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Lymphomatoid Papulosis in Children: Report of 9 Cases and Review of the Literature
Papulosis linfomatoide en la infancia: presentación de 9 casos y revisión de la literatura
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Aguayo-Leiva, L. Ríos-Buceta, P. Jaén-Olasolo" "autores" => array:3 [ 0 => array:2 [ "nombre" => "I.R." "apellidos" => "Aguayo-Leiva" ] 1 => array:2 [ "nombre" => "L." "apellidos" => "Ríos-Buceta" ] 2 => array:2 [ "nombre" => "P." "apellidos" => "Jaén-Olasolo" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219010706983?idApp=UINPBA000044" "url" => "/15782190/0000010100000008/v1_201304241529/S1578219010706983/v1_201304241529/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Lymphomatoid Papulosis in Children: Report of 9 Cases and Review of the Literature" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "693" "paginaFinal" => "701" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "A. Martorell-Calatayud, A. Hernández-Martín, I. Colmenero, S. Vañó-Galván, C. López-Obregón, A. Armand, M. Gambra Arzoz, A. Torrelo" "autores" => array:8 [ 0 => array:4 [ "nombre" => "A." "apellidos" => "Martorell-Calatayud" "email" => array:1 [ 0 => "antmarto@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "A." "apellidos" => "Hernández-Martín" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "I." "apellidos" => "Colmenero" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "S." 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"apellidos" => "Torrelo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital Infantil Niño Jesús, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Hospital Infantil Niño Jesús, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Pediatría, Hospital Infantil Niño Jesús, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Papulosis linfomatoide en la infancia: presentación de 9 casos y revisión de la literatura" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2010-01-07" "fechaAceptado" => "2010-03-11" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec84797" "palabras" => array:3 [ 0 => "Cutaneous T-cell lymphoma" 1 => "Lymphomatoid papulosis" 2 => "Childhood" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84796" "palabras" => array:3 [ 0 => "Linfoma cutáneo de células T" 1 => "Papulosis linfomatoide" 2 => "Infancia" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Lymphomatoid papulosis is a rare CD30+ T-cell lymphoproliferative disease with an excellent prognosis. It is usually seen in adults and is rare in children. The clinical and pathologic manifestations and the risk of progression to other types of lymphoma are thus not clearly defined in the pediatric age group.</p> <span class="elsevierStyleSectionTitle">Objective</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To describe the characteristics of lymphomatoid papulosis in a group of children and perform a review of the literature.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A retrospective study was performed of 9 patients under 18 years of age diagnosed with lymphomatoid papulosis and treated in our department between 1995 and 2009</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The study included 7 boys and 2 girls aged between 2 and 17 years. Lesions compatible with pityriasis lichenoides acuta appeared before the lymphomatoid papulosis in 2 cases and afterwards in 1 case. The lymphomatoid papulosis lesions resolved spontaneously, leaving postinflammatory hyperpigmentation (77%) or hypopigmentation (23%). Scarring occurred in 77% of cases. Histologically, all cases showed features compatible with lymphomatoid papulosis type A. Molecular studies showed monoclonality in all 3 cases in which this technique was performed.