array:24 [
  "pii" => "S1578219013001844"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2012.07.034"
  "estado" => "S300"
  "fechaPublicacion" => "2013-10-01"
  "aid" => "725"
  "copyright" => "Elsevier España, S.L. and AEDV"
  "copyrightAnyo" => "2012"
  "documento" => "simple-article"
  "crossmark" => 0
  "subdocumento" => "cor"
  "cita" => "Actas Dermosifiliogr. 2013;104:724-5"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 3971
    "formatos" => array:3 [
      "EPUB" => 44
      "HTML" => 3276
      "PDF" => 651
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0001731012004425"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2012.07.021"
      "estado" => "S300"
      "fechaPublicacion" => "2013-10-01"
      "aid" => "725"
      "copyright" => "Elsevier España, S.L. y AEDV"
      "documento" => "simple-article"
      "crossmark" => 0
      "subdocumento" => "cor"
      "cita" => "Actas Dermosifiliogr. 2013;104:724-5"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 3535
        "formatos" => array:3 [
          "EPUB" => 2
          "HTML" => 2747
          "PDF" => 786
        ]
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta cient&#237;fico-cl&#237;nica</span>"
        "titulo" => "Dermatomiositis del adulto asociada a lipodistrofia"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "724"
            "paginaFinal" => "725"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Adult Dermatomyositis Associated With Lipodystrophy"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 735
                "Ancho" => 900
                "Tamanyo" => 92517
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Eritema palpebral y p&#233;rdida de tejido graso en ambas mejillas&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "M&#46; Pretel, M&#46; Navedo, L&#46; Marqu&#233;s, L&#46; Aguado"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "M&#46;"
                "apellidos" => "Pretel"
              ]
              1 => array:2 [
                "nombre" => "M&#46;"
                "apellidos" => "Navedo"
              ]
              2 => array:2 [
                "nombre" => "L&#46;"
                "apellidos" => "Marqu&#233;s"
              ]
              3 => array:2 [
                "nombre" => "L&#46;"
                "apellidos" => "Aguado"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219013001844"
          "doi" => "10.1016/j.adengl.2012.07.034"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013001844?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012004425?idApp=UINPBA000044"
      "url" => "/00017310/0000010400000008/v1_201309240051/S0001731012004425/v1_201309240051/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1578219013001881"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2012.07.035"
    "estado" => "S300"
    "fechaPublicacion" => "2013-10-01"
    "aid" => "723"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2013;104:725-7"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1140
      "formatos" => array:3 [
        "EPUB" => 37
        "HTML" => 689
        "PDF" => 414
      ]
    ]
    "en" => array:8 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
      "titulo" => "Photodynamic Therapy With Methyl-aminolevulinate can be Useful in the Management of Scytalidium Infections"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "725"
          "paginaFinal" => "727"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "La terapia fotodin&#225;mica con metilaminolevulinato puede ser &#250;til en el manejo de las infecciones por Scytalidium"
        ]
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S0001731012004401"
        "doi" => "10.1016/j.ad.2012.07.020"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012004401?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013001881?idApp=UINPBA000044"
    "url" => "/15782190/0000010400000008/v1_201309240048/S1578219013001881/v1_201309240048/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1578219013001832"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2012.09.023"
    "estado" => "S300"
    "fechaPublicacion" => "2013-10-01"
    "aid" => "728"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2013;104:721-4"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3427
      "formatos" => array:3 [
        "EPUB" => 41
        "HTML" => 2757
        "PDF" => 629
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
      "titulo" => "Superficial Granulomatous Pyoderma&#46; Report of 2 Cases Treated With Topical Tacrolimus"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "721"
          "paginaFinal" => "724"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Pioderma granulomatoso superficial&#46; Presentaci&#243;n de 2 casos tratados con tacrolimus t&#243;pico"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1221
              "Ancho" => 1584
              "Tamanyo" => 176373
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A&#44; Plaques with ulcers on the buttocks&#46; B&#44; Horseshoe-shaped ulcer measuring 7<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleHsp" style=""></span>cm with an atrophic center and erythematous-violaceous borders on the upper back&#46; C&#44; Predominantly follicular inflammatory infiltrate with rupture of the follicular epithelium and granulomatous reaction with giant cells &#40;hematoxylin-eosin&#44; original magnification &#215;100&#41;&#46; D&#44; Residual scars on the buttocks&#46; E&#44; cribriform scars on the back&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "N&#46; Ormaechea-P&#233;rez, A&#46; L&#243;pez-Pesta&#241;a, C&#46; Lobo-Mor&#225;n, A&#46; Tuneu-Valls"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "N&#46;"
