Case reports
Two Cases of Eruptive Pyoderma Gangrenosum Associated with Cocaine Use
Piodermas Gangrenosos Eruptivos Asociados al Consumo de Cocaína Inhalada. Presentación de dos Casos
E. Roche
, T. Martínez-Menchón, J.L. Sánchez-Carazo, V. Oliver, V. Alegre de Miquel
Corresponding author
erochega@yahoo.es
Correspondence: Hospital General Universitario de Valencia, Servicio de Dermatología, Avda. Tres Cruces s/n, 46014 Valencia, Spain.
Correspondence: Hospital General Universitario de Valencia, Servicio de Dermatología, Avda. Tres Cruces s/n, 46014 Valencia, Spain.
Departamento de Dermatología, Hospital General Universitario de Valencia, Valencia, Spain
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"apellidos" => "Roche" "email" => array:1 [ 0 => "erochega@yahoo.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:2 [ "nombre" => "T." "apellidos" => "Martínez-Menchón" ] 2 => array:2 [ "nombre" => "J.L." "apellidos" => "Sánchez-Carazo" ] 3 => array:2 [ "nombre" => "V." "apellidos" => "Oliver" ] 4 => array:2 [ "nombre" => "V." "apellidos" => "Alegre de Miquel" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Departamento de Dermatología, Hospital General Universitario de Valencia, Valencia, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Hospital General Universitario de Valencia, Servicio de Dermatología, Avda. Tres Cruces s/n, 46014 Valencia, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Piodermas Gangrenosos Eruptivos Asociados al Consumo de Cocaína Inhalada. Presentación de dos Casos" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2007-09-19" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84306" "palabras" => array:3 [ 0 => "pyoderma gangrenosum" 1 => "cocaine" 2 => "infliximab" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84305" "palabras" => array:3 [ 0 => "pioderma gangrenoso" 1 => "cocaína" 2 => "infliximab" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">We present the cases of 2 regular cocaine users aged 30 and 37 years who developed a cutaneous condition with an identical presentation and a similar clinical course. The lesions first appeared as eruptions on the back and then spread to other parts of the body. They consisted of painful inflammatory nodules that developed into abscesses and ulcers that grew outwards. They had a granulomatous base and irregular violaceous edges. The results of histopathologic studies were compatible with the clinical diagnosis of pyoderma gangrenosum, and additional tests ruled out underlying diseases. After several therapeutic failures with usual treatments, the patients responded quickly to infliximab after interrupting their cocaine consumption. The association between pyoderma gangrenosum and cocaine use was clear as both suffered clinical relapses at the same time as they started using the drug again.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Presentamos los casos de dos pacientes varones, de 30 y 37 años, consumidores habituales de cocaína inhalada, que desarrollaron un cuadro cutáneo de idéntica presentación y evolución clínica. Las lesiones se iniciaban de forma eruptiva en la espalda y posteriormente se generalizaban. Consistían en nódulos inflamatorios y dolorosos, que evolucionaban hasta abscesos y úlceras de crecimiento centrífugo, fondo granulomatoso y bordes violáceos e irregulares. Los estudios histopatológicos fueron compatibles con los diagnósticos clínicos de piodermas gangrenosos (PG) y las exploraciones complementarias realizadas descartaron patologías subyacentes. Tras varios fracasos terapéuticos con terapias clásicas, respondieron rápidamente a infliximab asociado a deshabituación de cocaína. La asociación de PG con el consumo de cocaína quedó patente, ya que ambos mostraron recidivas clínicas simultáneamente con recaídas en su adicción.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:15 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| 2022 November | 14 | 31 | 45 |
