Case Report
Leishmaniasis and Rheumatoid Nodulosis in a Patient With HIV Infection
Leishmaniasis y Nodulosis Reumatoide en Paciente con Infección por el Virus de la Inmunodeficiencia Humana
Read
5316
Timeswas read the article
2310
Total PDF
3006
Total HTML
Share statistics
array:23 [ "pii" => "S157821901070603X" "issn" => "15782190" "doi" => "10.1016/S1578-2190(10)70603-X" "estado" => "S300" "fechaPublicacion" => "2010-03-01" "aid" => "70603" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "copyrightAnyo" => "2010" "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Actas Dermosifiliogr. 2010;101:164-7" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2047 "formatos" => array:3 [ "EPUB" => 44 "HTML" => 1314 "PDF" => 689 ] ] "itemSiguiente" => array:18 [ "pii" => "S1578219010706041" "issn" => "15782190" "doi" => "10.1016/S1578-2190(10)70604-1" "estado" => "S300" "fechaPublicacion" => "2010-03-01" "aid" => "70604" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Actas Dermosifiliogr. 2010;101:168-72" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2740 "formatos" => array:3 [ "EPUB" => 37 "HTML" => 1605 "PDF" => 1098 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case Report</span>" "titulo" => "Galli-Galli Disease Presenting as Lichenoid Papules in the Flexures" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "168" "paginaFinal" => "172" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Presentación de Enfermedad de Galli-Galli Como Pápulas Liquenoides Flexurales" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "I. García-Salces, C. Hörndler, L. Requena" "autores" => array:3 [ 0 => array:2 [ "nombre" => "I." "apellidos" => "García-Salces" ] 1 => array:2 [ "nombre" => "C." "apellidos" => "Hörndler" ] 2 => array:2 [ "nombre" => "L." "apellidos" => "Requena" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219010706041?idApp=UINPBA000044" "url" => "/15782190/0000010100000002/v1_201304241515/S1578219010706041/v1_201304241515/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1578219010706028" "issn" => "15782190" "doi" => "10.1016/S1578-2190(10)70602-8" "estado" => "S300" "fechaPublicacion" => "2010-03-01" "aid" => "70602" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2010;101:156-63" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2306 "formatos" => array:3 [ "EPUB" => 47 "HTML" => 1401 "PDF" => 858 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Adverse Reactions During Biological Therapy for Psoriasis: Results of a Survey of the Spanish Psoriasis Group" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "156" "paginaFinal" => "163" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Efectos Adversos Observados Durante la Terapia Biológica en la Psoriasis. Resultados de una Encuesta al Grupo Español de Psoriasis" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M. Sánchez-Regaña, E. Dilmé, Ll. Puig, X. Bordas, J.M. Carrascos, M. Ferran, P. Herranz, M. García-Bustinduy, J.L. López Estebaranz, M. Alsina, M.A. Rodríguez, M. Ribera, E. Fernández-López, J.C. Moreno, I. Belinchón Romero, D. Vidal" "autores" => array:16 [ 0 => array:2 [ "nombre" => "M." "apellidos" => "Sánchez-Regaña" ] 1 => array:2 [ "nombre" => "E." "apellidos" => "Dilmé" ] 2 => array:2 [ "nombre" => "Ll." "apellidos" => "Puig" ] 3 => array:2 [ "nombre" => "X." "apellidos" => "Bordas" ] 4 => array:2 [ "nombre" => "J.M." "apellidos" => "Carrascos" ] 5 => array:2 [ "nombre" => "M." "apellidos" => "Ferran" ] 6 => array:2 [ "nombre" => "P." "apellidos" => "Herranz" ] 7 => array:2 [ "nombre" => "M." "apellidos" => "García-Bustinduy" ] 8 => array:2 [ "nombre" => "J.L." "apellidos" => "López Estebaranz" ] 9 => array:2 [ "nombre" => "M." "apellidos" => "Alsina" ] 10 => array:2 [ "nombre" => "M.A." "apellidos" => "Rodríguez" ] 11 => array:2 [ "nombre" => "M." "apellidos" => "Ribera" ] 12 => array:2 [ "nombre" => "E." "apellidos" => "Fernández-López" ] 13 => array:2 [ "nombre" => "J.C." "apellidos" => "Moreno" ] 14 => array:2 [ "nombre" => "I." "apellidos" => "Belinchón Romero" ] 15 => array:2 [ "nombre" => "D." "apellidos" => "Vidal" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219010706028?idApp=UINPBA000044" "url" => "/15782190/0000010100000002/v1_201304241515/S1578219010706028/v1_201304241515/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case Report</span>" "titulo" => "Leishmaniasis and Rheumatoid Nodulosis in a Patient With HIV Infection" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "164" "paginaFinal" => "167" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "I. García-Río, E. Daudén, M. Ballestero-Díez, J. Fraga, A. García-Díez" "autores" => array:5 [ 0 => array:4 [ "nombre" => "I." "apellidos" => "García-Río" "email" => array:1 [ 0 => "irene@aedv.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "E." "apellidos" => "Daudén" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 2 => array:3 [ "nombre" => "M." "apellidos" => "Ballestero-Díez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 3 => array:3 [ "nombre" => "J." "apellidos" => "Fraga" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 4 => array:3 [ "nombre" => "A." "apellidos" => "García-Díez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Departamento de Dermatología, Hospital Universitario de la Princesa, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Departamento de Anatomía Patológica, Hospital Universitario de la Princesa, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Leishmaniasis y Nodulosis Reumatoide en Paciente con Infección por el Virus de la Inmunodeficiencia Humana" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2008-12-16" "fechaAceptado" => "2009-01-26" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec84679" "palabras" => array:4 [ 0 => "Leishmaniasis" 1 => "Rheumatoid nodulosis" 2 => "Human immunodeficiency virus" 3 => "Acquired immune deficiency syndrome" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84678" "palabras" => array:4 [ 0 => "Leishmaniasis" 1 => "Nodulosis reumatoide" 2 => "Virus de la inmunodeficiencia humana" 3 => "Sida" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">We describe the case of a 44-year-old homosexual man diagnosed with HIV infection and visceral leishmaniasis. He presented nodules on the dorsum of the hands. Histological study of one of the nodules revealed necrobiotic palisading granulomas with abundant Leishmania amastigotes within the histiocytes and in the adjacent extracellular space.</p><p class="elsevierStyleSimplePara elsevierViewall">Tissue and peripheral blood cultures were positive for Leishmania infantum, zymodeme MON-24. A biopsy of healthy skin did not reveal the presence of Leishmania. A diagnosis of rheumatoid nodulosis with Leishmania was made and treatment was started with intravenous liposomal amphotericin, leading to slight improvement.</p><p class="elsevierStyleSimplePara elsevierViewall">We believe that the presence of the parasite within the nodules was the result of its dissemination during visceral leishmaniasis in an immunocompromised patient with HIV infection, and that the Leishmania did not have an etiological role in the appearance of the nodules. We present the first case of the association between Leishmania and rheumatoid nodulosis.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Describimos el caso de un paciente varón de 44 años, homosexual, infectado por el virus de la inmunodeficiencia humana (VIH) y diagnosticado de leishmaniasis visceral. Clínicamente presentaba unos nódulos en el dorso de las manos. El estudio histológico de uno de ellos mostraba granulomas necrobióticos en empalizada y abundantes amastigotes de Leishmania dentro de los histiocitos y extracelularmente en la proximidad.</p><p class="elsevierStyleSimplePara elsevierViewall">Los cultivos tisulares y de sangre periférica fueron positivos para Leishmania infantum, con el análisis isoenzimático zymodema 24. Una biopsia de piel sana no reveló la presencia de Leishmania. El diagnóstico fue de nodulosis reumatoide con Leishmania, y se inició tratamiento con anfotericina liposomal intravenosa con leve mejoría.