Opinion Article
Research Unit of the Spanish Academy of Dermatology and Venerology Foundation
La unidad de investigación de la Fundación Academia Española de Dermatología y Venereología
I. García-Doval
Unidad de investigación, Fundación Academia Española de Dermatología y Venereología, Madrid, Spain
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The thermal damage to the dermis induces fibroblast activation (1), with the resulting formation of neocollagen, along with elimination of telangiectasias and pigmented lesions (2 and 3).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A.J. González-Rodríguez, R. Lorente-Gual" "autores" => array:2 [ 0 => array:2 [ "nombre" => "A.J." "apellidos" => "González-Rodríguez" ] 1 => array:2 [ "nombre" => "R." "apellidos" => "Lorente-Gual" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731014004578" "doi" => "10.1016/j.ad.2014.10.004" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731014004578?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157821901500089X?idApp=UINPBA000044" "url" => "/15782190/0000010600000005/v1_201506041458/S157821901500089X/v1_201506041458/en/main.assets" ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Opinion Article</span>" "titulo" => "Research Unit of the Spanish Academy of Dermatology and Venerology Foundation" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "346" "paginaFinal" => "349" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "I. García-Doval" "autores" => array:1 [ 0 => array:3 [ "nombre" => "I." "apellidos" => "García-Doval" "email" => array:1 [ 0 => "investigacion@aedv.es" ] ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Unidad de investigación, Fundación Academia Española de Dermatología y Venereología, Madrid, Spain" "identificador" => "aff0005" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "La unidad de investigación de la Fundación Academia Española de Dermatología y Venereología" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Many dermatologists are interested in clinical research. In a survey carried out as part of the project to create a strategic plan for the Spanish Academy of Dermatology and Venereology (AEDV), academy members identified the following as priority challenges: increasing the prestige of dermatology and dermatologists in the eyes of other specialists, health care agencies, and the general public; carrying out high-impact research projects; basing professional practice on scientific evidence; and strengthening training in research. These are also some of the priority objectives of the AEDV.<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">1,2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The Research Unit of the Spanish Academy of Dermatology and Venereology Foundation (FAEDV) was created to meet these needs. The unit commenced operations in February 2012, following a public tender. At that time, the FAEDV already had several ongoing studies for which methodological support had been contracted from external companies. It was therefore considered necessary to create a stable professional structure, specialized in dermatology, which would be a more sustainable solution and would facilitate research within the AEDV.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">What are Research Unit's Goals?</span><p id="par0015" class="elsevierStylePara elsevierViewall">The primary objective of the Research Unit is to encourage the participation of AEDV members in methodologically sound multicenter studies, including systematic reviews and clinical practice guidelines. The unit should increase independent scientific output and the national and international profile of AEDV members and working groups, as well as the reputation of the academy itself, while at the same time improving the care of patients with skin diseases. Yet another objective is to increase research collaboration between different centers and to increase the representativeness and quality of the studies undertaken.</p><p id="par0020" class="elsevierStylePara elsevierViewall">In practice, our job is to facilitate the task of setting up and carrying out studies. Our ideal is that, for an individual researcher or an AEDV working group, the simplest way to set up a good research project with the best chance of success should be through the research unit. In this task we have the great advantage that AEDV membership represents over 95% of the dermatologists working in Spain and that the unit is more familiar with the research setting and the dermatological issues than any outside company.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Who Are the People in the Research Unit?</span><p id="par0025" class="elsevierStylePara elsevierViewall">The people currently carrying out the work of the research unit include the administrative and management staff of the AEDV (who play an essential role in the financial, legal and administrative management of projects), 2 staff members who provide methodological and statistical support, and the external support of project monitors and experts in electronic data collection. The services of documentalists, statisticians, and medical writers are contracted for specific jobs. A key component of the research unit is the group of over 150 academy members throughout Spain who are currently participating or have taken part in studies or courses organized by the unit, and who constitute the basis of its activity.