Original articles
Allergic Contact Dermatitis Due to Corticosteroids: A 3-Year Retrospective Study in a Hospital Skin Allergy Unit
Dermatitis de Contacto por Corticoides. Estudio Retrospectivo de 3 años en una Unidad de Alergia Cutánea Hospitalaria
M. Pérez-Crespo
, J.F. Silvestre, A. Lucas, J. Mataix, I. Ballester
Corresponding author
mariaperezcrespo@hotmail.com
Correspondence: Servicio de Dermatología, Hospital General Universitario de Alicante, C/ Pintor Baeza, s/n. 03010 Alicante, Spain.
Correspondence: Servicio de Dermatología, Hospital General Universitario de Alicante, C/ Pintor Baeza, s/n. 03010 Alicante, Spain.
Sección de Dermatología, Hospital General Universitario de Alicante, Spain
Read
6222
Timeswas read the article
2719
Total PDF
3503
Total HTML
Share statistics
array:23 [ "pii" => "S1578219009700666" "issn" => "15782190" "doi" => "10.1016/S1578-2190(09)70066-6" "estado" => "S300" "fechaPublicacion" => "2009-05-01" "aid" => "70066" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "copyrightAnyo" => "2009" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2009;100:291-7" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2209 "formatos" => array:3 [ "EPUB" => 37 "HTML" => 1437 "PDF" => 735 ] ] "itemSiguiente" => array:18 [ "pii" => "S1578219009700678" "issn" => "15782190" "doi" => "10.1016/S1578-2190(09)70067-8" "estado" => "S300" "fechaPublicacion" => "2009-05-01" "aid" => "70067" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2009;100:298-306" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2266 "formatos" => array:3 [ "EPUB" => 34 "HTML" => 1429 "PDF" => 803 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original articles</span>" "titulo" => "Validity of a Telephone Survey for Determining the Prevalence of Atopic Dermatitis and its Seasonal Variation in Spain" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "298" "paginaFinal" => "306" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Validez de una Encuesta Telefónica para Determinar la Prevalencia y la Estacionalidad de la Dermatitis Atópica en España" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A. García-Díez, Ll. Puig, J. Ortiz, A. Blanco" "autores" => array:4 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "García-Díez" ] 1 => array:2 [ "nombre" => "Ll." "apellidos" => "Puig" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "Ortiz" ] 3 => array:2 [ "nombre" => "A." "apellidos" => "Blanco" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009700678?idApp=UINPBA000044" "url" => "/15782190/0000010000000004/v1_201304241454/S1578219009700678/v1_201304241454/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1578219009700654" "issn" => "15782190" "doi" => "10.1016/S1578-2190(09)70065-4" "estado" => "S300" "fechaPublicacion" => "2009-05-01" "aid" => "70065" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2009;100:287-90" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2099 "formatos" => array:3 [ "EPUB" => 34 "HTML" => 1245 "PDF" => 820 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Actas 1909-2009</span>" "titulo" => "The First Article in The Journal <span class="elsevierStyleItalic">Actas Dermo-Sifiliográficas</span> Published With Photographs: Malignant Keratosis Diffusa Fetalis (Fetal Ichthyosis; Congenital Maligna Keratoma, Etc.), by Juan de Azúa" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "287" "paginaFinal" => "290" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "El Primer Artículo con Fotografías de la Revista <span class="elsevierStyleItalic">Actas Dermo-Sifiliográficas</span>: Hiperkeratosis Universal Congénita Maligna. (Ictiosis Fetal; Keratoma Maligno Congénito, etc.), por Juan de Azúa" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "R.M. Díaz-Díaz" "autores" => array:1 [ 0 => array:2 [ "nombre" => "R.M." "apellidos" => "Díaz-Díaz" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009700654?idApp=UINPBA000044" "url" => "/15782190/0000010000000004/v1_201304241454/S1578219009700654/v1_201304241454/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original articles</span>" "titulo" => "Allergic Contact Dermatitis Due to Corticosteroids: A 3-Year Retrospective Study in a Hospital Skin Allergy