Correspondence: Servicio de Dermatología, Hospital Ramón y Cajal Universidad de Alcalá de Henares, Carretera de Colmenar Viejo, km 9,400, 28034 Madrid, Spain.
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Harto-Castaño, P. Jaén-Olasolo" "autores" => array:6 [ 0 => array:4 [ "nombre" => "S." "apellidos" => "Aboín-González" "email" => array:1 [ 0 => "asonsoles@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "I." "apellidos" => "Aldanondo-Fernández de la Mora" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 2 => array:3 [ "nombre" => "C.R." "apellidos" => "García-Acebes" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 3 => array:3 [ "nombre" => "R." 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"apellidos" => "Jaén-Olasolo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital Ramón y Cajal, Universidad de Alcalá de Henares, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Hospital Ramón y Cajal, Universidad de Alcalá de Henares, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Servicio de Dermatología, Hospital Ramón y Cajal Universidad de Alcalá de Henares, Carretera de Colmenar Viejo, km 9,400, 28034 Madrid, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Síndrome Cinca: Presentación de un Caso Con Exacerbación Febril de Sus Lesiones Cutáneas" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2007-12-12" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84233" "palabras" => array:4 [ 0 => "chronic infantile neurologic cutaneous and articular syndrome" 1 => "neonatal onset multi-inflammatory disease" 2 => "neutrophilic dermatitis" 3 => "cryopyrin" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84234" "palabras" => array:4 [ 0 => "CINCA (<span class="elsevierStyleItalic">Chronic Infantile Neurologic Cutaneous Articular Syndrome</span>)" 1 => "NOMID (<span class="elsevierStyleItalic">Neonatal Onset Multi-Inflammatory Disease</span>)" 2 => "dermatitis neutrofílica" 3 => "criopirina" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Chronic infantile neurologic cutaneous articular (CINCA) syndrome is a serious chronic systemic inflammatory disease that presents at a young age and that is characterized by skin, joint, and central nervous system disease. Skin symptoms are the first to appear, in the form of a longstanding nonpruritic urticarial rash, with exacerbations coinciding with episodes of fever, arthritis, and enlarged lymph nodes. The findings of biopsy of skin lesions are extremely variable but characterized by perivascular neutrophilic infiltrate. With the discovery of mutations in the <span class="elsevierStyleItalic">CIAS1</span> gene, which encodes a protein known as cryopyrin, this entity has been classified as one of the cryopyrin-associated autoinflammatory diseases, along with familial cold urticaria and Muckle-Wells syndrome. This discovery has also made available new therapeutic options. We present the case of a boy diagnosed with CINCA syndrome who presented with an outbreak of painful skin lesions and fever. These lesions were thought to be an exacerbation of underlying lesions during an episode of fever.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">El síndrome CINCA (<span class="elsevierStyleItalic">Chronic Infantile Neurologic Cutaneous Articular Syndrome</span>) es una grave enfermedad inflamatoria sistémica crónica, de instauración temprana, que se caracteriza por afectación cutánea, articular y del sistema nervioso central (SNC). La clínica cutánea en forma de exantema urticariforme no pruriginoso es la primera en aparecer, siendo más o menos permanente con exacerbaciones que coinciden con brotes de fiebre, artritis y adenopatías. La biopsia de las lesiones cutáneas es muy variable, aunque destaca un infiltrado neutrofílico perivascular. El descubrimiento de mutaciones en el gen CIAS1, que codifica una proteína llamada criopirina, ha permitido añadir esta entidad al espectro de las enfermedades autoinflamatorias asociadas a criopirinas, junto con la urticaria familiar por frío y el síndrome de Muckle-Wells, implicando además nuevas opciones terapéuticas. Presentamos el caso de un varón diagnosticado de síndrome CINCA que presentó un brote de lesiones cutáneas dolorosas y fiebre, interpretándose éstas como una exacerbación de sus lesiones habituales durante un episodio febril.