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The epidermis and the upper dermis are essentially unremarkable. Inflammatory cells are limited to the stroma surrounding the eccrine sweat glands (hematoxylin–eosin, original magnification 40×).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. Bassas-Vila, M.T. Fernández-Figueras, J. Romaní, C. Ferrándiz" "autores" => array:4 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Bassas-Vila" ] 1 => array:2 [ "nombre" => "M.T." "apellidos" => "Fernández-Figueras" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "Romaní" ] 3 => array:2 [ "nombre" => "C." 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B, Hematoxylin-eosin, original magnification ×<span class="elsevierStyleHsp" style=""></span>100. C and D, Hematoxylin-eosin, original magnification ×<span class="elsevierStyleHsp" style=""></span>200.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "P. Giavedoni, A. Barreiro-Capurro, J. Ferrando" "autores" => array:3 [ 0 => array:2 [ "nombre" => "P." "apellidos" => "Giavedoni" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Barreiro-Capurro" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "Ferrando" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731013003736" "doi" => "10.1016/j.ad.2013.10.005" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731013003736?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219014000080?idApp=UINPBA000044" "url" => "/15782190/0000010500000002/v1_201403090058/S1578219014000080/v1_201403090058/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S1578219014000250" "issn" => "15782190" "doi" => "10.1016/j.adengl.2013.03.012" "estado" => "S300" "fechaPublicacion" => "2014-03-01" "aid" => "859" "copyright" => "Elsevier España, S.L. and AEDV" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2014;105:e1-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2680 "formatos" => array:3 [ "EPUB" => 41 "HTML" => 2053 "PDF" => 586 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case Report</span>" "titulo" => "Angiolymphoid Hyperplasia With Eosinophilia: A Clinicopathologic Study of 9 Cases" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "e1" "paginaFinal" => "e6" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Hiperplasia Angiolinfoide con Eosinofilia. Estudio Clínico Patológico de 9 Casos" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 704 "Ancho" => 951 "Tamanyo" => 172684 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Erythematous papule with a superficial scab, located on the shoulder (case 4).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "R.M. Guinovart, J. Bassas-Vila, L. Morell, C. Ferrándiz" "autores" => array:4 [ 0 => array:2 [ "nombre" => "R.M." "apellidos" => "Guinovart" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Bassas-Vila" ] 2 => array:2 [ "nombre" => "L." 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Bassas-Vila, M.T. Fernández-Figueras, J. Romaní, C. Ferrándiz" "autores" => array:4 [ 0 => array:4 [ "nombre" => "J." "apellidos" => "Bassas-Vila" "email" => array:1 [ 0 => "julibassas@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "M.T." "apellidos" => "Fernández-Figueras" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "J." "apellidos" => "Romaní" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "C." "apellidos" => "Ferrándiz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Department of Dermatology, Hospital Universitari Germans Trias i Pujol, Badalona, Autonomous University of Barcelona, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Department of Pathology, Hospital Universitari Germans Trias i Pujol, Badalona, Autonomous University of Barcelona, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Department of Dermatology, Consorci Sanitari Parc Tauli, Sabadell, Autonomous University of Barcelona, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Hidradenitis ecrina infecciosa: Descripción de 3 casos y revisión de la literatura" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1195 "Ancho" => 900 "Tamanyo" => 349599 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Case 3. The epidermis and the upper dermis are essentially unremarkable. Inflammatory cells are limited to the stroma surrounding the eccrine sweat glands (hematoxylin–eosin, original magnification 40×).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Neutrophilic eccrine hidradenitis (NEH) is a rare but distinctive condition, first described by Harrist et al.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> in 1982. It typically occurs in patients undergoing chemotherapy for malignant disease. It is an inflammatory dermatosis characterized by a neutrophilic infiltrate around and within the eccrine glands. There have also been very rare reports of NEH caused by infection, a condition that has been called infectious eccrine hidradenitis (IEH). Only 6 reports documenting the presence of an infectious pathogen at the site of the skin eruption have been reported in NEH,<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2–7</span></a> and there has also been a report of a case associated with streptococcal infectious endocarditis.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">This article describes the clinical and histopathological findings of 3 cases of IEH that add strength to the hypothesis that NEH is a clinicopathological reaction pattern caused by different factors.