo-Sifiliográficas<a class="elsevierStyleCrossRefs" href="#bib0155">7,19</a> were searched. It is also consistent with reports for other medical specialties.<a class="elsevierStyleCrossRef" href="#bib0160">8</a> These results underline the importance of manually checking dermatology journals, as many of the RCTs we found could not have been otherwise identified, possibly because MEDLINE and EMBASE are not sensitive to search terms in Spanish.<a class="elsevierStyleCrossRefs" href="#bib0175">11,19–22</a> Alternatively, the reason may be that Actas Dermo-Sifiliográficas is the only Spanish language dermatology journal indexed in MEDLINE or that EMBASE does not index all of the other Spanish journals. Compounding the problem is the inherent difficulty of electronic searching in any language other than English. Searches in other languages have returned 37% fewer entries than searches in English.<a class="elsevierStyleCrossRef" href="#bib0195">15</a>Dermatología Revista Mexicana and Dermatología Venezolana were the Latin American journals that published the largest number of RCTs. In Spain, Actas Dermo-Sifilográficas published the most. We offer no explanation for these observations, but we think it may be that more funding is available for conducting RCTs in the countries where these journals are published. It is also possible that these journals have less stringent policies governing the RCTs they publish than other Latin American journals do.Our findings showed an increase in the number of RCTs published in Spanish in recent decades. The reason for the increase may lie in the importance currently placed on evidence-based medicine, an approach that obliges researchers to value this type of study above others because it provides more and stronger evidence.We found 78 Spanish-language RCTs in Latin American journals and 66 in Spanish ones published over the course of 44 years. On average, RCTs were published at a rate of 1 to 2 per year, a statistic that is in sharp contrast with the rate of RCT publication in English. Up to 11 RCTs per year are published by Archives of Dermatology alone, for example.<a class="elsevierStyleCrossRef" href="#bib0210">18</a>The CONSORT reporting guidelines were established in 1996 to standardize the way clinical trials are reported in different journals.<a class="elsevierStyleCrossRef" href="#bib0205">17</a> These standards indirectly encourage greater methodological rigor by obliging the researcher to describe the design explicitly and fully. Only 1 journal in this study, namely Actas Dermo-Sifilográficas, requires authors to follow the CONSORT guidelines. There seems to be a need, therefore, not only to promote the design of RCTs but also to encourage journals to require CONSORT-guided reporting, just as the important English-language dermatology journals do.That both Spanish and Latin American researchers showed interest in psoriasis, mycoses, and acne was noteworthy. The attention is probably attributable to the greater impact of these diseases among patients, given that clinical importance would drive an effort to identify effective therapies; alternatively, the pharmaceutical industry may be more interested in funding RCTs in these areas.<a class="elsevierStyleCrossRefs" href="#bib0235">23,24</a>This study identified Spanish-language dermatology journals. Their full texts proved impossible to find in only a few cases once we applied various means to locate them. This experience underlines the importance of posting full texts online because this strategy not only facilitates the identification of RCTs for systematic reviews but also contributes to making knowledge available worldwide and enhancing the visibility of Spanish-language publications.One of the strengths of this study is the large number of journals, volumes, and issues we searched exhaustively and systematically. A total of 28 dermatology journals were initially identified. Electronic searching found nearly all the RCTs that had been identified manually. Two references were found by database searching but not by hand searching, since print copies of the issues in question were unavailable. A limitation of our study is our lack of access to all of the articles published from the start of publication (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). However, those early issues probably did not contain RCTs, since this design was little used before the 1970s. Another limitation is that we excluded relevant RCTs that were published in journals that focus on other specialties or in dermatology journals published in other languages. Furthermore, we did not evaluate the quality of the RCTs for this report, although we have recently been working on that task and plan to publish the results shortly.In conclusion, manual searches identified a large number of RCTs in dermatology journals in Spain and Latin America. However, these journals publish far fewer RCTs than English-language dermatology journals do. Finally, ready access to these RCTs and a large number of other articles of interest is still lacking.Ethical DisclosuresProtection of human and animal subjectsThe authors declare that no experiments were performed on humans or animals for this investigation.Data confidentialityThe authors declare that no private patient data are disclosed in this article.Right to privacy and informed consentThe authors declare that no private patient data are disclosed in this article.FundingGroup of Investigative Dermatology (GRID), Medical Faculty, Universidad de Antioquía, Medellín, Colombia.Conflicts of InterestThe authors declare that they have no conflicts of interest." "textoCompletoSecciones" => array:1 [ "secciones" => array:14 [ 0 => array:3 [ "identificador" => "xres520382" "titulo" => "Abstract" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Background" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Objective" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Methods" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Results" ] 4 => array:2 [ "identificador" => "abst0025" "titulo" => "Conclusions" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec540939" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres520383" "titulo" => "Resumen" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "abst0030" "titulo" => "Introducción" ] 1 => array:2 [ "identificador" => "abst0035" "titulo" => "Objetivo" ] 2 => array:2 [ "identificador" => "abst0040" "titulo" => "Métodos" ] 3 => array:2 [ "identificador" => "abst0045" "titulo" => "Resultados" ] 4 => array:2 [ "identificador" => "abst0050" "titulo" => "Conclusiones" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec540938" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Aim of This Study" ] 6 => array:3 [ "identificador" => "sec0015" "titulo" => "Material and Methods" "secciones" => array:6 [ 0 => array:2 [ "identificador" => "sec0020" "titulo" => "Identification of Journals" ] 1 => array:2 [ "identificador" => "sec0025" "titulo" => "Hand Search Method" ] 2 => array:2 [ "identificador" => "sec0030" "titulo" => "Electronic Search Method" ] 3 => array:2 [ "identificador" => "sec0035" "titulo" => "RCT Inclusion Criteria" ] 4 => array:2 [ "identificador" => "sec0040" "titulo" => "Classification of Information and Identification of RCTs" ] 5 => array:2 [ "identificador" => "sec0045" "titulo" => "Planned Analysis" ] ] ] 7 => array:3 [ "identificador" => "sec0050" "titulo" => "Results" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0055" "titulo" => "Included and Excluded Journals" ] 1 => array:2 [ "identificador" => "sec0060" "titulo" => "RCTs Identified" ] ] ] 8 => array:2 [ "identificador" => "sec0065" "titulo" => "Discussion" ] 9 => array:3 [ "identificador" => "sec0070" "titulo" => "Ethical Disclosures" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0075" "titulo" => "Protection of human and animal subjects" ] 1 => array:2 [ "identificador" => "sec0080" "titulo" => "Data confidentiality" ] 2 => array:2 [ "identificador" => "sec0085" "titulo" => "Right to privacy and informed consent" ] ] ] 10 => array:2 [ "identificador" => "sec0090" "titulo" => "Funding" ] 11 => array:2 [ "identificador" => "sec0095" "titulo" => "Conflicts of Interest" ] 12 => array:2 [ "identificador" => "xack178205" "titulo" => "Acknowledgments" ] 13 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2014-08-08" "fechaAceptado" => "2015-01-25" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec540939" "palabras" => array:3 [ 0 => "Randomized clinical trial" 1 => "Manual literature search" 2 => "Dermatology journals" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec540938" "palabras" => array:3 [ 0 => "Ensayo clínico aleatorizado" 1 => "Búsqueda manual" 2 => "Revistas dermatológicas" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "BackgroundThe necessary foundation for good clinical practice lies in knowledge derived from clinical research. Evidence from randomized clinical trials (RCTs) is the pillar on which decisions about therapy are based. ObjectiveTo search exhaustively and rigorously to identify RCTs in dermatology journals published in Spanish. MethodsWe located dermatology journals through the following search engines and indexes: PubMed, LILACS, SciELO, Periódica, Latindex, Índice Médico Español, C-17, IBECS, EMBASE, and IMBIOMED. We also sought information through dermatology associations and dermatologists in countries where Spanish was the usual language of publication, and we searched the Internet (Google). Afterwards we searched the journals electronically and manually to identify RCTs in all available volumes and issues, checking from the year publication started through 2012. ResultsOf 28 journals identified, we included 21 in the search. We found a total of 144 RCTs published since 1969; 78 (54%) were in Latin American journals and 66 (46%) were in Spanish journals. The most frequent disease contexts for RCTs in Spanish journals were psoriasis, mycoses, and acne vulgaris. In Latin American journals, the most frequent disease contexts were common warts, mycoses, acne vulgaris, and skin ulcers on the lower limbs. Manual searches identified more RCTs than electronic searches. ConclusionsManual searches found a larger number of RCTs. Relatively fewer RCTs are published in Spanish and Latin American journals than in English-language journals. Internet facilitated access to full texts published by many journals; however, free open access to these texts is still unavailable and a large number of journal issues are still not posted online." "secciones" => array:5 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Background" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Objective" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Methods" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Results" ] 4 => array:2 [ "identificador" => "abst0025" "titulo" => "Conclusions" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "IntroducciónPara asegurar una práctica adecuada se hace necesario incorporar el conocimiento derivado de la investigación clínica, en la que los ensayos clínicos con asignación aleatoria (ECA) son el pilar fundamental para la decisión de una terapia. ObjetivoBuscar e identificar de manera exhaustiva y rigurosa los ECA publicados en revistas dermatológicas en español. MétodosSe detectaron las revistas dermatológicas mediante búsquedas en PubMed, LILACS, SciELO, Periódica; Latindex; Índice Médico Español; el C-17; el IBECS, EMBASE e IMBIOMED; y/o por el contacto con las asociaciones de dermatología/especialistas de cada país y la búsqueda libre por Google. Posteriormente se realizó tanto una búsqueda manual como electrónica de los ECA en los volúmenes y números disponibles. La revisión de cada revista se realizó en cada volumen y número desde su publicación hasta el año 2012. ResultadosDe las 28 revistas encontradas se incluyeron 21. Desde 1969 se identificaron 144 ECA, 54% (78) en las revistas latinoamericanas y 46% (66) en las españolas. Entre las enfermedades estudiadas predomina la psoriasis, las micosis y el acné vulgar entre las revistas españolas, mientras que entre las latinoamericanas prevalecen las verrugas vulgares, las micosis, el acné vulgar y las úlceras de los miembros inferiores. La búsqueda manual identificó más ECA de los detectados por búsqueda electrónica. ConclusionesLa búsqueda manual permitió una alta detección de ECA. El número de ECA identificados en revistas dermatológicas iberolatinoamericanas es bajo comparado con las revistas publicadas en inglés. Internet facilitó el acceso al texto completo de muchas revistas, pero se carece aún de un acceso libre al texto completo y de un volumen importante de números publicados por esta vía." "secciones" => array:5 [ 0 => array:2 [ "identificador" => "abst0030" "titulo" => "Introducción" ] 1 => array:2 [ "identificador" => "abst0035" "titulo" => "Objetivo" ] 2 => array:2 [ "identificador" => "abst0040" "titulo" => "Métodos" ] 3 => array:2 [ "identificador" => "abst0045" "titulo" => "Resultados" ] 4 => array:2 [ "identificador" => "abst0050" "titulo" => "Conclusiones" ] ] ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "Please cite this article as: Sanclemente G, Pardo H, Sánchez S, Bonfill X. Identificación de ensayos clínicos en revistas dermatológicas publicadas en español. Actas Dermosifiliogr. 2015;106:415–422." ] ] "apendice" => array:1 [ 0 => array:1 [ "seccion" => array:1 [ 0 => array:4 [ "apendice" => "<elsevierMultimedia ident="upi0005"></elsevierMultimedia>" "etiqueta" => "Appendix A" "titulo" => "Supplementary data" "identificador" => "sec0105" ] ] ] ] "multimedia" => array:5 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 3056 "Ancho" => 2657 "Tamanyo" => 455940 ] ] "descripcion" => array:1 [ "en" => "Flow chart of the dermatology journal search process and the selection of included and excluded journals." ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1014 "Ancho" => 1704 "Tamanyo" => 84324 ] ] "descripcion" => array:1 [ "en" => "Number of randomized clinical trials published in 5-year periods." ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1660 "Ancho" => 2785 "Tamanyo" => 268146 ] ] "descripcion" => array:1 [ "en" => "Flow chart of the digital search process for each database searched and the selection of randomized clinical trials (RCTs). BVS refers to the Biblioteca Virtual de la Salud (Virtual Health Library)." ] ] 3 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:3 [ "leyenda" => "Abbreviation: RCT, randomized clinical trial." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">No. \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Journal Name \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Period Searched \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">First Year of Publication \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Periods Not Searched<a class="elsevierStyleCrossRef" href="#tblfn0005">a</a> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">No. of RCTs Found \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " colspan="5" align="left" valign="top">Latin America</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Dermatología Revista Mexicana \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1981–2012 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1956 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1969–1980, 1984, 1987 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">21 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Dermatología Venezolana \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1984–2012 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1957 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1969–1983 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">13 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Dermatología Peruana \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1996–2012 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1996 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">9 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Revista Asociación Colombiana de Dermatología \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1991–2012 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1991 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">8 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Revista Chilena de Dermatología \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1985–2012 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1985 