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zygomatic&#44; temporal&#44; and supraciliary regions&#46; No signs of inflammation or superficial flaking were observed &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41; and no similar lesions were detected at other sites&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Histopathology</span><p id="par0015" class="elsevierStylePara elsevierViewall">Histology of one of the lesions showed an intact epidermis and the deposition of a dark-yellow material between the collagen fibers in the superficial dermis&#59; the accumulations of this material showed a variable morphology&#46; The adnexa were not affected and there was no inflammatory infiltrate&#46; No signs of melanocyte proliferation or increased melanic pigment in the basement membrane were observed and no melanophages were present in the superficial dermis &#40;<a class="elsevierStyleCrossRefs" href="#fig0010">Figs&#46; 2 and 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">No other additional tests were requested&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">What Is Your Diagnosis&#63;</span></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Diagnosis</span><p id="par0030" class="elsevierStylePara elsevierViewall">Hydroquinone-induced exogenous ochronosis&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Clinical course</span><p id="par0035" class="elsevierStylePara elsevierViewall">During the diagnostic workup&#44; the patient revealed that for more than 20 years she had been applying a hydroquinone-containing product topically to the facial area to reduce her pigmentation&#46; She was instructed to discontinue using the product and treatment was started with topical retinoids&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Comment</span><p id="par0040" class="elsevierStylePara elsevierViewall">The term &#8220;cutaneous ochronosis&#8221; was first used by Virchow in 1866 to describe the accumulation of homogentisic acid in the papillary dermis&#46; However&#44; the term was being used in reference to ochronosis secondary to an endogenous pathogenic mechanism in a hereditary disease known as alcaptonuria&#44; in which there is an alteration of the enzyme homogentisate 1&#44;2-dioxygenase&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> It was not until 1975 that Findlay described a form of ochronosis caused by the prolonged use of skin-bleaching creams containing hydroquinone&#59; by the 1980s&#44; this had become the main worldwide cause of exogenous ochronosis&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Hydroquinone-induced exogenous ochronosis develops due to the prolonged topical application of hydroquinone&#59; 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in which the hyperpigmentation is typically widespread and affects the sclera and mucosas&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">The definitive diagnosis is made on histology&#44; confirming the presence of ochre-colored bodies in the superficial dermis&#44; between the collagen bundles&#59; the epidermis and adnexa are not affected&#46; These ochre-colored bodies can adopt different shapes&#44; the most typical being banana-shaped&#44; as can be observed in Figure<span class="elsevierStyleHsp" style=""></span>3 in a biopsy from our patient&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a> It is important to remember that these bodies are not arranged around the excretory ducts of the eccrine glands&#44; a feature characteristic of other diseases that are associated with hyperpigmentation but that are not due to the accumulation of homogentisic acid&#44; such as silver accumulation&#44; known as argyria&#46; Pseudo-ochronosis is a more common condition&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Therapeutically&#44; 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Case for Diagnosis
Patchy Facial Hyperpigmentation
Hiperpigmentación facial parcheada
S. Kindem
Corresponding author
sabrinakindemgomez@gmail.com

Corresponding author.
