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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Sporotrichosis is a subcutaneous mycosis caused by the dimorphic fungus <span class="elsevierStyleItalic">Sporothrix schenckii</span>&#44; which can have a subacute or chronic course&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> This disease has a worldwide distribution<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> and is an emerging infection in Europe&#44; where it has become quite common&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The most frequent method of transmission is traumatic inoculation&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> This polymorphic mycosis has 4 clinical forms&#58; lymphocutaneous&#44; fixed cutaneous&#44; disseminated&#44; and extracutaneous&#46; The extracutaneous and disseminated forms account for 4&#37; of total cases<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> and most often affect immunocompromised patients&#44; in whom the fungus acts as an opportunistic agent&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Amphotericin B is the treatment of choice for systemic disseminated forms&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We report the case of a 54 year-old male construction worker with no relevant medical history except chronic alcohol consumption&#46; The patient reported weight loss and intermittent fever associated with rapidly spreading dermatitis&#44; which had developed 6 months earlier and was characterized by multiple&#44; very painful necrotic pustules and ulcers of varying size with purulent exudate&#44; some with a verrucous surface&#46; The lesions affected a significant percentage of the body surface&#44; exposing muscles and tendons &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a> A-D&#41;&#46; The patient reported that he had undergone a right radical orchiectomy in another hospital for a testicular tumor that was likely malignant&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Direct examination of the skin lesions with potassium hydroxide and staining of smears with Gram stain and periodic acid Schiff &#40;PAS&#41; revealed abundant&#44; elongated&#44; cigar-shaped yeast cells &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>A&#41;&#46; Microscopic analysis of cells cultured in Sabouraud dextrose agar showed conidia arranged laterally on the hyphae &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a> B&#41;&#44; and identified the cells as <span class="elsevierStyleItalic">S schenckii</span> &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>C&#41;&#46; The following bacterial aggregates were also observed&#58; <span class="elsevierStyleItalic">Acinetobacter baumanni</span> &#40;&#62;<span class="elsevierStyleHsp" style=""></span>250&#44;000 colony-forming units&#41; in a qualitative skin biopsy culture&#59; multiresistant <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> in pustule exudate&#59; and oxacillin-resistant <span class="elsevierStyleItalic">Staphylococcus haemolyticus</span> in a blood culture&#46; The sporotrichin skin test was negative&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">The skin biopsy showed nodular and diffuse inflammatory infiltrate&#44; which was composed of lymphocytes&#44; epithelioid histiocytes&#44; multinucleated giant cells&#44; and neutrophils&#44; and produced suppurative granulomas and tissue necrosis &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Figs&#46; 3</a>A and B&#41;&#46; PAS and Grocott Gomori staining revealed abundant yeast cells&#44; both round and elongated &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Figs&#46; 3</a><span class="elsevierStyleHsp" style=""></span>C and D&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Histology of the tissue excised in the orchiectomy revealed similar findings&#59; chronic granulomatous inflammation was observed with multinucleated giant cells&#44; necrosis&#44; and polymorphonuclear infiltration &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Figs&#46; 4</a> A and B&#41;&#46; Staining showed spherical and cigar-shaped spores consistent with sporotrichosis &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Figs&#46; 4</a><span class="elsevierStyleHsp" style=""></span>C and D&#41;&#46;</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">Tumor staging ruled out fungal invasion of other organs&#44; and HIV serology was negative&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The patient&#8217; wounds were dressed and he was treated with amphotericin B deoxycholate for 14 days &#40;total cumulative dose of 1&#46;68<span class="elsevierStyleHsp" style=""></span>g&#41; in addition to antibiotics&#46; The clinical course of infection was prolonged due to several complications related to treatment&#44; associated infections&#44; and the disease itself&#46; These included septic shock&#44; nephrotoxicity &#40;acute renal failure&#44; hypokalemia&#44; hypomagnesemia&#44; metabolic acidosis&#41;&#44; liver failure&#44; and disseminated intravascular coagulation&#46; The patient died due to severe hemodynamic compromise&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Sporotrichosis is caused by the dimorphic fungus <span class="elsevierStyleItalic">S schenckii</span>&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The most common presentation is lymphocutaneous&#59; extracutaneous forms are rare&#44; and are more prevalent in immunosuppressed patients&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">The case described here was classified as systemic disseminated sporotrichosis with additional extracutaneous involvement&#44; with disseminated skin lesions&#44; general malaise and internal organ involvement&#46; This form is most common in immunocompromised patients&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">The fungal infection was highly invasive&#44; not only in terms of its cutaneous extension and testicular involvement&#44; but also the