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          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Siliconomas with a snowstorm pattern&#46; Red arrow&#44; hyperechoic image corresponding to the filler material&#46; Green arrow&#44; posterior acoustic shadow&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The increase in the number of cosmetic procedures in recent years means that in our daily practice we are seeing ever more side effects of the different techniques&#46; One of these is the formation of granulomas secondary to dermal fillers&#59; the etiology of these lesions can be difficult to determine&#44; not only because patients neglect to inform us they have undergone cosmetic treatment or they are unaware of the type of material used&#44; but also because the clinical presentation can be similar to that of certain dermatologic diseases&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> When medicolegal issues arise&#44; the most useful additional test is biopsy&#44; as each material presents a specific histologic pattern&#44;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> but this is an invasive technique and patients may sometimes reject such tests&#46; Skin ultrasound is an alternative&#44; non-invasive test that&#44; through specific sonographic patterns&#44; can identify the type of material involved and its exact site&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">We present the case of a 52-year-old woman who came to outpatients for multiple asymptomatic lesions on the forehead&#46; The first lesions had appeared in the glabellar region 8 years earlier and had remained stable until the year prior to consultation when&#44; coinciding with the appearance of new lesions&#44; she developed recurrent episodes of inflammation that persisted for several days and resolved spontaneously&#46; Physical examination revealed yellowish-pink plaques of 1-2<span class="elsevierStyleHsp" style=""></span>cm diameter&#44; with well-defined borders&#44; a firm consistency&#44; and a peau d&#8217;orange appearance &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The only finding of interest in the patient&#39;s past history was the injection of a filler material 14 years earlier&#59; she was unable to specify what the material was&#46; On biopsy there were abundant foamy histiocytes suggestive of a histiocytic reaction to the filler material &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Due to the lack of specific findings&#44; we decided to perform skin ultrasound to identify the filler material employed&#46; The study revealed hyperechoic images that had no clearly visible border and that left an acoustic shadow&#59; the images were present in the skin and deeper tissues of the frontal and malar regions and of the chin&#46; The sonographic pattern corresponded to the so-called snowstorm sign &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#44; which is compatible with a diagnosis of siliconomas&#46; In this case&#44; skin ultrasound enabled us to define the type of material employed and its presence in other areas in addition to those in which the patient stated the injections had been performed&#46; This made it possible to plan management&#46; At the time of writing&#44; the patient had completed 3 months of treatment with isotretinoin&#44; 0&#46;4<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;d&#44; which has led to a partial improvement in the lesions&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">High-frequency ultrasound is a simple and rapid non-invasive technique with a good cost-efficacy relationship&#46; The technique enables us to identify the nature&#44; volume&#44; and site of the injected material&#46; The thickness of the soft tissues does not affect image quality&#44; and the material in question can be identified in 97&#46;5&#37; of cases&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Ultrasound can differentiate between reabsorbable and permanent filler materials&#44; though it cannot distinguish between different materials of the same class&#46; Absorbable materials are seen as anechoic or hypoechoic masses with the appearance of cysts whereas permanent materials produce a hyperechoic pattern&#59; semiabsorbable materials are seen as hypoechoic areas that contain foci of variable echogenicity&#46; Liquid silicone can produce a specific pattern known as a snowstorm pattern because of the presence of multiple hyperechoic collections with an acoustic shadow&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">We consider that skin ultrasound can be very useful when filler materials give rise to complications and it can provide a valid alternative for those patients who&#44; for whatever reason&#44; do not wish to undergo biopsy&#46; Ultrasound establishes the clinical diagnosis more accurately than other imaging studies&#8212;the presence of a permanent material&#44; such as calcium hydroxyapatite&#44; can give false positive results with magnetic resonance&#44; computed tomography&#44; and positron emission tomography&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> In addition&#44; ultrasound can aid decision-taking regarding subsequent treatment as&#44; for example&#44; the presence of a permanent filler material would contraindicate treatment with interferon&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a> Ultrasound can also help us to orient patients about the prognosis as&#44; in contrast to reabsorbable filler materials&#44; granulomatous reactions to permanent materials are unlikely to resolve in less than 6 months&#46; Furthermore&#44; knowledge of the site and nature of a filler material will make it possible to avoid future complications if further interventions are to be performed at the same site&#46; Finally&#44; some authors consider that ultrasound study improves the patient&#39;s awareness of the cosmetic results achieved and&#44; 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Case and Research Letter
The Utility of Skin Ultrasound for the Diagnosis of Complications of Tissue Filler Materials
Utilidad de la ecografía cutánea en el diagnóstico de las complicaciones por materiales de relleno
D. Menis
Corresponding author
diana.menis@hotmail.it

Corresponding author.
