BIOBADADERM, the Spanish Registry of Adverse Events Associated With Biologic Drugs in Dermatology: First Report
BIOBADADERM: registro español de acontecimientos adversos de terapias biológicas en Dermatología. Primer informe
R. Rivera
, I. García-Doval, G. Carretero, E. Daudén, J. Sánchez-Carazo, C. Ferrándiz, E. Herrera, M. Alsina, M. Ferrán, J.L. López-Estebaranz, F. Gómez, J.M. Herranz, J.M. Carrascosa, F. Vanaclocha, members of the BIOBADADERM Group
Corresponding author
Members of the BIOBADADERM Group and the Working Group on Psoriasis of the Spanish Academy of Dermatology and Venereology
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García-Doval, G. Carretero, E. Daudén, J. Sánchez-Carazo, C. Ferrándiz, E. Herrera, M. Alsina, M. Ferrán, J.L. López-Estebaranz, F. Gómez, J.M. Herranz, J.M. Carrascosa, F. Vanaclocha" "autores" => array:15 [ 0 => array:4 [ "nombre" => "R." "apellidos" => "Rivera" "email" => array:1 [ 0 => "rriveradiaz@hotmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "I." "apellidos" => "García-Doval" ] 2 => array:2 [ "nombre" => "G." "apellidos" => "Carretero" ] 3 => array:2 [ "nombre" => "E." "apellidos" => "Daudén" ] 4 => array:2 [ "nombre" => "J." "apellidos" => "Sánchez-Carazo" ] 5 => array:2 [ "nombre" => "C." "apellidos" => "Ferrándiz" ] 6 => array:2 [ "nombre" => "E." "apellidos" => "Herrera" ] 7 => array:2 [ "nombre" => "M." "apellidos" => "Alsina" ] 8 => array:2 [ "nombre" => "M." "apellidos" => "Ferrán" ] 9 => array:2 [ "nombre" => "J.L." "apellidos" => "López-Estebaranz" ] 10 => array:2 [ "nombre" => "F." "apellidos" => "Gómez" ] 11 => array:2 [ "nombre" => "J.M." "apellidos" => "Herranz" ] 12 => array:2 [ "nombre" => "J.M." "apellidos" => "Carrascosa" ] 13 => array:2 [ "nombre" => "F." "apellidos" => "Vanaclocha" ] 14 => array:1 [ "colaborador" => "members of the BIOBADADERM Group" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Members of the BIOBADADERM Group and the Working Group on Psoriasis of the Spanish Academy of Dermatology and Venereology" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "BIOBADADERM: registro español de acontecimientos adversos de terapias biológicas en Dermatología. Primer informe" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2010-09-21" "fechaAceptado" => "2010-10-17" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec84847" "palabras" => array:7 [ 0 => "Biologic therapies" 1 => "Psoriasis" 2 => "Adverse events" 3 => "Registry" 4 => "Incidence" 5 => "Prognosis" 6 => "Cohort" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras Clave" "identificador" => "xpalclavsec84846" "palabras" => array:7 [ 0 => "Tratamientos biológicos" 1 => "Psoriasis" 2 => "Acontecimientos adversos" 3 => "Registro" 4 => "Incidencia" 5 => "Pronóstico" 6 => "Cohorte" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Background and objectives</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The Working Group on Psoriasis of the Spanish Academy of Dermatology and Venereology has initiated BIOBADADERM, a registry of patients with psoriasis receiving treatment with biologic drugs, in order to assess the long-term risk of adverse events (AEs).</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A multicenter study was undertaken in 2 cohorts of patients with psoriasis: patients receiving biologic therapy and patients receiving nonbiologic systemic therapy other than phototherapy. Similar numbers of patients were included in each group. Information was recorded on demographic and clinical variables, treatment, and relevant AEs. The risk of specific AEs was determined by comparison of the frequencies for those events in the 2 cohorts.