Case and Research Letters
Fox-Fordyce Disease With an Atypical Clinical Presentation
Enfermedad de Fox-Fordyce con presentación clínica atípica
Servicio de Dermatología, Hospital Universitario Sta. María del Rosell de Cartagena, Murcia, Spain
Read
8461
Timeswas read the article
2827
Total PDF
5634
Total HTML
Share statistics
array:24 [ "pii" => "S1578219013002199" "issn" => "15782190" "doi" => "10.1016/j.adengl.2012.10.015" "estado" => "S300" "fechaPublicacion" => "2013-11-01" "aid" => "752" "copyright" => "Elsevier España, S.L. and AEDV" "copyrightAnyo" => "2012" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "cor" "cita" => "Actas Dermosifiliogr. 2013;104:832-4" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2737 "formatos" => array:3 [ "EPUB" => 33 "HTML" => 2005 "PDF" => 699 ] ] "Traduccion" => array:1 [ "es" => array:19 [ "pii" => "S0001731012004826" "issn" => "00017310" "doi" => "10.1016/j.ad.2012.10.008" "estado" => "S300" "fechaPublicacion" => "2013-11-01" "aid" => "752" "copyright" => "Elsevier España, S.L. y AEDV" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "cor" "cita" => "Actas Dermosifiliogr. 2013;104:832-4" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 5047 "formatos" => array:3 [ "EPUB" => 2 "HTML" => 2414 "PDF" => 2631 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Carta científico-clínica</span>" "titulo" => "Enfermedad de Fox-Fordyce con presentación clínica atípica" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "832" "paginaFinal" => "834" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Fox-Fordyce Disease With an Atypical Clinical Presentation" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1432 "Ancho" => 2175 "Tamanyo" => 322320 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A. Pápulas múltiples milimétricas eritemato-amarillentas no confluyentes localizadas en en la región torácica y en el abdomen. B. No presentaba afectación axilar.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "I. Ballester, Á. López-Ávila, S. Ortiz" "autores" => array:3 [ 0 => array:2 [ "nombre" => "I." "apellidos" => "Ballester" ] 1 => array:2 [ "nombre" => "Á." "apellidos" => "López-Ávila" ] 2 => array:2 [ "nombre" => "S." "apellidos" => "Ortiz" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S1578219013002199" "doi" => "10.1016/j.adengl.2012.10.015" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013002199?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012004826?idApp=UINPBA000044" "url" => "/00017310/0000010400000009/v1_201310240057/S0001731012004826/v1_201310240057/es/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S1578219013002205" "issn" => "15782190" "doi" => "10.1016/j.adengl.2012.10.016" "estado" => "S300" "fechaPublicacion" => "2013-11-01" "aid" => "754" "copyright" => "Elsevier España, S.L. and AEDV" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "cor" "cita" => "Actas Dermosifiliogr. 2013;104:834-5" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3336 "formatos" => array:3 [ "EPUB" => 39 "HTML" => 2485 "PDF" => 812 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>" "titulo" => "Whitish Plaque on the Soft Palate" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "834" "paginaFinal" => "835" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Placa blanquecina en el paladar blando" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1001 "Ancho" => 1333 "Tamanyo" => 132461 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Irregular whitish plaque on the soft palate.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "G. Solano-López, D. de Argila, J. Fraga, A. García-Diez" "autores" => array:4 [ 0 => array:2 [ "nombre" => "G." "apellidos" => "Solano-López" ] 1 => array:2 [ "nombre" => "D." "apellidos" => "de Argila" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "Fraga" ] 3 => array:2 [ "nombre" => "A." "apellidos" => "García-Diez" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S000173101200484X" "doi" => "10.1016/j.ad.2012.10.010" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S000173101200484X?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013002205?idApp=UINPBA000044" "url" => "/15782190/0000010400000009/v1_201310240051/S1578219013002205/v1_201310240051/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S1578219013002187" "issn" => "15782190" "doi" => "10.1016/j.adengl.2012.10.014" "estado" => "S300" "fechaPublicacion" => "2013-11-01" "aid" => "744" "copyright" => "Elsevier España, S.L. and AEDV" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "cor" "cita" => "Actas Dermosifiliogr. 