Review article
Anticoagulation and Antiplatelet Therapy in Dermatology
Anticoagulación y Antiagregación en Dermatología
P. Bassas
, R. Bartralot, V. García-Patos
Corresponding author
patriciabassas@hotmail.com
Correspondence: Servicio de Dermatología, Hospital Vall d’Hebron, Paseo Vall d’Hebron 119-129 08035 Barcelona, Spain.
Correspondence: Servicio de Dermatología, Hospital Vall d’Hebron, Paseo Vall d’Hebron 119-129 08035 Barcelona, Spain.
Servicio de Dermatología, Hospital Vall d’Hebron, Barcelona, Spain
Read
8593
Timeswas read the article
4993
Total PDF
3600
Total HTML
Share statistics
array:23 [ "pii" => "S1578219009700046" "issn" => "15782190" "doi" => "10.1016/S1578-2190(09)70004-6" "estado" => "S300" "fechaPublicacion" => "2009-01-01" "aid" => "70004" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "copyrightAnyo" => "2009" "documento" => "article" "crossmark" => 0 "subdocumento" => "rev" "cita" => "Actas Dermosifiliogr. 2009;100:7-16" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3246 "formatos" => array:3 [ "EPUB" => 37 "HTML" => 1436 "PDF" => 1773 ] ] "itemSiguiente" => array:18 [ "pii" => "S1578219009700058" "issn" => "15782190" "doi" => "10.1016/S1578-2190(09)70005-8" "estado" => "S300" "fechaPublicacion" => "2009-01-01" "aid" => "70005" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2009;100:17-21" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2307 "formatos" => array:3 [ "EPUB" => 33 "HTML" => 1405 "PDF" => 869 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Actas 1909-2009</span>" "titulo" => "Actas Dermo-Sifiliográficas, Volume 1, Number 1" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "17" "paginaFinal" => "21" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Actas Dermo-Sifiliográficas,Año 1, Número 1" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "E. del Río" "autores" => array:1 [ 0 => array:2 [ "nombre" => "E." "apellidos" => "del Río" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009700058?idApp=UINPBA000044" "url" => "/15782190/0000010000000001/v1_201304241446/S1578219009700058/v1_201304241446/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1578219009700034" "issn" => "15782190" "doi" => "10.1016/S1578-2190(09)70003-4" "estado" => "S300" "fechaPublicacion" => "2009-01-01" "aid" => "70003" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Actas Dermosifiliogr. 2009;100:3-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2361 "formatos" => array:3 [ "EPUB" => 38 "HTML" => 1281 "PDF" => 1042 ] ] "en" => array:8 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Opinion article</span>" "titulo" => "Narrowband Ultraviolet B Therapy in Psoriasis: Reality, Outlook, and Uncertainty" "tienePdf" => "en" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "3" "paginaFinal" => "6" ] ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J.M. Carrascosa" "autores" => array:1 [ 0 => array:2 [ "nombre" => "J.M." "apellidos" => "Carrascosa" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009700034?idApp=UINPBA000044" "url" => "/15782190/0000010000000001/v1_201304241446/S1578219009700034/v1_201304241446/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Review article</span>" "titulo" => "Anticoagulation and Antiplatelet Therapy in Dermatology" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "7" "paginaFinal" => "16" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "P. Bassas, R. Bartralot, V. García-Patos" "autores" => array:3 [ 0 => array:4 [ "nombre" => "P." "apellidos" => "Bassas" "email" => array:1 [ 0 => "patriciabassas@hotmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:2 [ "nombre" => "R." "apellidos" => "Bartralot" ] 2 => array:2 [ "nombre" => "V." "apellidos" => "García-Patos" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Dermatología, Hospital Vall d’Hebron, Barcelona, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Servicio de Dermatología, Hospital Vall d’Hebron, Paseo Vall d’Hebron 119-129 08035 Barcelona, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Anticoagulación y Antiagregación en Dermatología" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2008-04-03" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84360" "palabras" => array:6 [ 0 => "anticoagulants" 1 => "warfarin" 2 => "heparin" 3 => "surgery" 4 => "acetylsalicylic acid" 5 => "bleeding" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84359" "palabras" => array:6 [ 0 => "anticoagulantes" 1 => "warfarina" 2 => "heparina" 3 => "cirugía" 4 => "ácido acetilsalicílico" 5 => "sangrado" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">An increasing number of patients who are receiving anticoagulation or antiplatelet therapy require cutaneous surgery. Such pharmacotherapies are usually suspended based on experience in gynecologic, thoracic, and abdominal surgery. However, this practice may increase the risk of suffering a thromboembolic event. We review perioperative management of anticoagulant and antiplatelet therapy, complications associated with suspending therapy, and side effects.