              "apellidos" => "Ormaechea-P&#233;rez"
            ]
            1 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "L&#243;pez-Pesta&#241;a"
            ]
            2 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Lobo-Mor&#225;n"
            ]
            3 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Tuneu-Valls"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731012004450"
        "doi" => "10.1016/j.ad.2012.09.004"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012004450?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013001832?idApp=UINPBA000044"
    "url" => "/15782190/0000010400000008/v1_201309240048/S1578219013001832/v1_201309240048/en/main.assets"
  ]
  "en" => array:14 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
    "titulo" => "Adult Dermatomyositis Associated With Lipodystrophy"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "724"
        "paginaFinal" => "725"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "M&#46; Pretel, M&#46; Navedo, L&#46; Marqu&#233;s, L&#46; Aguado"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "M&#46;"
            "apellidos" => "Pretel"
            "email" => array:1 [
              0 => "mpretel&#64;unav&#46;es"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "M&#46;"
            "apellidos" => "Navedo"
          ]
          2 => array:2 [
            "nombre" => "L&#46;"
            "apellidos" => "Marqu&#233;s"
          ]
          3 => array:2 [
            "nombre" => "L&#46;"
            "apellidos" => "Aguado"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Departamento de Dermatolog&#237;a&#44; Cl&#237;nica Universidad de Navarra&#44; Pamplona&#44; Navarra&#44; Spain"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Dermatomiositis del adulto asociada a lipodistrofia"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 644
            "Ancho" => 900
            "Tamanyo" => 72305
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Atrophic erythematous lesions in the interphalangeal joints of the fingers&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0065" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">To the Editor&#58;</span></p><p id="par0005" class="elsevierStylePara elsevierViewall">Lipodystrophy is a rare disease characterized by loss of adipose tissue that can be associated with metabolic disorders and autoimmune diseases&#44; primarily juvenile dermatomyositis&#46; Lipodystrophy in association with adult-onset dermatomyositis&#44; however&#44; is very rare&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">A 23-year-old woman consulted for erythema and bilateral palpebral edema that had appeared 1 year earlier and skin lesions on the dorsum of the interphalangeal joints of both hands&#46; The patient reported that she had experienced muscle pain and weakness over the last 6 months&#44; as well as joint pain in her hands&#44; wrists&#44; elbows&#44; and knees&#46; She also mentioned a progressive loss of fat in the facial region and arms over the last 2 months&#46; The patient had no past history of interest and was not taking any medication&#46; She also reported no family history of connective tissue disease&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">In the physical examination&#44; we observed a marked loss of adipose tissue in the face and arms&#59; the trunk and lower limbs were unaffected by this loss &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; There were atrophic erythematous lesions on the skin of the elbows and interphalangeal joints of the fingers &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; We also detected the presence of periorbital erythema and periungual telangiectasia &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; The patient had rigidity in the joints of the hands&#44; with no signs of arthritis&#44; and proximal muscle weakness &#40;grade 4-5 according to the Medical Research Council scale&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">The blood tests showed normal levels of creatine kinase and aldolase&#46; The results of the antinuclear antibody test were positive&#44; with a titer of 1&#58;320 and a granular pattern&#46; The C3 and C4 fractions of the complement were within normal limits&#46; The anti-Jo1&#44; anti-Ro&#44; anti-La&#44; anti-nRNP&#44; anti-Sm&#44; anti-ssDNA and anti-dsDNA antibody test results were negative&#46; We detected no abnormalities in serum lipid or glucose levels&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Biopsy of the hand lesions showed lichenoid dermatitis with hydropic degeneration of the basement membrane and upper dermal edema&#46; There were no immunoglobulin &#40;Ig&#41; G&#44; IgA&#44; fibrinogen&#44; or complement deposits in the direct immunofluorescence assay&#46; An electrophysiological study showed no abnormalities&#46; We therefore performed a muscle biopsy&#44; which revealed muscle fiber necrosis and a lymphoplasmacytic inflammatory infiltrate&#46; Magnetic resonance imaging