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The first patient was a first-born twin girl delivered by caesarean section at 30 weeks&#8217; gestation due to maternal preeclampsia&#46; On the fifth day of life neutropenia with respiratory worsening was detected and antibiotic treatment with vancomycin and amikacin was started due to suspected sepsis&#46; On the eighth day 2 erythematous lesions appeared in the nasal area and on the right cheek&#46; After 24 hours they developed into necrotic ulcers with a base covered by whitish slough and abundant yellowish secretion&#46; Similar lesions were also seen on the hard palate and tongue &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Blood and samples from the lesions were taken for culture and topical gentamicin was added to the treatment because of suspected bacterial skin infection&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Two days later&#44; the patient showed clinical deterioration consistent with sepsis and the cultures were found to be positive for <span class="elsevierStyleItalic">P&#160;aeruginosa</span>&#46; Meropenem was added to the treatment regimen and the patient progressed favorably&#46; The skin lesions resolved&#44; leaving serious aesthetic sequelae with a loss of substance in the nasal septum and columella&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The second case involved a second-born female triplet delivered by caesarean section at 27 weeks&#8217; gestation&#46; On the second day of life neutropenia was detected&#44; requiring treatment with a colony-stimulating factor&#46; However&#44; on the next day the infant began to show signs of sepsis that coincided with the appearance of a nasal ulcer with whitish slough at the base and abundant yellowish exudate&#46; Based on the suspicion of EG and <span class="elsevierStyleItalic">P&#160;aeruginosa</span> sepsis&#44; meropenem and amikacin were administered&#46; Despite these measures&#44; the patient died at 4 days of life&#46; Cultures of blood and samples taken from the ulcer were positive for <span class="elsevierStyleItalic">P&#160;aeruginosa</span>&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The incidence of EG in patients with <span class="elsevierStyleItalic">P&#160;aeruginosa</span> bacteremia is between 1&#37; and 3&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a><span class="elsevierStyleItalic">P&#160;aeruginosa</span> causes up to 5&#46;7&#37; of nosocomial sepsis cases in premature newborns&#44; but few cases involving EG have been described&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">In the general population EG is most frequently located in the anogenital region&#44; on the extremities&#44; and on the trunk&#44; but rarely on the face or neck&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> By contrast&#44; most of the cases of preterm EG in the literature involve the face&#46; This characteristic formed the basis for the term <span class="elsevierStyleItalic">noma neonatorum</span>&#44; coined by Ghosal et al&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> because of the clinical similarity between this type of EG and noma &#40;cancrum oris&#41;&#44;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;7</span></a> a disease that is predominantly caused by <span class="elsevierStyleItalic">Fusobacterium necrophorum</span> and <span class="elsevierStyleItalic">Prevotella intermedia</span><a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;9</span></a> and described in children aged 2 years and older and adults living in unsanitary conditions&#46; Freeman et al&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> later included these cases of noma neonatorum in the description of EG because of their common etiologic pathogen&#44; <span class="elsevierStyleItalic">P&#160;aeruginosa</span>&#44; which is practically inexistent in classic noma&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The diagnosis of EG&#44; while mainly clinical&#44; must be confirmed by cultures taken from the lesions and&#44; in most cases&#44; a <span class="elsevierStyleItalic">P&#160;aeruginosa</span>&#8211;positive blood culture&#46; These analyses allow EG to be distinguished from other types of lesions in the differential diagnosis&#44; such as deep mycosis or lesions caused by anaerobic pathogens&#46; The main goal of treatment is to resolve the underlying bacteremia&#44; which affects prognosis&#44; and should include synergistic antibiotics generally consisting of an aminoglycoside and an antipseudomonal &#946;-lactam&#46; 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Cases and Research Letters
Facial Ecthyma Gangrenosum in 2 Preterm Neonates
Ectima gangrenoso facial en dos recién nacidos pretérmino
M.M. Serrano-Martína, J. del Bozb,
Corresponding author
mmarser@live.com

Corresponding author.
