array:24 [
  "pii" => "S1578219012000170"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2012.01.004"
  "estado" => "S300"
  "fechaPublicacion" => "2011-12-01"
  "aid" => "408"
  "copyright" => "Elsevier España, S.L. and AEDV"
  "copyrightAnyo" => "2010"
  "documento" => "simple-article"
  "crossmark" => 0
  "subdocumento" => "cor"
  "cita" => "Actas Dermosifiliogr. 2011;102:827-8"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 5718
    "formatos" => array:3 [
      "EPUB" => 57
      "HTML" => 4486
      "PDF" => 1175
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0001731011002250"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2011.01.015"
      "estado" => "S300"
      "fechaPublicacion" => "2011-12-01"
      "aid" => "408"
      "copyright" => "Elsevier España, S.L. y AEDV"
      "documento" => "simple-article"
      "crossmark" => 0
      "subdocumento" => "cor"
      "cita" => "Actas Dermosifiliogr. 2011;102:827-8"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 9003
        "formatos" => array:3 [
          "EPUB" => 4
          "HTML" => 6616
          "PDF" => 2383
        ]
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta cient&#237;fico-cl&#237;nica</span>"
        "titulo" => "Alopecia areata y terapias biol&#243;gicas&#46; Presentaci&#243;n de un caso asociado a adalimumab"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "827"
            "paginaFinal" => "828"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Alopecia Areata After Biologic Therapy&#58; Report of a Case Related to Adalimumab"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 600
                "Ancho" => 800
                "Tamanyo" => 142086
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Placa de alopecia areata en el v&#233;rtex un a&#241;o despu&#233;s de comenzar tratamiento con adalimumab&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "J&#46; Neila, A&#46; Carrizosa, C&#46; Ceballos, F&#46;M&#46; Camacho"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "J&#46;"
                "apellidos" => "Neila"
              ]
              1 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Carrizosa"
              ]
              2 => array:2 [
                "nombre" => "C&#46;"
                "apellidos" => "Ceballos"
              ]
              3 => array:2 [
                "nombre" => "F&#46;M&#46;"
                "apellidos" => "Camacho"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219012000170"
          "doi" => "10.1016/j.adengl.2012.01.004"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219012000170?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731011002250?idApp=UINPBA000044"
      "url" => "/00017310/0000010200000010/v1_201304241344/S0001731011002250/v1_201304241344/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1578219012000236"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2012.01.009"
    "estado" => "S300"
    "fechaPublicacion" => "2011-12-01"
    "aid" => "431"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2011;102:828-30"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 4420
      "formatos" => array:3 [
        "EPUB" => 51
        "HTML" => 3613
        "PDF" => 756
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and research letters</span>"
      "titulo" => "Episode of Pustular Psoriasis After a Tuberculin Test in a Patient With Plaque Psoriasis on Treatment With Etanercept"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "828"
          "paginaFinal" => "830"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Brote de psoriasis pustulosa despu&#233;s de la prueba de la tuberculina en un paciente con psoriasis en placas en tratamiento con etanercept"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1182
              "Ancho" => 1580
              "Tamanyo" => 248714
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Pustules on the residual psoriasis plaques&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "R&#46;M&#46; Guinovart, C&#46; Ferr&#225;ndiz, I&#46; Bielsa, J&#46;M&#46; Carrascosa"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "R&#46;M&#46;"
              "apellidos" => "Guinovart"
            ]
            1 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Ferr&#225;ndiz"
            ]
            2 => array:2 [
              "nombre" => "I&#46;"
              "apellidos" => "Bielsa"
            ]
            3 => array:2 [
              "nombre" => "J&#46;M&#46;"
              "apellidos" => "Carrascosa"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731011002882"
        "doi" => "10.1016/j.ad.2011.04.012"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731011002882?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219012000236?idApp=UINPBA000044"
    "url" => "/15782190/0000010200000010/v1_201304241244/S1578219012000236/v1_201304241244/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1578219012000169"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2012.01.003"
    "estado" => "S300"
    "fechaPublicacion" => "2011-12-01"
    "aid" => "406"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2011;102:825-7"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 5039
      "formatos" => array:3 [
        "EPUB" => 50
        "HTML" => 4132
        "PDF" => 857
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and research letters</span>"
      "titulo" => "Leukocytoclastic Vasculitis Related to Cocaine Use"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "825"
          "paginaFinal" => "827"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Vasculitis leucocitocl&#225;stica asociada a consumo de coca&#237;na"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 876
              "Ancho" => 951
              "Tamanyo" => 282714
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Histopathology&#58; mainly neutrophilic&#44; abundant perivascular inflammatory infiltrate that infiltrates and partially destroys blood vessel walls&#59; prominent leukocytoclasis and multiple foci of vascular thrombosis &#40;periodic acid-Schiff&#44; original magnification x40&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Y&#46; Salas-Esp&#237;ndola, A&#46; Peniche-Castellanos, I&#46; L&#243;pez-Gehrke, P&#46; Mercadillo-P&#233;rez"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "Y&#46;"