, M. Castellanos-González, R. Llamas-Martín, F. Vanaclocha Sebastián
Servicio de Dermatología, Hospital 12 de Octubre, Madrid, Spain
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    "titulo" => "The Utility of Skin Ultrasound for the Diagnosis of Complications of Tissue Filler Materials"
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          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Siliconomas with a snowstorm pattern&#46; Red arrow&#44; hyperechoic image corresponding to the filler material&#46; Green arrow&#44; posterior acoustic shadow&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The increase in the number of cosmetic procedures in recent years means that in our daily practice we are seeing ever more side effects of the different techniques&#46; One of these is the formation of granulomas secondary to dermal fillers&#59; the etiology of these lesions can be difficult to determine&#44; not only because patients neglect to inform us they have undergone cosmetic treatment or they are unaware of the type of material used&#44; but also because the clinical presentation can be similar to that of certain dermatologic diseases&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> When medicolegal issues arise&#44; the most useful additional test is biopsy&#44; as each material presents a specific histologic pattern&#44;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> but this is an invasive technique and patients may sometimes reject such tests&#46; Skin ultrasound is an alternative&#44; non-invasive test that&#44; through specific sonographic patterns&#44; can identify the type of material involved and its exact site&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">We present the case of a 52-year-old woman who came to outpatients for multiple asymptomatic lesions on the forehead&#46; The first lesions had appeared in the glabellar region 8 years earlier and had remained stable until the year prior to consultation when&#44; coinciding with the appearance of new lesions&#44; she developed recurrent episodes of inflammation that persisted for several days and resolved spontaneously&#46; Physical examination revealed yellowish-pink plaques of 1-2<span class="elsevierStyleHsp" style=""></span>cm diameter&#44; with well-defined borders&#44; a firm consistency&#44; and a peau d&#8217;orange appearance &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The only finding of interest in the patient&#39;s past history was the injection of a filler material 14 years earlier&#59; she was unable to specify what the material was&#46; On biopsy there were abundant foamy histiocytes suggestive of a histiocytic reaction to the filler material &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Due to the lack of specific findings&#44; we decided to perform skin ultrasound to identify the filler material employed&#46; The study revealed hyperechoic images that had no clearly visible border and that left an acoustic shadow&#59; the images were present in the skin and deeper tissues of the frontal and malar regions and of the chin&#46; The sonographic pattern corresponded to the so-called snowstorm sign &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#44; which is compatible with a diagnosis of siliconomas&#46; In this case&#44; skin ultrasound enabled us to define the type of material employed and its presence in other areas in addition to those in which the patient stated the injections had been performed&#46; This made it possible to plan management&#46; At the time of writing&#44; the patient had completed 3 months of treatment with isotretinoin&#44; 0&#46;4<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;d&#44; which has led to a partial improvement in the lesions&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">High-frequency ultrasound is a simple and rapid non-invasive technique with a good cost-efficacy relationship&#46; The technique enables us to identify the nature&#44; volume&#44; and site of the injected material&#46; The thickness of the soft tissues does not affect image quality&#44; and the material in question can be identified in 97&#46;5&#37; of cases&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Ultrasound can differentiate between reabsorbable and permanent filler materials&#44; though it cannot distinguish between different materials of the same class&#46; Absorbable