showed thickening of the perimuscular fascia of the arms&#44; shoulders&#44; buttocks&#44; and thighs&#46; Based on the above findings&#44; we arrived at the diagnosis of dermatomyositis&#46; Given this diagnosis in an adult&#44; we followed up with positron emission tomography&#44; which ruled out underlying neoplastic disease at the time of the visit and 2 years later&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Lipodystrophy is a rare disease characterized by the loss of subcutaneous adipose tissue&#46; It is classified as inherited or acquired and&#44; depending on its location&#44; as generalized&#44; partial &#40;relatively extensive but not generalized&#41;&#44; or localized&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> When lipodystrophy is generalized or partial&#44; it is often associated with metabolic disorders&#44; such as insulin resistance and hypertriglyceridemia&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Acquired lipodystrophy has been associated with infections&#44; antiretroviral therapy for the treatment of human immunodeficiency virus infection and with autoimmune diseases such as rheumatoid arthritis&#44; systemic lupus erythematosus&#44; Sj&#246;gren syndrome&#44; and dermatomyositis&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Dermatomyositis &#40;specifically&#44; juvenile dermatomyositis&#41; is the autoimmune disease most frequently related to the development of lipodystrophy&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The prevalence of lipodystrophy in juvenile dermatomyositis varies among studies from 10&#37; to 40&#37;&#46; In the only study performed with a large number of patients&#44; acquired lipodystrophy was observed in 8&#37; of patients with juvenile dermatomyositis&#44; while only 1 of the 692 adult patients with dermatomyositis had lipodystrophy&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> To date&#44; only 2 cases of lipodystrophy associated with adult-onset dermatomyositis have been published&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a> The reasons for this lack of association are unknown&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">One study has shown that a number of manifestations of dermatomyositis&#44; such as joint rigidity&#44; muscle atrophy&#44; panniculitis&#44; and calcinosis&#44; could be related to the development of lipodystrophy&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Of all these signs&#44; our patient had only joint rigidity in the hands&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The etiology and pathogenesis of lipodystrophy associated with autoimmune disease remain unclear&#46; Patients with partial lipodystrophy often have low C3 levels&#44; which may trigger the alternative complement pathway and promote development of the disease&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">The majority of patients described in the literature developed lipodystrophy years after the onset of dermatomyositis&#44; as a late complication of severe&#44; chronic disease&#59; our patient&#44; however&#44; developed symptoms of dermatomyositis and lipodystrophy practically simultaneously&#46; In contrast to what occurs in most cases of partial lipodystrophy&#44; there were no metabolic abnormalities in our patient&#46; We were also unable to demonstrate etiologic or pathogenic mechanisms associated with immunologic abnormalities such as low levels of C3&#46; In agreement with reports from similar cases in the literature&#44;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a> treatment with oral prednisone and mycophenolate mofetil did not improve the facial lipoatrophy in our patient&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">We have presented a very rare case of adult lipoatrophy simultaneously associated with dermatomyositis&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Based on published data&#44; it would be prudent to closely monitor all patients with dermatomyositis who develop a loss of subcutaneous fat in order to progressively rule out abnormalities in the metabolism of lipids and carbohydrates&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Pretel M&#44; et al&#46; Dermatomiositis del adulto asociada a lipodistrofia&#46; Actas Dermosifiliogr&#46; 2013&#59;104&#58;724&#8211;5&#46;</p>"
      ]
    ]
    "multimedia" => array:3 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 735
            "Ancho" => 900
            "Tamanyo" => 92517
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Palpebral erythema and loss of fatty tissue in both cheeks&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 644
            "Ancho" => 900
            "Tamanyo" => 72305
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Atrophic erythematous lesions in the interphalangeal joints of the fingers&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 672
            "Ancho" => 900
            "Tamanyo" => 43610
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Periungual telangiectasias observed with capillaroscopy&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:6 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acquired and inherited lipodystrophies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "A&#46; Garg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMra025261"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2004"
