array:24 [
  "pii" => "S1578219013002436"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2012.07.037"
  "estado" => "S300"
  "fechaPublicacion" => "2013-12-01"
  "aid" => "697"
  "copyright" => "Elsevier España, S.L. and AEDV"
  "copyrightAnyo" => "2012"
  "documento" => "simple-article"
  "crossmark" => 0
  "subdocumento" => "crp"
  "cita" => "Actas Dermosifiliogr. 2013;104:920-3"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 3919
    "formatos" => array:3 [
      "EPUB" => 51
      "HTML" => 2859
      "PDF" => 1009
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0001731012003535"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2012.07.007"
      "estado" => "S300"
      "fechaPublicacion" => "2013-12-01"
      "aid" => "697"
      "copyright" => "Elsevier España, S.L. and AEDV"
      "documento" => "article"
      "crossmark" => 0
      "subdocumento" => "sco"
      "cita" => "Actas Dermosifiliogr. 2013;104:920-3"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 4658
        "formatos" => array:3 [
          "EPUB" => 2
          "HTML" => 3481
          "PDF" => 1175
        ]
      ]
      "es" => array:13 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Caso cl&#237;nico</span>"
        "titulo" => "Reacci&#243;n granulomatosa a cuerpo extra&#241;o a s&#237;lice&#44; silicona y &#225;cido hialur&#243;nico&#44; en paciente con sarcoidosis inducida por interfer&#243;n"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "tieneResumen" => array:2 [
          0 => "es"
          1 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "920"
            "paginaFinal" => "923"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Foreign Body Granulomatous Reaction to Silica&#44; Silicone&#44; and Hyaluronic Acid in a Patient With Interferon-Induced Sarcoidosis"
          ]
        ]
        "contieneResumen" => array:2 [
          "es" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0015"
            "etiqueta" => "Figura 3"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr3.jpeg"
                "Alto" => 645
                "Ancho" => 1750
                "Tamanyo" => 325508
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A&#41; El estudio histopatol&#243;gico del ganglio axilar izquierdo mostraba granulomas sarcoideos de forma difusa &#40;HE&#215;200&#41;&#46; B&#41; En el centro de la adenopat&#237;a se observaban vacuolas claras en el espacio extracelular y en el citoplasma de c&#233;lulas gigantes multinucleadas&#44; mostrando un material refr&#225;ctil en su interior &#40;HE&#215;400&#41;&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "R&#46; Novoa, M&#46;A&#46; Barnadas, X&#46; Torras, R&#46; Curell, A&#46; Alomar"
            "autores" => array:5 [
              0 => array:2 [
                "nombre" => "R&#46;"
                "apellidos" => "Novoa"
              ]
              1 => array:2 [
                "nombre" => "M&#46;A&#46;"
                "apellidos" => "Barnadas"
              ]
              2 => array:2 [
                "nombre" => "X&#46;"
                "apellidos" => "Torras"
              ]
              3 => array:2 [
                "nombre" => "R&#46;"
                "apellidos" => "Curell"
              ]
              4 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Alomar"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219013002436"
          "doi" => "10.1016/j.adengl.2012.07.037"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013002436?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012003535?idApp=UINPBA000044"
      "url" => "/00017310/0000010400000010/v1_201311281152/S0001731012003535/v1_201311281152/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1578219013002448"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2013.01.005"
    "estado" => "S300"
    "fechaPublicacion" => "2013-12-01"
    "aid" => "797"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2013;104:924-5"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3111
      "formatos" => array:3 [
        "EPUB" => 44
        "HTML" => 2616
        "PDF" => 451
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
      "titulo" => "Ulcerated Giant Pilomatrixoma in a Child"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "924"
          "paginaFinal" => "925"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Pilomatrixoma gigante y ulcerado en un ni&#241;o"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 952
              "Ancho" => 951
              "Tamanyo" => 146298
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Nuclear magnetic resonance imaging&#58; exophytic formation with a heterogeneous nodule surrounded by a hypointense halo and abundant vascularity in the stalk&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "P&#46; Stefano, S&#46; Apa, B&#46; Balancini"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Stefano"
            ]
            1 => array:2 [
              "nombre" => "S&#46;"
              "apellidos" => "Apa"
            ]
            2 => array:2 [
              "nombre" => "B&#46;"
              "apellidos" => "Balancini"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731013000197"
        "doi" => "10.1016/j.ad.2013.01.001"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731013000197?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013002448?idApp=UINPBA000044"
    "url" => "/15782190/0000010400000010/v1_201311281142/S1578219013002448/v1_201311281142/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1578219013002424"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2012.09.024"
    "estado" => "S300"
    "fechaPublicacion" => "2013-12-01"
    "aid" => "738"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "crp"
    "cita" => "Actas Dermosifiliogr. 2013;104:915-9"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 5640
      "formatos" => array:3 [
        "EPUB" => 69
        "HTML" => 4406
        "PDF" => 1165
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case Report</span>"
      "titulo" => "Erythema Nodosum Leprosum and Reversal Reaction in 2 Cases of Imported Leprosy"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "915"
          "paginaFinal" => "919"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Eritema nudoso leproso y reacci&#243;n de reversi&#243;n en 2 casos de lepra importada"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0015"
          "etiqueta" => "Figure 3"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr3.jpeg"
              "Alto" => 669
              "Ancho" => 900
              "Tamanyo" => 257951
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Lymphocytic&#44; neutrophilic&#44; and histiocytic infiltrate in the deep dermis in a patient with erythema nodosum leprosum &#40;hematoxylin-eosin&#44; original magnification &#215;40&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "A&#46; Pulido-P&#233;rez, M&#46;D&#46; Mendoza-Cembranos, J&#46;A&#46; Avil&#233;s-Izquierdo, R&#46; Su&#225;rez-Fern&#225;ndez"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Pulido-P&#233;rez"
            ]
            1 => array:2 [
              "nombre" => "M&#46;D&#46;"
              "apellidos" => "Mendoza-Cembranos"
            ]
            2 => array:2 [
              "nombre" => "J&#46;A&#46;"
              "apellidos" => "Avil&#233;s-Izquierdo"
            ]
            3 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Su&#225;rez-Fern&#225;ndez"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731012004553"
        "doi" => "10.1016/j.ad.2012.09.009"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012004553?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013002424?idApp=UINPBA000044"
    "url" => "/15782190/0000010400000010/v1_201311281142/S1578219013002424/v1_201311281142/en/main.assets"
  ]
  "en" => array:20 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case Report</span>"
    "titulo" => "Foreign Body Granulomatous Reaction to Silica&#44; Silicone&#44; and Hyaluronic Acid in a Patient With Interferon-Induced Sarcoidosis"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "920"
        "paginaFinal" => "923"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "R&#46; Novoa, M&#46;A&#46; Barnadas, X&#46; Torras, R&#46; Curell, A&#46; Alomar"
        "autores" => array:5 [
          0 => array:3 [
            "nombre" => "R&#46;"
            "apellidos" => "Novoa"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          1 => array:4 [
            "nombre" => "M&#46;A&#46;"
            "apellidos" => "Barnadas"
            "email" => array:1 [
              0 => "MBarnadas&#64;santpau&#46;cat"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "X&#46;"
            "apellidos" => "Torras"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "R&#46;"
            "apellidos" => "Curell"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "A&#46;"
            "apellidos" => "Alomar"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital de la Santa Creu i Sant Pau&#44; Barcelona&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Digestivo&#44; Centro de Investigaci&#243;n Biom&#233;dica en Red de Enfermedades Hep&#225;ticas y Digestivas&#44; Hospital de la Santa Creu i Sant Pau&#44; Barcelona&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Servicio de Anatom&#237;a Patol&#243;gica&#44; Hospital de la Santa Creu i Sant Pau&#44; Barcelona&#44; Spain"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Reacci&#243;n granulomatosa a cuerpo extra&#241;o a s&#237;lice&#44; silicona y &#225;cido hialur&#243;nico&#44; en paciente con sarcoidosis inducida por interferon"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 645
            "Ancho" => 1750
            "Tamanyo" => 337580