</p><p class="elsevierStyleSimplePara elsevierViewall">Consideramos que la presencia del parásito en los nódulos fue producida por la diseminación durante la leishmaniasis visceral, en el contexto de un paciente inmunosuprimido, como en una infección por el VIH, y no tiene un papel etiológico en su origen. Es decir, no pensamos que los parásitos hayan producido los nódulos. Presentamos el primer caso de asociación entre leishmania y nodulosis reumatoide.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:16 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Leishmaniasis or AIDS?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A. De la Loma" 1 => "J. Alvar" 2 => "E. Martínez Galiano" 3 => "J. Blázquez" 4 => "A. Alcalá Muñoz" 5 => "R. Nájera" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Trans R Soc Trop Med Hyg" "fecha" => "1985" "volumen" => "79" "paginaInicial" => "421" "paginaFinal" => "422" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4035745" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Leishmaniasis and AIDS co-infection: the Spanish example" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J. Alvar" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Parasitology Today" "fecha" => "1994" "volumen" => "10" "paginaInicial" => "160" "paginaFinal" => "163" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15275487" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Leishmaniasis cutánea" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D. García-Almagro" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2005" "volumen" => "96" "paginaInicial" => "1" "paginaFinal" => "24" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16476327" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Rheumatoid nodulosis: an unusual variant of rheumatoid disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.H. Ginsberg" 1 => "H.K. Genant" 2 => "T.F. Yu" 3 => "D.J. McCarty" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "1975" "volumen" => "18" "paginaInicial" => "49" "paginaFinal" => "58" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1078777" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Disseminated-to-skin kala-azar and the acquired immunodeficiency syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M. Yebra" 1 => "J. Segovia" 2 => "L. Manzano" 3 => "J.A. Vargas" 4 => "L. Bernaldo de Quirós" 5 => "J. Alvar" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Intern Med" "fecha" => "1988" "volumen" => "108" "paginaInicial" => "490" "paginaFinal" => "491" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3341692" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Leishmaniasis presenting as a psoriasiform eruption in AIDS" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F.A. Rubio" 1 => "G. Robayna" 2 => "P. Herranz" 3 => "E. Torres" 4 => "J.M. Peña" 5 => "F. Contreras" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "1997" "volumen" => "136" "paginaInicial" => "792" "paginaFinal" => "794" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9205523" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Leishmaniasis presenting as a dermatomyositis-like eruption in AIDS" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E. Daudén" 1 => "P.F. Peñas" 2 => "L. Ríos" 3 => "M. Jiménez" 4 => "J. Fraga" 5 => "J. Alvar" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "1996" "volumen" => "35" "paginaInicial" => "316" "paginaFinal" => "319" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8698915" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Visceral leishmaniasis involving lung and a cutaneous Kaposi's sarcoma lesion" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Romeu" 1 => "F. Milla" 2 => "M. Batlle" 3 => "G. Sirera" 4 => "C. Ferrandiz" 5 => "A. Carreres" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "AIDS" "fecha" => "1991" "volumen" => "5" "paginaInicial" => "1272" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1786161" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous and systemic leishmaniasis with a herpes virus infection in an AIDS patient" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. España" 