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Descriptive Dermoscopic Study of Depigmentation in Melanocytic Nevi Without a Visible Halo
Estudio descriptivo dermatoscópico de los nevos melanocíticos con despigmentación sin halo clínico
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Jordá" "autores" => array:6 [ 0 => array:4 [ "nombre" => "J.M." "apellidos" => "Martín" "email" => array:1 [ 0 => "Martin.josemaria@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "J." "apellidos" => "Núñez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 2 => array:3 [ "nombre" => "V." "apellidos" => "López" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 3 => array:3 [ "nombre" => "M." "apellidos" => "Rubio" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 4 => array:3 [ "nombre" => "C." "apellidos" => "Monteagudo" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0005" ] ] ] 5 => array:3 [ "nombre" => "E." "apellidos" => "Jordá" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital Clínico Universitario, Valencia, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Hospital Clínico Universitario, Universidad de Valencia, Valencia, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Estudio descriptivo dermatoscópico de los nevos melanocíticos con despigmentación sin halo clínico" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2010-06-27" "fechaAceptado" => "2010-10-27" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec84923" "palabras" => array:4 [ 0 => "Depigmentation" 1 => "Halo nevus" 2 => "Melanocytic nevus" 3 => "Regression" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84922" "palabras" => array:4 [ 0 => "Despigmentación" 1 => "Halo nevus" 2 => "Nevo melanocítico" 3 => "Regresión" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Background and objectives</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">There are few cases described in the literature in which depigmentation of melanocytic nevi occurs without the appearance of halos. The aim of this study was to analyze the correlation between clinical and dermoscopic findings and to assess the usefulness of dermoscopy to identify possible markers of complete regression in melanocytic lesions.</p> <span class="elsevierStyleSectionTitle">Materials and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A prospective, observational, descriptive study of 77 melanocytic lesions in 52 patients was undertaken over a 5-year period. Melanocytic lesions from patients who underwent periodic follow-up in the digital dermoscopy unit were analyzed if they had exhibited partial or total, permanent depigmentation without a clinically apparent halo.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">We observed substantial variation in the time taken for pigmentation to disappear and the morphological characteristics of the nevi during the depigmentation process. Female sex and dermoscopic evidence of melanophage activity or of a halo were all associated with more rapid involution of pigmented lesions. The only variable which displayed a statistically significant association with complete depigmentation of melanocytic nevi was the presence of vascular proliferation. Fibrosis was the only variable that displayed a statistically significant association with heterogeneous depigmentation of melanocytic nevi.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">In this study, we have identified patterns of depigmentation in melanocytic lesions that differ from the classic halo nevus.</p>" ] "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La despigmentación de nevos melanocíticos sin halo perilesional se ha descrito de forma excepcional en la literatura.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Estudio observacional, descriptivo y prospectivo de 77 lesiones melanocíticas correspondientes a 52 pacientes, llevado a cabo durante un período de 5 años. Se han analizado las lesiones melanocíticas de pacientes revisados periódicamente en la unidad de dermatoscopia digital que habían sufrido una despigmentación permanente, ya fuera total o parcial, pero sin presentar clínicamente un halo blanquecino alrededor de los mismos.</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">El objetivo fue estudiar la correlación entre los hallazgos clínicos y dermatoscópicos a estudio, y establecer el valor de la dermatoscopia para identificar posibles marcadores de regresión completa de lesiones melanocíticas.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Hemos observado mecanismos de despigmentación sin halo muy dispares, tanto en lo referente al tiempo que tardaban las lesiones en perder la pigmentación, como en las características morfológicas de los nevos durante el proceso de involución. La presencia de melanofagia, halo dermatoscópico y el sexo femenino fueron las variables que demostraron una asociación estadísticamente significativa, con un menor tiempo de involución de las lesiones pigmentadas. La existencia de proliferación vascular fue la única variable que demostró una asociación estadísticamente significativa con la despigmentación completa de los nevos melanocíticos. La existencia de fibrosis fue la única variable que ha demostrado una asociación estadísticamente significativa con la despigmentación heterogénea de los nevos melanocíticos.