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array:23 [ "pii" => "S1578219015000529" "issn" => "15782190" "doi" => "10.1016/j.adengl.2015.03.002" "estado" => "S300" "fechaPublicacion" => "2015-05-01" "aid" => "1054" "copyright" => "Elsevier España, S.L.U. and AEDV" "copyrightAnyo" => "2014" "documento" => "article" "subdocumento" => "ssu" "cita" => "Actas Dermosifiliogr. 2015;106:260-70" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2315 "formatos" => array:3 [ "EPUB" => 52 "HTML" => 1360 "PDF" => 903 ] ] "Traduccion" => array:1 [ "es" => array:18 [ "pii" => "S000173101400413X" "issn" => "00017310" "doi" => "10.1016/j.ad.2014.06.016" "estado" => "S300" "fechaPublicacion" => "2015-05-01" "aid" => "1054" "copyright" => "Elsevier España, S.L.U. and AEDV" "documento" => "article" "subdocumento" => "ssu" "cita" => "Actas Dermosifiliogr. 2015;106:260-70" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2400 "formatos" => array:3 [ "EPUB" => 3 "HTML" => 953 "PDF" => 1444 ] ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Revisión</span>" "titulo" => "Histopatología de las alopecias. Parte II: alopecias cicatriciales" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "260" "paginaFinal" => "270" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Histologic Features of Alopecias: Part <span class="elsevierStyleSmallCaps">II</span>: Scarring Alopecias" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figura 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1059 "Ancho" => 1400 "Tamanyo" => 475941 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Pseudopelada de Brocq de larga evolución. A. Visión panorámica donde se observan columnas de fibrosis reemplazando a los folículos (HE x10). B. Detalle de la anterior mostrando fibrosis vertical entremezclada con elastosis actínica (HE x200). C. Corte transversal del mismo caso en el que se observan varias unidades foliculares (HE x20). D. A mayor aumento se aprecia fibroplasia concéntrica alrededor de restos foliculares (HE x200).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "C. Bernárdez, A.M. Molina-Ruiz, L. Requena" "autores" => array:3 [ 0 => array:2 [ "nombre" => "C." "apellidos" => "Bernárdez" ] 1 => array:2 [ "nombre" => "A.M." "apellidos" => "Molina-Ruiz" ] 2 => array:2 [ "nombre" => "L." "apellidos" => "Requena" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S1578219015000529" "doi" => "10.1016/j.adengl.2015.03.002" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015000529?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S000173101400413X?idApp=UINPBA000044" "url" => "/00017310/0000010600000004/v2_201505051016/S000173101400413X/v2_201505051016/es/main.assets" ] ] "itemSiguiente" => array:18 [ "pii" => "S1578219015000530" "issn" => "15782190" "doi" => "10.1016/j.adengl.2015.03.003" "estado" => "S300" "fechaPublicacion" => "2015-05-01" "aid" => "1102" "copyright" => "Elsevier España, S.L.U. and AEDV" "documento" => "article" "subdocumento" => "ssu" "cita" => "Actas Dermosifiliogr. 2015;106:271-7" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2582 "formatos" => array:3 [ "EPUB" => 46 "HTML" => 925 "PDF" => 1611 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Novelties in Dermatology</span>" "titulo" => "Systemic Treatment of Hyperhidrosis" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "271" "paginaFinal" => "277" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Tratamiento sistémico de la hiperhidrosis" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 84 "Ancho" => 150 "Tamanyo" => 22963 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Recommended therapeutic algoritm for the main forms of hyperhidrosis.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. del Boz" "autores" => array:1 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "del Boz" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731014005134" "doi" => "10.1016/j.ad.2014.11.012" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731014005134?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015000530?idApp=UINPBA000044" "url" => "/15782190/0000010600000004/v2_201505051007/S1578219015000530/v2_201505051007/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1578219015000372" "issn" => "15782190" "doi" => "10.1016/j.adengl.2014.09.019" "estado" => "S300" "fechaPublicacion" => "2015-05-01" "aid" => "1061" "copyright" => "Elsevier España, S.L.U. and AEDV" "documento" => "article" "subdocumento" => "ssu" "cita" => "Actas Dermosifiliogr. 2015;106:252-9" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1151 "formatos" => array:3 [ "EPUB" => 48 "HTML" => 624 "PDF" => 479 ] ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Review</span>" "titulo" => "Etanercept in the Treatment of Psoriatic Arthritis" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "252" "paginaFinal" => "259" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Etanercept en el tratamiento de la artritis psoriásica" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "L. Puig, A. López-Ferrer, A. Laiz" "autores" => array:3 [ 0 => array:2 [ "nombre" => "L." "apellidos" => "Puig" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "López-Ferrer" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Laiz" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731014004207" "doi" => "10.1016/j.ad.2014.09.004" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731014004207?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015000372?idApp=UINPBA000044" "url" => "/15782190/0000010600000004/v2_201505051007/S1578219015000372/v2_201505051007/en/main.assets" ] "en" => array:20 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Review</span>" "titulo" => "Histologic Features of Alopecias: Part <span class="elsevierStyleSmallCaps">II</span>: Scarring Alopecias" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "260" "paginaFinal" => "270" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "C. Bernárdez, A.M. Molina-Ruiz, L. Requena" "autores" => array:3 [ 0 => array:2 [ "nombre" => "C." "apellidos" => "Bernárdez" ] 1 => array:2 [ "nombre" => "A.M." "apellidos" => "Molina-Ruiz" ] 2 => array:4 [ "nombre" => "L." "apellidos" => "Requena" "email" => array:1 [ 0 => "lrequena@fjd.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Dermatología, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Histopatología de las alopecias. Parte II: alopecias cicatriciales" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1067 "Ancho" => 1401 "Tamanyo" => 534642 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Cicatricial alopecia in a plaque of chronic cutaneous lupus erythematosus. A, Few follicular units are observed in longitudinal sections (hematoxylin and eosin [HE] x10). B, Fibrosis around follicular remnants (HE x200). C, Same case with transversal sections (HE x20) D, Concentric fibrosis around follicular remnants (HE x200).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">In our daily clinical practice, dermatologists often encounter patients consulting for alopecia. In many cases, correct diagnosis of these conditions can be made from the presentation and course of hair loss. However, sometimes, a biopsy is necessary to enable a definitive diagnosis to be established. This article reviews in detail the main forms of cicatricial alopecias from a histopathological standpoint.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Cicatricial Alopecias</span><p id="par0010" class="elsevierStylePara elsevierViewall">Cicatricial alopecias are a group of conditions in which the hair follicles are replaced by vertical fibrotic tracts or hyalinized collagen, giving rise to permanent hair loss. This process manifests clinically as the loss of follicular ostia and cutaneous atrophy. There are many causes of secondary cicatricial alopecia, such as infiltrative processes (cutaneous metastasis, sarcoidosis), trauma (burns, radiation), and infections. However, the term cicatricial alopecia is used mainly to refer to primary cicatricial alopecias (PCAs), a group of diseases in which the hair follicle is the main target of the inflammatory process while the interfollicular dermis is spared.