              "apellidos" => "Salas-Esp&#237;ndola"
            ]
            1 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Peniche-Castellanos"
            ]
            2 => array:2 [
              "nombre" => "I&#46;"
              "apellidos" => "L&#243;pez-Gehrke"
            ]
            3 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Mercadillo-P&#233;rez"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731011002237"
        "doi" => "10.1016/j.ad.2011.01.014"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731011002237?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219012000169?idApp=UINPBA000044"
    "url" => "/15782190/0000010200000010/v1_201304241244/S1578219012000169/v1_201304241244/en/main.assets"
  ]
  "en" => array:15 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case and research letters</span>"
    "titulo" => "Alopecia Areata After Biologic Therapy&#58; Report of a Case Related to Adalimumab"
    "tieneTextoCompleto" => true
    "saludo" => "<span class="elsevierStyleItalic">To the Editor&#58;</span>"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "827"
        "paginaFinal" => "828"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "J&#46; Neila, A&#46; Carrizosa, C&#46; Ceballos, F&#46;M&#46; Camacho"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "J&#46;"
            "apellidos" => "Neila"
            "email" => array:1 [
              0 => "drneils&#64;hotmail&#46;com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "A&#46;"
            "apellidos" => "Carrizosa"
          ]
          2 => array:2 [
            "nombre" => "C&#46;"
            "apellidos" => "Ceballos"
          ]
          3 => array:2 [
            "nombre" => "F&#46;M&#46;"
            "apellidos" => "Camacho"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:1 [
            "entidad" => "Departamento de Dermatolog&#237;a M&#233;dico Quir&#250;rgica&#44; Hospital Universitario Virgen Macarena&#44; Sevilla&#44; Spain"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Alopecia areata y terapias biol&#243;gicas&#46; Presentaci&#243;n de un caso asociado a adalimumab"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1173
            "Ancho" => 1583
            "Tamanyo" => 238113
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Alopecia areata plaque located on the cranial vertex after a year of adalimumab treatment&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Alopecia areata &#40;AA&#41; is an autoimmune disorder causing nonscarring hair loss&#46; It is an organ-specific response at the cellular level and is mediated by CD4<span class="elsevierStyleSup">&#43;</span> and CD8<span class="elsevierStyleSup">&#43;</span> T cells&#46; These lymphocytes may be activated by autoantigens at the hair root&#44; inducing inflammation that eventually leads to hair loss&#46; The increased use of biologic therapies has recently led to a growing number of publications discussing the possible link between these treatments and autoimmune disorders&#44; including AA&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">A 39-year-old man with plaque psoriasis on a regimen of adalimumab &#40;40<span class="elsevierStyleHsp" style=""></span>mg&#41; twice weekly presented with 2 alopecia plaques after 1 year of treatment&#46; The plaques&#44; located on the cranial vertex&#44; had appeared over the previous few weeks &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The patient had no family or personal history of AA and reported no events involving infection&#44; vaccination&#44; or stress prior to the loss of hair&#46; AA was diagnosed&#44; adalimumab treatment was stopped&#44; and a daily application of clobetasol propionate 0&#46;05&#37; cream was prescribed&#46; After 6 months the diameter of both alopecia plaques had not changed despite the withdrawal of adalimumab&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Adalimumab is a recombinant and fully humanized monoclonal antibody that works against tumor necrosis factor &#945; &#40;TNF-&#945;&#41; and has been approved for the treatment of rheumatoid arthritis&#44; ankylosing spondylitis&#44; Crohn disease&#44; psoriasis&#44; and psoriatic arthritis&#46; TNF-&#945; is a proinflammatory cytokine in the body&#39;s immune system&#44; but when it is neutralized by anti-TNF-&#945; antibodies like adalimumab&#44; autoimmune disorders such as systematic sclerosis and systemic lupus erythematosus have been known to develop&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The role of TNF-&#945; in the physiopathology of these processes is complex&#44; but the cytokine has been shown to originate in the mononuclear cells that surround the hair follicle in AA<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> and inhibit hair follicle growth during in vitro testing&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> TNF-&#945; is thus linked to hair loss&#46; Accordingly&#44; anti-TNF-&#945; medications and other biologic therapies have been used to treat AA&#44; but with poor results&#59; in some sporadic cases satisfactory responses have been reported&#44; but no large study has demonstrated any significant therapeutic effects of etanercept&#44;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> alefacept&#44;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> or efalizumab&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">At the same time&#44; new cases of AA have become more frequent in patients undergoing treatment with anti-TNF-&#945; and other biologic therapies&#46; Cases of AA induced by etanercept&#44; infliximab&#44; and adalimumab are being reported&#46; Garc&#237;a Bartels et al<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> were the first to describe adalimumab-induced AA&#59; the patient was a 23-year-old woman who developed AA universalis 2 months after starting treatment&#46; Seven patients have since been described&#59; only 2 had a past history of AA and 3 developed the universalis form&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;6&#8211;10</span></a> The amount of time from starting treatment with anti-TNF-&#945; to the appearance of AA ranged between 2 months and 2 years&#46; In cases in which adalimumab was withdrawn&#44; no new hair growth occurred in any of the patients studied&#46; Similarly&#44; hair did not regrow on our patient&#39;s