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Long-term Safety and Efficacy of Etanercept in the Treatment of Psoriasis
Seguridad y eficacia de etanercept a largo plazo en el tratamiento de la psoriasis
V. Zaragoza
, A. Pérez, J.L. Sánchez, V. Oliver, L. Martínez, V. Alegre
Corresponding author
Servicio de Dermatología, Consorcio Hospital General Universitario de Valencia, Valencia, Spain
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Zaragoza, A. Pérez, J.L. Sánchez, V. Oliver, L. Martínez, V. Alegre" "autores" => array:6 [ 0 => array:4 [ "nombre" => "V." "apellidos" => "Zaragoza" "email" => array:1 [ 0 => "vioz@comv.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Pérez" ] 2 => array:2 [ "nombre" => "J.L." "apellidos" => "Sánchez" ] 3 => array:2 [ "nombre" => "V." "apellidos" => "Oliver" ] 4 => array:2 [ "nombre" => "L." "apellidos" => "Martínez" ] 5 => array:2 [ "nombre" => "V." "apellidos" => "Alegre" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Dermatología, Consorcio Hospital General Universitario de Valencia, Valencia, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Seguridad y eficacia de etanercept a largo plazo en el tratamiento de la psoriasis" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2008-10-27" "fechaAceptado" => "2009-07-09" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec84653" "palabras" => array:4 [ 0 => "Etanercept" 1 => "Long-term treatment" 2 => "Safety" 3 => "Efficacy" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84652" "palabras" => array:4 [ 0 => "Etanercept" 1 => "Tratamiento a largo plazo" 2 => "Seguridad" 3 => "Eficacia" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p class="elsevierStyleSimplePara elsevierViewall">Clinical experience has shown that, in patients with psoriasis, suspending treatment with etanercept at week 24, as indicated in the prescribing information, may lead to a rebound effect. Several clinical trials support long-term use of etanercept, which was shown to have a good safety and efficacy profile.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">This was a retrospective, observational study of 43 patients with moderate to severe plaque psoriasis, with and without joint involvement, who received continuous treatment with etanercept for more than 24 weeks.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Etanercept was administered for a mean of 57 weeks. Overall, the Psoriasis Area and Severity Index (PASI) score decreased from a baseline value of 22.5 to 4.3 after treatment. In addition, with continuous treatment, most patients maintained decreases in PASI scores of 50% and even of 75%. Some patients without significant improvement in their PASI score in the first 24 weeks did manage to achieve significant results after prolonged treatment. These outcomes were achieved with a low incidence of adverse effects (reported in 13 patients [30.2%]), which were generally mild.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">We present our clinical experience with long-term etanercept treatment in patients with moderate to severe psoriasis, with and without associated joint involvement. The efficacy and safety profiles were found to be favorable.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p class="elsevierStyleSimplePara elsevierViewall">La experiencia clínica demuestra que la suspensión del tratamiento con etanercept en pacientes con psoriasis en la semana 24, como indica la ficha técnica del fármaco, produce en algunos casos rebrote de la enfermedad. Existen diversos ensayos que avalan el uso de etanercept a largo plazo con un buen perfil de seguridad y eficacia.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Estudio observacional, retrospectivo, en el que se recogió a 43 pacientes con psoriasis en placas de moderada a grave, con y sin artropatía, tratados con etanercept de forma continua durante más de 24 semanas.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">El etanercept se administró durante un tiempo promedio de 57 semanas, y disminuyó el PASI (Psoriasis Area Severity Index) de forma global de un valor basal de 22,5 a 4,3. Además, con el tratamiento continuo, la mayor parte de los pacientes mantuvieron puntuaciones PASI inferiores al 50% o incluso al 75%. Por otra parte, algunos pacientes que no alcanzaron mejorías significativas en su puntuación PASI en las primeras 24 semanas pueden conseguirlo prolongando el tratamiento. Todo ello con una baja incidencia de efectos adversos (13 pacientes [30,2%]) y de características leves.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Exponemos nuestra experiencia clínica con el tratamiento con etanercept a largo plazo en pacientes con psoriasis de moderada a grave, con y sin artropatía asociada, y demostramos un perfil favorable de eficacia y seguridad.