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">8 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Dermatología Cosmética, Médica y Quirúrgica \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2003–2012 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2003 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">4 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Revista del Centro Dermatológico Pascua \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1999–2012 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1999 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">4 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Revista Argentina de Dermatología \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1981–2012 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1908 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1969–1980 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">4 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Folia Dermatológica Peruana \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1986–2012 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1986 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Dermatología Argentina \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1995–2012 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1995 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">11 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Folia Dermatológica Cubana \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2007–2012 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2007 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">12 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Archivos Argentinos de Dermatología \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1983–2012 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1951 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1969–1982 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">13 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Actas de Dermatología y Dermatopatología \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2001–2009 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2001 (publication ceased in 2009) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">14 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Revista Dominicana de Dermatología \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2010–2012 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1971 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1971–2009 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">15 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Revista Sociedad Ecuatoriana de Dermatología \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2003–2010 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1991 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1991–2002, 2005, 2008, 2009, 2011, 2012 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">16 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Gaceta Dermatológica Ecuatoriana \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1998 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1998 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1997–2012 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="5" align="left" valign="top">Total RCTs in Latin American journals</td><td class="td" title="table-entry " align="left" valign="top">78 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Spain \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">17 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Actas Dermo-Sifiliográficas \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1969–2012 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1909 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">30 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">18 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Medicina Cutánea Ibero-Latino-Americana \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1969–2012 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1966 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">25 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">19 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Piel \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1986–2012 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1986 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">10 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Actualidad Dermatológica \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1974–2008 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1962 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1969–1973, \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">21 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Revista Fontilles \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2008–2012 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1932 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1969–2002 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="5" align="left" valign="top">Total RCTs in Spanish journals</td><td class="td" title="table-entry " align="left" valign="top">66 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab840234.png" ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "a" "nota" => "These years could not be searched because neither 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We acknowledge with thanks the students enrolled in the public health master's degree program at the Universitat Autónoma de Barcelona (Victoria Alcaraz, Adrià Aguilar, Albert Barba, Ares Burballa Tarrega, Xavier Blasco, Paula Calvo, Josep Anton Cordero, Leticia de Mattos Arruda, Georgina Doria, Bàrbara Gascons, Claudia Herrera, Conxita Jiménez, Ekaterina Karseladze, Gemma Mas Dalmau, Antonio Melendez, Bernat Mir, Neus Muñoz, Mireia Pardas, Katrin-Steffanie Rappe, Gemma Robleda Font, Juan Rojas, Farre Sanjuan, Francesc Sansa, Sergi Segarra, Amalia Sillero, Ainhoa Simon, Elisabeth Tasa, Monica Tolsanas, Diana Tundidor, Maitane Turrillas, Francisco Ramon Villanueva, and Mariano Yumaysla Hernandez. We also thank Omar Gandarilla (Research Fellow, gastroenterology division, Beth Israel Deaconess Medical Center) and Oscar Zazueta (visiting professor, Universidad Autónoma de Baja California and teaching assistant, Harvard Medical School) for their help with identifying Latin American journals. We thank Dr Gabriel Palenque Campero (of the Sociedad Boliviana de Dermatología) for his interest in the study and help. Others whose help we gratefully acknowledge are Ana Laura Grigera, secretary of the Colegio Iberolatinoamericano de Dermatología; Elizabeth Dussan and Nelly Pinzón of the Asociación Colombiana de Dermatología; Karina Vielma and Dra María Isabel Herane of the Sociedad Chilena de Dermatología; Pedro Molinero, Graciela Ponzoni, and Dra Esther Roe Crespo of Hospital de la Santa Creu i Sant Pau; Drs Roberto Arenas and Jorge Ocampo-Candiani of Revista Dermatología Cosmética Médica y Quirúrgica, and Dr Alexandro Bonifaz for his help in locating and sending journal volumes or full texts of the articles we requested. In addition, we express special gratitude to Ivan Solà of the Iberoamerican Cochrane Centre for his critical reading of the manuscript and advice on searches and to Paola Andrea Ramírez (librarian) for her help with some of the search terms for online searches." "vista" => "all" ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010600000005/v1_201506041458/S1578219015000980/v1_201506041458/en/main.assets" "Apartado" => array:4 [ "identificador" => "6155" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original Articles" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010600000005/v1_201506041458/S1578219015000980/v1_201506041458/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015000980?idApp=UINPBA000044"]

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Original Article

Identifying Randomized Clinical Trials in Spanish-Language Dermatology Journals

Identificación de ensayos clínicos en revistas dermatológicas publicadas en español

G. Sanclementea,

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sanclementegloria@gmail.com

Corresponding author.