Unit" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "291" "paginaFinal" => "297" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "M. Pérez-Crespo, J.F. Silvestre, A. Lucas, J. Mataix, I. Ballester" "autores" => array:5 [ 0 => array:4 [ "nombre" => "M." "apellidos" => "Pérez-Crespo" "email" => array:1 [ 0 => "mariaperezcrespo@hotmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:2 [ "nombre" => "J.F." "apellidos" => "Silvestre" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Lucas" ] 3 => array:2 [ "nombre" => "J." "apellidos" => "Mataix" ] 4 => array:2 [ "nombre" => "I." "apellidos" => "Ballester" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Sección de Dermatología, Hospital General Universitario de Alicante, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Servicio de Dermatología, Hospital General Universitario de Alicante, C/ Pintor Baeza, s/n. 03010 Alicante, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Dermatitis de Contacto por Corticoides. Estudio Retrospectivo de 3 años en una Unidad de Alergia Cutánea Hospitalaria" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2008-07-04" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84459" "palabras" => array:4 [ 0 => "allergic contact dermatitis" 1 => "corticosteroids" 2 => "patch test" 3 => "standard battery" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84460" "palabras" => array:4 [ 0 => "dermatitis de contacto alérgica" 1 => "corticoides" 2 => "pruebas epicutáneas" 3 => "batería estándar GEIDAC" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p class="elsevierStyleSimplePara elsevierViewall">Corticosteroid contact dermatitis and its patch testing are subject to certain peculiarities that we should be aware of.</p> <span class="elsevierStyleSectionTitle">Materials and methods</span><p class="elsevierStyleSimplePara elsevierViewall">We performed a retrospective study of all patients who underwent patch tests with a corticosteroid battery in the Skin Allergy Unit of the Dermatology Department of Hospital General Universitario, Alicante, Spain, between October 2004 and June 2007.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">During the study period, patch tests were performed on 1065 patients in our allergy unit. A corticosteroid battery was used in 34 patients (3.1%). Fourteen patients were positive for budesonide or tixocortol in the standard battery; 20 were negative for these allergens but there was a clinical suspicion of steroid allergy. At least one positive reaction in the corticosteroid battery was observed in 15 patients (44.1%).The substance most commonly implicated was budesonide (13 patients sensitized). The corticosteroid battery revealed sensitization to other groups of corticosteroids in 4 of the 15 patients with corticosteroid sensitization. Seventeen patients brought drugs that were also tested, obtaining positive results for 10 substances.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Allergens for contact dermatitis due to corticosteroids included in the standard battery (budesonide and tixocortol) detected 93% of patients who are sensitized to steroids; there would appear to be little benefit in performing a corticosteroid battery if those markers are negative. The battery of corticosteroids and the drugs provided by patients were useful to define more exactly the corticosteroid classes that the patient should avoid.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p class="elsevierStyleSimplePara elsevierViewall">La dermatitis de contacto por corticoides y la realización de las pruebas epicutáneas con estas sustancias presentan peculiaridades que hay que conocer.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Realizamos un estudio retrospectivo de todos los pacientes en los que se aplicó la batería de corticoides en la Unidad de Alergia Cutánea de la Sección de Dermatología del Hospital General Universitario de Alicante, durante el período comprendido entre octubre de 2004 y junio de 2007.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Durante el período de estudio se atendieron 1.065 pacientes, a 34 de ellos (3,1%) se les aplicó la batería de corticoides, 14 pacientes con budesonida o tixocortol positivos en la batería estándar y 20 con estos marcadores negativos pero con sospecha clínica de alergia a corticoides. Quince pacientes (44,1%) obtuvieron algún positivo en la batería de corticoides. La sustancia que más positivos obtuvo fue budesonida (13 pacientes sensibilizados). En 4 de 15 pacientes el uso de la batería de corticoides informó de sensibilización a otros grupos de corticoides. A 17 pacientes se les aplicaron los medicamentos aportados por ellos, obteniéndose 10 sustancias positivas.