1 => "J.M. Hermida" 2 => "P. Montilla" 3 => "L. Buzón" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rev Clin Esp" "fecha" => "1990" "volumen" => "187" "paginaInicial" => "437" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2091147" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Leishmania infection occurring in herpes zoster lesions in an HIV-positive patient" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J. Barrio" 1 => "M. Lecona" 2 => "J. Cosin" 3 => "F.J. Olalquiaga" 4 => "J.M. Hernanz" 5 => "J. Soto" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "1996" "volumen" => "134" "paginaInicial" => "164" "paginaFinal" => "166" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8745907" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Presence of Leishmania organisms in specific and non-specific skin lesions in HIV-infected individuals with visceral leishmaniasis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "R.J. Bosch" 1 => "A.B. Rodrigo" 2 => "P. Sánchez" 3 => "M.V. de Gálvez" 4 => "E. Herrera" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int J Dermatol" "fecha" => "2002" "volumen" => "41" "paginaInicial" => "670" "paginaFinal" => "675" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12390190" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Unusual cutaneous lesions in two patients with visceral leishmaniasis and HIV infection" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R. Colebunders" 1 => "K. Depraetere" 2 => "T. Verstraeten" 3 => "J. Lambert" 4 => "E. Hauben" 5 => "E. Van Marck" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "1999" "volumen" => "41" "paginaInicial" => "847" "paginaFinal" => "850" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10534667" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The presence and significance of leishmania in mucocutaneous biopsies from HIV patients with visceral leishmaniasis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "E. Herrera" 1 => "J. Bosch" 2 => "F. Fernández" 3 => "M. de Troya" 4 => "P. Sanchez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Eur J Dermatol" "fecha" => "1996" "volumen" => "6" "paginaInicial" => "501" "paginaFinal" => "504" ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Visceral leishmaniasis with cutaneous lesions in a patient infected with human immunodeficiency virus" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Ara" 1 => "C. Maillo" 2 => "G. Peón" 3 => "A. Clavel" 4 => "J. Cuesta" 5 => "M.P. Grasa" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "1998" "volumen" => "139" "paginaInicial" => "114" "paginaFinal" => "117" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9764161" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Relapse of cutaneous leishmaniasis in a patient with an infected subcutaneous rheumatoid nodule" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "D.A. Vardy" 1 => "A. Cohen" 2 => "L. Kachko" 3 => "A. Zvulunov" 4 => "S. Frankenburg" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "1999" "volumen" => "141" "paginaInicial" => "914" "paginaFinal" => "917" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10583179" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Leishmaniasis con fenómeno de eliminación transepidémica. Descripción de dos casos en pacientes con sida" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.L. Espinel" 1 => "J.A. Martín-Jaramillo" 2 => "B. Meléndez-Guerrero" 3 => "S. Vázquez-Navarrete" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2004" "volumen" => "95" "paginaInicial" => "390" "paginaFinal" => "393" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010100000002/v1_201304241515/S157821901070603X/v1_201304241515/en/main.assets" "Apartado" => array:4 [ "identificador" => "6253" "tipo" => "SECCION" "fr" => array:2 [ "titulo" => "Case reports" "idiomaDefecto" => true ] "idiomaDefecto" => "fr" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010100000002/v1_201304241515/S157821901070603X/v1_201304241515/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157821901070603X?idApp=UINPBA000044" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 3 | 4 | 7 |