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Data on the 2 cohorts were evaluated for the period from October, 2008 to November, 2009 alongside retrospective data on patients treated with biologics since 2005. Thirteen Spanish hospitals participated in the study. A total of 632 patients were included in the analysis: 417 treated with biologic drugs and 215 controls. Suspension of biologic therapy due to AEs was rare (72 cycles, 10%). A total of 232 AEs were reported in patients receiving biologic therapy. The majority were not serious. The most frequent AEs were infections (mostly upper respiratory tract infections and nasopharyngitis), followed by conditions affecting the skin or subcutaneous tissue. Forty-three AEs were reported in control subjects. The most frequent events were metabolic and nutritional abnormalities and abnormal transaminase levels. Comparison of the incidence of any AE in patients treated with biologics compared with control subjects revealed a relative risk of 2.2 (P<.001) The relative risks of infections or infestations and disorders of the skin or subcutaneous tissue in patients receiving biologic drugs were 23 (P<.01) and 4.9 (P<.05), respectively.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Patients treated with biologic drugs had a greater number of AEs, particularly infections and skin conditions. Definitive conclusions, however, are difficult to draw due to the small number of patients included in the registry, particularly in the control cohort, and the short follow-up period. Differences in the percentages of events reported by the different hospitals reveal the difficulties associated with the concept of AEs in clinical practice and highlight the need to harmonize criteria in the future. Since the problems identified in this analysis should be overcome in future years, we expect BIOBADADERM to become an important source of information on the safety profile of biologic drugs in dermatology.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción y objetivos</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">El Grupo de Psoriasis de la Academia Española de Dermatología y Venereología (AEDV) ha puesto en marcha un registro de pacientes con psoriasis en tratamiento con agentes biológicos, con el objetivo de analizar el riesgo de acontecimientos adversos (AA) relevantes a largo plazo: BIOBADADERM.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Es un estudio de cohortes multicéntrico, con una cohorte de pacientes con psoriasis en terapia biológica y otra cohorte control de pacientes con psoriasis con tratamiento sistémico no biológico, excluida la fototerapia, en una relación 1:1. Se registraron los datos básicos de cada paciente, de los tratamientos y de los AA relevantes. Se analizó el riesgo asociado a un AA concreto, comparando su frecuencia de aparición en ambas cohortes.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Se evaluaron los datos desde octubre de 2008 hasta noviembre de 2009 junto con datos retrospectivos desde 2005 sobre pacientes tratados con agentes biológicos. Participaron 13 hospitales de España. Se incluyeron 632 pacientes, 417 con biológicos y 215 controles. La suspensión del tratamiento biológico por AA fue poco frecuente (72 ciclos, 10%). Se comunicaron 232 AA en los pacientes con biológicos, la mayoría no graves, los más frecuentes las infecciones (la mayoría del tracto respiratorio superior/nasofaringitis), seguidos de los trastornos de la piel y el tejido subcutáneo. Entre los controles se notificaron 43 AA. Los más frecuentes fueron los trastornos del metabolismo y la nutrición y las alteraciones en las transaminasas. En términos de incidencia de AA, los biológicos presentaron un riesgo relativo (RR) de AA de 2,2 respecto a los controles (p < 0,001). En particular destacaron las infecciones e infestaciones (con un RR de 23 con p<0,01) y los trastornos de la piel y el tejido subcutáneo (RR: 4,9 con p < 0,05).