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Lymphomatoid papulosis is a rare disease in childhood and the manifestations are similar to the adult form. This lymphoproliferative disease, occasionally associated with pityriasis lichenoides acuta, has histological features compatible with a type A or histiocytoid pattern. Progression to other lymphoproliferative disorders during followup is less common in the childhood form than in adults. The frequent association of pityriasis lichenoides acuta and lymphomatoid papulosis observed in our study, and the difficulty distinguishing between these 2 conditions in some cases, suggest that these diseases could be part of a single clinical-pathological spectrum.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">La papulosis linfomatoide es un proceso linfoproliferativo de células T CD30+ poco frecuente y de pronóstico excelente que generalmente afecta a adultos y, en menor medida a niños, por lo que tanto el espectro clínico-patológico como el riesgo de progresión a otro tipo de linfoma en el grupo pediátrico no están bien establecidos.</p> <span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Analizar las características de la papulosis linfomatoide infantil a partir de la descripción de nuevos casos y de la revisión de la literatura.</p> <span class="elsevierStyleSectionTitle">Material y método</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Se realizó un estudio retrospectivo de 9 pacientes menores de 18 años diagnosticados de papulosis linfomatoide atendidos en nuestro servicio entre 1995 y 2009.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Se incluyeron 7 niños y 2 niñas de edades entre 2 y 17 años. Las lesiones de papulosis linfomatoide se vieron precedidas en 2 casos y seguidas en 1 de otras compatibles con pitiriasis liquenoide aguda.</p><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">La resolución de las lesiones fue espontánea, dejando hiperpigmentación (77%) o hipopigmentación postinflamatoria (23%) y cicatrices en el 77% de los casos. Histológicamente todos los casos presentaron el patrón tipo A de papulosis linfomatoide. El estudio molecular mostró monoclonalidad en los 3 casos en los que fue realizado.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">La papulosis linfomatoide infantil es una entidad rara que se manifiesta clínicamente como la forma adulta. Esta enfermedad linfoproliferativa, que ocasionalmente se asocia a pitiriasis liquenoide aguda, muestra hallazgos histológicos compatibles con el patrón histiocitoide o tipo A. El desarrollo de otros procesos linfoproliferativos malignos en el seguimiento posterior es menos frecuente en la papulosis linfomatoide infantil comparado con la variante adulta. La frecuente asociación de pitiriasis liquenoide y de papulosis linfomatoide encontrada en nuestro análisis, así como la dificultad que supone en algunos casos el diferenciar entre ambos procesos, permiten sugerir que ambas patologías podrían formar parte de un espectro clínico-patológico común.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:15 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lymphomatoid papulosis: A continuing selfhealing eruption, clinically benign-histologically malignant" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "W.L. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 12 | 6 | 18 |
| 2024 October | 60 | 54 | 114 |
| 2024 September | 62 | 32 | 94 |
| 2024 August | 78 | 76 | 154 |
| 2024 July | 68 | 36 | 104 |
| 2024 June | 67 | 45 | 112 |
| 2024 May | 58 | 108 | 166 |
| 2024 April | 80 | 106 | 186 |
| 2024 March | 54 | 92 | 146 |
| 2024 February | 42 | 95 | 137 |
