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Effector Function of CLA+ T Lymphocytes on Autologous Keratinocytes in Psoriasis
Función Efectora de Linfocitos T CLA1 Sobre Queratinocitos Autólogos en Psoriasis
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Conde-Taboada, F.J. González-Barcala, J. Toribio" "autores" => array:3 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Conde-Taboada" ] 1 => array:2 [ "nombre" => "F.J." "apellidos" => "González-Barcala" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "Toribio" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219008703457?idApp=UINPBA000044" "url" => "/15782190/0000009900000009/v1_201304241441/S1578219008703457/v1_201304241441/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original articles</span>" "titulo" => "Effector Function of CLA+ T Lymphocytes on Autologous Keratinocytes in Psoriasis" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "701" "paginaFinal" => "707" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "M. Ferran, A.M. Giménez-Arnau, B. Bellosillo, R.M. Pujol, L.F. Santamaría-Babi" "autores" => array:5 [ 0 => array:4 [ "nombre" => "M." "apellidos" => "Ferran" "email" => array:1 [ 0 => "mferran@imas.imim.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "A.M." "apellidos" => "Giménez-Arnau" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 2 => array:3 [ "nombre" => "B." "apellidos" => "Bellosillo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 3 => array:3 [ "nombre" => "R.M." "apellidos" => "Pujol" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 4 => array:3 [ "nombre" => "L.F." "apellidos" => "Santamaría-Babi" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital del Mar-IMAS/IMIM, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Hospital del Mar-IMAS/IMIM, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Servicio de Dermatología, Hospital del Mar, Passeig Marítim, 25-29, 08003 Barcelona, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Función Efectora de Linfocitos T CLA1 Sobre Queratinocitos Autólogos en Psoriasis" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2008-02-27" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84316" "palabras" => array:4 [ 0 => "psoriasis" 1 => "cutaneous lymphocyte antigen" 2 => "keratinocyte" 3 => "inducible nitric oxide synthase" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84315" "palabras" => array:5 [ 0 => "psoriasis" 1 => "antígeno linfocitario cutáneo" 2 => "CLA" 3 => "queratinocito" 4 => "iNOS" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p class="elsevierStyleSimplePara elsevierViewall">Cutaneous lymphocyte antigen (CLA) is expressed by a subgroup of memory T cells that exhibit skin homing and are implicated in cutaneous T-cell-mediated diseases.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">Expression of genes associated with psoriasis was analyzed in keratinocytes taken from patients and healthy individuals and cultured under different conditions, including activation using supernatants from CLA<span class="elsevierStyleSup">+</span> T lymphocytes activated with anti-CD3 and anti-CD28 antibodies.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Keratinocytes from psoriasis patients activated by CLA<span class="elsevierStyleSup">+</span> T lymphocytes expressed higher levels of interferon-inducible protein 10, HLA-DR, intercellular cell adhesion molecule 1, and inducible nitric oxide synthase.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Our results suggest that we have developed an in vitro model that will allow analysis of the effector role of CLA<span class="elsevierStyleSup">+</span> T lymphocytes on keratinocytes in psoriasis. This model may allow the identification of genes involved in the pathology of psoriasis through induction by CLA<span class="elsevierStyleSup">+</span> T lymphocytes.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p class="elsevierStyleSimplePara elsevierViewall">Los linfocitos T CLA+ representan un subgrupo de linfocitos T de memoria con tropismo cutáneo que están implicados en diferentes enfermedades cutáneas mediadas por células T.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Se estudió la expresión de algunos genes asociados a la psoriasis en queratinocitos de enfermos y sanos cultivados en diferentes condiciones, entre ellas la activación por sobrenadantes de linfocitos T CLA+ activados mediante anti-CD3/anti-CD28.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Los queratinocitos psoriásicos activados por linfocitos CLA+ expresan más IP-10, HLA-DR, ICAM-1 e iNOS.</p> <span class="elsevierStyleSectionTitle">Discusión</span><p class="elsevierStyleSimplePara elsevierViewall">Estos resultados sugieren que hemos establecido un modelo <span class="elsevierStyleItalic">in vitro</span> que permite estudiar la función efectora de los linfocitos T CLA+ sobre los queratinocitos en la psoriasis. Este modelo puede permitir la identificación de genes relevantes en la patogenia de la psoriasis al ser inducidos por linfocitos T CLA+.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Study financed by an award from Fundation Salud 2000 for study of clinical immunology of psoriasis (2003).</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:39 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "CLA (+) T cells in cutaneous diseases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "L.F. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 5 | 8 | 13 |