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A&#44; Histopathology of the left axillary lymph node showing widespread sarcoid granulomas &#40;hematoxylin and eosin&#44; original magnification&#44; &#215;200&#41;&#46; B&#44; The center of the node contains clear vacuoles in the extracellular space and in the cytoplasm of multinucleated giant cells&#46; Note the refractile material within these vacuoles &#40;hematoxylin and eosin&#44; original magnification&#44; &#215;400&#41;&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Sarcoidosis is more prevalent in patients receiving interferon than in the general population&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> Furthermore&#44; the appearance of granulomas in the skin is known to be related to the presence of foreign bodies&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> We describe the case of a patient with chronic hepatitis C who developed sarcoidosis while receiving treatment with pegylated interferon alfa combined with ribavirin&#46; The sarcoid granulomas were located in the skin and were associated with 3 different foreign bodies&#58; silica&#44; hyaluronic acid&#44; and silicone within a lymph node&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Case Description</span><p id="par0010" class="elsevierStylePara elsevierViewall">The patient was a 54-year-old woman who was referred to the dermatology department in September 2009 with erythematous-violaceous nodules on her face&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Important findings in her past history included silicone gel implants to both breasts 19 years previously &#40;these implants had not been replaced&#41; and chronic infection by hepatitis C virus &#40;HCV&#41;&#44; genotype 1b&#44; which had been detected 11 years earlier&#44; giving rise to severe liver fibrosis&#46; In September 2008 she started treatment with subcutaneous interferon alfa 2a &#40;180<span class="elsevierStyleHsp" style=""></span>&#956;g weekly&#41; combined with oral ribavirin &#40;1000<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#41;&#44; which led to a partial early virologic response&#46; Erythropoietin &#40;40&#160;000<span class="elsevierStyleHsp" style=""></span>IU&#41; was added at week 4 owing to anemia secondary to antiviral treatment&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Physical examination revealed erythematous-violaceous nodules in the interciliary sulci and nasolabial folds &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#44; A and B&#41;&#46; The patient reported that she had had hyaluronic acid injections at these sites 1 year earlier&#46; She had received treatment with intralesional corticosteroids but had shown no signs of improvement&#46; In addition&#44; she presented nodules covered by skin of normal appearance on both sides of her forehead in areas where she denied having had injections of hyaluronic acid&#46; She also presented brownish papules in a linear distribution on her left shoulder &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#44; elbows&#44; knees&#44; and in the proximity of old scars&#44; and the axillary lymph nodes were palpable bilaterally&#46; The patient reported having had dry cough and fever &#40;38<span class="elsevierStyleHsp" style=""></span>&#176;C&#41; during the previous month&#46; Laboratory tests revealed the following important results&#58; hemoglobin&#44; 10&#46;1<span class="elsevierStyleHsp" style=""></span>g&#47;dL&#59; white cell count&#44; 2330&#160;&#956;L&#59; and angiotensin-converting enzyme&#44; 80<span class="elsevierStyleHsp" style=""></span>U&#47;L &#40;reference range&#44; 20-60&#160;U&#47;L&#41;&#46; The results of the other laboratory tests&#8212;including renal and liver function and blood and urinary calcium and phosphate&#8212;were within the normal range&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Computed tomography of the chest and abdomen revealed changes in the breast implants&#44; which had acquired a nodular morphology&#44; and bilateral axillary lymphadenopathies&#44; as well as a 1-cm nodule in segment IV of the liver&#44; together with 2 other hepatic lesions measuring &#60;1<span class="elsevierStyleHsp" style=""></span>cm that were suggestive of cysts&#46; Magnetic resonance of the breasts revealed an intracapsular rupture of the implant on the left side&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Biopsy of a papule on the left shoulder showed epithelioid granulomas with no central necrosis in the papillary and upper reticular dermis&#44; surrounded by sparse lymphocytes &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>A&#41;&#46; Shiny particles were observed in the cytoplasm of some histiocytes and of some multinucleated giant cells &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>B&#41;&#46; These particles were birefringent with polarized light and were interpreted to be silica&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">Histopathology of an axillary lymph node revealed numerous nonnecrotizing sarcoid epithelioid granulomas &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>A&#41;&#46; In addition&#44; clear extracellular vacuoles of different sizes were present in the center of the node and there were abundant multinucleated giant cells with cytoplasmic vacuoles&#46; Nonbirefringent refractile material was observed inside some vacuoles&#46; Given that the patient had silicone breast implants&#44; this finding was compatible with silicone from the implants &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>B&#41;&#44; thus indicating silicone lymphadenopathy&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">A diagnosis of sarcoidosis was made&#46; As no visceral involvement was observed&#44; the same antiviral treatment was maintained&#46; However&#44; in November 2009&#44; hepatic cholestasis was detected &#40;alkaline phosphatase 245<span class="elsevierStyleHsp" style=""></span>U&#47;L &#91;reference range&#44; 35-110&#160;U&#47;L&#93; and gamma-glutamyltransferase 469<span class="elsevierStyleHsp" style=""></span>U&#47;L &#91;reference value&#44;<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>43&#160;U&#47;L&#93;&#41; and treatment with pegylated interferon alfa 2a and ribavirin was stopped&#46; The results of the laboratory tests subsequently returned to normal values&#44; the size of the cutaneous lesions gradually decreased&#44; and the cough and fever resolved&#46; In addition&#44; the virologic response was maintained 1 year after completing 60 weeks of antiviral treatment&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0045" class="elsevierStylePara elsevierViewall">Sarcoidosis is a multisystem granulomatous disease of unknown etiology that is sometimes associated with interferon administered to treat other diseases&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#8211;7</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Sarcoidosis is detected more frequently in HCV-infected patients than in the general population&#46; In their 2010 study&#44; Faurie et al&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> found a prevalence of 0&#46;12&#37; in a series of HCV-infected patients&#59; in the general population&#44; prevalence has been estimated to be between 1 and 40 cases per 100&#160;000&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> In 2005&#44; Ramos-Casals et al&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> reviewed 68 cases of sarcoidosis associated with chronic HCV infection and compared their findings with a control group of non&#8211;HCV-infected patients&#46; Those authors found that skin involvement in sarcoidosis was more frequent in HCV-infected patients &#40;56&#37;&#41; than in non&#8211;HCV-infected patients &#40;22&#37;&#41;&#46; In 4 cases&#44; the granulomas were adjacent to old scars and tattoos&#46; Faurie et al&#46; considered that sarcoidosis had been triggered by antiviral treatment in most cases &#40;79&#46;4&#37;&#41;&#46; The potential role of interferon could arise from the induction of a type 1 helper T-cell response&#44; which is thought to affect the formation of granulomas in patients with sarcoidosis&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Both pegylated and nonpegylated interferon alfa&#44; whether in monotherapy or in combination with ribavirin&#44; have been cited as possible triggers of sarcoidosis&#46; Prognosis is generally good in these cases&#44; and sarcoidosis can resolve spontaneously in 85&#37; of cases if antiviral treatment is stopped&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> In the case we report&#44; antiviral treatment was maintained until the onset of systemic manifestations&#46; At that time&#44; antiviral therapy was discontinued&#44; even though the 72-week regimen had not been completed&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">In the present case&#44; we think that sarcoidosis was probably induced by interferon and ribavirin for 2 reasons&#58; first&#44; the lesions appeared 11 months after starting treatment&#44; and second&#44; the skin and liver lesions&#44; the liver function tests&#44; angiotensin-converting enzyme levels&#44; and changes in the breast implants returned to normal once interferon was discontinued&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">We believe that the case we report is unusual&#44; as the sites of the sarcoid granulomas were associated with the presence of 3 foreign bodies &#40;silica&#44; hyaluronic acid&#44; and silicone&#41;&#46; The simultaneous onset of cutaneous sarcoid granulomas associated with 2 foreign bodies &#40;silica and silicone&#41; has been described elsewhere&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> Of note&#44; Marcoval et al&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> demonstrated the presence of foreign bodies in cutaneous granulomatous lesions in 22&#37; of 65 patients with systemic sarcoidosis and skin involvement and suggested that these foreign bodies could induce the formation of granulomas in patients with sarcoidosis&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">There have been reports of systemic sarcoidosis associated with tattoos<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> and fillers &#40;permanent and reabsorbable&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">10&#8211;12</span></a> Two studies<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#44;12</span></a> have reported sarcoid granulomas associated with injection of hyaluronic acid in 2 women&#58; one of those patients had hepatitis C treated with interferon&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">We report the first case of sarcoid granulomas developing in a silicone-induced lymphadenopathy&#46; This complication of breast implants is caused by migration of silicone to the lymph