</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Los pacientes tratados con fármacos biológicos presentan mayor número de AA que los controles, en particular en referencia a las infecciones y los trastornos de la piel. Sin embargo, debe tenerse en cuenta que tanto el tiempo de seguimiento como el limitado número de pacientes reclutados —en particular en el grupo de controles— impide extraer conclusiones definitivas. Por otro lado, la diferencia de porcentajes de AA referidos por los distintos centros pone de manifiesto la dificultad de la consideración del concepto de AA en la práctica clínica, siendo necesario homogeneizar los criterios. un a pesar de los problemas planteados, que deberán superarse en los próximos años, BIOBADADERM puede convertirse en la referencia obligada en la evaluación del perfil de seguridad de los fármacos biológicos en Dermatología.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:13 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The meaning of safe and effective" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Albretch" 1 => "M. Bigby" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1067/mjd.2003.134" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol." "fecha" => "2003" "volumen" => "48" "paginaInicial" => "144" "paginaFinal" => "147" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12522386" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Comité científico de Biobadaser. SER. BIOBADASER: registro español de acontecimientos adversos de terapias biológicas en enfermedades reumáticas. Rev Esp Reumatol. 2002;29:292-99." ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "PsoReg-The Swedish Registry for Systemic Psoriasis Treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M. Schmitt-Egenolf" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1159/000098568" "Revista" => array:6 [ "tituloSerie" => "Dermatology." "fecha" => "2007" "volumen" => "214" "paginaInicial" => "112" "paginaFinal" => "117" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17341858" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Three-year registry data on biological treatment for psoriasis: the influence of patient characteristics on treatment outcome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R.J.B. Driessen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2008.09019.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol." "fecha" => "2009" "volumen" => "160" "paginaInicial" => "670" "paginaFinal" => "675" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19210502" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "National Registries of Systemic Treatment for Psoriass and the European “Psonet” Initiative" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "L.L.A. Lecluse" 1 => "L. Naldi" 2 => "R.S. Stern" 3 => "P.I. Spuls" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1159/000183757" "Revista" => array:7 [ "tituloSerie" => "Dermatology." "fecha" => "2009" "volumen" => "218" "paginaInicial" => "347" "paginaFinal" => "356" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19077384" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0140673602110798" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Gordon K, Leonardi C, Lebwohl M, Yeilding N, Szapary P, Wang Y, et al. Experiencia de seguridad de ustekinumab en pacientes con psoriasis de moderada a grave: resultados de análisis de datos agrupados de los ensayos en Fase 2 y Fase 3. Póster presentado en el Congreso EADV. Berlin, 7-11 octubre de 2009. P1170. Available from: <a class="elsevierStyleInterRef" href="http://www.