array:24 [
  "pii" => "S1578219014000316"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2013.02.017"
  "estado" => "S300"
  "fechaPublicacion" => "2014-03-01"
  "aid" => "824"
  "copyright" => "Elsevier España, S.L. and AEDV"
  "copyrightAnyo" => "2012"
  "documento" => "simple-article"
  "crossmark" => 0
  "subdocumento" => "cor"
  "cita" => "Actas Dermosifiliogr. 2014;105:202-3"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 2112
    "formatos" => array:3 [
      "EPUB" => 45
      "HTML" => 1429
      "PDF" => 638
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0001731013001075"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2013.02.010"
      "estado" => "S300"
      "fechaPublicacion" => "2014-03-01"
      "aid" => "824"
      "copyright" => "Elsevier España, S.L. y AEDV"
      "documento" => "simple-article"
      "crossmark" => 0
      "subdocumento" => "cor"
      "cita" => "Actas Dermosifiliogr. 2014;105:202-3"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 5291
        "formatos" => array:3 [
          "EPUB" => 3
          "HTML" => 2911
          "PDF" => 2377
        ]
      ]
      "es" => array:10 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta cient&#237;fico-cl&#237;nica</span>"
        "titulo" => "Sevoflurano&#44; &#191;una alternativa en el tratamiento de las &#250;lceras vasculares&#63;"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "202"
            "paginaFinal" => "203"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Sevoflurane&#58; A Valid Alternative for the Treatment of Vascular Ulcers&#63;"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "R&#46;F&#46; Lafuente-Urrez, Y&#46; Gilaberte"
            "autores" => array:2 [
              0 => array:2 [
                "nombre" => "R&#46;F&#46;"
                "apellidos" => "Lafuente-Urrez"
              ]
              1 => array:2 [
                "nombre" => "Y&#46;"
                "apellidos" => "Gilaberte"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219014000316"
          "doi" => "10.1016/j.adengl.2013.02.017"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219014000316?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731013001075?idApp=UINPBA000044"
      "url" => "/00017310/0000010500000002/v1_201403120205/S0001731013001075/v1_201403120205/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1578219014000274"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2013.02.015"
    "estado" => "S300"
    "fechaPublicacion" => "2014-03-01"
    "aid" => "808"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2014;105:204-6"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2965
      "formatos" => array:3 [
        "EPUB" => 42
        "HTML" => 2515
        "PDF" => 408
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
      "titulo" => "Disseminated Sporotrichosis With Cutaneous and Testicular Involvement"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "204"
          "paginaFinal" => "206"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Esporotricosis diseminada con afecci&#243;n cut&#225;nea y testicular"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 857
              "Ancho" => 1500
              "Tamanyo" => 189235
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A&#44; PAS-stained smear showing cigar-shaped yeast cells &#40;original magnification &#215;100&#41;&#46; B&#44; Microscopic analysis of the culture showing sympodial conidia &#40;lactophenol blue&#44; original magnification &#215;40&#41;&#46; C&#44; Culture of <span class="elsevierStyleItalic">Sporothrix</span> species&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "C&#46;J&#46; Espinoza-Hern&#225;ndez, A&#46; Jes&#250;s-Silva, S&#46; Toussaint-Caire, R&#46; Arenas"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "C&#46;J&#46;"
              "apellidos" => "Espinoza-Hern&#225;ndez"
            ]
            1 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Jes&#250;s-Silva"
            ]
            2 => array:2 [
              "nombre" => "S&#46;"
              "apellidos" => "Toussaint-Caire"
            ]
            3 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Arenas"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731013000616"
        "doi" => "10.1016/j.ad.2013.02.002"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731013000616?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219014000274?idApp=UINPBA000044"
    "url" => "/15782190/0000010500000002/v1_201403090058/S1578219014000274/v1_201403090058/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1578219014000328"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2013.03.013"
    "estado" => "S300"
    "fechaPublicacion" => "2014-03-01"
    "aid" => "849"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2014;105:200-2"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1705
      "formatos" => array:3 [
        "EPUB" => 47
        "HTML" => 1319
        "PDF" => 339
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
      "titulo" => "Restoration of Response to Ustekinumab With Narrowband UV-B Phototherapy"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "200"
          "paginaFinal" => "202"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Recuperaci&#243;n de la respuesta a ustekinumab mediante fototerapia con ultravioleta B de banda estrecha"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 727
              "Ancho" => 1001
              "Tamanyo" => 132845
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A&#44; Patient 1&#46; Recurrence of psoriasis 30 weeks after initiation of ustekinumab &#40;PASI&#44; 9&#46;8&#41;&#46; B&#44; Patient 1&#46; PASI 75 after combining 17 sessions of narrowband UV-B therapy &#40;12&#46;9<span class="elsevierStyleHsp" style=""></span>J&#47;cm<span class="elsevierStyleSup">2</span>&#41; with ustekinumab &#40;PASI&#44; 2&#46;1&#41;&#46; PASI indicates Psoriasis Area and Severity Index&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "P&#46; Soro Mart&#237;nez, I&#46; Belinch&#243;n Romero, M&#46;P&#46; Arribas Granados"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Soro Mart&#237;nez"