plaques&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The mechanism by which TNF-&#945; inhibition induces AA is unknown&#46; In 2005&#44; De Bandt et al<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> hypothesized&#44; on the basis of 22 cases of anti-TNF-&#945;-induced systemic lupus erythematosus in France&#44; that TNF-&#945; initiates the spread of suppressed CD4<span class="elsevierStyleSup">&#43;</span> regulatory T lymphocytes that are responsible for maintaining immunological tolerance and preventing autoimmunity&#46; Thus&#44; both AA and other autoimmune processes induced by anti-TNF-&#945; may develop through the inhibition of regulatory T cells&#46; However&#44; whereas all patients with lupus went into remission after the withdrawal of anti-TNF-&#945;&#44; patients with AA do not usually respond&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">In this new case of AA associated with adalimumab treatment&#44; the possibility of coincidence cannot be ruled out&#59; however&#44; earlier reports of AA in patients treated with adalimumab and the implication of anti-TNF-&#945; medications in inducing other autoimmune disorders suggests an association between hair loss and the use of this TNF inhibitor&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara">Please cite this article as&#58; Neila J&#44; et al&#46; Alopecia areata y terapias biol&#243;gicas&#46; Presentaci&#243;n de un caso asociado a adalimumab&#46; Actas Dermosifiliograf&#46;2011&#59;102&#58;827-828&#46;</p>"
      ]
    ]
    "multimedia" => array:1 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1173
            "Ancho" => 1583
            "Tamanyo" => 238113
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Alopecia areata plaque located on the cranial vertex after a year of adalimumab treatment&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:11 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alopecia areata universalis elicited during treatment with adalimumab"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "N&#46; Pelivani"
                            1 => "A&#46;S&#46; Hassan"
                            2 => "L&#46;R&#46; Braathen"
                            3 => "R&#46;E&#46; Hunger"
                            4 => "N&#46; Yawalkar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000113945"
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatology"
                        "fecha" => "2008"
                        "volumen" => "216"
                        "paginaInicial" => "320"
                        "paginaFinal" => "323"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18230980"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of interleukins&#44; colony-stimulating factor and tumour necrosis factor on human hair follicle growth in vitro&#58; a possible role for interleukin-1 and tumour necrosis factor-alpha in alopecia areata"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46;P&#46; Philpott"
                            1 => "D&#46;A&#46; Sanders"
                            2 => "J&#46; Bowen"
                            3 => "T&#46; Kealey"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "1996"
                        "volumen" => "135"
                        "paginaInicial" => "942"
                        "paginaFinal" => "948"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8977716"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Etanercept does not effectively treat moderate to severe alopecia areata&#58; an open label study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "B&#46;E&#46; Strober"
                            1 => "K&#46; Siu"
                            2 => "A&#46;F&#46; Alexis"
                            3 => "G&#46; Kim"
                            4 => "K&#46; Washenik"
                            5 => "A&#46; Sinha"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2005.03.039"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2005"
                        "volumen" => "52"
                        "paginaInicial" => "1082"
                        "paginaFinal" => "1084"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15928633"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alefacept for severe alopecia areata&#58; a randomized&#44; double-blind&#44; placebo-controlled study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "B&#46;E&#46; Strober"
                            1 => "K&#46; Menon"
                            2 => "A&#46; McMichael"
                            3 => "M&#46; Hordinsky"
                            4 => "G&#46; Krueger"
                            5 => "J&#46; Panko"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/archdermatol.2009.264"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "2009"
                        "volumen" => "145"
                        "paginaInicial" => "1262"
                        "paginaFinal" => "1266"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19917955"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Subcutaneous efalizumab is not effective in the treatment of alopecia areata"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "V&#46;H&#46; Price"
                            1 => "M&#46;K&#46; Hordinsky"
                            2 => "E&#46;A&#46; Olsen"
                            3 => "J&#46;L&#46; Roberts"
                            4 => "E&#46;C&#46; Siegfried"
                            5 => "E&#46;S&#46; Rafal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2007.10.645"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2008"
                        "volumen" => "58"
                        "paginaInicial" => "395"
                        "paginaFinal" => "402"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18280336"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Development of alopecia areata universalis in a patient receiving adalimumab"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "N&#46; Garc&#237;a Bartels"
                            1 => "H&#46;H&#46; Lee"
                            2 => "M&#46; Worm"
                            3 => "G&#46;R&#46; Burmester"
                            4 => "W&#46; Sterry"
                            5 => "U&#46; Blume-Peytavi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/archderm.142.12.1654"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "2006"
