Case report
A Case of Cutaneous Extramedullary Hematopoiesis Associated with Idiopathic Myelofibrosis
Hematopoyesis Extramedular Cutánea en Mielofibrosis Idiopática: A Propósito de un Caso
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"apellidos" => "Alomar" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Departamento de Dermatología, Hospital Santa Creu i Sant Pau, Sant Antoni Maria Claret, 167, 08025 Barcelona, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Hematopoyesis Extramedular Cutánea en Mielofibrosis Idiopática: A Propósito de un Caso" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2007-07-06" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84176" "palabras" => array:5 [ 0 => "extramedullary hematopoiesis" 1 => "idiopathic myelofibrosis" 2 => "erythroid precursors" 3 => "myeloid precursors" 4 => "megakaryocytes" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84175" "palabras" => array:4 [ 0 => "hematopoyesis extramedular" 1 => "mielofibrosis idiopática" 2 => "precursores eritroides" 3 => "mieloides y megacariocitos" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Cutaneous extramedullary hematopoiesis is a rare manifestation of chronic myeloproliferative processes, mainly chronic idiopathic myelofibrosis. In adults, it manifests as macules, papules, nodules, and ulcers on the trunk. The lesions usually appear soon after diagnosis and the possibility of a relationship between splenectomy and the appearance of extramedullary foci of hematopoiesis is still debated. Diagnosis is based on histopathology showing an infiltrate with different combinations of myeloid and erythroid cell precursors and megakaryocytes. Symptomatic treatment is provided alongside treatment of the underlying disease. We report a new case associated with chronic idiopathic myelofibrosis in which foci of cutaneous extramedullary hematopoiesis were observed 9 years after initial diagnosis. The lesions were progressive and the patient went on to develop acute myeloid leukemia.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">La hematopoyesis extramedular cutánea es una manifestación infrecuente de los procesos mieloproliferativos crónicos, principalmente de la mielofibrosis crónica idiopática. En el adulto se manifiesta como máculas, pápulas, nódulos y úlceras en el tronco. La aparición suele darse poco después del diagnóstico y todavía es una cuestión debatida la posible relación entre la esplenectomía y la aparición de los focos de hematopoyesis extramedular. El diagnóstico se realiza mediante estudio histopatológico y la visualización de un infiltrado compuesto por diferentes combinaciones de precursores mieloides, eritroides y células megacariocíticas. El tratamiento es sintomático y el propio de la enfermedad de base. Aportamos un nuevo caso asociado a mielofibrosis crónica idiopática que a los 9 años del diagnóstico presentó focos de hematopoyesis extramedular cutánea. Dichas lesiones siguieron un curso progresivo, desarrollando posteriormente una leucemia mieloide aguda.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:17 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous extramedullary hematopoiesis in a patient with acute myelofibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "L. Puig" 1 => "M. Pilar García" 2 => "J.M. de Moragas" 3 => "X. Matias Guiu" 4 => "A. Moreno" 5 => "J. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 8 | 11 | 19 |
| 2024 October | 82 | 62 | 144 |
| 2024 September | 58 | 43 | 101 |
| 2024 August | 102 | 78 | 180 |
| 2024 July | 74 | 49 | 123 |
| 2024 June | 61 | 49 | 110 |
| 2024 May | 65 | 49 | 114 |
| 2024 April | 52 | 47 | 99 |
| 2024 March | 58 | 55 | 113 |
| 2024 February | 52 | 59 | 111 |
| 2024 January | 49 | 60 | 109 |
| 2023 December | 52 | 58 | 110 |
| 2023 November | 51 | 78 | 129 |
| 2023 October | 50 | 64 | 114 |
| 2023 September | 34 | 58 | 92 |