            ]
            1 => array:2 [
              "nombre" => "I&#46;"
              "apellidos" => "Belinch&#243;n Romero"
            ]
            2 => array:2 [
              "nombre" => "M&#46;P&#46;"
              "apellidos" => "Arribas Granados"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S000173101300207X"
        "doi" => "10.1016/j.ad.2013.03.007"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S000173101300207X?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219014000328?idApp=UINPBA000044"
    "url" => "/15782190/0000010500000002/v1_201403090058/S1578219014000328/v1_201403090058/en/main.assets"
  ]
  "en" => array:13 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
    "titulo" => "Sevoflurane&#58; A Valid Alternative for the Treatment of Vascular Ulcers&#63;"
    "tieneTextoCompleto" => true
    "saludo" => "<span class="elsevierStyleItalic">To the Editor&#58;</span>"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "202"
        "paginaFinal" => "203"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "R&#46;F&#46; Lafuente-Urrez, Y&#46; Gilaberte"
        "autores" => array:2 [
          0 => array:4 [
            "nombre" => "R&#46;F&#46;"
            "apellidos" => "Lafuente-Urrez"
            "email" => array:2 [
              0 => "fati1997&#64;gmail&#46;com"
              1 => "rfz97&#64;yahoo&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Y&#46;"
            "apellidos" => "Gilaberte"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital Reina Sof&#237;a&#44; Tudela&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital San Jorge&#44; Huesca&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Sevoflurano&#44; &#191;una alternativa en el tratamiento de las &#250;lceras vasculares&#63;"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Vascular ulcers are a major health problem because of their frequency&#44; chronic nature&#44; and high recurrence rate&#46; The standard treatment&#44; which consists of cleansing&#44; debridement&#44; and application of dressings&#44; achieves cure rates of 65&#37; to 85&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The approaches used to accelerate scarring of these ulcers include dressings &#40;biologic&#44; synthetic&#44; or biosynthetic&#41;&#44; human amniotic membrane transplantation&#44;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> and autologous platelet-rich plasma&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Options for analgesia to control the pain associated with vascular ulcers include topical anesthetics such as the creams Emla &#40;lidocaine and prilocaine&#41; and Lambdalina &#40;lidocaine&#41;&#44; oral analgesics&#44; and even opiates&#46; These products aid in the healing process and in pain control&#44; although they can produce undesirable effects&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Sevoflurane is an inhaled general anesthetic from the halogenated ether family that is indicated for induction and maintenance of general anesthesia during hospital or outpatient surgery&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Its analgesic effect is both central<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> and peripheral&#44;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5-7</span></a> although it has traditionally been thought that halogenated anesthetics lack a peripheral analgesic effect&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Topical sevoflurane has been reported to be effective in the treatment of long-standing venous ulcers<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> and ischemic ulcers<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> that are refractory to standard treatment&#59; when irrigated topically over the painful ulcer bed&#44; it produces a rapid&#44; intense&#44; and lasting analgesic effect&#44; with a suitable safety profile that is well accepted by patients&#46; In addition&#44; it significantly reduces the size of the ulcer and the time necessary for epithelialization&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5-7</span></a> Its effect can be so intense that it is even possible to perform surgical debridement without the need for further analgesia&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Similarly&#44; it has been suggested that direct application of sevoflurane has an antimicrobial effect on ulcers that are superinfected by multiresistant <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span>&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> and a bactericidal effect has been reported in vitro against <span class="elsevierStyleItalic">Staphylococcus aureus</span>&#44; <span class="elsevierStyleItalic">P&#46; aeruginosa</span>&#44; and <span class="elsevierStyleItalic">Escherichia coli</span>&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Sevoflurane &#40;Sevorane&#41; is marketed as a colorless volatile liquid with no additives or preservatives in a 250-mL amber-colored polyethylene naphthalate bottle with a safety cap and a filling adapter&#46; Each milliliter of liquid contains 1<span class="elsevierStyleHsp" style=""></span>mL of sevoflurane &#40;INN&#41;&#46; It should be kept at room temperature and protected from sunlight&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Once the ulcer has been cleansed with saline solution&#44; sevoflurane is applied directly on the ulcer bed&#44; ensuring that the liquid is distributed throughout the tissue and taking care that it does not come into contact with the surrounding healthy skin&#46; It is necessary to wait 2<span class="elsevierStyleHsp" style=""></span>minutes before applying standard wound care<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;7</span></a> and placing the dressing&#46; A compression bandage should also be applied when necessary&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">To date&#44; 12 patients have been treated with topical sevoflurane&#44; and 2 of these cases have been published&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a> The