, M. Chaffanel-Peláeza, A. Vera-Casañoc
a Servicio de Neonatología, Hospital Regional Universitario Carlos Haya, Málaga, Spain
b Servicio de Dermatología, Hospital Costa del Sol, Marbella, Málaga, Spain
c Servicio de Dermatología, Hospital Regional Universitario Carlos Haya, Málaga, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Ecthyma gangrenosum &#40;EG&#41; is a bacterial skin infection generally caused by <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span>&#44; although it may also be caused by other organisms&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> It commonly appears in the context of <span class="elsevierStyleItalic">P&#160;aeruginosa</span> sepsis&#44; but the skin is occasionally the primary focus&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">EG usually appears in immunocompromised patients&#46; The characteristic clinical presentation is an erythematous macule that develops into a hemorrhagic vesicle and finally a necrotic ulcer&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">EG should be considered in the differential diagnosis of ulcerous skin lesions in preterm patients because a rapid diagnosis permits early treatment and thus reduces the high mortality associated with <span class="elsevierStyleItalic">P&#160;aeruginosa</span> sepsis&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">We report on 2 cases of EG in newborn infants&#46; The first patient was a first-born twin girl delivered by caesarean section at 30 weeks&#8217; gestation due to maternal preeclampsia&#46; On the fifth day of life neutropenia with respiratory worsening was detected and antibiotic treatment with vancomycin and amikacin was started due to suspected sepsis&#46; On the eighth day 2 erythematous lesions appeared in the nasal area and on the right cheek&#46; After 24 hours they developed into necrotic ulcers with a base covered by whitish slough and abundant yellowish secretion&#46; Similar lesions were also seen on the hard palate and tongue &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Blood and samples from the lesions were taken for culture and topical gentamicin was added to the treatment because of suspected bacterial skin infection&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Two days later&#44; the patient showed clinical deterioration consistent with sepsis and the cultures were found to be positive for <span class="elsevierStyleItalic">P&#160;aeruginosa</span>&#46; Meropenem was added to the treatment regimen and the patient progressed favorably&#46; The skin lesions resolved&#44; leaving serious aesthetic sequelae with a loss of substance in the nasal septum and columella&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The second case involved a second-born female triplet delivered by caesarean section at 27 weeks&#8217; gestation&#46; On the second day of life neutropenia was detected&#44; requiring treatment with a colony-stimulating factor&#46; However&#44; on the next day the infant began to show signs of sepsis that coincided with the appearance of a nasal ulcer with whitish slough at the base and abundant yellowish exudate&#46; Based on the suspicion of EG and <span class="elsevierStyleItalic">P&#160;aeruginosa</span> sepsis&#44; meropenem and amikacin were administered&#46; Despite these measures&#44; the patient died at 4 days of life&#46; Cultures of blood and samples taken from the ulcer were positive for <span class="elsevierStyleItalic">P&#160;aeruginosa</span>&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The incidence of EG in patients with <span class="elsevierStyleItalic">P&#160;aeruginosa</span> bacteremia is between 1&#37; and 3&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a><span class="elsevierStyleItalic">P&#160;aeruginosa</span> causes up to 5&#46;7&#37; of nosocomial sepsis cases in premature newborns&#44; but few cases involving EG have been described&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">In the general population EG is most frequently located in the anogenital region&#44; on the extremities&#44; and on the trunk&#44; but rarely on the face or neck&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> By contrast&#44; most of the cases of preterm EG in the literature involve the face&#46; This characteristic formed the basis for the term <span class="elsevierStyleItalic">noma neonatorum</span>&#44; coined by Ghosal et al&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> because of the clinical similarity between this type of EG and noma &#40;cancrum oris&#41;&#44;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;7</span></a> a disease that is predominantly caused by <span class="elsevierStyleItalic">Fusobacterium necrophorum</span> and <span class="elsevierStyleItalic">Prevotella intermedia</span><a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;9</span></a> and described in children aged 2 years and older and adults living in unsanitary conditions&#46; Freeman et al&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> later included these cases of noma neonatorum in the description of EG because of their common etiologic pathogen&#44; <span class="elsevierStyleItalic">P&#160;aeruginosa</span>&#44; which is practically inexistent in classic noma&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The diagnosis of EG&#44; while mainly clinical&#44; must be confirmed by cultures taken from the lesions and&#44; in most cases&#44; a <span class="elsevierStyleItalic">P&#160;aeruginosa</span>&#8211;positive blood culture&#46; These analyses allow EG to be distinguished from other types of lesions in the differential diagnosis&#44; such as deep mycosis or lesions caused by anaerobic pathogens&#46; The main goal of treatment is to resolve the underlying bacteremia&#44; which affects prognosis&#44; and should include synergistic antibiotics generally consisting of an aminoglycoside and an antipseudomonal &#946;-lactam&#46; The lesion should be treated with topical antibiotics and mechanical or chemical debridement&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">In conclusion&#44; EG must be included in the differential diagnosis of ulcerous lesions in preterm patients&#44; especially in cases with associated neutropenia&#44; bearing in mind the tendency for these lesions to appear on the face&#46; Rapid identification can allow for early and adequate antibiotic treatment and reduce the high mortality associated with <span class="elsevierStyleItalic">P&#160;aeruginosa</span> sepsis&#44; especially in lesions that appear days before clinical sepsis as described in the first of these 2 patients&#46;</p></span>"
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Article information
ISSN: 15782190
Original language: English
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