Controversies in dermatology
Problems in Defining Melanoma Regression and Prognostic Implication
Regresión en el Melanoma: Problemas en su Definición e Implicación Pronóstica
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Terencio de las Aguas" "autores" => array:1 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Terencio de las Aguas" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009701702?idApp=UINPBA000044" "url" => "/15782190/0000010000000009/v1_201304241507/S1578219009701702/v1_201304241507/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Controversies in dermatology</span>" "titulo" => "Problems in Defining Melanoma Regression and Prognostic Implication" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "759" "paginaFinal" => "766" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "C. Requena, R. Botella-Estrada, V. Traves, E. Nagore, S. Almenar, C. Guillén" "autores" => array:6 [ 0 => array:4 [ "nombre" => "C." "apellidos" => "Requena" "email" => array:1 [ 0 => "celiareq@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "R." "apellidos" => "Botella-Estrada" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 2 => array:3 [ "nombre" => "V." "apellidos" => "Traves" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 3 => array:3 [ "nombre" => "E." "apellidos" => "Nagore" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 4 => array:3 [ "nombre" => "S." "apellidos" => "Almenar" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 5 => array:3 [ "nombre" => "C." "apellidos" => "Guillén" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Instituto Valenciano de Oncología, Valencia, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Servicio de Dermatología. Instituto Valenciano de Oncología. C/ Profesor Beltrán Báguena, n.° 8. 46009 Valencia, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Regresión en el Melanoma: Problemas en su Definición e Implicación Pronóstica" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2009-03-02" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84593" "palabras" => array:5 [ 0 => "melanoma" 1 => "regression" 2 => "prognosis" 3 => "sentinel lymph node" 4 => "metastasis" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84594" "palabras" => array:5 [ 0 => "melanoma" 1 => "regresión" 2 => "pronóstico" 3 => "ganglio centinela" 4 => "metástasis" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Between 10% and 35% of all melanomas show histological regression. That is, there is an area within the melanoma where the tumor retreats or disappears to be progressively replaced by fibrosis with presence of melanophages and variable degrees of inflammation, and increased vascularity. Such regression is generally considered an indicator of poor prognosis in melanoma, although a number of studies contradict this affirmation.</p><p class="elsevierStyleSimplePara elsevierViewall">In this review, we summarize the leading articles about the influence of regression on melanoma prognosis. The results of these studies are very inconsistent, and so the prognostic significance of regression is somewhat controversial. We believe that some of these differences can be explained by differing criteria for regression and so we propose clear histological criteria to define early and sustained regression.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Entre un 10 y un 35% de todos los melanomas presentan regresión histológica, es decir, un área en el seno del melanoma en el que el tumor disminuye o desaparece y es sustituido progresivamente por fibrosis, con cantidades variables de melanófagos, inflamación y neovascularización. Aunque mayoritariamente se considera la presencia de regresión como un factor de mal pronóstico en el melanoma, existen varios trabajos que contradicen esta idea. En esta revisión resumimos los principales artículos publicados sobre la influencia de la regresión en el pronóstico del melanoma y encontramos resultados muy dispares, de modo que el significado pronóstico de la regresión en el melanoma es, a la vista de los trabajos publicados, cuando menos controvertido. Pensamos que parte de las diferencias encontradas se pueden deber a la disparidad en cuanto a los criterios utilizados para definir la regresión, y por ello proponemos unos criterios histológicos que aclaren los conceptos de regresión temprana y establecida.