, H. Pardob, S. Sáncheza, X. Bonfillc

a Grupo de Investigación Dermatológica (GRID), Universidad de Antioquía, Medellín, Colombia

b Centro Cochrane Iberoamericano, Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau), Barcelona, Spain

c Centro Cochrane Iberoamericano, Institutd’InvestigacióBiomèdicaSant Pau (IIB Sant Pau), CIBER Epidemiología y Salud Pública (CIBERESP), Universitat Autònoma de Barcelona, Barcelona, Spain

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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">An individual clinician&#39;s experience is an important source of knowledge in dermatology&#46; However&#44; when such knowledge becomes the sole basis for clinical decision-making&#44; therapeutic effects are often overestimated&#46; Compounding this problem is the physician&#39;s tendency to rely on knowledge acquired during residency training or to find it difficult to incorporate current evidence into routine practice&#44; especially if new information calls beliefs and previous experience into question&#46;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">1&#8211;3</span></a> Clinical trials follow an experimental design in which a researcher manipulates exposure to 1 or more treatments in order to compare effects&#46;<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">4&#44;5</span></a> The main purpose of this type of study is to assess the efficacy and safety of an intervention that seeks to prevent or cure a health condition or to speed recovery&#46;<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">4&#44;5</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Given the importance of randomized clinical trials &#40;RCTs&#41;&#44; it might be supposed that they would be easily available to both treating physicians and researchers&#46; Problems arise&#44; however&#44; when health care professionals seek to locate and use information from RCTs&#46; Among the difficulties that have been reported are 1&#41; the novelty of the terminology itself&#44; 2&#41; the underuse of descriptors when trials are indexed in databases&#44; and 3&#41; the high percentage of journals that do not post articles online&#46;<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">6&#8211;8</span></a> Problems that further interfere with physicians&#8217; use of RCTs are lack of time for reading these articles and the lack of access to the publishing journals&#46;<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">9&#44;10</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">To help identify RCTs published in the Spanish language in several medical specialties&#44; the Cochrane Collaboration undertook a project to search for them manually&#46; Searching in databases alone reportedly fails to find a significant number of RCTs in the specialties of ophthalmology&#44; public health&#44; anesthesiology and critical care&#44; and general and internal medicine&#46;<a class="elsevierStyleCrossRefs" href="#bib0160"><span class="elsevierStyleSup">8&#44;11&#8211;14</span></a> In addition&#44; online MEDLINE searches can fail to return up to 25&#37; of RCTs available&#44; mainly when the authors have not included the search terms <span class="elsevierStyleItalic">randomized controlled trial</span> or <span class="elsevierStyleItalic">controlled clinical trial</span> in the titles&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">15</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">We present the results for dermatology journals included in the Cochrane Collaboration&#39;s project on hand searching for RCTs in Spanish&#44; as these findings complement the important earlier work of Gonz&#225;lez-Castro et al&#46;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">7&#44;16</span></a> in identifying trials reported in <span class="elsevierStyleItalic">Actas Dermo-Sifiliogr&#225;ficas</span> between 1948 and 2000 and <span class="elsevierStyleItalic">Medicina Cut&#225;nea Ibero-Latino-Americana</span> between 1970 and 2000&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Aim of This Study</span><p id="par0025" class="elsevierStylePara elsevierViewall">We sought to exhaustively and rigorously search for RCTs in dermatology journals published in the Spanish language&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Material and Methods</span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Identification of Journals</span><p id="par0030" class="elsevierStylePara elsevierViewall">We identified journals within the framework of a project led by the Iberoamerican Cochrane Centre &#40;IbCC&#41; in Barcelona&#44; Spain&#44; to find biomedical journals in countries where Spanish is spoken&#46; An IbCC-trained researcher&#44; who was responsible for managing and coordinating the study&#44; carried out the journal search and sent the results to the IbCC collaborators in each country&#46; The collaborators were charged with confirming that the journal information was complete and accurate&#46; Any other sources that might help us find these journals&#44; such as national library catalogs and collections&#44; were also searched&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Appropriate databases &#40;IBECS &#91;the Spanish health sciences index&#93;&#44; EMBASE &#91;Excerpta M&#233;dica dataBASE&#93;&#44; and IMBIOMED&#41; and the web pages of dermatology associations in Latin American countries where Spanish is spoken were included in the search&#46; We also made direct contact with journals&#8217; editorial boards and specialists in dermatology&#44; and as a last resort we searched for candidate journals in Google&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Journals were eligible if they published original research articles and made full texts available to researchers in print or online&#46; Journals were excluded if they focused on pediatric dermatology&#44; covered areas already included in the project under another specialty &#40;for example&#44; infectious diseases&#41;&#44; or published only reviews or case reports in dermatology&#46; If a journal&#39;s full texts could not be obtained by any means&#44; it was likewise excluded&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Each journal was searched in reverse chronological order from 2012 to the first issue published &#40;provided full texts were still available&#41;&#46; If no RCTs were found for 5 consecutive years&#44; the manual search was halted&#44; unless we had ready access to issues&#44; in which case we extended the search&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Additionally&#44; we checked whether these journals instructed authors to follow the CONSORT &#40;Consolidated Standards of Reporting Trials&#41; guidelines and whether they were indexed in MEDLINE or EMBASE&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Hand Search Method</span><p id="par0055" class="elsevierStylePara elsevierViewall">We asked 40 undergraduate and postgraduate students in the health sciences to carry out the systematic hand searches&#46; Each student did a test search of a journal for a period the IbCC had already assessed&#46; The searchers&#8217; training was based on the IbCC&#39;s hand RCT search protocol for Spanish articles &#40;available from <a href="http://www.cochrane.es/~cochrane/?q=es/node/140">http&#58;&#47;&#47;www&#46;cochrane&#46;es&#47;&#8764;cochrane&#47;&#63;q&#61;es&#47;node&#47;140</a>&#41;&#46; That protocol was based on the Cochrane Collaboration&#39;s <span class="elsevierStyleItalic">Training Manual for Handsearchers</span>&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Once training and the pilot search had been completed&#44; the searcher was assigned volumes in which to find RCTs by 1&#41; reading the tables of contents&#44; 2&#41; locating key terms for RCT-associated concepts in Spanish &#40;<span class="elsevierStyleItalic">aleatorizado&#44; prospectivo&#44; comparaci&#243;n</span>&#44; etc&#46;&#41; in titles and abstracts&#44; and 