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Cada vez es mayor el número de pacientes que recibe tratamiento anticoagulante o antiagregante y que debe someterse a cirugía cutánea. Interrumpir estos tratamientos para prevenir el sangrado es una práctica habitual, extrapolada de las experiencias en cirugía ginecológica, torácica y abdominal. En este contexto, la suspensión de dichos tratamientos puede incrementar el riesgo de sufrir un evento tromboembólico. Realizamos una revisión sobre el manejo peroperatorio de los tratamientos anticoagulantes y antiagregantes, de las complicaciones acontecidas tras su suspensión, así como de sus efectos secundarios.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:51 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The management of patients on anticoagulants prior to cutaneous surgery: case report of a thromboembolic complication, review of the literature, and evidence-based recommendations" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Khalifeh" 1 => "R. Redett" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Plast Reconstr Surg" "fecha" => "2006" "volumen" => "118" "paginaInicial" => "110" "paginaFinal" => "117" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Postoperative stroke after stopping warfarin for cutaneous surgery" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C.F. Schanbacher" 1 => "R.G. Bennet" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Dermatol Surg" "fecha" => "2000" "volumen" => "26" "paginaInicial" => "785" "paginaFinal" => "789" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10940066" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Perioperative management of anticoagulants and platelet inhibitors for cutaneous surgery: a survey of current practice" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "O. Kovich" 1 => "C.C. Otley" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Dermatol Surg" "fecha" => "2002" "volumen" => "28" "paginaInicial" => "513" "paginaFinal" => "517" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12081682" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Controversies in perioperative management of blood thinners in dermatologic surgery: continue or discontinue?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Alcalay" 1 => "R. Alkalay" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1524-4725.2004.30333.x" "Revista" => array:6 [ "tituloSerie" => "Dermatol Surg" "fecha" => "2004" "volumen" => "30" "paginaInicial" => "1091" "paginaFinal" => "1094" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15274698" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Oral anticoagulants: mechanism of action, clinical effectiveness, and optimal therapeutic range" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Hirsh" 1 => "J.E. Dalen" 2 => "D.R. Anderson" 3 => "L. Poller" 4 => "H. Bussey" 5 => "J. Ansell" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2001" "volumen" => "119" "paginaInicial" => "8S" "paginaFinal" => "21S" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11157640" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Management of anticoagulation before and after elective surgery" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C. Kearon" 1 => "J. Hirsh" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "N Engl J Med" "fecha" => "1997" "volumen" => "22" "paginaInicial" => "506" "paginaFinal" => "511" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous surgery in patients receiving warfarin therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J. Alcalay" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Dermatol Surg" "fecha" => "2001" "volumen" => "27" "paginaInicial" => "756" "paginaFinal" => "758" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11493301" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Complications of cutaneous surgery in patients who are taking