degree of necrosis&#44; depth of invasion&#44; and the destruction of adjacent muscles and tendons&#46; The sporotrichin skin test was anergic&#44; indicating a poor immune response to fungal invasion by the patient&#46; The only immunosuppression-associated factor detected was chronic alcoholism&#46; The patient had also recently undergone orchiectomy at another institution due to clinical suspicion of a malignant testicular tumor&#44; without prior confirmation of the nature of the lesion&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">It was not possible to determine the mechanism of infection&#44; but given the patient&#8217; profession he may have acquired the microorganism via cutaneous inoculation&#44; as the lesions first appeared on the left hand&#44; and later spread throughout the body by hematogenous dissemination&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Sporotrichosis is definitively diagnosed by culture of the fungus obtained from a skin biopsy&#46; Histology is usually not diagnostic&#44; as the yeast is present in small amounts&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> However&#44; in this patient&#44; a large number of fungal elements were detected in the cutaneous and testicular biopsies&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">The treatment of choice for extracutaneous and disseminated forms of sporotrichosis is amphotericin B&#44; followed by long-term itraconazole administration in immunocompromised patients&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">In summary&#44; 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        "texto" => "<p id="par0075" class="elsevierStylePara elsevierViewall">We thank Dr&#46; Jos&#233; G&#46; Chanona Vilchis&#44; Head of the Department of Surgical Pathology of the Instituto Nacional de Cancerolog&#237;a&#44; for providing testicular biopsy samples and histological descriptions&#46;</p> <p id="par0080" class="elsevierStylePara elsevierViewall">We also thank Dr&#46; Diana Vilar Compte of the Infectious Diseases Service at the Hospital General Dr&#46; Manuel Gea Gonz&#225;lez for microbiological identification of superadded bacterial infections&#44; and Dr&#46; Horacio Vidrio Morgado&#44; Surgical Oncology Resident at the Instituto Nacional de Cancerolog&#237;a&#44; and Dr&#46; Alberto de los R&#237;os&#44; Internal Medicine Resident at the Hospital General Dr&#46; Manuel Gea Gonz&#225;lez&#44; for their role in the metabolic and surgical management of the patient&#46;</p>"
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Case and Research Letter
Disseminated Sporotrichosis With Cutaneous and Testicular Involvement
Esporotricosis diseminada con afección cutánea y testicular
C.J. Espinoza-Hernández, A. Jesús-Silva, S. Toussaint-Caire, R. Arenas
Corresponding author
rarenas98@hotmail.com

Corresponding Author.
Servicio de Dermatología, Hospital General Dr. Manuel Gea González, México D.F., Mexico
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Sporotrichosis is a subcutaneous mycosis caused by the dimorphic fungus <span class="elsevierStyleItalic">Sporothrix schenckii</span>&#44; which can have a subacute or chronic course&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> This disease has a worldwide distribution<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> and is an emerging infection in Europe&#44; where it has become quite common&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The most frequent method of transmission is traumatic inoculation&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> This polymorphic mycosis has 4 clinical forms&#58; lymphocutaneous&#44; fixed cutaneous&#44; disseminated&#44; and extracutaneous&#46; The extracutaneous and disseminated forms account for 4&#37; of total cases<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> and most often affect immunocompromised patients&#44; in whom the fungus acts as an opportunistic agent&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Amphotericin B is the treatment of choice for systemic disseminated forms&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We report the case of a 54 year-old male construction worker with no relevant medical history except chronic alcohol consumption&#46; The patient reported weight loss and intermittent fever associated with rapidly spreading dermatitis&#44; which had developed 6 months earlier and was characterized by multiple&#44; very painful necrotic pustules and ulcers of varying size with purulent exudate&#44; some with a verrucous surface&#46; The lesions affected a significant percentage of the body surface&#44; exposing muscles and tendons &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a> A-D&#41;&#46; The patient reported that he had undergone a right radical orchiectomy in another hospital for a testicular tumor that was likely malignant&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Direct examination of the skin lesions with potassium hydroxide and staining of smears with Gram stain and periodic acid Schiff &#40;PAS&#41; revealed abundant&#44; elongated&#44; cigar-shaped yeast cells &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>A&#41;&#46; Microscopic analysis of cells cultured in Sabouraud dextrose agar showed conidia arranged laterally on the hyphae &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a> B&#41;&#44; and identified the cells as <span class="elsevierStyleItalic">S schenckii</span> &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>C&#41;&#46; The following bacterial aggregates were also observed&#58; <span class="elsevierStyleItalic">Acinetobacter baumanni</span> &#40;&#62;<span class="elsevierStyleHsp" style=""></span>250&#44;000 colony-forming units&#41; in a qualitative skin biopsy culture&#59; multiresistant <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> in pustule exudate&#59; and oxacillin-resistant <span class="elsevierStyleItalic">Staphylococcus haemolyticus</span> in a blood culture&#46; The sporotrichin skin test