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:17 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A chronic infantile, neurological, cutaneous and articular (CINCA) syndrome. A specific entity analysed in 30 patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A.M. Prieur" 1 => "C. Griscelli" 2 => "F. Lampert" 3 => "H. Truckenbrodt" 4 => "M.A. Guggenheim" 5 => "D.J. Lovell" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Scand J Rheumatol Suppl" "fecha" => "1987" "volumen" => "66" "paginaInicial" => "57" "paginaFinal" => "68" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3482735" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fiebre periódica" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "F.I. Mongil" 1 => "V. Canduela" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "An Esp Pediatr" "fecha" => "2002" "volumen" => "57" "paginaInicial" => "334" "paginaFinal" => "344" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12392668" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A recently recognized chronic inflammatory disease of early onset characterized by the triad of rash, central nervous system involvement and arthropathy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A.M. Prieur" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Exp Rheumatol" "fecha" => "2001" "volumen" => "19" "paginaInicial" => "403" "paginaFinal" => "406" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11491495" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Feldmann" 1 => "A.M. Prieur" 2 => "P. Quartier" 3 => "P. Berquin" 4 => "S. Certain" 5 => "E. Cortis" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Hum Genet" "fecha" => "2002" "volumen" => "71" "paginaInicial" => "198" "paginaFinal" => "203" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12032915" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "De novo CIAS1 mutations cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "I. Aksentijevich" 1 => "M. Nowak" 2 => "M. Mallah" 3 => "J.J. Chae" 4 => "W.T. Watford" 5 => "S.R. Hofmann" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/art.10688" "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "2002" "volumen" => "46" "paginaInicial" => "3340" "paginaFinal" => "3348" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12483741" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Arthropathy with rash, chronic meningitis, eye lesions and mental retardation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A.M. Prieur" 1 => "C. Griscelli" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Pediatr" "fecha" => "1981" "volumen" => "99" "paginaInicial" => "79" "paginaFinal" => "83" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7252669" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neonatal onset multisystem inflammatory disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S.G. Hassink" 1 => "D.P. Goldsmith" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "1983" "volumen" => "26" "paginaInicial" => "668" "paginaFinal" => "673" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6847730" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chronic infantile neurological cutaneous articular syndrome: CD10 over expression in neutrophils is a possible key to the pathogenesis of the disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "V. Leone" 1 => "G. Presani" 2 => "S. Perticarari" 3 => "A. Tommasini" 4 => "S. Crovella" 5 => "A. Lenhardt" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00431-003-1284-x" "Revista" => array:6 [ "tituloSerie" => "Eur J Pediatr" "fecha" => "2003" "volumen" => "162" "paginaInicial" => "669" "paginaFinal" => "673" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12928894" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The CINCA syndrome: a rare cause of chronic arthritis and multisystem inflammatory disorders" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "H. De Boeck" 1 => "T. Scheerlinck" 2 => "J. Otten" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Acta Orthop Belg" "fecha" => "2000" "volumen" => "66" "paginaInicial" => "433" "paginaFinal" => "437" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11196366" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0140673603127729" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The