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Three cases of histologically confirmed NEH with an infectious origin were retrieved from our files. Clinical information was obtained from hospital records or clinicians, or via laboratory request forms. The following data were recorded for each patient when available: age, sex, clinical appearance and location of the lesions, clinical diagnosis, associated diseases, and follow-up. The biopsy samples had been routinely processed (fixed in 4% or 10% neutral buffered formalin) and paraffin-embedded material had been cut into 5-μm-thick sections and examined with hematoxylin–eosin, Ziehl-Neelsen, and Gram stains.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Case Descriptions</span><p id="par0020" class="elsevierStylePara elsevierViewall">Patient 1, an 82-year-old man with disseminated nocardiosis involving the skin and the central nervous system, developed papular and nodular erythematous lesions on his arms, thighs, and ankles. Some of the lesions oozed a purulent exudate. The histopathological features were consistent with NEH and <span class="elsevierStyleItalic">Nocardia</span> species was isolated following culture of exudate. After diagnosis, despite specific antibiotic treatment, the patient's condition worsened, with progressive central nervous system impairment, and he died.</p><p id="par0025" class="elsevierStylePara elsevierViewall">Patient 2 was a 37-year-old man with human immunodeficiency virus (HIV) infection, type 2 diabetes mellitus, and Burkitt lymphoma in complete remission (nonrecent chemotherapy). He had multiple crops of papules on the legs and soles of the feet (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>), histopathological findings consistent with NEH, and a positive lesion culture for <span class="elsevierStyleItalic">Mycobacterium chelonae</span>. The recurrent skin lesions disappeared after 12 months of treatment with clarithromycin, ciprofloxacin, and cotrimoxazole. There have been no known recurrences.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">Patient 3 was a previously healthy 57-year-old man with concomitant endocarditis and meningitis. He developed papules on the abdominal skin and had histopathologic findings of NEH and a lesion culture that was positive for <span class="elsevierStyleItalic">Staphylococcus aureus</span>. He died of septic complications.</p><p id="par0035" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> summarizes the clinical data of the 3 patients and the cases described in the literature.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Histopathological Findings</span><p id="par0040" class="elsevierStylePara elsevierViewall">Punch biopsies and microscopic examination revealed similar features in the 3 cases. The epidermis was essentially normal. There was a dense perivascular and periductal infiltrate of neutrophils in the dermis with duct infiltration. In the eccrine glands, there was vacuolar degeneration and necrosis of the epithelial cells, predominantly in the secretory portion. Microabscess formation was also seen in this portion (<a class="elsevierStyleCrossRefs" href="#fig0010">Figs. 2 and 3</a>). Vascular damage adjacent to neutrophilic abscesses was identified in patients 1 and 2. Ziehl-Neelsen and Gram staining revealed branching, beaded, filamentous, gram-positive bacteria with morphologic features of <span class="elsevierStyleItalic">Nocardia</span> species in patient 1 and gram-positive cocci in the lumen of the eccrine sweat gland coil in patient 3. In addition, tissue culture confirmed the presence of <span class="elsevierStyleItalic">Nocardia</span> species in patient 1, <span class="elsevierStyleItalic">M. chelonae</span> in patient 2, and <span class="elsevierStyleItalic">S. aureus</span> in patient 3.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> summarizes the histopathological features of the 3 cases and the cases described in literature.</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Discussion</span><p id="par0050" class="elsevierStylePara elsevierViewall">Although NEH usually affects patients with hematologic malignancies undergoing chemotherapy,<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,9</span></a> this neutrophilic dermatosis has also been reported in association with nonchemotherapeutic agents,<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">10,11</span></a> in immunocompromised persons,<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">12,13</span></a> and in patients who later develop leukemia.<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">14,15</span></a> It has only occasionally been associated with infection.</p><p id="par0055" class="elsevierStylePara elsevierViewall">Clinical manifestations include erythematous papules, small nodules, plaques, pustules, purpura, and urticaria. The presence of an infectious pathogen at the site of the skin eruption has only been reported in 6 cases<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2–7</span></a> and there has also been a report of NEH occurring in association with streptococcal infectious endocarditis with a negative skin tissue culture and a positive blood culture.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> IEH is rare and, as occurred in our 3 cases, most of the cases reported have documented an infectious pathogen at the site of the skin eruption as well as a concomitant and/or associated infectious disease.</p><p id="par0060" class="elsevierStylePara elsevierViewall">IEH was first described in 1985 by Moreno et al.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> in a patient with chronic renal failure on hemodialysis who experienced recurrent crops of erythematous papules on his extremities over the course of 3 years. The authors suggested that altered immunity might have facilitated infection by <span class="elsevierStyleItalic">Serratia</span> species, a common cause of nosocomial infection. There has also been another report of <span class="elsevierStyleItalic">Serratia</span>-related IEH in a patient previously operated on for ependymoma, with recurrence of the disease on 3 occasions.