| 2023 August | 31 | 21 | 52 |
| 2023 July | 31 | 52 | 83 |
| 2023 June | 48 | 46 | 94 |
| 2023 May | 35 | 33 | 68 |
| 2023 April | 26 | 25 | 51 |
| 2023 March | 24 | 40 | 64 |
| 2023 February | 33 | 31 | 64 |
| 2023 January | 28 | 43 | 71 |
| 2022 December | 32 | 64 | 96 |
| 2022 November | 16 | 29 | 45 |
| 2022 October | 21 | 18 | 39 |
| 2022 September | 18 | 33 | 51 |
| 2022 August | 29 | 34 | 63 |
| 2022 July | 24 | 37 | 61 |
| 2022 June | 22 | 48 | 70 |
| 2022 May | 48 | 42 | 90 |
| 2022 April | 39 | 65 | 104 |
| 2022 March | 43 | 67 | 110 |
| 2022 February | 35 | 24 | 59 |
| 2022 January | 18 | 43 | 61 |
| 2021 December | 34 | 38 | 72 |
| 2021 November | 33 | 51 | 84 |
| 2021 October | 34 | 41 | 75 |
| 2021 September | 29 | 37 | 66 |
| 2021 August | 14 | 36 | 50 |
| 2021 July | 27 | 29 | 56 |
| 2021 June | 16 | 25 | 41 |
| 2021 May | 17 | 35 | 52 |
| 2021 April | 34 | 52 | 86 |
| 2021 March | 62 | 23 | 85 |
| 2021 February | 53 | 30 | 83 |
| 2021 January | 37 | 15 | 52 |
| 2020 December | 15 | 16 | 31 |
| 2020 November | 14 | 15 | 29 |
| 2020 October | 24 | 9 | 33 |
| 2020 September | 33 | 16 | 49 |
| 2020 August | 26 | 25 | 51 |
| 2020 July | 27 | 5 | 32 |
| 2020 June | 20 | 21 | 41 |
| 2020 May | 33 | 18 | 51 |
| 2020 April | 21 | 25 | 46 |
| 2020 March | 30 | 17 | 47 |
| 2020 February | 1 | 1 | 2 |
| 2020 January | 0 | 7 | 7 |
| 2019 December | 0 | 13 | 13 |
| 2019 November | 0 | 5 | 5 |
| 2019 October | 0 | 4 | 4 |
| 2019 September | 0 | 11 | 11 |
| 2019 August | 0 | 10 | 10 |
| 2019 July | 0 | 16 | 16 |
| 2019 June | 0 | 21 | 21 |
| 2019 May | 0 | 118 | 118 |
| 2019 April | 0 | 51 | 51 |
| 2019 March | 0 | 12 | 12 |
| 2019 February | 0 | 11 | 11 |
| 2019 January | 0 | 10 | 10 |
| 2018 September | 0 | 6 | 6 |
| 2018 August | 0 | 25 | 25 |
| 2018 July | 0 | 7 | 7 |
| 2018 June | 0 | 4 | 4 |
| 2018 May | 0 | 5 | 5 |
| 2018 April | 0 | 15 | 15 |
| 2018 March | 0 | 3 | 3 |
| 2018 February | 15 | 13 | 28 |
| 2018 January | 26 | 20 | 46 |
| 2017 December | 22 | 9 | 31 |
| 2017 November | 21 | 9 | 30 |
| 2017 October | 22 | 13 | 35 |
| 2017 September | 38 | 22 | 60 |
| 2017 August | 43 | 16 | 59 |
| 2017 July | 19 | 36 | 55 |
| 2017 June | 36 | 45 | 81 |
| 2017 May | 38 | 35 | 73 |
| 2017 April | 32 | 28 | 60 |
| 2017 March | 42 | 35 | 77 |
| 2017 February | 18 | 45 | 63 |
| 2017 January | 21 | 25 | 46 |
| 2016 December | 33 | 24 | 57 |
| 2016 November | 36 | 34 | 70 |
| 2016 October | 36 | 34 | 70 |
| 2016 September | 43 | 37 | 80 |
| 2016 August | 33 | 36 | 69 |
| 2016 July | 37 | 17 | 54 |
| 2016 June | 15 | 14 | 29 |
| 2016 May | 5 | 13 | 18 |
| 2016 April | 7 | 32 | 39 |
| 2016 March | 5 | 25 | 30 |
| 2016 February | 5 | 24 | 29 |
| 2016 January | 8 | 36 | 44 |
| 2015 December | 9 | 1 | 10 |
| 2015 November | 9 | 20 | 29 |
| 2015 October | 9 | 28 | 37 |
| 2015 September | 12 | 19 | 31 |
| 2015 August | 16 | 12 | 28 |
| 2015 July | 27 | 23 | 50 |
| 2015 June | 34 | 23 | 57 |
| 2015 May | 63 | 40 | 103 |
| 2015 April | 45 | 28 | 73 |
| 2015 March | 37 | 31 | 68 |
| 2015 February | 28 | 26 | 54 |
| 2015 January | 24 | 31 | 55 |
| 2014 December | 43 | 20 | 63 |
| 2014 November | 28 | 15 | 43 |
| 2014 October | 36 | 25 | 61 |
| 2014 September | 33 | 25 | 58 |
| 2014 August | 47 | 26 | 73 |
| 2014 July | 37 | 30 | 67 |
| 2014 June | 47 | 16 | 63 |
| 2014 May | 38 | 14 | 52 |
| 2014 April | 37 | 8 | 45 |
| 2014 March | 46 | 32 | 78 |
| 2014 February | 38 | 27 | 65 |
| 2014 January | 28 | 38 | 66 |
| 2013 December | 41 | 20 | 61 |
| 2013 November | 29 | 29 | 58 |
| 2013 October | 26 | 38 | 64 |
| 2013 September | 29 | 45 | 74 |
| 2013 August | 30 | 46 | 76 |
| 2013 July | 40 | 86 | 126 |
| 2013 June | 30 | 43 | 73 |
| 2013 May | 30 | 55 | 85 |
| 2013 April | 39 | 59 | 98 |
| 2013 March | 28 | 40 | 68 |
| 2013 February | 32 | 23 | 55 |
| 2013 January | 15 | 8 | 23 |
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