warfarin, aspirin, or nonsteroidal anti-inflammatory drugs" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "C.C. Otley" 1 => "J.L. Fewkes" 2 => "W. Frank" 3 => "S.M. Olbricht" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "1996" "volumen" => "132" "paginaInicial" => "161" "paginaFinal" => "166" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8629823" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Complications of minor cutaneous surgery in patients under anticoagulant treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "E. Kargi" 1 => "O. Babuccu" 2 => "M. Hosnuter" 3 => "B. Babuccu" 4 => "C. Altinyazar" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Aesth Plast Surg" "fecha" => "2002" "volumen" => "26" "paginaInicial" => "483" "paginaFinal" => "485" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intraoperative and postoperative bleeding problems in patients taking warfarin, aspirin, and nonsteroidal anti-inflammatory agents: a prospective study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "E.M. Billingsley" 1 => "M.E. Maloney" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Dermatol Surg" "fecha" => "1997" "volumen" => "23" "paginaInicial" => "381" "paginaFinal" => "385" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9179249" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Perioperative monitoring of warfarin in cutaneous surgery" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. Ah-Weng" 1 => "S. Natarajan" 2 => "S. Velangi" 3 => "J.A.A. Langtry" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2003" "volumen" => "149" "paginaInicial" => "386" "paginaFinal" => "389" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12932248" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bleeding complications in skin cancer surgery are associated with warfarin but not aspirin therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A.J. Dixon" 1 => "M.P. Dixon" 2 => "J.B. Dixon" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/bjs.5864" "Revista" => array:6 [ "tituloSerie" => "Br J Surg" "fecha" => "2007" "volumen" => "94" "paginaInicial" => "1356" "paginaFinal" => "1360" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17654609" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Postoperative bleeding and warfarin" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C. Blasdale" 1 => "C.M. Lawrence" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2007.08419.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2008" "volumen" => "158" "paginaInicial" => "522" "paginaFinal" => "526" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18241270" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Perioperative management of the chronically anti-coagulated patient" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.A. Heit" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Thromb Thrombolysis" "fecha" => "2001" "volumen" => "77" "paginaInicial" => "81" "paginaFinal" => "87" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of perioperative enoxaparin versus unfractionated heparin on bleeding indices in patients undergoing coronary artery bypass grafting" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "E.H. Kincaid" 1 => "M.L. Monroe" 2 => "D.L. Saliba" 3 => "N.D. Kon" 4 => "W.G. Byerly" 5 => "M.G. Reichert" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Thorac Surg" "fecha" => "2003" "volumen" => "76" "paginaInicial" => "124" "paginaFinal" => "128" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12842525" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Preoperative use of enoxaparin is not a risk factor for postoperative bleeding after coronary artery bypass surgery" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "B. Medalion" 1 => "G. Frenkel" 2 => "P. Patachenko" 3 => "E. Hauptman" 4 => "L. Sasson" 5 => "A. Schachner" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0022" "Revista" => array:6 [ "tituloSerie" => "J Thorac Cardiovasc Surg" "fecha" => "2003" "volumen" => "126" "paginaInicial" => "1875" "paginaFinal" => "1879" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14688699" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Management of patients taking anticoagulant, aspirin, non-steroidal anti-inflammatory and other anti-platelet drugs undergoing dermatological surgery" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G. Stables" 1 => "C.M. Lawrence" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Exp