</p><p id="par0030" class="elsevierStylePara elsevierViewall">The unit has a secure online data collection system that complies with all the legal requirements. It also makes use of AEDV's Juan de Azua virtual classroom to train project participants.</p><p id="par0035" class="elsevierStylePara elsevierViewall">The FAEDV's scientific committee supervises the activity of the unit and is responsible for making decisions on its scientific activity in order to ensure that this conforms to the mission and objectives established.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">What Does the Research Unit Do?</span><p id="par0040" class="elsevierStylePara elsevierViewall">To illustrate the activity of the research unit, we will describe the studies that it has been involved in since its creation in 2012.</p><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Spanish Registry of Systemic Therapy in Psoriasis (Biobadaderm)</span><p id="par0045" class="elsevierStylePara elsevierViewall">The Biobadaderm study predates the research unit and was one of the factors that influenced the unit's creation because it demonstrated the excellent results that could be obtained using the registry model. The Biobadaderm registry was launched in 2008 and today includes data from over 2000 patients, collected prospectively from 12 hospitals. The unit has been involved in the study since 2012. This project has been a good point of reference for the scientific activity of AEDV. The Spanish Agency for Medicines and Medical Devices (AEMPS) contributes funds to support Biobadaderm in Spain and is represented on the project's scientific committee. Since its creation, the Biobadaderm registry has formed part of the pharmacovigilance strategy of AEMPS. Biobadaderm has also contributed to the international recognition of AEDV's work. The registry is included in the European Network of Centres for Pharmacoepidemiology and Pharmacovigilance (ENCePP). Biobadaderm is also one of the most active members of the European Registry for Psoriasis (Psonet), which includes active European, Australian, and Israeli registries. It is represented on Psonet's scientific committee, leads 2 active projects, and has hosted 2 Psonet meetings. Moreover, articles based on Biobadaderm data, in which the research unit has collaborated since 2012, contribute to the dissemination of information about the AEDV's scientific activity.<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">3–6</span></a></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Spanish Registry of Mohs Surgery</span><p id="par0050" class="elsevierStylePara elsevierViewall">The Spanish Registry of Mohs Surgery was the unit's first large study and is a collaboration with the AEDV's Dermatologic Surgery, Cutaneous Oncology and Laser Therapy Group (GECIDOC). The objective is to collect information on Mohs surgery in Spain: its use, the results obtained, the resources used, and the factors influencing outcomes. The study began enrolling patients in June 2013, since when data has been collected from 800 patients treated in 15 hospitals. The first article reporting on this study will shortly be submitted for publication.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Clinical Trial of Photodynamic Therapy in Onychomycosis</span><p id="par0055" class="elsevierStylePara elsevierViewall">Initially, undertaking a clinical trial appeared to be an impossible task for a research unit of our size because of the complexity of the work and organization involved. However, in 2013, following several months of preparation, we started to enroll patients in this randomized clinical trial. In total, 60 patients were enrolled. The trial has been completed and the results will shortly be submitted for publication, This project has opened up the possibility of the FAEDV undertaking other studies, such as clinical trials of nondrug therapies and other independent clinical trials, as well as to the possibility of taking part in international studies, perhaps through the International Federation of Dermatology Clinical Trials Networks.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">7</span></a></p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Prioritization of Therapy Uncertainties in Dystrophic Epidermolysis Bullosa and Prioritization of Therapy Uncertainties in Ichthyosis</span><p id="par0060" class="elsevierStylePara elsevierViewall">The objective of these 2 studies was to produce lists of the priorities for clinical research identified by physicians, caregivers and patients in 2 serious and rare skin diseases: dystrophic epidermolysis bullosa and ichthyosis. In both studies, we have worked together with the Spanish national patient associations (DEBRA and ASIC) as well as, on the international level, the United Kingdom Database of Uncertainties about the Effects of Treatments (UK-DUETS).