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The patient was a 53-year-old man who consulted for a back lesion that had grown progressively over the previous 6 years&#46; A previous biopsy performed at another center had shown an infiltrate composed of atypical lymphocytes with positivity for T-cell markers and abundant CD30<span class="elsevierStyleSup">&#43;</span> cells&#46; The suspected diagnosis was mycosis fungoides with CD30<span class="elsevierStyleSup">&#43;</span> cells&#46; No additional immunohistochemical information was available&#46; A staging study consisting of computed tomography &#40;CT&#41; of the chest and abdomen and routine blood tests was normal&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Physical examination revealed several tumors and plaques surrounded by erythematous macules in the lumbar region and on the left flank &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; There were no signs of organomegaly or lymph node enlargement&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">A biopsy performed at our center showed a nodular lymphoid proliferation with a tendency to coalesce extending throughout the dermis and into the hypodermis&#44; with no evidence of epidermotropism &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; The lesion was composed of medium and large B cells that were positive for CD20 and CD79 and negative for CD3&#44; CD10&#44; CD23&#44; and CD43&#59; there were also&#44; however&#44; abundant CD3<span class="elsevierStyleSup">&#43;</span>&#44; CD5<span class="elsevierStyleSup">&#43;</span>&#44; and CD7<span class="elsevierStyleSup">&#43;</span> T cells &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; Immunostaining was positive for bcl-6 in the large cells and in some of the smaller cells&#46; There was also bcl-2 positivity&#44; but this was difficult to interpret due to the presence of large number of T cells&#46; The cells were negative for CD30&#44; contrasting with the results from the previous biopsy&#46; Approximately 15&#37; of the cells were positive for Ki67&#46; Immunogenotyping revealed clonal rearrangement of immunoglobulin heavy locus &#40;<span class="elsevierStyleItalic">IHG</span>&#41; genes and a lack of T-cell receptor gene &#40;<span class="elsevierStyleItalic">TCR</span>&#41; rearrangement&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">On the basis of these findings&#44; we ordered a staging study consisting of general blood tests &#40;including analysis of lactic acid dehydrogenase and &#946;-2 microglobulin levels&#41;&#44; a chest and abdomen CT scan&#44; and a bone marrow biopsy&#46; The results were all normal&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The main entity considered in the differential diagnosis was marginal zone B-cell lymphoma which&#44; unlike cutaneous FCL&#44; tends to be bcl-6-negative&#46; We also considered diffuse large B-cell lymphoma&#44; leg-type&#44; but this is characterized by a diffuse monomorphous infiltrate with large numbers of large bcl-2<span class="elsevierStyleSup">&#43;</span> and MUM-1<span class="elsevierStyleSup">&#43;</span> cells&#46; Because of the large number of T cells observed&#44; we also initially considered mycosis fungoides and pseudolymphoma&#44; but ruled these out on the basis of the clinical presentation&#44; the type of infiltrate&#44; the presence of <span class="elsevierStyleItalic">IGH</span> clonal rearrangement&#44; and the lack of <span class="elsevierStyleItalic">TCR</span> clonal rearrangement<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> &#40;although it should be noted that <span class="elsevierStyleItalic">TCR</span> clonal rearrangement is not always detected in early mycosis fungoides<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a>&#41;&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">On correlating clinical and pathologic findings&#44; Crosti lymphoma was considered the most likely diagnosis&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> This classic variant of cutaneous FCL is characterized by a B-cell infiltrate with follicle center cells and a variable number of centroblasts that may be accompanied by abundant reactive T cells&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Pan B-cell markers and germinal center markers tend to be positive&#44; but the latter may be negative in FCL with a diffuse growth pattern&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Unlike in follicular lymphoma of nodal origin&#44; cells in Crosti lymphoma are normally not immunoreactive for bcl-2&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;6</span></a> Up to 15&#37; of primary cutaneous FCLs&#44; however&#44; express bcl-6 &#40;as was the case with our patient&#41;&#44; and this aids diagnosis&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Following the recommendations of the European Organisation for Research and Treatment of Cancer&#44;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> we initiated treatment with local radiation therapy&#46; This led to resolution of the lesions and there were no signs of recurrence after 8 months of follow-up&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">We have described a case diagnosed as Crosti lymphoma&#44; 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Cases and Research Letters
Cutaneous B-cell Lymphoma: The Importance of Clinicopathologic Correlation
Linfoma de células B cutáneo: relevancia de la correlación clínico-patológica
L. Morella,
Corresponding author
laiamorell@hotmail.com

Corresponding author.
