Controversies in Dermatology
Primary Cutaneous CD30+ Lymphoproliferative Disorders
Síndrome linfoproliferativo CD30+ cutáneo primario
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"apellidos" => "Calzado-Villarreal" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 1 => array:3 [ "nombre" => "I." "apellidos" => "Polo-Rodríguez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 2 => array:4 [ "nombre" => "P.L." "apellidos" => "Ortiz-Romero" "email" => array:1 [ 0 => "portiz.hdoc@salud.madrid.org" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Unidad de Dermatología, Hospital Universitario Fundación de Alcorcón, Alcorcón, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital Universitario 12 de Octubre, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Síndrome linfoproliferativo CD30<span class="elsevierStyleSup">+</span> cutáneo primario" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2009-02-13" "fechaAceptado" => "2009-07-09" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec84696" "palabras" => array:4 [ 0 => "Cutaneous lymphomas" 1 => "CD30<span class="elsevierStyleSup">+</span> lymphoproliferative disorders" 2 => "Lymphomatoid papulosis" 3 => "CD30+ anaplastic large-cell lymphomas" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84697" "palabras" => array:4 [ 0 => "Linfomas cutáneos" 1 => "Síndrome linfoproliferativo CD30<span class="elsevierStyleSup">+</span>" 2 => "Papulosis linfomatoide" 3 => "Linfoma anaplástico de célula grande CD30<span class="elsevierStyleSup">+</span>" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">CD30<span class="elsevierStyleSup">+</span> lymphoproliferative disorders are the most common group of cutaneous T-cell lymphomas after mycosis fungoides and its subtypes. This group includes lymphomatoid papulosis and CD30<span class="elsevierStyleSup">+</span> anaplastic large-cell lymphoma; these 2 entities are the extremes of a spectrum with numerous intermediate varieties in which it is not possible to establish a clear diagnosis based on clinical and histopathologic criteria. CD30<span class="elsevierStyleSup">+</span> lymphoproliferative disorders must be differentiated from other lymphoproliferative diseases with CD30<span class="elsevierStyleSup">+</span> cells in the tumor infiltrates, such as mycosis fungoides or Hodgkin disease, and also from other inflammatory conditions or nonhematological neoplasms that can include this cell type, such as pityriasis lichenoides et varioliformis acuta or certain mesenchymal tumors (CD30<span class="elsevierStyleSup">+</span> pseudolymphomas). In contrast to their systemic homologues, which arise in the lymph nodes, CD30<span class="elsevierStyleSup">+</span> lymphoproliferative disorders generally have a good prognosis. It is very important to exclude the presence of a lymphoma of systemic origin with extralymphatic spread, as the prognosis and treatment are different.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">El segundo grupo más frecuente de linfomas cutáneos de células T son los síndromes linfoproliferativos (SLP) CD30+, por detrás del grupo de la micosis fungoide (MF) y sus variantes. Estos engloban la papulosis linfomatoide y los linfomas anaplásicos de células grandes CD30+, polos de un espectro que dejan en su zona central casos intermedios, donde no se puede establecer con seguridad un diagnóstico en base a criterios clínicos e histopatológicos.</p><p class="elsevierStyleSimplePara elsevierViewall">Los SLP CD30+ deben diferenciarse de otros procesos linfoproliferativos que pueden presentar células CD30+ en sus infiltrados tumorales, como la propia MF o la enfermedad de Hodgkin, y también de otras entidades inflamatorias o neoplasias no hematológicas que presenten estas células, como es el caso de la pitiriasis liquenoide y varioliforme aguda o determinados tumores mesenquimales («pseudolinfomas CD30+»).</p><p class="elsevierStyleSimplePara elsevierViewall">En general, el pronóstico de estos SLP CD30+ es favorable, lo que les diferencia de sus homólogos sistémicos, de origen ganglionar. Resulta muy importante descartar la presencia de linfoma de origen sistémico con afectación extraganglionar, pues el pronóstico y el tratamiento serán diferentes.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:29 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "CD30 (Ki-1) molecule: a new cytokine receptor of the tumor necrosis factor receptor superfamily as a tool for diagnosis and immunotherapy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "B. Falini" 1 => "S. Pileri" 2 => "G. Pizzolo" 3 => "H. Dürkop" 4 => "L. Flenghi" 5 => "F. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 3 | 12 | 15 |