                        "volumen" => "142"
                        "paginaInicial" => "1654"
                        "paginaFinal" => "1655"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17179003"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Biologic agents and alopecia areata"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;C&#46; Katoulis"
                            1 => "A&#46; Alevizou"
                            2 => "E&#46; Bozi"
                            3 => "S&#46; Georgala"
                            4 => "M&#46; Mistidou"
                            5 => "D&#46; Kalogeromitros"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000174826"
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatology"
                        "fecha" => "2009"
                        "volumen" => "218"
                        "paginaInicial" => "184"
                        "paginaFinal" => "185"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19018127"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alopecia areata universalis during treatment of rheumatoid arthritis with anti-TNF-alpha antibody &#40;adalimumab&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "Y&#46; Chaves"
                            1 => "G&#46; Duarte"
                            2 => "B&#46; Ben-Said"
                            3 => "J&#46; Tebib"
                            4 => "F&#46; Berard"
                            5 => "J&#46;F&#46; Nicolas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000162180"
                      "Revista" => array:5 [
                        "tituloSerie" => "Dermatology"
                        "fecha" => "2008"
                        "volumen" => "217"
                        "paginaInicial" => "380"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18849606"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alopecia areata following adalimumab"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "C&#46; Kirshen"
                            1 => "N&#46; Kanigsberg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Cutan Med Surg"
                        "fecha" => "2009"
                        "volumen" => "13"
                        "paginaInicial" => "48"
                        "paginaFinal" => "50"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19298772"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alopecia areata as another immune-mediated disease developed in patients treated with tumour necrosis factor-alpha blocker agents"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; Ferran"
                            1 => "J&#46; Calvet"
                            2 => "M&#46; Almirall"
                            3 => "R&#46;M&#46; Pujol"
                            4 => "J&#46; Maym&#243;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1468-3083.2010.03770.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Eur Acad Dermatol Venereol"
                        "fecha" => "2010"
                        "volumen" => "25"
                        "paginaInicial" => "479"
                        "paginaFinal" => "484"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20586836"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sistemic lupus erythematosus induced by anti-tumour necrosis factor alpha therapy&#58; a French national survey"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; De Bandt"
                            1 => "J&#46; Sibilia"
                            2 => "X&#46; Le Lo&#235;t"
                            3 => "S&#46; Prouzeau"
                            4 => "B&#46; Fautrel"
                            5 => "C&#46; Marcelli"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arthritis Res Ther"
                        "fecha" => "2005"
                        "volumen" => "7"
                        "paginaInicial" => "545"
                        "paginaFinal" => "551"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010200000010/v1_201304241244/S1578219012000170/v1_201304241244/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6157"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case and Research Letters"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010200000010/v1_201304241244/S1578219012000170/v1_201304241244/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219012000170?idApp=UINPBA000044"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Case and research letters
Alopecia Areata After Biologic Therapy: Report of a Case Related to Adalimumab
Alopecia areata y terapias biológicas. Presentación de un caso asociado a adalimumab
J. Neila
Corresponding author
drneils@hotmail.com

Corresponding author.
, A. Carrizosa, C. Ceballos, F.M. Camacho
Departamento de Dermatología Médico Quirúrgica, Hospital Universitario Virgen Macarena, Sevilla, Spain
Read
14339
Times
was read the article
3318
Total PDF
11021
Total HTML
Share statistics
 array:24 [
  "pii" => "S1578219012000170"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2012.01.004"
  "estado" => "S300"
  "fechaPublicacion" => "2011-12-01"
  "aid" => "408"
  "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
  "copyrightAnyo" => "2010"
  "documento" => "simple-article"
  "crossmark" => 0
  "subdocumento" => "cor"
  "cita" => "Actas Dermosifiliogr. 2011;102:827-8"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 5718
    "formatos" => array:3 [
      "EPUB" => 57
      "HTML" => 4486
      "PDF" => 1175
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0001731011002250"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2011.01.015"
      "estado" => "S300"
      "fechaPublicacion" => "2011-12-01"
      "aid" => "408"
      "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; y AEDV"
      "documento" => "simple-article"
      "crossmark" => 0
      "subdocumento" => "cor"
      "cita" => "Actas Dermosifiliogr. 2011;102:827-8"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 9003
        "formatos" => array:3 [
          "EPUB" => 4
          "HTML" => 6616
          "PDF" => 2383
        ]
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta cient&#237;fico-cl&#237;nica</span>"
        "titulo" => "Alopecia areata y terapias biol&#243;gicas&#46; Presentaci&#243;n de un caso asociado a adalimumab"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "827"
