Novelties in dermatology
New Antibodies in Dermatomyositis
Nuevos Autoanticuerpos en la Dermatomiositis
I. Bielsa
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Servicio de Dermatología, Hospital Universitario Germans Trias i Pujol, Universidad Autónoma de Barcelona, Badalona, Barcelona, Spain
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"documento" => "article" "crossmark" => 0 "subdocumento" => "rev" "cita" => "Actas Dermosifiliogr. 2009;100:166-81" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2925 "formatos" => array:3 [ "EPUB" => 47 "HTML" => 1748 "PDF" => 1130 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Review article</span>" "titulo" => "Radiotherapy inb Dermatology" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "166" "paginaFinal" => "181" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Radioterapia en Dermatología" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A. Marín, E. Vargas-Díez, L. Cerezo" "autores" => array:3 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Marín" ] 1 => array:2 [ "nombre" => "E." "apellidos" => "Vargas-Díez" ] 2 => array:2 [ "nombre" => "L." "apellidos" => "Cerezo" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009700423?idApp=UINPBA000044" "url" => "/15782190/0000010000000003/v1_201304241451/S1578219009700423/v1_201304241451/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Novelties in dermatology</span>" "titulo" => "New Antibodies in Dermatomyositis" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "182" "paginaFinal" => "189" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "I. Bielsa" "autores" => array:1 [ 0 => array:4 [ "nombre" => "I." "apellidos" => "Bielsa" "email" => array:1 [ 0 => "ibielsa.germanstrias@gencat.cat" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Dermatología, Hospital Universitario Germans Trias i Pujol, Universidad Autónoma de Barcelona, Badalona, Barcelona, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: C/ Molas, 8 08302 Mataró, Barcelona, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Nuevos Autoanticuerpos en la Dermatomiositis" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2008-07-24" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84426" "palabras" => array:5 [ 0 => "idiopathic inflammatory myopathy" 1 => "polymyositis" 2 => "amyopathic dermatomyositis" 3 => "cancer-associated dermatomyositis" 4 => "myositis-specific antibodies" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84425" "palabras" => array:5 [ 0 => "miopatía inflamatoria idiopática" 1 => "polimiositis" 2 => "dermatomiositis amiopática" 3 => "dermatomiositis asociada a cáncer" 4 => "anticuerpos específicos de miositis" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Dermatomyositis is an idiopathic inflammatory myopathy that affects skeletal muscle and the skin. Idiopathic inflammatory myopathies are characterized by the production of autoantibodies directed against different cell structures. Some of these autoantibodies are specific to idiopathic inflammatory myopathies (myositis-specific antibodies) whereas others are found in a range of overlap syndromes (myositis-associated antibodies). Although they are all associated with certain clinical and physiopathological characteristics of myositis, myositis-specific antibodies are essentially the most useful markers for clinical diagnosis, classification, and prognosis in idiopathic inflammatory myopathies. In recent years, two new myositis-specific antibodies–-in clinically amyopathic dermatomyositis (CADM), CADM-140 and, in cancer-associated dermatomyositis, anti-p155/p140–-have been identified. This is of great importance as no myositis-specific antibodies had previously been detected in these clinical subgroups. The identification of target antigens that are recognized by these antibodies is essential for a better understanding of the pathogenesis of these diseases.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">La dermatomiositis es un tipo de miopatía inflamatoria idiopática que afecta al músculo esquelético y a la piel. Las miopatías inflamatorias idiopáticas se caracterizan por la producción de autoanticuerpos que se dirigen frente a diversas estructuras de la célula. Algunos de estos autoanticuerpos resultan específicos de las miopatías inflamatorias idiopáticas (anticuerpos específicos de miositis), mientras que otros se encuentran en diversos síndromes de solapamiento (anticuerpos asociados a miositis). Todos ellos determinan ciertas características clínicas y patofisiológicas de miositis, pero son principalmente los anticuerpos específicos de miositis los que constituyen marcadores muy útiles para el diagnóstico clínico, la clasificación y la predicción del pronóstico en las miopatías inflamatorias idiopáticas. En los últimos años se han identificado dos nuevos anticuerpos específicos de miositis, el anti-CADM-140 en la dermatomiositis amiopática y el anti-p155 y anti-p155/p140 en la dermatomiositis asociada a cáncer. Ello tiene una gran trascendencia ya que en estos subgrupos clínicos no se detectaban anticuerpos específicos de miositis. La identificación de los antígenos diana que reconocen estos anticuerpos resultará fundamental para comprender mejor la etiopatogenia de estas enfermedades.