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> The same bacterium (<span class="elsevierStyleItalic">Serratia marcescens</span>) was isolated on each occasion and the disease remitted after antibiotic therapy. IEH has since been reported in an otherwise healthy man who had not received chemotherapy.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> In that case, the infectious agent was <span class="elsevierStyleItalic">Enterobacter cloacae</span>. Gram-positive cocci were found in the lesional eccrine duct in another case<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> and there has also been a report of <span class="elsevierStyleItalic">Staphylococcus aureus</span> infection in an immunosuppressed man on ciclosporin therapy following a heart transplant.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">To the best of our knowledge, only 1 case of IEH with <span class="elsevierStyleItalic">Nocardia asteroides</span> infection has been reported.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The patient had multiple, tender, erythematous plaques and nodules on her right thigh and the infectious agent was detected histologically in the eccrine ductal epithelium and subsequently identified by tissue culture. She was treated with trimethoprim-sulfamethoxazole, with complete resolution of the skin lesions in 3 weeks. In our case of IEH secondary to <span class="elsevierStyleItalic">Nocardia</span> species, the patient developed nodular erythematous lesions, some of which oozed a purulent exudate, on the arms, thighs, and ankles. Despite specific antibiotic treatment with trimethoprim-sulfamethoxazole and supportive care, the patient's condition worsened and he died following progressive central nervous system impairment.</p><p id="par0070" class="elsevierStylePara elsevierViewall">We have described 3 cases of IEH secondary to <span class="elsevierStyleItalic">Nocardia</span> species, <span class="elsevierStyleItalic">M chelonae</span>, and <span class="elsevierStyleItalic">S aureus</span>. In each of the cases, the bacteria were isolated by skin lesion tissue culture. The clinical manifestations of IEH include infiltrated, erythematous papules, small nodules, plaques, pustules, purpura, and urticaria and the presentation is similar to that seen in NEH caused by other factors.</p><p id="par0075" class="elsevierStylePara elsevierViewall">Although not obviously within the category of IEH, HIV infection has been associated with the development of classic NEH.<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">12,13</span></a> The eruptions may have been the result of HIV therapy or infectious pathogens, although repeated blood and skin cultures were negative. One of our patients (case 2) also had HIV infection. He had recurrent eruptions and was not receiving antiviral therapy at the time of these eruptions. <span class="elsevierStyleItalic">M. chelonae</span> was isolated from the skin lesions.</p><p id="par0080" class="elsevierStylePara elsevierViewall">In addition to the characteristic histological features reported in the literature, in our 3 cases we also saw considerable vascular damage, adjacent to neutrophilic abscesses in patients 1 and 2.</p><p id="par0085" class="elsevierStylePara elsevierViewall">Histopathological findings of infectious and noninfectious NEH are generally indistinguishable and when NEH is suspected, the possibility of an infectious origin must be considered and investigated by skin tissue culture. Although the absence of metaplasia might be taken as a clue to an infectious origin, we found the presence or absence of syringometaplasia to have no bearing on either of our cases or on those in the literature reviewed.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2–7</span></a> Further specific studies are necessary to investigate the significance and etiology of metaplasia in NEH.</p><p id="par0090" class="elsevierStylePara elsevierViewall">The final outcomes in our cases support the assertion that NEH is a characteristic cutaneous response to nonspecific stimuli and should be included in the differential diagnosis of a spectrum of clinical presentations. An infectious cause should be ruled out with appropriate cultures in all cases of NEH. In case 1, our patient developed secondary cerebral abscesses, probably caused by <span class="elsevierStyleItalic">Nocardia</span> species, and died. In case 3, the patient developed an infectious endocarditis with staphylococcal sepsis and also died. We were unable to assess the outcome of the skin lesions after the introduction of adequate treatment in these 2 cases. Patient 2, however, was treated with antibiotics for 12 months and experienced complete resolution of skin lesions.</p><p id="par0095" class="elsevierStylePara elsevierViewall">We agree with the previously published observation that it is not possible to distinguish IEH from noninfectious cases on the basis of clinical and microscopic findings.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> In particular, the case of our second patient, who had HIV infection and no other manifestations of infectious disease, shows how important it is to rule out the presence of an infectious agent with appropriate cultures in all cases of NEH.</p><p id="par0100" class="elsevierStylePara elsevierViewall">Even though infectious etiology is very rare in NEH, we believe that it should be explored in patients with histopathological findings of NEH who are at risk for nosocomial infections, as appropriate antibiotic treatment could be beneficial. Finally, NEH should be considered in the differential diagnosis of a wide variety of clinical settings and histopathological findings.