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:30 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Histological regression in primary cutaneous melanoma: recognition, prevalence and significance" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "K. Blessing" 1 => "K.M. McLaren" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Histopathology" "fecha" => "1992" "volumen" => "20" "paginaInicial" => "315" "paginaFinal" => "322" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1577409" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tumour regression predicts higher risk of sentinel node involvement in thin cutaneous melanomas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J. Oláh" 1 => "R. Gyulai" 2 => "I. Korom" 3 => "E. Varga" 4 => "A. Dobozy" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2003" "volumen" => "149" "paginaInicial" => "662" "paginaFinal" => "663" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14511013" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The prognostic significance of histologic regression in cutaneous melanoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "L. Brogelli" 1 => "U.M. Reali" 2 => "S. Moretti" 3 => "C. Urso" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Melanoma Res" "fecha" => "1992" "volumen" => "2" "paginaInicial" => "87" "paginaFinal" => "91" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1643435" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The significance of inflammation and regression in melanoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M.G. Cook" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Virchows Arch A Pathol Anat Histopathol" "fecha" => "1992" "volumen" => "420" "paginaInicial" => "113" "paginaFinal" => "115" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1549899" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hypothesis: a role for telomere crisis in spontaneous regression of melanoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "B.C. Bastian" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/archderm.139.5.667" "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "2003" "volumen" => "139" "paginaInicial" => "667" "paginaFinal" => "668" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12756110" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immunocytochemical analysis of the cellular infiltrate in primary regressing and non-regressing malignant melanoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "F.J. Tefany" 1 => "R.S. Barnetson" 2 => "G.M. Halliday" 3 => "S.W. McCarthy" 4 => "W.H. McCarthy" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Invest Dermatol" "fecha" => "1991" "volumen" => "97" "paginaInicial" => "197" "paginaFinal" => "202" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1712819" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multi-institutional melanoma lymphatic mapping experience: the prognostic value of sentinel lymph node status in 612 stage I or II melanoma patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.E. Gershenwald" 1 => "W. Thompson" 2 => "P.F. Mansfield" 3 => "J.E. Lee" 4 => "M.I. Colome" 5 => "C.H. Tseng" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/jco.1999.17.3.976" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "1999" "volumen" => "17" "paginaInicial" => "976" "paginaFinal" => "983" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10071292" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prognostic factors analysis of17,600 melanoma patients: validation of the American Joint Committee on Cancer melanoma staging system" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C.M. Balch" 1 => "S.J. Soong" 2 => "J.E. Gershenwald" 3 => "J.F. Thompson" 4 => "D.S. Reintgen" 5 => "N. Cascinelli" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J ClinOncol" "fecha" => "2001" "volumen" => "19" "paginaInicial" => "3622" "paginaFinal" => "3634" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Correlation study between the status of sentinel lymph node(s) and the clinicopathological data of primary melanoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "R. Botella-Estrada" 1 => "E. Nagore" 2 => "L. Hueso" 3 => "J. Giménez" 4 => "S. Almenar" 5 => "C Guillén" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:3 [ "titulo" => "First World Meeting of Interdisciplinary Melanoma/Skin Cancer Centers" "conferencia" => "Barcelona, Spain: September" "serieFecha" => "2007" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primary cutaneous melanoma with regression does not require a lower threshold for sentinel lymph node biopsy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "K.T. Morris" 1 => "K.J. Busam" 2 => "S. Bero" 3 => "A. Patel" 4 => "M.S. Brady" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1245/s10434-007-9675-2" "Revista" => array:6 [ "tituloSerie" => "Ann Surg Oncol" "fecha" => "2008" "volumen" => "15" "paginaInicial" => "316" "paginaFinal" => "322" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18004626" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Partial regression of primary cutaneous melanoma: is there an association with sub-clinical sentinel lymph node metastasis?