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cyclin D1<span class="elsevierStyleSup">&#8722;</span> and p53<span class="elsevierStyleSup">&#8722;</span> phenotype and a low proliferative index&#44; findings which were consistent with the diagnosis of FL&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">In March 2007&#44; the patient was referred to the dermatology department due to the gradual appearance of asymptomatic subcutaneous nodular lesions on the face&#44; chest and back&#46; The nodules had an erythematous-violacious appearance&#44; were slightly raised&#44; and had diameters ranging between 8<span class="elsevierStyleHsp" style=""></span>mm and 20<span class="elsevierStyleHsp" style=""></span>mm &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Biopsy of the lesions showed a lymphoid infiltrate composed of small monomorphous cells&#44; compatible with FL infiltration &#40;CD20<span class="elsevierStyleSup">&#43;</span>&#44; Bcl2<span class="elsevierStyleSup">&#43;</span>&#44; Bcl6<span class="elsevierStyleSup">&#43;</span>&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Reassessment of the disease at this time also demonstrated the development of lymphadenopathy&#44; for which chemotherapy was started with a rituximab-CHOP schedule &#40;cyclophosphamide&#44; vincristine&#44; adriamycin and prednisone&#41;&#46; Complete remission was achieved after 6 cycles&#44; with clearance of the subcutaneous nodules and the enlarged lymph nodes&#59; subsequently&#44; the patient was placed on maintenance therapy with rituximab administered every 3 months&#46; In December 2009&#44; the patient again presented with cutaneous lesions&#44; predominantly facial&#44; similar to those previously described&#59; biopsy reconfirmed the diagnosis of infiltration by FL&#46; The rituximab maintenance treatment ended in June 2010&#59; the skin lesions were still stable and there was no evidence of disease spread to other areas &#40;peripheral blood immunophenotyping and cervical-thoracic-abdomen CT scan were normal&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">FL is characterized by an indolent course and has no standardized treatment&#59; a variety of approaches are used&#44; including simple observation&#44; radiotherapy&#44; immunotherapy&#44; polychemotherapy&#44; maintenance treatment with rituximab&#44;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> and even the application of various hematopoietic stem cell transplantation treatment modalities&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">As in other lymphoid malignancies&#44; patients with FL can have extranodal involvement affecting the skin in up to 3&#46;8&#37; of cases&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Extranodal involvement in FL does not generally affect overall survival&#44; unlike the case with large diffuse B-cell lymphoma&#59; these 2 diseases constitute the majority of B-cell lymphomas in Spain&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> It is therefore important to rule out transformation of FL to more aggressive forms as these are associated with significantly decreased survival&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> For this reason&#44; lesions should be biopsied whenever a patient experiences relapse or disease progression&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Differential diagnosis is particularly important in primary cutaneous follicular center lymphoma&#44; since it shares histologic features with FL&#46; In addition to systemic involvement&#44; Bcl2 negativity&#44; which is common in cases primarily involving the skin&#44; may be of use in differentiating the 2 diseases&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">FL usually responds well to treatment&#44; although relapses are common and usually affect the lymph nodes&#44; bone marrow or peripheral blood&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> What is unusual is recurrence being limited to the skin&#44; as in our patient&#46; At present&#44; and after more than 6 years of follow-up&#44; the patient&#39;s disease remains limited to the skin&#46; The persistence of cutaneous disease reflects a lack of complete control of the disease&#44; and it is therefore likely that the patient will develop systemic disease in the future&#46;</p></span>"
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Case and Research Letters
Systemic Follicular Lymphoma With Cutaneous Manifestations and Exclusively Cutaneous Recurrence
Linfoma folicular sistémico con afectación cutánea y recidiva únicamente cutánea
A. Palacios Abufóna,
Corresponding author
andres.palacios.ib@gmail.com

Corresponding author.