<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">1</span></a> Classification of cicatricial alopecias is confusing and controversial given that the etiology, in many cases, is unknown and the clinico-pathological characteristics overlap, vary over time, and depend on racial and genetic factors. In this article, we will analyze the classification established in 2001 by the North American Hair Research Society (NAHRS), which classifies PCAs according to the composition of the inflammatory infiltrate into lymphocytic, neutrophilic, and mixed types (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>).<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">2</span></a></p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">PCAs have an initial active phase, with more or less specific clinical characteristics. Scarred areas progressively start to appear, usually in the central area of the lesions. In advanced phases of the disease, differential diagnosis using clinical manifestations is therefore much more difficult if not impossible at times. Biopsy samples will be useful for establishing or confirming the diagnosis. For the sample to be representative, it should be taken from areas in which follicular ostia can still be observed. It is particularly useful to take a biopsy from the periphery of the lesions, areas of positive hair pull test, and areas of visible clinical activity. In addition, the diagnostic yield can be improved by taking the biopsy parallel to the follicle in order not to section it. If a single biopsy is taken, it is best to request transversal sectioning to enable multiple follicles to be observed at different levels.<a class="elsevierStyleCrossRefs" href="#bib0315"><span class="elsevierStyleSup">3,4</span></a> However, such an approach does not allow observation of the epidermis, dermis, and pilosebaceous units as a whole, something which can be of great use in this type of alopecia.<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">3</span></a> Therefore, faced with the suspicion of cicatricial alopecia, the best approach is to take 2 samples, one for transverse sectioning and the other for vertical sectioning. Moreover, staining for elastic fibers and direct immunofluorescence (DIF) can also be useful in the histopathological study of scarring alopecias. The key histopathological findings of use in the diagnosis of cicatricial alopecia are summarized in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>.</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Primary Lymphocytic Cicatricial Alopecias</span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Chronic Cutaneous/Discoid Lupus Erythematosus</span><p id="par0020" class="elsevierStylePara elsevierViewall">Patients with a variant of lupus erythematosus may present involvement of the scalp. Those with chronic cutaneous lupus erythematosus (CCLE), especially those with chronic discoid lupus erythematosus are, however, the only ones who progress to a cicatricial alopecia. In agreement with Sperling,<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">5</span></a> we prefer the term CCLE to discoid lupus erythematosus and this will be the term that we use in our descriptions. Patients with systemic lupus erythematosus can present with CCLE lesions, although most patients with CCLE do not have systemic disease. Among the patients with cutaneous involvement only, approximately 50% will have scalp involvement and very few will develop systemic disease. Clinically, these patients present erythematous and desquamative plaques of alopecia on the scalp, with epidermal atrophy. Dilated follicular infundibula are present with horny plugs. These plaques show a centrifugal growth, and several plaques can coalesce to form areas of cicatricial alopecia with irregular borders. The presence of a central hypopigmented area with peripheral hyperpigmentation is characteristic of advanced CCLE lesions in patients with medium-high phototype.</p><p id="par0025" class="elsevierStylePara elsevierViewall">On histopathology, active CCLE lesions on the scalp show a vacuolar-type interface dermatitis and a folliculocentric inflammatory lymphocytic infiltrate. This dermatitis tends to involve the interfollicular epidermis, although this structure may sometimes be spared, thereby complicating the diagnosis.<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">4</span></a> A common finding in CCLE, although also observed in lichen planopilaris (LPP), is the presence of colloid bodies, hyaline bodies, or Civatte bodies, as well as the presence of dyskeratosis in the follicular epithelium and the epidermis. It is common to observe dilated infundibula with laminar keratin present inside. Such a finding is common in PCAs in general, and clinically, this is manifest as the presence of horny plugs under physical examination. The folliculotropic inflammatory infiltrate is characteristically distributed around the infundibulum and the isthmus,<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">6</span></a> although it can also involve the entire follicle. This inflammatory infiltrate, which is predominantly lymphocytic although it often includes plasma cells, also has a superficial and deep perivascular pattern with a striking perieccrine distribution.<a class="elsevierStyleCrossRefs" href="#bib0320"><span class="elsevierStyleSup">4,6–9</span></a> Moreover, atrophy and destruction of the sebaceous glands are often observed from early stages.<a class="elsevierStyleCrossRefs" href="#bib0335"><span class="elsevierStyleSup">7,9</span></a> In the late stages, CCLE lesions show striking lamellar fibrosis, surrounding the upper follicle, although these lesions can also be panfollicular, and as the condition progresses, the follicle may be completely destroyed (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). As in other PCAs, foreign-body granulomas can be observed around free hair shafts lacking epithelial lining in the dermis.<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">7</span></a> In addition, interstitial mucin is often observed in the reticular dermis, and on occasions, the formation of germinal center lymphoid follicles is noted in the hypodermis.<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">10</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">Staining for elastic fibers can help in the differential diagnosis of CCLE with other PCAs. Advanced CCLE lesions show destruction of perifollicular elastic fibers,<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">11</span></a> whereas in the late LPP lesions, there is a cradle cap scar in the superficial dermis, with destruction of elastic fibers only in this area.<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">11</span></a> In the pseudopelade of Brocq (PB), elastic fibers are not only destroyed but also appear notably thickened.<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">11</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">DIF is also useful in the differential diagnosis of CCLE with other PCAs. A biopsy sample should ideally be taken from a lesion with onset at least 2 to 3 months earlier that has not been treated for at least 3 weeks.<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">12</span></a> On performing DIF in lesions with CCLE, IgG and C3 or IgM deposits are observed in a granular pattern or in a homogeneous band at the dermal-epidermal junction and the interface between the dermis and follicular the epithelium.<a class="elsevierStyleCrossRefs" href="#bib0325"><span class="elsevierStyleSup">5,8,13</span></a> IgA is present less frequently.<a class="elsevierStyleCrossRefs" href="#bib0325"><span class="elsevierStyleSup">5,13</span></a> In one study, a higher percentage of CCLE lesions in the scalp were positive in DIF when compared with biopsies taken from other anatomical regions.<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">12</span></a> Therefore, it is recommended to take a fresh biopsy for DIF whenever it is suspected that CCLE is among the conditions to be considered in a differential diagnosis for PCA.</p><p id="par0040" class="elsevierStylePara elsevierViewall">Finally, differential diagnosis of LPP and CCLE can be a challenge in some cases, especially when CCLE does not affect the surrounding epidermis. In these cases, the presence of inflammatory infiltrate with plasma cells and deep and perieccrine perivascular involvement, as well as the presence of dermal mucin and colloid bodies at the dermal-epidermal junction provide further support for diagnosis of CCLE.