2013;104:830-2" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 6946 "formatos" => array:3 [ "EPUB" => 38 "HTML" => 5803 "PDF" => 1105 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>" "titulo" => "Periungual Acral Fibrokeratoma: Surgical Excision Using a Banner Flap" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "830" "paginaFinal" => "832" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Fibroqueratoma acral periungueal: exéresis quirúrgica en bandera" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1000 "Ancho" => 1333 "Tamanyo" => 178356 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Banner flap: 2 longitudinal incisions are made into the proximal nail fold, one on either side of the lesion.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "O. Yélamos, M. Alegre, J.R. Garcés, L. Puig" "autores" => array:4 [ 0 => array:2 [ "nombre" => "O." "apellidos" => "Yélamos" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Alegre" ] 2 => array:2 [ "nombre" => "J.R." "apellidos" => "Garcés" ] 3 => array:2 [ "nombre" => "L." "apellidos" => "Puig" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731012004747" "doi" => "10.1016/j.ad.2012.10.001" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012004747?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013002187?idApp=UINPBA000044" "url" => "/15782190/0000010400000009/v1_201310240051/S1578219013002187/v1_201310240051/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>" "titulo" => "Fox-Fordyce Disease With an Atypical Clinical Presentation" "tieneTextoCompleto" => true "saludo" => "<span class="elsevierStyleItalic">To the Editor:</span>" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "832" "paginaFinal" => "834" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "I. Ballester, Á. López-Ávila, S. Ortiz" "autores" => array:3 [ 0 => array:4 [ "nombre" => "I." "apellidos" => "Ballester" "email" => array:1 [ 0 => "ibalnor@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Á." "apellidos" => "López-Ávila" ] 2 => array:2 [ "nombre" => "S." "apellidos" => "Ortiz" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Dermatología, Hospital Universitario Sta. María del Rosell de Cartagena, Murcia, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Enfermedad de Fox-Fordyce con presentación clínica atípica" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1991 "Ancho" => 1665 "Tamanyo" => 1014894 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Dilatation and hyperkeratotic plugging of the follicular infundibulum surrounded by an abundance of xanthomized macrophages (hematoxylin-eosin, original magnification ×50).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Fox-Fordyce disease (FFD), or apocrine miliaria, is a rare inflammatory disease of the apocrine glands characterized by the presence of pruritic follicular papules in apocrine-rich areas of the skin. We present a case of histologically confirmed FFD with extensive involvement of 2 unusual sites, the chest and abdomen.</p><p id="par0010" class="elsevierStylePara elsevierViewall">A 39-year-old woman was referred for evaluation of an asymptomatic rash that had appeared 2 years earlier. There was no significant personal or family medical history. The rash had first appeared in the presternal area and had then spread over the abdomen to the pubic region. The rash consisted of multiple minute nonconfluent red-to-yellow papules on the breasts and especially the lower chest and abdomen, as far as the pubic region (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). The axillae, areolae, and genitals were uninvolved.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Histologic examination of a papule from the lower presternal region revealed dilatation and hyperkeratotic plugging of the follicular infundibulum, which was surrounded by abundant foamy histiocytes (xanthomized macrophages) (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>); a mild-to-moderate periadnexal chronic lymphocytic inflammatory response; and clusters of apocrine cells, with a tendency to cystic dilatation, between the reticular dermis and hypodermis (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>).</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">There were no relevant findings in the blood panel and the basic hormone panel, which included testosterone, dehydroepiandrosterone sulfate, progesterone, estradiol, luteinizing hormone, and follicle-stimulating hormone.