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Los marcadores para la dermatitis de contacto por corticoides presentes en la batería estándar (budesonida y tixocortol) detectaron el 93% de pacientes sensibilizados a corticoides, por lo que no parece rentable aplicar la batería de corticoides si dichos marcadores son negativos. La batería de corticoides y los propios fármacos aportados por los pacientes fueron útiles para definir mejor los grupos de corticoides que estos no pueden utilizar.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:17 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Recommendation to include budesonide and tixocortol pivalate in the European standard series. ESCD and EECDRG. European Society of Contact Dermatitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M. Isaksson" 1 => "F.M. Brandão" 2 => "M. Bruze" 3 => "A. Goossens" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Contact Dermatitis" "fecha" => "2000" "volumen" => "43" "paginaInicial" => "41" "paginaFinal" => "42" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10902588" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Corticosteroid classes: a quick reference guide including patch test substances and cross-reactivity" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S.E. Jacob" 1 => "T. Steele" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2005.12.028" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2006" "volumen" => "54" "paginaInicial" => "723" "paginaFinal" => "727" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16546601" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fisher's contact dermatitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R.L. Rietschel" 1 => "J.F. Fowler" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:4 [ "edicion" => "5th ed." "fecha" => "2001" "editorial" => "Louisiana State University, New Orleans" "editorialLocalizacion" => "Lippincott Williams & Wilkins" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Corticosteroid contact allergy: an EECDRG multicentre study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Dooms-Goossens" 1 => "K.E. Andersen" 2 => "F.M. Brandäo" 3 => "D. Bruynzeel" 4 => "D. Burrows" 5 => "J. Camarasa" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Contact Dermatitis" "fecha" => "1996" "volumen" => "35" "paginaInicial" => "40" "paginaFinal" => "44" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8896953" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Estudio epidemiológico de la dermatitis alérgica de contacto de España (2001)" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "Grupo Español de Investigación de Dermatitis de Contacto" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2004" "volumen" => "95" "paginaInicial" => "14" "paginaFinal" => "24" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dermatitis de contacto por corticoides tópicos" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M. Jones Caballero" 1 => "M.D. Guimaraens Juanena" 2 => "C. Villegas Fernández" 3 => "P. Fernández Peñas" 4 => "L. Conde-Salazar Gómez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Actas Dermo-Sif" "fecha" => "1993" "volumen" => "84" "paginaInicial" => "641" "paginaFinal" => "644" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Eczema alérgico de contacto por propionato de clobetasol" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J. Ortiz" 1 => "L. Borrego Hernando" 2 => "P. de Pablo Martín" 3 => "R. Ruiz Rodríguez" 4 => "L. Iglesias Díez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Actas Dermo-Sif" "fecha" => "1991" "volumen" => "82" "paginaInicial" => "848" "paginaFinal" => "851" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Results of patch testing to a corticosteroid series: a retrospective review of 1188 patients during 6 years at Mayo Clinic" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.D. Davis" 1 => "R.A. el-Azhary" 2 => "S.A. Farmer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2006.11.012" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2007" "volumen" => "56" "paginaInicial" => "921" "paginaFinal" => "927" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17239989" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reaktionen auf andere Kortikosteroide bei Patienten mit allergischer Kontactdermatitis infolge Hidrocortison" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S.M. Wilkinson" 1 => "S. Hollis" 2 => "M.H. Beck" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Z Haut Geschlechtskr" "fecha" => "1995" "volumen" => "70" "paginaInicial" => "368" "paginaFinal" => "372" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Allergy to inhaled corticosteroids: a review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A. Dooms-Goossens" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Contact Dermatitis" "fecha" => "1995" "volumen" => "6" "paginaInicial" => "1" "paginaFinal" => "3" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6105038" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Corticosteroid-induced contact dermatitis: a pragmatic approach" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.S. English" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Exp Dermatol" "fecha" => "2000" "volumen" => "25" "paginaInicial" => "261" "paginaFinal" => "264" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10971480" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Delayed systemic allergic reactions to corticosteroids" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "S.E. Whitmore" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Contact Dermatitis" "fecha" => "1995" "volumen" => "32" "paginaInicial" => "193" "paginaFinal" => "198" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7600773" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Exacerbation of asthma after nebulised beclomethasone diproprionate" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R.J. Clark" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1986" "volumen" => "2" "paginaInicial" => "574" "paginaFinal" => "575" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2570281" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Connubial contact dermatitis to an inhaled corticosteroid" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "N. Raison-Peyron" 1 => "H.B. Co Minh" 2 => "A. Vidal-Mazuy" 3 => "J.J. Guilhou" 4 => "B. Guillot" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Dermatol Venereol" "fecha" => "2005" "volumen" => "132" "paginaInicial" => "143" "paginaFinal" => "146" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15798566" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Angioedema and dysphagia caused by contact allergy to inhaled budesonide" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C. Pirker" 1 => "A. Misic’" 2 => "P.J. Frosch" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Contact Dermatitis" "fecha" => "2003" "volumen" => "49" "paginaInicial" => "77" "paginaFinal" => "79" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14641354" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Erythema-multiforme-like contact dermatitis from budesonide" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "L. Stingeni" 1 => "S. Caraffini" 2 => "D. Assalve" 3 => "V. Lapomarda" 4 => "P. Lisi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Contact Dermatitis" "fecha" => "1996" "volumen" => "34" "paginaInicial" => "154" "paginaFinal" => "155" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8681557" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Corticosteroid allergy: report of 3 unusually acute cases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M. Rodríguez-Serna" 1 => "J.F. Silvestre" 2 => "E. Quecedo" 3 => "A. Martínez" 4 => "F.J. Miguel" 5 => "R. Gauchía" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Contact Dermatitis" "fecha" => "1996" "volumen" => "35" "paginaInicial" => "361" "paginaFinal" => "362" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9118631" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010000000004/v1_201304241454/S1578219009700666/v1_201304241454/en/main.assets" "Apartado" => array:4 [ "identificador" => "6155" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original Articles" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010000000004/v1_201304241454/S1578219009700666/v1_201304241454/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009700666?idApp=UINPBA000044" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 1 | 2 | 3 |