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">El presente estudio ha permitido identificar la existencia de patrones de despigmentación de lesiones melanocíticas diferentes al halo nevo clásico.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:30 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Spontaneous regression of cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R.J. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 8 | 12 | 20 |
| 2024 October | 80 | 48 | 128 |
| 2024 September | 85 | 26 | 111 |
| 2024 August | 85 | 41 | 126 |
| 2024 July | 60 | 36 | 96 |
| 2024 June | 69 | 26 | 95 |
| 2024 May | 56 | 36 | 92 |
| 2024 April | 55 | 32 | 87 |
| 2024 March | 48 | 34 | 82 |
| 2024 February | 48 | 32 | 80 |
| 2024 January | 38 | 43 | 81 |
| 2023 December | 54 | 38 | 92 |
| 2023 November | 58 | 55 | 113 |
| 2023 October | 47 | 32 | 79 |
| 2023 September | 50 | 36 | 86 |
| 2023 August | 41 | 35 | 76 |
| 2023 July | 43 | 62 | 105 |
| 2023 June | 40 | 25 | 65 |
| 2023 May | 37 | 40 | 77 |
| 2023 April | 27 | 28 | 55 |
| 2023 March | 18 | 18 | 36 |
| 2023 February | 25 | 16 | 41 |
| 2023 January | 28 | 32 | 60 |
| 2022 December | 46 | 44 | 90 |
| 2022 November | 22 | 28 | 50 |
| 2022 October | 16 | 27 | 43 |
| 2022 September | 16 | 33 | 49 |
| 2022 August | 25 | 58 | 83 |
| 2022 July | 15 | 27 | 42 |
| 2022 June | 19 | 32 | 51 |
| 2022 May | 32 | 52 | 84 |
| 2022 April | 28 | 40 | 68 |
| 2022 March | 28 | 51 | 79 |
| 2022 February | 23 | 32 | 55 |
| 2022 January | 23 | 58 | 81 |
| 2021 December | 27 | 45 | 72 |
| 2021 November | 27 | 64 | 91 |
| 2021 October | 25 | 67 | 92 |
| 2021 September | 28 | 60 | 88 |
| 2021 August | 21 | 42 | 63 |
| 2021 July | 12 | 37 | 49 |
| 2021 June | 19 | 46 | 65 |
| 2021 May | 20 | 29 | 49 |
| 2021 April | 29 | 66 | 95 |
| 2021 March | 42 | 13 | 55 |
| 2021 February | 29 | 27 | 56 |
| 2021 January | 22 | 11 | 33 |
| 2020 December | 9 | 14 | 23 |
| 2020 November | 19 | 23 | 42 |
| 2020 October | 22 | 18 | 40 |
| 2020 September | 21 | 14 | 35 |
| 2020 August | 18 | 26 | 44 |
| 2020 July | 20 | 9 | 29 |
| 2020 June | 29 | 20 | 49 |
| 2020 May | 20 | 32 | 52 |
| 2020 April | 22 | 13 | 35 |
| 2020 March | 20 | 30 | 50 |
| 2020 February | 2 | 10 | 12 |
| 2020 January | 0 | 17 | 17 |
| 2019 December | 0 | 8 | 8 |
| 2019 November | 0 | 12 | 12 |
| 2019 October | 0 | 7 | 7 |
| 2019 September | 0 | 8 | 8 |
| 2019 August | 0 | 7 | 7 |
| 2019 July | 0 | 3 | 3 |
| 2019 June | 0 | 14 | 14 |
| 2019 May | 0 | 47 | 47 |
| 2019 April | 0 | 4 | 4 |
| 2019 March | 0 | 9 | 9 |
| 2018 September | 0 | 5 | 5 |
| 2018 August | 0 | 3 | 3 |
| 2018 June | 0 | 2 | 2 |
| 2018 April | 0 | 1 | 1 |
| 2018 February | 10 | 4 | 14 |
| 2018 January | 14 | 10 | 24 |
| 2017 December | 16 | 7 | 23 |
| 2017 November | 19 | 6 | 25 |
| 2017 October | 15 | 4 | 19 |
| 2017 September | 29 | 7 | 36 |
| 2017 August | 28 | 14 | 42 |
| 2017 July | 22 | 1 | 23 |
| 2017 June | 40 | 17 | 57 |
| 2017 May | 33 | 21 | 54 |
| 2017 April | 39 | 20 | 59 |
| 2017 March | 34 | 31 | 65 |
| 2017 February | 23 | 8 | 31 |
| 2017 January | 14 | 11 | 25 |
| 2016 December | 36 | 1 | 37 |
| 2016 November | 27 | 6 | 33 |
| 2016 October | 29 | 18 | 47 |
| 2016 September | 29 | 6 | 35 |
| 2016 August | 29 | 10 | 39 |
| 2016 July | 25 | 6 | 31 |
| 2016 June | 9 | 5 | 14 |
| 2016 May | 6 | 14 | 20 |
| 2016 April | 7 | 3 | 10 |
| 2016 March | 2 | 9 | 11 |
| 2016 February | 4 | 9 | 13 |
| 2016 January | 11 | 9 | 20 |
| 2015 December | 11 | 7 | 18 |
| 2015 November | 12 | 12 | 24 |
| 2015 October | 9 | 7 | 16 |
| 2015 September | 5 | 6 | 11 |
| 2015 August | 14 | 4 | 18 |
| 2015 July | 25 | 10 | 35 |
| 2015 June | 35 | 0 | 35 |
| 2015 May | 72 | 7 | 79 |
| 2015 April | 32 | 11 | 43 |
| 2015 March | 35 | 5 | 40 |
| 2015 February | 20 | 5 | 25 |
| 2015 January | 36 | 7 | 43 |
| 2014 December | 33 | 5 | 38 |
| 2014 November | 28 | 11 | 39 |
| 2014 October | 36 | 12 | 48 |
| 2014 September | 29 | 8 | 37 |
| 2014 August | 31 | 12 | 43 |
| 2014 July | 32 | 17 | 49 |
| 2014 June | 42 | 12 | 54 |
| 2014 May | 38 | 9 | 47 |
| 2014 April | 44 | 8 | 52 |
| 2014 March | 55 | 16 | 71 |
| 2014 February | 28 | 14 | 42 |
| 2014 January | 37 | 11 | 48 |
| 2013 December | 44 | 14 | 58 |
| 2013 November | 30 | 18 | 48 |
| 2013 October | 27 | 24 | 51 |
| 2013 September | 29 | 22 | 51 |
| 2013 August | 25 | 20 | 45 |
| 2013 July | 38 | 24 | 62 |
| 2013 June | 39 | 19 | 58 |
| 2013 May | 5 | 16 | 21 |
| 2013 April | 8 | 16 | 24 |
| 2013 March | 6 | 12 | 18 |
| 2013 February | 5 | 7 | 12 |
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