</p><p id="par0025" class="elsevierStylePara elsevierViewall">No improvement was noted after successive attempts at topical treatment with tretinoin, corticosteroids, and clindamycin.</p><p id="par0030" class="elsevierStylePara elsevierViewall">FFD was first described by Fox and Fordyce in 1902.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> This rare skin condition is most common in women aged 13 to 35 years. The etiology and pathogenesis of FFD are unknown, although genetic, endocrine, environmental, and metabolic factors have been proposed.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Plugging of the apocrine duct at its point of entry in the follicular infundibulum appears to be the chief factor involved in the development of FFD. Plugging is thought to cause secretions to accumulate and then extravasate into the infundibulum and the peri-infundibular dermis, leading to a secondary inflammatory response that largely consists of macrophage recruitment.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Clinical presentation usually includes multiple white-to-yellow follicular papules symmetrically located in characteristic regions with an abundance of apocrine glands.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Lesions are frequently pruritic and worsen in the summer months and at times of emotional stress. Involved areas show little body hair growth and no sweating.</p><p id="par0040" class="elsevierStylePara elsevierViewall">FFD chiefly manifests in areas rich in apocrine glands: the axillae, mammary areolae, periumbilical region, mons pubis, labia minora, scrotum, foreskin, perianal region, free margins of the eyelids, and external ears. Apocrine glands are sparsely present in all other skin regions, especially the trunk and head,<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> but FFD has only occasionally been reported in sites other than those listed. Unusual reported locations include the presternal and periumbilical regions and internal surface of the thighs.<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6,7</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">The defining histopathologic features of FFD vary widely. Descriptions include dilatation and hyperkeratosis of the follicular infundibulum, spongiosis and dyskeratosis of the infundibular epithelium, vacuolar degeneration of the dermoepidermal junction, presence of periadnexal inflammatory lymphocytic infiltrate, parakeratosis of the infundibular epithelium in the form of cornoid lamellae, dilatation of the apocrine glands, and perifollicular xanthomatosis. The last is considered among the most characteristic findings.<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3,8,9</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Generally speaking, treatment of FFD is less than satisfactory, and the condition is typically chronic.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> Treatment approaches used with varying results include topical and intralesional corticosteroids, topical or systemic retinoids, topical antibiotics (such as clindamycin), oral contraceptives, and topical pimecrolimus.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> Highly refractory cases have sometimes led to surgical treatment, including electrocoagulation, excision, and liposuction.</p><p id="par0055" class="elsevierStylePara elsevierViewall">In conclusion, we believe that FFD should be considered in the differential diagnosis of any progressive rash of red-to-yellow papules on the chest or abdomen. Clinically similar, easily confused conditions more frequently described at these sites include syringomas, steatocystoma multiplex, or lichen nitidus, and distinguishing them from FFD requires the correlation of both clinical and histologic findings.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Ballester I, López-Ávila Á, Ortiz S. Enfermedad de Fox-Fordyce con presentación clínica atípica. Actas Dermosifiliogr. 2013;104:832–834.</p>" ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1432 "Ancho" => 2175 "Tamanyo" => 351123 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A, Multiple minute nonconfluent red-to-yellow papules on the chest and abdomen. B, The axillae were not involved.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1991 "Ancho" => 1665 "Tamanyo" => 1014894 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Dilatation and hyperkeratotic plugging of the follicular infundibulum surrounded by an abundance of xanthomized macrophages (hematoxylin-eosin, original magnification ×50).