| 2022 October | 17 | 19 | 36 |
| 2022 September | 24 | 31 | 55 |
| 2022 August | 13 | 36 | 49 |
| 2022 July | 12 | 28 | 40 |
| 2022 June | 13 | 31 | 44 |
| 2022 May | 32 | 45 | 77 |
| 2022 April | 29 | 41 | 70 |
| 2022 March | 29 | 62 | 91 |
| 2022 February | 22 | 33 | 55 |
| 2022 January | 34 | 35 | 69 |
| 2021 December | 33 | 48 | 81 |
| 2021 November | 33 | 36 | 69 |
| 2021 October | 30 | 48 | 78 |
| 2021 September | 32 | 39 | 71 |
| 2021 August | 24 | 22 | 46 |
| 2021 July | 27 | 32 | 59 |
| 2021 June | 38 | 36 | 74 |
| 2021 May | 44 | 32 | 76 |
| 2021 April | 63 | 71 | 134 |
| 2021 March | 73 | 23 | 96 |
| 2021 February | 81 | 30 | 111 |
| 2021 January | 51 | 20 | 71 |
| 2020 December | 30 | 18 | 48 |
| 2020 November | 29 | 26 | 55 |
| 2020 October | 48 | 16 | 64 |
| 2020 September | 32 | 18 | 50 |
| 2020 August | 27 | 15 | 42 |
| 2020 July | 19 | 13 | 32 |
| 2020 June | 25 | 28 | 53 |
| 2020 May | 26 | 22 | 48 |
| 2020 April | 18 | 25 | 43 |
| 2020 March | 26 | 24 | 50 |
| 2020 February | 4 | 9 | 13 |
| 2020 January | 0 | 10 | 10 |
| 2019 December | 0 | 13 | 13 |
| 2019 November | 0 | 4 | 4 |
| 2019 October | 0 | 16 | 16 |
| 2019 September | 0 | 8 | 8 |
| 2019 August | 0 | 9 | 9 |
| 2019 July | 0 | 19 | 19 |
| 2019 June | 0 | 22 | 22 |
| 2019 May | 0 | 69 | 69 |
| 2019 April | 0 | 37 | 37 |
| 2019 March | 0 | 5 | 5 |
| 2019 February | 0 | 12 | 12 |
| 2019 January | 0 | 4 | 4 |
| 2018 December | 0 | 2 | 2 |
| 2018 November | 0 | 4 | 4 |
| 2018 October | 0 | 2 | 2 |
| 2018 September | 0 | 3 | 3 |
| 2018 August | 0 | 14 | 14 |
| 2018 July | 0 | 16 | 16 |
| 2018 June | 0 | 10 | 10 |
| 2018 May | 0 | 8 | 8 |
| 2018 April | 0 | 14 | 14 |
| 2018 March | 0 | 2 | 2 |
| 2018 February | 6 | 11 | 17 |
| 2018 January | 15 | 10 | 25 |
| 2017 December | 11 | 11 | 22 |
| 2017 November | 10 | 15 | 25 |
| 2017 October | 13 | 9 | 22 |
| 2017 September | 12 | 17 | 29 |
| 2017 August | 14 | 14 | 28 |
| 2017 July | 8 | 16 | 24 |
| 2017 June | 13 | 20 | 33 |
| 2017 May | 12 | 18 | 30 |
| 2017 April | 18 | 10 | 28 |
| 2017 March | 18 | 73 | 91 |
| 2017 February | 12 | 9 | 21 |
| 2017 January | 9 | 15 | 24 |
| 2016 December | 26 | 12 | 38 |
| 2016 November | 25 | 18 | 43 |
| 2016 October | 31 | 21 | 52 |
| 2016 September | 35 | 10 | 45 |
| 2016 August | 44 | 19 | 63 |
| 2016 July | 19 | 4 | 23 |
| 2016 June | 8 | 8 | 16 |
| 2016 May | 7 | 6 | 13 |
| 2016 April | 9 | 9 | 18 |
| 2016 March | 5 | 8 | 13 |
| 2016 February | 8 | 13 | 21 |
| 2016 January | 5 | 10 | 15 |
| 2015 December | 8 | 10 | 18 |
| 2015 November | 12 | 5 | 17 |
| 2015 October | 7 | 8 | 15 |
| 2015 September | 3 | 5 | 8 |
| 2015 August | 11 | 2 | 13 |
| 2015 July | 30 | 13 | 43 |
| 2015 June | 19 | 13 | 32 |
| 2015 May | 71 | 23 | 94 |
| 2015 April | 40 | 12 | 52 |
| 2015 March | 26 | 12 | 38 |
| 2015 February | 22 | 12 | 34 |
| 2015 January | 23 | 12 | 35 |
| 2014 December | 24 | 18 | 42 |
| 2014 November | 26 | 19 | 45 |
| 2014 October | 39 | 10 | 49 |
| 2014 September | 29 | 10 | 39 |
| 2014 August | 35 | 18 | 53 |
| 2014 July | 56 | 15 | 71 |
| 2014 June | 44 | 8 | 52 |
| 2014 May | 35 | 14 | 49 |
| 2014 April | 35 | 7 | 42 |
| 2014 March | 36 | 18 | 54 |
| 2014 February | 22 | 20 | 42 |
| 2014 January | 29 | 16 | 45 |
| 2013 December | 34 | 13 | 47 |
| 2013 November | 29 | 24 | 53 |
| 2013 October | 29 | 15 | 44 |
| 2013 September | 33 | 27 | 60 |
| 2013 August | 32 | 27 | 59 |
| 2013 July | 32 | 30 | 62 |
| 2013 June | 24 | 21 | 45 |
| 2013 May | 26 | 25 | 51 |
| 2013 April | 26 | 19 | 45 |
| 2013 March | 28 | 30 | 58 |
| 2013 February | 26 | 10 | 36 |
| 2013 January | 16 | 5 | 21 |
Show all
