Extracorporeal Photopheresis in Dermatology | Actas Dermo-Sifiliográficas

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"apellidos" => "Pérez-Carmona" "email" => array:1 [ 0 => "lpcarmona@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "¿" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "A." "apellidos" => "Harto-Castaño" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff1" ] ] ] 2 => array:3 [ "nombre" => "E." "apellidos" => "Díez-Recio" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "b" "identificador" => "aff2" ] ] ] 3 => array:3 [ "nombre" => "P." "apellidos" => "Jaén-Olasolo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff1" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital Ramón y Cajal, Universidad de Alcalá, Madrid, Spain" "etiqueta" => "a" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital Universitario de Guadalajara, Universidad de Alcalá, Guadalajara, Spain" "etiqueta" => "b" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Servicio de Dermatología, Hospital Ramón y Cajal, Carretera de Colmenar Viejo, km 9,100, 28034 Madrid, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Fotoféresis Extracorpórea en Dermatología" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2009-02-11" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84509" "palabras" => array:4 [ 0 => "photopheresis" 1 => "photochemotherapy" 2 => "extracorporeal" 3 => "treatment" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84510" "palabras" => array:4 [ 0 => "fotoféresis" 1 => "fotoquimioterapia" 2 => "extracorpórea" 3 => "tratamiento" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "Extracorporeal photochemotherapy or photopheresis is an immunomodulatory therapy that combines leukapheresis with phototherapy. Blood from the patient is processed to give a leukocyte-rich plasma, which is then treated ex vivo with a photosensitizer and ultraviolet A radiation before reinfusion back into the patient. The exact mechanism of action of photopheresis has not been fully elucidated although it is thought that induction of leukocyte apoptosis and formation of dendritic cells is essential for the development of an immune response to pathogenic cells. Extracorporeal photopheresis was initially used for treating cutaneous T-cell lymphoma. Since then, in view of its efficacy and safety, it has been used in a number of cutaneous and non cutaneous diseases with uneven results, which can in part be explained by the different patient selection criteria, therapy regimens, and follow-up protocols used in different hospitals." ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "La fotoquimioterapia extracorpórea o fotoféresis es una terapia inmunomoduladora que combina la leucoféresis con la fototerapia. Después de la separación de un plasma rico en leucocitos, se administra ex vivo un fotosensibilizante junto con radiación ultravioleta A y posteriormente se reinfunde en el paciente. El mecanismo de acción exacto de la fotoféresis no se conoce completamente, aunque se piensa que la inducción de apoptosis de linfocitos y la formación de células dendríticas desempeña un papel fundamental en el desarrollo de una respuesta inmunológica contra las células patógenas. Esta terapia se utilizó inicialmente para el tratamiento del linfoma cutáneo de células T. Desde entonces, basándose en su eficacia y seguridad, se ha empleado en múltiples patologías tanto cutáneas como no cutáneas, con resultados variables. 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Controversies in dermatology

Extracorporeal Photopheresis in Dermatology

Fotoféresis Extracorpórea en Dermatología

L. Pérez-Carmonaa,

Corresponding author

lpcarmona@hotmail.com

Correspondence: Servicio de Dermatología, Hospital Ramón y Cajal, Carretera de Colmenar Viejo, km 9,100, 28034 Madrid, Spain.

, A. Harto-Castañoa, E. Díez-Reciob, P. Jaén-Olasoloa

a Servicio de Dermatología, Hospital Ramón y Cajal, Universidad de Alcalá, Madrid, Spain

b Servicio de Dermatología, Hospital Universitario de Guadalajara, Universidad de Alcalá, Guadalajara, Spain