case of an immunodepressed patient with a postsurgical wound superinfected by multiresistant <span class="elsevierStyleItalic">P&#46; aeruginosa</span> who was cured after several applications of sevoflurane is pending publication&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> At the 17<span class="elsevierStyleSup">th</span> Annual Meeting of the European Society of Regional Anesthesia in Barcelona in October 2011&#44; a series of 9 patients was presented &#40;6 women and 3 men with diabetes&#41;&#46; The patients had painful venous ulcers on the lower limbs that were refractory to regular analgesics and were treated with sevoflurane on an outpatient basis to control the pain&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> In all cases&#44; the reduction in pain at rest was rapid &#40;less than 2 minutes&#41;&#44; intense &#40;7&#46;4<span class="elsevierStyleHsp" style=""></span>&#91;0&#46;5&#93; to 2&#46;1<span class="elsevierStyleHsp" style=""></span>&#91;0&#46;6&#93; points with the first application and 7&#46;2<span class="elsevierStyleHsp" style=""></span>&#91;1&#46;3&#93; to 1&#46;1<span class="elsevierStyleHsp" style=""></span>&#91;0&#46;6&#93; points with all of the remaining 67 applications&#41;&#44; and lasting &#40;from 7 to 16<span class="elsevierStyleHsp" style=""></span>hours&#41;&#46; The ulcers were cured in 4 cases&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">The risk-benefit ratio of sevoflurane has proven very favorable to date&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;7</span></a> The only undesirable effects of topical application are pruritus at the borders of the wound and irritation of the surrounding skin with repeated applications&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Sevoflurane has not been reported to have sensitizing potential&#46; Similarly&#44; local irrigation with sevoflurane was well tolerated in patients with heart disease&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5-7</span></a> Systemic absorption of sevoflurane applied to an ulcer involving circulatory compromise is thought to be slow and incomplete&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> although blood levels have not been measured in patients treated with this procedure&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The mechanism underlying the analgesic&#44; epithelializing&#44; and antimicrobial effects of sevoflurane remains unknown&#46; Inhaled sevoflurane has no peripheral analgesic effect<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a>&#59; however&#44; topical or subcutaneous administration does produce a peripheral effect&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> When a halogenated agent is inhaled&#44; the partial pressure reached in the peripheral nociceptors may not be sufficient to block transmission of a painful stimulus&#59; however&#44; with direct application&#44; the nociceptors are exposed to sufficient partial pressure to block transmission of painful stimuli&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">In conclusion&#44; topical sevoflurane could prove to be a promising strategy for analgesia and epithelialization in the treatment of vascular ulcers&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Lafuente-Urrez RF&#44; Gilaberte Y&#46; Sevoflurano&#44; &#191;una alternativa en el tratamiento de las &#250;lceras vasculares&#63;&#46; Actas Dermosifiliogr&#46; 2014&#59;105&#58;202&#8211;203&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:10 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Aplicaci&#243;n de membrana amni&#243;tica en el tratamiento de las &#250;lceras cr&#243;nicas de extremidades inferiores"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46; Alsina-Gibert"
                            1 => "S&#46; Pedregosa-Fauste"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ad.2012.01.010"
                      "Revista" => array:7 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2012"
                        "volumen" => "103"
                        "paginaInicial" => "608"
                        "paginaFinal" => "613"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22578292"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0140673612613439"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tratamiento de &#250;lceras cut&#225;neas cr&#243;nicas con plasma aut&#243;logo rico en plaquetas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "I&#46; Bur&#243;n"
                            1 => "A&#46; Fern&#225;ndez-Tresguerres"
                            2 => "M&#46; Calvo"
                            3 => "F&#46; Alfageme"
                            4 => "C&#46; Villega"
                            5 => "R&#46; Fern&#225;ndez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Piel"
                        "fecha" => "2012"
                        "volumen" => "27"
                        "paginaInicial" => "429"
                        "paginaFinal" => "434"
                        "itemHostRev" => array:3 [
                          "pii" => "S0140673605675733"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Abbott&#44; FT-4456&#46; 2006&#46; Ficha t&#233;cnica del producto &#40;Sevorane&#174;&#41;&#46;"
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of propofol and sevoflurane on the excitability of rat spinal motoneurones and nociceptive reflexes in vitro"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "E&#46; Matute"
                            1 => "I&#46; Rivera-Arconada"
                            2 => "J&#46;A&#46; L&#243;pez-Garc&#237;a"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/bja/aeh217"
                      "Revista" => array:7 [
                        "tituloSerie" => "Br J Anaesth"
                        "fecha" => "2004"
                        "volumen" => "93"
                        "paginaInicial" => "422"
                        "paginaFinal" => "427"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15277303"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0140673602119118"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Analgesic effect of topical sevoflurane on venous ulcer intractable pain"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Ger&#243;nimo-Pardo"
