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Plaque-Phase Mycosis Fungoides Treated with Photodynamic Therapy: Results from 12 Patients
Micosis fungoide en fase de placas tratada con terapia fotodinámica: resultados en 12 pacientes
M. Fernández-Guarino
, A. Harto, B. Pérez-García, C. Montull, E. De Las Heras, P. Jaén
Corresponding author
Servicio de Dermatología, Hospital Universitario Ramón y Cajal, Universidad de Alcalá, Madrid, Spain
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Guerra-Tapia, L. Puig-Sanz, J. Conejo Mir, J. Toribio-Pérez, C. Iglesias, I. Zsolt" "autores" => array:6 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Guerra-Tapia" ] 1 => array:2 [ "nombre" => "L." "apellidos" => "Puig-Sanz" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "Conejo Mir" ] 3 => array:2 [ "nombre" => "J." "apellidos" => "Toribio-Pérez" ] 4 => array:2 [ "nombre" => "C." "apellidos" => "Iglesias" ] 5 => array:2 [ "nombre" => "I." "apellidos" => "Zsolt" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219010707162?idApp=UINPBA000044" "url" => "/15782190/0000010100000009/v1_201304241531/S1578219010707162/v1_201304241531/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Plaque-Phase Mycosis Fungoides Treated with Photodynamic Therapy: Results from 12 Patients" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "785" "paginaFinal" => "791" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "M. Fernández-Guarino, A. Harto, B. Pérez-García, C. Montull, E. De Las Heras, P. Jaén" "autores" => array:6 [ 0 => array:4 [ "nombre" => "M." "apellidos" => "Fernández-Guarino" "email" => array:1 [ 0 => "montsefdez@msn.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Harto" ] 2 => array:2 [ "nombre" => "B." "apellidos" => "Pérez-García" ] 3 => array:2 [ "nombre" => "C." "apellidos" => "Montull" ] 4 => array:2 [ "nombre" => "E." "apellidos" => "De Las Heras" ] 5 => array:2 [ "nombre" => "P." "apellidos" => "Jaén" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Dermatología, Hospital Universitario Ramón y Cajal, Universidad de Alcalá, Madrid, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Micosis fungoide en fase de placas tratada con terapia fotodinámica: resultados en 12 pacientes" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2010-02-07" "fechaAceptado" => "2010-06-10" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec84807" "palabras" => array:3 [ 0 => "Mycosis fungoides" 1 => "Photodynamic therapy" 2 => "Methyl aminolevulinate" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84806" "palabras" => array:3 [ 0 => "Micosis fungoide" 1 => "Terapia fotodinámica" 2 => "Metilaminolevulínico" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Recent years have seen an increase in the off-label use of photodynamic therapy for the treatment of a variety of skin diseases. Plaque-phase mycosis fungoides is among the most promising possibilities for the use of this treatment.</p> <span class="elsevierStyleSectionTitle">Objectives</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To evaluate the treatment of plaque-phase mycosis fungoides with photodynamic therapy and compare the results obtained using fluorescence photography.