expanding spectrum of systemic autoinflammatory disorders and their rheumatic manifestations" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "K.M. Hull" 1 => "N. Shoham" 2 => "J.J. Chae" 3 => "I. Aksentijevich" 4 => "D.L. Kastner" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Curr Opin Rheumatol" "fecha" => "2003" "volumen" => "15" "paginaInicial" => "61" "paginaFinal" => "69" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12496512" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "CIAS1 mutation in a patient with overlap between Muckle-Wells and chronic infantile neurological cutaneous and articular syndromes" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "B. Granel" 1 => "N. Philip" 2 => "J. Serratrice" 3 => "N. Ene" 4 => "G. Grateau" 5 => "C. Dodé" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "68883" "Revista" => array:6 [ "tituloSerie" => "Dermatology" "fecha" => "2003" "volumen" => "206" "paginaInicial" => "257" "paginaFinal" => "259" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12673085" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intrafamilial variable phenotypic expression of a CIAS1 mutation: from Muckle-Wells to chronic infantile neurological cutaneous and articular syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "V. Hentgen" 1 => "V. Despert" 2 => "A.C. Lepretre" 3 => "L. Cuisset" 4 => "J. Chevrant-Breton" 5 => "P. Jego" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Rheumatol" "fecha" => "2005" "volumen" => "32" "paginaInicial" => "747" "paginaFinal" => "751" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15801036" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "H.M. Hoffman" 1 => "J.L. Mueller" 2 => "D.H. Broide" 3 => "A.A. Wanderer" 4 => "R.D. Kolodner" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/ng756" "Revista" => array:6 [ "tituloSerie" => "Nature Genet" "fecha" => "2001" "volumen" => "29" "paginaInicial" => "301" "paginaFinal" => "305" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11687797" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neonatal onset multisystem inflammatory disorder: the emerging role of pyrin genes in autoinflammatory diseases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "C. Kilcline" 1 => "K. Shinkai" 2 => "A. Bree" 3 => "R. Modica" 4 => "E. Von Scheven" 5 => "I.J. Frieden" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/archderm.141.2.248" "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "2005" "volumen" => "141" "paginaInicial" => "248" "paginaFinal" => "253" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15724022" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neonatal-onset multisystem inflammatory disease responsive to interleukin-Ibeta Inhibition" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R. Goldbach-Mansky" 1 => "N.J. Daily" 2 => "S.W. Canna" 3 => "A. Gelabert" 4 => "J. Jones" 5 => "B.I. Rubin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "N Engl J Med" "fecha" => "2006" "volumen" => "355" "paginaInicial" => "646" "paginaFinal" => "647" ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Interleukin-1 blockade by anakinra improves clinical and symptoms in patients with neonatal onset multisystem inflammatory disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D.J. Lovell" 1 => "S.L. Bowyer" 2 => "A.M. Solinger" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "2005" "volumen" => "52" "paginaInicial" => "183" "paginaFinal" => "184" ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Anakinra in mutationnegative CINCA syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "Jl. Callejas" 1 => "J. Oliver" 2 => "J. Martín" 3 => "N. Ortego" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s10067-005-0168-z" "Revista" => array:6 [ "tituloSerie" => "Clin Rheumatol" "fecha" => "2007" "volumen" => "26" "paginaInicial" => "576" "paginaFinal" => "577" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16440135" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000009900000006/v1_201304241435/S1578219008702944/v1_201304241435/en/main.assets" "Apartado" => array:4 [ "identificador" => "6183" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Case Reports" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000009900000006/v1_201304241435/S1578219008702944/v1_201304241435/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219008702944?idApp=UINPBA000044" ]