<a class="elsevierStyleCrossRef" href="#bib0370"><span class="elsevierStyleSup">14</span></a> Moreover, the presence of a periodic acid schiff-positive thickened basement membrane is a classic finding and often seen in chronic CCLE lesions,<a class="elsevierStyleCrossRefs" href="#bib0330"><span class="elsevierStyleSup">6,13</span></a> and may even be present in very advanced lesions.<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">6</span></a> Such observations can be of great help in the differential diagnosis of these 2 processes.<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">3</span></a></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Lichen Planopilaris</span><p id="par0045" class="elsevierStylePara elsevierViewall">LPP is the name used to define lichen planus when there is involvement of the hair follicles. It is divided into 3 types according to the clinical presentation: classic LPP, frontal fibrosing alopecia (FFA), and Graham Little syndrome. From the histopathological point of view, these 3 processes are almost indistinguishable, even in their active phases, and so they are described together. The clinical presentation of classic LPP on the scalp is very similar to that of CCLE. Large plaques with keratotic follicular papules and spiny follicular hyperkeratosis are present, in contrast to CCLE, in which the greatest activity is observed in the peripheral area,<a class="elsevierStyleCrossRefs" href="#bib0340"><span class="elsevierStyleSup">8,15</span></a> characteristically sparing follicles within the plaque of alopecia. The classic polygonal lesions in lichen planus are not observed in the scalp but they may be present in other body areas, and in that case, they may be of assistance in the diagnosis. Likewise, the typical mucosal or nail lesions in lichen planus may also support the diagnosis. The coexistence of LPP and vulvar lichen planus has been reported, for example.<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">16</span></a> FFA is considered a variant of LPP with a specific pattern, which gives rise to regression of the frontotemporal hairline and loss of eyebrows as the clinical manifestation.<a class="elsevierStyleCrossRefs" href="#bib0385"><span class="elsevierStyleSup">17–21</span></a> Finally, Graham Little syndrome is the term used for the triad of cicatricial alopecia of the scalp, keratotic follicular papules on the trunk and limbs, and reversible loss of pubic and/or axillary hair.</p><p id="par0050" class="elsevierStylePara elsevierViewall">Histopathologically, a lymphocytic interface dermatitis, usually of the lichenoid type, is observed in active lesions of LPP. This lesion spares the epidermis and interfollicular dermis and usually has perifollicular involvement (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). As in the clinical manifestations, not all hair follicles are found to be affected in the biopsy.<a class="elsevierStyleCrossRefs" href="#bib0330"><span class="elsevierStyleSup">6,7,21</span></a> The lichenoid infiltrate predominantly affects the permanent part of the follicle (infundibulum and isthmus), and may obscure the interface between the adventitial dermis and follicular epithelium,<a class="elsevierStyleCrossRefs" href="#bib0330"><span class="elsevierStyleSup">6,7,13,22–24</span></a> giving rise to an image in which the infiltrate and periinfundibular fibroplasia are strangling the infundibulum.<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">8</span></a> Above the infiltrate, the infundibulum appears dilated, and takes on a funnel-like appearace,<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">8</span></a> with hypergranulosis and layers of keratin, basophils, and orthokeratosis inside.<a class="elsevierStyleCrossRefs" href="#bib0410"><span class="elsevierStyleSup">22,33</span></a> These correlate with the clinical findings of spiny hyperkeratosis. The presence of several colloid bodies, made up of dyskeratotic keratinocytes, which are positive for cytokeratin stains, is noteworthy along the entire dermo-epidermal junction.<a class="elsevierStyleCrossRefs" href="#bib0410"><span class="elsevierStyleSup">22–24</span></a> As is the case with CCLE, sebaceous glands are atrophic or completely destroyed from the initial phases of the process.<a class="elsevierStyleCrossRefs" href="#bib0335"><span class="elsevierStyleSup">7,8,23</span></a> The deep vascular plexus, as well as other adnexal structures are not affected, and mucin deposits in the dermis are not a typical finding in LPP. At times, typical findings of lichen planus are observed in the biopsy,<a class="elsevierStyleCrossRefs" href="#bib0410"><span class="elsevierStyleSup">22,23</span></a> and these can be of great help in assisting the histopathologic diagnosis.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">As the condition progresses, concentric lamellar fibrosis is observed,<a class="elsevierStyleCrossRef" href="#bib0415"><span class="elsevierStyleSup">23</span></a> along with destruction of the hair follicles to be replaced by thick longitudinal fibrous tracts and the appearance of foreign-body granulomas.<a class="elsevierStyleCrossRef" href="#bib0420"><span class="elsevierStyleSup">24</span></a> Fibrosis has a limited presence in the adjacent tissue, but is more prominent in the papillary dermis and associated with epidermal atrophy.<a class="elsevierStyleCrossRef" href="#bib0415"><span class="elsevierStyleSup">23</span></a> Staining for elastic fibers will show a cradle cap scar centered on the follicle. The histopathologic changes in FFA and Graham Little syndrome cannot be differentiated from classic LPP,<a class="elsevierStyleCrossRefs" href="#bib0385"><span class="elsevierStyleSup">17,18</span></a> although the follicular triad has been reported. This consists of simultaneous involvement of different types of follicles (terminal, intermediate, and vellus) at different stages of the follicular cycle (anagen, catagen, and telogen) as a key histopathologic finding in the diagnosis of the initial phases of FFA.<a class="elsevierStyleCrossRef" href="#bib0425"><span class="elsevierStyleSup">25</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">The most difficult histopathologic differential diagnosis of LPP is with CCLE. The clinical-pathological correlation is particularly important in this respect. In particularly difficult cases, DIF may be of some use. In LPP, the abundant Civatte bodies are positive for IgM and less frequently for IgA, IgG, and C3, and they predominate in the follicular epithelium of the infundibulum and the isthmus.<a class="elsevierStyleCrossRefs" href="#bib0410"><span class="elsevierStyleSup">22,26,27</span></a> This finding, although a characteristic highly suggestive of LPP, is not pathognomonic, as it can also be observed in CCLE.<a class="elsevierStyleCrossRef" href="#bib0435"><span class="elsevierStyleSup">27</span></a> However, it seems that the two processes can be differentiated according to the composition of these Civatte bodies, which are formed of necrotic keratinocytes (expressing cytokeratins) in LPP and by aggregates of the basement membrane (positive for collagen IV) in CCLE.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Pseudopelade of Brocq</span><p id="par0065" class="elsevierStylePara elsevierViewall">There is much debate as to whether PB is a nosological entity or just the noninflammatory end stage of other PCAs. The term has been widely used in the dermatology literature ever since the first description by Brocq in 1885.<a class="elsevierStyleCrossRef" href="#bib0440"><span class="elsevierStyleSup">28</span></a> Several studies have attempted to clarify whether PB is a separate entity or not. Some authors clinically diagnose this entity in all patients who do not meet the criteria for LPP or CCLE, and they report that between 33%<a class="elsevierStyleCrossRef" href="#bib0445"><span class="elsevierStyleSup">29</span></a> and 69% (this latter percentage for early and active lesions)<a class="elsevierStyleCrossRef" href="#bib0450"><span class="elsevierStyleSup">30</span></a> may be diagnosed histopathologically as CCLE or LPP. In the most recent classification of the NAHRS in 2001, PB was described as a specific entity.<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">2</span></a> Sellheyer and Bergfeld<a class="elsevierStyleCrossRef" href="#bib0455"><span class="elsevierStyleSup">31</span></a> also considered PB as a separate entity, pointing out that there is a clear clinical and histopathologic absence of keratin plugs, and that the lesion retains the dermal network of elastic fibers. None of these findings are observed in LPP or CCLE.