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "D. Fontaine" 1 => "W. Parkhill" 2 => "W. Greer" 3 => "N. Walsh" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Dermatopathol" "fecha" => "2003" "volumen" => "25" "paginaInicial" => "371" "paginaFinal" => "376" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14501285" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The correlation of regression in primary melanoma with sentinel lymph node status" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Kaur" 1 => "R.J. Thomas" 2 => "N. Desai" 3 => "M.A. Green" 4 => "D. Lovell" 5 => "B.W. Powell" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/jcp.2007.049411" "Revista" => array:6 [ "tituloSerie" => "J Clin Pathol" "fecha" => "2008" "volumen" => "61" "paginaInicial" => "297" "paginaFinal" => "300" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17675538" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The regressing thin malignant melanoma: a distinctive lesion with metastatic potential" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.A. Gromet" 1 => "W.L. Epstein" 2 => "M.S. Blois" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "1978" "volumen" => "42" "paginaInicial" => "2282" "paginaFinal" => "2292" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/719608" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Histological characteristics of metastasizing thin melanomas: a case-control study of 43 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Guitart" 1 => "L. Lowe" 2 => "M. Piepkorn" 3 => "V.G. Prieto" 4 => "M.S. Rabkin" 5 => "S.G. Ronan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "2002" "volumen" => "138" "paginaInicial" => "603" "paginaFinal" => "608" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12020220" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "“Thin” malignant melanoma: risk factors and clinical management" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C.L. Slingluff Jr" 1 => "H.F. Seigler" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Plast Surg" "fecha" => "1992" "volumen" => "28" "paginaInicial" => "89" "paginaFinal" => "94" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1642416" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Thin malignant melanomas with regression and metastases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S.G. Ronan" 1 => "A.M. Eng" 2 => "H.A. Briele" 3 => "N.N. Shioura" 4 => "T.K. Das Gupta" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "1987" "volumen" => "123" "paginaInicial" => "1326" "paginaFinal" => "1330" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3662564" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Model predicting survival in stage I melanoma based on tumor progression" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "W.H. Clark Jr" 1 => "D.E. Elder" 2 => "D. Guerry 4th" 3 => "L.E. Braitman" 4 => "B.J. Trock" 5 => "D. Schultz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Natl Cancer Inst" "fecha" => "1989" "volumen" => "81" "paginaInicial" => "1893" "paginaFinal" => "1904" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2593166" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Thin malignant melanomas (less than 1.5 mm) with metastasis: a histological study and survival analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "K. Blessing" 1 => "K.M. McLaren" 2 => "A. McLean" 3 => "P. Davidson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Histopathology" "fecha" => "1990" "volumen" => "17" "paginaInicial" => "389" "paginaFinal" => "395" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2076865" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Regression in malignant melanoma. A histologic feature without independent prognostic significance" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.W. Kelly" 1 => "R.W. Sagebiel" 2 => "M.S. Blois" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "1985" "volumen" => "56" "paginaInicial" => "2287" "paginaFinal" => "2291" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4052972" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prognosis in patients with thin malignant melanoma: influence of regression" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "V.J. McGovern" 1 => "H.M. Shaw" 2 => "G.W. Milton" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Histopathology" "fecha" => "1983" "volumen" => "7" "paginaInicial" => "673" "paginaFinal" => "680" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6629343" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Histologic features of tumors and the female superiority in survival from malignant melanoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "H.M. Shaw" 1 => "V.J. McGovern" 2 => "G.W. Milton" 3 => "G.A. Farago" 4 => "W.H. McCarthy" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "1980" "volumen" => "45" "paginaInicial" => "1604" "paginaFinal" => "1608" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7370919" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Biologic behavior of thin malignant melanomas with regressive changes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R.R. Paladugu" 1 => "R.H. Yonemoto" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Surg" "fecha" => "1983" "volumen" => "118" "paginaInicial" => "41" "paginaFinal" => "44" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6848075" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Regression in thin malignant melanoma. Microscopic diagnosis and prognostic importance" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "P.H. Cooper" 1 => "H.J. Wanebo" 2 => "R.W. Hagar" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "1985" "volumen" => "121" "paginaInicial" => "1127" "paginaFinal" => "1131" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4037837" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical features of superficial spreading melanomas with zones of regression" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "B.M. Czarnetzki" 1 => "M. Denter" 2 => "E.B. Brocker" 3 => "P. Rumke" 4 => "V. Krieg" 5 => "F. Vakilzadeh" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Cancer Res Clin Oncol" "fecha" => "1984" "volumen" => "107" "paginaInicial" => "225" "paginaFinal" => "228" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6736111" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "On the prognostic importance of white depressed areas in the primary lesion of superficial spreading melanoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "D.I. McLean" 1 => "R.A. Lew" 2 => "A.J. Sober" 3 => "M.C. Mihm Jr" 4 => "T.B. Fitzpatrick" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "1979" "volumen" => "43" "paginaInicial" => "157" "paginaFinal" => "161" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/761159" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A study of thin (< 1.5 mm) malignant melanomas with poor prognosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "K.G. Park" 1 => "K. Blessing" 2 => "K.M. McLaren" 3 => "A.C. Watson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Plast Surg" "fecha" => "1993" "volumen" => "46" "paginaInicial" => "607" "paginaFinal" => "610" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8252271" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Histologic regression in malignant melanoma: an interobserver concordance study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S. Kang" 1 => "R.L. Barnhill" 2 => "M.C. Mihm Jr" 3 => "A.J. Sober" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Cutan Pathol" "fecha" => "1993" "volumen" => "20" "paginaInicial" => "126" "paginaFinal" => "129" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8320356" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Histological diagnosis of nevi and melanoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G. Massi" 1 => "P. LeBoit" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:3 [ "fecha" => "2004" "editorial" => "Steinkopff Verlag Darmstadt" "editorialLocalizacion" => "Germany" ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prognostic value of tumor infiltrating lymphocytes in the vertical growth phase of primary cutaneous melanoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "C.G. Clemente" 1 => "M.C. Mihm Jr" 2 => "R. Bufalino" 3 => "S. Zurrida" 4 => "P. Collini" 5 => "N. Cascinelli" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/(SICI)1097-0142(19960401)77:7<1303::AID-CNCR12>3.0.CO;2-5" "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "1996" "volumen" => "77" "paginaInicial" => "1303" "paginaFinal" => "1310" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8608507" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fibrosis in regressing melanoma versus nonfibrosis in halo nevus upon melanocyte disappearance: could it be related to a different cytokine microenvironment?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S. Moretti" 1 => "A. Spallanzani" 2 => "C. Pinzi" 3 => "F. Prignano" 4 => "P. Fabbri" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1600-0560.2006.00616.x" "Revista" => array:6 [ "tituloSerie" => "J Cutan Pathol" "fecha" => "2007" "volumen" => "34" "paginaInicial" => "301" "paginaFinal" => "308" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17381800" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010000000009/v1_201304241507/S1578219009701714/v1_201304241507/en/main.assets" "Apartado" => array:4 [ "identificador" => "6176" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Controversies in Dermatology" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010000000009/v1_201304241507/S1578219009701714/v1_201304241507/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009701714?idApp=UINPBA000044" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 5 | 8 | 13 |