            "paginaFinal" => "828"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Alopecia Areata After Biologic Therapy&#58; Report of a Case Related to Adalimumab"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 600
                "Ancho" => 800
                "Tamanyo" => 142086
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Placa de alopecia areata en el v&#233;rtex un a&#241;o despu&#233;s de comenzar tratamiento con adalimumab&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "J&#46; Neila, A&#46; Carrizosa, C&#46; Ceballos, F&#46;M&#46; Camacho"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "J&#46;"
                "apellidos" => "Neila"
              ]
              1 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Carrizosa"
              ]
              2 => array:2 [
                "nombre" => "C&#46;"
                "apellidos" => "Ceballos"
              ]
              3 => array:2 [
                "nombre" => "F&#46;M&#46;"
                "apellidos" => "Camacho"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219012000170"
          "doi" => "10.1016/j.adengl.2012.01.004"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219012000170?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731011002250?idApp=UINPBA000044"
      "url" => "/00017310/0000010200000010/v1_201304241344/S0001731011002250/v1_201304241344/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1578219012000236"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2012.01.009"
    "estado" => "S300"
    "fechaPublicacion" => "2011-12-01"
    "aid" => "431"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2011;102:828-30"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 4420
      "formatos" => array:3 [
        "EPUB" => 51
        "HTML" => 3613
        "PDF" => 756
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and research letters</span>"
      "titulo" => "Episode of Pustular Psoriasis After a Tuberculin Test in a Patient With Plaque Psoriasis on Treatment With Etanercept"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "828"
          "paginaFinal" => "830"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Brote de psoriasis pustulosa despu&#233;s de la prueba de la tuberculina en un paciente con psoriasis en placas en tratamiento con etanercept"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1182
              "Ancho" => 1580
              "Tamanyo" => 248714
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Pustules on the residual psoriasis plaques&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "R&#46;M&#46; Guinovart, C&#46; Ferr&#225;ndiz, I&#46; Bielsa, J&#46;M&#46; Carrascosa"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "R&#46;M&#46;"
              "apellidos" => "Guinovart"
            ]
            1 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Ferr&#225;ndiz"
            ]
            2 => array:2 [
              "nombre" => "I&#46;"
              "apellidos" => "Bielsa"
            ]
            3 => array:2 [
              "nombre" => "J&#46;M&#46;"
              "apellidos" => "Carrascosa"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731011002882"
        "doi" => "10.1016/j.ad.2011.04.012"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731011002882?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219012000236?idApp=UINPBA000044"
    "url" => "/15782190/0000010200000010/v1_201304241244/S1578219012000236/v1_201304241244/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1578219012000169"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2012.01.003"
    "estado" => "S300"
    "fechaPublicacion" => "2011-12-01"
    "aid" => "406"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2011;102:825-7"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 5039
      "formatos" => array:3 [
        "EPUB" => 50
        "HTML" => 4132
        "PDF" => 857
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and research letters</span>"
      "titulo" => "Leukocytoclastic Vasculitis Related to Cocaine Use"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "825"
          "paginaFinal" => "827"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Vasculitis leucocitocl&#225;stica asociada a consumo de coca&#237;na"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 876
              "Ancho" => 951
              "Tamanyo" => 282714
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Histopathology&#58; mainly neutrophilic&#44; abundant perivascular inflammatory infiltrate that infiltrates and partially destroys blood vessel walls&#59; prominent leukocytoclasis and multiple foci of vascular thrombosis &#40;periodic acid-Schiff&#44; original magnification x40&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Y&#46; Salas-Esp&#237;ndola, A&#46; Peniche-Castellanos, I&#46; L&#243;pez-Gehrke, P&#46; Mercadillo-P&#233;rez"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "Y&#46;"
              "apellidos" => "Salas-Esp&#237;ndola"
            ]
            1 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Peniche-Castellanos"
            ]
            2 => array:2 [
              "nombre" => "I&#46;"
              "apellidos" => "L&#243;pez-Gehrke"
            ]
            3 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Mercadillo-P&#233;rez"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731011002237"
        "doi" => "10.1016/j.ad.2011.01.014"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731011002237?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219012000169?idApp=UINPBA000044"
    "url" => "/15782190/0000010200000010/v1_201304241244/S1578219012000169/v1_201304241244/en/main.assets"
  ]
  "en" => array:15 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case and research letters</span>"
    "titulo" => "Alopecia Areata After Biologic Therapy&#58; Report of a Case Related to Adalimumab"
    "tieneTextoCompleto" => true
    "saludo" => "<span class="elsevierStyleItalic">To the Editor&#58;</span>"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "827"
        "paginaFinal" => "828"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "J&#46; Neila, A&#46; Carrizosa, C&#46; Ceballos, F&#46;M&#46; Camacho"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "J&#46;"
            "apellidos" => "Neila"
            "email" => array:1 [
