Advances in dermatology
Clinical Applications of Reflectance Confocal Microscopy in the Management of Cutaneous Tumors
Aplicaciones Clínicas de la Microscopía Confocal de Reflectancia en el Manejo de Los Tumores Cutáneos
S. González
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gonzals6@mskcc.org
Correspondence: Dermatology Service, Memorial Sloan-Kettering Cancer Center, 160 E 53rd Street, New York, NY10022, USA.
Correspondence: Dermatology Service, Memorial Sloan-Kettering Cancer Center, 160 E 53rd Street, New York, NY10022, USA.
Dermatology Service. Memorial Sloan-Kettering Cancer Center, New York, USA Servicio de Dermatología. Hospital Ramón y Cajal, Madrid, Spain
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García Franco, A. España" "autores" => array:2 [ 0 => array:2 [ "nombre" => "C.E." "apellidos" => "García Franco" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "España" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219008703081?idApp=UINPBA000044" "url" => "/15782190/0000009900000007/v1_201304241437/S1578219008703081/v1_201304241437/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Advances in dermatology</span>" "titulo" => "Clinical Applications of Reflectance Confocal Microscopy in the Management of Cutaneous Tumors" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "528" "paginaFinal" => "531" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "S. González" "autores" => array:1 [ 0 => array:4 [ "nombre" => "S." "apellidos" => "González" "email" => array:1 [ 0 => "gonzals6@mskcc.org" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Dermatology Service. Memorial Sloan-Kettering Cancer Center, New York, USA Servicio de Dermatología. Hospital Ramón y Cajal, Madrid, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Dermatology Service, Memorial Sloan-Kettering Cancer Center, 160 E 53rd Street, New York, NY10022, USA." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Aplicaciones Clínicas de la Microscopía Confocal de Reflectancia en el Manejo de Los Tumores Cutáneos" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2007-12-09" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84251" "palabras" => array:4 [ 0 => "reflectance confocal microscopy" 1 => "cutaneous tumors" 2 => "virtual biopsy" 3 => "noninvasive technology" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84252" "palabras" => array:4 [ 0 => "microscopía confocal de reflectancia" 1 => "tumores cutáneos" 2 => "biopsia virtual" 3 => "tecnología no invasiva" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Reflectance confocal microscopy is a noninvasive tool that allows skin cells and structure to be imaged in real time. The technique has been used to assess benign and malignant lesions and has shown great potential in basic research and clinical dermatology. As might be expected, it also has great potential in longitudinal clinical studies and in the evaluation of dynamic processes such as those that occur after exposure to UV radiation or during the tumor response to noninvasive therapy. This article briefly describes the fundamental aspects and basic principles of reflectance confocal microscopy and discusses its clinical applications essentially in the management of cutaneous tumors. We also consider the limitations of the technique associated with the optical properties of the skin, with instrumentation, and with interpretation of the images.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">La microscopía confocal de reflectancia es una herramienta de imágenes que permite la visualización de células y estructuras de la piel de forma no invasiva y en tiempo real. Ésta se ha usado para la evaluación de lesiones benignas y malignas, demostrando un gran potencial para aplicaciones en investigación básica y en dermatología clínica. Como cabría pensar, esta tecnología tiene un gran potencial en estudios clínicos longitudinales y en la evaluación de procesos dinámicos como los que acontecen tras la exposición a radiación ultravioleta o durante la respuesta de los tumores a terapias no invasivas. Este artículo discute brevemente los fundamentos o principios básicos de la microscopía confocal de reflectancia, sus aplicaciones clínicas, fundamentalmente en el manejo de los tumores cutáneos, y las limitaciones que la técnica presenta asociadas a las propiedades ópticas de la piel, con la instrumentación y con la interpretación de las imágenes.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:23 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "In vivo optical coherence tomography imaging of human skin: norm and pathology" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N.D. Gladkova" 1 => "G.A. Petrova" 2 => "N.K. Nikulin" 3 => "S.G. Radenska-Lopovok" 4 => "L.B. Snopova" 5 => "Y.P. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 0 | 1 | 1 |