| 2024 October | 91 | 93 | 184 |
| 2024 September | 103 | 107 | 210 |
| 2024 August | 167 | 94 | 261 |
| 2024 July | 178 | 109 | 287 |
| 2024 June | 126 | 96 | 222 |
| 2024 May | 103 | 88 | 191 |
| 2024 April | 72 | 76 | 148 |
| 2024 March | 143 | 117 | 260 |
| 2024 February | 106 | 103 | 209 |
| 2024 January | 97 | 156 | 253 |
| 2023 December | 91 | 133 | 224 |
| 2023 November | 80 | 197 | 277 |
| 2023 October | 81 | 143 | 224 |
| 2023 September | 57 | 152 | 209 |
| 2023 August | 42 | 123 | 165 |
| 2023 July | 53 | 159 | 212 |
| 2023 June | 61 | 124 | 185 |
| 2023 May | 49 | 159 | 208 |
| 2023 April | 35 | 125 | 160 |
| 2023 March | 32 | 126 | 158 |
| 2023 February | 43 | 117 | 160 |
| 2023 January | 44 | 138 | 182 |
| 2022 December | 61 | 119 | 180 |
| 2022 November | 27 | 110 | 137 |
| 2022 October | 42 | 110 | 152 |
| 2022 September | 53 | 132 | 185 |
| 2022 August | 27 | 141 | 168 |
| 2022 July | 40 | 153 | 193 |
| 2022 June | 29 | 166 | 195 |
| 2022 May | 72 | 179 | 251 |
| 2022 April | 85 | 101 | 186 |
| 2022 March | 77 | 144 | 221 |
| 2022 February | 30 | 122 | 152 |
| 2022 January | 49 | 288 | 337 |
| 2021 December | 45 | 186 | 231 |
| 2021 November | 42 | 214 | 256 |
| 2021 October | 56 | 213 | 269 |
| 2021 September | 43 | 163 | 206 |
| 2021 August | 46 | 176 | 222 |
| 2021 July | 37 | 176 | 213 |
| 2021 June | 43 | 190 | 233 |
| 2021 May | 26 | 212 | 238 |
| 2021 April | 94 | 365 | 459 |
| 2021 March | 64 | 242 | 306 |
| 2021 February | 53 | 158 | 211 |
| 2021 January | 43 | 144 | 187 |
| 2020 December | 47 | 149 | 196 |
| 2020 November | 31 | 108 | 139 |
| 2020 October | 44 | 116 | 160 |
| 2020 September | 36 | 60 | 96 |
| 2020 August | 29 | 94 | 123 |
| 2020 July | 12 | 54 | 66 |
| 2020 June | 34 | 74 | 108 |
| 2020 May | 22 | 49 | 71 |
| 2020 April | 18 | 48 | 66 |
| 2020 March | 12 | 45 | 57 |
| 2020 February | 2 | 26 | 28 |
| 2020 January | 0 | 31 | 31 |
| 2019 December | 0 | 33 | 33 |
| 2019 November | 0 | 21 | 21 |
| 2019 October | 0 | 24 | 24 |
| 2019 September | 0 | 35 | 35 |
| 2019 August | 0 | 23 | 23 |
| 2019 July | 0 | 31 | 31 |
| 2019 June | 0 | 32 | 32 |
| 2019 May | 2 | 82 | 84 |
| 2019 April | 0 | 69 | 69 |
| 2019 March | 0 | 11 | 11 |
| 2019 February | 0 | 17 | 17 |
| 2019 January | 0 | 8 | 8 |
| 2018 December | 0 | 15 | 15 |
| 2018 November | 1 | 4 | 5 |
| 2018 September | 0 | 9 | 9 |
| 2018 August | 0 | 35 | 35 |
| 2018 July | 0 | 25 | 25 |
| 2018 June | 0 | 26 | 26 |
| 2018 May | 0 | 37 | 37 |
| 2018 April | 0 | 31 | 31 |
| 2018 March | 1 | 40 | 41 |
| 2018 February | 19 | 102 | 121 |
| 2018 January | 14 | 126 | 140 |
| 2017 December | 25 | 85 | 110 |
| 2017 November | 25 | 139 | 164 |
| 2017 October | 21 | 132 | 153 |
| 2017 September | 26 | 142 | 168 |
| 2017 August | 20 | 111 | 131 |
| 2017 July | 12 | 122 | 134 |
| 2017 June | 23 | 158 | 181 |
| 2017 May | 22 | 115 | 137 |
| 2017 April | 22 | 100 | 122 |
| 2017 March | 21 | 133 | 154 |
| 2017 February | 17 | 130 | 147 |
| 2017 January | 27 | 97 | 124 |
| 2016 December | 44 | 101 | 145 |
| 2016 November | 29 | 117 | 146 |
| 2016 October | 25 | 146 | 171 |
| 2016 September | 36 | 151 | 187 |
| 2016 August | 107 | 123 | 230 |
| 2016 July | 61 | 78 | 139 |
| 2016 June | 12 | 54 | 66 |
| 2016 May | 7 | 36 | 43 |
| 2016 April | 7 | 1 | 8 |
| 2016 March | 6 | 2 | 8 |
| 2016 February | 6 | 37 | 43 |
| 2016 January | 11 | 26 | 37 |
| 2015 December | 11 | 2 | 13 |
| 2015 November | 10 | 2 | 12 |
| 2015 October | 7 | 33 | 40 |
| 2015 September | 6 | 1 | 7 |
| 2015 August | 7 | 20 | 27 |
| 2015 July | 31 | 52 | 83 |
| 2015 June | 34 | 71 | 105 |
| 2015 May | 58 | 67 | 125 |
| 2015 April | 29 | 55 | 84 |
| 2015 March | 25 | 67 | 92 |
| 2015 February | 21 | 56 | 77 |
| 2015 January | 26 | 43 | 69 |
| 2014 December | 28 | 41 | 69 |
| 2014 November | 17 | 28 | 45 |
| 2014 October | 27 | 40 | 67 |
| 2014 September | 35 | 30 | 65 |
| 2014 August | 51 | 28 | 79 |
| 2014 July | 38 | 35 | 73 |
| 2014 June | 47 | 12 | 59 |
| 2014 May | 46 | 19 | 65 |
| 2014 April | 44 | 12 | 56 |
| 2014 March | 52 | 81 | 133 |
| 2014 February | 25 | 101 | 126 |
| 2014 January | 42 | 111 | 153 |
| 2013 December | 28 | 71 | 99 |
| 2013 November | 31 | 105 | 136 |
| 2013 October | 33 | 91 | 124 |
| 2013 September | 32 | 120 | 152 |
| 2013 August | 34 | 182 | 216 |
| 2013 July | 34 | 214 | 248 |
| 2013 June | 24 | 131 | 155 |
| 2013 May | 29 | 63 | 92 |
| 2013 April | 40 | 72 | 112 |
| 2013 March | 42 | 40 | 82 |
| 2013 February | 25 | 20 | 45 |
| 2013 January | 7 | 3 | 10 |
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