| 2024 October | 87 | 30 | 117 |
| 2024 September | 66 | 30 | 96 |
| 2024 August | 88 | 59 | 147 |
| 2024 July | 78 | 29 | 107 |
| 2024 June | 79 | 30 | 109 |
| 2024 May | 85 | 31 | 116 |
| 2024 April | 88 | 36 | 124 |
| 2024 March | 65 | 29 | 94 |
| 2024 February | 51 | 31 | 82 |
| 2024 January | 44 | 42 | 86 |
| 2023 December | 58 | 25 | 83 |
| 2023 November | 48 | 27 | 75 |
| 2023 October | 52 | 16 | 68 |
| 2023 September | 34 | 22 | 56 |
| 2023 August | 23 | 13 | 36 |
| 2023 July | 40 | 37 | 77 |
| 2023 June | 36 | 26 | 62 |
| 2023 May | 41 | 22 | 63 |
| 2023 April | 21 | 380 | 401 |
| 2023 March | 26 | 19 | 45 |
| 2023 February | 22 | 21 | 43 |
| 2023 January | 28 | 21 | 49 |
| 2022 December | 21 | 37 | 58 |
| 2022 November | 19 | 29 | 48 |
| 2022 October | 22 | 24 | 46 |
| 2022 September | 13 | 39 | 52 |
| 2022 August | 9 | 30 | 39 |
| 2022 July | 13 | 30 | 43 |
| 2022 June | 17 | 27 | 44 |
| 2022 May | 21 | 39 | 60 |
| 2022 April | 19 | 41 | 60 |
| 2022 March | 29 | 58 | 87 |
| 2022 February | 22 | 22 | 44 |
| 2022 January | 18 | 34 | 52 |
| 2021 December | 26 | 39 | 65 |
| 2021 November | 27 | 53 | 80 |
| 2021 October | 48 | 47 | 95 |
| 2021 September | 24 | 42 | 66 |
| 2021 August | 17 | 24 | 41 |
| 2021 July | 16 | 20 | 36 |
| 2021 June | 24 | 31 | 55 |
| 2021 May | 15 | 32 | 47 |
| 2021 April | 44 | 52 | 96 |
| 2021 March | 63 | 24 | 87 |
| 2021 February | 61 | 20 | 81 |
| 2021 January | 34 | 25 | 59 |
| 2020 December | 15 | 15 | 30 |
| 2020 November | 21 | 16 | 37 |
| 2020 October | 27 | 16 | 43 |
| 2020 September | 22 | 8 | 30 |
| 2020 August | 20 | 25 | 45 |
| 2020 July | 16 | 12 | 28 |
| 2020 June | 29 | 29 | 58 |
| 2020 May | 42 | 18 | 60 |
| 2020 April | 49 | 16 | 65 |
| 2020 March | 34 | 30 | 64 |
| 2020 February | 8 | 2 | 10 |
| 2020 January | 0 | 7 | 7 |
| 2019 December | 0 | 5 | 5 |
| 2019 October | 0 | 10 | 10 |
| 2019 September | 0 | 3 | 3 |
| 2019 July | 0 | 6 | 6 |
| 2019 June | 0 | 7 | 7 |
| 2019 May | 0 | 46 | 46 |
| 2019 April | 0 | 16 | 16 |
| 2019 March | 0 | 4 | 4 |
| 2019 February | 0 | 5 | 5 |
| 2019 January | 0 | 2 | 2 |
| 2018 December | 0 | 8 | 8 |
| 2018 September | 0 | 1 | 1 |
| 2018 August | 0 | 2 | 2 |
| 2018 July | 0 | 1 | 1 |
| 2018 June | 0 | 2 | 2 |
| 2018 May | 0 | 10 | 10 |
| 2018 April | 0 | 2 | 2 |
| 2018 February | 7 | 4 | 11 |
| 2018 January | 16 | 9 | 25 |
| 2017 December | 14 | 10 | 24 |
| 2017 November | 15 | 3 | 18 |
| 2017 October | 13 | 12 | 25 |
| 2017 September | 12 | 8 | 20 |
| 2017 August | 31 | 6 | 37 |
| 2017 July | 12 | 2 | 14 |
| 2017 June | 19 | 18 | 37 |
| 2017 May | 16 | 20 | 36 |
| 2017 April | 12 | 16 | 28 |
| 2017 March | 12 | 22 | 34 |
| 2017 February | 20 | 6 | 26 |
| 2017 January | 11 | 7 | 18 |
| 2016 December | 29 | 5 | 34 |
| 2016 November | 22 | 4 | 26 |
| 2016 October | 24 | 12 | 36 |
| 2016 September | 51 | 4 | 55 |
| 2016 August | 47 | 10 | 57 |
| 2016 July | 27 | 9 | 36 |
| 2016 June | 12 | 4 | 16 |
| 2016 May | 4 | 5 | 9 |
| 2016 April | 6 | 3 | 9 |
| 2016 March | 6 | 0 | 6 |
| 2016 February | 7 | 2 | 9 |
| 2016 January | 8 | 1 | 9 |
| 2015 December | 8 | 0 | 8 |
| 2015 November | 8 | 1 | 9 |
| 2015 October | 6 | 2 | 8 |
| 2015 September | 7 | 3 | 10 |
| 2015 August | 11 | 5 | 16 |
| 2015 July | 27 | 3 | 30 |
| 2015 June | 36 | 10 | 46 |
| 2015 May | 52 | 12 | 64 |
| 2015 April | 32 | 7 | 39 |
| 2015 March | 27 | 11 | 38 |
| 2015 February | 24 | 7 | 31 |
| 2015 January | 20 | 9 | 29 |
| 2014 December | 24 | 9 | 33 |
| 2014 November | 23 | 15 | 38 |
| 2014 October | 26 | 14 | 40 |
| 2014 September | 33 | 11 | 44 |
| 2014 August | 42 | 14 | 56 |
| 2014 July | 37 | 26 | 63 |
| 2014 June | 40 | 12 | 52 |
| 2014 May | 49 | 13 | 62 |
| 2014 April | 32 | 6 | 38 |
| 2014 March | 51 | 16 | 67 |
| 2014 February | 32 | 11 | 43 |
| 2014 January | 45 | 14 | 59 |
| 2013 December | 38 | 11 | 49 |
| 2013 November | 30 | 15 | 45 |
| 2013 October | 18 | 16 | 34 |
| 2013 September | 19 | 18 | 37 |
| 2013 August | 32 | 14 | 46 |
| 2013 July | 25 | 18 | 43 |
| 2013 June | 23 | 15 | 38 |
| 2013 May | 16 | 9 | 25 |
| 2013 April | 15 | 20 | 35 |
| 2013 March | 20 | 16 | 36 |
| 2013 February | 32 | 8 | 40 |
| 2013 January | 24 | 5 | 29 |
Show all