              0 => "drneils&#64;hotmail&#46;com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "A&#46;"
            "apellidos" => "Carrizosa"
          ]
          2 => array:2 [
            "nombre" => "C&#46;"
            "apellidos" => "Ceballos"
          ]
          3 => array:2 [
            "nombre" => "F&#46;M&#46;"
            "apellidos" => "Camacho"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:1 [
            "entidad" => "Departamento de Dermatolog&#237;a M&#233;dico Quir&#250;rgica&#44; Hospital Universitario Virgen Macarena&#44; Sevilla&#44; Spain"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Alopecia areata y terapias biol&#243;gicas&#46; Presentaci&#243;n de un caso asociado a adalimumab"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1173
            "Ancho" => 1583
            "Tamanyo" => 238113
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Alopecia areata plaque located on the cranial vertex after a year of adalimumab treatment&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Alopecia areata &#40;AA&#41; is an autoimmune disorder causing nonscarring hair loss&#46; It is an organ-specific response at the cellular level and is mediated by CD4<span class="elsevierStyleSup">&#43;</span> and CD8<span class="elsevierStyleSup">&#43;</span> T cells&#46; These lymphocytes may be activated by autoantigens at the hair root&#44; inducing inflammation that eventually leads to hair loss&#46; The increased use of biologic therapies has recently led to a growing number of publications discussing the possible link between these treatments and autoimmune disorders&#44; including AA&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">A 39-year-old man with plaque psoriasis on a regimen of adalimumab &#40;40<span class="elsevierStyleHsp" style=""></span>mg&#41; twice weekly presented with 2 alopecia plaques after 1 year of treatment&#46; The plaques&#44; located on the cranial vertex&#44; had appeared over the previous few weeks &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The patient had no family or personal history of AA and reported no events involving infection&#44; vaccination&#44; or stress prior to the loss of hair&#46; AA was diagnosed&#44; adalimumab treatment was stopped&#44; and a daily application of clobetasol propionate 0&#46;05&#37; cream was prescribed&#46; After 6 months the diameter of both alopecia plaques had not changed despite the withdrawal of adalimumab&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Adalimumab is a recombinant and fully humanized monoclonal antibody that works against tumor necrosis factor &#945; &#40;TNF-&#945;&#41; and has been approved for the treatment of rheumatoid arthritis&#44; ankylosing spondylitis&#44; Crohn disease&#44; psoriasis&#44; and psoriatic arthritis&#46; TNF-&#945; is a proinflammatory cytokine in the body&#39;s immune system&#44; but when it is neutralized by anti-TNF-&#945; antibodies like adalimumab&#44; autoimmune disorders such as systematic sclerosis and systemic lupus erythematosus have been known to develop&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The role of TNF-&#945; in the physiopathology of these processes is complex&#44; but the cytokine has been shown to originate in the mononuclear cells that surround the hair follicle in AA<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> and inhibit hair follicle growth during in vitro testing&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> TNF-&#945; is thus linked to hair loss&#46; Accordingly&#44; anti-TNF-&#945; medications and other biologic therapies have been used to treat AA&#44; but with poor results&#59; in some sporadic cases satisfactory responses have been reported&#44; but no large study has demonstrated any significant therapeutic effects of etanercept&#44;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> alefacept&#44;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> or efalizumab&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">At the same time&#44; new cases of AA have become more frequent in patients undergoing treatment with anti-TNF-&#945; and other biologic therapies&#46; Cases of AA induced by etanercept&#44; infliximab&#44; and adalimumab are being reported&#46; Garc&#237;a Bartels et al<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> were the first to describe adalimumab-induced AA&#59; the patient was a 23-year-old woman who developed AA universalis 2 months after starting treatment&#46; Seven patients have since been described&#59; only 2 had a past history of AA and 3 developed the universalis form&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;6&#8211;10</span></a> The amount of time from starting treatment with anti-TNF-&#945; to the appearance of AA ranged between 2 months and 2 years&#46; In cases in which adalimumab was withdrawn&#44; no new hair growth occurred in any of the patients studied&#46; Similarly&#44; hair did not regrow on our patient&#39;s plaques&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The mechanism by which TNF-&#945; inhibition induces AA is unknown&#46; In 2005&#44; De Bandt et al<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> hypothesized&#44; on the basis of 22 cases of anti-TNF-&#945;-induced systemic lupus erythematosus in France&#44; that TNF-&#945; initiates the spread of suppressed CD4<span class="elsevierStyleSup">&#43;</span> regulatory T lymphocytes that are responsible for maintaining immunological tolerance and preventing autoimmunity&#46; Thus&#44; both AA and other autoimmune processes induced by anti-TNF-&#945; may develop through the inhibition of regulatory T cells&#46; However&#44; whereas all patients with lupus went into remission after the withdrawal of anti-TNF-&#945;&#44; patients with AA do not usually respond&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">In this new case of AA associated with adalimumab treatment&#44; the possibility of coincidence cannot be ruled out&#59; however&#44; earlier reports of AA in patients treated with adalimumab and the implication of anti-TNF-&#945; medications in inducing other autoimmune disorders suggests an association between hair loss and the use of this TNF inhibitor&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara">Please cite this article as&#58; Neila J&#44; et al&#46; Alopecia areata y terapias biol&#243;gicas&#46; Presentaci&#243;n de un caso asociado a adalimumab&#46; Actas Dermosifiliograf&#46;2011&#59;102&#58;827-828&#46;</p>"