<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">8</span></a> Each of these studies involved the participation of over 100 people, including patients, caregivers, and expert clinicians (mostly members of the academy). The resulting article on epidermolysis bullosa has been published on the website of DEBRA International, and its recommendations have been taken into account by DEBRA and have led to changes in that organization's research strategy.<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">9,10</span></a> The report on the ichthyosis study has not yet been published. As a result of these studies, AEDV has become an affiliate of the James Lind Alliance.<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">11</span></a></p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Systematic Review of Phototherapy in Atopic Dermatitis</span><p id="par0065" class="elsevierStylePara elsevierViewall">A systematic review of phototherapy in atopic dermatitis was undertaken by the participants in one of the courses on the methodology of systematic reviews. The resulting review will be soon published in <span class="elsevierStyleItalic">Actas Dermo-Sifiliográficas</span>. Another objective of the research unit is to publish the results of its studies in <span class="elsevierStyleItalic">Actas</span> in order to contribute to the journal's development.</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Description of the Dermatologic Diseases Diagnosed in Ambulatory Care in Spain</span><p id="par0070" class="elsevierStylePara elsevierViewall">A study is currently being undertaken to collect data on the prevalence of different diseases in outpatient dermatology clinics in Spain and to test the feasibility of implementing a coding system. For the purposes of this study, we will solicit the participation of a representative group of academy members during the coming year. The results will be helpful in planning future studies and in improving the coding of dermatologic diseases in Spain. The study is being carried out in collaboration with the AEDV working group on Epidemiology and Promotion of Health in Dermatology. All of the scientific and legal preparations have already been completed and only the details of funding remain to be confirmed.</p><p id="par0075" class="elsevierStylePara elsevierViewall">The research unit has also collaborated or is beginning to collaborate with other studies, such as the Spanish Surveillance Network on Contact Allergies and the Spanish Lymphoma Registry.<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">12,13</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">In the area of education, we organize 2 accredited courses each year: an introduction to clinical research in the spring and a course on systematic reviews in the fall. The courses for the coming year (our fourth) are announced on the AEDV website. These courses serve as an introduction to participation in collaborative research and systematic review projects, and the participants gain an understanding of how such projects are undertaken in the research unit. More than 100 members have already attended courses, and it is our hope that this training program will also serve to publicize our scientific activity, as a greenhouse for ideas, and as a means of recruiting participants for new projects.</p><p id="par0085" class="elsevierStylePara elsevierViewall">The research unit can also act as an intermediary in the organization of international studies. In March 2013, for example, the AEDV hosted a meeting of the steering committee of European Dermatoepidemiology Network (EDEN). During the meeting, the members of the network (all leaders in clinical research in their own countries) were informed about the activities of the research unit and the AEDV's collaboration was offered for international studies. Our intention is to maintain this strategy of identifying possible international collaborations and publicizing our own activities.</p></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Is Maintaining the Research Unit a Feasible and Worthwhile Aim?</span><p id="par0090" class="elsevierStylePara elsevierViewall">We believe that the work carried out by the research unit over its two and a half years of operation dispels any doubt about the feasibility and worth of the unit. All of these projects have been useful for the academy and its members. During this period, the unit has been financially self-supporting and has generated sufficient revenues to cover its overhead. One essential aspect of its operation is to reconcile the need for research funding with the need to maintain the scientific rigor and independence that enhance the prestige of our society, always bearing in mind the ultimate goal of improving dermatologic care.</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">How Can You Participate?