3&#41; reading the patients and methods sections of the full texts&#46; Afterwards&#44; the searcher filled in the form for recording the results of hand searches of journals or updates&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Electronic Search Method</span><p id="par0065" class="elsevierStylePara elsevierViewall">So that we could compare electronic and hand-searching results&#44; we conducted RCT searches in MEDLINE &#40;through PubMED&#41;&#44; EMBASE&#44; LILACS &#40;Latin American index of scientific and technical literature&#41; and IBECS&#46; Validated combinations of descriptors were used in multiterm combinations&#44; along with free-text terms&#46;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">1&#44;2</span></a> &#40;See Appendix 1&#44; online supplementary material&#46;&#41; These searches were updated in November 2014 to check for RCTs published between 2012 and 2014&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">RCT Inclusion Criteria</span><p id="par0070" class="elsevierStylePara elsevierViewall">We followed the Cochrane Collaboration criteria for defining RCTs&#46; Thus&#44; we included 1&#41; trials comparing treatments in humans&#59; 2&#41; trials designed to gather data prospectively&#59; 3&#41; clinical comparisons of 2 or more interventions &#40;1 of which could be a control treatment&#41; of any type &#40;medications&#44; operations&#44; diagnostic or educational procedures&#44; rehabilitation therapies&#44; management systems&#44; or other&#41;&#59; and 4&#41; trials using random&#44; or quasi-random&#44; assignment of treatments&#44; and&#47;or use of double blinding&#46; The randomization units could be individuals&#44; clusters &#40;hospitals&#44; communities&#41;&#44; or parts of the body &#40;such as split faces or different limbs&#41;&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Classification of Information and Identification of RCTs</span><p id="par0075" class="elsevierStylePara elsevierViewall">Each searcher recorded the number of RCTs found while reading the assigned issues&#46; Later&#44; 2 evaluators who had formal training in clinical epidemiology &#40;G&#46; S&#46; and H&#46; P&#46;&#41; read the full texts in order to confirm that each RCT met the selection criteria&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Planned Analysis</span><p id="par0080" class="elsevierStylePara elsevierViewall">Descriptive statistics were compiled&#46; Continuous variables were summarized in appropriate measures&#46; Qualitative variables were reported as absolute and relative frequencies and percentages&#46; Data were stored in a spreadsheet &#40;Excel&#44; version 2010&#44; Microsoft Office&#44; Redmond&#44; WA&#44; USA&#41;&#46; SPSS software &#40;IBM&#44; version 19 &#40;Armonk&#44; NY&#44; USA&#41; was used to analyze the data&#46;</p></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Results</span><p id="par0085" class="elsevierStylePara elsevierViewall">The only dermatology journal we found to be indexed in both MEDLINE and EMBASE at this time is <span class="elsevierStyleItalic">Actas Dermo-Sifiliogr&#225;ficas</span>&#46; The journals indexed only in EMBASE are <span class="elsevierStyleItalic">Dermatolog&#237;a Revista Mexicana</span>&#44; <span class="elsevierStyleItalic">Revista Argentina de Dermatolog&#237;a</span>&#44; <span class="elsevierStyleItalic">Medicina Cut&#225;nea Ibero-Latino-Americana</span>&#44; and <span class="elsevierStyleItalic">Piel</span>&#46;</p><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Included and Excluded Journals</span><p id="par0090" class="elsevierStylePara elsevierViewall">Of the 28 candidate journals&#44; 21 were included&#46; All 28 journals and the reasons for exclusions are shown in <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0095" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Actas Dermo-Sifiliogr&#225;ficas</span> is the only journal included in this study that specifies and promotes the use of the CONSORT guidelines&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">17</span></a></p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">RCTs Identified</span><p id="par0100" class="elsevierStylePara elsevierViewall">A total of 144 RCTs published since 1969 were found in the 21 included journals &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; Seventy-eight &#40;54&#37;&#41; of the RCTs were published in the 16 Latin American journals searched&#44; and 66 &#40;46&#37;&#41; were found in the 5 Spanish journals &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#44; which also shows the number of RCTs found in each journal&#41;&#46; A large number of the RCTs found in <span class="elsevierStyleItalic">Actas Dermo-Sifiliogr&#225;ficas</span> and <span class="elsevierStyleItalic">Medicina Cut&#225;nea Ibero-Latino-Americana</span> were previously gathered and described in 2 earlier publications&#46;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">7&#44;16</span></a></p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0105" class="elsevierStylePara elsevierViewall">Analysis by 5-year intervals shows that many of the RCTs &#40;89 in total&#41; were published in the last 20 years &#40;from 1993 to 2012&#41;&#46; The 25 preceding years &#40;from 1992 to 1968&#41; saw 55 RCTs published &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0110" class="elsevierStylePara elsevierViewall">The most frequently studied skin diseases in the Spanish trials were psoriasis &#40;11 RCTs&#41;&#44; mycoses &#40;9&#41;&#44; and acne vulgaris &#40;8&#41;&#46; The most frequent disease contexts in the Latin American trials were common warts &#40;9 RCTs&#41;&#44; mycoses &#40;8&#41;&#44; acne vulgaris &#40;7&#41;&#44; and lower-limb ulcers &#40;6&#41;&#46; Details of the RCTs found are listed in Appendix 2 of the online supplementary material&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">The MEDLINE search identified 3997 entries&#44; 669 of which were in <span class="elsevierStyleItalic">Actas Dermo-Sifilogr&#225;ficas</span>&#46; Two of these entries were initially considered candidates for inclusion&#44; but were not in fact RCTs&#44; and 4 were&#46; These 4 articles included the word <span class="elsevierStyleItalic">randomized</span> in their indexed title&#46; All these RCTs had also been found by hand searching &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0120" class="elsevierStylePara elsevierViewall">The EMBASE search initially yielded 9584 entries &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#59; 16 of these were for RCTs&#46; Of these&#44; 6 had been previously identified by hand searching and 2 were newly identified ones from the <span class="elsevierStyleItalic">Dermatolog&#237;a Revista Mexicana</span>&#46; These 2 articles had not been found during earlier hand searching because neither print nor digital versions of the table of contents could be found for issue 6 of volume 56 or issue 2 of volume 48 &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">The search of indexes on the Spanish language Virtual Health Library &#40;BVS&#41; initially returned 5140 entries &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; After filtering for dermatology&#44; 30 candidates were identified&#59; 2 of these were not RCTs&#46; Thus&#44; the digital searches found only 28 &#40;19&#46;5&#37;&#41; of the 144 RCTs that had already been found by hand searching &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">We were unable to hand search all of the following journals because of missing volumes or issues&#58; <span class="elsevierStyleItalic">Dermatolog&#237;a Revista Mexicana</span>&#44; <span class="elsevierStyleItalic">Dermatolog&#237;a Venezolana</span>&#44; <span class="elsevierStyleItalic">Revista Argentina de Dermatolog&#237;a</span>&#44; <span class="elsevierStyleItalic">Archivos Argentinos de Dermatolog&#237;a</span>&#44; the 2 Ecuadoran journals&#44; the single journal published in the Dominican