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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Congenital fascial dystrophy &#40;CFD&#41; or stiff skin syndrome is a rare skin disease that was described in 1971 by Esterly and McKusick&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The condition is characterized by noninflammatory fibrosis of the subcutaneous cellular tissue and of the muscle fascia&#44; leading to hardening of the skin and interference with movement of the underlying joints&#46; It can be hereditary and show a very variable degree of severity&#44; sometimes causing minimal symptoms&#44; as in the case we describe below&#44; in which the diagnosis was made in adulthood&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The patient was a 46-year-old man with no past medical history of interest&#46; He had been referred from another hospital with a clinical suspicion of morphea profunda that had not responded to treatment with oral corticosteroids&#46; The patient stated that since childhood he had had difficulty performing certain movements&#44; such as flexing the trunk&#44; and that it had been impossible to administer intramuscular injections into the right buttock&#46; He also said that his daughter had similar symptoms&#46; Examination revealed difficulty raising a skin fold in the lumbar and right gluteal regions &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figs&#46; 1 and 2</a>&#41;&#44; where the skin was hard to the touch&#44; and a limitation of movement of the right hip&#44; particularly flexion&#46; Investigations performed at the previous hospital included an autoimmunity study that was normal&#44; magnetic resonance imaging&#44; which excluded bone or muscle involvement&#44; and skin biopsy&#44; which was reported to be consistent with morphea profunda&#46; The biopsy was reviewed&#58; thickened collagen was observed in a horizontally oriented lattice pattern in the deepest layers of the dermis&#44; and there was no inflammatory infiltrate &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 3</a>&#41;&#46; We made a diagnosis of CFD based on the clinical and pathological findings&#44; and physiotherapy was recommended&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">CFD is a very rare disorder and descriptions are scarce in the literature&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> It affects men and women equally&#44; and a family history is found in 30&#37; of patients&#46; In the case described&#44; the targeted history enabled us to identify a daughter with similar symptoms&#44; though&#44; at the time of writing&#44; no additional tests had been performed to confirm the diagnosis&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The pathogenesis of this disease was unknown until recently&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> However&#44; Loeys et al&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> discovered that all affected individuals had a mutation in the <span class="elsevierStyleItalic">fibrillin-1</span> gene&#46; This protein&#44; which is also mutated in patients with Marfan syndrome&#44; is mainly involved in the formation of microfibrils &#40;formed of fibrillin polymers&#41;&#44; which&#44; together with elastin&#44; form the elastic fibers&#46; This mutation leads to a disorganized accumulation of microfibrils in the dermis&#59; this can be observed on confocal or electron microscopy&#46; These accumulations produce abnormal activation of another molecule&#44; transforming growth factor &#40;TGF-&#946;&#41;&#44; which has the ability to promote collagen deposition in the dermis&#46; The increased TGF-&#946; levels in patients with CFD leads to greater collagen deposition in the deeper regions of the dermis&#44; the subcutaneous cellular tissue&#44; and the muscle fascia&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Clinical manifestations are usually present at birth&#44; but they can also appear during the first 6 years of life&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Patients with CFD have clearly circumscribed areas of hardened skin with no visible changes to the skin surface&#59; these areas arise particularly around the pelvic or shoulder girdles and on the proximal areas of the thighs&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Less common findings include hypertrichosis&#44; hyperpigmentation in the affected areas&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> and the presence of subcutaneous nodules on the distal phalanges of the fingers&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">The main problem caused by this condition is limitation of joint movement&#46; In the majority of patients this limitation is mild and does not interfere excessively with daily life&#59; however&#44; changes can sometimes be very widespread and can even limit lung capacity&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> If the symptoms are mild&#44; the diagnosis may not be made until adult life&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Not only the clinical manifestations but also the microscopic findings are very important&#46; Microscopy reveals a proliferation of collagen tissue&#44; particularly in the muscle fascia and in the subcutaneous cellular tissue&#44; although there are reports of cases in which only the reticular dermis is affected&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> It is important to note that involvement of the muscle fascia is not a prerequisite for making the diagnosis&#46; The term <span class="elsevierStyleItalic">congenital fascial dystrophy</span> was proposed in the original description of the disorder because the fascia was found