ACTAS 1909-2009
Skin Manifestations of Toxic Syndrome Due to Denatured Rapeseed Oil
Manifestaciones Cutáneas del Síndrome Tóxico por Aceite de Colza Adulterado
E. Fonseca
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Eduardo.Fonseca.Capdevila@sergas.es
Correspondence: Servicio de Dermatología. Complejo Hospitalario Universitario de A Coruña. Xubias de Arriba, 84. 15006 A Coruña. Spain.
Correspondence: Servicio de Dermatología. Complejo Hospitalario Universitario de A Coruña. Xubias de Arriba, 84. 15006 A Coruña. Spain.
Servicio de Dermatología, Complejo Hospitalario Universitario de A Coruña, Spain
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"apellidos" => "Fonseca" "email" => array:1 [ 0 => "Eduardo.Fonseca.Capdevila@sergas.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Dermatología, Complejo Hospitalario Universitario de A Coruña, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Servicio de Dermatología. Complejo Hospitalario Universitario de A Coruña. Xubias de Arriba, 84. 15006 A Coruña. Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Manifestaciones Cutáneas del Síndrome Tóxico por Aceite de Colza Adulterado" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84627" "palabras" => array:11 [ 0 => "toxic syndrome caused by denatured rapeseed oil" 1 => "toxic oil syndrome" 2 => "rash" 3 => "mucinosis" 4 => "toxic mucinosis" 5 => "sclerodermatous syndrome" 6 => "scleroderma" 7 => "eosinophilic fasciitis" 8 => "eosinophilia-myalgia syndrome" 9 => "mast cell" 10 => "mastocytosis" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84628" "palabras" => array:11 [ 0 => "síndrome tóxico por aceite de colza adulterado" 1 => "síndrome tóxico por aceite" 2 => "exantema" 3 => "mucinosis" 4 => "mucinosis tóxica" 5 => "síndrome esclerodermiforme" 6 => "esclerodermia" 7 => "fascitis eosinofílica" 8 => "síndrome mialgiaeosinofilia" 9 => "mastocito" 10 => "mastocitosis" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">This article offered an extensive description of the clinical and pathological features and time-course of the skin manifestations of toxic syndrome caused by denatured rapeseed oil, also known as toxic oil syndrome. This new condition occurred in Spain in 1981 and was due to the ingestion of rapeseed oil intended for industrial use that had been denatured with anilines and subsequently refined and sold fraudulently as olive oil.</p><p class="elsevierStyleSimplePara elsevierViewall">In total, 20 000 cases and 400 deaths were reported. The disease affected mainly women, particularly in the late stages. In the acute phase, the predominant skin manifestations were toxic-allergic rashes reminiscent of allergic urticaria in the dermatopathologic study. In approximately 25% of cases, the patients’ skin subsequently took on an edematous appearance, with pigmentary abnormalities shown to be related to cutaneous mucinosis. Finally, a characteristic sclerodermatous condition would develop that tended to improve spontaneously. The constant presence of mast cells in all biopsies and the development of mastocytosis in several patients pointed to an important role for these cells in the pathogenesis of the condition. This was subsequently confirmed in other sclerodermatous processes.