</span><p id="par0095" class="elsevierStylePara elsevierViewall">Studies organized by the research unit are open to all AEDV members who fulfill the conditions established by the specific protocol and those laid down by the scientific committee in charge of each project. If you are interested in participating in a study or collaborating in any other way, please contact us at <a href="mailto:investigacion@aedv.es">investigacion@aedv.es</a>.</p><p id="par0100" class="elsevierStylePara elsevierViewall">To propose a new study, please contact us. The required steps are described on the AEDV website in the section on research and projects under the title <span class="elsevierStyleItalic">Unidad de Investigación</span>. We welcome proposals for multicenter studies that are in line with the interests of the AEDV, and we can provide any help needed in filling out the simple form. Decisions on individual projects are made on the basis of a review of their feasibility and the priorities defined by the scientific committee.</p><p id="par0105" class="elsevierStylePara elsevierViewall">The annual courses on research and systematic review methodology are free, and scheduled dates are posted on the AEDV website calendar.</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">The Future of the Research Unit?</span><p id="par0110" class="elsevierStylePara elsevierViewall">The research unit is mandated to initiate new studies, including projects undertaken to improve our scientific activity and to enhance the care we provide our patients, including the definition of quality criteria and the evaluation of their use in dermatology practice. Another area of interest is the development of clinical practice guidelines. The future of the research unit will depend on the support of academy members and the participants in studies and courses, and on the work undertaken by the academy's internal bodies.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:7 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "What are Research Unit's Goals?" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Who Are the People in the Research Unit?" ] 2 => array:3 [ "identificador" => "sec0015" "titulo" => "What Does the Research Unit Do?" "secciones" => array:6 [ 0 => array:2 [ "identificador" => "sec0020" "titulo" => "Spanish Registry of Systemic Therapy in Psoriasis (Biobadaderm)" ] 1 => array:2 [ "identificador" => "sec0025" "titulo" => "Spanish Registry of Mohs Surgery" ] 2 => array:2 [ "identificador" => "sec0030" "titulo" => "Clinical Trial of Photodynamic Therapy in Onychomycosis" ] 3 => array:2 [ "identificador" => "sec0035" "titulo" => "Prioritization of Therapy Uncertainties in Dystrophic Epidermolysis Bullosa and Prioritization of Therapy Uncertainties in Ichthyosis" ] 4 => array:2 [ "identificador" => "sec0040" "titulo" => "Systematic Review of Phototherapy in Atopic Dermatitis" ] 5 => array:2 [ "identificador" => "sec0045" "titulo" => "Description of the Dermatologic Diseases Diagnosed in Ambulatory Care in Spain" ] ] ] 3 => array:2 [ "identificador" => "sec0050" "titulo" => "Is Maintaining the Research Unit a Feasible and Worthwhile Aim?" ] 4 => array:2 [ "identificador" => "sec0055" "titulo" => "How Can You Participate?" ] 5 => array:2 [ "identificador" => "sec0060" "titulo" => "The Future of the Research Unit?" ] 6 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: García-Doval I. La unidad de investigación de la Fundación Academia Española de Dermatología y Venereología. Actas Dermosifiliogr. 2015;106:346–349.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:13 [ 0 => array:3 [ "identificador" => "bib0070" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Plan estratégico de la Academia Española de Dermatología y Venereología (AEDV). FuturAEDV 2013-2017" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Ribera Pibernat" 1 => "J.C. Moreno Jiménez" 2 => "F. Valcuende Cavero" 3 => "J. Soto de Delas" 4 => "H. Vázquez Veiga" 5 => "P. Lázaro Ochaita" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ad.2014.02.008" "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2014" "volumen" => "105" "paginaInicial" => "639" "paginaFinal" => "654" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24725617" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0075" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "El plan estratégico de la Academia Española de Dermatología y Venereología" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.C. Moreno-Giménez" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ad.2014.04.001" "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2014" "volumen" => "105" "paginaInicial" => "633" "paginaFinal" => "634" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24813876" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0080" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Safety of classic and biologic systemic therapies for the treatment of psoriasis in elderly: An observational study from national BIOBADADERM registry" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Medina" 1 => "G. Carretero" 2 => "C. Ferrándiz" 3 => "E. Daudén" 4 => "F. Vanaclocha" 