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">We performed a prospective, descriptive, observational study. Twelve patients with 24 lesions were treated with topical methyl aminolevulinate (MAL) under an occlusive dressing for 3 hours, followed by 8 minutes of red light (630 nm, 37 J/ cm<span class="elsevierStyleSup">2</span>; Aktilite).</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Six patients had a complete response, 5 a partial response, and 1 did not respond to treatment. A mean of 5.7 sessions was applied and no side effects were reported. Treatment tolerance was excellent.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Photodynamic therapy with MAL appears to be a good treatment option for patients with plaque-phase mycosis fungoides with a small number of lesions.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">La terapia fotodinámica (TFD) está siendo desarrollada en los últimos años en dermatosis diferentes de las aprobadas para su uso. Entre todas ellas, la micosis fungoide (MF) en estadio de placas es una de las más prometedoras.</p> <span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Evaluar los resultados en el tratamiento de la MF en placas con TFD y correlacionarlos con la fotografía de fluorescencia.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Llevamos a cabo un estudio prospectivo, descriptivo y observacional. Se seleccionaron un total de 12 pacientes con 24 lesiones que fueron tratados con metilaminolevulinato (MAL) tópico ocluido tres horas y luz roja (630 nm, 37 J/cm<span class="elsevierStyleSup">2</span>, 8 min, Aktilite<span class="elsevierStyleSup">®</span>).</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Un total de 6 pacientes obtuvo respuesta completa, 5 pacientes alcanzaron respuesta parcial y uno no respondió al tratamiento. La media de sesiones aplicadas fue de 5,7 y no se recopilaron efectos secundarios. La tolerancia fue excelente.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">La TFD con MAL parece una buena alternativa terapéutica para los pacientes con MF en placas con escaso número de lesiones.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:17 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Otras indicaciones dermatológicas del ALAPDT" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "E.M. Welch" 1 => "K. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 9 | 11 | 20 |
| 2024 October | 50 | 48 | 98 |
| 2024 September | 63 | 25 | 88 |
| 2024 August | 70 | 65 | 135 |
| 2024 July | 56 | 33 | 89 |
| 2024 June | 58 | 20 | 78 |
| 2024 May | 44 | 23 | 67 |
| 2024 April | 54 | 27 | 81 |
| 2024 March | 49 | 33 | 82 |
| 2024 February | 53 | 38 | 91 |
| 2024 January | 43 | 40 | 83 |
| 2023 December | 49 | 24 | 73 |
| 2023 November | 51 | 41 | 92 |
| 2023 October | 41 | 28 | 69 |
| 2023 September | 38 | 26 | 64 |
| 2023 August | 21 | 21 | 42 |
| 2023 July | 36 | 40 | 76 |
| 2023 June | 54 | 23 | 77 |
| 2023 May | 49 | 21 | 70 |
| 2023 April | 36 | 25 | 61 |
| 2023 March | 25 | 28 | 53 |
| 2023 February | 23 | 25 | 48 |
| 2023 January | 32 | 37 | 69 |
| 2022 December | 37 | 40 | 77 |
| 2022 November | 18 | 22 | 40 |
| 2022 October | 15 | 15 | 30 |
| 2022 September | 16 | 49 | 65 |
| 2022 August | 16 | 55 | 71 |
| 2022 July | 15 | 26 | 41 |