, C. Serra-Guillén, C. Guillén
Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Medical History</span><p id="par0005" class="elsevierStylePara elsevierViewall">The patient was a 62-year-old Brazilian woman who had been resident in Spain for 3 years&#46; She consulted for pigmented facial spots that had developed progressively over the previous 2 years&#46; She had no past medical history of interest and stated she was not taking any medication&#46; The lesions were asymptomatic and did not give rise to pruritus or pain&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Physical Examination</span><p id="par0010" class="elsevierStylePara elsevierViewall">The patient&#39;s skin was phototype V of the Fitzpatrick classification&#46; Physical examination revealed poorly defined patches of hyperpigmentation formed of palpable minute grayish papules on a brownish base bilaterally in the malar&#44; zygomatic&#44; temporal&#44; and supraciliary regions&#46; No signs of inflammation or superficial flaking were observed &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41; and no similar lesions were detected at other sites&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Histopathology</span><p id="par0015" class="elsevierStylePara elsevierViewall">Histology of one of the lesions showed an intact epidermis and the deposition of a dark-yellow material between the collagen fibers in the superficial dermis&#59; the accumulations of this material showed a variable morphology&#46; The adnexa were not affected and there was no inflammatory infiltrate&#46; No signs of melanocyte proliferation or increased melanic pigment in the basement membrane were observed and no melanophages were present in the superficial dermis &#40;<a class="elsevierStyleCrossRefs" href="#fig0010">Figs&#46; 2 and 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">No other additional tests were requested&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">What Is Your Diagnosis&#63;</span></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Diagnosis</span><p id="par0030" class="elsevierStylePara elsevierViewall">Hydroquinone-induced exogenous ochronosis&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Clinical course</span><p id="par0035" class="elsevierStylePara elsevierViewall">During the diagnostic workup&#44; the patient revealed that for more than 20 years she had been applying a hydroquinone-containing product topically to the facial area to reduce her pigmentation&#46; She was instructed to discontinue using the product and treatment was started with topical retinoids&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Comment</span><p id="par0040" class="elsevierStylePara elsevierViewall">The term &#8220;cutaneous ochronosis&#8221; was first used by Virchow in 1866 to describe the accumulation of homogentisic acid in the papillary dermis&#46; However&#44; the term was being used in reference to ochronosis secondary to an endogenous pathogenic mechanism in a hereditary disease known as alcaptonuria&#44; in which there is an alteration of the enzyme homogentisate 1&#44;2-dioxygenase&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> It was not until 1975 that Findlay described a form of ochronosis caused by the prolonged use of skin-bleaching creams containing hydroquinone&#59; by the 1980s&#44; this had become the main worldwide cause of exogenous ochronosis&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Hydroquinone-induced exogenous ochronosis develops due to the prolonged topical application of hydroquinone&#59; onset of the condition is more closely related to the duration of administration than to the concentration of the agent&#46; It most commonly affects phototypes IV and V&#44; which are those in which skin-bleaching treatments are typically used&#46; This prolonged use produces an inhibition of the enzyme homogentisate 1&#44;2-dioxygenase&#44; leading to an accumulation of homogentisic acid in the dermis&#46; Clinically&#44; patients present patches of hyperpigmented papules that resemble caviar eggs&#59; these papules block the follicular openings&#46; The changes are most evident in the area of the zygomatic arches and in the supraciliary region&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> Early stages may only present minimal erythema with mild inflammation&#46; The differential diagnosis should include melasma&#44; which is much more common but does not have papular lesions or follicular plugs&#44; and hyperpigmentation secondary to metal accumulation &#40;pseudo-ochronosis&#41;&#44; in which the hyperpigmentation is typically widespread and affects the sclera and mucosas&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">The definitive diagnosis is made on histology&#44; confirming the presence of ochre-colored bodies in the superficial dermis&#44; between the collagen bundles&#59; the epidermis and adnexa are not affected&#46; These ochre-colored bodies can adopt different shapes&#44; the most typical being banana-shaped&#44; as can be observed in Figure<span class="elsevierStyleHsp" style=""></span>3 in a biopsy from our patient&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a> It is important to remember that these bodies are not arranged around the excretory ducts of the eccrine glands&#44; a feature characteristic of other diseases that are associated with hyperpigmentation but that are not due to the accumulation of homogentisic acid&#44; such as silver accumulation&#44; known as argyria&#46; Pseudo-ochronosis is a more common condition&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Therapeutically&#44; the first measure is to discontinue the use of hydroquinone&#46; Numerous treatments have been described&#44; including topical retinoids&#44; chemical peeling with glycolic acid&#44; and carbon dioxide laser&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a> Currently&#44; the best results are achieved by treatment with the neodymium-doped yttrium aluminium garnet &#40;Nd&#58;YAG&#41; laser&#44; which fragments the ochre bodies and facilitates their phagocytosis&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a></p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Conflicts of Interest</span><p id="par0060" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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Article information
ISSN: 15782190
Original language: English
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Idiomas
Actas Dermo-Sifiliográficas
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