5 => "F.J. Gómez-García" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:2 [ "tituloSerie" => "J Eur Acad Dermatol Venereol" "fecha" => "2014 en prensa" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0085" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Risk of adverse events in psoriasis patients receiving classic systemic drugs and biologics in a 5-year observational study of clinical practice: 2008-2013 results of the Biobadaderm registry" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Carretero" 1 => "C. Ferrándiz" 2 => "E. Daudén" 3 => "F. Vanaclocha Sebastian" 4 => "F.J. Gómez-García" 5 => "E. Herrera-Ceballos" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:2 [ "tituloSerie" => "J Eur Acad Dermatol Venereol" "fecha" => "2014 en prensa" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0090" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Body mass index in patients with moderate-to-severe psoriasis in Spain and its impact as an independent risk factor for therapy withdrawal: Results of the Biobadaderm registry" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.M. Carrascosa" 1 => "M. Vilavella" 2 => "I. García-Doval" 3 => "G. Carretero" 4 => "F. Vanaclocha" 5 => "E. Daudén" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/jdv.12208" "Revista" => array:6 [ "tituloSerie" => "J Eur Acad Dermatol Venereol" "fecha" => "2014" "volumen" => "28" "paginaInicial" => "907" "paginaFinal" => "914" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23848131" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0095" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Latent tuberculosis infection and active tuberculosis in patients with psoriasis: A study on the incidence of tuberculosis and the prevalence of latent tuberculosis disease in patients with moderate-severe psoriasis in Spain BIOBADADERM registry" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A.I. Sánchez-Moya" 1 => "I. García-Doval" 2 => "G. Carretero" 3 => "J. Sanchez-Carazo" 4 => "C. Ferrándiz" 5 => "E. Herrera Ceballos" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/jdv.12011" "Revista" => array:7 [ "tituloSerie" => "J Eur Acad Dermatol Venereol" "fecha" => "2013" "volumen" => "27" "paginaInicial" => "1366" "paginaFinal" => "1374" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23134268" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0015028206031566" "estado" => "S300" "issn" => "00150282" ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0100" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "International Federation of Dermatology Clinical Trials Networks [cited 9 November 2014]. Available at: http://www.ifdctn.org/" ] ] ] 7 => array:3 [ "identificador" => "bib0105" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Database of Uncertainties about the Effects of Treatments (UK DUETs) [cited 9 November 2014]. Available at: http://www.nice.org.uk/about/what-we-do/evidence-services/database-of-uncertainties-about-the-effects-of-treatments-uk-duets" ] ] ] 8 => array:3 [ "identificador" => "bib0110" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Current dystrophic epidermolysis bullosa research does not match research needs perceived by patients and clinicians" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "P. Dávila-Seijo" 1 => "A. Hernández Martin" 2 => "E. Morcillo-Makow" 3 => "C. Rajan" 4 => "I. García Doval" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2014.05.038" "Revista" => array:7 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2014" "volumen" => "71" "paginaInicial" => "1008" "paginaFinal" => "1011" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25437964" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0015028208000368" "estado" => "S300" "issn" => "00150282" ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0115" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prioritization of therapy uncertainties in dystrophic epidermolysis bullosa: Where should research direct to? An example of priority setting partnership in very rare disorders" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P. Dávila-Seijo" 1 => "A. Hernández-Martin" 2 => "E. Morcillo-Makow" 3 => "R. de Lucas" 4 => "E. Dominguez" 5 => "N. Romero" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/1750-1172-8-61" "Revista" => array:6 [ "tituloSerie" => "Orphanet J Rare Dis" "fecha" => "2013" "volumen" => "8" "paginaInicial" => "61" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23607806" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0140673604174035" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0120" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "The James Lind Alliance [cited 9 November 2014]. Available at: http://www.lindalliance.org/" ] ] ] 11 => array:3 [ "identificador" => "bib0125" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Unidades de referencia para epidermólisis ampollosas e ictiosis: una necesidad urgente en España" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Hernández-Martin" 1 => "R. de Lucas" 2 => "A. Vicente" 3 => "E. Baselga" 