</p><p id="par0070" class="elsevierStylePara elsevierViewall">Clinically, the condition presents as small flesh-colored patches of alopecia without hyperkeratosis or signs of inflammation.<a class="elsevierStyleCrossRef" href="#bib0445"><span class="elsevierStyleSup">29</span></a> The plaques show a certain degree of atrophy, giving rise to the classic description of footprints in the snow.<a class="elsevierStyleCrossRef" href="#bib0460"><span class="elsevierStyleSup">32</span></a> The vertex and parietal regions are more frequently affected.<a class="elsevierStyleCrossRef" href="#bib0445"><span class="elsevierStyleSup">29</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">From an histopathologic point of view, PB is characterized by the absence of interface dermatitis, unlike LPP or CCLE, but distinctive histopathologic features of PB have not been reported.<a class="elsevierStyleCrossRef" href="#bib0465"><span class="elsevierStyleSup">33</span></a> Early lesions present scant or moderate perifollicular lymphocytic infiltrate, which predominates in the periinfundibular region.<a class="elsevierStyleCrossRef" href="#bib0445"><span class="elsevierStyleSup">29</span></a> Sebaceous glands are destroyed early in the process.<a class="elsevierStyleCrossRef" href="#bib0470"><span class="elsevierStyleSup">34</span></a> As the condition progresses, lamellar fibroplasia appears around the follicular infundibula, leading to complete destruction of the pilosebaceous unit, with the appearance of fibrous tracts in its place (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). The arrector pili muscle remains intact and foreign body granulomas can be observed around the hair shafts.<a class="elsevierStyleCrossRef" href="#bib0445"><span class="elsevierStyleSup">29</span></a> In PB, staining for elastic fibers shows these structures to be notably thickened both in the adventitial and reticular dermis,<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">11</span></a> an observation that assists in the differential diagnosis with other PCAs in advanced phases.</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Central Centrifugal Cicatricial Alopecia</span><p id="par0080" class="elsevierStylePara elsevierViewall">Central centrifugal cicatricial alopecia (CCCA) is a term coined by the NAHRS consensus group. It is defined as hair loss starting at the vertex region, and extending in a centrifugal pattern.<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">2</span></a> It is a descriptive term that is used to group entities such as the follicular degeneration syndrome, pseudopelade in African-Americans, and central elliptical pseudopelade in Caucasians.<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">2</span></a> There is substantial overlap in histopathological terms with PB, but the clinical presentation is different so clinico-pathologic correlation is essential for diagnosis of the 2 entities.</p><p id="par0085" class="elsevierStylePara elsevierViewall">Its pathogenesis is unknown. Sperling et al<a class="elsevierStyleCrossRefs" href="#bib0475"><span class="elsevierStyleSup">35,36</span></a> postulated that the process is the result of early degeneration of the inner root sheath leading to damage to the outer root sheaf by the hair shaft, triggering a chain of histopathological events that culminate in the scarring process. These authors considered that the finding of this premature degeneration of the inner root sheath, in absence of signs of inflammation, was very suggestive of follicular degeneration syndrome.<a class="elsevierStyleCrossRef" href="#bib0480"><span class="elsevierStyleSup">36</span></a> However, Gibbons and Ackerman,<a class="elsevierStyleCrossRef" href="#bib0485"><span class="elsevierStyleSup">37</span></a> Headington,<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">7</span></a> and Sulllivan and Kossard<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">10</span></a> do not consider CCCA to be an independent nosological entity and suggest that the histopathological changes present are nonspecific and similar to other PCAs. In fact, Ackerman et al.<a class="elsevierStyleCrossRef" href="#bib0490"><span class="elsevierStyleSup">38</span></a> considered that CCCA is really the end stage of a traction alopecia.</p><p id="par0090" class="elsevierStylePara elsevierViewall">The histopathological characteristics of CCCA have not been extensively described in the literature.<a class="elsevierStyleCrossRefs" href="#bib0320"><span class="elsevierStyleSup">4,8,35</span></a> In general, the findings reported are similar to the those of PB. A perifollicular lymphocytic infiltrate is observed around the upper part of the follicle, and sometimes in the perivascular region. Some authors have reported an asymmetric narrowing of the follicular wall, which is best observed in transversal sections, and this significantly displaces the hair shaft to an excentric location.<a class="elsevierStyleCrossRef" href="#bib0495"><span class="elsevierStyleSup">39</span></a> As the lesions progress, lamellar fibroplasia is observed, as well as destruction of the pilosebaceous units, giving rise to the development of cicatricial tissue in place of preexisting follicles. Staining for elastic fibers shows a similar pattern to PB.<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">11</span></a></p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Alopecia Mucinosa</span><p id="par0095" class="elsevierStylePara elsevierViewall">Alopecia mucinosa is an inflammatory process of the pilosebaceous unit that can be related to both permanent and reversible alopecia. The name refers to the main histopathological finding, the presence of intrafollicular mucin. This finding is considered a nonspecific reactive histopathological pattern,<a class="elsevierStyleCrossRefs" href="#bib0500"><span class="elsevierStyleSup">40,41</span></a> and the denomination of follicular mucinosis appears to be appropriate.<a class="elsevierStyleCrossRefs" href="#bib0500"><span class="elsevierStyleSup">40–42</span></a> Traditionally, alopecia mucinosa is classified in 2 types, a primary idiopathic form and another secondary to lymphomas. Given the large degree of overlap between the 2 entities, and given that cases of primary alopecia mucinosa that progress to lymphoma have been reported,<a class="elsevierStyleCrossRefs" href="#bib0510"><span class="elsevierStyleSup">42–44</span></a> the distinction might be artificial. Indeed, primary and secondary alopecia mucinosa could represent different aspects of a single disease spectrum. Primary alopecia mucinosa would thus be considered as a premalignant condition,<a class="elsevierStyleCrossRef" href="#bib0525"><span class="elsevierStyleSup">45</span></a> or as an indolent form of mycosis fungoides (MF) with good prognosis.<a class="elsevierStyleCrossRef" href="#bib0530"><span class="elsevierStyleSup">46</span></a> Clinically, both forms are characterized by presenting as grouped follicular papules, erythematous patches, and/or fluctuating plaques that more often affect the head and neck, but trunk and limb involvement has also been reported.<a class="elsevierStyleCrossRef" href="#bib0530"><span class="elsevierStyleSup">46</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">From the histopathological point of view, the earliest abnormality observed is mucin deposition between keratinocytes of the outer root sheath (<a class="elsevierStyleCrossRef" href="#fig0020">Fig. 4</a>). Intense deposition may give rise to the formation of mucin lakes that affect the entire follicle as well as the sebaceous gland.<a class="elsevierStyleCrossRefs" href="#bib0340"><span class="elsevierStyleSup">8,46</span></a> A perifollicular and intrafollicular lymphocytic infiltrate is observed, with lymphocytes of both normal and atypical appearance. Lymphocyte exocytosis can be observed in the follicular epithelium in the primary form.<a class="elsevierStyleCrossRef" href="#bib0530"><span class="elsevierStyleSup">46</span></a> Involvement of the dermis is variable, with a lymphocytic infiltrate with a superficial and profound perivascular pattern, as well as a diffuse pattern.