Controversies in dermatology
Studies of Methyl Aminolevulinate Photodynamic Therapy for Actinic Keratosis
Terapia fotodinámica: estudios con metilaminolevulinato en queratosis actínicas
M. Fernández-Guarino
, A. Harto, P. Jaén
Corresponding author
Servicio de Dermatología, Hospital Universitario Ramón y Cajal, Universidad de Alcalá de Henares, Madrid, Spain
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"apellidos" => "Fernández-Guarino" "email" => array:1 [ 0 => "montsefdez@msn.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Harto" ] 2 => array:2 [ "nombre" => "P." "apellidos" => "Jaén" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Dermatología, Hospital Universitario Ramón y Cajal, Universidad de Alcalá de Henares, Madrid, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Terapia fotodinámica: estudios con metilaminolevulinato en queratosis actínicas" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2009-09-02" "fechaAceptado" => "2009-12-17" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec84745" "palabras" => array:2 [ 0 => "Photodynamic therapy" 1 => "Methyl aminolevulinate" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84744" "palabras" => array:2 [ 0 => "Terapia fotodinámica" 1 => "Metilaminolevulinato" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Photodynamic therapy (PDT) for the treatment of actinic keratosis has been shown to be effective and safe in large clinical trials published in the last 5 years. However, evidence has since emerged that raises questions or that introduces new issues, such as the management of field cancerization, fluorescence diagnosis and results in transplant recipients. There also remains a need for more studies comparing PDT to additional treatments. We review the literature on these new topics in PDT.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">La terapia fotodinámica (TFD) se ha mostrado eficaz y segura en el tratamiento de las queratosis actínicas (QA) en importantes estudios en los últimos 5 años. Sin embargo, desde entonces, se han publicado varios trabajos con alguna evidencia contradictoria o añadiendo nuevos aspectos de esta terapia para su discusión, como es el tratamiento del campo de cancerización, el diagnóstico de fluorescencia, los resultados en pacientes trasplantados o la ausencia de estudios comparativos con otros tratamientos. En este trabajo revisamos estos nuevos aspectos de la TFD.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:49 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Photodynamic therapy using topical methyl 5-aminolaevulinate compared with cryotherapy for for actinic keratosis: a prospective, randomized study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R.M. Szeimies" 1 => "S. Barrer" 2 => "S. Radakovic-Fijan" 3 => "A. Tanew" 4 => "P.G. Calzavara-Pinton" 5 => "C. Zane" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2002" "volumen" => "47" "paginaInicial" => "258" "paginaFinal" => "262" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12140473" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A comparison of photodynamic therapy using topical methyl aminolaevulinate (Metvix<span class="elsevierStyleSup">®</span>) with single cycle cryotherapy in patients with actinic keratosis: a prospective, randomized study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M. Freeman" 1 => "C. Vinciullo" 2 => "D. Francis" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Dermatol Treat" "fecha" => "2003" "volumen" => "14" "paginaInicial" => "99" "paginaFinal" => "106" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Photodynamic therapy with topical methyl aminolevulinate (Metvix<span class="elsevierStyleSup">®</span>) is effective and safe in the treatment of actinic keratosis: results of a prospective randomized trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D.M. Pariser" 1 => "N.J. Lowe" 2 => "D.M. Stewar" 3 => "M.T. Jarratt" 4 => "A.W. Lucky" 5 => "R.J. Pariser" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1067/mjd.2003.49" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2003" "volumen" => "48" "paginaInicial" => "227" "paginaFinal" => "232" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12582393" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A randomized multicenter study to compare two treatment regimens of topical methyl aminolevulinate (Metvix<span class="elsevierStyleSup">®</span>) in actinic keratosis on the face and scalp" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M. Tarstedt" 1 => "I. Rosdahl" 2 => "B. Berne" 3 => "K. Svanberg" 4 => "A.M. Wennberg" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1080/00015550510032887" "Revista" => array:6 [ "tituloSerie" => "Acta Derm Venereol" "fecha" => "2005" "volumen" => "85" "paginaInicial" => "424" "paginaFinal" => "428" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16159735" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intraindividual right-left comparison of topical methyl-aminolevulinate-photodynamic therapy (MAL-PDT) and cryotherapy in subject with actinic keratosis: a multicentre, randomized controlled study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Morton" 1 => "S. Campbell" 2 => "G. Gupta" 3 => "S. Keohane" 4 => "J. Lear" 5 => "I. Zaki" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2006.07470.