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:66 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Polymyositis, dermatomyositis and inclusion-body myositis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M.C. 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| 2024 May | 68 | 47 | 115 |
| 2024 April | 79 | 40 | 119 |
| 2024 March | 76 | 45 | 121 |
| 2024 February | 89 | 41 | 130 |
| 2024 January | 100 | 47 | 147 |
| 2023 December | 100 | 42 | 142 |
| 2023 November | 97 | 49 | 146 |
| 2023 October | 70 | 42 | 112 |
| 2023 September | 57 | 29 | 86 |
| 2023 August | 65 | 79 | 144 |
| 2023 July | 81 | 56 | 137 |
| 2023 June | 62 | 24 | 86 |
| 2023 May | 56 | 23 | 79 |
| 2023 April | 47 | 19 | 66 |
| 2023 March | 28 | 31 | 59 |
| 2023 February | 40 | 22 | 62 |
| 2023 January | 48 | 27 | 75 |
| 2022 December | 49 | 37 | 86 |
| 2022 November | 35 | 30 | 65 |
| 2022 October | 26 | 27 | 53 |
| 2022 September | 35 | 54 | 89 |
| 2022 August | 16 | 44 | 60 |
| 2022 July | 19 | 28 | 47 |
| 2022 June | 13 | 25 | 38 |
| 2022 May | 35 | 42 | 77 |
| 2022 April | 36 | 42 | 78 |
| 2022 March | 29 | 51 | 80 |
| 2022 February | 22 | 33 | 55 |
| 2022 January | 30 | 42 | 72 |
| 2021 December | 19 | 41 | 60 |
| 2021 November | 31 | 51 | 82 |
| 2021 October | 34 | 41 | 75 |
| 2021 September | 20 | 45 | 65 |
| 2021 August | 21 | 23 | 44 |
| 2021 July | 30 | 34 | 64 |
| 2021 June | 17 | 31 | 48 |
| 2021 May | 20 | 35 | 55 |
| 2021 April | 21 | 34 | 55 |
| 2021 March | 57 | 17 | 74 |
| 2021 February | 59 | 23 | 82 |
| 2021 January | 28 | 18 | 46 |
| 2020 December | 21 | 6 | 27 |
| 2020 November | 34 | 18 | 52 |
| 2020 October | 17 | 6 | 23 |
| 2020 September | 25 | 13 | 38 |
| 2020 August | 30 | 24 | 54 |
| 2020 July | 31 | 12 | 43 |
| 2020 June | 34 | 29 | 63 |
| 2020 May | 24 | 27 | 51 |
| 2020 April | 31 | 21 | 52 |
| 2020 March | 22 | 23 | 45 |
| 2020 February | 2 | 2 | 4 |
| 2020 January | 0 | 8 | 8 |
| 2019 December | 0 | 3 | 3 |
| 2019 November | 0 | 9 | 9 |
| 2019 October | 0 | 2 | 2 |
| 2019 September | 0 | 4 | 4 |
| 2019 August | 0 | 1 | 1 |
| 2019 July | 0 | 6 | 6 |
| 2019 May | 0 | 35 | 35 |
| 2019 April | 0 | 1 | 1 |
| 2019 March | 0 | 2 | 2 |
| 2019 February | 0 | 3 | 3 |
| 2018 May | 0 | 8 | 8 |
| 2018 April | 0 | 1 | 1 |
| 2018 March | 2 | 5 | 7 |
| 2018 February | 11 | 9 | 20 |
| 2018 January | 20 | 6 | 26 |
| 2017 December | 31 | 8 | 39 |
| 2017 November | 23 | 6 | 29 |
| 2017 October | 21 | 1 | 22 |
| 2017 September | 13 | 12 | 25 |
| 2017 August | 24 | 12 | 36 |
| 2017 July | 26 | 6 | 32 |
| 2017 June | 33 | 11 | 44 |
| 2017 May | 32 | 14 | 46 |
| 2017 April | 38 | 6 | 44 |
| 2017 March | 36 | 16 | 52 |
| 2017 February | 16 | 11 | 27 |
| 2017 January | 15 | 13 | 28 |
| 2016 December | 22 | 10 | 32 |
| 2016 November | 19 | 10 | 29 |
| 2016 October | 20 | 15 | 35 |
| 2016 September | 46 | 8 | 54 |
| 2016 August | 33 | 6 | 39 |
| 2016 July | 24 | 4 | 28 |
| 2016 June | 10 | 14 | 24 |
| 2016 May | 11 | 28 | 39 |
| 2016 April | 8 | 17 | 25 |
| 2016 March | 5 | 15 | 20 |
| 2016 February | 9 | 15 | 24 |
| 2016 January | 11 | 17 | 28 |
| 2015 December | 16 | 14 | 30 |
| 2015 November | 17 | 15 | 32 |
| 2015 October | 14 | 18 | 32 |
| 2015 September | 10 | 7 | 17 |
| 2015 August | 11 | 2 | 13 |
| 2015 July | 47 | 16 | 63 |
| 2015 June | 39 | 8 | 47 |
| 2015 May | 62 | 5 | 67 |
| 2015 April | 41 | 18 | 59 |
| 2015 March | 45 | 14 | 59 |
| 2015 February | 26 | 5 | 31 |
| 2015 January | 29 | 8 | 37 |
| 2014 December | 29 | 10 | 39 |
| 2014 November | 25 | 21 | 46 |
| 2014 October | 39 | 13 | 52 |
| 2014 September | 35 | 14 | 49 |
| 2014 August | 39 | 18 | 57 |
| 2014 July | 69 | 17 | 86 |
| 2014 June | 103 | 13 | 116 |
| 2014 May | 58 | 13 | 71 |
| 2014 April | 67 | 8 | 75 |
| 2014 March | 63 | 13 | 76 |
| 2014 February | 46 | 16 | 62 |
| 2014 January | 47 | 15 | 62 |
| 2013 December | 54 | 17 | 71 |
| 2013 November | 38 | 21 | 59 |
| 2013 October | 34 | 21 | 55 |
| 2013 September | 56 | 21 | 77 |
| 2013 August | 28 | 18 | 46 |
| 2013 July | 38 | 23 | 61 |
| 2013 June | 31 | 22 | 53 |
| 2013 May | 30 | 18 | 48 |
| 2013 April | 34 | 33 | 67 |
| 2013 March | 47 | 23 | 70 |
| 2013 February | 35 | 10 | 45 |
| 2013 January | 12 | 4 | 16 |
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