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Increased Risk of Developing a Second Primary Cutaneous Nevus-Associated Melanoma in Patients Previously Diagnosed with the Disease
Riesgo aumentado del desarrollo de un segundo melanoma cutáneo primario sobre un nevo en pacientes diagnosticados previamente de melanoma cutáneo primario sobre nevo
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"apellidos" => "Echeverría" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "R." "apellidos" => "Botella-Estrada" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "C." "apellidos" => "Serra-Guillén" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "A." "apellidos" => "Martorell" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "V." "apellidos" => "Traves" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 5 => array:3 [ "nombre" => "C." "apellidos" => "Requena" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 6 => array:3 [ "nombre" => "O." "apellidos" => "Sanmartín" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 7 => array:3 [ "nombre" => "B." "apellidos" => "Llombart" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 8 => array:3 [ "nombre" => "C." "apellidos" => "Guillén" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 9 => array:4 [ "nombre" => "E." "apellidos" => "Nagore" "email" => array:1 [ 0 => "eduyame@meditex.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Anatomía Patológica, Instituto Valenciano de Oncología, Valencia, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Riesgo aumentado del desarrollo de un segundo melanoma cutáneo primario sobre un nevo en pacientes diagnosticados previamente de melanoma cutáneo primario sobre nevo" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2009-11-26" "fechaAceptado" => "2010-03-11" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec84803" "palabras" => array:4 [ 0 => "Nevus-associated melanoma" 1 => "Second melanomas" 2 => "Risk factors" 3 => "Multiple melanoma" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84802" "palabras" => array:4 [ 0 => "Melanoma sobre nevo" 1 => "Segundos melanomas" 2 => "Factores de riesgo" 3 => "Melanoma múltiple" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Patients diagnosed with primary cutaneous melanoma have a greater lifetime risk of developing further melanomas. Most of these melanomas appear to arise de novo, but a proportion of them develop in pre-existing melanocytic nevi.</p> <span class="elsevierStyleSectionTitle">Objective</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To determine risk factors associated with the development of a second cutaneous melanoma arising on a nevus in patients diagnosed with cutaneous melanoma.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A series of 981 patients diagnosed with cutaneous melanoma was selected; 47 of them had been diagnosed with a second melanoma. These 47 patients were classified into 2 groups according to whether or not there was histological evidence that the melanoma was associated with a nevus.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Age at diagnosis less than 40 years, tumor location on the trunk, and superficial spreading subtype were independent risk factors for the appearance of a primary melanoma on a nevus. The only factor associated with the appearance of a second nevusassociated melanoma was that the first melanoma was also associated with a nevus (odds ratio, 9.51; 95% confidence interval 1.6–56.56; P=.042).