</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 2082 "Ancho" => 1665 "Tamanyo" => 1001142 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Chronic periadnexal lymphocytic inflammatory infiltrate and dilated clusters of apocrine cells (hematoxylin-eosin, original magnification ×50).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Two cases of a rare papular disease affecting the axillary region" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G.H. Fox" 1 => "J.A. Fordyce" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Cut Genito-Urinary Dis" "fecha" => "1902" "volumen" => "20" "paginaInicial" => "1" "paginaFinal" => "5" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fox-Fordyce disease in monozygotic female twins" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M.M. Guiotoku" 1 => "P.T. Lopes" 2 => "M.E. Marques" 3 => "S.A. Marques" 4 => "H.A. Miot" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2009.11.591" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2011" "volumen" => "65" "paginaInicial" => "229" "paginaFinal" => "230" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21679831" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Patterns histopathologic of Fox-Fordyce disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A. Böer" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Dermatopathol" "fecha" => "2004" "volumen" => "26" "paginaInicial" => "482" "paginaFinal" => "492" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15618931" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fox-Fordyce disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A. Ozcan" 1 => "M. Senol" 2 => "N.E. Aydin" 3 => "S. Karaca" 4 => "S. Sener" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Eur Acad Dermatol Venereol" "fecha" => "2003" "volumen" => "17" "paginaInicial" => "244" "paginaFinal" => "245" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12705772" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "La glándula ecrina y la glándula apocrina de la piel humana normal" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "P. Simón" 1 => "E. Sánchez-Yus" 2 => "L. Requena" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:3 [ "titulo" => "Neoplasias anexiales cutáneas" "paginaInicial" => "3" "serieFecha" => "2004" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Zouboulis C, Tsatsou F. Trastorno de las glándulas sudoríparas apocrinas. In: Wolff, Goldsmith, Katz, Gilchrest, Paller, Leffell, editors. Fitzpatrick. Dermatología en Medicina General. 7.<span class="elsevierStyleSup">a</span> ed. Buenos Aires: Editorial Médica Panamericana. p.733-34." ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Miller JL, Hurley HJ. Diseases of the eccrine and apocrine sweat glands. In: Bolognia JL, Jorizzo JL, Rapini RP, editors. Dermatology. 2nd ed. Spain: Mosby Elsevier. p. 547." ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dilation of apocrine glands. A forgotten but helpful histopathological clue to the diagnosis of axillary Fox-Fordyce disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R.S. Macarenco" 1 => "S.J.C. Garces" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/DAD.0b013e318197b7fd" "Revista" => array:6 [ "tituloSerie" => "Am J Dermatopathol" "fecha" => "2009" "volumen" => "31" "paginaInicial" => "393" "paginaFinal" => "397" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19461248" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Xantomatosis perifolicular: hallazgo histológico clave en la enfermedad de Fox-Fordyce" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J. Mataix" 1 => "J.F. Silvestre" 2 => "M. Niveiro" 3 => "A. Lucas" 4 => "M. Pérez-Crespo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2008" "volumen" => "99" "paginaInicial" => "145" "paginaFinal" => "148" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18346437" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical effects of topical pimecrolimus in a patient with Fox-Fordyce disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D. Milcic" 1 => "M. Nikolic" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1440-0960.2010.00711.x" "Revista" => array:6 [ "tituloSerie" => "Australas J Dermatol" "fecha" => "2012" "volumen" => "53" "paginaInicial" => "e34" "paginaFinal" => "e35" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22571582" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010400000009/v1_201310240051/S1578219013002199/v1_201310240051/en/main.assets" "Apartado" => array:4 [ "identificador" => "6157" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Case and Research Letters" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010400000009/v1_201310240051/S1578219013002199/v1_201310240051/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013002199?idApp=UINPBA000044" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 10 | 6 | 16 |