nodes&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> Sarcoidosis has been reported in patients with breast implants&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">14&#44;15</span></a> The condition improved spontaneously in 1 case&#44;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> and in the other&#44; the patient&#39;s condition improved dramatically after removal of the implants&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">We believe that sarcoidosis associated with HCV infection is of special interest for the dermatologist&#44; since it frequently affects the skin &#40;56&#37; of cases&#41;&#46; In addition&#44; cosmetic procedures such as tattoos and the use of fillers may induce the appearance of sarcoid granulomas in patients who develop sarcoidosis&#46; It has been suggested that the informed consent signed before cosmetic microimplant procedures should include the risk of severe interaction between the injected material and interferon or other immunostimulants&#44; were the patient to need such treatments in the future&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> This warning should be given even before injection of reabsorbable material&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Any changes in the areas where cosmetic materials have been injected should alert the dermatologist and cosmetic surgeon to a possible diagnosis of sarcoidosis&#44; especially in patients with HCV infection&#46; Furthermore&#44; before receiving cosmetic injections&#44; patients should be warned of the risk of developing or reactivating sarcoidosis in the future&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Ethical Disclosures</span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Protection of human and animal subjects</span><p id="par0085" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this investigation&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Confidentiality of data</span><p id="par0090" class="elsevierStylePara elsevierViewall">The authors declare that they followed their hospital&#39;s regulations regarding the publication of patient information and that written informed consent for voluntary participation was obtained for all patients&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Right to privacy and informed consent</span><p id="par0095" class="elsevierStylePara elsevierViewall">The authors declare that no private patient data are disclosed in this article&#46;</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conflicts of Interest</span><p id="par0100" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:10 [
        0 => array:2 [
          "identificador" => "xres295315"
          "titulo" => "Abstract"
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec279236"
          "titulo" => "Keywords"
        ]
        2 => array:2 [
          "identificador" => "xres295314"
          "titulo" => "Resumen"
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec279235"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Case Description"
        ]
        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Discussion"
        ]
        7 => array:3 [
          "identificador" => "sec0020"
          "titulo" => "Ethical Disclosures"
          "secciones" => array:3 [
            0 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "Protection of human and animal subjects"
            ]
            1 => array:2 [
              "identificador" => "sec0030"
              "titulo" => "Confidentiality of data"
            ]
            2 => array:2 [
              "identificador" => "sec0035"
              "titulo" => "Right to privacy and informed consent"
            ]
          ]
        ]
        8 => array:2 [
          "identificador" => "sec0040"
          "titulo" => "Conflicts of Interest"
        ]
        9 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2012-03-05"
    "fechaAceptado" => "2012-07-20"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec279236"
          "palabras" => array:8 [
            0 => "Sarcoidosis"
            1 => "Hepatitis C"
            2 => "Foreign-body granulomas"
            3 => "Silica"
            4 => "Silicone"
            5 => "Hyaluronic acid"
            6 => "Interferon"
            7 => "Silicone lymphadenopathy"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec279235"
          "palabras" => array:8 [
            0 => "Sarcoidosis"
            1 => "Hepatitis C"
            2 => "Granulomas a cuerpo extra&#241;o"
            3 => "S&#237;lice"
            4 => "Silicona"
            5 => "&#193;cido hialur&#243;nico"
            6 => "Interfer&#243;n"
            7 => "Linfadenopat&#237;a por silicona"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">We report the case of a patient who developed sarcoid granulomas 11 months after starting treatment with pegylated interferon alfa and ribavirin for chronic hepatitis C&#46; The sites of the lesions were related to 3 different foreign bodies&#58; silica in old scars on the skin&#44; hyaluronic acid that had been injected into facial tissues&#44; and silicone in an axillary lymph node draining the area of a breast implant&#46; Systemic sarcoidosis was diagnosed on the basis of a history of dry cough and fever and blood tests that revealed elevated angiotensin converting enzyme and liver enzymes&#46; Interruption of the antiviral therapy led to normalization of liver function tests and disappearance of the skin lesions and lymphadenopathies&#46; Dermatologists and cosmetic surgeons should be aware of the risk of sarcoid lesions related to cosmetic implants in patients who may require treatment with interferon in the future&#46;</p>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se describe el caso de una paciente que desarroll&#243; granulomas sarcoideos 11 meses despu&#233;s de haber iniciado interfer&#243;n &#945; pegilado y ribavirina&#44; como tratamiento de la hepatitis cr&#243;nica C&#46; Las lesiones se localizaban en relaci&#243;n a 3 cuerpos extra&#241;os diferentes&#58; s&#237;lice en cicatrices cut&#225;neas antiguas&#44; &#225;cido hialur&#243;nico que se hab&#237;a inyectado previamente en la cara&#44; y silicona que se detect&#243; en una adenopat&#237;a axilar donde hab&#237;a drenado de un implante mamario previo&#46; La paciente tambi&#233;n aquejaba tos seca&#44; fiebre y en la anal&#237;tica se detect&#243; un incremento de la enzima convertidora de angiotensina y de las enzimas hep&#225;ticas&#46; A partir de estos hallazgos se diagnostic&#243; de sarcoidosis sist&#233;mica y se suspendi&#243; el tratamiento antiviral con posterior normalizaci&#243;n de las pruebas hep&#225;ticas&#44; desaparici&#243;n de las lesiones cut&#225;neas y de las adenopat&#237;as&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Los dermat&#243;logos y cosmet&#243;logos deben ser conscientes del riesgo de aparici&#243;n de manifestaciones sarcoideas en las &#225;reas donde se han realizado implantes est&#233;ticos&#44; en los sujetos que en un futuro requieran tratamiento con interfer&#243;n&#46;</p>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Novoa R&#44; Barnadas MA&#44; Torras X&#44; Curell R&#44; Alomar A&#46; Reacci&#243;n granulomatosa a cuerpo extra&#241;o a s&#237;lice&#44; silicona y &#225;cido hialur&#243;nico&#44; en paciente con sarcoidosis inducida por interferon&#46; Actas Dermosifiliogr&#46; 2013&#59;104&#58;920&#8211;923&#46;</p>"
      ]
    ]
    "multimedia" => array:3 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 653
            "Ancho" => 1000
            "Tamanyo" => 118369
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">A&#44; Clinical appearance of nodules in a nasolabial fold&#46; B&#44; Clinical appearance of linear papules on an old scar&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 648
            "Ancho" => 1750
            "Tamanyo" => 326248
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">A&#44; Histopathology of a papule from the shoulder&#46; Sarcoid granulomas are visible in the reticular dermis &#40;hematoxylin and eosin&#44; original magnification&#44; &#215;200&#41;&#46; B&#44; Detail of shiny particles in the cytoplasm of multinucleated giant cells &#40;hematoxylin and eosin&#44; original magnification&#44; &#215;400&#41;&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 645
            "Ancho" => 1750
            "Tamanyo" => 337580
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A&#44; Histopathology of the left axillary lymph node showing widespread sarcoid granulomas &#40;hematoxylin and eosin&#44; original magnification&#44; &#215;200&#41;&#46; B&#44; The center of the node contains clear vacuoles in the extracellular space and in the cytoplasm of multinucleated giant cells&#46; Note the refractile material within these vacuoles &#40;hematoxylin and eosin&#44; original magnification&#44; &#215;400&#41;&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:15 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sarcoidosis in patients with chronic hepatitis C virus infection&#58; analysis of 68 cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Ramos-Casals"
                            1 => "J&#46; Ma&#241;&#225;"
                            2 => "N&#46; Nardi"
                            3 => "P&#46; Brito-Zer&#243;n"
                            4 => "A&#46; Xaubet"
                            5 => "J&#46;M&#46; S&#225;nchez Tapias"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Medicine"
                        "fecha" => "2005"
                        "volumen" => "84"
                        "paginaInicial" => "69"
                        "paginaFinal" => "80"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15758836"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sarcoidosis and hepatitis C&#58; clinical description of 11 cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "P&#46; Faurie"
                            1 => "C&#46; Broussolle"
                            2 => "F&#46; Zoulim"
                            3 => "C&#46; Trepo"
                            4 => "P&#46; S&#232;ve"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/MEG.0b013e32833834bc"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Gastroenterol Hepatol"
                        "fecha" => "2010"