was negative&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">The skin biopsy showed nodular and diffuse inflammatory infiltrate&#44; which was composed of lymphocytes&#44; epithelioid histiocytes&#44; multinucleated giant cells&#44; and neutrophils&#44; and produced suppurative granulomas and tissue necrosis &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Figs&#46; 3</a>A and B&#41;&#46; PAS and Grocott Gomori staining revealed abundant yeast cells&#44; both round and elongated &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Figs&#46; 3</a><span class="elsevierStyleHsp" style=""></span>C and D&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Histology of the tissue excised in the orchiectomy revealed similar findings&#59; chronic granulomatous inflammation was observed with multinucleated giant cells&#44; necrosis&#44; and polymorphonuclear infiltration &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Figs&#46; 4</a> A and B&#41;&#46; Staining showed spherical and cigar-shaped spores consistent with sporotrichosis &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Figs&#46; 4</a><span class="elsevierStyleHsp" style=""></span>C and D&#41;&#46;</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">Tumor staging ruled out fungal invasion of other organs&#44; and HIV serology was negative&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The patient&#8217; wounds were dressed and he was treated with amphotericin B deoxycholate for 14 days &#40;total cumulative dose of 1&#46;68<span class="elsevierStyleHsp" style=""></span>g&#41; in addition to antibiotics&#46; The clinical course of infection was prolonged due to several complications related to treatment&#44; associated infections&#44; and the disease itself&#46; These included septic shock&#44; nephrotoxicity &#40;acute renal failure&#44; hypokalemia&#44; hypomagnesemia&#44; metabolic acidosis&#41;&#44; liver failure&#44; and disseminated intravascular coagulation&#46; The patient died due to severe hemodynamic compromise&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Sporotrichosis is caused by the dimorphic fungus <span class="elsevierStyleItalic">S schenckii</span>&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The most common presentation is lymphocutaneous&#59; extracutaneous forms are rare&#44; and are more prevalent in immunosuppressed patients&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">The case described here was classified as systemic disseminated sporotrichosis with additional extracutaneous involvement&#44; with disseminated skin lesions&#44; general malaise and internal organ involvement&#46; This form is most common in immunocompromised patients&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">The fungal infection was highly invasive&#44; not only in terms of its cutaneous extension and testicular involvement&#44; but also the degree of necrosis&#44; depth of invasion&#44; and the destruction of adjacent muscles and tendons&#46; The sporotrichin skin test was anergic&#44; indicating a poor immune response to fungal invasion by the patient&#46; The only immunosuppression-associated factor detected was chronic alcoholism&#46; The patient had also recently undergone orchiectomy at another institution due to clinical suspicion of a malignant testicular tumor&#44; without prior confirmation of the nature of the lesion&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">It was not possible to determine the mechanism of infection&#44; but given the patient&#8217; profession he may have acquired the microorganism via cutaneous inoculation&#44; as the lesions first appeared on the left hand&#44; and later spread throughout the body by hematogenous dissemination&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Sporotrichosis is definitively diagnosed by culture of the fungus obtained from a skin biopsy&#46; Histology is usually not diagnostic&#44; as the yeast is present in small amounts&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> However&#44; in this patient&#44; a large number of fungal elements were detected in the cutaneous and testicular biopsies&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">The treatment of choice for extracutaneous and disseminated forms of sporotrichosis is amphotericin B&#44; followed by long-term itraconazole administration in immunocompromised patients&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">In summary&#44; our patient&#8217; chronic alcohol abuse led to a state of severe immunosuppression&#44; favoring the fulminant course of sporotrichosis with significant fungal invasion&#44; which&#44; together with a lack of prior clinical suspicion as well as complications associated with the treatment&#44; concurrent bacterial infections&#44; and the mycosis itself&#44; resulted in the patient&#39;s death&#46;</p></span>"
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        "titulo" => "Acknowledgements"
        "texto" => "<p id="par0075" class="elsevierStylePara elsevierViewall">We thank Dr&#46; Jos&#233; G&#46; Chanona Vilchis&#44; Head of the Department of Surgical Pathology of the Instituto Nacional de Cancerolog&#237;a&#44; for providing testicular biopsy samples and histological descriptions&#46;</p> <p id="par0080" class="elsevierStylePara elsevierViewall">We also thank Dr&#46; Diana Vilar Compte of the Infectious Diseases Service at the Hospital General Dr&#46; Manuel Gea Gonz&#225;lez for microbiological identification of superadded bacterial infections&#44; and Dr&#46; Horacio Vidrio Morgado&#44; Surgical Oncology Resident at the Instituto Nacional de Cancerolog&#237;a&#44; and Dr&#46; Alberto de los R&#237;os&#44; Internal Medicine Resident at the Hospital General Dr&#46; Manuel Gea Gonz&#225;lez&#44; for their role in the metabolic and surgical management of the patient&#46;</p>"
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Article information
ISSN: 15782190
Original language: English
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