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giving rise to the formation of keratin cysts&#46; There was also a small abscess with residues of fragmented collagen and the presence of macrophages and neutrophils &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; No fragmentation of elastic fibers was detected&#46; Special techniques did not reveal the presence of fungi or of mycobacteria&#46; A provisional diagnosis of phrynoderma was made based on these findings&#46; Blood tests confirmed the deficit of vitamin A &#40;0&#46;15<span class="elsevierStyleHsp" style=""></span>mg&#47;L &#91;normal range&#44; 0&#46;30-1<span class="elsevierStyleHsp" style=""></span>mg&#47;L&#93;&#41;&#44; as well as of vitamin E &#40;4&#46;9<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;mL &#91;normal range&#44; 5-20<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;mL&#93;&#41;&#44; Vitamin D<span class="elsevierStyleInf">3</span> &#40;14&#46;18<span class="elsevierStyleHsp" style=""></span>ng&#47;mL &#91;normal range&#44; 20-32<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#93;&#41;&#44; and zinc &#40;43<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;dL&#41;&#44; as well as a low hemoglobin level &#40;11&#46;4<span class="elsevierStyleHsp" style=""></span>g&#47;dL&#41; and low hematocrit 34&#37;&#46; Oral treatment was therefore prescribed as follows&#58; vitamin A &#40;1000<span class="elsevierStyleHsp" style=""></span>IU&#47;d&#41;&#59; vitamin E &#40;20<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#41;&#59; calcifediol &#40;1 ampoule of 3<span class="elsevierStyleHsp" style=""></span>mg&#47;1&#46;5<span class="elsevierStyleHsp" style=""></span>mL per week&#41;&#59; Hidroxil-B<span class="elsevierStyleInf">12</span>-B<span class="elsevierStyleInf">6</span>-B<span class="elsevierStyleInf">1</span>&#59; Dayamineral&#44; 1 tablet once a day&#59; ferrous iron &#40;80<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#41;&#59; and oil rich in medium-chain triglycerides&#46; After 7 months of treatment the skin lesions had not improved and the serum levels of vitamin A &#40;0&#46;11<span class="elsevierStyleHsp" style=""></span>mg&#47;L&#41; and vitamin E &#40;5&#46;1<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;mL&#41;&#44; Zn &#40;52<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;dL&#41;&#44; the hemoglobin level &#40;11&#46;0<span class="elsevierStyleHsp" style=""></span>g&#47;dL&#41;&#44; and the hematocrit 33&#37; were still low&#46; Intravenous iron &#40;500<span class="elsevierStyleHsp" style=""></span>mg of iron&#41;&#44; intramuscular vitamin A &#40;100&#160;000<span class="elsevierStyleHsp" style=""></span>IU&#47;mo&#41; and zinc sulfate &#40;22&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#41; were therefore added to the patient&#39;s treatment&#46; Three months later the vitamin levels were normal &#40;vitamin A&#44; 0&#46;38<span class="elsevierStyleHsp" style=""></span>mg&#47;L&#41;&#44; the anemia had resolved&#44; and only residual areas of hyperpigmentation were present on the skin &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Phrynoderma is the characteristic dermatosis associated with a deficiency of vitamin A&#44; a fat-soluble vitamin involved in numerous body functions&#46; Although this vitamin deficiency is common in Africa and southeast Asia&#44; phrynoderma is rare in Spain&#44; where it is associated with malabsorptive states&#44; such as pancreatic insufficiency&#44; colectomy&#44; and chronic giardiasis&#44; or arises as a complication of bariatric surgery&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Vitamin A deficiency is very common among patients who have undergone bariatric surgery and it has been associated with low prealbumin levels&#44; leading to a suggestion to use vitamin A levels as a marker of protein-energy malnutrition in these patients&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Phrynoderma is characterized by the presence of follicular hyperkeratosis&#44; mainly affecting the extensor surfaces of the limbs&#44; the abdomen&#44; and back&#46; It is often associated with xerosis and hyperpigmentation&#44; as well as extracutaneous manifestations such as night blindness&#46; The majority of reports of phrynoderma secondary to biliopancreatic bypass surgery describe atypical lesions that are larger and more inflammatory and tend to arise in atypical sites&#44; as occurred in our patient&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a> Deficits of many other essential oligoelements and vitamins observed in these patients may contribute to this atypical presentation&#44; particularly if we consider that phrynoderma does not appear to have a single etiology&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> For example&#44; furunculosis has been described in association with iron deficiency and has improved after restoring normal iron levels<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a>&#59; this diagnosis had to be considered in our patient as the first biopsies were compatible with this skin disorder&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">From a clinical point of view&#44; the differential diagnosis must include other skin conditions that have been described in association with bariatric surgery&#44; such as dermatosis-arthritis syndrome&#44; neutrophilic dermatosis attributed to the formation of circulating immune complexes produced in the blind loop of bowel&#44;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a> and acrodermatitis related to zinc deficiency&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> We also considered the perforating dermatoses&#44; although no association with bariatric surgery has been reported&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The increase in obesity in western society means that bariatric surgery will become more common&#46; The conclusion from the present case is that patients undergoing bariatric surgery must be followed up closely by a multidisciplinary team that is aware of the nutritional risks and complications&#44; as well as the appropriate therapeutic strategies that patients must follow for life&#46;</p></span>"
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Case and Research Letter
Phrynoderma After Biliopancreatic Diversion
Frinoderma asociado a derivación biliopancreática
L. Abada,
Corresponding author
laura.abad.polo@gmail.com

Corresponding author.