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Ethical Disclosures</span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Protection of Human and Animal Subjects</span><p id="par0105" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this investigation.</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Confidentiality of Data</span><p id="par0110" class="elsevierStylePara elsevierViewall">The authors declare that they have followed the protocols of their work centre on the publication of patient data and that all the patients included in the study have received sufficient information and have given their informed consent in writing to participate in this study.</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Right to Privacy and Informed Consent</span><p id="par0115" class="elsevierStylePara elsevierViewall">The authors have obtained the informed consent of the patients and/or subjects mentioned in the article and the author for correspondence is in possession of this documentation.</p></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Conflicts of Interest</span><p id="par0120" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:10 [ 0 => array:2 [ "identificador" => "xres318973" "titulo" => "Abstract" ] 1 => array:2 [ "identificador" => "xpalclavsec301762" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "xres318974" "titulo" => "Resumen" ] 3 => array:2 [ "identificador" => "xpalclavsec301761" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:3 [ "identificador" => "sec0010" "titulo" => "Case Descriptions" "secciones" => array:1 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Histopathological Findings" ] ] ] 6 => array:2 [ "identificador" => "sec0020" "titulo" => "Discussion" ] 7 => array:3 [ "identificador" => "sec0025" "titulo" => "Ethical Disclosures" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0030" "titulo" => "Protection of Human and Animal Subjects" ] 1 => array:2 [ "identificador" => "sec0035" "titulo" => "Confidentiality of Data" ] 2 => array:2 [ "identificador" => "sec0040" "titulo" => "Right to Privacy and Informed Consent" ] ] ] 8 => array:2 [ "identificador" => "sec0045" "titulo" => "Conflicts of Interest" ] 9 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2012-10-23" "fechaAceptado" => "2013-04-01" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec301762" "palabras" => array:3 [ 0 => "Infectious" 1 => "Eccrine hidradenitis" 2 => "Sweat gland" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec301761" "palabras" => array:3 [ 0 => "Infeccioso" 1 => "Hidradenitis ecrina" 2 => "Glándula sudorípara" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Neutrophilic eccrine hidradenitis (NEH) is a nonspecific clinicopathological reaction pattern, classified as a neutrophilic dermatosis, that usually develops in patients receiving chemotherapy for a hematologic malignancy. More rarely, it has been reported in association with infectious agents such as <span class="elsevierStyleItalic">Serratia</span> and <span class="elsevierStyleItalic">Enterobacter</span> species, <span class="elsevierStyleItalic">Staphylococcus aureus</span>, and human immunodeficiency virus.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We describe 3 cases of infectious eccrine hidradenitis secondary to infection with <span class="elsevierStyleItalic">Nocardia</span> species, <span class="elsevierStyleItalic">Mycobacterium chelonae</span>, and <span class="elsevierStyleItalic">S aureus</span>.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Histological findings revealed a dense infiltrate with perivascular and periductal neutrophils in the dermis. In the eccrine glands, there was vacuolar degeneration and necrosis of the epithelial cells.</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Our cases support the assertion that NEH is a characteristic cutaneous response to nonspecific stimuli. Clinical and histopathological findings of infectious and noninfectious NEH are generally indistinguishable and when NEH is suspected, the possibility of an infectious association must be investigated by skin tissue culture. In this article we also discuss differential diagnoses and review the literature.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La hidradenitis ecrina neutrofílica (HEN) es un patrón de reacción clínico-patológico inespecífico, que se ha clasificado como una dermatosis neutrofílica. Normalemente se ha descrito asociada a una enfermedad hematológica maligna. En algunas ocasiones se ha publicado la hidradenitis ecrina neutrofílica asociada a un microorganismo como <span class="elsevierStyleItalic">Serratia</span>, <span class="elsevierStyleItalic">Enterobacter</span>, <span class="elsevierStyleItalic">Staphylococcus</span> y VIH.</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Nosotros describimos 3 casos de hidradenitis ecrina infecciosa secundarias a infecciones por <span class="elsevierStyleItalic">Nocardia</span>, <span class="elsevierStyleItalic">Mycobacterium chelonae</span> y <span class="elsevierStyleItalic">Staphylococcus aureus</span>. Las biopsias mostraron un denso infiltrado perivascular y periductal de neutrófilos en la dermis. En las glándulas ecrinas se apreciaba degeneración vacuolar y necrosis de las células epiteliales, predominantemente en la porción secretora.