Dermatol" "fecha" => "2002" "volumen" => "27" "paginaInicial" => "432" "paginaFinal" => "435" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12372076" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of perioperative administration of a selective cyclooxygenase 2 inhibitor on pain management and recovery of function after knee replacement: a randomized controlled trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Buvanendran" 1 => "J.S. Kroin" 2 => "K.J. Tuman" 3 => "T.R. Lubenow" 4 => "D. Elmofty" 5 => "M. Moric" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/jama.290.18.2411" "Revista" => array:6 [ "tituloSerie" => "JAMA" "fecha" => "2003" "volumen" => "290" "paginaInicial" => "2411" "paginaFinal" => "2418" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14612477" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Does aspirin affect the outcome of minor cutaneous surgery?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "G.R. Bartlett" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Br J Plast Surg" "fecha" => "2001" "volumen" => "54" "paginaInicial" => "214" "paginaFinal" => "216" ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of aspirin and nonsteroidal anti-inflammatory drug therapy on bleeding complications in dermatological surgery patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C. Lawrence" 1 => "A. Sakuntabhai" 2 => "S. Tiling-Grosse" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "1994" "volumen" => "31" "paginaInicial" => "988" "paginaFinal" => "992" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7962782" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ticlopidine and clopidogrel" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M.J. Quinn" 1 => "D.J. Fitzgerald" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Circulation" "fecha" => "1999" "volumen" => "100" "paginaInicial" => "1667" "paginaFinal" => "1672" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10517740" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Drug-induced skin, nail and hair disorders" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "L. Valeyrie-Allanore" 1 => "B. Sassolas" 2 => "J.C. Roujeau" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Drug Saf" "fecha" => "2007" "volumen" => "30" "paginaInicial" => "1011" "paginaFinal" => "1030" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17973540" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Drug eruption reference manual" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.Z. Litt" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:4 [ "edicion" => "10th ed." "fecha" => "2004" "editorial" => "Taylor and Francis" "editorialLocalizacion" => "London" ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hypersensitivity reactions to anticoagulant drugs: diagnosis and management options" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A.J. Birchner" 1 => "T. Harr" 2 => "L. Hohenstein" 3 => "D.A. Tsakiris" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1398-9995.2006.01227.x" "Revista" => array:6 [ "tituloSerie" => "Allergy" "fecha" => "2006" "volumen" => "61" "paginaInicial" => "1432" "paginaFinal" => "1440" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17073874" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous necrosis induced by acenocumarol" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M. Valdivielso" 1 => "I. Longo" 2 => "M. Lecona" 3 => "P. Lázaro" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Eur Acad Dermatol Venereol" "fecha" => "2004" "volumen" => "18" "paginaInicial" => "211" "paginaFinal" => "215" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15009309" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Late-onset warfarin-induced skin necrosis: case report and review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D.W. Essex" 1 => "S.S. Wynn" 2 => "D.K. Jin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Hematol" "fecha" => "1998" "volumen" => "57" "paginaInicial" => "233" "paginaFinal" => "237" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9495376" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Purple toes syndrome associated with warfarin therapy in a patient with antiphospholipid syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D.B. Talmadge" 1 => "A.C. Spyropoulos" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pharmacotherapy" "fecha" => "2003" "volumen" => "23" "paginaInicial" => "674" "paginaFinal" => "677" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12741443" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "An unusual cutaneous reaction to anticoagulant therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A.P. Soisson" 1 => "K.K. Vu" 2 => "P.C. Brittain" 3 => "I. Chamales" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Mil Med" "fecha" => "1994" "volumen" => "159" "paginaInicial" => "252" "paginaFinal" => "253" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7518893" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Maculopapular rash due to coumarin derivatives" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.H. Kruis-de Vries" 1 => "B.H. Stricker" 2 => "P.J. Coenraads" 3 => "J.P. Nater" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Dermatologica" "fecha" => "1989" "volumen" => "178" "paginaInicial" => "109" "paginaFinal" => "111" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2522402" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Unusual cutaneous adverse reaction to warfarin therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S.J. Anthony" 1 => "S.K. Krick" 2 => "P.M. Mehta" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "South Med J" "fecha" => "1993" "volumen" => "86" "paginaInicial" => "1413" "paginaFinal" => "1414" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8272925" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib31" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Acute generalized exanthematous pustulosis from dalteparin" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "P. Komericki" 1 => "R. Grims" 2 => "B. Kränke" 3 => "W. Aberer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2007.05.025" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2007" "volumen" => "57" "paginaInicial" => "718" "paginaFinal" => "721" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17610994" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib32" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Heparin-induced thrombocytopenia: pathophysiology and management" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "L. Mureebe" 1 => "D. Silver" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Vasc Endovascular Surg" "fecha" => "2002" "volumen" => "36" "paginaInicial" => "163" "paginaFinal" => "170" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12075381" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib33" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Low-molecular-weight heparin-induced skin necrosis: a potential association with pre-existent hypercoagulable states" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A. Toll" 1 => "F. Gallardo" 2 => "E. Abella" 3 => "J. Fontcuberta" 4 => "C. Barranco" 5 => "R.M. Pujol" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-4632.2004.02326.x" "Revista" => array:6 [ "tituloSerie" => "Int J Dermatol" "fecha" => "2005" "volumen" => "44" "paginaInicial" => "964" "paginaFinal" => "966" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16336536" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib34" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Heparin-induced thrombocytopenia: a ten-year retrospective" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "T.E. Warkentin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1146/annurev.med.50.1.129" "Revista" => array:6 [ "tituloSerie" => "Annu Rev Med" "fecha" => "1999" "volumen" => "50" "paginaInicial" => "129" "paginaFinal" => "147" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10073268" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib35" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Allergy to heparin, heparinoids, and recombinant hirudin. Diagnostic and therapeutic alternatives" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "U. Jappe" 1 => "H. Gollnick" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Hautartzt" "fecha" => "1999" "volumen" => "50" "paginaInicial" => "406" ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib36" "etiqueta" => "36." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A randomized, blinded trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE)" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "CAPRIE Steering Comittee" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1996" "volumen" => "348" "paginaInicial" => "1329" "paginaFinal" => "1339" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8918275" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib37" "etiqueta" => "37." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clopidogrel-associated TTP: an update of pharmacovigilance efforts conducted by independent researchers, pharmaceutical suppliers, and the Food and Drug Administration" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Zakarija" 1 => "N. Bandarenko" 2 => "D.K. Pandey" 3 => "A. Auerbach" 4 => "D.W. Raisch" 5 => "B. Kim" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1161/01.STR.0000109253.66918.5E" "Revista" => array:6 [ "tituloSerie" => "Stroke" "fecha" => "2004" "volumen" => "35" "paginaInicial" => "533" "paginaFinal" => "537" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14707231" "web" => "Medline" ] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib38" "etiqueta" => "38." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Suberythrodermic pustular psoriasis induced by clopidogrel" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M. Meissner" 1 => "C. Beier" 2 => "M. Wolter" 3 => "R. Kaufmann" 4 => "J. Gille" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2006.07370.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2006" "volumen" => "155" "paginaInicial" => "627" "paginaFinal" => "644" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16911294" "web" => "Medline" ] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib39" "etiqueta" => "39." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clopidogrel bisulphate-induced photosensitive lichenoid eruption: first report" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S. Dogra" 1 => "A.J. Kanwar" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2003" "volumen" => "148" "paginaInicial" => "609" "paginaFinal" => "610" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12653774" "web" => "Medline" ] ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib40" "etiqueta" => "40." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clopidogrel-induced hypersensitivity syndrome associated with febrile pancytopenia" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Comert" 1 => "S. Akgun" 2 => "A. Civelek" 3 => "M. Kavala" 4 => "S. Sarigül" 5 => "T. Yildirim" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-4632.2005.02366b.x" "Revista" => array:6 [ "tituloSerie" => "Int J Dermatol" "fecha" => "2005" "volumen" => "44" "paginaInicial" => "882" "paginaFinal" => "884" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16207199" "web" => "Medline" ] ] ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib41" "etiqueta" => "41." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clopidogrel hypersensitivity syndrome with rash, fever, and neutropenia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.P. Doogue" 1 => "E.J. Begg" 2 => "P. Bridgman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Mayo Clinic Proc" "fecha" => "2005" "volumen" => "80" "paginaInicial" => "1368" "paginaFinal" => "1370" ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib42" "etiqueta" => "42." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vasculitis leucocitoclástica en relación con ticlopidina" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "E. Pintor" 1 => "M. Sanmartín" 2 => "L. Azcona" 3 => "R. Hernández" 4 => "A. Fernández-Cruz" 5 => "C. Macaya" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rev Esp Cardiol" "fecha" => "2001" "volumen" => "54" "paginaInicial" => "114" "paginaFinal" => "116" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11141463" "web" => "Medline" ] ] ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib43" "etiqueta" => "43." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Rash in patients receiving ticlopidine after coronary stent placement" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "T.R. Whetsel" 1 => "D.M. Bell" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pharmacotherapy" "fecha" => "1999" "volumen" => "19" "paginaInicial" => "228" "paginaFinal" => "231" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10030774" "web" => "Medline" ] ] ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bib44" "etiqueta" => "44." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Incidence of side-effects of ticlopidine after sirolimus-eluting stent implantation" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "K. Fukushima" 1 => "Y. Kobayashi" 2 => "T. Okuno" 3 => "Y. Nakamura" 4 => "M. Sakakibara" 5 => "T. Nakayama" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Circ J" "fecha" => "2007" "paginaInicial" => "617" "paginaFinal" => "619" ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bib45" "etiqueta" => "45." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fixed drug eruption from ticlopidine, with positive lesional patch test" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C.M. García" 1 => "R. Carmena" 2 => "R. García" 3 => "P. Berges" 4 => "E. Camacho" 5 => "M.P. Cotter" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Contact Dermatitis" "fecha" => "2001" "volumen" => "44" "paginaInicial" => "40" "paginaFinal" => "41" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11156015" "web" => "Medline" ] ] ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bib46" "etiqueta" => "46." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Toxic erythroderma due to ticlopidine" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D.H. His" 1 => "D.J. Mock" 2 => "T.A. Rocco" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199904153401514" "Revista" => array:5 [ "tituloSerie" => "N Engl J Med" "fecha" => "1999" "volumen" => "340" "paginaInicial" => "1212" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10206848" "web" => "Medline" ] ] ] ] ] ] ] ] 46 => array:3 [ "identificador" => "bib47" "etiqueta" => "47." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Adverse cutaneous reactions to ticlopidine in patients with coronary stents" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "G. Yosipovitz" 1 => "E. Rechavia" 2 => "M. Feinmesser" 3 => "M. David" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "1999" "volumen" => "41" "paginaInicial" => "473" "paginaFinal" => "476" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10459126" "web" => "Medline" ] ] ] ] ] ] ] ] 47 => array:3 [ "identificador" => "bib48" "etiqueta" => "48." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lichen planus-type drug eruption resulting from ticlopidine" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "I. Kurokawa" 1 => "M. Umehara" 2 => "S. Nishijima" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-4632.2005.02277.x" "Revista" => array:6 [ "tituloSerie" => "Int J Dermatol" "fecha" => "2005" "volumen" => "44" "paginaInicial" => "437" "paginaFinal" => "438" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15869549" "web" => "Medline" ] ] ] ] ] ] ] ] 48 => array:3 [ "identificador" => "bib49" "etiqueta" => "49." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A paradoxical side-effect of antiaggregating treatment with ticlopidine: the Moschowitz syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "F. Fabris" 1 => "G. Luzzatto" 2 => "M.T. Sartori" 3 => "I. Zanella" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Haematologica" "fecha" => "1999" "volumen" => "84" "paginaInicial" => "760" "paginaFinal" => "762" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10457422" "web" => "Medline" ] ] ] ] ] ] ] ] 49 => array:3 [ "identificador" => "bib50" "etiqueta" => "50." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Thrombotic thrombocytopenic purpura associated with ticlopidine: a review of 60 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "C.L. Bennet" 1 => "P.D. Weinberg" 2 => "K. Rozenberg-Ben-Dor" 3 => "R.D. Yarnold" 4 => "H.C. Kwaan" 5 => "D. Green" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Ann Intern Med" "fecha" => "1998" "volumen" => "128" "paginaInicial" => "541" "paginaFinal" => "544" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9518398" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1552526010000166" "estado" => "S300" "issn" => "15525260" ] ] ] ] ] ] ] 50 => array:3 [ "identificador" => "bib51" "etiqueta" => "51." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Management of surgical patients receiving anticoagulation and antiplatelet agents" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. Thachil" 1 => "A. Gatt" 2 => "V. Martlew" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/bjs.6381" "Revista" => array:6 [ "tituloSerie" => "Br J Surg" "fecha" => "2008" "volumen" => "95" "paginaInicial" => "1437" "paginaFinal" => "1448" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18991253" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010000000001/v1_201304241446/S1578219009700046/v1_201304241446/en/main.assets" "Apartado" => array:4 [ "identificador" => "6224" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Review article" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010000000001/v1_201304241446/S1578219009700046/v1_201304241446/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009700046?idApp=UINPBA000044" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 3 | 5 | 8 |