                        "volumen" => "350"
                        "paginaInicial" => "1220"
                        "paginaFinal" => "1234"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15028826"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical features and metabolic and autoimmune derangements in acquired partial lipodystrophy&#58; report of 35 cases and review of the literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46; Misra"
                            1 => "A&#46; Peethambaram"
                            2 => "A&#46; Garg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Medicine &#40;Baltimore&#41;"
                        "fecha" => "2004"
                        "volumen" => "83"
                        "paginaInicial" => "18"
                        "paginaFinal" => "34"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Childhood acquired lipodystrophy&#58; a retrospective study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "E&#46; Pope"
                            1 => "A&#46; Janson"
                            2 => "A&#46; Khambalia"
                            3 => "B&#46; Feldman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2006.05.005"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2006"
                        "volumen" => "55"
                        "paginaInicial" => "947"
                        "paginaFinal" => "950"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17097389"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Childhood Myositis Heterogeneity Study Group&#44; predictors of acquired lipodystrophy in juvenile-onset dermatomyositis and a gradient of severity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Bingham"
                            1 => "G&#46; Mamyrova"
                            2 => "K&#46;I&#46; Rother"
                            3 => "E&#46; Oral"
                            4 => "E&#46; Cochran"
                            5 => "A&#46; Premkumar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Medicine &#40;Baltimore&#41;"
                        "fecha" => "2008"
                        "volumen" => "87"
                        "paginaInicial" => "70"
                        "paginaFinal" => "86"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lipodystrophy and metabolic abnormalities in a case of adult dermatomyositis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "L&#46;A&#46; Lee"
                            1 => "K&#46;F&#46; Hobbs"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2007"
                        "volumen" => "57"
                        "paginaInicial" => "85"
                        "paginaFinal" => "87"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lipodystrophy in association with adult-onset dermatomyositis sine myositis&#58; a rare manifestation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "E&#46;N&#46; Le"
                            1 => "R&#46; Abuav"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2010"
                        "volumen" => "63"
                        "paginaInicial" => "46"
                        "paginaFinal" => "48"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010400000008/v1_201309240048/S1578219013001844/v1_201309240048/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6157"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case and Research Letters"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010400000008/v1_201309240048/S1578219013001844/v1_201309240048/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013001844?idApp=UINPBA000044"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Case and Research Letter
Adult Dermatomyositis Associated With Lipodystrophy
Dermatomiositis del adulto asociada a lipodistrofia
M. Pretel
Corresponding author
mpretel@unav.es

Corresponding author.
, M. Navedo, L. Marqués, L. Aguado
Departamento de Dermatología, Clínica Universidad de Navarra, Pamplona, Navarra, Spain
Read
11144
Times
was read the article
3471
Total PDF
7673
Total HTML
Share statistics
 array:24 [
  "pii" => "S1578219013001844"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2012.07.034"
  "estado" => "S300"
  "fechaPublicacion" => "2013-10-01"
  "aid" => "725"
  "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
  "copyrightAnyo" => "2012"
  "documento" => "simple-article"
  "crossmark" => 0
  "subdocumento" => "cor"
  "cita" => "Actas Dermosifiliogr. 2013;104:724-5"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 3971
    "formatos" => array:3 [
      "EPUB" => 44
      "HTML" => 3276
      "PDF" => 651
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0001731012004425"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2012.07.021"
      "estado" => "S300"
      "fechaPublicacion" => "2013-10-01"
      "aid" => "725"
      "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; y AEDV"
      "documento" => "simple-article"
      "crossmark" => 0
      "subdocumento" => "cor"
      "cita" => "Actas Dermosifiliogr. 2013;104:724-5"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 3535
        "formatos" => array:3 [
          "EPUB" => 2
          "HTML" => 2747
          "PDF" => 786
        ]
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta cient&#237;fico-cl&#237;nica</span>"