</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Nuestros casos apoyan que la HEN es una respuesta cutánea característica a un estímulo inespecífico. Los hallazgos clínicos e histopatológicos de la HEN infecciosa o no infecciosa son generalmente indistinguibles. Cuando se considera un caso de HEN se debería investigar la posibilidad de una causa infecciosa y realizar un cultivo.</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">En este artículo hemos revisado los diagnósticos diferenciales clínicos e histopatológicos y la literatura publicada de esta entidad.</p>" ] ] "multimedia" => array:5 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 749 "Ancho" => 1000 "Tamanyo" => 103912 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Case 2. Detail of erythematous papules.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1195 "Ancho" => 900 "Tamanyo" => 349599 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Case 3. The epidermis and the upper dermis are essentially unremarkable. Inflammatory cells are limited to the stroma surrounding the eccrine sweat glands (hematoxylin–eosin, original magnification 40×).</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 753 "Ancho" => 1000 "Tamanyo" => 292405 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Case 3. A polymorphous dense neutrophilic, lymphocytic, and histiocytic infiltrate surrounding the eccrine secretory coils, leading to vacuolar degeneration and necrosis of eccrine epithelial cells (hematoxylin–eosin, original magnification 400×).</p>" ] ] 3 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Abbreviations: COPD, chronic obstructive pulmonary disease; HIV, human immunodeficiency virus; ND, not described.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Case \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Sex \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Age, y/o \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Clinical Features \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Lesion Site \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Pathogens \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Associated Diseases or Findings \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Follow-up \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Case 1 (present series) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">M \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">82 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Papules, nodules \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Arms, thigh, ankles \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Nocardia</span> species \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Demyelinating neuropathy \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Deceased \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Case 2 (present series) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">M \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">37 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Papules \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Legs, soles of feet \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Mycobacterium chelonae</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Diabetes, HIV infection, lymphoma \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Resolution of lesions \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Case 3 (present series) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">M \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">57 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Papules \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Abdominal skin \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Staphylococcus aureus</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">None \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Deceased \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Oono et al.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">F \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">71 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Papules, small pustules \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Chest, upper back, arms \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Gram-positive cocci \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Bullous pemphigoid \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">ND \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Antonovich et al.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">F \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">83 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Plaques, nodules \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Thigh \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Nocardia</span> species \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">COPD, mitral valve prolapse, breast and endometrial cancer \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Resolution of lesions \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Combemale et al.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">M \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">31 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Papules \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Lower legs, thigh, abdomen \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Serratia marcescens</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Low-grade spinal ependymoma \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">ND \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Taira et al.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">M \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">47 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Papules \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Left wrist \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">S aureus</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Heart transplant \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Resolution of lesions \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Allegue et al.