</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Nevus-associated melanomas develop mainly in young patients, on the trunk, and are of the superficial spreading subtype. A history of primary cutaneous melanoma arising on a nevus is associated with a 9-fold increase in the risk of developing a second nevus-associated melanoma. These findings highlight the need for careful follow-up of all melanocytic lesions in patients who have had a primary nevus-associated melanoma.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Antecedentes</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Los pacientes diagnosticados de un melanoma cutáneo tienen más riesgo que el resto de la población de padecer nuevos melanomas a lo largo de su vida. La mayoría de estos melanomas aparecen «de novo», pero existe un porcentaje de ellos que se desarrolla sobre nevos melanocíticos previos.</p> <span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Determinar los factores de riesgo asociados al desarrollo de un segundo melanoma cutáneo sobre nevo en pacientes diagnosticados de melanoma cutáneo.</p> <span class="elsevierStyleSectionTitle">Métodos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Se seleccionaron los datos de 981 pacientes diagnosticados de un primer melanoma cutáneo, 47 de los cuales habían sido diagnosticados de un segundo melanoma. Todos los pacientes fueron clasificados en función de si el melanoma presentó o no asociación histológica a un nevo.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">La edad inferior a 40 años, la localización en el tronco y el subtipo histológico de extensión superficial fueron los factores de riesgo independientes asociados al desarrollo de un primer melanoma sobre nevo. El único factor asociado al desarrollo de un segundo melanoma sobre nevo fue que el primer melanoma también se hubiera presentado asociado a un nevo (OR: 9,51, 95% de intervalo de confianza: 1,6–56,56; p = 0,042).</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Los melanomas se desarrollan asociados a un nevo principalmente en pacientes jóvenes, en el tronco y del subtipo tipo de extensión superficial. A su vez, el desarrollo de un primer melanoma sobre nevo aumenta el riesgo hasta 9 veces de desarrollar un segundo melanoma sobre un nevo previo. Estos hallazgos subrayan la importancia del seguimiento estrecho de todas las lesiones melánicas en los pacientes que han desarrollado un primer melanoma sobre nevo.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:12 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "p53 expression and risk factors for cutaneous melanoma: a case-control study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D.C. Whiteman" 1 => "P.G. Parsons" 2 => "A.C. 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Morton" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "2001" "volumen" => "91" "paginaInicial" => "1520" "paginaFinal" => "1524" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11301400" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010100000008/v1_201304241529/S1578219010707010/v1_201304241529/en/main.assets" "Apartado" => array:4 [ "identificador" => "6256" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original article" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010100000008/v1_201304241529/S1578219010707010/v1_201304241529/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219010707010?idApp=UINPBA000044" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 13 | 17 | 30 |
| 2024 October | 53 | 33 | 86 |
| 2024 September | 51 | 29 | 80 |
| 2024 August | 102 | 68 | 170 |
| 2024 July | 99 | 35 | 134 |
| 2024 June | 52 | 15 | 67 |
| 2024 May | 71 | 25 | 96 |
| 2024 April | 62 | 24 | 86 |
| 2024 March | 55 | 22 | 77 |
| 2024 February | 45 | 35 | 80 |
| 2024 January | 35 | 38 | 73 |