materials are seen as anechoic or hypoechoic masses with the appearance of cysts whereas permanent materials produce a hyperechoic pattern&#59; semiabsorbable materials are seen as hypoechoic areas that contain foci of variable echogenicity&#46; Liquid silicone can produce a specific pattern known as a snowstorm pattern because of the presence of multiple hyperechoic collections with an acoustic shadow&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">We consider that skin ultrasound can be very useful when filler materials give rise to complications and it can provide a valid alternative for those patients who&#44; for whatever reason&#44; do not wish to undergo biopsy&#46; Ultrasound establishes the clinical diagnosis more accurately than other imaging studies&#8212;the presence of a permanent material&#44; such as calcium hydroxyapatite&#44; can give false positive results with magnetic resonance&#44; computed tomography&#44; and positron emission tomography&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> In addition&#44; ultrasound can aid decision-taking regarding subsequent treatment as&#44; for example&#44; the presence of a permanent filler material would contraindicate treatment with interferon&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a> Ultrasound can also help us to orient patients about the prognosis as&#44; in contrast to reabsorbable filler materials&#44; granulomatous reactions to permanent materials are unlikely to resolve in less than 6 months&#46; Furthermore&#44; knowledge of the site and nature of a filler material will make it possible to avoid future complications if further interventions are to be performed at the same site&#46; Finally&#44; some authors consider that ultrasound study improves the patient&#39;s awareness of the cosmetic results achieved and&#44; in those patients not convinced of the persistence of an injected material&#44; the ultrasound images can reinforce their perception of the definitive results&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">In our opinion&#44; although biopsy continues to be the gold standard for the definitive diagnosis of the side effects of an injected filler material&#44; skin ultrasound is a valid and useful alternative diagnostic method in patients who reject invasive diagnostic tests&#46;</p></span>"
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Article information
ISSN: 15782190
Original language: English
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2022 March 56 71 127
2022 February 50 22 72
2022 January 66 44 110
2021 December 44 42 86
2021 November 53 36 89
2021 October 47 59 106
2021 September 47 37 84
2021 August 39 32 71
2021 July 28 34 62
2021 June 36 18 54
2021 May 32 23 55
2021 April 51 64 115
2021 March 41 18 59
2021 February 61 32 93
2021 January 28 7 35
2020 December 40 11 51
2020 November 26 14 40
2020 October 30 13 43
2020 September 23 7 30
2020 August 16 21 37
2020 July 32 21 53
2020 June 28 20 48
2020 May 31 14 45
2020 April 36 13 49
2020 March 33 21 54
2020 February 6 1 7
2019 December 4 2 6
2019 November 0 2 2
2019 September 4 1 5
2019 July 0 2 2
2019 June 2 0 2
2019 May 1 12 13
2019 April 0 10 10
2019 March 2 7 9
2019 January 1 0 1
2018 December 2 0 2
2018 November 1 0 1
2018 October 5 0 5
2018 September 2 0 2
2018 August 0 17 17
2018 July 0 4 4
2018 June 0 5 5
2018 May 0 6 6
2018 April 0 5 5
2018 March 3 3 6
2018 February 21 2 23
2018 January 36 8 44
2017 December 34 7 41
2017 November 40 9 49
2017 October 29 5 34
2017 September 32 14 46
2017 August 49 10 59
2017 July 45 6 51
2017 June 45 8 53
2017 May 21 20 41
2017 April 19 7 26
2017 March 16 11 27
2017 February 14 7 21
2017 January 19 9 28
2016 December 36 8 44
2016 November 44 12 56
2016 October 38 11 49
2016 September 1 6 7
2016 August 0 2 2
2016 July 13 2 15
2016 June 14 0 14
2016 May 14 9 23
2016 April 11 0 11
2016 March 8 8 16
2016 February 12 1 13
2016 January 8 2 10
2015 December 12 3 15
2015 November 12 2 14
2015 October 5 12 17
2015 September 5 3 8
2015 August 13 1 14
2015 July 32 4 36
2015 June 30 3 33
2015 May 32 3 35
2015 April 7 2 9
2015 March 5 2 7
2015 February 8 4 12
2015 January 8 1 9
2014 December 4 3 7
2014 November 4 1 5
2014 October 10 1 11
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Idiomas
Actas Dermo-Sifiliográficas
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¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?