                        "volumen" => "22"
                        "paginaInicial" => "967"
                        "paginaFinal" => "972"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20216423"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Foreign bodies in granulomatous cutaneous lesions of patients with systemic sarcoidosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46; Marcoval"
                            1 => "J&#46; Ma&#241;&#225;"
                            2 => "A&#46; Moreno"
                            3 => "I&#46; Gallego"
                            4 => "Y&#46; Fortuno"
                            5 => "J&#46; Peyr&#237;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "2001"
                        "volumen" => "137"
                        "paginaInicial" => "427"
                        "paginaFinal" => "430"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11295921"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pulmonary sarcoidosis following interferon therapy for advanced renal cell carcinoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "E&#46;A&#46; Abdi"
                            1 => "G&#46;K&#46; Nguyen"
                            2 => "R&#46;N&#46; Ludwig"
                            3 => "W&#46;J&#46; Dickout"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer"
                        "fecha" => "1987"
                        "volumen" => "59"
                        "paginaInicial" => "896"
                        "paginaFinal" => "900"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3815268"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interferon alpha therapy associated with the development of sarcoidosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46; Pietrapaoli"
                            1 => "J&#46; Modrak"
                            2 => "M&#46; Utell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1999"
                        "volumen" => "116"
                        "paginaInicial" => "569"
                        "paginaFinal" => "572"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10453892"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interferon-induced cutaneous sarcoidosis in melanoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "C&#46; Su&#225;rez-Garc&#237;a"
                            1 => "A&#46; P&#233;rez-Gil"
                            2 => "S&#46; Pereira-Gallardo"
                            3 => "M&#46; Codes-Villena"
                            4 => "A&#46; Garc&#237;a-Escudero"
                            5 => "F&#46; Miguel Camacho"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/CMR.0b013e32832f51f2"
                      "Revista" => array:6 [
                        "tituloSerie" => "Melanoma Res"
                        "fecha" => "2009"
                        "volumen" => "19"
                        "paginaInicial" => "391"
                        "paginaFinal" => "394"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19770687"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sarcoidosis following beta-interferon therapy for multiple myeloma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "E&#46; Bobbio-Pallavicini"
                            1 => "C&#46; Valsecchi"
                            2 => "F&#46; Tacconi"
                            3 => "M&#46; Moroni"
                            4 => "C&#46; Porta"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Sarcoidosis"
                        "fecha" => "1995"
                        "volumen" => "12"
                        "paginaInicial" => "140"
                        "paginaFinal" => "142"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8532962"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Simultaneous presentation of silicone and silica granuloma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "L&#46; Pimentel"
                            1 => "M&#46; Barnadas"
                            2 => "D&#46; Vidal"
                            3 => "F&#46; Sancho"
                            4 => "R&#46; Fontarnau"
                            5 => "A&#46; Alomar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "63897"
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatology"
                        "fecha" => "2002"
                        "volumen" => "205"
                        "paginaInicial" => "162"
                        "paginaFinal" => "165"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12218233"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Development of sarcoidosis in cosmetic tattoos"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46;D&#46; Antonovich"
                            1 => "J&#46;P&#46; Callen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/archderm.141.7.869"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "2005"
                        "volumen" => "141"
                        "paginaInicial" => "869"
                        "paginaFinal" => "872"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16027303"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cosmetic permanent fillers for soft tissue augmentation&#46; A new contraindication for interferon therapies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46; Fischer"
                            1 => "G&#46; Metzler"
                            2 => "M&#46; Schaller"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/archderm.143.4.507"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "2007"
                        "volumen" => "143"
                        "paginaInicial" => "507"
                        "paginaFinal" => "510"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17438184"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Facial cosmetic filler injections as possible target for systemic sarcoidosis in patients treated with interferon for chronic hepatitis C&#58; two cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "V&#46; Descamps"
                            1 => "J&#46; Landry"
                            2 => "C&#46; Franc&#233;s"
                            3 => "E&#46; Marinho"
                            4 => "V&#46; Ratziu"
                            5 => "O&#46; Chosidow"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000128281"
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatology"
                        "fecha" => "2008"
                        "volumen" => "217"
                        "paginaInicial" => "81"
                        "paginaFinal" => "84"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18446029"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Scar sarcoidosis after hyaluronic acid injection"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46; Dal Sacco"
                            1 => "E&#46; Cozzani"
                            2 => "A&#46; Parodi"
                            3 => "A&#46; Rebora"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-4632.2005.01930.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Dermatol"
                        "fecha" => "2005"
                        "volumen" => "44"
                        "paginaInicial" => "411"
                        "paginaFinal" => "412"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15869540"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Silicone lymphadenopathy associated with augmentation mammaplasty&#46; Morphologic features of nine cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "L&#46;D&#46; Truong"
                            1 => "J&#46; Cartwright Jr&#46;"
                            2 => "M&#46;D&#46; Goodman"
                            3 => "D&#46; Woznicki"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Surg Pathol"
                        "fecha" => "1988"
                        "volumen" => "12"
                        "paginaInicial" => "484"
                        "paginaFinal" => "491"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3377110"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous and pulmonary sarcoidosis in a Hong Kong Chinese woman with silicone breast prostheses"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "K&#46;C&#46; Chang"
                            1 => "K&#46;T&#46; Chan"
                            2 => "L&#46;Y&#46; Chong"
                            3 => "K&#46;S&#46; Lau"
                            4 => "C&#46;M&#46; Tam"
                            5 => "C&#46;W&#46; Lam"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Respirology"
                        "fecha" => "2003"
                        "volumen" => "8"
                        "paginaInicial" => "379"
                        "paginaFinal" => "382"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14528880"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Remission of sarcoidosis following removal of silicone gel breast implants"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46;S&#46; Teuber"
                            1 => "L&#46;P&#46; Howell"
                            2 => "S&#46;H&#46; Yoshida"
                            3 => "M&#46;E&#46; Gershwin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Int Arch Allergy Immunol"
                        "fecha" => "1994"
                        "volumen" => "105"
                        "paginaInicial" => "404"
                        "paginaFinal" => "407"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7981613"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010400000010/v1_201311281142/S1578219013002436/v1_201311281142/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6183"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case Reports"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010400000010/v1_201311281142/S1578219013002436/v1_201311281142/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013002436?idApp=UINPBA000044"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Case Report
Foreign Body Granulomatous Reaction to Silica, Silicone, and Hyaluronic Acid in a Patient With Interferon-Induced Sarcoidosis
Reacción granulomatosa a cuerpo extraño a sílice, silicona y ácido hialurónico, en paciente con sarcoidosis inducida por interferon
R. Novoaa, M.A. Barnadasa,
Corresponding author
MBarnadas@santpau.cat

Corresponding author.