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2006" "volumen" => "155" "paginaInicial" => "1029" "paginaFinal" => "1036" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17034536" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pharmacology of protoporphyrin IX in nude mice after application of ALA and ALA esters" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. Moan" 1 => "L.W. Ma" 2 => "A. Juzeniene" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/ijc.10802" "Revista" => array:6 [ "tituloSerie" => "Int J Cancer" "fecha" => "2003" "volumen" => "103" "paginaInicial" => "132" "paginaFinal" => "135" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12455066" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Microscopic localization of protoporphyrin IX in normal mouse skin after topical application of 5-aminolaevulinic acid or methyl-aminolaevulinic acid" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "H. Bruijn" 1 => "C. Meijers" 2 => "A. van der Ploeg-van den Heuvel" 3 => "H.J. Sterenborg" 4 => "D.J. Robinson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Photochem Photobiol" "fecha" => "2008" "volumen" => "92" "paginaInicial" => "91" "paginaFinal" => "97" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Randomized, double blind, prospective study to compare topical 5-aminolaevulinic acid methylester with topical 5-aminolaevulinic acid photodynamic therapy for extensive scalp actinic keratosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "F.J. Moloney" 1 => "P. Collins" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2007.07946.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2007" "volumen" => "157" "paginaInicial" => "87" "paginaFinal" => "91" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17501954" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Photodynamic therapy induces less pain in patients treated with methylamino levulinate compared to aminolevulinic acid" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. Kasche" 1 => "S. Luderschmidt" 2 => "J. Ring" 3 => "R. Hein" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Drugs Dermatol" "fecha" => "2006" "volumen" => "5" "paginaInicial" => "353" "paginaFinal" => "356" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16673803" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Terapia fotodinámica en dermatología" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "Y. Gilaberte" 1 => "C. Serra-Guillén" 2 => "M.E. de las Heras" 3 => "R. Ruiz-Rodríguez" 4 => "M. Fernández-Lorente" 5 => "C. Benvenuto-Andrade" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2006" "volumen" => "97" "paginaInicial" => "83" "paginaFinal" => "102" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16595110" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Photodynamic therapy for actinic keratosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Kalisiak" 1 => "J. Rao" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.det.2006.09.006" "Revista" => array:6 [ "tituloSerie" => "Dermatol Clin" "fecha" => "2007" "volumen" => "25" "paginaInicial" => "15" "paginaFinal" => "23" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17126738" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effective photodynamic therapy of actinic keratoses on the head and face with a novel, self-adhesive 5-aminolaevulinic acid patch" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Hauschild" 1 => "G. Popp" 2 => "E. Stockfleth" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1600-0625.2008.00770.x" "Revista" => array:6 [ "tituloSerie" => "Exp Dermatol" "fecha" => "2009" "volumen" => "18" "paginaInicial" => "116" "paginaFinal" => "121" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18643849" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Optimization of photodynamic therapy with a novel self-adhesive 5-aminolaevulinic acid path: results of two randomized controlled phase II studies" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Hauschild" 1 => "E. Stockfleth" 2 => "G. Popp" 3 => "F. Borrosch" 4 => "H. Brüning" 5 => "R. Dominicus" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2009.09040.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2009" "volumen" => "160" "paginaInicial" => "1066" "paginaFinal" => "1074" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19222455" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Szeimies RM, Stokleft E, Popp G, Borrosh F. Long-term follow-up of photodynamic therapy with a self-adhesive 5-aminolaevulinic acid patch: 12 months data. Br J Dermatol 2009. In press." ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Laser mediated photodynamic therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M. Alexiades-Armenakas" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.clindermatol.2005.10.027" "Revista" => array:6 [ "tituloSerie" => "Clin Dermatol" "fecha" => "2006" "volumen" => "24" "paginaInicial" => "16" "paginaFinal" => "25" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16427502" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Topical 5-aminolaevulinic acid photodynamic therapy for cutaneous lesions: outcome and comparison of light sources" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "C. Clark" 1 => "A. Bryden" 2 => "R. Dawe" 3 => "H. Moseley" 4 => "J. Ferguson" 5 => "S.H. Ibbotson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Photodermatol Photoimmunol Photomed" "fecha" => "2003" "volumen" => "19" "paginaInicial" => "134" "paginaFinal" => "141" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12914598" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Topical methyl aminolevulinate photodynamic therapy using red light emitting diode light for multiple actinic keratosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R.M. Szeimies" 1 => "R.T. Matheson" 2 => "A. Steven" 3 => "A.C. Bhatia" 4 => "Y. Frambach" 5 => "W. Klövekorn" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1524-4725.2009.01096.x" "Revista" => array:6 [ "tituloSerie" => "Dermatol Surg" "fecha" => "2009" "volumen" => "35" "paginaInicial" => "586" "paginaFinal" => "592" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19309347" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Split-face study using two different light sources for topical PDT of actinic keratosis: non inferiority of the LED system" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "P. Babilas" 1 => "R. Travnik" 2 => "A. Werner" 3 => "M. Landthaler" 4 => "R.M. Szeimies" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Dtch Dermatol Guest" "fecha" => "2008" "volumen" => "6" "paginaInicial" => "25" "paginaFinal" => "33" ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effectiveness of different light sources for 5-aminolaevulinic acid photodynamic therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Juzeniene" 1 => "P. Juzenas" 2 => "L.W. Ma" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s10103-004-0314-x" "Revista" => array:6 [ "tituloSerie" => "Lasers Med Sci" "fecha" => "2004" "volumen" => "19" "paginaInicial" => "139" "paginaFinal" => "149" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15503248" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Variable pulsed light is less painful than light emitting diodes for topical photodynamic therapy of actinic keratosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P. Babilas" 1 => "R. Knobler" 2 => "S. Hummel" 3 => "C. Gottschaller" 4 => "T. Maisch" 5 => "M. Koller" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2007.07959.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2007" "volumen" => "157" "paginaInicial" => "111" "paginaFinal" => "117" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17542980" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Photodynamic photorejuvenation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R. Ruiz-Rodríguez" 1 => "T. Sanz-Sánchez" 2 => "S. Córdoba" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Dermatol Surg" "fecha" => "2002" "volumen" => "28" "paginaInicial" => "742" "paginaFinal" => "744" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12174070" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Continuous activation of PpIX by daylight is as effective and less painful than conventional photodynamic therapy for actinic keratosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "S.R. Wiegell" 1 => "M. Haedersdal" 2 => "P.A. Philipsen" 3 => "P. Eriksen" 4 => "C.D. Enk" 5 => "H.C. Wulf" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2008.08450.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2008" "volumen" => "158" "paginaInicial" => "740" "paginaFinal" => "746" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18294318" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Photodynamic therapy of actinic keratosis with 8% and 16% methyl aminolaevulinate and home-based daylight exposure" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S.R. Wiegell" 1 => "M. Haedersdal" 2 => "P. Eriksen" 3 => "H.C. Wulf" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2009.09119.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2009" "volumen" => "160" "paginaInicial" => "1308" "paginaFinal" => "1314" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19416257" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ambulatory photodynamic therapy, a new concept in delivering photodynamic therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "H. Moseley" 1 => "J.W. Allen" 2 => "S. Ibbotson" 3 => "A. Lesar" 4 => "A. McNeill" 5 => "M.A. Camacho-López" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2006.07145.