Original articles
Epidermodysplasia Verruciformis-Like Cells as Histologic Markers of Immunosuppression: Review of 229 Squamous Cell Carcinomas*
Las Células Tipo Epidermodisplasia Verruciforme Como Marcador Histológico de Inmunodepresión: Revisión de 229 Carcinomas Espinocelulares
R. Corbalán-Véleza,
, J.A. Ruiz-Maciáb, C. Brufauc, J.M. López-Lozanod, E. Martínez-Barbae, J. Martínez-Escribanoa, F.J. Carapetof
Corresponding author
raulcorb@gmail.com
Correspondence: Servicio de Dermatología, Hospital Universitario Virgen de la Arrixaca, Ctra. Murcia-Cartagena, s/n, 30120 El Palmar, Murcia, Spain.
Correspondence: Servicio de Dermatología, Hospital Universitario Virgen de la Arrixaca, Ctra. Murcia-Cartagena, s/n, 30120 El Palmar, Murcia, Spain.
a Servicio de Dermatología, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain
b Servicio de Anatomía Patológica, Hospital Vega Baja, Orihuela, Alicante, Spain
c Servicio de Dermatología, Hospital General Reina Sofía, Murcia, Spain
d Servicio de Medicina Preventiva, Hospital Vega Baja, Orihuela, Alicante, Spain
e Servicio de Anatomía Patológica, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain
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Murcia-Cartagena, s/n, 30120 El Palmar, Murcia, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Las Células Tipo Epidermodisplasia Verruciforme Como Marcador Histológico de Inmunodepresión: Revisión de 229 Carcinomas Espinocelulares" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2007-09-11" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84166" "palabras" => array:4 [ 0 => "epidermodysplasia verruciformis" 1 => "immunosuppression" 2 => "papillomavirus" 3 => "solar elastosis" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84165" "palabras" => array:4 [ 0 => "epidermodisplasia verruciforme" 1 => "inmunodepresión" 2 => "papilomavirus" 3 => "elastosis solar" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p class="elsevierStyleSimplePara elsevierViewall">Epidermodysplasia verruciformis (EV) is associated with greater susceptibility to infection by certain oncogenic subtypes of human papillomavirus (HPV). Among other histologic findings, large, clear, oval or rounded cells (EV cells) are observed in the granular layer in EV, and some authors consider these cells to be markers of immunosuppression.</p> <span class="elsevierStyleSectionTitle">Material and Methods</span><p class="elsevierStyleSimplePara elsevierViewall">We analyzed 229 squamous cell carcinomas (SCC) to determine whether EV cells were present and to assess whether their presence was associated either with localized or cutaneous immunosuppression (tumors with signs of severe chronic actinic damage or severe stasis dermatitis) or with systemic immunosuppression (immunocompromised or elderly patients).</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">We observed EV cells in 33 SCC. No statistically significant relationship was observed between the presence of EV cells and immunosuppression. We performed polymerase chain reaction in 8 lesions, but the results were not informative as the DNA was denatured.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">We found no relationship between the presence of EV cells and localized or systemic immunosuppression, possibly because the sample was inadequate (almost all SCC studied were associated with signs of immunosuppression, irrespective of the presence or absence of EV cells). Further studies will be required to compare lesions associated with immunosuppression with those in which immunosuppression is absent. The presence of EV cells may be the result of cytopathic effects of certain HPV subtypes, such as HPV 5 or 8, but this will need to be demonstrated using techniques such as polymerase chain reaction.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p class="elsevierStyleSimplePara elsevierViewall">La epidermodisplasia verruciforme (EV) es una enfermedad en la que existe una mayor susceptibilidad genética a la infección por determinados subtipos oncogénicos del virus del papiloma humano (VPH). Entre otros hallazgos histológicos, en la EV suelen observarse unas células claras, grandes, ovaladas o redondeadas (células EV) en la capa granulosa, que según algunos autores se podrían considerar como un marcador histológico de inmunodepresión.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Hemos estudiado 229 carcinomas espinocelulares (CE) para valorar si presentaban células EV y si se relacionaban con inmunodepresión, tanto localizada o cutánea (tumores con signos de intenso daño solar crónico o con una dermatitis de estasis intensa), como sistémica (pacientes inmunodeprimidos o ancianos).</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Observamos células EV en 33 carcinomas. No hemos encontrado relación significativa entre la existencia de células EV e inmunodepresión. Realizamos reacción en cadena de la polimerasa (PCR) en 8 lesiones, pero los resultados no fueron valorables porque el ADN estaba desnaturalizado.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">No hemos demostrado relación entre las células EV e inmunodepresión, localizada o sistémica, posiblemente porque la muestra no era adecuada (se podría considerar que prácticamente todos los CE estudiados se asociaban a signos de inmunodepresión, tanto aquellos que presentaban células EV como los que no). Serían necesarios más estudios que comparasen lesiones asociadas a inmunodepresión con otras que no. Es posible que estas células EV sean el resultado de los efectos citopáticos de determinados subtipos de VPH, como el VPH-5 o el VPH-8, aunque sería necesario demostrar esta hipótesis mediante técnicas de PCR o similar.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "nota" => "<p class="elsevierStyleNotepara">2006 August C. Stiefel Award.