</p><p class="elsevierStyleSimplePara elsevierViewall">In 1989, eosinophilia-myalgia syndrome caused by toxins present in tryptophan food supplements was reported in the United States. This syndrome resembled toxic oil syndrome in many ways and demonstrated that mucinosis and toxic sclerodermatous processes do exist.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">En este artículo se efectuó una amplia descripción clínico-patológica y cronológica de las manifestaciones cutáneas del síndrome tóxico por aceite de colza adulterado o síndrome tóxico por aceite. Esta nueva enfermedad se produjo en España en 1981, debida a la ingesta de aceite de colza destinado a uso industrial, que había sido coloreado con anilinas y posteriormente decolorado de forma fraudulenta y vendido como aceite de oliva.</p><p class="elsevierStyleSimplePara elsevierViewall">En total se produjeron unos 20.000 casos y unos 400 fallecimientos. Existía un predominio por el sexo femenino, sobre todo en la fase tardía. En la fase aguda las manifestaciones cutáneas predominantes fueron exantemas toxoalérgicos, con un patrón dermatopatológico de erupción alérgica urticariforme. Alrededor de un 25% de los casos desarrolló posteriormente un aspecto edematoso de la piel, con trastornos de la pigmentación, que demostró estar relacionado con mucinosis dérmica. Finalmente se produjo un cuadro esclerodermiforme peculiar, que tendió a mejorar de forma espontánea. La presencia constante de mastocitos en todas las biopsias y el desarrollo de mastocitosis en varios pacientes sugirieron un papel importante del mastocito en la patogenia del cuadro, que luego ha sido ratificada en otros procesos esclerodermiformes.</p><p class="elsevierStyleSimplePara elsevierViewall">En 1989 apareció en EE.UU. el síndrome mialgia-eosinofilia, relacionado con sustancias tóxicas presentes en suplementos alimentarios de triptófano y que compartía muchos aspectos con el síndrome tóxico por aceite. Esto corroboró la existencia de mucinosis y cuadros esclerodermiformes de origen tóxico.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:17 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 9 | 10 | 19 |
| 2024 October | 64 | 75 | 139 |
| 2024 September | 66 | 56 | 122 |
| 2024 August | 97 | 77 | 174 |
| 2024 July | 66 | 56 | 122 |
| 2024 June | 70 | 43 | 113 |
| 2024 May | 57 | 31 | 88 |
| 2024 April | 48 | 35 | 83 |
| 2024 March | 41 | 95 | 136 |
| 2024 February | 57 | 48 | 105 |
| 2024 January | 35 | 57 | 92 |
| 2023 December | 29 | 53 | 82 |
| 2023 November | 49 | 46 | 95 |
| 2023 October | 41 | 41 | 82 |
| 2023 September | 29 | 36 | 65 |
| 2023 August | 33 | 20 | 53 |
| 2023 July | 33 | 44 | 77 |
| 2023 June | 18 | 18 | 36 |
| 2023 May | 33 | 28 | 61 |
| 2023 April | 27 | 30 | 57 |
| 2023 March | 29 | 46 | 75 |
| 2023 February | 23 | 19 | 42 |
| 2023 January | 22 | 34 | 56 |
| 2022 December | 30 | 48 | 78 |
| 2022 November | 15 | 38 | 53 |
| 2022 October | 12 | 34 | 46 |
| 2022 September | 18 | 46 | 64 |
| 2022 August | 16 | 39 | 55 |
| 2022 July | 17 | 38 | 55 |
| 2022 June | 20 | 35 | 55 |
| 2022 May | 32 | 45 | 77 |
| 2022 April | 65 | 44 | 109 |