, E. Acebo Mariñasa, J. Gardeazabal Garcíaa, J.C. García-Ruizb
a Servicio de Dermatología, Hospital Universitario de Cruces, Baracaldo, Vizcaya, Spain
b Servicio de Hematología, Hospital Universitario de Cruces, Baracaldo, Vizcaya, Spain
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Monoclonal B-cell lymphocytosis in the peripheral blood and bone marrow&#44; enlarged subcentimeter abdominal lymph nodes and splenomegaly were observed during the study&#46; The diagnosis was chronic B-cell lymphoproliferative syndrome and the patient was offered splenectomy&#44; which she refused at that time&#46; At follow-up in January 2007&#44; enlarged mediastinal and retroperitoneal lymph nodes &#40;&#8804;5<span class="elsevierStyleHsp" style=""></span>cm in diameter&#41; were observed&#44; prompting the performance of diagnostic and therapeutic splenectomy&#46; Histologic study of the spleen showed a proliferation of small lymphoid cells&#44; with a micronodular growth pattern&#44; predominantly in the germinal centers of the white pulp&#44; with infiltration of the red pulp&#46; The cells had a CD20<span class="elsevierStyleSup">&#43;</span>&#44; Bcl2<span class="elsevierStyleSup">&#43;</span>&#44; Bcl6<span class="elsevierStyleSup">&#43;</span>&#44; IgD<span class="elsevierStyleSup">&#8722;</span> CD23<span class="elsevierStyleSup">&#8722;</span>&#44; cyclin D1<span class="elsevierStyleSup">&#8722;</span> and p53<span class="elsevierStyleSup">&#8722;</span> phenotype and a low proliferative index&#44; findings which were consistent with the diagnosis of FL&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">In March 2007&#44; the patient was referred to the dermatology department due to the gradual appearance of asymptomatic subcutaneous nodular lesions on the face&#44; chest and back&#46; The nodules had an erythematous-violacious appearance&#44; were slightly raised&#44; and had diameters ranging between 8<span class="elsevierStyleHsp" style=""></span>mm and 20<span class="elsevierStyleHsp" style=""></span>mm &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Biopsy of the lesions showed a lymphoid infiltrate composed of small monomorphous cells&#44; compatible with FL infiltration &#40;CD20<span class="elsevierStyleSup">&#43;</span>&#44; Bcl2<span class="elsevierStyleSup">&#43;</span>&#44; Bcl6<span class="elsevierStyleSup">&#43;</span>&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Reassessment of the disease at this time also demonstrated the development of lymphadenopathy&#44; for which chemotherapy was started with a rituximab-CHOP schedule &#40;cyclophosphamide&#44; vincristine&#44; adriamycin and prednisone&#41;&#46; Complete remission was achieved after 6 cycles&#44; with clearance of the subcutaneous nodules and the enlarged lymph nodes&#59; subsequently&#44; the patient was placed on maintenance therapy with rituximab administered every 3 months&#46; In December 2009&#44; the patient again presented with cutaneous lesions&#44; predominantly facial&#44; similar to those previously described&#59; biopsy reconfirmed the diagnosis of infiltration by FL&#46; The rituximab maintenance treatment ended in June 2010&#59; the skin lesions were still stable and there was no evidence of disease spread to other areas &#40;peripheral blood immunophenotyping and cervical-thoracic-abdomen CT scan were normal&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">FL is characterized by an indolent course and has no standardized treatment&#59; a variety of approaches are used&#44; including simple observation&#44; radiotherapy&#44; immunotherapy&#44; polychemotherapy&#44; maintenance treatment with rituximab&#44;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> and even the application of various hematopoietic stem cell transplantation treatment modalities&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">As in other lymphoid malignancies&#44; patients with FL can have extranodal involvement affecting the skin in up to 3&#46;8&#37; of cases&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Extranodal involvement in FL does not generally affect overall survival&#44; unlike the case with large diffuse B-cell lymphoma&#59; these 2 diseases constitute the majority of B-cell lymphomas in Spain&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> It is therefore important to rule out transformation of FL to more aggressive forms as these are associated with significantly decreased survival&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> For this reason&#44; lesions should be biopsied whenever a patient experiences relapse or disease progression&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Differential diagnosis is particularly important in primary cutaneous follicular center lymphoma&#44; since it shares histologic features with FL&#46; In addition to systemic involvement&#44; Bcl2 negativity&#44; which is common in cases primarily involving the skin&#44; may be of use in differentiating the 2 diseases&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">FL usually responds well to treatment&#44; although relapses are common and usually affect the lymph nodes&#44; bone marrow or peripheral blood&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> What is unusual is recurrence being limited to the skin&#44; as in our patient&#46; At present&#44; and after more than 6 years of follow-up&#44; the patient&#39;s disease remains limited to the skin&#46; The persistence of cutaneous disease reflects a lack of complete control of the disease&#44; and it is therefore likely that the patient will develop systemic disease in the future&#46;</p></span>"
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Idiomas
Actas Dermo-Sifiliográficas
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¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?