                            1 => "A&#46; Mart&#237;nez-Monsalve"
                            2 => "M&#46; Mart&#237;nez-Serrano"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Phlebologie"
                        "fecha" => "2011"
                        "volumen" => "40"
                        "paginaInicial" => "95"
                        "paginaFinal" => "97"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sevoflurano como anest&#233;sico local en herida isqu&#233;mica de paciente cardi&#243;pata con insuficiencia respiratoria secundaria a morfina"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; Martinez Monsalve"
                            1 => "M&#46; Ger&#243;nimo Pardo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Heridas y cicatrizaci&#243;n"
                        "fecha" => "2011"
                        "volumen" => "6"
                        "paginaInicial" => "46"
                        "paginaFinal" => "49"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Usos alternativos del sevoflurano&#46; Efecto analg&#233;sico t&#243;pico"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Ger&#243;nimo Pardo"
                            1 => "M&#46; Martinez Serrano"
                            2 => "A&#46; Mart&#237;nez Molsalve"
                            3 => "J&#46;L&#46; Rueda Mart&#237;nez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Rev Electron Anestesia R"
                        "fecha" => "2012"
                        "volumen" => "4"
                        "paginaInicial" => "181"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Potency &#40;minimum alveolar anesthetic concentration&#41; of isoflurane is independent of peripheral anesthetic effects"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;F&#46; Antognini"
                            1 => "N&#46;D&#46; Kien"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Anesth Analg"
                        "fecha" => "1995"
                        "volumen" => "81"
                        "paginaInicial" => "69"
                        "paginaFinal" => "72"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7598285"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0140673612613439"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Actividad bactericida del sevoflurano frente a <span class="elsevierStyleItalic">Stafilococcus aureus&#44; Pseudomonas aeruginosa</span> y <span class="elsevierStyleItalic">Escherichia coli</span>"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Mart&#237;nez"
                            1 => "M&#46; Ger&#243;nimo"
                            2 => "M&#46;D&#46; Crespo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Enferm Infecc Microbiol Clin"
                        "fecha" => "2009"
                        "volumen" => "27"
                        "paginaInicial" => "120"
                        "paginaFinal" => "121"
                        "itemHostRev" => array:3 [
                          "pii" => "S0140673612613439"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Subcutaneous injection of inhaled anesthetics produces cutaneous analgesia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46;C&#46; Chu"
                            1 => "S&#46;Z&#46; Wu"
                            2 => "W&#46;L&#46; Su"
                            3 => "J&#46;P&#46; Shieh"
                            4 => "C&#46;H&#46; Kao"
                            5 => "S&#46;T&#46; Ho"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/BF03017206"
                      "Revista" => array:6 [
                        "tituloSerie" => "Can J Anaesth"
                        "fecha" => "2008"
                        "volumen" => "55"
                        "paginaInicial" => "290"
                        "paginaFinal" => "294"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18451117"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010500000002/v1_201403090058/S1578219014000316/v1_201403090058/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6157"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case and Research Letters"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010500000002/v1_201403090058/S1578219014000316/v1_201403090058/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219014000316?idApp=UINPBA000044"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Case and Research Letter
Sevoflurane: A Valid Alternative for the Treatment of Vascular Ulcers?
Sevoflurano, ¿una alternativa en el tratamiento de las úlceras vasculares?
R.F. Lafuente-Urreza,
Corresponding author
, Y. Gilaberteb
a Servicio de Dermatología, Hospital Reina Sofía, Tudela, Spain
b Servicio de Dermatología, Hospital San Jorge, Huesca, Spain
Read
7078
Times
was read the article
2444
Total PDF
4634
Total HTML
Share statistics
 array:24 [
  "pii" => "S1578219014000316"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2013.02.017"
  "estado" => "S300"
  "fechaPublicacion" => "2014-03-01"
  "aid" => "824"
  "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
  "copyrightAnyo" => "2012"
  "documento" => "simple-article"
  "crossmark" => 0
  "subdocumento" => "cor"
  "cita" => "Actas Dermosifiliogr. 2014;105:202-3"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 2112
    "formatos" => array:3 [
      "EPUB" => 45
      "HTML" => 1429
      "PDF" => 638
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0001731013001075"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2013.02.010"
      "estado" => "S300"
      "fechaPublicacion" => "2014-03-01"
      "aid" => "824"
      "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; y AEDV"
      "documento" => "simple-article"
      "crossmark" => 0
      "subdocumento" => "cor"
      "cita" => "Actas Dermosifiliogr. 2014;105:202-3"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 5291
        "formatos" => array:3 [
          "EPUB" => 3
          "HTML" => 2911
          "PDF" => 2377
        ]