, T. Omisteb, J. Verac, Y. Gilaberted
a Medicina de Familia y Comunitaria, Hospital San Jorge, Huesca, Spain
b Servicio de Medicina Interna, Hospital San Jorge, Huesca, Spain
c Servicio de Anatomía Patológica, Hospital San Jorge, Huesca, Spain
d Servicio de Dermatología, Hospital San Jorge, Huesca, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Current surgical techniques for the treatment of morbid obesity can lead to major systemic complications&#46; Biliopancreatic bypass surgery is a mixed restrictive-malabsorptive type of bariatric surgery that combines partial gastrectomy with a gastroileal anastomosis&#44; causing the bile and pancreatic secretions to mix with the foods only in the final 50<span class="elsevierStyleHsp" style=""></span>cm of the small bowel&#46; In the long term&#44; this considerably reduces the absorption of vitamins&#44; oligoelements&#44; and essential fatty acids&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Our patient was a man of 46 years of age&#44; with a history of obesity&#44; hypertension&#44; tuberculous lymphadenitis in 2005&#44; a biliopancreatic bypass operation in 1999&#44; and operations for an anal fistula and to perform dermolipectomy in the hypogastrium and flanks&#46; He was on treatment with valsartan&#44; venotonic agents&#44; ferrous sulfate&#44; and Dayamineral &#40;a vitamin and mineral supplement&#41;&#46; He was seen in dermatology in 2012 for suppurating lesions on the lower limbs&#46; The lesions had appeared when he started to lose weight after the bariatric surgery and they had gradually spread to the trunk and upper limbs&#46; The diagnoses from 2 skin biopsies performed in 2003 were folliculitis and furuncle&#44; respectively&#46; Cultures for bacteria&#44; fungi&#44; and mycobacteria were repeatedly negative and various oral antibiotic treatments did not resolve the condition&#46; On physical examination there were violaceous papular and tuberose lesions&#44; some with scabs&#44; situated mainly on the thighs and on the medial aspect of the knees&#44; but with isolated lesions on the abdomen and on the proximal areas of the upper limbs &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41;&#46; Histopathology revealed the presence of intense hyperkeratosis in the pilosebaceous follicles&#44; giving rise to the formation of keratin cysts&#46; There was also a small abscess with residues of fragmented collagen and the presence of macrophages and neutrophils &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; No fragmentation of elastic fibers was detected&#46; Special techniques did not reveal the presence of fungi or of mycobacteria&#46; A provisional diagnosis of phrynoderma was made based on these findings&#46; Blood tests confirmed the deficit of vitamin A &#40;0&#46;15<span class="elsevierStyleHsp" style=""></span>mg&#47;L &#91;normal range&#44; 0&#46;30-1<span class="elsevierStyleHsp" style=""></span>mg&#47;L&#93;&#41;&#44; as well as of vitamin E &#40;4&#46;9<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;mL &#91;normal range&#44; 5-20<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;mL&#93;&#41;&#44; Vitamin D<span class="elsevierStyleInf">3</span> &#40;14&#46;18<span class="elsevierStyleHsp" style=""></span>ng&#47;mL &#91;normal range&#44; 20-32<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#93;&#41;&#44; and zinc &#40;43<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;dL&#41;&#44; as well as a low hemoglobin level &#40;11&#46;4<span class="elsevierStyleHsp" style=""></span>g&#47;dL&#41; and low hematocrit 34&#37;&#46; Oral treatment was therefore prescribed as follows&#58; vitamin A &#40;1000<span class="elsevierStyleHsp" style=""></span>IU&#47;d&#41;&#59; vitamin E &#40;20<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#41;&#59; calcifediol &#40;1 ampoule of 3<span class="elsevierStyleHsp" style=""></span>mg&#47;1&#46;5<span class="elsevierStyleHsp" style=""></span>mL per week&#41;&#59; Hidroxil-B<span class="elsevierStyleInf">12</span>-B<span class="elsevierStyleInf">6</span>-B<span class="elsevierStyleInf">1</span>&#59; Dayamineral&#44; 1 tablet once a day&#59; ferrous iron &#40;80<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#41;&#59; and oil rich in medium-chain triglycerides&#46; After 7 months of treatment the skin lesions had not improved and the serum levels of