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">M \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">47 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Papules, pustules \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Forearm, thigh, abdomen, ankle \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Enterobacter cloacae</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">None \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Resolution of lesions \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Moreno et al.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">M \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">48 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Papules \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Arms, legs \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Serratia</span> species \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Renal failure and hemodialysis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">ND \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab465393.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Clinical Data of 3 Patients With Infectious Neutrophilic Eccrine Hidradenitis and Summary of Cases Described in the Literature.</p>" ] ] 4 => array:7 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Abbreviation: ND, not described.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Case \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Infiltrate \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Findings in the Eccrine Glands \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Abscesses \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Vessels \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Eccrine Syringometaplasia \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Case 1 (our series) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Dense infiltrate with perivascular and periductal neutrophils \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Vacuolar degeneration and necrosis of the epithelial cells, predominantly in the secretory portion \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Microabscesses in the secretory portion \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Vascular damage adjacent to neutrophilic abscesses \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">None \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Case 2 (our series) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Dense infiltrate with perivascular and periductal neutrophils \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Vacuolar degeneration and necrosis of the epithelial cells, predominantly in the secretory portion \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Microabscesses in the secretory portion \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Vascular damage adjacent to neutrophilic abscesses \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">None \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Case 3 (our series) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Dense infiltrate with perivascular and periductal neutrophils \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Vacuolar degeneration and necrosis of the epithelial cells, predominantly in the secretory portion \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Microabscesses in the secretory portion \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Inflammatory infiltrate around the blood vessels \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">None \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Oono et al.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Mild perivascular and periductal inflammatory infiltrate of lymphoid cells and neutrophils \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Vacuolar degeneration and necrosis of the epithelial cells (in the intradermal eccrine duct) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Microabscesses in the lumen of the intradermal eccrine duct, acrosyringium, and secretory portion of the eccrine glands \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">ND \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">ND \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Antonovich et al.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">A sparse superficial and deep perivascular and interstitial polymorphous infiltrate of neutrophils, lymphocytes, and histiocytes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Neutrophils around and infiltrating the dermal eccrine ducts with extension in the ductal lumina \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Luminal abscesses \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">ND \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">ND \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Combemale et al.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Vessels surrounded by a dense infiltrate of pyknotic neutrophils \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Focal necrosis of eccrine secretory coils extending to the excretory ducts and to adjacent blood vessels \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">ND \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Infiltrate extending to adjacent vessels, not hair follicles \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">ND \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Taira et al.