, X. Torrasb, R. Curellc, A. Alomara
a Servicio de Dermatología, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
b Servicio de Digestivo, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
c Servicio de Anatomía Patológica, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Read
10645
Times
was read the article
3461
Total PDF
7184
Total HTML
Share statistics
 array:24 [
  "pii" => "S1578219013002436"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2012.07.037"
  "estado" => "S300"
  "fechaPublicacion" => "2013-12-01"
  "aid" => "697"
  "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
  "copyrightAnyo" => "2012"
  "documento" => "simple-article"
  "crossmark" => 0
  "subdocumento" => "crp"
  "cita" => "Actas Dermosifiliogr. 2013;104:920-3"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 3919
    "formatos" => array:3 [
      "EPUB" => 51
      "HTML" => 2859
      "PDF" => 1009
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0001731012003535"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2012.07.007"
      "estado" => "S300"
      "fechaPublicacion" => "2013-12-01"
      "aid" => "697"
      "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
      "documento" => "article"
      "crossmark" => 0
      "subdocumento" => "sco"
      "cita" => "Actas Dermosifiliogr. 2013;104:920-3"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 4658
        "formatos" => array:3 [
          "EPUB" => 2
          "HTML" => 3481
          "PDF" => 1175
        ]
      ]
      "es" => array:13 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Caso cl&#237;nico</span>"
        "titulo" => "Reacci&#243;n granulomatosa a cuerpo extra&#241;o a s&#237;lice&#44; silicona y &#225;cido hialur&#243;nico&#44; en paciente con sarcoidosis inducida por interfer&#243;n"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "tieneResumen" => array:2 [
          0 => "es"
          1 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "920"
            "paginaFinal" => "923"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Foreign Body Granulomatous Reaction to Silica&#44; Silicone&#44; and Hyaluronic Acid in a Patient With Interferon-Induced Sarcoidosis"
          ]
        ]
        "contieneResumen" => array:2 [
          "es" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0015"
            "etiqueta" => "Figura 3"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr3.jpeg"
                "Alto" => 645
                "Ancho" => 1750
                "Tamanyo" => 325508
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A&#41; El estudio histopatol&#243;gico del ganglio axilar izquierdo mostraba granulomas sarcoideos de forma difusa &#40;HE&#215;200&#41;&#46; B&#41; En el centro de la adenopat&#237;a se observaban vacuolas claras en el espacio extracelular y en el citoplasma de c&#233;lulas gigantes multinucleadas&#44; mostrando un material refr&#225;ctil en su interior &#40;HE&#215;400&#41;&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "R&#46; Novoa, M&#46;A&#46; Barnadas, X&#46; Torras, R&#46; Curell, A&#46; Alomar"
            "autores" => array:5 [
              0 => array:2 [
                "nombre" => "R&#46;"
                "apellidos" => "Novoa"
              ]
              1 => array:2 [
                "nombre" => "M&#46;A&#46;"
                "apellidos" => "Barnadas"
              ]
              2 => array:2 [
                "nombre" => "X&#46;"
                "apellidos" => "Torras"
              ]
              3 => array:2 [
                "nombre" => "R&#46;"
                "apellidos" => "Curell"
              ]
              4 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Alomar"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219013002436"
          "doi" => "10.1016/j.adengl.2012.07.037"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013002436?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012003535?idApp=UINPBA000044"
      "url" => "/00017310/0000010400000010/v1_201311281152/S0001731012003535/v1_201311281152/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1578219013002448"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2013.01.005"
    "estado" => "S300"
    "fechaPublicacion" => "2013-12-01"
    "aid" => "797"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2013;104:924-5"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3111
      "formatos" => array:3 [
        "EPUB" => 44
        "HTML" => 2616
        "PDF" => 451
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
      "titulo" => "Ulcerated Giant Pilomatrixoma in a Child"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "924"
          "paginaFinal" => "925"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Pilomatrixoma gigante y ulcerado en un ni&#241;o"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 952
              "Ancho" => 951
              "Tamanyo" => 146298
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Nuclear magnetic resonance imaging&#58; exophytic formation with a heterogeneous nodule surrounded by a hypointense halo and abundant vascularity in the stalk&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "P&#46; Stefano, S&#46; Apa, B&#46; Balancini"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Stefano"
            ]
            1 => array:2 [
              "nombre" => "S&#46;"
              "apellidos" => "Apa"
            ]
            2 => array:2 [
              "nombre" => "B&#46;"
              "apellidos" => "Balancini"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731013000197"
        "doi" => "10.1016/j.ad.2013.01.001"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731013000197?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013002448?idApp=UINPBA000044"
    "url" => "/15782190/0000010400000010/v1_201311281142/S1578219013002448/v1_201311281142/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1578219013002424"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2012.09.024"
    "estado" => "S300"
    "fechaPublicacion" => "2013-12-01"
    "aid" => "738"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "crp"
    "cita" => "Actas Dermosifiliogr. 2013;104:915-9"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 5640
      "formatos" => array:3 [
        "EPUB" => 69
        "HTML" => 4406
        "PDF" => 1165
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case Report</span>"
      "titulo" => "Erythema Nodosum Leprosum and Reversal Reaction in 2 Cases of Imported Leprosy"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "915"
          "paginaFinal" => "919"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Eritema nudoso leproso y reacci&#243;n de reversi&#243;n en 2 casos de lepra importada"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0015"
          "etiqueta" => "Figure 3"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr3.jpeg"
              "Alto" => 669
              "Ancho" => 900
              "Tamanyo" => 257951
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Lymphocytic&#44; neutrophilic&#44; and histiocytic infiltrate in the deep dermis in a patient with erythema nodosum leprosum &#40;hematoxylin-eosin&#44; original magnification &#215;40&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "A&#46; Pulido-P&#233;rez, M&#46;D&#46; Mendoza-Cembranos, J&#46;A&#46; Avil&#233;s-Izquierdo, R&#46; Su&#225;rez-Fern&#225;ndez"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Pulido-P&#233;rez"
            ]
            1 => array:2 [
              "nombre" => "M&#46;D&#46;"
              "apellidos" => "Mendoza-Cembranos"
            ]
            2 => array:2 [
              "nombre" => "J&#46;A&#46;"
              "apellidos" => "Avil&#233;s-Izquierdo"
            ]
            3 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Su&#225;rez-Fern&#225;ndez"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731012004553"
        "doi" => "10.1016/j.ad.2012.09.009"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012004553?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013002424?idApp=UINPBA000044"
    "url" => "/15782190/0000010400000010/v1_201311281142/S1578219013002424/v1_201311281142/en/main.assets"
  ]
  "en" => array:20 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case Report</span>"
    "titulo" => "Foreign Body Granulomatous Reaction to Silica&#44; Silicone&#44; and Hyaluronic Acid in a Patient With Interferon-Induced Sarcoidosis"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "920"
        "paginaFinal" => "923"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "R&#46; Novoa, M&#46;A&#46; Barnadas, X&#46; Torras, R&#46; Curell, A&#46; Alomar"
        "autores" => array:5 [
          0 => array:3 [
            "nombre" => "R&#46;"
            "apellidos" => "Novoa"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          1 => array:4 [
            "nombre" => "M&#46;A&#46;"
            "apellidos" => "Barnadas"
            "email" => array:1 [
              0 => "MBarnadas&#64;santpau&#46;cat"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "X&#46;"
            "apellidos" => "Torras"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "R&#46;"
            "apellidos" => "Curell"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "A&#46;"
            "apellidos" => "Alomar"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital de la Santa Creu i Sant Pau&#44; Barcelona&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Digestivo&#44; Centro de Investigaci&#243;n Biom&#233;dica en Red de Enfermedades Hep&#225;ticas y Digestivas&#44; Hospital de la Santa Creu i Sant Pau&#44; Barcelona&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Servicio de Anatom&#237;a Patol&#243;gica&#44; Hospital de la Santa Creu i Sant Pau&#44; Barcelona&#44; Spain"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Reacci&#243;n granulomatosa a cuerpo extra&#241;o a s&#237;lice&#44; silicona y &#225;cido hialur&#243;nico&#44; en paciente con sarcoidosis inducida por interferon"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 645
            "Ancho" => 1750
            "Tamanyo" => 337580