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:27 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidermodysplasia verruciformis as a model of Human Papillomavirus-inducel genetic cancer of the skin" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S. Majewski" 1 => "S. Jablonska" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "1995" "volumen" => "131" "paginaInicial" => "1312" "paginaFinal" => "1318" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7503577" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidermodisplasia verruciforme" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "V.P. Sánchez-García" 1 => "A. Sanz" 2 => "C. Eloy" 3 => "A. Vera" 4 => "T. Martín" 5 => "F. Sánchez-Fajardo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2005" "volumen" => "96" "paginaInicial" => "531" "paginaFinal" => "533" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16476290" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical aspects of epidermodysplasia verruciformis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "W.R. de Oliveira" 1 => "C. Festa Neto" 2 => "P.L. Rady" 3 => "S.K. Tyring" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Eur Acad Dermatol Venereol" "fecha" => "2003" "volumen" => "17" "paginaInicial" => "394" "paginaFinal" => "398" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12834447" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Partial defects of cell-mediated immunity in patients with epidermodysplasia verruciformis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "S. Majewski" 1 => "E. Skipinska-Rozewska" 2 => "S. Jablonska" 3 => "M. Wasik" 4 => "J. Misiewicz" 5 => "G. Orth" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "1986" "volumen" => "15" "paginaInicial" => "966" "paginaFinal" => "973" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3491095" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Natural cell-mediated cytotoxicity against various target cells in patients with epidermodysplasia verruciformis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Majewski" 1 => "J. Malejczyk" 2 => "S. Jablonska" 3 => "J. Misiewicz" 4 => "L. Rudnicka" 5 => "S. Obalek" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "1990" "volumen" => "22" "paginaInicial" => "423" "paginaFinal" => "427" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2155952" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The histologic spectrum of Epidermodysplasia Verruciformis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G.J. Nuovo" 1 => "M. Ishag" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Surg Pathol" "fecha" => "2000" "volumen" => "24" "paginaInicial" => "1400" "paginaFinal" => "1406" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11023102" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Viral diseases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D. Weedon" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Skin Pathology" "paginaInicial" => "583" "paginaFinal" => "603" "serieFecha" => "1998" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Skin cancer in organ transplant recipients: Epidemiology, pathogenesis, and management" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D. Berg" 1 => "C.C. Otley" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2002" "volumen" => "47" "paginaInicial" => "1" "paginaFinal" => "17" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12077575" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Shortage of circulating naive CD8 ??T cells provides new insights on immunodeficiency in aging" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F.F. Fagnoni" 1 => "R. Vescovini" 2 => "G. Passeri" 3 => "G. Bologna" 4 => "M. Pedrazzoni" 5 => "G. Lavagetto" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Blood" "fecha" => "2000" "volumen" => "95" "paginaInicial" => "2860" "paginaFinal" => "2868" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10779432" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidemiología e inmunopatogenia del cáncer cutáneo no melanoma. El papel iniciador y promotor del VPH" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "V.G. Villarrubia" 1 => "L.A. Costa" 2 => "M. Pérez" 3 => "S. Vidal" 4 => "P. Jaen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Piel" "fecha" => "2001" "volumen" => "16" "paginaInicial" => "428" "paginaFinal" => "438" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mechanism involved in ultraviolet light-induced immunosuppression" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "F. Aubin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur J Dermatol" "fecha" => "2003" "volumen" => "13" "paginaInicial" => "515" "paginaFinal" => "523" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14721768" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Efectos de la radiación ultravioleta sobre el sistema inmunitario. Implicaciones terapéuticas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.M. Carrascosa" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Piel" "fecha" => "2004" "volumen" => "19" "paginaInicial" => "303" "paginaFinal" => "312" ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidermodysplasia verruciformisassociated papillomavirus infection complicating human immunodeficiency virus disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "T.G. Berger" 1 => "W.S. Sawchuk" 2 => "C. Leonardi" 3 => "A. Langenberg" 4 => "J. Tappero" 5 => "P.E. Leboit" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "1991" "volumen" => "124" "paginaInicial" => "79" "paginaFinal" => "83" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1847068" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidermodysplasia verruciformis in a patient with Hodgkin's disease: characterization of a new papilloma virus type and interferon treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "G. Gross" 1 => "K. Ellinger" 2 => "A. Roussaki" 3 => "P.G. Fuchs" 4 => "H.H. Peter" 5 => "H. Pfister" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Invest