Republic&#44; and <span class="elsevierStyleItalic">Revista Fontilles</span> &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p></span></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Discussion</span><p id="par0135" class="elsevierStylePara elsevierViewall">RCTs are the principal units of analysis for systematic reviews&#44; clinical practice guidelines&#44; and other documents that synthesize knowledge&#46; Regulatory agencies also require them before medicines can be approved for use in humans&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Hand searching identified about 80&#37; more RCTs than database searching&#46; This finding is consistent with previous reports for our own field&#44; in which journals like <span class="elsevierStyleItalic">Archives of Dermatology</span><a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">18</span></a> and <span class="elsevierStyleItalic">Actas Dermo</span>-<span class="elsevierStyleItalic">Sifiliogr&#225;ficas</span><a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">7&#44;19</span></a> were searched&#46; It is also consistent with reports for other medical specialties&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">8</span></a> These results underline the importance of manually checking dermatology journals&#44; as many of the RCTs we found could not have been otherwise identified&#44; possibly because MEDLINE and EMBASE are not sensitive to search terms in Spanish&#46;<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">11&#44;19&#8211;22</span></a> Alternatively&#44; the reason may be that <span class="elsevierStyleItalic">Actas Dermo-Sifiliogr&#225;ficas</span> is the only Spanish language dermatology journal indexed in MEDLINE or that EMBASE does not index all of the other Spanish journals&#46; Compounding the problem is the inherent difficulty of electronic searching in any language other than English&#46; Searches in other languages have returned 37&#37; fewer entries than searches in English&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">15</span></a></p><p id="par0145" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Dermatolog&#237;a Revista Mexicana</span> and <span class="elsevierStyleItalic">Dermatolog&#237;a Venezolana</span> were the Latin American journals that published the largest number of RCTs&#46; In Spain&#44; <span class="elsevierStyleItalic">Actas Dermo-Sifilogr&#225;ficas</span> published the most&#46; We offer no explanation for these observations&#44; but we think it may be that more funding is available for conducting RCTs in the countries where these journals are published&#46; It is also possible that these journals have less stringent policies governing the RCTs they publish than other Latin American journals do&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">Our findings showed an increase in the number of RCTs published in Spanish in recent decades&#46; The reason for the increase may lie in the importance currently placed on evidence-based medicine&#44; an approach that obliges researchers to value this type of study above others because it provides more and stronger evidence&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">We found 78 Spanish-language RCTs in Latin American journals and 66 in Spanish ones published over the course of 44 years&#46; On average&#44; RCTs were published at a rate of 1 to 2 per year&#44; a statistic that is in sharp contrast with the rate of RCT publication in English&#46; Up to 11 RCTs per year are published by <span class="elsevierStyleItalic">Archives of Dermatology</span> alone&#44; for example&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">18</span></a></p><p id="par0160" class="elsevierStylePara elsevierViewall">The CONSORT reporting guidelines were established in 1996 to standardize the way clinical trials are reported in different journals&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">17</span></a> These standards indirectly encourage greater methodological rigor by obliging the researcher to describe the design explicitly and fully&#46; Only 1 journal in this study&#44; namely <span class="elsevierStyleItalic">Actas Dermo-Sifilogr&#225;ficas</span>&#44; requires authors to follow the CONSORT guidelines&#46; There seems to be a need&#44; therefore&#44; not only to promote the design of RCTs but also to encourage journals to require CONSORT-guided reporting&#44; just as the important English-language dermatology journals do&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">That both Spanish and Latin American researchers showed interest in psoriasis&#44; mycoses&#44; and acne was noteworthy&#46; The attention is probably attributable to the greater impact of these diseases among patients&#44; given that clinical importance would drive an effort to identify effective therapies&#59; alternatively&#44; the pharmaceutical industry may be more interested in funding RCTs in these areas&#46;<a class="elsevierStyleCrossRefs" href="#bib0235"><span class="elsevierStyleSup">23&#44;24</span></a></p><p id="par0170" class="elsevierStylePara elsevierViewall">This study identified Spanish-language dermatology journals&#46; Their full texts proved impossible to find in only a few cases once we applied various means to locate them&#46; This experience underlines the importance of posting full texts online because this strategy not only facilitates the identification of RCTs for systematic reviews but also contributes to making knowledge available worldwide and enhancing the visibility of Spanish-language publications&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">One of the strengths of this study is the large number of journals&#44; volumes&#44; and issues we searched exhaustively and systematically&#46; A total of 28 dermatology journals were initially identified&#46; Electronic searching found nearly all the RCTs that had been identified manually&#46; Two references were found by database searching but not by hand searching&#44; since print copies of the issues in question were unavailable&#46; A limitation of our study is our lack of access to all of the articles published from the start of publication &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; However&#44; those early issues probably did not contain RCTs&#44; since this design was little used before the 1970s&#46; Another limitation is that we excluded relevant RCTs that were published in journals that focus on other specialties or in dermatology journals published in other languages&#46; Furthermore&#44; we did not evaluate the quality of the RCTs for this report&#44; although we have recently been working on that task and plan to publish the results shortly&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">In conclusion&#44; manual searches identified a large number of RCTs in dermatology journals in Spain and Latin America&#46; However&#44; these journals publish far fewer RCTs than English-language dermatology journals do&#46; Finally&#44; ready access to these RCTs and a large number of other articles of interest is still lacking&#46;</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Ethical Disclosures</span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0145">Protection of human and animal subjects</span><p id="par0185" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this investigation&#46;</p></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0150">Data confidentiality</span><p id="par0190" class="elsevierStylePara elsevierViewall">The authors declare that no private patient data are disclosed in this article&#46;</p></span><span id="sec0085" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0155">Right to privacy and informed consent</span><p id="par0195" class="elsevierStylePara elsevierViewall">The authors declare that no private patient data are disclosed in this article&#46;</p></span></span><span id="sec0090" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0160">Funding</span><p id="par0200" class="elsevierStylePara elsevierViewall">Group of Investigative Dermatology &#40;GRID&#41;&#44; Medical Faculty&#44; Universidad de Antioqu&#237;a&#44; Medell&#237;n&#44; Colombia&#46;</p></span><span id="sec0095" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0165">Conflicts of Interest</span><p id="par0205" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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    "fechaAceptado" => "2015-01-25"