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A&#44; Histopathology of the left axillary lymph node showing widespread sarcoid granulomas &#40;hematoxylin and eosin&#44; original magnification&#44; &#215;200&#41;&#46; B&#44; The center of the node contains clear vacuoles in the extracellular space and in the cytoplasm of multinucleated giant cells&#46; Note the refractile material within these vacuoles &#40;hematoxylin and eosin&#44; original magnification&#44; &#215;400&#41;&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Sarcoidosis is more prevalent in patients receiving interferon than in the general population&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> Furthermore&#44; the appearance of granulomas in the skin is known to be related to the presence of foreign bodies&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> We describe the case of a patient with chronic hepatitis C who developed sarcoidosis while receiving treatment with pegylated interferon alfa combined with ribavirin&#46; The sarcoid granulomas were located in the skin and were associated with 3 different foreign bodies&#58; silica&#44; hyaluronic acid&#44; and silicone within a lymph node&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Case Description</span><p id="par0010" class="elsevierStylePara elsevierViewall">The patient was a 54-year-old woman who was referred to the dermatology department in September 2009 with erythematous-violaceous nodules on her face&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Important findings in her past history included silicone gel implants to both breasts 19 years previously &#40;these implants had not been replaced&#41; and chronic infection by hepatitis C virus &#40;HCV&#41;&#44; genotype 1b&#44; which had been detected 11 years earlier&#44; giving rise to severe liver fibrosis&#46; In September 2008 she started treatment with subcutaneous interferon alfa 2a &#40;180<span class="elsevierStyleHsp" style=""></span>&#956;g weekly&#41; combined with oral ribavirin &#40;1000<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#41;&#44; which led to a partial early virologic response&#46; Erythropoietin &#40;40&#160;000<span class="elsevierStyleHsp" style=""></span>IU&#41; was added at week 4 owing to anemia secondary to antiviral treatment&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Physical examination revealed erythematous-violaceous nodules in the interciliary sulci and nasolabial folds &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#44; A and B&#41;&#46; The patient reported that she had had hyaluronic acid injections at these sites 1 year earlier&#46; She had received treatment with intralesional corticosteroids but had shown no signs of improvement&#46; In addition&#44; she presented nodules covered by skin of normal appearance on both sides of her forehead in areas where she denied having had injections of hyaluronic acid&#46; She also presented brownish papules in a linear distribution on her left shoulder &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#44; elbows&#44; knees&#44; and in the proximity of old scars&#44; and the axillary lymph nodes were palpable bilaterally&#46; The patient reported having had dry cough and fever &#40;38<span class="elsevierStyleHsp" style=""></span>&#176;C&#41; during the previous month&#46; Laboratory tests revealed the following important results&#58; hemoglobin&#44; 10&#46;1<span class="elsevierStyleHsp" style=""></span>g&#47;dL&#59; white cell count&#44; 2330&#160;&#956;L&#59; and angiotensin-converting enzyme&#44; 80<span class="elsevierStyleHsp" style=""></span>U&#47;L &#40;reference range&#44; 20-60&#160;U&#47;L&#41;&#46; The results of the other laboratory tests&#8212;including renal and liver function and blood and urinary calcium and phosphate&#8212;were within the normal range&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Computed tomography of the chest and abdomen revealed changes in the breast implants&#44; which had acquired a nodular morphology&#44; and bilateral axillary lymphadenopathies&#44; as well as a 1-cm nodule in segment IV of the liver&#44; together with 2 other hepatic lesions measuring &#60;1<span class="elsevierStyleHsp" style=""></span>cm that were suggestive of cysts&#46; Magnetic resonance of the breasts revealed an intracapsular rupture of the implant on the left side&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Biopsy of a papule on the left shoulder showed epithelioid granulomas with no central necrosis in the papillary and upper reticular dermis&#44; surrounded by sparse lymphocytes &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>A&#41;&#46; Shiny particles were observed in the cytoplasm of some histiocytes and of some multinucleated giant cells &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>B&#41;&#46; These particles were birefringent with polarized light and were interpreted to be silica&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">Histopathology of an axillary lymph node revealed numerous nonnecrotizing sarcoid epithelioid granulomas &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>A&#41;&#46; In addition&#44; clear extracellular vacuoles of different sizes were present in the center of the node and there were abundant multinucleated giant cells with cytoplasmic vacuoles&#46; Nonbirefringent refractile material was observed inside some vacuoles&#46; Given that the patient had silicone breast implants&#44; this finding was compatible with silicone from the implants &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>B&#41;&#44; thus indicating silicone lymphadenopathy&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">A diagnosis of sarcoidosis was made&#46; As no visceral involvement was observed&#44; the same antiviral treatment was maintained&#46; However&#44; in November 2009&#44; hepatic cholestasis was detected &#40;alkaline phosphatase 245<span class="elsevierStyleHsp" style=""></span>U&#47;L &#91;reference range&#44; 35-110&#160;U&#47;L&#93; and gamma-glutamyltransferase 469<span class="elsevierStyleHsp" style=""></span>U&#47;L &#91;reference value&#44;<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>43&#160;U&#47;L&#93;&#41; and treatment with pegylated interferon alfa 2a and ribavirin was stopped&#46; The results of the laboratory tests subsequently returned to normal values&#44; the size of the cutaneous lesions gradually decreased&#44; and the cough and fever resolved&#46; In addition&#44; the virologic response was maintained 1 year after completing 60 weeks of antiviral treatment&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0045" class="elsevierStylePara elsevierViewall">Sarcoidosis is a multisystem granulomatous disease of unknown etiology that is sometimes associated with interferon administered to treat other diseases&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#8211;7</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Sarcoidosis is detected more frequently in HCV-infected patients than in the general population&#46; In their 2010 study&#44; Faurie et al&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> found a prevalence of 0&#46;12&#37; in a series of HCV-infected patients&#59; in the general population&#44; prevalence has been estimated to be between 1 and 40 cases per 100&#160;000&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> In 2005&#44; Ramos-Casals et al&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> reviewed 68 cases of sarcoidosis associated with chronic HCV infection and compared their findings with a control group of non&#8211;HCV-infected patients&#46; Those authors found that skin involvement in sarcoidosis was more frequent in HCV-infected patients &#40;56&#37;&#41; than in non&#8211;HCV-infected patients &#40;22&#37;&#41;&#46; In 4 cases&#44; the granulomas were adjacent to old scars and tattoos&#46; Faurie et al&#46; considered that sarcoidosis had been triggered by antiviral treatment in most cases &#40;79&#46;4&#37;&#41;&#46; The potential role of interferon could arise from the induction of a type 1 helper T-cell response&#44; which is thought to affect the formation of granulomas in patients with sarcoidosis&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Both pegylated and nonpegylated interferon alfa&#44; whether in monotherapy or in combination with ribavirin&#44; have been cited as possible triggers of sarcoidosis&#46; Prognosis is generally good in these cases&#44; and sarcoidosis can resolve spontaneously in 85&#37; of cases if antiviral treatment is stopped&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> In the case we report&#44; antiviral treatment was maintained until the onset of systemic manifestations&#46; At that time&#44; antiviral therapy was discontinued&#44; even though the 72-week regimen had not been completed&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">In the present case&#44; we think that sarcoidosis was probably induced by interferon and ribavirin for 2 reasons&#58; first&#44; the lesions appeared 11 months after starting treatment&#44; and second&#44; the skin and liver lesions&#44; the liver function tests&#44; angiotensin-converting enzyme levels&#44; and changes in the breast implants returned to normal once interferon was discontinued&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">We believe that the case we report is unusual&#44; as the sites of the sarcoid granulomas were associated with the presence of 3 foreign bodies &#40;silica&#44; hyaluronic acid&#44; and silicone&#41;&#46; The simultaneous onset of cutaneous sarcoid granulomas associated with 2 foreign bodies &#40;silica and silicone&#41; has been described elsewhere&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> Of note&#44; Marcoval et al&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> demonstrated the presence of foreign bodies in cutaneous granulomatous lesions in 22&#37; of 65 patients with systemic sarcoidosis and skin involvement and suggested that these foreign bodies could induce the formation of granulomas in patients with sarcoidosis&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">There have been reports of systemic sarcoidosis associated with tattoos<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> and fillers &#40;permanent and reabsorbable&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">10&#8211;12</span></a> Two studies<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#44;12</span></a> have reported sarcoid granulomas associated with injection of hyaluronic acid in 2 women&#58; one of those patients had hepatitis C treated with interferon&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">We report the first case of sarcoid granulomas developing in a silicone-induced lymphadenopathy&#46; This complication of breast implants is caused by migration of silicone to the lymph nodes&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> Sarcoidosis has been reported in patients with breast implants&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">14&#44;15</span></a> The condition improved spontaneously in 1 case&#44;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> and in the other&#44; the patient&#39;s condition improved dramatically after removal of the implants&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">We believe that sarcoidosis associated with HCV infection is of special interest for the dermatologist&#44; since it frequently affects the skin &#40;56&#37; of cases&#41;&#46; In addition&#44; cosmetic procedures such as tattoos and the use of fillers may induce the appearance of sarcoid granulomas in patients who develop sarcoidosis&#46; It has been suggested that the informed consent signed before cosmetic microimplant procedures should include the risk of severe interaction between the injected material and interferon or other immunostimulants&#44; were the patient to need such treatments in the future&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> This warning should be given even before injection of reabsorbable material&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Any changes in the areas where cosmetic materials have been injected should alert the dermatologist and cosmetic surgeon to a possible diagnosis of sarcoidosis&#44; especially in patients with HCV infection&#46; Furthermore&#44; before receiving cosmetic injections&#44; patients should be warned of the risk of developing or reactivating sarcoidosis in the future&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Ethical Disclosures</span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Protection of human and animal subjects</span><p id="par0085" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this investigation&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Confidentiality of data</span><p id="par0090" class="elsevierStylePara elsevierViewall">The authors declare that they followed their hospital&#39;s regulations regarding the publication of patient information and that written informed consent for voluntary participation was obtained for all patients&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Right to privacy and informed consent</span><p id="par0095" class="elsevierStylePara elsevierViewall">The authors declare that no private patient data are disclosed in this article&#46;</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conflicts of Interest</span><p id="par0100" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:10 [