      ]
      "es" => array:10 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta cient&#237;fico-cl&#237;nica</span>"
        "titulo" => "Sevoflurano&#44; &#191;una alternativa en el tratamiento de las &#250;lceras vasculares&#63;"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "202"
            "paginaFinal" => "203"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Sevoflurane&#58; A Valid Alternative for the Treatment of Vascular Ulcers&#63;"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "R&#46;F&#46; Lafuente-Urrez, Y&#46; Gilaberte"
            "autores" => array:2 [
              0 => array:2 [
                "nombre" => "R&#46;F&#46;"
                "apellidos" => "Lafuente-Urrez"
              ]
              1 => array:2 [
                "nombre" => "Y&#46;"
                "apellidos" => "Gilaberte"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219014000316"
          "doi" => "10.1016/j.adengl.2013.02.017"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219014000316?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731013001075?idApp=UINPBA000044"
      "url" => "/00017310/0000010500000002/v1_201403120205/S0001731013001075/v1_201403120205/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1578219014000274"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2013.02.015"
    "estado" => "S300"
    "fechaPublicacion" => "2014-03-01"
    "aid" => "808"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2014;105:204-6"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2965
      "formatos" => array:3 [
        "EPUB" => 42
        "HTML" => 2515
        "PDF" => 408
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
      "titulo" => "Disseminated Sporotrichosis With Cutaneous and Testicular Involvement"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "204"
          "paginaFinal" => "206"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Esporotricosis diseminada con afecci&#243;n cut&#225;nea y testicular"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 857
              "Ancho" => 1500
              "Tamanyo" => 189235
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A&#44; PAS-stained smear showing cigar-shaped yeast cells &#40;original magnification &#215;100&#41;&#46; B&#44; Microscopic analysis of the culture showing sympodial conidia &#40;lactophenol blue&#44; original magnification &#215;40&#41;&#46; C&#44; Culture of <span class="elsevierStyleItalic">Sporothrix</span> species&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "C&#46;J&#46; Espinoza-Hern&#225;ndez, A&#46; Jes&#250;s-Silva, S&#46; Toussaint-Caire, R&#46; Arenas"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "C&#46;J&#46;"
              "apellidos" => "Espinoza-Hern&#225;ndez"
            ]
            1 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Jes&#250;s-Silva"
            ]
            2 => array:2 [
              "nombre" => "S&#46;"
              "apellidos" => "Toussaint-Caire"
            ]
            3 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Arenas"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731013000616"
        "doi" => "10.1016/j.ad.2013.02.002"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731013000616?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219014000274?idApp=UINPBA000044"
    "url" => "/15782190/0000010500000002/v1_201403090058/S1578219014000274/v1_201403090058/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1578219014000328"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2013.03.013"
    "estado" => "S300"
    "fechaPublicacion" => "2014-03-01"
    "aid" => "849"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2014;105:200-2"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1705
      "formatos" => array:3 [
        "EPUB" => 47
        "HTML" => 1319
        "PDF" => 339
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
      "titulo" => "Restoration of Response to Ustekinumab With Narrowband UV-B Phototherapy"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "200"
          "paginaFinal" => "202"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Recuperaci&#243;n de la respuesta a ustekinumab mediante fototerapia con ultravioleta B de banda estrecha"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 727
              "Ancho" => 1001
              "Tamanyo" => 132845
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A&#44; Patient 1&#46; Recurrence of psoriasis 30 weeks after initiation of ustekinumab &#40;PASI&#44; 9&#46;8&#41;&#46; B&#44; Patient 1&#46; PASI 75 after combining 17 sessions of narrowband UV-B therapy &#40;12&#46;9<span class="elsevierStyleHsp" style=""></span>J&#47;cm<span class="elsevierStyleSup">2</span>&#41; with ustekinumab &#40;PASI&#44; 2&#46;1&#41;&#46; PASI indicates Psoriasis Area and Severity Index&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "P&#46; Soro Mart&#237;nez, I&#46; Belinch&#243;n Romero, M&#46;P&#46; Arribas Granados"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Soro Mart&#237;nez"
            ]
            1 => array:2 [
              "nombre" => "I&#46;"
              "apellidos" => "Belinch&#243;n Romero"
            ]
            2 => array:2 [
              "nombre" => "M&#46;P&#46;"
              "apellidos" => "Arribas Granados"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S000173101300207X"
        "doi" => "10.1016/j.ad.2013.03.007"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S000173101300207X?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219014000328?idApp=UINPBA000044"
    "url" => "/15782190/0000010500000002/v1_201403090058/S1578219014000328/v1_201403090058/en/main.assets"
  ]
  "en" => array:13 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
    "titulo" => "Sevoflurane&#58; A Valid Alternative for the Treatment of Vascular Ulcers&#63;"
    "tieneTextoCompleto" => true
    "saludo" => "<span class="elsevierStyleItalic">To the Editor&#58;</span>"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "202"
        "paginaFinal" => "203"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "R&#46;F&#46; Lafuente-Urrez, Y&#46; Gilaberte"