| 2024 October | 65 | 54 | 119 |
| 2024 September | 59 | 27 | 86 |
| 2024 August | 85 | 61 | 146 |
| 2024 July | 66 | 34 | 100 |
| 2024 June | 72 | 44 | 116 |
| 2024 May | 52 | 39 | 91 |
| 2024 April | 55 | 31 | 86 |
| 2024 March | 47 | 34 | 81 |
| 2024 February | 56 | 41 | 97 |
| 2024 January | 45 | 42 | 87 |
| 2023 December | 53 | 36 | 89 |
| 2023 November | 45 | 26 | 71 |
| 2023 October | 46 | 30 | 76 |
| 2023 September | 47 | 27 | 74 |
| 2023 August | 23 | 25 | 48 |
| 2023 July | 36 | 57 | 93 |
| 2023 June | 49 | 28 | 77 |
| 2023 May | 45 | 36 | 81 |
| 2023 April | 46 | 24 | 70 |
| 2023 March | 29 | 38 | 67 |
| 2023 February | 33 | 28 | 61 |
| 2023 January | 30 | 34 | 64 |
| 2022 December | 38 | 42 | 80 |
| 2022 November | 13 | 27 | 40 |
| 2022 October | 26 | 19 | 45 |
| 2022 September | 25 | 36 | 61 |
| 2022 August | 21 | 42 | 63 |
| 2022 July | 15 | 38 | 53 |
| 2022 June | 15 | 21 | 36 |
| 2022 May | 28 | 46 | 74 |
| 2022 April | 32 | 36 | 68 |
| 2022 March | 43 | 68 | 111 |
| 2022 February | 27 | 40 | 67 |
| 2022 January | 24 | 40 | 64 |
| 2021 December | 27 | 47 | 74 |
| 2021 November | 29 | 51 | 80 |
| 2021 October | 32 | 52 | 84 |
| 2021 September | 25 | 48 | 73 |
| 2021 August | 19 | 51 | 70 |
| 2021 July | 13 | 33 | 46 |
| 2021 June | 45 | 48 | 93 |
| 2021 May | 29 | 38 | 67 |
| 2021 April | 80 | 31 | 111 |
| 2021 March | 83 | 27 | 110 |
| 2021 February | 56 | 33 | 89 |
| 2021 January | 25 | 17 | 42 |
| 2020 December | 39 | 16 | 55 |
| 2020 November | 24 | 19 | 43 |
| 2020 October | 34 | 15 | 49 |
| 2020 September | 29 | 10 | 39 |
| 2020 August | 27 | 31 | 58 |
| 2020 July | 23 | 23 | 46 |
| 2020 June | 29 | 25 | 54 |
| 2020 May | 31 | 26 | 57 |
| 2020 April | 25 | 24 | 49 |
| 2020 March | 29 | 31 | 60 |
| 2020 February | 3 | 7 | 10 |
| 2020 January | 0 | 17 | 17 |
| 2019 December | 0 | 13 | 13 |
| 2019 November | 0 | 1 | 1 |
| 2019 October | 0 | 5 | 5 |
| 2019 September | 0 | 17 | 17 |
| 2019 August | 0 | 6 | 6 |
| 2019 July | 0 | 11 | 11 |
| 2019 June | 0 | 7 | 7 |
| 2019 May | 0 | 51 | 51 |
| 2019 April | 0 | 25 | 25 |
| 2019 March | 1 | 6 | 7 |
| 2019 February | 1 | 7 | 8 |
| 2019 January | 1 | 1 | 2 |
| 2018 December | 1 | 4 | 5 |
| 2018 November | 11 | 7 | 18 |
| 2018 October | 9 | 0 | 9 |
| 2018 September | 1 | 0 | 1 |
| 2018 May | 0 | 1 | 1 |
| 2018 April | 0 | 2 | 2 |
| 2018 March | 3 | 2 | 5 |
| 2018 February | 17 | 12 | 29 |
| 2018 January | 18 | 12 | 30 |
| 2017 December | 25 | 9 | 34 |
| 2017 November | 22 | 4 | 26 |
| 2017 October | 25 | 5 | 30 |
| 2017 September | 25 | 13 | 38 |
| 2017 August | 23 | 15 | 38 |
| 2017 July | 19 | 9 | 28 |
| 2017 June | 34 | 14 | 48 |
| 2017 May | 23 | 11 | 34 |
| 2017 April | 34 | 4 | 38 |
| 2017 March | 27 | 24 | 51 |
| 2017 February | 24 | 10 | 34 |
| 2017 January | 29 | 5 | 34 |
| 2016 December | 52 | 12 | 64 |
| 2016 November | 40 | 6 | 46 |
| 2016 October | 32 | 20 | 52 |
| 2016 September | 43 | 9 | 52 |
| 2016 August | 64 | 7 | 71 |
| 2016 July | 38 | 8 | 46 |
| 2016 June | 12 | 7 | 19 |
| 2016 May | 7 | 5 | 12 |
| 2016 April | 5 | 25 | 30 |
| 2016 March | 18 | 1 | 19 |
| 2016 February | 14 | 9 | 23 |
| 2016 January | 13 | 11 | 24 |
| 2015 December | 17 | 2 | 19 |
| 2015 November | 17 | 11 | 28 |
| 2015 October | 7 | 9 | 16 |
| 2015 September | 9 | 7 | 16 |
| 2015 August | 14 | 1 | 15 |
| 2015 July | 49 | 7 | 56 |
| 2015 June | 34 | 8 | 42 |
| 2015 May | 89 | 13 | 102 |
| 2015 April | 55 | 21 | 76 |
| 2015 March | 47 | 24 | 71 |
| 2015 February | 36 | 18 | 54 |
| 2015 January | 38 | 16 | 54 |
| 2014 December | 37 | 10 | 47 |
| 2014 November | 16 | 11 | 27 |
| 2014 October | 38 | 18 | 56 |
| 2014 September | 26 | 17 | 43 |
| 2014 August | 41 | 12 | 53 |
| 2014 July | 51 | 17 | 68 |
| 2014 June | 40 | 13 | 53 |
| 2014 May | 50 | 19 | 69 |
| 2014 April | 59 | 14 | 73 |
| 2014 March | 55 | 26 | 81 |
| 2014 February | 47 | 13 | 60 |
| 2014 January | 51 | 19 | 70 |
| 2013 December | 36 | 18 | 54 |
| 2013 November | 31 | 27 | 58 |
| 2013 October | 33 | 28 | 61 |
| 2013 September | 32 | 20 | 52 |
| 2013 August | 18 | 25 | 43 |
| 2013 July | 30 | 30 | 60 |
| 2013 June | 22 | 20 | 42 |
| 2013 May | 18 | 22 | 40 |
| 2013 April | 22 | 33 | 55 |
| 2013 March | 27 | 41 | 68 |
| 2013 February | 17 | 18 | 35 |
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