      ]
    ]
    "multimedia" => array:1 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1173
            "Ancho" => 1583
            "Tamanyo" => 238113
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Alopecia areata plaque located on the cranial vertex after a year of adalimumab treatment&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:11 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alopecia areata universalis elicited during treatment with adalimumab"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "N&#46; Pelivani"
                            1 => "A&#46;S&#46; Hassan"
                            2 => "L&#46;R&#46; Braathen"
                            3 => "R&#46;E&#46; Hunger"
                            4 => "N&#46; Yawalkar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000113945"
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatology"
                        "fecha" => "2008"
                        "volumen" => "216"
                        "paginaInicial" => "320"
                        "paginaFinal" => "323"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18230980"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of interleukins&#44; colony-stimulating factor and tumour necrosis factor on human hair follicle growth in vitro&#58; a possible role for interleukin-1 and tumour necrosis factor-alpha in alopecia areata"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46;P&#46; Philpott"
                            1 => "D&#46;A&#46; Sanders"
                            2 => "J&#46; Bowen"
                            3 => "T&#46; Kealey"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "1996"
                        "volumen" => "135"
                        "paginaInicial" => "942"
                        "paginaFinal" => "948"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8977716"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Etanercept does not effectively treat moderate to severe alopecia areata&#58; an open label study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "B&#46;E&#46; Strober"
                            1 => "K&#46; Siu"
                            2 => "A&#46;F&#46; Alexis"
                            3 => "G&#46; Kim"
                            4 => "K&#46; Washenik"
                            5 => "A&#46; Sinha"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2005.03.039"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2005"
                        "volumen" => "52"
                        "paginaInicial" => "1082"
                        "paginaFinal" => "1084"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15928633"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alefacept for severe alopecia areata&#58; a randomized&#44; double-blind&#44; placebo-controlled study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "B&#46;E&#46; Strober"
                            1 => "K&#46; Menon"
                            2 => "A&#46; McMichael"
                            3 => "M&#46; Hordinsky"
                            4 => "G&#46; Krueger"
                            5 => "J&#46; Panko"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/archdermatol.2009.264"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "2009"
                        "volumen" => "145"
                        "paginaInicial" => "1262"
                        "paginaFinal" => "1266"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19917955"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Subcutaneous efalizumab is not effective in the treatment of alopecia areata"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "V&#46;H&#46; Price"
                            1 => "M&#46;K&#46; Hordinsky"
                            2 => "E&#46;A&#46; Olsen"
                            3 => "J&#46;L&#46; Roberts"
                            4 => "E&#46;C&#46; Siegfried"
                            5 => "E&#46;S&#46; Rafal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2007.10.645"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2008"
                        "volumen" => "58"
                        "paginaInicial" => "395"
                        "paginaFinal" => "402"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18280336"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Development of alopecia areata universalis in a patient receiving adalimumab"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "N&#46; Garc&#237;a Bartels"
                            1 => "H&#46;H&#46; Lee"
                            2 => "M&#46; Worm"
                            3 => "G&#46;R&#46; Burmester"
                            4 => "W&#46; Sterry"
                            5 => "U&#46; Blume-Peytavi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/archderm.142.12.1654"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "2006"
                        "volumen" => "142"
                        "paginaInicial" => "1654"
                        "paginaFinal" => "1655"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17179003"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Biologic agents and alopecia areata"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;C&#46; Katoulis"
                            1 => "A&#46; Alevizou"
                            2 => "E&#46; Bozi"
                            3 => "S&#46; Georgala"
                            4 => "M&#46; Mistidou"
                            5 => "D&#46; Kalogeromitros"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000174826"
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatology"
                        "fecha" => "2009"
                        "volumen" => "218"
                        "paginaInicial" => "184"
                        "paginaFinal" => "185"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19018127"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alopecia areata universalis during treatment of rheumatoid arthritis with anti-TNF-alpha antibody &#40;adalimumab&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "Y&#46; Chaves"
                            1 => "G&#46; Duarte"
                            2 => "B&#46; Ben-Said"
                            3 => "J&#46; Tebib"