        "titulo" => "Dermatomiositis del adulto asociada a lipodistrofia"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "724"
            "paginaFinal" => "725"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Adult Dermatomyositis Associated With Lipodystrophy"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 735
                "Ancho" => 900
                "Tamanyo" => 92517
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Eritema palpebral y p&#233;rdida de tejido graso en ambas mejillas&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "M&#46; Pretel, M&#46; Navedo, L&#46; Marqu&#233;s, L&#46; Aguado"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "M&#46;"
                "apellidos" => "Pretel"
              ]
              1 => array:2 [
                "nombre" => "M&#46;"
                "apellidos" => "Navedo"
              ]
              2 => array:2 [
                "nombre" => "L&#46;"
                "apellidos" => "Marqu&#233;s"
              ]
              3 => array:2 [
                "nombre" => "L&#46;"
                "apellidos" => "Aguado"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219013001844"
          "doi" => "10.1016/j.adengl.2012.07.034"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013001844?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012004425?idApp=UINPBA000044"
      "url" => "/00017310/0000010400000008/v1_201309240051/S0001731012004425/v1_201309240051/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1578219013001881"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2012.07.035"
    "estado" => "S300"
    "fechaPublicacion" => "2013-10-01"
    "aid" => "723"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2013;104:725-7"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1140
      "formatos" => array:3 [
        "EPUB" => 37
        "HTML" => 689
        "PDF" => 414
      ]
    ]
    "en" => array:8 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
      "titulo" => "Photodynamic Therapy With Methyl-aminolevulinate can be Useful in the Management of Scytalidium Infections"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "725"
          "paginaFinal" => "727"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "La terapia fotodin&#225;mica con metilaminolevulinato puede ser &#250;til en el manejo de las infecciones por Scytalidium"
        ]
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S0001731012004401"
        "doi" => "10.1016/j.ad.2012.07.020"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012004401?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013001881?idApp=UINPBA000044"
    "url" => "/15782190/0000010400000008/v1_201309240048/S1578219013001881/v1_201309240048/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1578219013001832"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2012.09.023"
    "estado" => "S300"
    "fechaPublicacion" => "2013-10-01"
    "aid" => "728"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2013;104:721-4"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3427
      "formatos" => array:3 [
        "EPUB" => 41
        "HTML" => 2757
        "PDF" => 629
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
      "titulo" => "Superficial Granulomatous Pyoderma&#46; Report of 2 Cases Treated With Topical Tacrolimus"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "721"
          "paginaFinal" => "724"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Pioderma granulomatoso superficial&#46; Presentaci&#243;n de 2 casos tratados con tacrolimus t&#243;pico"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1221
              "Ancho" => 1584
              "Tamanyo" => 176373
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A&#44; Plaques with ulcers on the buttocks&#46; B&#44; Horseshoe-shaped ulcer measuring 7<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleHsp" style=""></span>cm with an atrophic center and erythematous-violaceous borders on the upper back&#46; C&#44; Predominantly follicular inflammatory infiltrate with rupture of the follicular epithelium and granulomatous reaction with giant cells &#40;hematoxylin-eosin&#44; original magnification &#215;100&#41;&#46; D&#44; Residual scars on the buttocks&#46; E&#44; cribriform scars on the back&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "N&#46; Ormaechea-P&#233;rez, A&#46; L&#243;pez-Pesta&#241;a, C&#46; Lobo-Mor&#225;n, A&#46; Tuneu-Valls"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "N&#46;"
              "apellidos" => "Ormaechea-P&#233;rez"
            ]
            1 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "L&#243;pez-Pesta&#241;a"
            ]
            2 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Lobo-Mor&#225;n"
            ]
            3 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Tuneu-Valls"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731012004450"
        "doi" => "10.1016/j.ad.2012.09.004"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012004450?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013001832?idApp=UINPBA000044"
    "url" => "/15782190/0000010400000008/v1_201309240048/S1578219013001832/v1_201309240048/en/main.assets"
  ]
  "en" => array:14 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
    "titulo" => "Adult Dermatomyositis Associated With Lipodystrophy"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "724"