        0 => array:2 [
          "identificador" => "xres295315"
          "titulo" => "Abstract"
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec279236"
          "titulo" => "Keywords"
        ]
        2 => array:2 [
          "identificador" => "xres295314"
          "titulo" => "Resumen"
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec279235"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Case Description"
        ]
        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Discussion"
        ]
        7 => array:3 [
          "identificador" => "sec0020"
          "titulo" => "Ethical Disclosures"
          "secciones" => array:3 [
            0 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "Protection of human and animal subjects"
            ]
            1 => array:2 [
              "identificador" => "sec0030"
              "titulo" => "Confidentiality of data"
            ]
            2 => array:2 [
              "identificador" => "sec0035"
              "titulo" => "Right to privacy and informed consent"
            ]
          ]
        ]
        8 => array:2 [
          "identificador" => "sec0040"
          "titulo" => "Conflicts of Interest"
        ]
        9 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2012-03-05"
    "fechaAceptado" => "2012-07-20"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec279236"
          "palabras" => array:8 [
            0 => "Sarcoidosis"
            1 => "Hepatitis C"
            2 => "Foreign-body granulomas"
            3 => "Silica"
            4 => "Silicone"
            5 => "Hyaluronic acid"
            6 => "Interferon"
            7 => "Silicone lymphadenopathy"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec279235"
          "palabras" => array:8 [
            0 => "Sarcoidosis"
            1 => "Hepatitis C"
            2 => "Granulomas a cuerpo extra&#241;o"
            3 => "S&#237;lice"
            4 => "Silicona"
            5 => "&#193;cido hialur&#243;nico"
            6 => "Interfer&#243;n"
            7 => "Linfadenopat&#237;a por silicona"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">We report the case of a patient who developed sarcoid granulomas 11 months after starting treatment with pegylated interferon alfa and ribavirin for chronic hepatitis C&#46; The sites of the lesions were related to 3 different foreign bodies&#58; silica in old scars on the skin&#44; hyaluronic acid that had been injected into facial tissues&#44; and silicone in an axillary lymph node draining the area of a breast implant&#46; Systemic sarcoidosis was diagnosed on the basis of a history of dry cough and fever and blood tests that revealed elevated angiotensin converting enzyme and liver enzymes&#46; Interruption of the antiviral therapy led to normalization of liver function tests and disappearance of the skin lesions and lymphadenopathies&#46; Dermatologists and cosmetic surgeons should be aware of the risk of sarcoid lesions related to cosmetic implants in patients who may require treatment with interferon in the future&#46;</p>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se describe el caso de una paciente que desarroll&#243; granulomas sarcoideos 11 meses despu&#233;s de haber iniciado interfer&#243;n &#945; pegilado y ribavirina&#44; como tratamiento de la hepatitis cr&#243;nica C&#46; Las lesiones se localizaban en relaci&#243;n a 3 cuerpos extra&#241;os diferentes&#58; s&#237;lice en cicatrices cut&#225;neas antiguas&#44; &#225;cido hialur&#243;nico que se hab&#237;a inyectado previamente en la cara&#44; y silicona que se detect&#243; en una adenopat&#237;a axilar donde hab&#237;a drenado de un implante mamario previo&#46; La paciente tambi&#233;n aquejaba tos seca&#44; fiebre y en la anal&#237;tica se detect&#243; un incremento de la enzima convertidora de angiotensina y de las enzimas hep&#225;ticas&#46; A partir de estos hallazgos se diagnostic&#243; de sarcoidosis sist&#233;mica y se suspendi&#243; el tratamiento antiviral con posterior normalizaci&#243;n de las pruebas hep&#225;ticas&#44; desaparici&#243;n de las lesiones cut&#225;neas y de las adenopat&#237;as&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Los dermat&#243;logos y cosmet&#243;logos deben ser conscientes del riesgo de aparici&#243;n de manifestaciones sarcoideas en las &#225;reas donde se han realizado implantes est&#233;ticos&#44; en los sujetos que en un futuro requieran tratamiento con interfer&#243;n&#46;</p>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Novoa R&#44; Barnadas MA&#44; Torras X&#44; Curell R&#44; Alomar A&#46; Reacci&#243;n granulomatosa a cuerpo extra&#241;o a s&#237;lice&#44; silicona y &#225;cido hialur&#243;nico&#44; en paciente con sarcoidosis inducida por interferon&#46; Actas Dermosifiliogr&#46; 2013&#59;104&#58;920&#8211;923&#46;</p>"
      ]
    ]
    "multimedia" => array:3 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 653
            "Ancho" => 1000
            "Tamanyo" => 118369
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">A&#44; Clinical appearance of nodules in a nasolabial fold&#46; B&#44; Clinical appearance of linear papules on an old scar&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 648
            "Ancho" => 1750
            "Tamanyo" => 326248
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">A&#44; Histopathology of a papule from the shoulder&#46; Sarcoid granulomas are visible in the reticular dermis &#40;hematoxylin and eosin&#44; original magnification&#44; &#215;200&#41;&#46; B&#44; Detail of shiny particles in the cytoplasm of multinucleated giant cells &#40;hematoxylin and eosin&#44; original magnification&#44; &#215;400&#41;&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 645
            "Ancho" => 1750
            "Tamanyo" => 337580
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A&#44; Histopathology of the left axillary lymph node showing widespread sarcoid granulomas &#40;hematoxylin and eosin&#44; original magnification&#44; &#215;200&#41;&#46; B&#44; The center of the node contains clear vacuoles in the extracellular space and in the cytoplasm of multinucleated giant cells&#46; Note the refractile material within these vacuoles &#40;hematoxylin and eosin&#44; original magnification&#44; &#215;400&#41;&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:15 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sarcoidosis in patients with chronic hepatitis C virus infection&#58; analysis of 68 cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Ramos-Casals"
                            1 => "J&#46; Ma&#241;&#225;"
                            2 => "N&#46; Nardi"
                            3 => "P&#46; Brito-Zer&#243;n"
                            4 => "A&#46; Xaubet"
                            5 => "J&#46;M&#46; S&#225;nchez Tapias"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Medicine"
                        "fecha" => "2005"
                        "volumen" => "84"
                        "paginaInicial" => "69"
                        "paginaFinal" => "80"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15758836"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sarcoidosis and hepatitis C&#58; clinical description of 11 cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "P&#46; Faurie"
                            1 => "C&#46; Broussolle"
                            2 => "F&#46; Zoulim"
                            3 => "C&#46; Trepo"
                            4 => "P&#46; S&#232;ve"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/MEG.0b013e32833834bc"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Gastroenterol Hepatol"
                        "fecha" => "2010"
                        "volumen" => "22"
                        "paginaInicial" => "967"
                        "paginaFinal" => "972"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20216423"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Foreign bodies in granulomatous cutaneous lesions of patients with systemic sarcoidosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46; Marcoval"
                            1 => "J&#46; Ma&#241;&#225;"
                            2 => "A&#46; Moreno"
                            3 => "I&#46; Gallego"
                            4 => "Y&#46; Fortuno"
                            5 => "J&#46; Peyr&#237;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "2001"
                        "volumen" => "137"
                        "paginaInicial" => "427"
                        "paginaFinal" => "430"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11295921"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pulmonary sarcoidosis following interferon therapy for advanced renal cell carcinoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "E&#46;A&#46; Abdi"
                            1 => "G&#46;K&#46; Nguyen"
                            2 => "R&#46;N&#46; Ludwig"
                            3 => "W&#46;J&#46; Dickout"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer"
                        "fecha" => "1987"
                        "volumen" => "59"
                        "paginaInicial" => "896"
                        "paginaFinal" => "900"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3815268"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interferon alpha therapy associated with the development of sarcoidosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46; Pietrapaoli"
                            1 => "J&#46; Modrak"