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:21 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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Van de Kerkhof" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:3 [ "titulo" => "15th Congress of the European Academy of Dermatology and Venereology" "conferencia" => "Rhodes" "serieFecha" => "2006" ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A 96-week phase 3 study of safety and efficacy of etanercept 50mg twice weekly in patients with psoriasis (poster)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "S. Tyring" 1 => "Y. Poulin" 2 => "R. Langley" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:3 [ "titulo" => "64th Annual Meeting of the American Academy of Dermatology" "conferencia" => "San Francisco (CA)" "serieFecha" => "2006" ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." 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"referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Safety and efficacy of up to 9 years of etanercept therapy in North American patients with rheumatoid arthritis (poster)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M.E. Weinblatt" 1 => "M.C. Genovese" 2 => "L.W. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 5 | 8 | 13 |
| 2024 October | 58 | 43 | 101 |
| 2024 September | 58 | 33 | 91 |
| 2024 August | 76 | 75 | 151 |
| 2024 July | 53 | 38 | 91 |
| 2024 June | 52 | 33 | 85 |
| 2024 May | 41 | 33 | 74 |
| 2024 April | 48 | 25 | 73 |
| 2024 March | 47 | 43 | 90 |
| 2024 February | 40 | 39 | 79 |
| 2024 January | 34 | 54 | 88 |
| 2023 December | 39 | 24 | 63 |
| 2023 November | 41 | 30 | 71 |
| 2023 October | 51 | 34 | 85 |
| 2023 September | 30 | 35 | 65 |
| 2023 August | 28 | 25 | 53 |
| 2023 July | 30 | 50 | 80 |
| 2023 June | 36 | 26 | 62 |
| 2023 May | 30 | 23 | 53 |
| 2023 April | 27 | 19 | 46 |
| 2023 March | 24 | 20 | 44 |
| 2023 February | 18 | 23 | 41 |
| 2023 January | 26 | 33 | 59 |
| 2022 December | 24 | 31 | 55 |
| 2022 November | 12 | 26 | 38 |
| 2022 October | 9 | 14 | 23 |
| 2022 September | 13 | 49 | 62 |
| 2022 August | 17 | 64 | 81 |
| 2022 July | 10 | 59 | 69 |
| 2022 June | 12 | 37 | 49 |
| 2022 May | 14 | 42 | 56 |
| 2022 April | 19 | 32 | 51 |
| 2022 March | 17 | 46 | 63 |
| 2022 February | 15 | 30 | 45 |
| 2022 January | 17 | 37 | 54 |
| 2021 December | 17 | 43 | 60 |
| 2021 November | 29 | 53 | 82 |
| 2021 October | 23 | 51 | 74 |
| 2021 September | 20 | 49 | 69 |
| 2021 August | 20 | 32 | 52 |
| 2021 July | 19 | 18 | 37 |
| 2021 June | 16 | 35 | 51 |
| 2021 May | 16 | 24 | 40 |
| 2021 April | 33 | 53 | 86 |
| 2021 March | 57 | 18 | 75 |
| 2021 February | 61 | 37 | 98 |
| 2021 January | 44 | 23 | 67 |
| 2020 December | 30 | 17 | 47 |
| 2020 November | 22 | 20 | 42 |
| 2020 October | 19 | 11 | 30 |
| 2020 September | 29 | 16 | 45 |
| 2020 August | 21 | 20 | 41 |
| 2020 July | 23 | 17 | 40 |
| 2020 June | 25 | 25 | 50 |
| 2020 May | 16 | 15 | 31 |
| 2020 April | 16 | 16 | 32 |
| 2020 March | 17 | 24 | 41 |
| 2020 February | 1 | 5 | 6 |
| 2020 January | 0 | 4 | 4 |
| 2019 December | 0 | 4 | 4 |
| 2019 November | 0 | 1 | 1 |
| 2019 October | 0 | 3 | 3 |
| 2019 September | 0 | 2 | 2 |
| 2019 August | 0 | 2 | 2 |
| 2019 July | 0 | 6 | 6 |
| 2019 June | 0 | 17 | 17 |
| 2019 May | 0 | 53 | 53 |
| 2019 March | 0 | 2 | 2 |
| 2019 February | 0 | 3 | 3 |
| 2018 March | 0 | 1 | 1 |
| 2018 February | 11 | 4 | 15 |
| 2018 January | 13 | 6 | 19 |
| 2017 December | 15 | 6 | 21 |
| 2017 November | 17 | 3 | 20 |
| 2017 October | 14 | 2 | 16 |
| 2017 September | 27 | 5 | 32 |
| 2017 August | 51 | 7 | 58 |
| 2017 July | 49 | 10 | 59 |
| 2017 June | 65 | 25 | 90 |
| 2017 May | 42 | 11 | 53 |
| 2017 April | 27 | 10 | 37 |
| 2017 March | 29 | 8 | 37 |
| 2017 February | 18 | 4 | 22 |
| 2017 January | 16 | 4 | 20 |
| 2016 December | 26 | 11 | 37 |
| 2016 November | 28 | 6 | 34 |
| 2016 October | 29 | 16 | 45 |
| 2016 September | 34 | 6 | 40 |
| 2016 August | 39 | 7 | 46 |
| 2016 July | 36 | 4 | 40 |
| 2016 June | 6 | 10 | 16 |
| 2016 May | 6 | 4 | 10 |
| 2016 April | 6 | 3 | 9 |
| 2016 March | 5 | 9 | 14 |
| 2016 February | 8 | 3 | 11 |
| 2016 January | 12 | 0 | 12 |
| 2015 December | 15 | 0 | 15 |
| 2015 November | 13 | 3 | 16 |
| 2015 October | 13 | 0 | 13 |
| 2015 September | 10 | 3 | 13 |
| 2015 August | 15 | 3 | 18 |
| 2015 July | 29 | 9 | 38 |
| 2015 June | 42 | 6 | 48 |
| 2015 May | 74 | 13 | 87 |
| 2015 April | 47 | 9 | 56 |
| 2015 March | 46 | 5 | 51 |
| 2015 February | 36 | 9 | 45 |
| 2015 January | 29 | 14 | 43 |
| 2014 December | 21 | 6 | 27 |
| 2014 November | 25 | 10 | 35 |
| 2014 October | 36 | 10 | 46 |
| 2014 September | 30 | 15 | 45 |
| 2014 August | 31 | 11 | 42 |
| 2014 July | 34 | 15 | 49 |
| 2014 June | 34 | 9 | 43 |
| 2014 May | 38 | 13 | 51 |
| 2014 April | 35 | 7 | 42 |
| 2014 March | 59 | 13 | 72 |
| 2014 February | 27 | 14 | 41 |
| 2014 January | 33 | 11 | 44 |
| 2013 December | 46 | 10 | 56 |
| 2013 November | 27 | 16 | 43 |
| 2013 October | 31 | 15 | 46 |
| 2013 September | 24 | 16 | 40 |
| 2013 August | 34 | 28 | 62 |
| 2013 July | 43 | 23 | 66 |
| 2013 June | 25 | 24 | 49 |
| 2013 May | 25 | 20 | 45 |
| 2013 April | 18 | 19 | 37 |
| 2013 March | 28 | 21 | 49 |
| 2013 February | 16 | 11 | 27 |
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