        "paginaFinal" => "725"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "M&#46; Pretel, M&#46; Navedo, L&#46; Marqu&#233;s, L&#46; Aguado"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "M&#46;"
            "apellidos" => "Pretel"
            "email" => array:1 [
              0 => "mpretel&#64;unav&#46;es"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "M&#46;"
            "apellidos" => "Navedo"
          ]
          2 => array:2 [
            "nombre" => "L&#46;"
            "apellidos" => "Marqu&#233;s"
          ]
          3 => array:2 [
            "nombre" => "L&#46;"
            "apellidos" => "Aguado"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Departamento de Dermatolog&#237;a&#44; Cl&#237;nica Universidad de Navarra&#44; Pamplona&#44; Navarra&#44; Spain"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Dermatomiositis del adulto asociada a lipodistrofia"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 644
            "Ancho" => 900
            "Tamanyo" => 72305
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Atrophic erythematous lesions in the interphalangeal joints of the fingers&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0065" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">To the Editor&#58;</span></p><p id="par0005" class="elsevierStylePara elsevierViewall">Lipodystrophy is a rare disease characterized by loss of adipose tissue that can be associated with metabolic disorders and autoimmune diseases&#44; primarily juvenile dermatomyositis&#46; Lipodystrophy in association with adult-onset dermatomyositis&#44; however&#44; is very rare&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">A 23-year-old woman consulted for erythema and bilateral palpebral edema that had appeared 1 year earlier and skin lesions on the dorsum of the interphalangeal joints of both hands&#46; The patient reported that she had experienced muscle pain and weakness over the last 6 months&#44; as well as joint pain in her hands&#44; wrists&#44; elbows&#44; and knees&#46; She also mentioned a progressive loss of fat in the facial region and arms over the last 2 months&#46; The patient had no past history of interest and was not taking any medication&#46; She also reported no family history of connective tissue disease&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">In the physical examination&#44; we observed a marked loss of adipose tissue in the face and arms&#59; the trunk and lower limbs were unaffected by this loss &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; There were atrophic erythematous lesions on the skin of the elbows and interphalangeal joints of the fingers &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; We also detected the presence of periorbital erythema and periungual telangiectasia &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; The patient had rigidity in the joints of the hands&#44; with no signs of arthritis&#44; and proximal muscle weakness &#40;grade 4-5 according to the Medical Research Council scale&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">The blood tests showed normal levels of creatine kinase and aldolase&#46; The results of the antinuclear antibody test were positive&#44; with a titer of 1&#58;320 and a granular pattern&#46; The C3 and C4 fractions of the complement were within normal limits&#46; The anti-Jo1&#44; anti-Ro&#44; anti-La&#44; anti-nRNP&#44; anti-Sm&#44; anti-ssDNA and anti-dsDNA antibody test results were negative&#46; We detected no abnormalities in serum lipid or glucose levels&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Biopsy of the hand lesions showed lichenoid dermatitis with hydropic degeneration of the basement membrane and upper dermal edema&#46; There were no immunoglobulin &#40;Ig&#41; G&#44; IgA&#44; fibrinogen&#44; or complement deposits in the direct immunofluorescence assay&#46; An electrophysiological study showed no abnormalities&#46; We therefore performed a muscle biopsy&#44; which revealed muscle fiber necrosis and a lymphoplasmacytic inflammatory infiltrate&#46; Magnetic resonance imaging showed thickening of the perimuscular fascia of the arms&#44; shoulders&#44; buttocks&#44; and thighs&#46; Based on the above findings&#44; we arrived at the diagnosis of dermatomyositis&#46; Given this diagnosis in an adult&#44; we followed up with positron emission tomography&#44; which ruled out underlying neoplastic disease at the time of the visit and 2 years later&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Lipodystrophy is a rare disease characterized by the loss of subcutaneous adipose tissue&#46; It is classified as inherited or acquired and&#44; depending on its location&#44; as generalized&#44; partial &#40;relatively extensive but not generalized&#41;&#44; or localized&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> When lipodystrophy is generalized or partial&#44; it is often associated with metabolic disorders&#44; such as insulin resistance and hypertriglyceridemia&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Acquired lipodystrophy has been associated with infections&#44; antiretroviral therapy for the treatment of human immunodeficiency virus infection and with autoimmune diseases such as rheumatoid arthritis&#44; systemic lupus erythematosus&#44; Sj&#246;gren syndrome&#44; and dermatomyositis&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Dermatomyositis &#40;specifically&#44; juvenile dermatomyositis&#41; is the autoimmune disease most frequently related to the development of lipodystrophy&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The prevalence of lipodystrophy in juvenile dermatomyositis varies among studies from 10&#37; to 40&#37;&#46; In the only study performed with a large number of patients&#44; acquired lipodystrophy was observed in 8&#37; of patients with juvenile dermatomyositis&#44; while only 1 of the 692 adult patients with dermatomyositis had lipodystrophy&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> To date&#44; only 2 cases of lipodystrophy associated with adult-onset dermatomyositis have been published&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a> The reasons for this lack of association are unknown&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">One study has shown that a number of manifestations of dermatomyositis&#44; such as joint rigidity&#44; muscle atrophy&#44; panniculitis&#44; and calcinosis&#44; could be related to the development of lipodystrophy&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Of all these signs&#44; our patient had only joint rigidity in the hands&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The etiology and pathogenesis of lipodystrophy associated with autoimmune disease remain unclear&#46; Patients with partial lipodystrophy often have low C3 levels&#44; which may trigger the alternative complement pathway and promote development of the disease&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">The majority of patients described in the literature developed lipodystrophy years after the onset of dermatomyositis&#44; as a late complication of severe&#44; chronic disease&#59; our patient&#44; however&#44; developed symptoms of dermatomyositis and lipodystrophy practically simultaneously&#46; In contrast to what occurs in most cases of partial lipodystrophy&#44; there were no metabolic abnormalities in our patient&#46; We were also unable to demonstrate etiologic or pathogenic mechanisms associated with immunologic abnormalities such as low levels of C3&#46; In agreement with reports from similar cases in the literature&#44;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a> treatment with oral prednisone and mycophenolate mofetil did not improve the facial lipoatrophy in our patient&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">We have presented a very rare case of adult lipoatrophy simultaneously associated with dermatomyositis&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Based on published data&#44; it would be prudent to closely monitor all patients with dermatomyositis who develop a loss of subcutaneous fat in order to progressively rule out abnormalities in the metabolism of lipids and carbohydrates&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Pretel M&#44; et al&#46; Dermatomiositis del adulto asociada a lipodistrofia&#46; Actas Dermosifiliogr&#46; 2013&#59;104&#58;724&#8211;5&#46;</p>"
      ]
    ]
    "multimedia" => array:3 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 735
            "Ancho" => 900
            "Tamanyo" => 92517
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Palpebral erythema and loss of fatty tissue in both cheeks&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 644
            "Ancho" => 900
            "Tamanyo" => 72305
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Atrophic erythematous lesions in the interphalangeal joints of the fingers&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 672
            "Ancho" => 900
            "Tamanyo" => 43610
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Periungual telangiectasias observed with capillaroscopy&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:6 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acquired and inherited lipodystrophies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "A&#46; Garg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMra025261"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2004"
                        "volumen" => "350"
                        "paginaInicial" => "1220"
                        "paginaFinal" => "1234"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15028826"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical features and metabolic and autoimmune derangements in acquired partial lipodystrophy&#58; report of 35 cases and review of the literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46; Misra"
                            1 => "A&#46; Peethambaram"
                            2 => "A&#46; Garg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Medicine &#40;Baltimore&#41;"
                        "fecha" => "2004"
                        "volumen" => "83"
                        "paginaInicial" => "18"
                        "paginaFinal" => "34"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Childhood acquired lipodystrophy&#58; a retrospective study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "E&#46; Pope"
                            1 => "A&#46; Janson"
                            2 => "A&#46; Khambalia"
                            3 => "B&#46; Feldman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2006.05.005"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2006"