| 2024 October | 69 | 61 | 130 |
| 2024 September | 63 | 31 | 94 |
| 2024 August | 93 | 56 | 149 |
| 2024 July | 63 | 30 | 93 |
| 2024 June | 54 | 24 | 78 |
| 2024 May | 52 | 31 | 83 |
| 2024 April | 43 | 22 | 65 |
| 2024 March | 61 | 48 | 109 |
| 2024 February | 64 | 40 | 104 |
| 2024 January | 44 | 37 | 81 |
| 2023 December | 43 | 31 | 74 |
| 2023 November | 39 | 36 | 75 |
| 2023 October | 32 | 19 | 51 |
| 2023 September | 32 | 30 | 62 |
| 2023 August | 26 | 18 | 44 |
| 2023 July | 34 | 40 | 74 |
| 2023 June | 46 | 22 | 68 |
| 2023 May | 37 | 27 | 64 |
| 2023 April | 26 | 17 | 43 |
| 2023 March | 19 | 23 | 42 |
| 2023 February | 39 | 22 | 61 |
| 2023 January | 22 | 27 | 49 |
| 2022 December | 28 | 32 | 60 |
| 2022 November | 15 | 22 | 37 |
| 2022 October | 16 | 19 | 35 |
| 2022 September | 15 | 36 | 51 |
| 2022 August | 19 | 42 | 61 |
| 2022 July | 13 | 28 | 41 |
| 2022 June | 17 | 31 | 48 |
| 2022 May | 21 | 41 | 62 |
| 2022 April | 35 | 39 | 74 |
| 2022 March | 49 | 62 | 111 |
| 2022 February | 19 | 32 | 51 |
| 2022 January | 21 | 38 | 59 |
| 2021 December | 45 | 46 | 91 |
| 2021 November | 24 | 48 | 72 |
| 2021 October | 24 | 55 | 79 |
| 2021 September | 18 | 39 | 57 |
| 2021 August | 26 | 35 | 61 |
| 2021 July | 25 | 30 | 55 |
| 2021 June | 14 | 36 | 50 |
| 2021 May | 33 | 40 | 73 |
| 2021 April | 58 | 58 | 116 |
| 2021 March | 65 | 39 | 104 |
| 2021 February | 31 | 24 | 55 |
| 2021 January | 22 | 25 | 47 |
| 2020 December | 14 | 18 | 32 |
| 2020 November | 18 | 15 | 33 |
| 2020 October | 22 | 10 | 32 |
| 2020 September | 33 | 12 | 45 |
| 2020 August | 30 | 27 | 57 |
| 2020 July | 32 | 17 | 49 |
| 2020 June | 26 | 12 | 38 |
| 2020 May | 28 | 14 | 42 |
| 2020 April | 12 | 24 | 36 |
| 2020 March | 17 | 16 | 33 |
| 2020 February | 2 | 7 | 9 |
| 2020 January | 0 | 10 | 10 |
| 2019 December | 0 | 2 | 2 |
| 2019 November | 0 | 1 | 1 |
| 2019 October | 0 | 1 | 1 |
| 2019 September | 0 | 2 | 2 |
| 2019 August | 0 | 1 | 1 |
| 2019 July | 0 | 4 | 4 |
| 2019 June | 0 | 3 | 3 |
| 2019 May | 0 | 48 | 48 |
| 2019 April | 0 | 4 | 4 |
| 2019 March | 0 | 2 | 2 |
| 2019 February | 0 | 2 | 2 |
| 2018 December | 1 | 0 | 1 |
| 2018 November | 0 | 1 | 1 |
| 2018 October | 0 | 1 | 1 |
| 2018 September | 1 | 0 | 1 |
| 2018 February | 9 | 5 | 14 |
| 2018 January | 17 | 5 | 22 |
| 2017 December | 16 | 8 | 24 |
| 2017 November | 12 | 4 | 16 |
| 2017 October | 20 | 6 | 26 |
| 2017 September | 14 | 2 | 16 |
| 2017 August | 19 | 4 | 23 |
| 2017 July | 17 | 6 | 23 |
| 2017 June | 25 | 5 | 30 |
| 2017 May | 28 | 4 | 32 |
| 2017 April | 27 | 19 | 46 |
| 2017 March | 27 | 9 | 36 |
| 2017 February | 17 | 4 | 21 |
| 2017 January | 10 | 8 | 18 |
| 2016 December | 31 | 4 | 35 |
| 2016 November | 23 | 10 | 33 |
| 2016 October | 29 | 24 | 53 |
| 2016 September | 31 | 5 | 36 |
| 2016 August | 34 | 14 | 48 |
| 2016 July | 23 | 8 | 31 |
| 2016 June | 16 | 3 | 19 |
| 2016 May | 7 | 7 | 14 |
| 2016 April | 6 | 6 | 12 |
| 2016 March | 5 | 8 | 13 |
| 2016 February | 6 | 12 | 18 |
| 2016 January | 5 | 13 | 18 |
| 2015 December | 12 | 5 | 17 |
| 2015 November | 17 | 1 | 18 |
| 2015 October | 10 | 12 | 22 |
| 2015 September | 2 | 5 | 7 |
| 2015 August | 23 | 3 | 26 |
| 2015 July | 36 | 20 | 56 |
| 2015 June | 43 | 20 | 63 |
| 2015 May | 75 | 27 | 102 |
| 2015 April | 39 | 25 | 64 |
| 2015 March | 53 | 19 | 72 |
| 2015 February | 28 | 39 | 67 |
| 2015 January | 21 | 41 | 62 |
| 2014 December | 29 | 38 | 67 |
| 2014 November | 24 | 25 | 49 |
| 2014 October | 31 | 32 | 63 |
| 2014 September | 27 | 23 | 50 |
| 2014 August | 50 | 16 | 66 |
| 2014 July | 47 | 25 | 72 |
| 2014 June | 37 | 16 | 53 |
| 2014 May | 42 | 15 | 57 |
| 2014 April | 31 | 14 | 45 |
| 2014 March | 38 | 17 | 55 |
| 2014 February | 25 | 23 | 48 |
| 2014 January | 29 | 21 | 50 |
| 2013 December | 36 | 14 | 50 |
| 2013 November | 34 | 16 | 50 |
| 2013 October | 40 | 20 | 60 |
| 2013 September | 31 | 29 | 60 |
| 2013 August | 33 | 30 | 63 |
| 2013 July | 35 | 48 | 83 |
| 2013 June | 35 | 44 | 79 |
| 2013 May | 37 | 28 | 65 |
| 2013 April | 27 | 33 | 60 |
| 2013 March | 29 | 34 | 63 |
| 2013 February | 29 | 11 | 40 |
| 2013 January | 19 | 7 | 26 |
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