to be affected in all the patients with this diagnosis&#46; However&#44; not all cases diagnosed since that time have had fascial involvement&#46; The most characteristic microscopy finding suggestive of CFD is not so much the site of the excess collagen&#44; but its arrangement in a lattice-like array&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> Other typical features are the absence of an inflammatory infiltrate and the presence of mucin&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Finally&#44; to confirm the diagnosis it is important to exclude the presence of specific autoantibodies and of structural bone or muscle lesions&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">The main condition to be taken into account in the differential diagnosis is morphea profunda&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> In contrast to CFD&#44; morphea profunda usually has an asymmetric distribution&#44; it does not present at an early age&#44; visible skin changes are usually present&#44; and&#44; microscopically&#44; the collagen is compact&#46; In addition&#44; in the initial phases there is usually a lymphoplasmacytic inflammatory infiltrate&#46; In pansclerotic morphea of childhood&#44; although the sclerotic process is also deep&#44; as in CFD&#44; the presence of very evident skin changes&#44; including ulcers and pigment disorders&#44; makes differentiation easy&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">No effective treatment for CFD exists&#46; Numerous drugs&#44; including topical and oral corticosteroids&#44; methotrexate&#44; and psoralen&#8211;UV-A&#44; have been tried and the results have been very poor with all of them&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Only physiotherapy appears to be able to improve joint comfort and movement&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The interest in knowing CFD and being able to make a correct diagnosis derives mainly from the need to differentiate it from morphea profunda&#44; a condition with similar clinical and microscopic characteristics&#46; Only in this way is it possible to avoid the administration of potentially harmful drugs that&#44; in the case of CFD&#44; would be totally ineffective&#46;</p></span>"
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                            3 => "M&#46;L&#46; Williams"
                            4 => "M&#46;K&#46; Connolly"
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Case and Research Letter
Congenital Fascial Dystrophy or Stiff Skin Syndrome: A Case Report
Distrofia fascial congénita o síndrome de la piel rígida: presentación de un caso
A. Plana Pla
Corresponding author
adriplanapla@yahoo.es

Corresponding author.
, I. Bielsa Marsol, M. Fernández-Figueras, C. Ferrándiz Foraster
Departamento de Dermatología, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Congenital fascial dystrophy &#40;CFD&#41; or stiff skin syndrome is a rare skin disease that was described in 1971 by Esterly and McKusick&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The condition is characterized by noninflammatory fibrosis of the subcutaneous cellular tissue and of the muscle fascia&#44; leading to hardening of the skin and interference with movement of the underlying joints&#46; It can be hereditary and show a very variable degree of severity&#44; sometimes causing minimal symptoms&#44; as in the case we describe below&#44; in which the diagnosis was made in adulthood&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The patient was a 46-year-old man with no past medical history of interest&#46; He had been referred from another hospital with a clinical suspicion of morphea profunda that had not responded to treatment with oral corticosteroids&#46; The patient stated that since childhood he had had difficulty performing certain movements&#44; such as flexing the trunk&#44; and that it had been impossible to administer intramuscular injections into the right buttock&#46; He also said that his daughter had similar symptoms&#46; Examination revealed difficulty raising a skin fold in the lumbar and right gluteal regions &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figs&#46; 1 and 2</a>&#41;&#44; where the skin was hard to the touch&#44; and a limitation of movement of the right hip&#44; particularly flexion&#46; Investigations performed at the previous hospital included an autoimmunity study that was normal&#44; magnetic resonance imaging&#44; which excluded bone or muscle involvement&#44; and skin biopsy&#44; which was reported to be consistent with morphea profunda&#46; The biopsy was reviewed&#58; thickened collagen was observed in a horizontally oriented lattice pattern in the deepest layers of the dermis&#44; and there was no inflammatory infiltrate &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 3</a>&#41;&#46; We made a diagnosis of CFD based on the clinical and pathological findings&#44; and physiotherapy was recommended&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">CFD is a very rare disorder and descriptions are scarce in the literature&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> It affects men and women equally&#44; and a family history is found in 30&#37; of patients&#46; In the case described&#44; the targeted history enabled us to identify a daughter with similar symptoms&#44; though&#44; at the time of writing&#44; no additional tests had been performed to confirm the diagnosis&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The pathogenesis of this disease was unknown until recently&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> However&#44; Loeys et al&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> discovered