<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">8</span></a> As in the clinical presentation, there are no reliable and reproducible histopathological characteristics to differentiate between primary alopecia mucinosa and the secondary lymphoma-associated form. Moreover, cellular atypia and monoclonal rearrangement of T cell receptor genes can be found in both forms, and so such observations are not useful for differential diagnosis.<a class="elsevierStyleCrossRef" href="#bib0530"><span class="elsevierStyleSup">46</span></a> In late stages, destruction of the pilosebaceous unit occurs, and residual tracts of mucin persist cuffed by inflammatory cells.<a class="elsevierStyleCrossRef" href="#bib0535"><span class="elsevierStyleSup">47</span></a> Unlike most PCAs, concentric lamellar fibrosis is not observed in alopecia mucinosa.<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">8</span></a> Routinely, staining for mucin is required. However, when we observe prominent spongiosis in the follicular epithelium, it is important to carry out differential diagnosis with atopic dermatitis; thus, the use of stains may be useful.<a class="elsevierStyleCrossRef" href="#bib0455"><span class="elsevierStyleSup">31</span></a> Eosinophilic folliculitis can also present with follicular mucinosis, but other additional histopathological characteristics are present to aid in differential diagnosis.<a class="elsevierStyleCrossRef" href="#bib0455"><span class="elsevierStyleSup">31</span></a></p><elsevierMultimedia ident="fig0020"></elsevierMultimedia></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Keratosis Follicularis Spinulosa Decalvans</span><p id="par0105" class="elsevierStylePara elsevierViewall">Keratosis follicularis spinulosa decalvans (KFSD), also known as keratosis pilaris decalvans or ichthyosis follicularis, is one of 3 entities that are included under the term keratosis pilaris atrophicans.<a class="elsevierStyleCrossRefs" href="#bib0540"><span class="elsevierStyleSup">48,49</span></a> The other 2 entities predominantly affect the face; these are keratosis pilaris atrophicans faciei and atrophoderma vermiculata. KFSD is considered an inherited X-linked genodermatosis.<a class="elsevierStyleCrossRef" href="#bib0550"><span class="elsevierStyleSup">50</span></a></p><p id="par0110" class="elsevierStylePara elsevierViewall">Clinically, it presents with areas of alopecia that show hyperkeratotic follicular papules and pustules. Onset often occurs during adolescence,<a class="elsevierStyleCrossRefs" href="#bib0540"><span class="elsevierStyleSup">48,49</span></a> and involvement is predominantly of the scalp, although the eyebrows and eyelashes can also be affected. In the scalp, areas already affected by alopecia can have residual keratin plugs, surrounded by perifollicular erythema, as well as more striking punctate atrophy on the face.<a class="elsevierStyleCrossRef" href="#bib0545"><span class="elsevierStyleSup">49</span></a> Keratosis pilaris on the trunk and limbs, corneal dystrophy, and photophobia may also be associated with plaques of alopecia.</p><p id="par0115" class="elsevierStylePara elsevierViewall">KFSD is classified by the NAHRS as a lymphocytic alopecia. However, although this is true in advanced disease or end stages,<a class="elsevierStyleCrossRef" href="#bib0540"><span class="elsevierStyleSup">48</span></a> the initial lesions also show a neutrophilic infiltrate.<a class="elsevierStyleCrossRef" href="#bib0545"><span class="elsevierStyleSup">49</span></a> The initial defect seems to be abnormal keratinization that gives rise to hypergranulosis and compact hyperkeratosis in the upper part of the infundibulum,<a class="elsevierStyleCrossRef" href="#bib0545"><span class="elsevierStyleSup">49</span></a> which correlate clinically with follicular plugs. In the next phase of acute inflammation, spongiosis appears along with a neutrophilic infiltrate in the infundibulum and adjacent epidermis. The course includes the appearance of a lymphocytic infiltrate associated with perifollicular fibrosis, predominantly in the upper part of the follicle. In the end stages, fibrosis is observed with the presence of foreign-body granulomas surrounding the hair shafts, as well as destruction of the hair follicle.<a class="elsevierStyleCrossRef" href="#bib0455"><span class="elsevierStyleSup">31</span></a></p></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Primary Neutrophilic Cicatricial Alopecias</span><p id="par0120" class="elsevierStylePara elsevierViewall">The category of primary neutrophilic cicatricial alopecias covers folliculitis in which the initial neutrophilic infiltrate is of importance in pathogenesis. In these cases, bacterial superinfection of the follicle and the consequent neutrophilic inflammatory response will be the basis for the clinical and histopathological findings. With the subsequent progression of the condition and the appearance of fibrosis, the infiltrate becomes a mixed.</p><p id="par0125" class="elsevierStylePara elsevierViewall">In the past, substantial clinical differences have been reported among the processes included within this group of alopecias. However, the histopathological findings are very similar, thus questioning if these are really distinct processes or just different stage within the same spectrum of lesions. With this possibility in mind, we will now review each entity separately to maintain the traditional nomenclature.</p><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Folliculitis Decalvans</span><p id="par0130" class="elsevierStylePara elsevierViewall">Folliculitis decalvans (FD) is a chronic and progressive pathological process characterized by destructive suppurative folliculitis. Clinically, it presents as plaques of alopecia with follicular pustules at the margins, where the lesion is active.<a class="elsevierStyleCrossRefs" href="#bib0340"><span class="elsevierStyleSup">8,13,51</span></a> The plaques predominate in the scalp, but they can also appear in other regions of the body with terminal follicles. On resolution, they leave a central scar.</p><p id="par0135" class="elsevierStylePara elsevierViewall">Histopathologically, when a biopsy is taken from the active border, it is possible to observe an acneiform dilatation of the follicular infundibulum, associated with an intrafollicular and perifollicular neutrophilic inflamatory infiltrate.<a class="elsevierStyleCrossRefs" href="#bib0365"><span class="elsevierStyleSup">13,51</span></a> With progression, the infiltrate will affect the entire follicle and will be made up mainly of lymphocytes and histiocytes, with plasma cells and multinucleated giant cells present. In addition, perifollicular and interstitial fibrosis is observed, with dermal involvement that is not directly perifollicular. Sullivan and Kossard<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">10</span></a> consider that the presence of plasma cells may be a key for the diagnosis of FD in its advanced states (<a class="elsevierStyleCrossRef" href="#fig0025">Fig. 5</a>). The final stages are characterized by the presence of fibrous tracts that replace the hair follicles. In addition, foreign-body granulomas can be observed around the hair shafts in direct contact with the dermis.</p><elsevierMultimedia ident="fig0025"></elsevierMultimedia><p id="par0140" class="elsevierStylePara elsevierViewall">At times, special staining may be necessary to rule out a microbial etiology. The main histopathological differential diagnosis is with dissecting cellulitis/folliculitis, which presents with absence of fistulous tracts and the interstitial infiltrate is only observed in advanced states. To help differentiate FD from acne keloidalis, the presence of fibrosis with hypertrophic scarring is only observed in the latter entity.</p><p id="par0145" class="elsevierStylePara elsevierViewall">Tufted hair folliculitis (THF) is a suppurative folliculitis in which multiple hair shafts emerge from a single follicular infundibulum.<a class="elsevierStyleCrossRefs" href="#bib0555"><span class="elsevierStyleSup">51,52</span></a> Often, cultures are positive for <span class="elsevierStyleItalic">Staphylococcus aureus</span> and the condition can coexist with FD. Some authors think that FP is pathognomonic of FD,<a class="elsevierStyleCrossRef" href="#bib0555"><span class="elsevierStyleSup">51</span></a> although the general consensus is that this is a nonspecific form of cicatricial alopecia,<a class="elsevierStyleCrossRefs" href="#bib0560"><span class="elsevierStyleSup">52,53</span></a> as it can be found in many primary and secondary cicatricial diseases. Histopathologically, a dilated infundibulum is observed with several hair shafts inside that emerge at the surface through a common follicular ostium.