| 2022 June | 14 | 27 | 41 |
| 2022 May | 21 | 41 | 62 |
| 2022 April | 28 | 43 | 71 |
| 2022 March | 34 | 56 | 90 |
| 2022 February | 22 | 21 | 43 |
| 2022 January | 27 | 49 | 76 |
| 2021 December | 27 | 47 | 74 |
| 2021 November | 32 | 53 | 85 |
| 2021 October | 23 | 57 | 80 |
| 2021 September | 18 | 50 | 68 |
| 2021 August | 15 | 30 | 45 |
| 2021 July | 17 | 41 | 58 |
| 2021 June | 14 | 27 | 41 |
| 2021 May | 25 | 23 | 48 |
| 2021 April | 33 | 44 | 77 |
| 2021 March | 34 | 23 | 57 |
| 2021 February | 47 | 25 | 72 |
| 2021 January | 38 | 25 | 63 |
| 2020 December | 17 | 18 | 35 |
| 2020 November | 33 | 20 | 53 |
| 2020 October | 14 | 12 | 26 |
| 2020 September | 7 | 7 | 14 |
| 2020 August | 31 | 27 | 58 |
| 2020 July | 10 | 9 | 19 |
| 2020 June | 22 | 26 | 48 |
| 2020 May | 25 | 18 | 43 |
| 2020 April | 30 | 27 | 57 |
| 2020 March | 21 | 21 | 42 |
| 2020 February | 0 | 2 | 2 |
| 2020 January | 0 | 2 | 2 |
| 2019 December | 0 | 12 | 12 |
| 2019 November | 0 | 1 | 1 |
| 2019 October | 0 | 7 | 7 |
| 2019 September | 0 | 2 | 2 |
| 2019 August | 0 | 4 | 4 |
| 2019 July | 0 | 4 | 4 |
| 2019 June | 0 | 1 | 1 |
| 2019 May | 0 | 36 | 36 |
| 2019 April | 0 | 9 | 9 |
| 2019 March | 0 | 5 | 5 |
| 2019 February | 0 | 1 | 1 |
| 2018 December | 0 | 2 | 2 |
| 2018 October | 0 | 3 | 3 |
| 2018 March | 1 | 1 | 2 |
| 2018 February | 17 | 2 | 19 |
| 2018 January | 9 | 6 | 15 |
| 2017 December | 14 | 7 | 21 |
| 2017 November | 13 | 1 | 14 |
| 2017 October | 10 | 6 | 16 |
| 2017 September | 13 | 3 | 16 |
| 2017 August | 11 | 4 | 15 |
| 2017 July | 12 | 3 | 15 |
| 2017 June | 17 | 5 | 22 |
| 2017 May | 13 | 5 | 18 |
| 2017 April | 13 | 7 | 20 |
| 2017 March | 10 | 5 | 15 |
| 2017 February | 12 | 7 | 19 |
| 2017 January | 11 | 5 | 16 |
| 2016 December | 20 | 7 | 27 |
| 2016 November | 25 | 1 | 26 |
| 2016 October | 39 | 12 | 51 |
| 2016 September | 30 | 5 | 35 |
| 2016 August | 26 | 6 | 32 |
| 2016 July | 25 | 4 | 29 |
| 2016 June | 6 | 6 | 12 |
| 2016 May | 3 | 0 | 3 |
| 2016 April | 4 | 1 | 5 |
| 2016 March | 3 | 1 | 4 |
| 2016 February | 7 | 7 | 14 |
| 2016 January | 8 | 0 | 8 |
| 2015 December | 13 | 0 | 13 |
| 2015 November | 14 | 0 | 14 |
| 2015 October | 5 | 6 | 11 |
| 2015 September | 1 | 3 | 4 |
| 2015 August | 17 | 3 | 20 |
| 2015 July | 21 | 3 | 24 |
| 2015 June | 25 | 2 | 27 |
| 2015 May | 50 | 9 | 59 |
| 2015 April | 28 | 5 | 33 |
| 2015 March | 29 | 3 | 32 |
| 2015 February | 33 | 6 | 39 |
| 2015 January | 23 | 6 | 29 |
| 2014 December | 17 | 14 | 31 |
| 2014 November | 18 | 12 | 30 |
| 2014 October | 27 | 14 | 41 |
| 2014 September | 13 | 12 | 25 |
| 2014 August | 29 | 12 | 41 |
| 2014 July | 38 | 20 | 58 |
| 2014 June | 23 | 11 | 34 |
| 2014 May | 33 | 15 | 48 |
| 2014 April | 21 | 9 | 30 |
| 2014 March | 24 | 18 | 42 |
| 2014 February | 17 | 16 | 33 |
| 2014 January | 25 | 14 | 39 |
| 2013 December | 24 | 8 | 32 |
| 2013 November | 24 | 14 | 38 |
| 2013 October | 25 | 19 | 44 |
| 2013 September | 24 | 19 | 43 |
| 2013 August | 18 | 17 | 35 |
| 2013 July | 35 | 26 | 61 |
| 2013 June | 15 | 17 | 32 |
| 2013 May | 24 | 18 | 42 |
| 2013 April | 25 | 19 | 44 |
| 2013 March | 27 | 36 | 63 |
| 2013 February | 12 | 12 | 24 |
| 2013 January | 2 | 1 | 3 |
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