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        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Extracorporeal photochemotherapy or photopheresis is an immunomodulatory therapy that combines leukapheresis with phototherapy&#46; Blood from the patient is processed to give a leukocyte-rich plasma&#44; which is then treated ex vivo with a photosensitizer and ultraviolet A radiation before reinfusion back into the patient&#46; The exact mechanism of action of photopheresis has not been fully elucidated although it is thought that induction of leukocyte apoptosis and formation of dendritic cells is essential for the development of an immune response to pathogenic cells&#46; Extracorporeal photopheresis was initially used for treating cutaneous T-cell lymphoma&#46; Since then&#44; in view of its efficacy and safety&#44; it has been used in a number of cutaneous and non cutaneous diseases with uneven results&#44; which can in part be explained by the different patient selection criteria&#44; therapy regimens&#44; and follow-up protocols used in different hospitals&#46;</p>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">La fotoquimioterapia extracorp&#243;rea o fotof&#233;resis es una terapia inmunomoduladora que combina la leucof&#233;resis con la fototerapia&#46; Despu&#233;s de la separaci&#243;n de un plasma rico en leucocitos&#44; se administra ex vivo un fotosensibilizante junto con radiaci&#243;n ultravioleta A y posteriormente se reinfunde en el paciente&#46; El mecanismo de acci&#243;n exacto de la fotof&#233;resis no se conoce completamente&#44; aunque se piensa que la inducci&#243;n de apoptosis de linfocitos y la formaci&#243;n de c&#233;lulas dendr&#237;ticas desempe&#241;a un papel fundamental en el desarrollo de una respuesta inmunol&#243;gica contra las c&#233;lulas pat&#243;genas&#46; Esta terapia se utiliz&#243; inicialmente para el tratamiento del linfoma cut&#225;neo de c&#233;lulas T&#46; Desde entonces&#44; bas&#225;ndose en su eficacia y seguridad&#44; se ha empleado en m&#250;ltiples patolog&#237;as tanto cut&#225;neas como no cut&#225;neas&#44; con resultados variables&#46; Los distintos centros han utilizado diferentes criterios de selecci&#243;n de pacientes&#44; pautas de tratamiento y protocolos de monitorizaci&#243;n&#44; lo que podr&#237;a contribuir a la diferencia de resultados&#46;</p>"
      ]
    ]
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Article information

ISSN: 15782190
Original language: English

DOI:10.1016/S1578-2190(09)70102-7

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2024 November	2	3	5
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2024 August	101	64	165
2024 July	70	44	114
2024 June	75	39	114
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2024 April	42	29	71
2024 March	69	48	117
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2023 October	44	32	76
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2023 August	36	19	55
2023 July	66	63	129
2023 June	94	33	127
2023 May	65	35	100
2023 April	38	31	69
2023 March	35	33	68
2023 February	22	30	52
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2022 December	50	49	99
2022 November	19	32	51
2022 October	19	33	52
2022 September	32	50	82
2022 August	42	55	97
2022 July	41	44	85
2022 June	23	29	52
2022 May	31	52	83
2022 April	32	56	88
2022 March	31	62	93
2022 February	33	47	80
2022 January	28	42	70
2021 December	37	42	79
2021 November	40	51	91
2021 October	32	64	96
2021 September	23	36	59
2021 August	46	37	83
2021 July	23	36	59
2021 June	37	45	82
2021 May	27	26	53
2021 April	47	70	117
2021 March	95	19	114
2021 February	92	28	120
2021 January	69	27	96
2020 December	48	17	65
2020 November	32	14	46
2020 October	39	7	46
2020 September	72	9	81
2020 August	18	15	33
2020 July	27	5	32
2020 June	23	28	51
2020 May	19	24	43
2020 April	26	16	42
2020 March	16	15	31
2020 February	2	6	8
2020 January	0	8	8
2019 December	0	6	6
2019 November	0	4	4
2019 October	0	2	2
2019 September	0	11	11
2019 August	0	17	17
2019 July	0	14	14
2019 June	0	18	18
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2019 April	0	10	10
2019 March	0	4	4
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2018 September	0	1	1
2018 August	0	1	1
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2018 January	19	5	24
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2017 October	23	9	32
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2017 August	25	15	40
2017 July	22	8	30
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2017 May	27	12	39
2017 April	36	8	44
2017 March	28	15	43
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2016 August	37	26	63
2016 July	28	13	41
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2015 August	14	6	20
2015 July	45	7	52
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2015 April	35	16	51
2015 March	36	18	54
2015 February	33	18	51
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2014 December	44	12	56
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2014 October	48	7	55
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2014 August	31	21	52
2014 July	37	16	53
2014 June	39	15	54
2014 May	42	7	49
2014 April	50	13	63
2014 March	47	21	68
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2013 December	29	20	49
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2013 October	41	32	73
2013 September	30	37	67
2013 August	40	34	74
2013 July	56	40	96
2013 June	38	32	70
2013 May	42	24	66
2013 April	38	32	70
2013 March	39	21	60
2013 February	35	17	52
2013 January	10	4	14

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