| 2024 October | 84 | 47 | 131 |
| 2024 September | 94 | 33 | 127 |
| 2024 August | 131 | 70 | 201 |
| 2024 July | 102 | 60 | 162 |
| 2024 June | 110 | 65 | 175 |
| 2024 May | 86 | 39 | 125 |
| 2024 April | 66 | 34 | 100 |
| 2024 March | 101 | 31 | 132 |
| 2024 February | 84 | 35 | 119 |
| 2024 January | 86 | 31 | 117 |
| 2023 December | 83 | 18 | 101 |
| 2023 November | 81 | 39 | 120 |
| 2023 October | 81 | 25 | 106 |
| 2023 September | 72 | 36 | 108 |
| 2023 August | 44 | 45 | 89 |
| 2023 July | 92 | 60 | 152 |
| 2023 June | 54 | 48 | 102 |
| 2023 May | 90 | 59 | 149 |
| 2023 April | 71 | 38 | 109 |
| 2023 March | 83 | 54 | 137 |
| 2023 February | 67 | 42 | 109 |
| 2023 January | 73 | 50 | 123 |
| 2022 December | 72 | 55 | 127 |
| 2022 November | 34 | 49 | 83 |
| 2022 October | 38 | 36 | 74 |
| 2022 September | 37 | 49 | 86 |
| 2022 August | 46 | 53 | 99 |
| 2022 July | 32 | 28 | 60 |
| 2022 June | 35 | 37 | 72 |
| 2022 May | 72 | 45 | 117 |
| 2022 April | 67 | 28 | 95 |
| 2022 March | 76 | 41 | 117 |
| 2022 February | 44 | 20 | 64 |
| 2022 January | 54 | 43 | 97 |
| 2021 December | 53 | 39 | 92 |
| 2021 November | 74 | 57 | 131 |
| 2021 October | 68 | 49 | 117 |
| 2021 September | 43 | 40 | 83 |
| 2021 August | 97 | 29 | 126 |
| 2021 July | 69 | 42 | 111 |
| 2021 June | 64 | 41 | 105 |
| 2021 May | 54 | 45 | 99 |
| 2021 April | 93 | 62 | 155 |
| 2021 March | 87 | 30 | 117 |
| 2021 February | 88 | 33 | 121 |
| 2021 January | 42 | 18 | 60 |
| 2020 December | 43 | 20 | 63 |
| 2020 November | 32 | 17 | 49 |
| 2020 October | 34 | 13 | 47 |
| 2020 September | 29 | 18 | 47 |
| 2020 August | 35 | 23 | 58 |
| 2020 July | 36 | 19 | 55 |
| 2020 June | 38 | 26 | 64 |
| 2020 May | 36 | 23 | 59 |
| 2020 April | 27 | 17 | 44 |
| 2020 March | 31 | 16 | 47 |
| 2020 February | 4 | 3 | 7 |
| 2020 January | 0 | 1 | 1 |
| 2019 December | 0 | 8 | 8 |
| 2019 October | 0 | 5 | 5 |
| 2019 September | 0 | 8 | 8 |
| 2019 August | 0 | 6 | 6 |
| 2019 July | 1 | 25 | 26 |
| 2019 June | 10 | 42 | 52 |
| 2019 May | 2 | 52 | 54 |
| 2019 April | 9 | 65 | 74 |
| 2019 March | 1 | 33 | 34 |
| 2019 February | 5 | 21 | 26 |
| 2019 January | 2 | 3 | 5 |
| 2018 December | 3 | 6 | 9 |
| 2018 November | 5 | 2 | 7 |
| 2018 October | 15 | 2 | 17 |
| 2018 September | 4 | 4 | 8 |
| 2018 August | 0 | 15 | 15 |
| 2018 July | 0 | 13 | 13 |
| 2018 June | 0 | 7 | 7 |
| 2018 May | 0 | 10 | 10 |
| 2018 April | 0 | 3 | 3 |
| 2018 March | 17 | 2 | 19 |
| 2018 February | 40 | 5 | 45 |
| 2018 January | 45 | 8 | 53 |
| 2017 December | 50 | 9 | 59 |
| 2017 November | 41 | 5 | 46 |
| 2017 October | 58 | 2 | 60 |
| 2017 September | 47 | 8 | 55 |
| 2017 August | 39 | 4 | 43 |
| 2017 July | 27 | 6 | 33 |
| 2017 June | 53 | 29 | 82 |
| 2017 May | 23 | 5 | 28 |
| 2017 April | 23 | 7 | 30 |
| 2017 March | 25 | 28 | 53 |
| 2017 February | 82 | 8 | 90 |
| 2017 January | 29 | 11 | 40 |
| 2016 December | 58 | 12 | 70 |
| 2016 November | 89 | 10 | 99 |
| 2016 October | 122 | 19 | 141 |
| 2016 September | 166 | 9 | 175 |
| 2016 August | 132 | 18 | 150 |
| 2016 July | 50 | 8 | 58 |
| 2016 June | 6 | 17 | 23 |
| 2016 May | 6 | 11 | 17 |
| 2016 April | 4 | 1 | 5 |
| 2016 March | 5 | 1 | 6 |
| 2016 February | 11 | 4 | 15 |
| 2016 January | 13 | 3 | 16 |
| 2015 December | 7 | 0 | 7 |
| 2015 November | 6 | 2 | 8 |
| 2015 October | 4 | 2 | 6 |
| 2015 September | 4 | 2 | 6 |
| 2015 August | 5 | 2 | 7 |
| 2015 July | 33 | 3 | 36 |
| 2015 June | 28 | 6 | 34 |
| 2015 May | 46 | 14 | 60 |
| 2015 April | 28 | 7 | 35 |
| 2015 March | 30 | 7 | 37 |
| 2015 February | 29 | 2 | 31 |
| 2015 January | 37 | 3 | 40 |
| 2014 December | 44 | 2 | 46 |
| 2014 November | 21 | 1 | 22 |
| 2014 October | 43 | 8 | 51 |
| 2014 September | 41 | 5 | 46 |
| 2014 August | 23 | 7 | 30 |
| 2014 July | 27 | 5 | 32 |
| 2014 June | 29 | 3 | 32 |
| 2014 May | 44 | 10 | 54 |
| 2014 April | 36 | 5 | 41 |
| 2014 March | 34 | 7 | 41 |
| 2014 February | 28 | 4 | 32 |
| 2014 January | 29 | 4 | 33 |
| 2013 December | 22 | 4 | 26 |
| 2013 November | 9 | 2 | 11 |
Show all