, J. Bassas-Vilaa, J.L. Mateb, I. Bielsaa
a Servicio de Dermatología, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain
b Servicio de Anatomía Patológica, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain
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The patient was a 53-year-old man who consulted for a back lesion that had grown progressively over the previous 6 years&#46; A previous biopsy performed at another center had shown an infiltrate composed of atypical lymphocytes with positivity for T-cell markers and abundant CD30<span class="elsevierStyleSup">&#43;</span> cells&#46; The suspected diagnosis was mycosis fungoides with CD30<span class="elsevierStyleSup">&#43;</span> cells&#46; No additional immunohistochemical information was available&#46; A staging study consisting of computed tomography &#40;CT&#41; of the chest and abdomen and routine blood tests was normal&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Physical examination revealed several tumors and plaques surrounded by erythematous macules in the lumbar region and on the left flank &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; There were no signs of organomegaly or lymph node enlargement&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">A biopsy performed at our center showed a nodular lymphoid proliferation with a tendency to coalesce extending throughout the dermis and into the hypodermis&#44; with no evidence of epidermotropism &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; The lesion was composed of medium and large B cells that were positive for CD20 and CD79 and negative for CD3&#44; CD10&#44; CD23&#44; and CD43&#59; there were also&#44; however&#44; abundant CD3<span class="elsevierStyleSup">&#43;</span>&#44; CD5<span class="elsevierStyleSup">&#43;</span>&#44; and CD7<span class="elsevierStyleSup">&#43;</span> T cells &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; Immunostaining was positive for bcl-6 in the large cells and in some of the smaller cells&#46; There was also bcl-2 positivity&#44; but this was difficult to interpret due to the presence of large number of T cells&#46; The cells were negative for CD30&#44; contrasting with the results from the previous biopsy&#46; Approximately 15&#37; of the cells were positive for Ki67&#46; Immunogenotyping revealed clonal rearrangement of immunoglobulin heavy locus &#40;<span class="elsevierStyleItalic">IHG</span>&#41; genes and a lack of T-cell receptor gene &#40;<span class="elsevierStyleItalic">TCR</span>&#41; rearrangement&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">On the basis of these findings&#44; we ordered a staging study consisting of general blood tests &#40;including analysis of lactic acid dehydrogenase and &#946;-2 microglobulin levels&#41;&#44; a chest and abdomen CT scan&#44; and a bone marrow biopsy&#46; The results were all normal&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The main entity considered in the differential diagnosis was marginal zone B-cell lymphoma which&#44; unlike cutaneous FCL&#44; tends to be bcl-6-negative&#46; We also considered diffuse large B-cell lymphoma&#44; leg-type&#44; but this is characterized by a diffuse monomorphous infiltrate with large numbers of large bcl-2<span class="elsevierStyleSup">&#43;</span> and MUM-1<span class="elsevierStyleSup">&#43;</span> cells&#46; Because of the large number of T cells observed&#44; we also initially considered mycosis fungoides and pseudolymphoma&#44; but ruled these out on the basis of the clinical presentation&#44; the type of infiltrate&#44; the presence of <span class="elsevierStyleItalic">IGH</span> clonal rearrangement&#44; and the lack of <span class="elsevierStyleItalic">TCR</span> clonal rearrangement<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> &#40;although it should be noted that <span class="elsevierStyleItalic">TCR</span> clonal rearrangement is not always detected in early mycosis fungoides<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a>&#41;&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">On correlating clinical and pathologic findings&#44; Crosti lymphoma was considered the most likely diagnosis&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> This classic variant of cutaneous FCL is characterized by a B-cell infiltrate with follicle center cells and a variable number of centroblasts that may be accompanied by abundant reactive T cells&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Pan B-cell markers and germinal center markers tend to be positive&#44; but the latter may be negative in FCL with a diffuse growth pattern&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Unlike in follicular lymphoma of nodal origin&#44; cells in Crosti lymphoma are normally not immunoreactive for bcl-2&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;6</span></a> Up to 15&#37; of primary cutaneous FCLs&#44; however&#44; express bcl-6 &#40;as was the case with our patient&#41;&#44; and this aids diagnosis&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Following the recommendations of the European Organisation for Research and Treatment of Cancer&#44;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> we initiated treatment with local radiation therapy&#46; This led to resolution of the lesions and there were no signs of recurrence after 8 months of follow-up&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">We have described a case diagnosed as Crosti lymphoma&#44; which is a classic variant of primary cutaneous FCL generally characterized by a diffuse growth pattern and abundant immunoreactive T cells&#44; although diagnosis can be complicated by an absence of germinal center markers&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;5</span></a> In our patient&#44; the main confounding factor was the large T-cell population as this made it difficult to interpret immunohistochemical results and observe tumor cells&#46; The diagnosis was established following a correlation of clinical and pathologic findings&#46;</p></span>"
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                      "titulo" => "European Organization for Research and Treatment of Cancer and International Society for Cutaneous Lymphoma consensus recommendations for the management of cutaneous B-cell lymphomas"
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                        0 => array:3 [
                          "colaboracion" => "European Organization for Research and Treatment of Cancer&#59; International Society for Cutaneous Lymphoma"
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                            0 => "N&#46;J&#46; Senff"
                            1 => "E&#46;M&#46; Noordijk"
                            2 => "Y&#46;H&#46; Kim"
                            3 => "M&#46; Bagot"
                            4 => "E&#46; Berti"
                            5 => "L&#46; Cerroni"
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                        "tituloSerie" => "Blood"
                        "fecha" => "2008"
                        "volumen" => "112"
                        "paginaInicial" => "1600"
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    "identificador" => "6157"
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    "en" => array:2 [
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  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219012002594?idApp=UINPBA000044"
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Article information
ISSN: 15782190
Original language: English
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Idiomas
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