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          "clase" => "keyword"
          "titulo" => "Palabras clave"
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            2 => "Revistas dermatol&#243;gicas"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Background</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The necessary foundation for good clinical practice lies in knowledge derived from clinical research&#46; Evidence from randomized clinical trials &#40;RCTs&#41; is the pillar on which decisions about therapy are based&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objective</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To search exhaustively and rigorously to identify RCTs in dermatology journals published in Spanish&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">We located dermatology journals through the following search engines and indexes&#58; PubMed&#44; LILACS&#44; SciELO&#44; Peri&#243;dica&#44; Latindex&#44; &#205;ndice M&#233;dico Espa&#241;ol&#44; C-17&#44; IBECS&#44; EMBASE&#44; and IMBIOMED&#46; We also sought information through dermatology associations and dermatologists in countries where Spanish was the usual language of publication&#44; and we searched the Internet &#40;Google&#41;&#46; Afterwards we searched the journals electronically and manually to identify RCTs in all available volumes and issues&#44; checking from the year publication started through 2012&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Of 28 journals identified&#44; we included 21 in the search&#46; We found a total of 144 RCTs published since 1969&#59; 78 &#40;54&#37;&#41; were in Latin American journals and 66 &#40;46&#37;&#41; were in Spanish journals&#46; The most frequent disease contexts for RCTs in Spanish journals were psoriasis&#44; mycoses&#44; and acne vulgaris&#46; In Latin American journals&#44; the most frequent disease contexts were common warts&#44; mycoses&#44; acne vulgaris&#44; and skin ulcers on the lower limbs&#46; Manual searches identified more RCTs than electronic searches&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Manual searches found a larger number of RCTs&#46; Relatively fewer RCTs are published in Spanish and Latin American journals than in English-language journals&#46; Internet facilitated access to full texts published by many journals&#59; however&#44; free open access to these texts is still unavailable and a large number of journal issues are still not posted online&#46;</p></span>"
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        "resumen" => "<span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Introducci&#243;n</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Para asegurar una pr&#225;ctica adecuada se hace necesario incorporar el conocimiento derivado de la investigaci&#243;n cl&#237;nica&#44; en la que los ensayos cl&#237;nicos con asignaci&#243;n aleatoria &#40;ECA&#41; son el pilar fundamental para la decisi&#243;n de una terapia&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Objetivo</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Buscar e identificar de manera exhaustiva y rigurosa los ECA publicados en revistas dermatol&#243;gicas en espa&#241;ol&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">M&#233;todos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Se detectaron las revistas dermatol&#243;gicas mediante b&#250;squedas en PubMed&#44; LILACS&#44; SciELO&#44; Peri&#243;dica&#59; Latindex&#59; &#205;ndice M&#233;dico Espa&#241;ol&#59; el C-17&#59; el IBECS&#44; EMBASE e IMBIOMED&#59; y&#47;o por el contacto con las asociaciones de dermatolog&#237;a&#47;especialistas de cada pa&#237;s y la b&#250;squeda libre por Google&#46; Posteriormente se realiz&#243; tanto una b&#250;squeda manual como electr&#243;nica de los ECA en los vol&#250;menes y n&#250;meros disponibles&#46; La revisi&#243;n de cada revista se realiz&#243; en cada volumen y n&#250;mero desde su publicaci&#243;n hasta el a&#241;o 2012&#46;</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">De las 28 revistas encontradas se incluyeron 21&#46; Desde 1969 se identificaron 144 ECA&#44; 54&#37; &#40;78&#41; en las revistas latinoamericanas y 46&#37; &#40;66&#41; en las espa&#241;olas&#46; Entre las enfermedades estudiadas predomina la psoriasis&#44; las micosis y el acn&#233; vulgar entre las revistas espa&#241;olas&#44; mientras que entre las latinoamericanas prevalecen las verrugas vulgares&#44; las micosis&#44; el acn&#233; vulgar y las &#250;lceras de los miembros inferiores&#46; La b&#250;squeda manual identific&#243; m&#225;s ECA de los detectados por b&#250;squeda electr&#243;nica&#46;</p></span> <span id="abst0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conclusiones</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">La b&#250;squeda manual permiti&#243; una alta detecci&#243;n de ECA&#46; El n&#250;mero de ECA identificados en revistas dermatol&#243;gicas iberolatinoamericanas es bajo comparado con las revistas publicadas en ingl&#233;s&#46; Internet facilit&#243; el acceso al texto completo de muchas revistas&#44; pero se carece a&#250;n de un acceso libre al texto completo y de un volumen importante de n&#250;meros publicados por esta v&#237;a&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Please cite this article as&#58; Sanclemente G&#44; Pardo H&#44; S&#225;nchez S&#44; Bonfill X&#46; Identificaci&#243;n de ensayos cl&#237;nicos en revistas dermatol&#243;gicas publicadas en espa&#241;ol&#46; Actas Dermosifiliogr&#46; 2015&#59;106&#58;415&#8211;422&#46;</p>"
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          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Flow chart of the dermatology journal search process and the selection of included and excluded journals&#46;</p>"
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        "tipo" => "MULTIMEDIAFIGURA"
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          "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Flow chart of the digital search process for each database searched and the selection of randomized clinical trials &#40;RCTs&#41;&#46; BVS refers to the Biblioteca Virtual de la Salud &#40;Virtual Health Library&#41;&#46;</p>"
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                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">No&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Journal Name&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Period Searched&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">First Year of Publication&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Periods Not Searched<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">No&#46; of RCTs Found&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " colspan="5" align="left" valign="top"><span class="elsevierStyleBold">Latin America</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Dermatolog&#237;a Revista Mexicana</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1981&#8211;2012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1956&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1969&#8211;1980&#44; 1984&#44; 1987&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Dermatolog&#237;a Venezolana</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1984&#8211;2012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1957&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1969&#8211;1983&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Dermatolog&#237;a