        "autores" => array:2 [
          0 => array:4 [
            "nombre" => "R&#46;F&#46;"
            "apellidos" => "Lafuente-Urrez"
            "email" => array:2 [
              0 => "fati1997&#64;gmail&#46;com"
              1 => "rfz97&#64;yahoo&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Y&#46;"
            "apellidos" => "Gilaberte"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital Reina Sof&#237;a&#44; Tudela&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital San Jorge&#44; Huesca&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Sevoflurano&#44; &#191;una alternativa en el tratamiento de las &#250;lceras vasculares&#63;"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Vascular ulcers are a major health problem because of their frequency&#44; chronic nature&#44; and high recurrence rate&#46; The standard treatment&#44; which consists of cleansing&#44; debridement&#44; and application of dressings&#44; achieves cure rates of 65&#37; to 85&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The approaches used to accelerate scarring of these ulcers include dressings &#40;biologic&#44; synthetic&#44; or biosynthetic&#41;&#44; human amniotic membrane transplantation&#44;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> and autologous platelet-rich plasma&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Options for analgesia to control the pain associated with vascular ulcers include topical anesthetics such as the creams Emla &#40;lidocaine and prilocaine&#41; and Lambdalina &#40;lidocaine&#41;&#44; oral analgesics&#44; and even opiates&#46; These products aid in the healing process and in pain control&#44; although they can produce undesirable effects&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Sevoflurane is an inhaled general anesthetic from the halogenated ether family that is indicated for induction and maintenance of general anesthesia during hospital or outpatient surgery&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Its analgesic effect is both central<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> and peripheral&#44;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5-7</span></a> although it has traditionally been thought that halogenated anesthetics lack a peripheral analgesic effect&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Topical sevoflurane has been reported to be effective in the treatment of long-standing venous ulcers<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> and ischemic ulcers<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> that are refractory to standard treatment&#59; when irrigated topically over the painful ulcer bed&#44; it produces a rapid&#44; intense&#44; and lasting analgesic effect&#44; with a suitable safety profile that is well accepted by patients&#46; In addition&#44; it significantly reduces the size of the ulcer and the time necessary for epithelialization&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5-7</span></a> Its effect can be so intense that it is even possible to perform surgical debridement without the need for further analgesia&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Similarly&#44; it has been suggested that direct application of sevoflurane has an antimicrobial effect on ulcers that are superinfected by multiresistant <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span>&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> and a bactericidal effect has been reported in vitro against <span class="elsevierStyleItalic">Staphylococcus aureus</span>&#44; <span class="elsevierStyleItalic">P&#46; aeruginosa</span>&#44; and <span class="elsevierStyleItalic">Escherichia coli</span>&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Sevoflurane &#40;Sevorane&#41; is marketed as a colorless volatile liquid with no additives or preservatives in a 250-mL amber-colored polyethylene naphthalate bottle with a safety cap and a filling adapter&#46; Each milliliter of liquid contains 1<span class="elsevierStyleHsp" style=""></span>mL of sevoflurane &#40;INN&#41;&#46; It should be kept at room temperature and protected from sunlight&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Once the ulcer has been cleansed with saline solution&#44; sevoflurane is applied directly on the ulcer bed&#44; ensuring that the liquid is distributed throughout the tissue and taking care that it does not come into contact with the surrounding healthy skin&#46; It is necessary to wait 2<span class="elsevierStyleHsp" style=""></span>minutes before applying standard wound care<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;7</span></a> and placing the dressing&#46; A compression bandage should also be applied when necessary&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">To date&#44; 12 patients have been treated with topical sevoflurane&#44; and 2 of these cases have been published&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a> The case of an immunodepressed patient with a postsurgical wound superinfected by multiresistant <span class="elsevierStyleItalic">P&#46; aeruginosa</span> who was cured after several applications of sevoflurane is pending publication&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> At the 17<span class="elsevierStyleSup">th</span> Annual Meeting of the European Society of Regional Anesthesia in Barcelona in October 2011&#44; a series of 9 patients was presented &#40;6 women and 3 men with diabetes&#41;&#46; The patients had painful venous ulcers on the lower limbs that were refractory to regular analgesics and were treated with sevoflurane on an outpatient basis to control the pain&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> In all cases&#44; the reduction in pain at rest was rapid &#40;less than 2 minutes&#41;&#44; intense &#40;7&#46;4<span class="elsevierStyleHsp" style=""></span>&#91;0&#46;5&#93; to 2&#46;1<span class="elsevierStyleHsp" style=""></span>&#91;0&#46;6&#93; points with the first application and 7&#46;2<span class="elsevierStyleHsp" style=""></span>&#91;1&#46;3&#93; to 1&#46;1<span