                        "volumen" => "55"
                        "paginaInicial" => "947"
                        "paginaFinal" => "950"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17097389"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Childhood Myositis Heterogeneity Study Group&#44; predictors of acquired lipodystrophy in juvenile-onset dermatomyositis and a gradient of severity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Bingham"
                            1 => "G&#46; Mamyrova"
                            2 => "K&#46;I&#46; Rother"
                            3 => "E&#46; Oral"
                            4 => "E&#46; Cochran"
                            5 => "A&#46; Premkumar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Medicine &#40;Baltimore&#41;"
                        "fecha" => "2008"
                        "volumen" => "87"
                        "paginaInicial" => "70"
                        "paginaFinal" => "86"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lipodystrophy and metabolic abnormalities in a case of adult dermatomyositis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "L&#46;A&#46; Lee"
                            1 => "K&#46;F&#46; Hobbs"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2007"
                        "volumen" => "57"
                        "paginaInicial" => "85"
                        "paginaFinal" => "87"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lipodystrophy in association with adult-onset dermatomyositis sine myositis&#58; a rare manifestation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "E&#46;N&#46; Le"
                            1 => "R&#46; Abuav"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2010"
                        "volumen" => "63"
                        "paginaInicial" => "46"
                        "paginaFinal" => "48"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010400000008/v1_201309240048/S1578219013001844/v1_201309240048/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6157"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case and Research Letters"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010400000008/v1_201309240048/S1578219013001844/v1_201309240048/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013001844?idApp=UINPBA000044"
]
Article information
ISSN: 15782190
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 15 11 26
2024 October 105 53 158
2024 September 138 31 169
2024 August 166 94 260
2024 July 129 42 171
2024 June 152 45 197
2024 May 142 48 190
2024 April 125 36 161
2024 March 129 48 177
2024 February 105 47 152
2024 January 116 43 159
2023 December 119 56 175
2023 November 121 62 183
2023 October 104 33 137
2023 September 102 65 167
2023 August 85 38 123
2023 July 106 68 174
2023 June 80 40 120
2023 May 111 61 172
2023 April 120 56 176
2023 March 106 58 164
2023 February 84 45 129
2023 January 67 43 110
2022 December 77 49 126
2022 November 33 59 92
2022 October 41 36 77
2022 September 45 64 109
2022 August 30 64 94
2022 July 41 55 96
2022 June 29 49 78
2022 May 60 48 108
2022 April 71 70 141
2022 March 60 64 124
2022 February 53 44 97
2022 January 55 81 136
2021 December 56 67 123
2021 November 78 60 138
2021 October 81 84 165
2021 September 81 76 157
2021 August 78 63 141
2021 July 98 50 148
2021 June 69 49 118
2021 May 53 45 98
2021 April 120 54 174
2021 March 87 62 149
2021 February 68 40 108
2021 January 55 30 85
2020 December 48 27 75
2020 November 25 18 43
2020 October 30 41 71
2020 September 37 40 77
2020 August 25 30 55
2020 July 27 26 53
2020 June 46 35 81
2020 May 36 50 86
2020 April 38 37 75
2020 March 35 24 59
2020 February 10 19 29
2020 January 2 26 28
2019 December 8 17 25
2019 November 2 2 4
2019 October 4 11 15
2019 September 8 8 16
2019 August 4 8 12
2019 July 4 8 12
2019 June 6 10 16
2019 May 4 49 53
2019 April 3 1 4
2019 March 2 7 9
2019 February 4 0 4
2018 December 2 0 2
2018 November 1 0 1
2018 October 3 2 5
2018 September 2 1 3
2018 August 0 5 5
2018 July 0 3 3
2018 June 0 2 2
2018 May 0 6 6
2018 April 0 1 1
2018 March 16 11 27
2018 February 105 9 114
2018 January 131 8 139
2017 December 109 10 119
2017 November 84 4 88
2017 October 59 10 69
2017 September 72 12 84
2017 August 80 7 87
2017 July 54 18 72
2017 June 73 29 102
2017 May 75 23 98
2017 April 63 10 73
2017 March 78 22 100
2017 February 69 17 86
2017 January 72 13 85
2016 December 71 9 80
2016 November 131 13 144
2016 October 192 28 220
2016 September 245 11 256
2016 August 195 4 199
2016 July 87 9 96
2016 June 12 9 21
2016 May 11 6 17
2016 April 5 3 8
2016 March 3 22 25
2016 February 6 1 7
2016 January 10 4 14
2015 December 11 17 28
2015 November 19 2 21
2015 October 16 15 31
2015 September 5 3 8
2015 August 9 8 17
2015 July 138 8 146
2015 June 61 3 64
2015 May 71 4 75
2015 April 48 12 60
2015 March 44 3 47
2015 February 56 6 62
2015 January 50 1 51
2014 December 40 6 46
2014 November 46 6 52
2014 October 53 7 60
2014 September 48 2 50
2014 August 39 3 42
2014 July 44 5 49
2014 June 61 5 66
2014 May 59 5 64
2014 April 38 6 44
2014 March 53 6 59
2014 February 41 4 45
2014 January 32 2 34
2013 December 16 3 19
2013 November 1 4 5
2013 October 2 3 5
2013 September 2 0 2
Show all

Follow this link to access the full text of the article

Idiomas
Actas Dermo-Sifiliográficas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?