vitamin A &#40;0&#46;11<span class="elsevierStyleHsp" style=""></span>mg&#47;L&#41; and vitamin E &#40;5&#46;1<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;mL&#41;&#44; Zn &#40;52<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;dL&#41;&#44; the hemoglobin level &#40;11&#46;0<span class="elsevierStyleHsp" style=""></span>g&#47;dL&#41;&#44; and the hematocrit 33&#37; were still low&#46; Intravenous iron &#40;500<span class="elsevierStyleHsp" style=""></span>mg of iron&#41;&#44; intramuscular vitamin A &#40;100&#160;000<span class="elsevierStyleHsp" style=""></span>IU&#47;mo&#41; and zinc sulfate &#40;22&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#41; were therefore added to the patient&#39;s treatment&#46; Three months later the vitamin levels were normal &#40;vitamin A&#44; 0&#46;38<span class="elsevierStyleHsp" style=""></span>mg&#47;L&#41;&#44; the anemia had resolved&#44; and only residual areas of hyperpigmentation were present on the skin &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Phrynoderma is the characteristic dermatosis associated with a deficiency of vitamin A&#44; a fat-soluble vitamin involved in numerous body functions&#46; Although this vitamin deficiency is common in Africa and southeast Asia&#44; phrynoderma is rare in Spain&#44; where it is associated with malabsorptive states&#44; such as pancreatic insufficiency&#44; colectomy&#44; and chronic giardiasis&#44; or arises as a complication of bariatric surgery&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Vitamin A deficiency is very common among patients who have undergone bariatric surgery and it has been associated with low prealbumin levels&#44; leading to a suggestion to use vitamin A levels as a marker of protein-energy malnutrition in these patients&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Phrynoderma is characterized by the presence of follicular hyperkeratosis&#44; mainly affecting the extensor surfaces of the limbs&#44; the abdomen&#44; and back&#46; It is often associated with xerosis and hyperpigmentation&#44; as well as extracutaneous manifestations such as night blindness&#46; The majority of reports of phrynoderma secondary to biliopancreatic bypass surgery describe atypical lesions that are larger and more inflammatory and tend to arise in atypical sites&#44; as occurred in our patient&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a> Deficits of many other essential oligoelements and vitamins observed in these patients may contribute to this atypical presentation&#44; particularly if we consider that phrynoderma does not appear to have a single etiology&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> For example&#44; furunculosis has been described in association with iron deficiency and has improved after restoring normal iron levels<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a>&#59; this diagnosis had to be considered in our patient as the first biopsies were compatible with this skin disorder&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">From a clinical point of view&#44; the differential diagnosis must include other skin conditions that have been described in association with bariatric surgery&#44; such as dermatosis-arthritis syndrome&#44; neutrophilic dermatosis attributed to the formation of circulating immune complexes produced in the blind loop of bowel&#44;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a> and acrodermatitis related to zinc deficiency&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> We also considered the perforating dermatoses&#44; although no association with bariatric surgery has been reported&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The increase in obesity in western society means that bariatric surgery will become more common&#46; The conclusion from the present case is that patients undergoing bariatric surgery must be followed up closely by a multidisciplinary team that is aware of the nutritional risks and complications&#44; as well as the appropriate therapeutic strategies that patients must follow for life&#46;</p></span>"
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Article information
ISSN: 15782190
Original language: English
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Idiomas
Actas Dermo-Sifiliográficas
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