Peruana</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1996&#8211;2012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1996&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Revista Asociaci&#243;n Colombiana de Dermatolog&#237;a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1991&#8211;2012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1991&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Revista Chilena de Dermatolog&#237;a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1985&#8211;2012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1985&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Dermatolog&#237;a Cosm&#233;tica&#44; M&#233;dica y Quir&#250;rgica</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2003&#8211;2012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2003&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Revista del Centro Dermatol&#243;gico Pascua</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1999&#8211;2012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1999&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Revista Argentina de Dermatolog&#237;a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1981&#8211;2012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1908&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1969&#8211;1980&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Folia Dermatol&#243;gica Peruana</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1986&#8211;2012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1986&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Dermatolog&#237;a Argentina</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1995&#8211;2012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1995&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Folia Dermatol&#243;gica Cubana</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2007&#8211;2012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2007&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Archivos Argentinos de Dermatolog&#237;a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1983&#8211;2012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1951&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1969&#8211;1982&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Actas de Dermatolog&#237;a y Dermatopatolog&#237;a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2001&#8211;2009&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2001 &#40;publication ceased in 2009&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Revista Dominicana de Dermatolog&#237;a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2010&#8211;2012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1971&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1971&#8211;2009&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Revista Sociedad Ecuatoriana de Dermatolog&#237;a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2003&#8211;2010&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1991&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1991&#8211;2002&#44; 2005&#44; 2008&#44; 2009&#44; 2011&#44; 2012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Gaceta Dermatol&#243;gica Ecuatoriana</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1998&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1998&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1997&#8211;2012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="5" align="left" valign="top"><span class="elsevierStyleBold">Total RCTs in Latin American journals</span></td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">78</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">Spain</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Actas Dermo-Sifiliogr&#225;ficas</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1969&#8211;2012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1909&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Medicina Cut&#225;nea Ibero-Latino-Americana</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1969&#8211;2012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1966&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Piel</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1986&#8211;2012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1986&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Actualidad Dermatol&#243;gica</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1974&#8211;2008&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1962&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1969&#8211;1973&#44;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Revista Fontilles</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2008&#8211;2012&nbsp;\t\t\t\t\t\t\n
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        "titulo" => "Acknowledgments"
        "texto" => "<p id="par0210" class="elsevierStylePara elsevierViewall">Dr Gloria Sanclemente is a PhD candidate in the department of pediatrics&#44; obstetrics&#44; gynecology&#44; and preventive medicine of the Universitat Aut&#243;noma de Barcelona&#44; Spain&#46; This study was carried out with the help of the Group of Investigative Dermatology &#40;GRID&#41; of the Universidad de Antioqu&#237;a&#44; Medell&#237;n&#44; Colombia&#46;</p> <p id="par0215" class="elsevierStylePara elsevierViewall">We acknowledge with thanks the students enrolled in the public health master&#39;s degree program at the Universitat Aut&#243;noma de Barcelona &#40;Victoria Alcaraz&#44; Adri&#224; Aguilar&#44; Albert Barba&#44; Ares Burballa Tarrega&#44; Xavier Blasco&#44; Paula Calvo&#44; Josep Anton Cordero&#44; Leticia de Mattos Arruda&#44; Georgina Doria&#44; B&#224;rbara Gascons&#44; Claudia Herrera&#44; Conxita Jim&#233;nez&#44; Ekaterina Karseladze&#44; Gemma Mas Dalmau&#44; Antonio Melendez&#44; Bernat Mir&#44; Neus Mu&#241;oz&#44; Mireia Pardas&#44; Katrin-Steffanie Rappe&#44; Gemma Robleda Font&#44; Juan Rojas&#44; Farre Sanjuan&#44; Francesc Sansa&#44; Sergi Segarra&#44; Amalia Sillero&#44; Ainhoa Simon&#44; Elisabeth Tasa&#44; Monica Tolsanas&#44; Diana Tundidor&#44; Maitane Turrillas&#44; Francisco Ramon Villanueva&#44; and Mariano Yumaysla Hernandez&#46; We also thank Omar Gandarilla &#40;Research Fellow&#44; gastroenterology division&#44; Beth Israel Deaconess Medical Center&#41; and Oscar Zazueta &#40;visiting professor&#44; Universidad Aut&#243;noma de Baja California and teaching assistant&#44; Harvard Medical School&#41; for their help with identifying Latin American journals&#46; We thank Dr Gabriel Palenque Campero &#40;of the Sociedad Boliviana de Dermatolog&#237;a&#41; for his interest in the study and help&#46; Others whose help we gratefully acknowledge are Ana Laura Grigera&#44; secretary of the Colegio Iberolatinoamericano de Dermatolog&#237;a&#59; Elizabeth Dussan and Nelly Pinz&#243;n of the Asociaci&#243;n Colombiana de Dermatolog&#237;a&#59; Karina Vielma and Dra Mar&#237;a Isabel Herane of the Sociedad Chilena de Dermatolog&#237;a&#59; Pedro Molinero&#44; Graciela Ponzoni&#44; and Dra Esther Roe Crespo of Hospital de la Santa Creu i Sant Pau&#59; Drs Roberto Arenas and Jorge Ocampo-Candiani of <span class="elsevierStyleItalic">Revista Dermatolog&#237;a Cosm&#233;tica M&#233;dica y Quir&#250;rgica</span>&#44; and Dr Alexandro Bonifaz for his help in locating and sending journal volumes or full texts of the articles we requested&#46;</p> <p id="par0220" class="elsevierStylePara elsevierViewall">In addition&#44; we express special gratitude to Ivan Sol&#224; of the Iberoamerican Cochrane Centre for his critical reading of the manuscript and advice on searches and to Paola Andrea Ram&#237;rez &#40;librarian&#41; for her help with some of the search terms for online searches&#46;</p>"
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Article information

ISSN: 15782190
Original language: English

DOI:10.1016/j.adengl.2015.04.010

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