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2006" "volumen" => "154" "paginaInicial" => "747" "paginaFinal" => "750" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16536822" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "An open pilot study of ambulatory photodynamic therapy using a wearable low-irradiance organic light-emitting diode light source in the treatment of nonmelanoma skin cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S.K. Attili" 1 => "A. Lesar" 2 => "A. Mc Neill" 3 => "M. Camacho-López" 4 => "H. Moseley" 5 => "S. Ibbotson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2009.09096.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2009" "volumen" => "161" "paginaInicial" => "170" "paginaFinal" => "173" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19302071" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Short incubation with methyl aminolevulinate photodynamic therapy of actinic keratosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "L. Braathen" 1 => "B.E. Paredes" 2 => "O. Sakleka" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Eur Acad Dermatol" "fecha" => "2008" "volumen" => "23" "paginaInicial" => "550" "paginaFinal" => "555" ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multicenter intraindividual randomized trial of topical methyl aminolevulinate-photodynamic therapy vs cryotherapy for multiple actinic keratosis on the extremities" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R. Kaufmann" 1 => "L. Spelman" 2 => "W. Weightman" 3 => "J. Reifenberger" 4 => "R.M. Szeimies" 5 => "E. Verhaeghe" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2008.08488.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2008" "volumen" => "158" "paginaInicial" => "994" "paginaFinal" => "999" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18341663" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Estudio retrospectivo, descriptivo y observacional del tratamiento de múltiples queratosis actínicas con metilaminolevulínico y luz roja" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M. Fernández-Guarino" 1 => "A. Harto" 2 => "M. Sánchez-Ronco" 3 => "B. Pérez-García" 4 => "A. Marquet" 5 => "P. Jaén" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Actas Dermosifiliog" "fecha" => "2008" "volumen" => "99" "paginaInicial" => "779" "paginaFinal" => "787" ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Short incubation PDT versus 5-fluorouracil in treating actinic keratosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S. Smit" 1 => "D. Piacquiadio" 2 => "V. Morhenn" 3 => "D. Atkin" 4 => "R. Fitzpatrick" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Drugs Dermatol" "fecha" => "2003" "volumen" => "2" "paginaInicial" => "629" "paginaFinal" => "635" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14711141" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Update on actinic keratosis in clinical trial experience with imiquimod" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "C. Ferrándiz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2007.08270.x" "Revista" => array:7 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2007" "volumen" => "157" "numero" => "Suppl 2" "paginaInicial" => "32" "paginaFinal" => "33" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18067629" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib31" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Guidelines for the management of actinic keratosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D. Becker" 1 => "J.M. Mac Gregor" 2 => "B.R. Hushes" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2006.07692.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2007" "volumen" => "156" "paginaInicial" => "222" "paginaFinal" => "230" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17223860" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib32" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Guidelines for the management of actinic keratosis: developed by the Guideline Subcommittee of the European Dermatology Forum" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "E. Stockfleth" 1 => "H. Kerl" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur J Dermatol" "fecha" => "2006" "volumen" => "16" "paginaInicial" => "599" "paginaFinal" => "606" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17229598" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib33" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Photodynamic therapy for actinic keratoses: survey of patient perceptions of treatment satisfaction and outcomes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "E.P. Tierney" 1 => "M.J. Eide" 2 => "G. Jacobsen" 3 => "D. Ozoq" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1080/14764170802056117" "Revista" => array:6 [ "tituloSerie" => "J Cosmet Laser Ther" "fecha" => "2008" "volumen" => "10" "paginaInicial" => "81" "paginaFinal" => "83" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18569260" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib34" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Complicaciones en la terapia fotodinámica" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M. Huerta Brogeras" 1 => "A. Romero Mate" 2 => "O. Nieto Perea" 3 => "J.M. Borbujo Martínez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Piel" "fecha" => "2007" "volumen" => "22" "paginaInicial" => "309" "paginaFinal" => "313" ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib35" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of post-transplant premalignant skin disease: a randomized intrapatient comparative study of 5-fluorouracil cream and topical photodynamic therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C.M. Perrett" 1 => "J.M. Mc Gregor" 2 => "J. Warwick" 3 => "P. Karran" 4 => "I.M. Leigh" 5 => "C.M. Proby" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2006.07616.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2007" "volumen" => "156" "paginaInicial" => "320" "paginaFinal" => "328" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17223873" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib36" "etiqueta" => "36." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cold water and pauses in illumination reduces pain during photodynamic therapy: a randomized clinical study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S.R. Wiegell" 1 => "M. Haedersdal" 2 => "H.C. Wulf" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2340/00015555-0568" "Revista" => array:6 [ "tituloSerie" => "Acta Derm Venereol" "fecha" => "2009" "volumen" => "89" "paginaInicial" => "145" "paginaFinal" => "149" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19325998" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib37" "etiqueta" => "37." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparative study between cold air analgesia and supraorbital and supratrochlear nerve block for the management of pain during photodynamic therapy for actinic keratoses of theof frontotemporal zone" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Serra-Guillén" 1 => "L. Hueso" 2 => "E. Nagore" 3 => "M. Vila" 4 => "B. Llombart" 5 => "C. Requena Caballero" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2009.09184.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2009" "volumen" => "161" "paginaInicial" => "353" "paginaFinal" => "356" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19438468" "web" => "Medline" ] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib38" "etiqueta" => "38." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nerve blocks enable adecuate pain relief during photodynamic therapy of field cancerization of the forehead and scalp" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "C.B. Halldin" 1 => "J. Paoli" 2 => "C. Sandberg" 3 => "H. Gozalez" 4 => "A.M. Wennberg" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2008.09024.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2009" "volumen" => "160" "paginaInicial" => "795" "paginaFinal" => "800" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19210497" "web" => "Medline" ] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib39" "etiqueta" => "39." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A randomized controlled trial of topical photodynamic therapy with methyl aminolaevulinate in the treatment of actinic keratoses in transplant recipients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Dagrieva" 1 => "B.M. Prinz" 2 => "J. Hafner" 3 => "R. Dummer" 4 => "G. Burg" 5 => "U. Binswnger" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2004.06054.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2004" "volumen" => "151" "paginaInicial" => "196" "paginaFinal" => "200" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15270891" "web" => "Medline" ] ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib40" "etiqueta" => "40." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Topical photodynamic therapy of actinic keratosis in renal transplant recipients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Piaserico" 1 => "A. Belloni Fortina" 2 => "P. Rigotti" 3 => "B. Rossi" 4 => "N. Baldan" 5 => "M. Alaibac" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.transproceed.2007.05.040" "Revista" => array:6 [ "tituloSerie" => "Transplant Proc" "fecha" => "2007" "volumen" => "39" "paginaInicial" => "1847" "paginaFinal" => "1850" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17692630" "web" => "Medline" ] ] ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib41" "etiqueta" => "41." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Photodynamic therapy does not prevent cutaneous squamous carcinoma in organ transplant recipients: results of a randomized controlled trial" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "Y.G. De Graaf" 1 => "C. Kennedy" 2 => "R. Wolterbeek" 3 => "A.F. Collen" 4 => "R. Willemze" 5 => "J.N. Bouwes Bavinck" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/sj.jid.5700098" "Revista" => array:6 [ "tituloSerie" => "J Invest Dermatol" "fecha" => "2006" "volumen" => "126" "paginaInicial" => "569" "paginaFinal" => "574" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16374480" "web" => "Medline" ] ] ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib42" "etiqueta" => "42." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Photodynamic therapy with methyl aminolevulinate for prevention of new skin lesions in transplant recipients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A.M. Wennberg" 1 => "B. Stenquist" 2 => "E. Stockfleth" 3 => "S. Keohane" 4 => "J.T. Lear" 5 => "G. Jemec" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/TP.0b013e318180731e" "Revista" => array:6 [ "tituloSerie" => "Transplantation" "fecha" => "2008" "volumen" => "86" "paginaInicial" => "423" "paginaFinal" => "429" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18698246" "web" => "Medline" ] ] ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib43" "etiqueta" => "43." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Field cancerization in oral stratified squamous epithelium" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D.P. Slaughter" 1 => "H.W. Southwick" 2 => "W. Smejkal" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "1953" "volumen" => "6" "paginaInicial" => "963" "paginaFinal" => "968" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/13094644" "web" => "Medline" ] ] ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bib44" "etiqueta" => "44." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Management of field change in actinic keratosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M. Vatve" 1 => "J.P. Ortonne" 2 => "Birch-Marchin" 3 => "G. Gupta" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2007.08268.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2007" "volumen" => "157" "paginaInicial" => "21" "paginaFinal" => "24" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18067627" "web" => "Medline" ] ] ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bib45" "etiqueta" => "45." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of actinic keratosis with sequential use of photodynamic therapy and imiquimod" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M. Shaffelburg" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Drugs Dermatol" "fecha" => "2009" "volumen" => "8" "paginaInicial" => "35" "paginaFinal" => "39" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19180894" "web" => "Medline" ] ] ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bib46" "etiqueta" => "46." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Photodynamic therapy of actinic keratosis at varying fluence rates: assessment of photobleaching, pain and primary clinical outcome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.B. Ericson" 1 => "C. Sandberg" 2 => "B. Stenquist" 3 => "F. Gudmundson" 4 => "M. Karlsson" 5 => "A.M. Ros" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2004.06211.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2004" "volumen" => "151" "paginaInicial" => "1204" "paginaFinal" => "1212" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15606516" "web" => "Medline" ] ] ] ] ] ] ] ] 46 => array:3 [ "identificador" => "bib47" "etiqueta" => "47." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pharmacoeconomics considerations in treating actinic keratosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.W. Neidecker" 1 => "M.L. Davis-Ajami" 2 => "R. Balkrishnan" 3 => "S.R. Feldman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2165/00019053-200927060-00002" "Revista" => array:6 [ "tituloSerie" => "Pharmacoeconomics" "fecha" => "2009" "volumen" => "27" "paginaInicial" => "451" "paginaFinal" => "464" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19640009" "web" => "Medline" ] ] ] ] ] ] ] ] 47 => array:3 [ "identificador" => "bib48" "etiqueta" => "48." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Economic evaluation of methyl aminolaevulinic acid-based photodynamic therapy in the management of actinic keratosis and basal cell carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "K. Caekelbergh" 1 => "L. Annemans" 2 => "J. Lambert" 3 => "R. Roelandts" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2006.07483.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2006" "volumen" => "155" "paginaInicial" => "784" "paginaFinal" => "790" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16965429" "web" => "Medline" ] ] ] ] ] ] ] ] 48 => array:3 [ "identificador" => "bib49" "etiqueta" => "49." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "An economic evaluation of topical treatments for actinic keratosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D. Muston" 1 => "A. Downs" 2 => "V. Rives" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Dermatol Treat" "fecha" => "2009" "volumen" => "1" "paginaInicial" => "1" "paginaFinal" => "10" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010100000004/v1_201304241521/S1578219010706417/v1_201304241521/en/main.assets" "Apartado" => array:4 [ "identificador" => "6176" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Controversies in Dermatology" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010100000004/v1_201304241521/S1578219010706417/v1_201304241521/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219010706417?idApp=UINPBA000044" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 6 | 7 | 13 |
| 2024 October | 57 | 43 | 100 |
| 2024 September | 66 | 36 | 102 |
| 2024 August | 102 | 79 | 181 |
| 2024 July | 82 | 39 | 121 |
| 2024 June | 82 | 24 | 106 |
| 2024 May | 74 | 28 | 102 |
| 2024 April | 48 | 30 | 78 |
| 2024 March | 49 | 34 | 83 |
| 2024 February | 45 | 34 | 79 |
| 2024 January | 45 | 33 | 78 |
| 2023 December | 44 | 33 | 77 |
| 2023 November | 80 | 33 | 113 |
| 2023 October | 50 | 40 | 90 |
| 2023 September | 35 | 34 | 69 |
| 2023 August | 38 | 16 | 54 |
| 2023 July | 36 | 49 | 85 |
| 2023 June | 39 | 23 | 62 |
| 2023 May | 32 | 25 | 57 |
| 2023 April | 33 | 27 | 60 |
| 2023 March | 27 | 19 | 46 |
| 2023 February | 35 | 17 | 52 |
| 2023 January | 53 | 38 | 91 |
| 2022 December | 45 | 53 | 98 |
| 2022 November | 19 | 27 | 46 |
| 2022 October | 22 | 28 | 50 |
| 2022 September | 24 | 38 | 62 |
| 2022 August | 14 | 30 | 44 |
| 2022 July | 15 | 33 | 48 |
| 2022 June | 14 | 15 | 29 |
| 2022 May | 42 | 38 | 80 |
| 2022 April | 27 | 48 | 75 |
| 2022 March | 26 | 46 | 72 |
| 2022 February | 32 | 26 | 58 |
| 2022 January | 27 | 30 | 57 |
| 2021 December | 19 | 39 | 58 |
| 2021 November | 21 | 54 | 75 |
| 2021 October | 24 | 54 | 78 |
| 2021 September | 19 | 44 | 63 |
| 2021 August | 25 | 32 | 57 |
| 2021 July | 9 | 34 | 43 |
| 2021 June | 17 | 23 | 40 |
| 2021 May | 20 | 28 | 48 |
| 2021 April | 42 | 47 | 89 |
| 2021 March | 48 | 18 | 66 |
| 2021 February | 38 | 27 | 65 |
| 2021 January | 28 | 18 | 46 |
| 2020 December | 35 | 11 | 46 |
| 2020 November | 23 | 25 | 48 |
| 2020 October | 16 | 13 | 29 |
| 2020 September | 17 | 14 | 31 |
| 2020 August | 20 | 14 | 34 |
| 2020 July | 16 | 10 | 26 |
| 2020 June | 20 | 21 | 41 |
| 2020 May | 23 | 16 | 39 |
| 2020 April | 21 | 19 | 40 |
| 2020 March | 21 | 26 | 47 |
| 2020 February | 3 | 1 | 4 |
| 2020 January | 0 | 3 | 3 |
| 2019 December | 0 | 8 | 8 |
| 2019 November | 0 | 2 | 2 |
| 2019 October | 0 | 2 | 2 |
| 2019 August | 0 | 2 | 2 |
| 2019 July | 0 | 3 | 3 |
| 2019 June | 0 | 2 | 2 |
| 2019 May | 0 | 41 | 41 |
| 2019 April | 0 | 2 | 2 |
| 2019 March | 0 | 4 | 4 |
| 2019 February | 0 | 5 | 5 |
| 2018 March | 0 | 1 | 1 |
| 2018 February | 10 | 3 | 13 |
| 2018 January | 14 | 6 | 20 |
| 2017 December | 18 | 8 | 26 |
| 2017 November | 20 | 2 | 22 |
| 2017 October | 12 | 5 | 17 |
| 2017 September | 18 | 7 | 25 |
| 2017 August | 18 | 6 | 24 |
| 2017 July | 15 | 8 | 23 |
| 2017 June | 35 | 12 | 47 |
| 2017 May | 37 | 12 | 49 |
| 2017 April | 34 | 15 | 49 |
| 2017 March | 30 | 12 | 42 |
| 2017 February | 17 | 5 | 22 |
| 2017 January | 17 | 8 | 25 |
| 2016 December | 27 | 4 | 31 |
| 2016 November | 29 | 17 | 46 |
| 2016 October | 14 | 9 | 23 |
| 2016 September | 24 | 4 | 28 |
| 2016 August | 28 | 8 | 36 |
| 2016 July | 21 | 7 | 28 |
| 2016 June | 10 | 12 | 22 |
| 2016 May | 7 | 0 | 7 |
| 2016 April | 6 | 1 | 7 |
| 2016 March | 3 | 6 | 9 |
| 2016 February | 7 | 1 | 8 |
| 2016 January | 5 | 4 | 9 |
| 2015 December | 11 | 0 | 11 |
| 2015 November | 7 | 1 | 8 |
| 2015 October | 9 | 2 | 11 |
| 2015 September | 9 | 4 | 13 |
| 2015 August | 12 | 3 | 15 |
| 2015 July | 17 | 4 | 21 |
| 2015 June | 27 | 4 | 31 |
| 2015 May | 39 | 12 | 51 |
| 2015 April | 31 | 9 | 40 |
| 2015 March | 21 | 4 | 25 |
| 2015 February | 28 | 10 | 38 |
| 2015 January | 14 | 7 | 21 |
| 2014 December | 35 | 13 | 48 |
| 2014 November | 23 | 10 | 33 |
| 2014 October | 28 | 12 | 40 |
| 2014 September | 22 | 12 | 34 |
| 2014 August | 36 | 11 | 47 |
| 2014 July | 39 | 16 | 55 |
| 2014 June | 41 | 9 | 50 |
| 2014 May | 34 | 12 | 46 |
| 2014 April | 45 | 9 | 54 |
| 2014 March | 45 | 19 | 64 |
| 2014 February | 41 | 15 | 56 |
| 2014 January | 23 | 14 | 37 |
| 2013 December | 29 | 12 | 41 |
| 2013 November | 21 | 24 | 45 |
| 2013 October | 33 | 17 | 50 |
| 2013 September | 25 | 23 | 48 |
| 2013 August | 24 | 34 | 58 |
| 2013 July | 39 | 18 | 57 |
| 2013 June | 30 | 22 | 52 |
| 2013 May | 27 | 25 | 52 |
| 2013 April | 37 | 29 | 66 |
| 2013 March | 51 | 31 | 82 |
| 2013 February | 18 | 16 | 34 |
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