                            4 => "F&#46; Berard"
                            5 => "J&#46;F&#46; Nicolas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000162180"
                      "Revista" => array:5 [
                        "tituloSerie" => "Dermatology"
                        "fecha" => "2008"
                        "volumen" => "217"
                        "paginaInicial" => "380"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18849606"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alopecia areata following adalimumab"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "C&#46; Kirshen"
                            1 => "N&#46; Kanigsberg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Cutan Med Surg"
                        "fecha" => "2009"
                        "volumen" => "13"
                        "paginaInicial" => "48"
                        "paginaFinal" => "50"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19298772"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alopecia areata as another immune-mediated disease developed in patients treated with tumour necrosis factor-alpha blocker agents"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; Ferran"
                            1 => "J&#46; Calvet"
                            2 => "M&#46; Almirall"
                            3 => "R&#46;M&#46; Pujol"
                            4 => "J&#46; Maym&#243;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1468-3083.2010.03770.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Eur Acad Dermatol Venereol"
                        "fecha" => "2010"
                        "volumen" => "25"
                        "paginaInicial" => "479"
                        "paginaFinal" => "484"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20586836"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sistemic lupus erythematosus induced by anti-tumour necrosis factor alpha therapy&#58; a French national survey"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; De Bandt"
                            1 => "J&#46; Sibilia"
                            2 => "X&#46; Le Lo&#235;t"
                            3 => "S&#46; Prouzeau"
                            4 => "B&#46; Fautrel"
                            5 => "C&#46; Marcelli"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arthritis Res Ther"
                        "fecha" => "2005"
                        "volumen" => "7"
                        "paginaInicial" => "545"
                        "paginaFinal" => "551"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010200000010/v1_201304241244/S1578219012000170/v1_201304241244/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6157"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case and Research Letters"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010200000010/v1_201304241244/S1578219012000170/v1_201304241244/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219012000170?idApp=UINPBA000044"
]
Article information
ISSN: 15782190
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 26 7 33
2024 October 190 42 232
2024 September 205 31 236
2024 August 214 62 276
2024 July 222 39 261
2024 June 176 37 213
2024 May 182 47 229
2024 April 164 34 198
2024 March 192 49 241
2024 February 175 46 221
2024 January 184 36 220
2023 December 166 26 192
2023 November 170 46 216
2023 October 169 42 211
2023 September 134 37 171
2023 August 122 28 150
2023 July 145 40 185
2023 June 120 36 156
2023 May 95 40 135
2023 April 89 34 123
2023 March 60 33 93
2023 February 76 26 102
2023 January 94 38 132
2022 December 98 39 137
2022 November 32 40 72
2022 October 44 19 63
2022 September 39 25 64
2022 August 48 46 94
2022 July 47 31 78
2022 June 41 27 68
2022 May 101 42 143
2022 April 167 45 212
2022 March 175 48 223
2022 February 102 40 142
2022 January 120 48 168
2021 December 139 52 191
2021 November 144 43 187
2021 October 131 50 181
2021 September 115 46 161
2021 August 109 44 153
2021 July 89 33 122
2021 June 107 45 152
2021 May 95 55 150
2021 April 212 81 293
2021 March 134 41 175
2021 February 151 46 197
2021 January 118 30 148
2020 December 90 28 118
2020 November 76 32 108
2020 October 74 17 91
2020 September 64 18 82
2020 August 55 27 82
2020 July 63 30 93
2020 June 62 27 89
2020 May 37 38 75
2020 April 47 26 73
2020 March 36 25 61
2020 February 4 6 10
2020 January 6 12 18
2019 December 8 5 13
2019 November 3 8 11
2019 October 0 11 11
2019 September 8 13 21
2019 August 5 9 14
2019 July 4 15 19
2019 June 4 10 14
2019 May 8 12 20
2019 April 2 12 14
2019 March 2 17 19
2019 February 2 5 7
2019 January 2 3 5
2018 December 2 16 18
2018 November 3 3 6
2018 October 3 0 3
2018 September 0 5 5
2018 August 0 15 15
2018 July 0 23 23
2018 June 0 4 4
2018 May 0 11 11
2018 April 0 5 5
2018 March 1 7 8
2018 February 133 7 140
2018 January 151 12 163
2017 December 168 12 180
2017 November 100 10 110
2017 October 59 17 76
2017 September 78 16 94
2017 August 103 12 115
2017 July 107 16 123
2017 June 144 25 169
2017 May 130 16 146
2017 April 140 24 164
2017 March 151 11 162
2017 February 86 17 103
2017 January 81 20 101
2016 December 118 18 136
2016 November 156 16 172
2016 October 159 25 184
2016 September 222 18 240
2016 August 141 15 156
2016 July 97 14 111
2016 June 20 15 35
2016 May 10 13 23
2016 April 7 4 11
2016 March 12 4 16
2016 February 13 1 14
2016 January 7 13 20
2015 December 10 2 12
2015 November 14 2 16
2015 October 15 1 16
2015 September 8 4 12
2015 August 13 6 19
2015 July 74 13 87
2015 June 73 9 82
2015 May 120 19 139
2015 April 98 15 113
2015 March 64 20 84
2015 February 80 18 98
2015 January 75 15 90
2014 December 81 12 93
2014 November 73 19 92
2014 October 73 18 91
2014 September 62 12 74
2014 August 57 21 78
2014 July 69 21 90
2014 June 96 18 114
2014 May 101 28 129
2014 April 68 17 85
2014 March 89 23 112
2014 February 77 17 94
2014 January 54 20 74
2013 December 64 14 78
2013 November 22 14 36
2013 October 10 14 24
2013 September 13 8 21
2013 August 18 71 89
2013 July 6 15 21
2013 June 12 26 38
2013 May 18 17 35
2013 April 11 17 28
2013 March 26 15 41
2013 February 39 5 44
2013 January 23 4 27
2012 December 22 7 29
2012 November 0 1 1
2012 October 1 2 3
Show all

Follow this link to access the full text of the article

Idiomas
Actas Dermo-Sifiliográficas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?