| 2024 January | 42 | 98 | 140 |
| 2023 December | 49 | 74 | 123 |
| 2023 November | 59 | 70 | 129 |
| 2023 October | 56 | 37 | 93 |
| 2023 September | 44 | 39 | 83 |
| 2023 August | 32 | 36 | 68 |
| 2023 July | 65 | 83 | 148 |
| 2023 June | 28 | 34 | 62 |
| 2023 May | 37 | 65 | 102 |
| 2023 April | 23 | 32 | 55 |
| 2023 March | 27 | 58 | 85 |
| 2023 February | 20 | 61 | 81 |
| 2023 January | 27 | 50 | 77 |
| 2022 December | 29 | 63 | 92 |
| 2022 November | 18 | 49 | 67 |
| 2022 October | 13 | 31 | 44 |
| 2022 September | 11 | 49 | 60 |
| 2022 August | 14 | 42 | 56 |
| 2022 July | 12 | 39 | 51 |
| 2022 June | 10 | 34 | 44 |
| 2022 May | 17 | 49 | 66 |
| 2022 April | 22 | 45 | 67 |
| 2022 March | 21 | 69 | 90 |
| 2022 February | 21 | 35 | 56 |
| 2022 January | 20 | 44 | 64 |
| 2021 December | 16 | 46 | 62 |
| 2021 November | 29 | 44 | 73 |
| 2021 October | 18 | 47 | 65 |
| 2021 September | 18 | 54 | 72 |
| 2021 August | 27 | 24 | 51 |
| 2021 July | 28 | 44 | 72 |
| 2021 June | 19 | 26 | 45 |
| 2021 May | 21 | 42 | 63 |
| 2021 April | 43 | 48 | 91 |
| 2021 March | 49 | 18 | 67 |
| 2021 February | 40 | 24 | 64 |
| 2021 January | 27 | 20 | 47 |
| 2020 December | 13 | 24 | 37 |
| 2020 November | 25 | 16 | 41 |
| 2020 October | 32 | 10 | 42 |
| 2020 September | 23 | 18 | 41 |
| 2020 August | 28 | 22 | 50 |
| 2020 July | 18 | 13 | 31 |
| 2020 June | 25 | 28 | 53 |
| 2020 May | 28 | 31 | 59 |
| 2020 April | 17 | 17 | 34 |
| 2020 March | 27 | 17 | 44 |
| 2020 February | 1 | 2 | 3 |
| 2020 January | 0 | 3 | 3 |
| 2019 December | 0 | 10 | 10 |
| 2019 November | 1 | 4 | 5 |
| 2019 October | 0 | 1 | 1 |
| 2019 September | 0 | 4 | 4 |
| 2019 August | 0 | 5 | 5 |
| 2019 July | 0 | 6 | 6 |
| 2019 June | 0 | 5 | 5 |
| 2019 May | 0 | 38 | 38 |
| 2019 March | 0 | 12 | 12 |
| 2018 March | 4 | 1 | 5 |
| 2018 February | 29 | 4 | 33 |
| 2018 January | 14 | 3 | 17 |
| 2017 December | 35 | 10 | 45 |
| 2017 November | 17 | 1 | 18 |
| 2017 October | 20 | 4 | 24 |
| 2017 September | 18 | 5 | 23 |
| 2017 August | 32 | 6 | 38 |
| 2017 July | 20 | 5 | 25 |
| 2017 June | 14 | 5 | 19 |
| 2017 May | 12 | 8 | 20 |
| 2017 April | 16 | 19 | 35 |
| 2017 March | 18 | 8 | 26 |
| 2017 February | 20 | 4 | 24 |
| 2017 January | 13 | 4 | 17 |
| 2016 December | 28 | 4 | 32 |
| 2016 November | 25 | 4 | 29 |
| 2016 October | 23 | 16 | 39 |
| 2016 September | 28 | 7 | 35 |
| 2016 August | 36 | 9 | 45 |
| 2016 July | 20 | 4 | 24 |
| 2016 June | 12 | 9 | 21 |
| 2016 May | 6 | 7 | 13 |
| 2016 April | 3 | 3 | 6 |
| 2016 March | 4 | 7 | 11 |
| 2016 February | 7 | 1 | 8 |
| 2016 January | 10 | 1 | 11 |
| 2015 December | 11 | 1 | 12 |
| 2015 November | 6 | 1 | 7 |
| 2015 October | 6 | 3 | 9 |
| 2015 September | 2 | 4 | 6 |
| 2015 August | 14 | 4 | 18 |
| 2015 July | 22 | 29 | 51 |
| 2015 June | 13 | 5 | 18 |
| 2015 May | 54 | 10 | 64 |
| 2015 April | 29 | 6 | 35 |
| 2015 March | 32 | 9 | 41 |
| 2015 February | 21 | 11 | 32 |
| 2015 January | 17 | 17 | 34 |
| 2014 December | 14 | 20 | 34 |
| 2014 November | 16 | 13 | 29 |
| 2014 October | 28 | 15 | 43 |
| 2014 September | 25 | 13 | 38 |
| 2014 August | 35 | 16 | 51 |
| 2014 July | 28 | 12 | 40 |
| 2014 June | 34 | 10 | 44 |
| 2014 May | 45 | 13 | 58 |
| 2014 April | 35 | 10 | 45 |
| 2014 March | 29 | 14 | 43 |
| 2014 February | 30 | 20 | 50 |
| 2014 January | 26 | 18 | 44 |
| 2013 December | 22 | 18 | 40 |
| 2013 November | 29 | 20 | 49 |
| 2013 October | 35 | 19 | 54 |
| 2013 September | 33 | 20 | 53 |
| 2013 August | 23 | 26 | 49 |
| 2013 July | 33 | 37 | 70 |
| 2013 June | 24 | 21 | 45 |
| 2013 May | 29 | 26 | 55 |
| 2013 April | 27 | 22 | 49 |
| 2013 March | 27 | 24 | 51 |
| 2013 February | 13 | 23 | 36 |
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