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Neutrophils and lymphocytes within the connective tissue stroma of the eccrine glands \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Degenerative changes with cytoplasmic vacuolar alteration and nuclear pyknosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Exocytotic neutrophils within the glandular epithelium \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">ND \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">ND \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Allegue et al.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Dense, predominantly neutrophilic inflammatory infiltrate around the eccrine coils \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Vacuolar degeneration and focal epithelial cell necrosis in the secretory coil epithelium \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Microabscesses in the secretory coil \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Erythrocyte extravasation \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Squamous metaplasia \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Moreno et al.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Dense neutrophilic inflammatory infiltrate around the small vessels, eccrine sweat gland coils, ducts, and upper subcutaneous fat \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Swollen epithelial sweat gland cells \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Intraglandular microabscesses \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Inflammatory infiltrate around the blood vessels \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">ND \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab465392.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Summary of Histopathological Features of Infectious Neutrophilic Eccrine Hidradenitis in Our 3 Patients and the Cases Described in the Literature.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:15 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neutrophilic eccrine hidradenitis. 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Year/Month | Html | Total | |
---|---|---|---|
2024 November | 7 | 14 | 21 |
2024 October | 94 | 38 | 132 |
2024 September | 103 | 32 | 135 |
2024 August | 120 | 68 | 188 |
2024 July | 108 | 64 | 172 |
2024 June | 94 | 59 | 153 |
2024 May | 91 | 36 | 127 |
2024 April | 79 | 28 | 107 |
2024 March | 70 | 37 | 107 |
2024 February | 106 | 25 | 131 |
2024 January | 82 | 38 | 120 |
2023 December | 82 | 25 | 107 |
2023 November | 92 | 40 | 132 |
2023 October | 114 | 29 | 143 |
2023 September | 83 | 30 | 113 |
2023 August | 61 | 23 | 84 |
2023 July | 111 | 37 | 148 |
2023 June | 79 | 26 | 105 |
2023 May | 66 | 28 | 94 |
2023 April | 71 | 33 | 104 |
2023 March | 48 | 38 | 86 |
2023 February | 53 | 25 | 78 |
2023 January | 47 | 27 | 74 |
2022 December | 49 | 45 | 94 |
2022 November | 22 | 29 | 51 |
2022 October | 19 | 20 | 39 |
2022 September | 29 | 49 | 78 |
2022 August | 26 | 38 | 64 |
2022 July | 31 | 31 | 62 |
2022 June | 32 | 39 | 71 |
2022 May | 65 | 31 | 96 |
2022 April | 70 | 33 | 103 |
2022 March | 68 | 36 | 104 |
2022 February | 54 | 30 | 84 |
2022 January | 56 | 35 | 91 |
2021 December | 44 | 50 | 94 |
2021 November | 58 | 40 | 98 |
2021 October | 55 | 48 | 103 |
2021 September | 51 | 43 | 94 |
2021 August | 64 | 44 | 108 |
2021 July | 56 | 40 | 96 |
2021 June | 44 | 42 | 86 |
2021 May | 47 | 46 | 93 |
2021 April | 148 | 96 | 244 |
2021 March | 102 | 28 | 130 |
2021 February | 63 | 30 | 93 |
2021 January | 64 | 15 | 79 |
2020 December | 52 | 14 | 66 |
2020 November | 36 | 15 | 51 |
2020 October | 46 | 4 | 50 |
2020 September | 31 | 21 | 52 |
2020 August | 49 | 18 | 67 |
2020 July | 45 | 20 | 65 |
2020 June | 32 | 29 | 61 |
2020 May | 26 | 21 | 47 |
2020 April | 42 | 16 | 58 |
2020 March | 29 | 25 | 54 |
2020 February | 7 | 7 | 14 |
2020 January | 4 | 4 | 8 |
2019 December | 8 | 5 | 13 |
2019 November | 4 | 3 | 7 |
2019 October | 0 | 4 | 4 |
2019 September | 8 | 11 | 19 |
2019 August | 4 | 2 | 6 |
2019 July | 4 | 1 | 5 |
2019 June | 6 | 8 | 14 |
2019 May | 4 | 0 | 4 |
2019 April | 2 | 2 | 4 |
2019 March | 2 | 7 | 9 |
2019 February | 2 | 2 | 4 |
2019 January | 4 | 0 | 4 |
2018 December | 1 | 2 | 3 |
2018 November | 2 | 2 | 4 |
2018 October | 4 | 1 | 5 |
2018 September | 3 | 0 | 3 |
2018 March | 2 | 1 | 3 |
2018 February | 58 | 4 | 62 |
2018 January | 61 | 9 | 70 |
2017 December | 56 | 7 | 63 |
2017 November | 48 | 4 | 52 |
2017 October | 47 | 6 | 53 |
2017 September | 36 | 10 | 46 |
2017 August | 53 | 10 | 63 |
2017 July | 54 | 13 | 67 |
2017 June | 69 | 6 | 75 |
2017 May | 51 | 9 | 60 |
2017 April | 46 | 12 | 58 |
2017 March | 42 | 13 | 55 |
2017 February | 41 | 11 | 52 |
2017 January | 24 | 8 | 32 |
2016 December | 33 | 11 | 44 |
2016 November | 52 | 12 | 64 |
2016 October | 65 | 22 | 87 |
2016 September | 158 | 8 | 166 |
2016 August | 124 | 8 | 132 |
2016 July | 47 | 7 | 54 |
2016 June | 14 | 5 | 19 |
2016 May | 4 | 7 | 11 |
2016 April | 3 | 0 | 3 |
2016 March | 5 | 0 | 5 |
2016 February | 8 | 2 | 10 |
2016 January | 8 | 8 | 16 |
2015 December | 7 | 9 | 16 |
2015 November | 14 | 10 | 24 |
2015 October | 13 | 4 | 17 |
2015 September | 3 | 2 | 5 |
2015 August | 6 | 2 | 8 |
2015 July | 27 | 3 | 30 |
2015 June | 19 | 0 | 19 |
2015 May | 34 | 2 | 36 |
2015 April | 14 | 6 | 20 |
2015 March | 16 | 1 | 17 |
2015 February | 11 | 4 | 15 |
2015 January | 12 | 4 | 16 |
2014 December | 14 | 2 | 16 |
2014 November | 7 | 4 | 11 |
2014 October | 21 | 7 | 28 |
2014 September | 6 | 6 | 12 |
2014 August | 3 | 2 | 5 |
2014 July | 3 | 4 | 7 |
2014 June | 5 | 5 | 10 |
2014 May | 9 | 4 | 13 |
2014 April | 2 | 2 | 4 |
2014 March | 4 | 7 | 11 |