class="elsevierStyleHsp" style=""></span>&#91;0&#46;6&#93; points with all of the remaining 67 applications&#41;&#44; and lasting &#40;from 7 to 16<span class="elsevierStyleHsp" style=""></span>hours&#41;&#46; The ulcers were cured in 4 cases&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">The risk-benefit ratio of sevoflurane has proven very favorable to date&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;7</span></a> The only undesirable effects of topical application are pruritus at the borders of the wound and irritation of the surrounding skin with repeated applications&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Sevoflurane has not been reported to have sensitizing potential&#46; Similarly&#44; local irrigation with sevoflurane was well tolerated in patients with heart disease&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5-7</span></a> Systemic absorption of sevoflurane applied to an ulcer involving circulatory compromise is thought to be slow and incomplete&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> although blood levels have not been measured in patients treated with this procedure&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The mechanism underlying the analgesic&#44; epithelializing&#44; and antimicrobial effects of sevoflurane remains unknown&#46; Inhaled sevoflurane has no peripheral analgesic effect<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a>&#59; however&#44; topical or subcutaneous administration does produce a peripheral effect&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> When a halogenated agent is inhaled&#44; the partial pressure reached in the peripheral nociceptors may not be sufficient to block transmission of a painful stimulus&#59; however&#44; with direct application&#44; the nociceptors are exposed to sufficient partial pressure to block transmission of painful stimuli&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">In conclusion&#44; topical sevoflurane could prove to be a promising strategy for analgesia and epithelialization in the treatment of vascular ulcers&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Lafuente-Urrez RF&#44; Gilaberte Y&#46; Sevoflurano&#44; &#191;una alternativa en el tratamiento de las &#250;lceras vasculares&#63;&#46; Actas Dermosifiliogr&#46; 2014&#59;105&#58;202&#8211;203&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:10 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Aplicaci&#243;n de membrana amni&#243;tica en el tratamiento de las &#250;lceras cr&#243;nicas de extremidades inferiores"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46; Alsina-Gibert"
                            1 => "S&#46; Pedregosa-Fauste"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ad.2012.01.010"
                      "Revista" => array:7 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2012"
                        "volumen" => "103"
                        "paginaInicial" => "608"
                        "paginaFinal" => "613"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22578292"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0140673612613439"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tratamiento de &#250;lceras cut&#225;neas cr&#243;nicas con plasma aut&#243;logo rico en plaquetas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "I&#46; Bur&#243;n"
                            1 => "A&#46; Fern&#225;ndez-Tresguerres"
                            2 => "M&#46; Calvo"
                            3 => "F&#46; Alfageme"
                            4 => "C&#46; Villega"
                            5 => "R&#46; Fern&#225;ndez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Piel"
                        "fecha" => "2012"
                        "volumen" => "27"
                        "paginaInicial" => "429"
                        "paginaFinal" => "434"
                        "itemHostRev" => array:3 [
                          "pii" => "S0140673605675733"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Abbott&#44; FT-4456&#46; 2006&#46; Ficha t&#233;cnica del producto &#40;Sevorane&#174;&#41;&#46;"
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of propofol and sevoflurane on the excitability of rat spinal motoneurones and nociceptive reflexes in vitro"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "E&#46; Matute"
                            1 => "I&#46; Rivera-Arconada"
                            2 => "J&#46;A&#46; L&#243;pez-Garc&#237;a"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/bja/aeh217"
                      "Revista" => array:7 [
                        "tituloSerie" => "Br J Anaesth"
                        "fecha" => "2004"
                        "volumen" => "93"
                        "paginaInicial" => "422"
                        "paginaFinal" => "427"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15277303"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0140673602119118"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Analgesic effect of topical sevoflurane on venous ulcer intractable pain"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Ger&#243;nimo-Pardo"
                            1 => "A&#46; Mart&#237;nez-Monsalve"
                            2 => "M&#46; Mart&#237;nez-Serrano"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Phlebologie"
                        "fecha" => "2011"
                        "volumen" => "40"
                        "paginaInicial" => "95"
                        "paginaFinal" => "97"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sevoflurano como anest&#233;sico local en herida isqu&#233;mica de paciente cardi&#243;pata con insuficiencia respiratoria secundaria a morfina"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; Martinez Monsalve"
                            1 => "M&#46; Ger&#243;nimo Pardo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Heridas y cicatrizaci&#243;n"
                        "fecha" => "2011"
                        "volumen" => "6"
                        "paginaInicial" => "46"