</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Dissecting Cellulitis/Folliculitis</span><p id="par0150" class="elsevierStylePara elsevierViewall">DC, initially known as perifolliculitis capitis abscedens et suffodiens, is a suppurative folliculitis, and so cellulitis is not an appropriate terminology. It is an entity considered within the tetrad of follicular occlusion, along with acne conglobata, hidradenitis suppurativa, and pilonidal cysts. These entities are characterized by abnormal follicular keratinization that gives rise to obstruction of the hair follicle, with secondary bacterial infection and subsequent destruction of the hair follicle.<a class="elsevierStyleCrossRef" href="#bib0570"><span class="elsevierStyleSup">54</span></a> Clinically, DC presents as deep inflammatory nodules that from the outset can cause alopecia in the overlying scalp. As the disease progresses, fluctuant plaques appear connected to one another by fistulous tracts, which can express purulent exudate through several ostia at the same time. The deep involvement can cause a cerebriform appearance of the scalp.</p><p id="par0155" class="elsevierStylePara elsevierViewall">In the initial lesions, dilatation of the infundibula is observed, and these can appear obstructed by horny plugs. Numerous neutrophils are present within the infundibula, leading to perforation of the follicular epithelium, with the subsequent formation of dermal and subcutaneous abscesses, which appear connected to one another by fistulous tracts coated with stratified squamous epithelium. This epithelium is derived from the outer root sheath of the proliferating follicle, and constitutes the main histopathological finding in this entity.<a class="elsevierStyleCrossRefs" href="#bib0335"><span class="elsevierStyleSup">7,13,51</span></a> In the most advanced stages, the infiltrate is of a mixed type, with the presence of lymphocytes, plasma cells, and foreign-body type giant cells. In this stage, extensive fibrosis is also present, surrounding the abscesses and fistulous tracts, with destruction of the hair follicles and subsequent cicatricial alopecia.</p><p id="par0160" class="elsevierStylePara elsevierViewall">The presence of fistulous tracts enables differential diagnosis of this entity to be established with other types of suppurative folliculitis of the scalp. However, the differential diagnosis with hidradenitis suppurativa is not possible based on histopathological findings. The different sites of the lesions in both entities can help us to make a definitive diagnosis.</p></span></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Primary Mixed Cicatricial Alopecias</span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Acne Keloidalis Nuchae</span><p id="par0165" class="elsevierStylePara elsevierViewall">The term acne keloidalis nuchae (AKN) is a misnomer as it refers to an entity that is not related to acne vulgaris and is not characterized by keloid lesions but rather hypertrophic lesions.<a class="elsevierStyleCrossRef" href="#bib0575"><span class="elsevierStyleSup">55</span></a> Clinically, this condition is characterized by the presence of millimetric follicular papules, which are firm to touch, can be scabby, umbilicated, or pustular, with hair within them.<a class="elsevierStyleCrossRefs" href="#bib0555"><span class="elsevierStyleSup">51,56</span></a> The papules-pustules can give rise to plaques with a keloidal appearance and nodules that can present purulent secretion. This condition predominantly affects black individuals.</p><p id="par0170" class="elsevierStylePara elsevierViewall">From an histopathologic point of view, inflammatory folliculitis is observed in which the inflammatory infiltrate is situated in the lower part of the isthmus. This infiltrate is granulomatous and is associated with a neutrophilic and lymphocytic infiltrate, occasionally with plasma cells in the upper and mid part.<a class="elsevierStyleCrossRefs" href="#bib0580"><span class="elsevierStyleSup">56,57</span></a> Sebaceous glands are destroyed in the early stages of this process, with an abundant inflammatory infiltrate in the surrounding area when incipient lesions are biopsied.<a class="elsevierStyleCrossRefs" href="#bib0580"><span class="elsevierStyleSup">56,57</span></a> It has been postulated that inflammatory involvement of the infundibulum, which damages its epithelium, triggers an attempt to repair the damage in the form of lamellar fibroplasia. However, this process is not usually effective, and the damaged follicle finally releases its hair shaft to the surrounding dermis leading to an acute and chronic granulomatous reaction, responsible for the clinical manifestation of papules with a firm consistency. The damaged hair shafts cannot be eliminated because of the involvement of the upper part of the follicle, thereby increasing the inflammatory and granulomatous reaction, with a continuous reparative process triggering that finally leads to hypertrophic scarring.<a class="elsevierStyleCrossRefs" href="#bib0580"><span class="elsevierStyleSup">56,57</span></a> Keloid-type streamers of collagen may infrequently be observed.<a class="elsevierStyleCrossRefs" href="#bib0575"><span class="elsevierStyleSup">55–57</span></a></p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Acne Necrotica Varioliformis</span><p id="par0175" class="elsevierStylePara elsevierViewall">Acne necrotica varioliformis is a rare dermatosis that presents as a necrotizing disorder of the hair follicle and gives rise to the appearance of varioliform scars. Clinically, it is characterized by repeated outbreaks of follicular papules-pustules with central necrosis in adult patients. These lesions leave a depressed scar.<a class="elsevierStyleCrossRef" href="#bib0590"><span class="elsevierStyleSup">58</span></a> The lesions are observed mainly in the frontal hairline, but also in other seborrheic regions of the face.<a class="elsevierStyleCrossRefs" href="#bib0590"><span class="elsevierStyleSup">58,59</span></a></p><p id="par0180" class="elsevierStylePara elsevierViewall">Histologically, the initial lesions present spongiosis and lymphocytic exocytosis in the follicular epithelium associated with dyskeratosis, with an abundant perifollicular and perivascular lymphocytic infiltrate.<a class="elsevierStyleCrossRef" href="#bib0590"><span class="elsevierStyleSup">58</span></a> As the lesions progress, necrotic keratinocytes coalesce to produce overall necrosis of the adjacent follicular epithelium, epidermis, and adventitial dermis. Residual fragments of hair shafts are often seen in this area of necrosis.</p></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Erosive Pustular Dermatosis</span><p id="par0185" class="elsevierStylePara elsevierViewall">Erosive pustular dermatosis of the scalp is an idiopathic pustulosis without a microbial cause. It has a chronic course with multiple relapses and is characterized by the presence of pustular lesions on the scalp, along with erosions and scabs that progress to scarring alopecia.<a class="elsevierStyleCrossRef" href="#bib0600"><span class="elsevierStyleSup">60</span></a> The histopathological findings are nonspecific,<a class="elsevierStyleCrossRef" href="#bib0600"><span class="elsevierStyleSup">60</span></a> with epidermal abnormalities such as erosions, atrophy, acanthosis, parakeratosis, and subcorneal pustules. A nonfolliculocentric infiltrate is usually present in the dermis. This infiltrate is of mixed nature and is associated with foreign-body type giant cells. In longstanding lesions, the number of follicles is usually decreased.