| 2022 March | 50 | 57 | 107 |
| 2022 February | 24 | 31 | 55 |
| 2022 January | 34 | 46 | 80 |
| 2021 December | 25 | 51 | 76 |
| 2021 November | 33 | 42 | 75 |
| 2021 October | 27 | 77 | 104 |
| 2021 September | 24 | 37 | 61 |
| 2021 August | 24 | 42 | 66 |
| 2021 July | 19 | 43 | 62 |
| 2021 June | 27 | 48 | 75 |
| 2021 May | 14 | 22 | 36 |
| 2021 April | 45 | 47 | 92 |
| 2021 March | 34 | 20 | 54 |
| 2021 February | 52 | 28 | 80 |
| 2021 January | 27 | 26 | 53 |
| 2020 December | 27 | 14 | 41 |
| 2020 November | 21 | 22 | 43 |
| 2020 October | 19 | 17 | 36 |
| 2020 September | 29 | 13 | 42 |
| 2020 August | 27 | 28 | 55 |
| 2020 July | 23 | 12 | 35 |
| 2020 June | 37 | 30 | 67 |
| 2020 May | 21 | 15 | 36 |
| 2020 April | 23 | 13 | 36 |
| 2020 March | 25 | 28 | 53 |
| 2020 February | 0 | 4 | 4 |
| 2020 January | 0 | 8 | 8 |
| 2019 December | 0 | 10 | 10 |
| 2019 November | 0 | 3 | 3 |
| 2019 September | 0 | 3 | 3 |
| 2019 August | 0 | 3 | 3 |
| 2019 July | 0 | 7 | 7 |
| 2019 June | 0 | 3 | 3 |
| 2019 May | 1 | 47 | 48 |
| 2019 April | 1 | 22 | 23 |
| 2019 March | 0 | 8 | 8 |
| 2019 February | 0 | 7 | 7 |
| 2019 January | 0 | 1 | 1 |
| 2018 December | 0 | 7 | 7 |
| 2018 June | 0 | 2 | 2 |
| 2018 May | 0 | 6 | 6 |
| 2018 March | 0 | 1 | 1 |
| 2018 February | 7 | 13 | 20 |
| 2018 January | 12 | 7 | 19 |
| 2017 December | 19 | 15 | 34 |
| 2017 November | 10 | 9 | 19 |
| 2017 October | 18 | 8 | 26 |
| 2017 September | 14 | 13 | 27 |
| 2017 August | 8 | 14 | 22 |
| 2017 July | 16 | 6 | 22 |
| 2017 June | 17 | 26 | 43 |
| 2017 May | 11 | 22 | 33 |
| 2017 April | 22 | 7 | 29 |
| 2017 March | 19 | 43 | 62 |
| 2017 February | 17 | 6 | 23 |
| 2017 January | 19 | 18 | 37 |
| 2016 December | 36 | 9 | 45 |
| 2016 November | 26 | 9 | 35 |
| 2016 October | 25 | 16 | 41 |
| 2016 September | 23 | 17 | 40 |
| 2016 August | 22 | 8 | 30 |
| 2016 July | 25 | 13 | 38 |
| 2016 June | 8 | 8 | 16 |
| 2016 May | 8 | 4 | 12 |
| 2016 April | 6 | 10 | 16 |
| 2016 March | 5 | 2 | 7 |
| 2016 February | 12 | 5 | 17 |
| 2016 January | 14 | 2 | 16 |
| 2015 December | 5 | 7 | 12 |
| 2015 November | 14 | 5 | 19 |
| 2015 October | 6 | 0 | 6 |
| 2015 September | 3 | 3 | 6 |
| 2015 August | 8 | 5 | 13 |
| 2015 July | 19 | 5 | 24 |
| 2015 June | 22 | 12 | 34 |
| 2015 May | 45 | 19 | 64 |
| 2015 April | 23 | 10 | 33 |
| 2015 March | 27 | 27 | 54 |
| 2015 February | 18 | 15 | 33 |
| 2015 January | 20 | 18 | 38 |
| 2014 December | 21 | 11 | 32 |
| 2014 November | 14 | 16 | 30 |
| 2014 October | 36 | 21 | 57 |
| 2014 September | 18 | 21 | 39 |
| 2014 August | 31 | 25 | 56 |
| 2014 July | 31 | 21 | 52 |
| 2014 June | 28 | 16 | 44 |
| 2014 May | 34 | 12 | 46 |
| 2014 April | 24 | 8 | 32 |
| 2014 March | 30 | 17 | 47 |
| 2014 February | 13 | 19 | 32 |
| 2014 January | 27 | 16 | 43 |
| 2013 December | 28 | 14 | 42 |
| 2013 November | 22 | 14 | 36 |
| 2013 October | 30 | 17 | 47 |
| 2013 September | 27 | 15 | 42 |
| 2013 August | 17 | 22 | 39 |
| 2013 July | 29 | 27 | 56 |
| 2013 June | 17 | 30 | 47 |
| 2013 May | 9 | 15 | 24 |
| 2013 April | 31 | 22 | 53 |
| 2013 March | 26 | 36 | 62 |
| 2013 February | 19 | 12 | 31 |
| 2013 January | 2 | 2 | 4 |
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