                        "paginaFinal" => "49"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Usos alternativos del sevoflurano&#46; Efecto analg&#233;sico t&#243;pico"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Ger&#243;nimo Pardo"
                            1 => "M&#46; Martinez Serrano"
                            2 => "A&#46; Mart&#237;nez Molsalve"
                            3 => "J&#46;L&#46; Rueda Mart&#237;nez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Rev Electron Anestesia R"
                        "fecha" => "2012"
                        "volumen" => "4"
                        "paginaInicial" => "181"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Potency &#40;minimum alveolar anesthetic concentration&#41; of isoflurane is independent of peripheral anesthetic effects"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;F&#46; Antognini"
                            1 => "N&#46;D&#46; Kien"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Anesth Analg"
                        "fecha" => "1995"
                        "volumen" => "81"
                        "paginaInicial" => "69"
                        "paginaFinal" => "72"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7598285"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0140673612613439"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Actividad bactericida del sevoflurano frente a <span class="elsevierStyleItalic">Stafilococcus aureus&#44; Pseudomonas aeruginosa</span> y <span class="elsevierStyleItalic">Escherichia coli</span>"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Mart&#237;nez"
                            1 => "M&#46; Ger&#243;nimo"
                            2 => "M&#46;D&#46; Crespo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Enferm Infecc Microbiol Clin"
                        "fecha" => "2009"
                        "volumen" => "27"
                        "paginaInicial" => "120"
                        "paginaFinal" => "121"
                        "itemHostRev" => array:3 [
                          "pii" => "S0140673612613439"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Subcutaneous injection of inhaled anesthetics produces cutaneous analgesia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46;C&#46; Chu"
                            1 => "S&#46;Z&#46; Wu"
                            2 => "W&#46;L&#46; Su"
                            3 => "J&#46;P&#46; Shieh"
                            4 => "C&#46;H&#46; Kao"
                            5 => "S&#46;T&#46; Ho"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/BF03017206"
                      "Revista" => array:6 [
                        "tituloSerie" => "Can J Anaesth"
                        "fecha" => "2008"
                        "volumen" => "55"
                        "paginaInicial" => "290"
                        "paginaFinal" => "294"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18451117"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010500000002/v1_201403090058/S1578219014000316/v1_201403090058/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6157"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case and Research Letters"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010500000002/v1_201403090058/S1578219014000316/v1_201403090058/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219014000316?idApp=UINPBA000044"
]
Article information
ISSN: 15782190
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 8 9 17
2024 October 72 49 121
2024 September 66 27 93
2024 August 89 63 152
2024 July 84 31 115
2024 June 77 35 112
2024 May 77 51 128
2024 April 77 24 101
2024 March 68 20 88
2024 February 64 27 91
2024 January 58 34 92
2023 December 60 14 74
2023 November 78 34 112
2023 October 79 21 100
2023 September 84 27 111
2023 August 53 18 71
2023 July 50 32 82
2023 June 52 23 75
2023 May 54 27 81
2023 April 52 26 78
2023 March 54 21 75
2023 February 47 24 71
2023 January 52 32 84
2022 December 53 69 122
2022 November 28 32 60
2022 October 38 29 67
2022 September 45 42 87
2022 August 88 34 122
2022 July 35 45 80
2022 June 33 38 71
2022 May 72 39 111
2022 April 63 36 99
2022 March 53 46 99
2022 February 40 35 75
2022 January 72 34 106
2021 December 37 39 76
2021 November 46 42 88
2021 October 49 66 115
2021 September 41 44 85
2021 August 38 40 78
2021 July 35 32 67
2021 June 39 36 75
2021 May 33 34 67
2021 April 93 42 135
2021 March 95 30 125
2021 February 81 31 112
2021 January 56 27 83
2020 December 65 11 76
2020 November 35 20 55
2020 October 49 16 65
2020 September 50 18 68
2020 August 44 19 63
2020 July 38 18 56
2020 June 60 42 102
2020 May 52 18 70
2020 April 40 17 57
2020 March 50 16 66
2020 February 10 0 10
2019 December 8 8 16
2019 November 4 7 11
2019 October 0 7 7
2019 September 4 13 17
2019 August 4 11 15
2019 July 8 11 19
2019 June 2 17 19
2019 May 6 27 33
2019 April 2 17 19
2019 March 0 10 10
2019 February 4 9 13
2019 January 0 1 1
2018 December 1 3 4
2018 November 3 8 11
2018 October 2 0 2
2018 March 0 1 1
2018 February 36 7 43
2018 January 35 6 41
2017 December 40 7 47
2017 November 26 10 36
2017 October 38 10 48
2017 September 35 26 61
2017 August 28 14 42
2017 July 21 12 33
2017 June 47 17 64
2017 May 30 20 50
2017 April 26 28 54
2017 March 27 28 55
2017 February 20 13 33
2017 January 22 15 37
2016 December 31 16 47
2016 November 53 16 69
2016 October 59 21 80
2016 September 49 18 67
2016 August 50 10 60
2016 July 48 12 60
2016 June 16 8 24
2016 May 8 11 19
2016 April 2 14 16
2016 March 3 1 4
2016 February 14 1 15
2016 January 11 3 14
2015 December 12 1 13
2015 November 7 4 11
2015 October 11 12 23
2015 September 8 7 15
2015 August 10 4 14
2015 July 30 7 37
2015 June 33 12 45
2015 May 51 18 69
2015 April 28 7 35
2015 March 33 4 37
2015 February 28 4 32
2015 January 40 4 44
2014 December 30 6 36
2014 November 20 4 24
2014 October 41 4 45
2014 September 31 2 33
2014 August 20 6 26
2014 July 20 4 24
2014 June 26 6 32
2014 May 37 12 49
2014 April 76 8 84
2014 March 8 8 16
Show all

Follow this link to access the full text of the article

Idiomas
Actas Dermo-Sifiliográficas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?