| 2023 December | 40 | 18 | 58 |
| 2023 November | 42 | 33 | 75 |
| 2023 October | 59 | 46 | 105 |
| 2023 September | 48 | 28 | 76 |
| 2023 August | 26 | 22 | 48 |
| 2023 July | 49 | 62 | 111 |
| 2023 June | 31 | 36 | 67 |
| 2023 May | 37 | 33 | 70 |
| 2023 April | 28 | 22 | 50 |
| 2023 March | 21 | 23 | 44 |
| 2023 February | 21 | 11 | 32 |
| 2023 January | 27 | 23 | 50 |
| 2022 December | 35 | 43 | 78 |
| 2022 November | 13 | 30 | 43 |
| 2022 October | 13 | 11 | 24 |
| 2022 September | 11 | 40 | 51 |
| 2022 August | 16 | 37 | 53 |
| 2022 July | 14 | 35 | 49 |
| 2022 June | 12 | 22 | 34 |
| 2022 May | 72 | 35 | 107 |
| 2022 April | 41 | 36 | 77 |
| 2022 March | 41 | 59 | 100 |
| 2022 February | 19 | 27 | 46 |
| 2022 January | 22 | 44 | 66 |
| 2021 December | 16 | 40 | 56 |
| 2021 November | 23 | 48 | 71 |
| 2021 October | 33 | 42 | 75 |
| 2021 September | 18 | 54 | 72 |
| 2021 August | 23 | 27 | 50 |
| 2021 July | 20 | 36 | 56 |
| 2021 June | 21 | 41 | 62 |
| 2021 May | 13 | 28 | 41 |
| 2021 April | 29 | 55 | 84 |
| 2021 March | 54 | 27 | 81 |
| 2021 February | 42 | 18 | 60 |
| 2021 January | 22 | 18 | 40 |
| 2020 December | 15 | 17 | 32 |
| 2020 November | 22 | 26 | 48 |
| 2020 October | 19 | 12 | 31 |
| 2020 September | 6 | 13 | 19 |
| 2020 August | 36 | 28 | 64 |
| 2020 July | 12 | 10 | 22 |
| 2020 June | 23 | 23 | 46 |
| 2020 May | 24 | 25 | 49 |
| 2020 April | 21 | 25 | 46 |
| 2020 March | 23 | 15 | 38 |
| 2020 February | 0 | 2 | 2 |
| 2020 January | 0 | 3 | 3 |
| 2019 December | 0 | 15 | 15 |
| 2019 November | 0 | 2 | 2 |
| 2019 September | 0 | 2 | 2 |
| 2019 August | 0 | 3 | 3 |
| 2019 July | 0 | 2 | 2 |
| 2019 June | 0 | 25 | 25 |
| 2019 May | 0 | 29 | 29 |
| 2019 April | 0 | 3 | 3 |
| 2019 March | 0 | 4 | 4 |
| 2018 May | 0 | 3 | 3 |
| 2018 February | 11 | 3 | 14 |
| 2018 January | 14 | 4 | 18 |
| 2017 December | 19 | 8 | 27 |
| 2017 November | 15 | 3 | 18 |
| 2017 October | 12 | 2 | 14 |
| 2017 September | 18 | 5 | 23 |
| 2017 August | 24 | 7 | 31 |
| 2017 July | 27 | 6 | 33 |
| 2017 June | 29 | 20 | 49 |
| 2017 May | 26 | 4 | 30 |
| 2017 April | 30 | 7 | 37 |
| 2017 March | 41 | 8 | 49 |
| 2017 February | 15 | 10 | 25 |
| 2017 January | 14 | 9 | 23 |
| 2016 December | 29 | 12 | 41 |
| 2016 November | 23 | 5 | 28 |
| 2016 October | 21 | 12 | 33 |
| 2016 September | 26 | 1 | 27 |
| 2016 August | 31 | 7 | 38 |
| 2016 July | 18 | 4 | 22 |
| 2016 June | 9 | 5 | 14 |
| 2016 May | 7 | 0 | 7 |
| 2016 April | 7 | 0 | 7 |
| 2016 March | 4 | 1 | 5 |
| 2016 February | 9 | 1 | 10 |
| 2016 January | 6 | 1 | 7 |
| 2015 December | 12 | 1 | 13 |
| 2015 November | 7 | 0 | 7 |
| 2015 October | 6 | 1 | 7 |
| 2015 September | 6 | 2 | 8 |
| 2015 August | 18 | 6 | 24 |
| 2015 July | 18 | 10 | 28 |
| 2015 June | 24 | 6 | 30 |
| 2015 May | 47 | 2 | 49 |
| 2015 April | 29 | 6 | 35 |
| 2015 March | 23 | 4 | 27 |
| 2015 February | 18 | 6 | 24 |
| 2015 January | 14 | 12 | 26 |
| 2014 December | 27 | 17 | 44 |
| 2014 November | 13 | 6 | 19 |
| 2014 October | 31 | 10 | 41 |
| 2014 September | 22 | 21 | 43 |
| 2014 August | 27 | 18 | 45 |
| 2014 July | 29 | 13 | 42 |
| 2014 June | 21 | 10 | 31 |
| 2014 May | 32 | 9 | 41 |
| 2014 April | 38 | 12 | 50 |
| 2014 March | 38 | 13 | 51 |
| 2014 February | 21 | 10 | 31 |
| 2014 January | 30 | 15 | 45 |
| 2013 December | 30 | 11 | 41 |
| 2013 November | 28 | 16 | 44 |
| 2013 October | 30 | 13 | 43 |
| 2013 September | 29 | 15 | 44 |
| 2013 August | 24 | 12 | 36 |
| 2013 July | 20 | 28 | 48 |
| 2013 June | 17 | 13 | 30 |
| 2013 May | 14 | 5 | 19 |
| 2013 April | 19 | 19 | 38 |
| 2013 March | 28 | 14 | 42 |
| 2013 February | 11 | 12 | 23 |
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