%20aedv.es/grupo%20psoriasis/tratamientos/USTEKINUMAB/GORDON%20SAFETY.pdf">http://www. aedv.es/grupo psoriasis/tratamientos/USTEKINUMAB/GORDON SAFETY.pdf</a>" ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "EULAR points to consider when establishing, analysing and reporting safety data of biologics registers in rheumatology" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "W.G. Dixon" 1 => "L. Carmona" 2 => "A. Finckh" 3 => "M.L. Hetland" 4 => "T.K. Kvien" 5 => "R. Landewe" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/ard.2009.125526" "Revista" => array:6 [ "tituloSerie" => "Ann Rheum Dis." "fecha" => "2010" "volumen" => "69" "paginaInicial" => "1596" "paginaFinal" => "1602" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20525843" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Standardizing Assessment and Reporting of Adverse Effects in Rheumatology Clinical Trials II: the Rheumatology Common Toxicity Criteria v.2.0" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "T. Woodworth" 1 => "D.E. Furst" 2 => "R. Alten" 3 => "C. Bingham" 4 => "D. Yocum" 5 => "V. Sloan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Rheumatol." "fecha" => "2007" "volumen" => "34" "paginaInicial" => "1401" "paginaFinal" => "1414" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17552067" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Documento de consenso sobre la evaluación y el tratamiento de la psoriasis grave/moderada del Grupo Español de psoriasis de la Academia Española de Dermatología y Venereología" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L. Puig" 1 => "X. Bordas" 2 => "J.M. Carrascosa" 3 => "E. Daudén" 4 => "C. Ferrándiz" 5 => "J.M. Hernanz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr." "fecha" => "2009" "volumen" => "100" "paginaInicial" => "277" "paginaFinal" => "286" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19463230" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Directrices españolas basadas en la evidencia para el tratamiento de la psoriasis moderada a grave con agentes biológicos" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "L. Puig" 1 => "J.M. Carrascosa" 2 => "E. Daudén" 3 => "J.L. Sánchez-Carazo" 4 => "C. Ferrándiz" 5 => "Sánchez-Regaña" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr." "fecha" => "2009" "volumen" => "100" "paginaInicial" => "386" "paginaFinal" => "413" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19558918" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "European S3-Guidelines on the systemic treatment of psoriasis vulgaris" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D. Pathirana" 1 => "A.D. Ormerod" 2 => "P. Saiag" 3 => "C. Smith" 4 => "P.I. Spuls" 5 => "A. Nast" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "JEADV." "fecha" => "2009" "volumen" => "23Suppl2" "paginaInicial" => "5" "paginaFinal" => "70" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Guidelines of care for the management of psoriasis an psoriatic arthritis Section 1. Overview of psoriasis and guidelines of care for the treatment of psoriasis with biologics" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Menter" 1 => "A. Gottlieb" 2 => "S.R. Feldman" 3 => "A.S. Van Voorhees" 4 => "C.L. Leonardi" 5 => "K.B. Gordon" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2008.02.039" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol." "fecha" => "2008" "volumen" => "58" "paginaInicial" => "826" "paginaFinal" => "850" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18423260" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 4 | 4 | 8 |
| 2024 October | 69 | 51 | 120 |
| 2024 September | 64 | 22 | 86 |
| 2024 August | 100 | 57 | 157 |
| 2024 July | 68 | 41 | 109 |
| 2024 June | 77 | 33 | 110 |
| 2024 May | 54 | 37 | 91 |
| 2024 April | 57 | 27 | 84 |
| 2024 March | 50 | 35 | 85 |
| 2024 February | 43 | 38 | 81 |
| 2024 January | 35 | 30 | 65 |
| 2023 December | 47 | 26 | 73 |