that all affected individuals had a mutation in the <span class="elsevierStyleItalic">fibrillin-1</span> gene&#46; This protein&#44; which is also mutated in patients with Marfan syndrome&#44; is mainly involved in the formation of microfibrils &#40;formed of fibrillin polymers&#41;&#44; which&#44; together with elastin&#44; form the elastic fibers&#46; This mutation leads to a disorganized accumulation of microfibrils in the dermis&#59; this can be observed on confocal or electron microscopy&#46; These accumulations produce abnormal activation of another molecule&#44; transforming growth factor &#40;TGF-&#946;&#41;&#44; which has the ability to promote collagen deposition in the dermis&#46; The increased TGF-&#946; levels in patients with CFD leads to greater collagen deposition in the deeper regions of the dermis&#44; the subcutaneous cellular tissue&#44; and the muscle fascia&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Clinical manifestations are usually present at birth&#44; but they can also appear during the first 6 years of life&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Patients with CFD have clearly circumscribed areas of hardened skin with no visible changes to the skin surface&#59; these areas arise particularly around the pelvic or shoulder girdles and on the proximal areas of the thighs&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Less common findings include hypertrichosis&#44; hyperpigmentation in the affected areas&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> and the presence of subcutaneous nodules on the distal phalanges of the fingers&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">The main problem caused by this condition is limitation of joint movement&#46; In the majority of patients this limitation is mild and does not interfere excessively with daily life&#59; however&#44; changes can sometimes be very widespread and can even limit lung capacity&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> If the symptoms are mild&#44; the diagnosis may not be made until adult life&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Not only the clinical manifestations but also the microscopic findings are very important&#46; Microscopy reveals a proliferation of collagen tissue&#44; particularly in the muscle fascia and in the subcutaneous cellular tissue&#44; although there are reports of cases in which only the reticular dermis is affected&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> It is important to note that involvement of the muscle fascia is not a prerequisite for making the diagnosis&#46; The term <span class="elsevierStyleItalic">congenital fascial dystrophy</span> was proposed in the original description of the disorder because the fascia was found to be affected in all the patients with this diagnosis&#46; However&#44; not all cases diagnosed since that time have had fascial involvement&#46; The most characteristic microscopy finding suggestive of CFD is not so much the site of the excess collagen&#44; but its arrangement in a lattice-like array&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> Other typical features are the absence of an inflammatory infiltrate and the presence of mucin&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Finally&#44; to confirm the diagnosis it is important to exclude the presence of specific autoantibodies and of structural bone or muscle lesions&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">The main condition to be taken into account in the differential diagnosis is morphea profunda&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> In contrast to CFD&#44; morphea profunda usually has an asymmetric distribution&#44; it does not present at an early age&#44; visible skin changes are usually present&#44; and&#44; microscopically&#44; the collagen is compact&#46; In addition&#44; in the initial phases there is usually a lymphoplasmacytic inflammatory infiltrate&#46; In pansclerotic morphea of childhood&#44; although the sclerotic process is also deep&#44; as in CFD&#44; the presence of very evident skin changes&#44; including ulcers and pigment disorders&#44; makes differentiation easy&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">No effective treatment for CFD exists&#46; Numerous drugs&#44; including topical and oral corticosteroids&#44; methotrexate&#44; and psoralen&#8211;UV-A&#44; have been tried and the results have been very poor with all of them&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Only physiotherapy appears to be able to improve joint comfort and movement&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The interest in knowing CFD and being able to make a correct diagnosis derives mainly from the need to differentiate it from morphea profunda&#44; a condition with similar clinical and microscopic characteristics&#46; Only in this way is it possible to avoid the administration of potentially harmful drugs that&#44; in the case of CFD&#44; would be totally ineffective&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Plana Pla A&#44; Bielsa Marsol I&#44; Fern&#225;ndez-Figueras M&#44; Ferr&#225;ndiz Foraster C&#46; Distrofia fascial cong&#233;nita o s&#237;ndrome de la piel r&#237;gida&#58; presentaci&#243;n de un caso&#46; Actas Dermosifiliogr&#46; 2014&#59;105&#58;805&#8211;807&#46;</p>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">1&#44; The skin of the lumbar region showed no visible changes&#44; but it was difficult to pinch it into a fold&#46; 2&#44; The skin of the buttock was similar to that of the lumbar region&#59; it felt hard to the touch but there were no changes visible on the surface&#46;</p>"
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