                            2 => "M&#46; Utell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1999"
                        "volumen" => "116"
                        "paginaInicial" => "569"
                        "paginaFinal" => "572"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10453892"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interferon-induced cutaneous sarcoidosis in melanoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "C&#46; Su&#225;rez-Garc&#237;a"
                            1 => "A&#46; P&#233;rez-Gil"
                            2 => "S&#46; Pereira-Gallardo"
                            3 => "M&#46; Codes-Villena"
                            4 => "A&#46; Garc&#237;a-Escudero"
                            5 => "F&#46; Miguel Camacho"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/CMR.0b013e32832f51f2"
                      "Revista" => array:6 [
                        "tituloSerie" => "Melanoma Res"
                        "fecha" => "2009"
                        "volumen" => "19"
                        "paginaInicial" => "391"
                        "paginaFinal" => "394"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19770687"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sarcoidosis following beta-interferon therapy for multiple myeloma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "E&#46; Bobbio-Pallavicini"
                            1 => "C&#46; Valsecchi"
                            2 => "F&#46; Tacconi"
                            3 => "M&#46; Moroni"
                            4 => "C&#46; Porta"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Sarcoidosis"
                        "fecha" => "1995"
                        "volumen" => "12"
                        "paginaInicial" => "140"
                        "paginaFinal" => "142"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8532962"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Simultaneous presentation of silicone and silica granuloma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "L&#46; Pimentel"
                            1 => "M&#46; Barnadas"
                            2 => "D&#46; Vidal"
                            3 => "F&#46; Sancho"
                            4 => "R&#46; Fontarnau"
                            5 => "A&#46; Alomar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "63897"
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatology"
                        "fecha" => "2002"
                        "volumen" => "205"
                        "paginaInicial" => "162"
                        "paginaFinal" => "165"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12218233"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Development of sarcoidosis in cosmetic tattoos"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46;D&#46; Antonovich"
                            1 => "J&#46;P&#46; Callen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/archderm.141.7.869"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "2005"
                        "volumen" => "141"
                        "paginaInicial" => "869"
                        "paginaFinal" => "872"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16027303"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cosmetic permanent fillers for soft tissue augmentation&#46; A new contraindication for interferon therapies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46; Fischer"
                            1 => "G&#46; Metzler"
                            2 => "M&#46; Schaller"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/archderm.143.4.507"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "2007"
                        "volumen" => "143"
                        "paginaInicial" => "507"
                        "paginaFinal" => "510"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17438184"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Facial cosmetic filler injections as possible target for systemic sarcoidosis in patients treated with interferon for chronic hepatitis C&#58; two cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "V&#46; Descamps"
                            1 => "J&#46; Landry"
                            2 => "C&#46; Franc&#233;s"
                            3 => "E&#46; Marinho"
                            4 => "V&#46; Ratziu"
                            5 => "O&#46; Chosidow"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000128281"
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatology"
                        "fecha" => "2008"
                        "volumen" => "217"
                        "paginaInicial" => "81"
                        "paginaFinal" => "84"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18446029"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Scar sarcoidosis after hyaluronic acid injection"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46; Dal Sacco"
                            1 => "E&#46; Cozzani"
                            2 => "A&#46; Parodi"
                            3 => "A&#46; Rebora"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-4632.2005.01930.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Dermatol"
                        "fecha" => "2005"
                        "volumen" => "44"
                        "paginaInicial" => "411"
                        "paginaFinal" => "412"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15869540"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Silicone lymphadenopathy associated with augmentation mammaplasty&#46; Morphologic features of nine cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "L&#46;D&#46; Truong"
                            1 => "J&#46; Cartwright Jr&#46;"
                            2 => "M&#46;D&#46; Goodman"
                            3 => "D&#46; Woznicki"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Surg Pathol"
                        "fecha" => "1988"
                        "volumen" => "12"
                        "paginaInicial" => "484"
                        "paginaFinal" => "491"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3377110"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous and pulmonary sarcoidosis in a Hong Kong Chinese woman with silicone breast prostheses"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "K&#46;C&#46; Chang"
                            1 => "K&#46;T&#46; Chan"
                            2 => "L&#46;Y&#46; Chong"
                            3 => "K&#46;S&#46; Lau"
                            4 => "C&#46;M&#46; Tam"
                            5 => "C&#46;W&#46; Lam"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Respirology"
                        "fecha" => "2003"
                        "volumen" => "8"
                        "paginaInicial" => "379"
                        "paginaFinal" => "382"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14528880"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Remission of sarcoidosis following removal of silicone gel breast implants"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46;S&#46; Teuber"
                            1 => "L&#46;P&#46; Howell"
                            2 => "S&#46;H&#46; Yoshida"
                            3 => "M&#46;E&#46; Gershwin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Int Arch Allergy Immunol"
                        "fecha" => "1994"
                        "volumen" => "105"
                        "paginaInicial" => "404"
                        "paginaFinal" => "407"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7981613"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010400000010/v1_201311281142/S1578219013002436/v1_201311281142/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6183"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case Reports"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010400000010/v1_201311281142/S1578219013002436/v1_201311281142/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013002436?idApp=UINPBA000044"
]
Article information
ISSN: 15782190
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 18 15 33
2024 October 114 58 172
2024 September 96 40 136
2024 August 126 63 189
2024 July 115 52 167
2024 June 143 47 190
2024 May 96 56 152
2024 April 99 34 133
2024 March 88 36 124
2024 February 89 39 128
2024 January 77 38 115
2023 December 70 24 94
2023 November 89 38 127
2023 October 106 33 139
2023 September 97 34 131
2023 August 61 34 95
2023 July 74 36 110
2023 June 64 29 93
2023 May 85 41 126
2023 April 72 44 116
2023 March 68 36 104
2023 February 50 28 78
2023 January 70 43 113
2022 December 72 36 108
2022 November 48 25 73
2022 October 59 35 94
2022 September 40 46 86
2022 August 18 60 78
2022 July 36 47 83
2022 June 61 36 97
2022 May 82 63 145
2022 April 107 69 176
2022 March 83 71 154
2022 February 64 36 100
2022 January 76 54 130
2021 December 45 53 98
2021 November 81 57 138
2021 October 126 76 202
2021 September 373 54 427
2021 August 112 32 144
2021 July 86 39 125
2021 June 79 61 140
2021 May 69 55 124
2021 April 104 95 199
2021 March 69 39 108
2021 February 56 38 94
2021 January 35 44 79
2020 December 57 46 103
2020 November 31 25 56
2020 October 41 21 62
2020 September 43 20 63
2020 August 33 49 82
2020 July 47 29 76
2020 June 36 42 78
2020 May 31 43 74
2020 April 33 30 63
2020 March 24 27 51
2020 February 1 7 8
2020 January 4 18 22
2019 December 6 10 16
2019 November 4 20 24
2019 October 0 8 8
2019 September 0 14 14
2019 August 6 14 20
2019 July 4 16 20
2019 June 4 19 23
2019 May 4 69 73
2019 April 2 60 62
2019 March 3 19 22
2019 February 0 21 21
2019 January 3 12 15
2018 December 1 11 12
2018 November 1 6 7
2018 October 2 8 10
2018 September 3 2 5
2018 August 0 7 7
2018 July 0 24 24
2018 June 0 15 15
2018 May 0 12 12
2018 April 0 11 11
2018 March 6 25 31
2018 February 76 10 86
2018 January 85 11 96
2017 December 91 12 103
2017 November 69 16 85
2017 October 64 12 76
2017 September 77 17 94
2017 August 87 29 116
2017 July 81 19 100
2017 June 87 28 115
2017 May 74 24 98
2017 April 92 21 113
2017 March 69 41 110
2017 February 53 15 68
2017 January 54 14 68
2016 December 54 14 68
2016 November 93 29 122
2016 October 138 25 163
2016 September 189 17 206
2016 August 87 13 100
2016 July 43 9 52
2016 June 8 6 14
2016 May 14 10 24
2016 April 8 10 18
2016 March 12 1 13
2016 February 10 1 11
2016 January 12 2 14
2015 December 8 2 10
2015 November 7 10 17
2015 October 6 3 9
2015 September 3 1 4
2015 August 6 1 7
2015 July 72 5 77
2015 June 70 9 79
2015 May 76 9 85
2015 April 51 8 59
2015 March 54 10 64
2015 February 67 14 81
2015 January 60 5 65
2014 December 51 5 56
2014 November 58 7 65
2014 October 52 10 62
2014 September 36 7 43
2014 August 37 7 44
2014 July 37 8 45
2014 June 62 9 71
2014 May 45 8 53
2014 April 54 6 60
2014 March 50 9 59
2014 February 45 6 51
2014 January 36 5 41
2013 December 35 10 45
2013 November 1 2 3
Show all

Follow this link to access the full text of the article

Idiomas
Actas Dermo-Sifiliográficas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?