Year/Month | Html | Total | |
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2024 November | 10 | 14 | 24 |
2024 October | 58 | 44 | 102 |
2024 September | 56 | 31 | 87 |
2024 August | 85 | 51 | 136 |
2024 July | 74 | 32 | 106 |
2024 June | 68 | 24 | 92 |
2024 May | 72 | 35 | 107 |
2024 April | 61 | 31 | 92 |
2024 March | 68 | 48 | 116 |
2024 February | 56 | 38 | 94 |
2024 January | 52 | 63 | 115 |
2023 December | 36 | 31 | 67 |
2023 November | 50 | 37 | 87 |
2023 October | 43 | 27 | 70 |
2023 September | 69 | 39 | 108 |
2023 August | 28 | 25 | 53 |
2023 July | 30 | 34 | 64 |
2023 June | 43 | 21 | 64 |
2023 May | 34 | 23 | 57 |
2023 April | 28 | 18 | 46 |
2023 March | 22 | 18 | 40 |
2023 February | 23 | 17 | 40 |
2023 January | 31 | 22 | 53 |
2022 December | 32 | 37 | 69 |
2022 November | 17 | 33 | 50 |
2022 October | 19 | 13 | 32 |
2022 September | 17 | 36 | 53 |
2022 August | 17 | 35 | 52 |
2022 July | 14 | 15 | 29 |
2022 June | 15 | 32 | 47 |
2022 May | 31 | 27 | 58 |
2022 April | 35 | 35 | 70 |
2022 March | 34 | 51 | 85 |
2022 February | 31 | 25 | 56 |
2022 January | 23 | 43 | 66 |
2021 December | 23 | 36 | 59 |
2021 November | 31 | 48 | 79 |
2021 October | 24 | 41 | 65 |
2021 September | 19 | 32 | 51 |
2021 August | 20 | 19 | 39 |
2021 July | 16 | 27 | 43 |
2021 June | 20 | 25 | 45 |
2021 May | 14 | 26 | 40 |
2021 April | 55 | 68 | 123 |
2021 March | 70 | 23 | 93 |
2021 February | 62 | 19 | 81 |
2021 January | 27 | 20 | 47 |
2020 December | 24 | 17 | 41 |
2020 November | 31 | 16 | 47 |
2020 October | 22 | 10 | 32 |
2020 September | 9 | 12 | 21 |
2020 August | 22 | 26 | 48 |
2020 July | 14 | 10 | 24 |
2020 June | 18 | 25 | 43 |
2020 May | 22 | 19 | 41 |
2020 April | 21 | 18 | 39 |
2020 March | 19 | 28 | 47 |
2020 February | 3 | 2 | 5 |
2020 January | 0 | 10 | 10 |
2019 December | 0 | 10 | 10 |
2019 November | 0 | 1 | 1 |
2019 October | 0 | 1 | 1 |
2019 September | 0 | 1 | 1 |
2019 August | 0 | 1 | 1 |
2019 July | 0 | 1 | 1 |
2019 June | 0 | 1 | 1 |
2019 May | 0 | 39 | 39 |
2019 April | 0 | 2 | 2 |
2019 March | 0 | 1 | 1 |
2019 February | 0 | 6 | 6 |
2018 December | 0 | 1 | 1 |
2018 November | 0 | 1 | 1 |
2018 October | 0 | 1 | 1 |
2018 April | 0 | 1 | 1 |
2018 March | 8 | 3 | 11 |
2018 February | 9 | 6 | 15 |
2018 January | 28 | 10 | 38 |
2017 December | 16 | 13 | 29 |
2017 November | 10 | 2 | 12 |
2017 October | 14 | 6 | 20 |
2017 September | 17 | 13 | 30 |
2017 August | 23 | 8 | 31 |
2017 July | 8 | 9 | 17 |
2017 June | 15 | 19 | 34 |
2017 May | 15 | 5 | 20 |
2017 April | 22 | 19 | 41 |
2017 March | 19 | 67 | 86 |
2017 February | 18 | 15 | 33 |
2017 January | 13 | 11 | 24 |
2016 December | 23 | 14 | 37 |
2016 November | 23 | 9 | 32 |
2016 October | 27 | 16 | 43 |
2016 September | 32 | 9 | 41 |
2016 August | 30 | 12 | 42 |
2016 July | 23 | 15 | 38 |
2016 June | 12 | 8 | 20 |
2016 May | 9 | 7 | 16 |
2016 April | 8 | 15 | 23 |
2016 March | 6 | 13 | 19 |
2016 February | 7 | 10 | 17 |
2016 January | 7 | 11 | 18 |
2015 December | 5 | 9 | 14 |
2015 November | 15 | 6 | 21 |
2015 October | 9 | 10 | 19 |
2015 September | 12 | 7 | 19 |
2015 August | 12 | 2 | 14 |
2015 July | 36 | 12 | 48 |
2015 June | 28 | 7 | 35 |
2015 May | 73 | 15 | 88 |
2015 April | 33 | 14 | 47 |
2015 March | 54 | 7 | 61 |
2015 February | 26 | 23 | 49 |
2015 January | 23 | 12 | 35 |
2014 December | 21 | 11 | 32 |
2014 November | 25 | 13 | 38 |
2014 October | 41 | 17 | 58 |
2014 September | 24 | 12 | 36 |
2014 August | 38 | 15 | 53 |
2014 July | 47 | 21 | 68 |
2014 June | 42 | 12 | 54 |
2014 May | 52 | 11 | 63 |
2014 April | 30 | 9 | 39 |
2014 March | 49 | 19 | 68 |
2014 February | 24 | 20 | 44 |
2014 January | 34 | 14 | 48 |
2013 December | 36 | 12 | 48 |
2013 November | 29 | 11 | 40 |
2013 October | 25 | 15 | 40 |
2013 September | 34 | 28 | 62 |
2013 August | 28 | 28 | 56 |
2013 July | 29 | 24 | 53 |
2013 June | 29 | 28 | 57 |
2013 May | 26 | 25 | 51 |
2013 April | 33 | 21 | 54 |
2013 March | 26 | 23 | 49 |
2013 February | 26 | 12 | 38 |
2013 January | 12 | 5 | 17 |