| 2024 October | 58 | 39 | 97 |
| 2024 September | 44 | 26 | 70 |
| 2024 August | 82 | 60 | 142 |
| 2024 July | 44 | 34 | 78 |
| 2024 June | 66 | 23 | 89 |
| 2024 May | 58 | 28 | 86 |
| 2024 April | 49 | 32 | 81 |
| 2024 March | 52 | 34 | 86 |
| 2024 February | 50 | 42 | 92 |
| 2024 January | 44 | 32 | 76 |
| 2023 December | 50 | 29 | 79 |
| 2023 November | 33 | 29 | 62 |
| 2023 October | 42 | 39 | 81 |
| 2023 September | 35 | 24 | 59 |
| 2023 August | 24 | 11 | 35 |
| 2023 July | 35 | 37 | 72 |
| 2023 June | 35 | 20 | 55 |
| 2023 May | 30 | 26 | 56 |
| 2023 April | 30 | 20 | 50 |
| 2023 March | 18 | 22 | 40 |
| 2023 February | 24 | 21 | 45 |
| 2023 January | 22 | 26 | 48 |
| 2022 December | 24 | 35 | 59 |
| 2022 November | 14 | 24 | 38 |
| 2022 October | 13 | 21 | 34 |
| 2022 September | 17 | 48 | 65 |
| 2022 August | 28 | 29 | 57 |
| 2022 July | 27 | 31 | 58 |
| 2022 June | 27 | 33 | 60 |
| 2022 May | 19 | 35 | 54 |
| 2022 April | 25 | 31 | 56 |
| 2022 March | 27 | 56 | 83 |
| 2022 February | 18 | 25 | 43 |
| 2022 January | 21 | 31 | 52 |
| 2021 December | 13 | 42 | 55 |
| 2021 November | 27 | 52 | 79 |
| 2021 October | 19 | 51 | 70 |
| 2021 September | 18 | 47 | 65 |
| 2021 August | 19 | 46 | 65 |
| 2021 July | 21 | 34 | 55 |
| 2021 June | 27 | 31 | 58 |
| 2021 May | 18 | 34 | 52 |
| 2021 April | 16 | 20 | 36 |
| 2021 March | 46 | 23 | 69 |
| 2021 February | 43 | 19 | 62 |
| 2021 January | 21 | 17 | 38 |
| 2020 December | 31 | 14 | 45 |
| 2020 November | 20 | 18 | 38 |
| 2020 October | 24 | 8 | 32 |
| 2020 September | 26 | 10 | 36 |
| 2020 August | 17 | 18 | 35 |
| 2020 July | 16 | 12 | 28 |
| 2020 June | 17 | 19 | 36 |
| 2020 May | 25 | 13 | 38 |
| 2020 April | 13 | 17 | 30 |
| 2020 March | 27 | 16 | 43 |
| 2020 February | 0 | 3 | 3 |
| 2020 January | 0 | 10 | 10 |
| 2019 December | 0 | 7 | 7 |
| 2019 November | 0 | 4 | 4 |
| 2019 September | 0 | 3 | 3 |
| 2019 July | 0 | 6 | 6 |
| 2019 June | 0 | 2 | 2 |
| 2019 May | 1 | 39 | 40 |
| 2019 April | 0 | 1 | 1 |
| 2019 March | 0 | 5 | 5 |
| 2019 February | 0 | 3 | 3 |
| 2019 January | 1 | 0 | 1 |
| 2018 December | 0 | 3 | 3 |
| 2018 October | 0 | 2 | 2 |
| 2018 September | 1 | 0 | 1 |
| 2018 February | 10 | 2 | 12 |
| 2018 January | 10 | 6 | 16 |
| 2017 December | 14 | 6 | 20 |
| 2017 November | 10 | 4 | 14 |
| 2017 October | 16 | 5 | 21 |
| 2017 September | 13 | 6 | 19 |
| 2017 August | 25 | 9 | 34 |
| 2017 July | 17 | 10 | 27 |
| 2017 June | 32 | 8 | 40 |
| 2017 May | 31 | 5 | 36 |
| 2017 April | 38 | 11 | 49 |
| 2017 March | 24 | 23 | 47 |
| 2017 February | 17 | 14 | 31 |
| 2017 January | 18 | 9 | 27 |
| 2016 December | 28 | 10 | 38 |
| 2016 November | 22 | 11 | 33 |
| 2016 October | 15 | 19 | 34 |
| 2016 September | 26 | 4 | 30 |
| 2016 August | 29 | 4 | 33 |
| 2016 July | 18 | 6 | 24 |
| 2016 June | 9 | 8 | 17 |
| 2016 May | 6 | 4 | 10 |
| 2016 April | 3 | 4 | 7 |
| 2016 March | 5 | 9 | 14 |
| 2016 February | 6 | 3 | 9 |
| 2016 January | 9 | 0 | 9 |
| 2015 December | 8 | 2 | 10 |
| 2015 November | 14 | 1 | 15 |
| 2015 October | 4 | 1 | 5 |
| 2015 September | 6 | 1 | 7 |
| 2015 August | 10 | 4 | 14 |
| 2015 July | 21 | 4 | 25 |
| 2015 June | 22 | 9 | 31 |
| 2015 May | 58 | 19 | 77 |
| 2015 April | 30 | 10 | 40 |
| 2015 March | 28 | 15 | 43 |
| 2015 February | 27 | 14 | 41 |
| 2015 January | 19 | 8 | 27 |
| 2014 December | 20 | 14 | 34 |
| 2014 November | 18 | 13 | 31 |
| 2014 October | 31 | 12 | 43 |
| 2014 September | 17 | 10 | 27 |
| 2014 August | 28 | 10 | 38 |
| 2014 July | 30 | 16 | 46 |
| 2014 June | 30 | 9 | 39 |
| 2014 May | 42 | 12 | 54 |
| 2014 April | 28 | 11 | 39 |
| 2014 March | 46 | 22 | 68 |
| 2014 February | 19 | 7 | 26 |
| 2014 January | 35 | 11 | 46 |
| 2013 December | 37 | 9 | 46 |
| 2013 November | 25 | 18 | 43 |
| 2013 October | 27 | 14 | 41 |
| 2013 September | 28 | 16 | 44 |
| 2013 August | 20 | 19 | 39 |
| 2013 July | 38 | 24 | 62 |
| 2013 June | 28 | 14 | 42 |
| 2013 May | 15 | 11 | 26 |
| 2013 April | 20 | 17 | 37 |
| 2013 March | 21 | 15 | 36 |
| 2013 February | 10 | 12 | 22 |
Show all