</p></span></span><span id="sec0085" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Conflicts of Interest</span><p id="par0190" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:11 [ 0 => array:3 [ "identificador" => "xres494737" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec515964" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres494738" "titulo" => "Resumen" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0010" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec515965" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Cicatricial Alopecias" ] 6 => array:3 [ "identificador" => "sec0015" "titulo" => "Primary Lymphocytic Cicatricial Alopecias" "secciones" => array:6 [ 0 => array:2 [ "identificador" => "sec0020" "titulo" => "Chronic Cutaneous/Discoid Lupus Erythematosus" ] 1 => array:2 [ "identificador" => "sec0025" "titulo" => "Lichen Planopilaris" ] 2 => array:2 [ "identificador" => "sec0030" "titulo" => "Pseudopelade of Brocq" ] 3 => array:2 [ "identificador" => "sec0035" "titulo" => "Central Centrifugal Cicatricial Alopecia" ] 4 => array:2 [ "identificador" => "sec0040" "titulo" => "Alopecia Mucinosa" ] 5 => array:2 [ "identificador" => "sec0045" "titulo" => "Keratosis Follicularis Spinulosa Decalvans" ] ] ] 7 => array:3 [ "identificador" => "sec0050" "titulo" => "Primary Neutrophilic Cicatricial Alopecias" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0055" "titulo" => "Folliculitis Decalvans" ] 1 => array:2 [ "identificador" => "sec0060" "titulo" => "Dissecting Cellulitis/Folliculitis" ] ] ] 8 => array:3 [ "identificador" => "sec0065" "titulo" => "Primary Mixed Cicatricial Alopecias" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0070" "titulo" => "Acne Keloidalis Nuchae" ] 1 => array:2 [ "identificador" => "sec0075" "titulo" => "Acne Necrotica Varioliformis" ] 2 => array:2 [ "identificador" => "sec0080" "titulo" => "Erosive Pustular Dermatosis" ] ] ] 9 => array:2 [ "identificador" => "sec0085" "titulo" => "Conflicts of Interest" ] 10 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2014-04-29" "fechaAceptado" => "2014-06-14" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec515964" "palabras" => array:14 [ 0 => "Dermatopathology" 1 => "Alopecia" 2 => "Review" 3 => "Scarring alopecia" 4 => "Chronic cutaneous lupus erythematosus" 5 => "Follicular lichen planus" 6 => "Brocq pseudopelade" 7 => "Central centrifugal cicatricial alopecia" 8 => "Alopecia mucinosa" 9 => "Keratosis follicularis spinulosa decalvans" 10 => "Folliculitis decalvans" 11 => "Dissecting cellulitis/folliculitis" 12 => "Acne keloidalis nuchae" 13 => "Necrotizing lymphocytic folliculitis" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec515965" "palabras" => array:14 [ 0 => "Dermatopatología" 1 => "Alopecia" 2 => "Revisión" 3 => "Alopecias cicatriciales" 4 => "Lupus eritematoso cutáneo crónico" 5 => "Liquen plano folicular" 6 => "Pseudopelada de Brocq" 7 => "Alopecia cicatricial centrífuga central" 8 => "Alopecia mucinosa" 9 => "Queratosis folicular espinulosa decalvante" 10 => "Foliculitis decalvante" 11 => "Celulitis/foliculitis disecante" 12 => "Acné queloideo de la nuca" 13 => "Acné necrótico varioliforme" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The diagnosis of disorders of the hair and scalp can generally be made on clinical grounds, but clinical signs are not always diagnostic and in some cases more invasive techniques, such as a biopsy, may be necessary. This 2-part article is a detailed review of the histologic features of the main types of alopecia based on the traditional classification of these disorders into 2 major groups: scarring and nonscarring alopecias. Scarring alopecias are disorders in which the hair follicle is replaced by fibrous scar tissue, a process that leads to permanent hair loss. In nonscarring alopecias, the follicles are preserved and hair growth can resume when the cause of the problem is eliminated. In the second part of this review, we describe the histologic features of the main forms of scarring alopecia. Since a close clinical-pathological correlation is essential for making a correct histopathologic diagnosis of alopecia, we also include a brief description of the clinical features of the principal forms of this disorder.</p></span>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El diagnóstico de las enfermedades del cabello y del cuero cabelludo se basa, en la mayoría de las ocasiones, en el reconocimiento de signos clínicos; sin embargo, dichos signos no siempre son característicos y, en ocasiones, tenemos que recurrir a técnicas más invasivas como la realización de una biopsia. En este artículo se revisan de forma detallada las principales formas de alopecia desde un punto de vista histopatológico, y para ello se utiliza la clasificación tradicional de las alopecias que las divide en 2 grandes grupos: las alopecias cicatriciales y las no cicatriciales. Las alopecias cicatriciales son aquellas en las cuales el folículo piloso es sustituido por tejido fibroso cicatricial, causando una pérdida permanente del cabello. En las alopecias no cicatriciales el folículo permanece intacto y puede retomar su actividad cuando cesa el estímulo desencadenante. La segunda parte de este artículo revisa las principales formas de alopecia cicatricial desde un punto de vista histopatológico. Dado que una buena correlación clinicopatológica es fundamental para realizar el correcto diagnóstico histopatológico de las alopecias, en este artículo se incluye también una breve descripción de las características clínicas de las principales formas de alopecia.</p></span>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Bernárdez C, Molina-Ruiz AM, Requena L. Histopatología de las alopecias. Parte II: alopecias cicatriciales. Actas Dermosifiliogr. 2015;106:260–270.</p>" ] ] "multimedia" => array:7 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1067 "Ancho" => 1401 "Tamanyo" => 534642 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Cicatricial alopecia in a plaque of chronic cutaneous lupus erythematosus. A, Few follicular units are observed in longitudinal sections (hematoxylin and eosin [HE] x10). B, Fibrosis around follicular remnants (HE x200). C, Same case with transversal sections (HE x20) D, Concentric fibrosis around follicular remnants (HE x200).</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1079 "Ancho" => 1392 "Tamanyo" => 539434 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Lichen planopilaris. A, Perifollicular infiltrate is observed in longitudinal sections (hematoxylin and eosin [HE] x10). B, At higher magnification, lymphocytes are observed scattered in the follicular epithelium (HE X200). C, Same case studied with transversal sections (HE x20). D, At higher magnification, perifollicular concentric fibrosis and peripheral lymphocytic infiltrate are observed (HE x200).</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1059 "Ancho" => 1400 "Tamanyo" => 489515 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Longstanding pseudopelade of Brocq. A, Low-magnification view showing columns of fibrosis replacing the follicles (hematoxylin and eosin [HE] x10). B, Detail of the previous image showing vertical fibrosis mixed with actinic elastosis (HE x200). C, Transversal section of the same case, showing several follicular units (HE, X20). D, At higher magnification, concentric fibrosis around follicular remnants can be observed (HE x200).</p>" ] ] 3 => array:7 [ "identificador" => "fig0020" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 1050 "Ancho" => 1400 "Tamanyo" => 516085 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Alopecia mucinosa. A, Low-magnification view (hematoxylin and eosin [HE] x10). B, At higher magnification, lakes of mucin can be observed within the hair follicles (HE x20). C, Still higher magnification view showing mucin among the keratinocytes of the follicular epithelium and a large lake of mucin (HE x200). D, Detail of the granular basophilic material within the follicular epithelium (HE x 400).</p>" ] ] 4 => array:7 [ "identificador" => "fig0025" "etiqueta" => "Figure 5" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr5.jpeg" "Alto" => 1132 "Ancho" => 1391 "Tamanyo" => 490965 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Folliculitis decalvans. A, Low magnification view showing several broken hair follicles with perifollicular fibrosis (hematoxylin and eosin [HE] x10). B, Detail of the previous image showing an infundibular cyst surrounded by inflammatory infiltrate and below a pigmented hair shaft surrounded by multinucleated giant cells (HE x 200). C, Transversal sections showing perifollicular fibrosis and cuffs of infiltrate around the hair follicles (HE x20). D, At higher magnification, the infiltrate can been seen to be made up of lymphocytes and plasma cells (HE x200).