| 2023 November | 52 | 73 | 125 |
| 2023 October | 42 | 39 | 81 |
| 2023 September | 45 | 25 | 70 |
| 2023 August | 25 | 13 | 38 |
| 2023 July | 30 | 41 | 71 |
| 2023 June | 43 | 30 | 73 |
| 2023 May | 36 | 24 | 60 |
| 2023 April | 30 | 25 | 55 |
| 2023 March | 21 | 20 | 41 |
| 2023 February | 23 | 20 | 43 |
| 2023 January | 18 | 22 | 40 |
| 2022 December | 20 | 52 | 72 |
| 2022 November | 17 | 26 | 43 |
| 2022 October | 9 | 17 | 26 |
| 2022 September | 23 | 40 | 63 |
| 2022 August | 31 | 43 | 74 |
| 2022 July | 12 | 30 | 42 |
| 2022 June | 13 | 22 | 35 |
| 2022 May | 22 | 42 | 64 |
| 2022 April | 21 | 39 | 60 |
| 2022 March | 27 | 40 | 67 |
| 2022 February | 31 | 37 | 68 |
| 2022 January | 21 | 49 | 70 |
| 2021 December | 29 | 33 | 62 |
| 2021 November | 37 | 52 | 89 |
| 2021 October | 26 | 53 | 79 |
| 2021 September | 33 | 54 | 87 |
| 2021 August | 20 | 35 | 55 |
| 2021 July | 17 | 37 | 54 |
| 2021 June | 23 | 23 | 46 |
| 2021 May | 25 | 27 | 52 |
| 2021 April | 86 | 55 | 141 |
| 2021 March | 61 | 15 | 76 |
| 2021 February | 62 | 22 | 84 |
| 2021 January | 25 | 17 | 42 |
| 2020 December | 26 | 13 | 39 |
| 2020 November | 16 | 18 | 34 |
| 2020 October | 14 | 16 | 30 |
| 2020 September | 26 | 19 | 45 |
| 2020 August | 22 | 18 | 40 |
| 2020 July | 20 | 16 | 36 |
| 2020 June | 15 | 19 | 34 |
| 2020 May | 22 | 12 | 34 |
| 2020 April | 11 | 15 | 26 |
| 2020 March | 11 | 18 | 29 |
| 2020 February | 5 | 2 | 7 |
| 2020 January | 0 | 3 | 3 |
| 2019 December | 0 | 10 | 10 |
| 2019 November | 0 | 2 | 2 |
| 2019 September | 0 | 2 | 2 |
| 2019 August | 0 | 4 | 4 |
| 2019 July | 0 | 1 | 1 |
| 2019 June | 0 | 1 | 1 |
| 2019 May | 1 | 48 | 49 |
| 2019 April | 0 | 1 | 1 |
| 2019 March | 0 | 7 | 7 |
| 2018 September | 0 | 3 | 3 |
| 2018 August | 0 | 2 | 2 |
| 2018 June | 0 | 1 | 1 |
| 2018 May | 0 | 2 | 2 |
| 2018 April | 0 | 7 | 7 |
| 2018 March | 4 | 4 | 8 |
| 2018 February | 17 | 8 | 25 |
| 2018 January | 12 | 3 | 15 |
| 2017 December | 18 | 8 | 26 |
| 2017 November | 18 | 1 | 19 |
| 2017 October | 15 | 9 | 24 |
| 2017 September | 19 | 6 | 25 |
| 2017 August | 28 | 11 | 39 |
| 2017 July | 29 | 5 | 34 |
| 2017 June | 36 | 13 | 49 |
| 2017 May | 31 | 7 | 38 |
| 2017 April | 29 | 7 | 36 |
| 2017 March | 25 | 15 | 40 |
| 2017 February | 26 | 14 | 40 |
| 2017 January | 20 | 4 | 24 |
| 2016 December | 25 | 9 | 34 |
| 2016 November | 25 | 8 | 33 |
| 2016 October | 22 | 9 | 31 |
| 2016 September | 39 | 8 | 47 |
| 2016 August | 44 | 10 | 54 |
| 2016 July | 32 | 5 | 37 |
| 2016 June | 6 | 6 | 12 |
| 2016 May | 10 | 4 | 14 |
| 2016 April | 5 | 4 | 9 |
| 2016 March | 2 | 7 | 9 |
| 2016 February | 13 | 1 | 14 |
| 2016 January | 5 | 9 | 14 |
| 2015 December | 7 | 7 | 14 |
| 2015 November | 5 | 12 | 17 |
| 2015 October | 8 | 4 | 12 |
| 2015 September | 10 | 3 | 13 |
| 2015 August | 11 | 4 | 15 |
| 2015 July | 41 | 11 | 52 |
| 2015 June | 52 | 14 | 66 |
| 2015 May | 82 | 13 | 95 |
| 2015 April | 51 | 18 | 69 |
| 2015 March | 37 | 15 | 52 |
| 2015 February | 36 | 12 | 48 |
| 2015 January | 18 | 11 | 29 |
| 2014 December | 27 | 19 | 46 |
| 2014 November | 19 | 15 | 34 |
| 2014 October | 34 | 21 | 55 |
| 2014 September | 29 | 13 | 42 |
| 2014 August | 22 | 19 | 41 |
| 2014 July | 46 | 19 | 65 |
| 2014 June | 54 | 10 | 64 |
| 2014 May | 49 | 14 | 63 |
| 2014 April | 34 | 10 | 44 |
| 2014 March | 53 | 23 | 76 |
| 2014 February | 30 | 21 | 51 |
| 2014 January | 39 | 13 | 52 |
| 2013 December | 46 | 9 | 55 |
| 2013 November | 28 | 25 | 53 |
| 2013 October | 27 | 15 | 42 |
| 2013 September | 34 | 27 | 61 |
| 2013 August | 22 | 16 | 38 |
| 2013 July | 27 | 27 | 54 |
| 2013 June | 26 | 30 | 56 |
| 2013 May | 14 | 25 | 39 |
| 2013 April | 26 | 31 | 57 |
| 2013 March | 22 | 18 | 40 |
| 2013 February | 4 | 9 | 13 |
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