| 2024 October | 71 | 63 | 134 |
| 2024 September | 73 | 56 | 129 |
| 2024 August | 94 | 76 | 170 |
| 2024 July | 80 | 59 | 139 |
| 2024 June | 70 | 60 | 130 |
| 2024 May | 71 | 62 | 133 |
| 2024 April | 65 | 45 | 110 |
| 2024 March | 56 | 54 | 110 |
| 2024 February | 47 | 51 | 98 |
| 2024 January | 44 | 69 | 113 |
| 2023 December | 43 | 96 | 139 |
| 2023 November | 41 | 94 | 135 |
| 2023 October | 47 | 61 | 108 |
| 2023 September | 36 | 62 | 98 |
| 2023 August | 27 | 45 | 72 |
| 2023 July | 39 | 93 | 132 |
| 2023 June | 37 | 55 | 92 |
| 2023 May | 39 | 78 | 117 |
| 2023 April | 26 | 70 | 96 |
| 2023 March | 33 | 62 | 95 |
| 2023 February | 29 | 50 | 79 |
| 2023 January | 29 | 65 | 94 |
| 2022 December | 32 | 57 | 89 |
| 2022 November | 15 | 44 | 59 |
| 2022 October | 12 | 39 | 51 |
| 2022 September | 14 | 57 | 71 |
| 2022 August | 19 | 47 | 66 |
| 2022 July | 12 | 54 | 66 |
| 2022 June | 16 | 58 | 74 |
| 2022 May | 22 | 68 | 90 |
| 2022 April | 24 | 78 | 102 |
| 2022 March | 28 | 79 | 107 |
| 2022 February | 19 | 76 | 95 |
| 2022 January | 27 | 67 | 94 |
| 2021 December | 44 | 62 | 106 |
| 2021 November | 32 | 70 | 102 |
| 2021 October | 28 | 77 | 105 |
| 2021 September | 25 | 83 | 108 |
| 2021 August | 24 | 57 | 81 |
| 2021 July | 55 | 42 | 97 |
| 2021 June | 26 | 60 | 86 |
| 2021 May | 40 | 57 | 97 |
| 2021 April | 65 | 106 | 171 |
| 2021 March | 73 | 43 | 116 |
| 2021 February | 67 | 57 | 124 |
| 2021 January | 52 | 28 | 80 |
| 2020 December | 23 | 31 | 54 |
| 2020 November | 37 | 28 | 65 |
| 2020 October | 38 | 23 | 61 |
| 2020 September | 15 | 19 | 34 |
| 2020 August | 30 | 35 | 65 |
| 2020 July | 43 | 33 | 76 |
| 2020 June | 23 | 37 | 60 |
| 2020 May | 25 | 36 | 61 |
| 2020 April | 34 | 29 | 63 |
| 2020 March | 24 | 42 | 66 |
| 2020 February | 1 | 17 | 18 |
| 2020 January | 0 | 37 | 37 |
| 2019 December | 0 | 38 | 38 |
| 2019 November | 0 | 19 | 19 |
| 2019 October | 0 | 22 | 22 |
| 2019 September | 0 | 9 | 9 |
| 2019 August | 0 | 9 | 9 |
| 2019 July | 0 | 17 | 17 |
| 2019 June | 0 | 10 | 10 |
| 2019 May | 0 | 48 | 48 |
| 2019 April | 0 | 15 | 15 |
| 2019 March | 0 | 3 | 3 |
| 2019 February | 0 | 11 | 11 |
| 2019 January | 0 | 2 | 2 |
| 2018 December | 0 | 2 | 2 |
| 2018 September | 0 | 12 | 12 |
| 2018 August | 0 | 22 | 22 |
| 2018 July | 0 | 16 | 16 |
| 2018 June | 0 | 12 | 12 |
| 2018 May | 0 | 8 | 8 |
| 2018 April | 0 | 9 | 9 |
| 2018 March | 0 | 10 | 10 |
| 2018 February | 8 | 23 | 31 |
| 2018 January | 14 | 20 | 34 |
| 2017 December | 12 | 20 | 32 |
| 2017 November | 15 | 24 | 39 |
| 2017 October | 14 | 22 | 36 |
| 2017 September | 12 | 33 | 45 |
| 2017 August | 25 | 22 | 47 |
| 2017 July | 11 | 31 | 42 |
| 2017 June | 16 | 47 | 63 |
| 2017 May | 18 | 24 | 42 |
| 2017 April | 24 | 21 | 45 |
| 2017 March | 41 | 47 | 88 |
| 2017 February | 12 | 16 | 28 |
| 2017 January | 13 | 13 | 26 |
| 2016 December | 23 | 12 | 35 |
| 2016 November | 28 | 29 | 57 |
| 2016 October | 25 | 28 | 53 |
| 2016 September | 28 | 25 | 53 |
| 2016 August | 32 | 35 | 67 |
| 2016 July | 22 | 11 | 33 |
| 2016 June | 7 | 10 | 17 |
| 2016 May | 6 | 10 | 16 |
| 2016 April | 7 | 10 | 17 |
| 2016 March | 7 | 11 | 18 |
| 2016 February | 10 | 12 | 22 |
| 2016 January | 13 | 10 | 23 |
| 2015 December | 7 | 10 | 17 |
| 2015 November | 16 | 12 | 28 |
| 2015 October | 11 | 16 | 27 |
| 2015 September | 6 | 2 | 8 |
| 2015 August | 18 | 5 | 23 |
| 2015 July | 32 | 31 | 63 |
| 2015 June | 31 | 25 | 56 |
| 2015 May | 56 | 33 | 89 |
| 2015 April | 28 | 36 | 64 |
| 2015 March | 33 | 39 | 72 |
| 2015 February | 15 | 22 | 37 |
| 2015 January | 17 | 30 | 47 |
| 2014 December | 26 | 28 | 54 |
| 2014 November | 21 | 35 | 56 |
| 2014 October | 30 | 24 | 54 |
| 2014 September | 23 | 23 | 46 |
| 2014 August | 48 | 27 | 75 |
| 2014 July | 41 | 25 | 66 |
| 2014 June | 46 | 11 | 57 |
| 2014 May | 39 | 18 | 57 |
| 2014 April | 27 | 17 | 44 |
| 2014 March | 38 | 25 | 63 |
| 2014 February | 32 | 27 | 59 |
| 2014 January | 26 | 27 | 53 |
| 2013 December | 27 | 22 | 49 |
| 2013 November | 26 | 24 | 50 |
| 2013 October | 33 | 21 | 54 |
| 2013 September | 32 | 26 | 58 |
| 2013 August | 27 | 35 | 62 |
| 2013 July | 27 | 35 | 62 |
| 2013 June | 26 | 38 | 64 |
| 2013 May | 22 | 35 | 57 |
| 2013 April | 22 | 40 | 62 |
| 2013 March | 37 | 26 | 63 |
| 2013 February | 36 | 14 | 50 |
| 2013 January | 11 | 5 | 16 |
Show all