</p>" ] ] 5 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Main Composition of the Inflammatory Infiltrate \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Entities \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Lymphocytic \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Chronic cutaneous lupus erythematosus (CCLE) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Lichen planopilaris (LPP) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Pseudopelade of Brocq \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Central centrifugal cicatricial alopecia (CCCA) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Alopecia mucinosa \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Keratosis follicularis spinulosa decalvans (KFSD) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Neutrophilic \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Folliculitis decalvans (FD) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Dissecting cellulitis (DC) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Mixed \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Acne keloidalis nuchae (AKN) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Acne necrotica varioliformis \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Erosive pustular dermatosis \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Nonspecific \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab785814.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Classification of Primary Cicatricial Alopecias (PSA) According to the North American Hair Research Society (NAHRS).</p>" ] ] 6 => array:7 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Type of Alopecia \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Key Histopathological Features \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Chronic cutaneous lupus erythematosus (CCLE) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Vacuolar-type interface dermatitis \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Folliculocentric lymphocytic inflammatory infiltrate \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Dilated infundibula containing laminar keratin \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Destruction of perifollicular elastic fibers \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">IgG and C3 deposits at the interface between the dermis and the follicular epithelium \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Lichen planopilaris (LPP) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Lichenoid-type interface dermatitis \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Folliculocentric lymphocytic inflammatory infiltrate \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Concentric lamellar fibrosis \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Cradle cap scar with destruction of elastic fibers \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Pseudopelade of Brocq (PB) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Diagnosis by exclusion in absence of findings characteristic of other cicatricial alopecias \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Central centrifugal cicatricial alopecia (CCCA) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Lamellar fibroplasia around follicular infundibula \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Fibrous tracts replacing pilosebaceous unit \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Thickened elastic fibers in the dermis \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Alopecia mucinosa \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Mucin deposits in the outer root sheaf \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Lakes of intrafollicular mucin \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Keratosis follicularis spinulosa decalvans (KFSD) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Compact hyperkeratosis in the infundibulum \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Mixed neutrophilic/lymphocytic inflammatory infiltrate \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Primary Neutrophilic Cicatricial Alopecias \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Intrafollicular and perifollicular neutrophilic inflammatory infiltrate \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Perifollicular and interstitial fibrosis \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Several hair shafts emerging from a follicular infundibulum (tufted hair folliculitis) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Foreign-body type granulomatous reaction to broken hair shafts. \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab785813.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Key Histopathological Features of Primary Cicatricial Alopecias.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:60 [ 0 => array:3 [ "identificador" => "bib0305" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ 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Year/Month | Html | Total | |
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2024 November | 33 | 7 | 40 |
2024 October | 706 | 83 | 789 |
2024 September | 320 | 71 | 391 |
2024 August | 355 | 98 | 453 |
2024 July | 354 | 74 | 428 |
2024 June | 276 | 73 | 349 |
2024 May | 294 | 108 | 402 |
2024 April | 254 | 57 | 311 |
2024 March | 259 | 71 | 330 |
2024 February | 274 | 70 | 344 |
2024 January | 293 | 73 | 366 |
2023 December | 403 | 65 | 468 |
2023 November | 441 | 79 | 520 |
2023 October | 379 | 77 | 456 |
2023 September | 402 | 76 | 478 |
2023 August | 304 | 50 | 354 |
2023 July | 343 | 96 | 439 |
2023 June | 357 | 70 | 427 |
2023 May | 283 | 52 | 335 |
2023 April | 322 | 51 | 373 |
2023 March | 269 | 58 | 327 |
2023 February | 199 | 59 | 258 |
2023 January | 207 | 92 | 299 |
2022 December | 164 | 82 | 246 |
2022 November | 48 | 42 | 90 |
2022 October | 38 | 51 | 89 |
2022 September | 43 | 91 | 134 |
2022 August | 37 | 73 | 110 |
2022 July | 34 | 59 | 93 |
2022 June | 30 | 58 | 88 |
2022 May | 281 | 100 | 381 |
2022 April | 362 | 125 | 487 |
2022 March | 363 | 102 | 465 |
2022 February | 319 | 98 | 417 |
2022 January | 285 | 111 | 396 |
2021 December | 248 | 105 | 353 |
2021 November | 257 | 102 | 359 |
2021 October | 319 | 110 | 429 |
2021 September | 201 | 89 | 290 |
2021 August | 240 | 138 | 378 |
2021 July | 175 | 88 | 263 |
2021 June | 171 | 63 | 234 |
2021 May | 339 | 63 | 402 |
2021 April | 292 | 152 | 444 |
2021 March | 213 | 57 | 270 |
2021 February | 139 | 43 | 182 |
2021 January | 118 | 37 | 155 |
2020 December | 97 | 57 | 154 |
2020 November | 98 | 51 | 149 |
2020 October | 91 | 53 | 144 |
2020 September | 127 | 34 | 161 |
2020 August | 72 | 47 | 119 |
2020 July | 55 | 41 | 96 |
2020 June | 63 | 51 | 114 |
2020 May | 69 | 56 | 125 |
2020 April | 52 | 33 | 85 |
2020 March | 43 | 30 | 73 |
2020 February | 4 | 1 | 5 |
2020 January | 4 | 4 | 8 |
2019 December | 4 | 1 | 5 |
2019 November | 4 | 8 | 12 |
2019 October | 1 | 8 | 9 |
2019 September | 0 | 10 | 10 |
2019 August | 4 | 11 | 15 |
2019 July | 4 | 21 | 25 |
2019 June | 5 | 19 | 24 |
2019 May | 5 | 39 | 44 |
2019 April | 2 | 30 | 32 |
2019 March | 2 | 12 | 14 |
2019 February | 0 | 5 | 5 |
2019 January | 4 | 4 | 8 |
2018 December | 2 | 7 | 9 |
2018 October | 2 | 0 | 2 |
2018 September | 6 | 1 | 7 |
2018 July | 0 | 2 | 2 |
2018 June | 0 | 5 | 5 |
2018 May | 0 | 8 | 8 |
2018 April | 1 | 2 | 3 |
2018 March | 60 | 3 | 63 |
2018 February | 168 | 13 | 181 |
2018 January | 99 | 17 | 116 |
2017 December | 86 | 22 | 108 |
2017 November | 67 | 18 | 85 |
2017 October | 70 | 37 | 107 |
2017 September | 51 | 14 | 65 |
2017 August | 38 | 30 | 68 |
2017 July | 44 | 34 | 78 |
2017 June | 63 | 38 | 101 |
2017 May | 52 | 36 | 88 |
2017 April | 40 | 29 | 69 |
2017 March | 32 | 45 | 77 |
2017 February | 94 | 32 | 126 |
2017 January | 46 | 16 | 62 |
2016 December | 48 | 24 | 72 |
2016 November | 90 | 31 | 121 |
2016 October | 59 | 34 | 93 |
2016 September | 0 | 13 | 13 |
2016 August | 0 | 9 | 9 |
2016 July | 11 | 14 | 25 |
2016 June | 3 | 11 | 14 |
2016 May | 9 | 9 | 18 |
2016 April | 7 | 7 | 14 |
2016 March | 5 | 16 | 21 |
2016 February | 5 | 8 | 13 |
2016 January | 4 | 7 | 11 |
2015 December | 8 | 13 | 21 |
2015 November | 5 | 7 | 12 |
2015 October | 0 | 18 | 18 |
2015 September | 0 | 25 | 25 |
2015 August | 0 | 21 | 21 |
2015 July | 15 | 12 | 27 |
2015 June | 10 | 16 | 26 |
2015 May | 20 | 27 | 47 |