| 2024 October | 71 | 48 | 119 |
| 2024 September | 70 | 44 | 114 |
| 2024 August | 103 | 69 | 172 |
| 2024 July | 59 | 30 | 89 |
| 2024 June | 51 | 38 | 89 |
| 2024 May | 49 | 29 | 78 |
| 2024 April | 43 | 32 | 75 |
| 2024 March | 52 | 27 | 79 |
| 2024 February | 40 | 39 | 79 |
| 2024 January | 26 | 43 | 69 |
| 2023 December | 34 | 29 | 63 |
| 2023 November | 22 | 34 | 56 |
| 2023 October | 29 | 31 | 60 |
| 2023 September | 27 | 19 | 46 |
| 2023 August | 19 | 16 | 35 |
| 2023 July | 21 | 46 | 67 |
| 2023 June | 40 | 81 | 121 |
| 2023 May | 25 | 22 | 47 |
| 2023 April | 23 | 27 | 50 |
| 2023 March | 19 | 24 | 43 |
| 2023 February | 17 | 21 | 38 |
| 2023 January | 16 | 18 | 34 |
| 2022 December | 28 | 35 | 63 |
| 2022 November | 17 | 25 | 42 |
| 2022 October | 18 | 21 | 39 |
| 2022 September | 15 | 39 | 54 |
| 2022 August | 14 | 40 | 54 |
| 2022 July | 11 | 31 | 42 |
| 2022 June | 12 | 31 | 43 |
| 2022 May | 34 | 39 | 73 |
| 2022 April | 34 | 39 | 73 |
| 2022 March | 37 | 58 | 95 |
| 2022 February | 26 | 29 | 55 |
| 2022 January | 13 | 32 | 45 |
| 2021 December | 30 | 43 | 73 |
| 2021 November | 29 | 39 | 68 |
| 2021 October | 21 | 42 | 63 |
| 2021 September | 22 | 37 | 59 |
| 2021 August | 21 | 21 | 42 |
| 2021 July | 31 | 27 | 58 |
| 2021 June | 38 | 43 | 81 |
| 2021 May | 24 | 29 | 53 |
| 2021 April | 18 | 46 | 64 |
| 2021 March | 53 | 27 | 80 |
| 2021 February | 47 | 24 | 71 |
| 2021 January | 19 | 19 | 38 |
| 2020 December | 29 | 10 | 39 |
| 2020 November | 27 | 18 | 45 |
| 2020 October | 14 | 2 | 16 |
| 2020 September | 17 | 10 | 27 |
| 2020 August | 25 | 20 | 45 |
| 2020 July | 22 | 13 | 35 |
| 2020 June | 17 | 18 | 35 |
| 2020 May | 21 | 16 | 37 |
| 2020 April | 19 | 16 | 35 |
| 2020 March | 19 | 19 | 38 |
| 2020 January | 0 | 5 | 5 |
| 2019 December | 0 | 8 | 8 |
| 2019 November | 0 | 3 | 3 |
| 2019 October | 0 | 2 | 2 |
| 2019 September | 0 | 3 | 3 |
| 2019 August | 0 | 3 | 3 |
| 2019 July | 0 | 5 | 5 |
| 2019 June | 0 | 11 | 11 |
| 2019 May | 0 | 64 | 64 |
| 2019 April | 0 | 6 | 6 |
| 2019 March | 0 | 5 | 5 |
| 2018 July | 0 | 4 | 4 |
| 2018 June | 0 | 3 | 3 |
| 2018 May | 0 | 5 | 5 |
| 2018 April | 0 | 6 | 6 |
| 2018 March | 0 | 2 | 2 |
| 2018 February | 14 | 8 | 22 |
| 2018 January | 14 | 11 | 25 |
| 2017 December | 17 | 15 | 32 |
| 2017 November | 12 | 19 | 31 |
| 2017 October | 9 | 4 | 13 |
| 2017 September | 15 | 11 | 26 |
| 2017 August | 22 | 14 | 36 |
| 2017 July | 21 | 10 | 31 |
| 2017 June | 30 | 18 | 48 |
| 2017 May | 15 | 20 | 35 |
| 2017 April | 14 | 30 | 44 |
| 2017 March | 16 | 11 | 27 |
| 2017 February | 15 | 22 | 37 |
| 2017 January | 9 | 10 | 19 |
| 2016 December | 22 | 20 | 42 |
| 2016 November | 26 | 11 | 37 |
| 2016 October | 21 | 22 | 43 |
| 2016 September | 28 | 23 | 51 |
| 2016 August | 21 | 4 | 25 |
| 2016 July | 20 | 6 | 26 |
| 2016 June | 13 | 10 | 23 |
| 2016 May | 5 | 4 | 9 |
| 2016 April | 11 | 11 | 22 |
| 2016 March | 5 | 11 | 16 |
| 2016 February | 10 | 12 | 22 |
| 2016 January | 12 | 16 | 28 |
| 2015 December | 8 | 13 | 21 |
| 2015 November | 11 | 12 | 23 |
| 2015 October | 8 | 11 | 19 |
| 2015 September | 10 | 4 | 14 |
| 2015 August | 13 | 2 | 15 |
| 2015 July | 22 | 10 | 32 |
| 2015 June | 25 | 11 | 36 |
| 2015 May | 65 | 24 | 89 |
| 2015 April | 22 | 20 | 42 |
| 2015 March | 22 | 11 | 33 |
| 2015 February | 24 | 23 | 47 |
| 2015 January | 12 | 14 | 26 |
| 2014 December | 20 | 13 | 33 |
| 2014 November | 14 | 22 | 36 |
| 2014 October | 29 | 25 | 54 |
| 2014 September | 24 | 17 | 41 |
| 2014 August | 25 | 22 | 47 |
| 2014 July | 31 | 25 | 56 |
| 2014 June | 33 | 16 | 49 |
| 2014 May | 30 | 22 | 52 |
| 2014 April | 32 | 9 | 41 |
| 2014 March | 38 | 21 | 59 |
| 2014 February | 24 | 26 | 50 |
| 2014 January | 33 | 17 | 50 |
| 2013 December | 34 | 17 | 51 |
| 2013 November | 27 | 23 | 50 |
| 2013 October | 27 | 24 | 51 |
| 2013 September | 27 | 25 | 52 |
| 2013 August | 36 | 25 | 61 |
| 2013 July | 35 | 26 | 61 |
| 2013 June | 26 | 22 | 48 |
| 2013 May | 29 | 17 | 46 |
| 2013 April | 16 | 16 | 32 |
| 2013 March | 24 | 35 | 59 |
| 2013 February | 32 | 12 | 44 |
| 2013 January | 16 | 6 | 22 |
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