4 => "E. Morcillo-Makow" 5 => "M.I. Arroyo Manzanal" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.adengl.2013.04.001" "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2013" "volumen" => "104" "paginaInicial" => "363" "paginaFinal" => "366" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23665435" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0130" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalencia de la epidermólisis ampollosa distrófica en España: estudio poblacional usando el método de captura-recaptura con 3 fuentes de datos. Evidencia de la necesidad de mejora en la atención sociosanitaria" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Hernández-Martin" 1 => "B. Aranegui" 2 => "M.J. Escamez" 3 => "R. de Lucas" 4 => "A. Vicente" 5 => "E. Rodriguez-Diaz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ad.2013.03.006" "Revista" => array:7 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2013" "volumen" => "104" "paginaInicial" => "890" "paginaFinal" => "896" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23809583" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0015028207012058" "estado" => "S300" "issn" => "00150282" ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010600000005/v1_201506041458/S1578219015000931/v1_201506041458/en/main.assets" "Apartado" => array:4 [ "identificador" => "6152" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Opinion Article" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010600000005/v1_201506041458/S1578219015000931/v1_201506041458/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015000931?idApp=UINPBA000044" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 7 | 8 | 15 |
| 2024 October | 66 | 56 | 122 |
| 2024 September | 98 | 29 | 127 |
| 2024 August | 108 | 77 | 185 |
| 2024 July | 85 | 44 | 129 |
| 2024 June | 108 | 33 | 141 |
| 2024 May | 75 | 45 | 120 |
| 2024 April | 73 | 41 | 114 |
| 2024 March | 93 | 28 | 121 |
| 2024 February | 87 | 30 | 117 |
| 2024 January | 77 | 25 | 102 |
| 2023 December | 70 | 20 | 90 |
| 2023 November | 71 | 35 | 106 |
| 2023 October | 60 | 26 | 86 |
| 2023 September | 81 | 44 | 125 |
| 2023 August | 59 | 21 | 80 |
| 2023 July | 62 | 36 | 98 |
| 2023 June | 64 | 25 | 89 |
| 2023 May | 60 | 25 | 85 |
| 2023 April | 43 | 18 | 61 |
| 2023 March | 37 | 23 | 60 |
| 2023 February | 46 | 19 | 65 |
| 2023 January | 45 | 16 | 61 |
| 2022 December | 56 | 30 | 86 |
| 2022 November | 25 | 15 | 40 |
| 2022 October | 35 | 27 | 62 |
| 2022 September | 37 | 66 | 103 |
| 2022 August | 29 | 38 | 67 |
| 2022 July | 29 | 44 | 73 |
| 2022 June | 16 | 21 | 37 |
| 2022 May | 32 | 24 | 56 |
| 2022 April | 69 | 43 | 112 |
| 2022 March | 83 | 47 | 130 |
| 2022 February | 33 | 35 | 68 |
| 2022 January | 35 | 25 | 60 |
| 2021 December | 34 | 35 | 69 |
| 2021 November | 27 | 41 | 68 |
| 2021 October | 35 | 48 | 83 |
| 2021 September | 26 | 37 | 63 |
| 2021 August | 28 | 26 | 54 |
| 2021 July | 29 | 30 | 59 |
| 2021 June | 33 | 33 | 66 |
| 2021 May | 36 | 24 | 60 |
| 2021 April | 91 | 60 | 151 |
| 2021 March | 66 | 14 | 80 |
| 2021 February | 76 | 28 | 104 |
| 2021 January | 48 | 21 | 69 |
| 2020 December | 43 | 17 | 60 |
| 2020 November | 38 | 17 | 55 |
| 2020 October | 27 | 8 | 35 |
| 2020 September | 31 | 13 | 44 |
| 2020 August | 23 | 17 | 40 |
| 2020 July | 36 | 20 | 56 |
| 2020 June | 40 | 28 | 68 |
| 2020 May | 35 | 28 | 63 |
| 2020 April | 35 | 23 | 58 |
| 2020 March | 32 | 17 | 49 |
| 2020 February | 5 | 0 | 5 |
| 2020 January | 0 | 2 | 2 |
| 2019 December | 5 | 5 | 10 |
| 2019 November | 0 | 7 | 7 |
| 2019 October | 1 | 2 | 3 |
| 2019 September | 5 | 1 | 6 |
| 2019 July | 0 | 3 | 3 |
| 2019 June | 2 | 1 | 3 |
| 2019 May | 0 | 12 | 12 |
| 2019 April | 1 | 0 | 1 |
| 2019 March | 2 | 8 | 10 |
| 2019 February | 2 | 0 | 2 |
| 2019 January | 1 | 0 | 1 |
| 2018 December | 2 | 0 | 2 |
| 2018 November | 1 | 0 | 1 |
| 2018 October | 3 | 0 | 3 |
| 2018 September | 5 | 0 | 5 |
| 2018 August | 0 | 6 | 6 |
| 2018 July | 0 | 2 | 2 |
| 2018 June | 0 | 2 | 2 |
| 2018 May | 0 | 14 | 14 |
| 2018 April | 0 | 2 | 2 |
| 2018 March | 1 | 3 | 4 |
| 2018 February | 19 | 5 | 24 |
| 2018 January | 27 | 8 | 35 |
| 2017 December | 32 | 8 | 40 |
| 2017 November | 32 | 12 | 44 |
| 2017 October | 26 | 3 | 29 |
| 2017 September | 15 | 15 | 30 |
| 2017 August | 26 | 10 | 36 |
| 2017 July | 24 | 19 | 43 |
| 2017 June | 29 | 18 | 47 |
| 2017 May | 25 | 12 | 37 |
| 2017 April | 23 | 11 | 34 |
| 2017 March | 16 | 33 | 49 |
| 2017 February | 20 | 10 | 30 |
| 2017 January | 15 | 11 | 26 |
| 2016 December | 25 | 18 | 43 |
| 2016 November | 22 | 17 | 39 |
| 2016 October | 25 | 22 | 47 |
| 2016 September | 0 | 10 | 10 |
| 2016 August | 0 | 5 | 5 |
| 2016 July | 6 | 2 | 8 |
| 2016 June | 14 | 4 | 18 |
| 2016 May | 7 | 4 | 11 |
| 2016 April | 7 | 2 | 9 |
| 2016 March | 10 | 1 | 11 |
| 2016 February | 9 | 5 | 14 |
| 2016 January | 7 | 2 | 9 |
| 2015 December | 10 | 0 | 10 |
| 2015 October | 0 | 4 | 4 |
| 2015 August | 0 | 4 | 4 |
| 2015 July | 2 | 3 | 5 |
| 2015 June | 8 | 5 | 13 |
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