Dermatol" "fecha" => "1989" "volumen" => "91" "paginaInicial" => "43" "paginaFinal" => "48" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2838553" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidermodysplasia verruciformis associated with severe immunodeficiency, lymphoma, and disseminated molluscum contagiosum" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "L.D. Slawsky" 1 => "R.T. Gilson" 2 => "A.J. Hockley" 3 => "L.F. Libow" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "1992" "volumen" => "27" "paginaInicial" => "448" "paginaFinal" => "450" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1401282" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Swollen keratinocytes: a histologic marker of unusual human papillomavirus-type infection and immunosuppression" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "N.S. Penneys" 1 => "A. Friend" 2 => "W.Y. Zhu" 3 => "C. Leonardi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Cutan Pathol" "fecha" => "1992" "volumen" => "12" "paginaInicial" => "217" "paginaFinal" => "220" "itemHostRev" => array:3 [ "pii" => "S001651071002331X" "estado" => "S300" "issn" => "00165107" ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Métodos moleculares de detección de mutaciones en dermatología" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "P. Unamuno" 1 => "R. Gónzalez Sarmiento" 2 => "S. Mallo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Piel" "fecha" => "2004" "volumen" => "19" "paginaInicial" => "107" "paginaFinal" => "114" ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bioestadística. Métodos estadísticos para investigadores" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.M. Doménech Massons" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:3 [ "fecha" => "1982" "editorial" => "Herder" "editorialLocalizacion" => "Barcelona" ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "¿Qué es una odds ratio?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M. Martínez González" 1 => "J. Irala Estévez" 2 => "F. Guillén Grima" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Clin (Barc)" "fecha" => "1999" "volumen" => "112" "paginaInicial" => "416" "paginaFinal" => "422" ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Carcinomas espinocelulares" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "S. Yáñez-Díaz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Tumores Cutáneos" "paginaInicial" => "97" "paginaFinal" => "116" "serieFecha" => "1999" ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Carcinoma espinocelular cutáneo y papilomavirus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R. Corbalán-Vélez" 1 => "J.A. Ruiz-Maciá" 2 => "C. Brufau" 3 => "F.J. Carapeto" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2007" "volumen" => "98" "paginaInicial" => "583" "paginaFinal" => "593" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17961447" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Detection of epidermodysplasia verruciformis-like human papillomavirus types in malignant and premalignant skin lesions of renal transplant recipients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L.M. Tieben" 1 => "R.J. Berkhout" 2 => "H.L. Smits" 3 => "J.N. Bouves Bavinck" 4 => "B.J. Vermeer" 5 => "J.A. Bruijn" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "1994" "volumen" => "131" "paginaInicial" => "226" "paginaFinal" => "230" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7917987" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Detection of human papillomavirus type 5 DNA in skin cancers of an immunosupressed renal allograft recipient" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M.A. Lutzner" 1 => "G. Orth" 2 => "V. Dutronquay" 3 => "M.F. Ducasse" 4 => "H. Kreis" 5 => "J. Crosnier" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1983" "volumen" => "2" "paginaInicial" => "422" "paginaFinal" => "424" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6147500" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Human papillomavirus type 5 is commonly present in immunosuppressed and immunocompetent individuals" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "I.L. Boxman" 1 => "L.H. Mulder" 2 => "A. Russell" 3 => "J.N. Bouwes Bavinck" 4 => "A. Green" 5 => "J. Ter Schegget" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "1999" "volumen" => "141" "paginaInicial" => "246" "paginaFinal" => "249" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10468795" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Use of polymerase chain reaction amplification for the detection of genital human papillomavirus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.M. Manos" 1 => "Y. Ting" 2 => "D.K. Wright" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Cancer Cel" "fecha" => "1989" "volumen" => "7" "paginaInicial" => "209" "paginaFinal" => "214" ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Detección y tipado de papilomavirus humano por amplificación genómica en biopsias, frotis y orina" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Martínez" 1 => "R. Nás" 2 => "C. LaCruz" 3 => "T. Hellín" 4 => "J.C. Tercero" 5 => "E. Valverde" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Acta Ginecológica" "fecha" => "1995" "volumen" => "52" "paginaInicial" => "51" "paginaFinal" => "56" ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparison of polymerase chain reaction and catalyzed signal amplification in situ hybridization methods for human papillomavirus detection in paraffin-embedded cervical preneoplastic and neoplastic lesions" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M.M. Dabic" 1 => "L. Hlupic" 2 => "D. Babic" 3 => "S. Jukic" 4 => "S. Seiwerth" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.arcmed.2004.07.004" "Revista" => array:6 [ "tituloSerie" => "Arch Med Res" "fecha" => "2004" "volumen" => "35" "paginaInicial" => "511" "paginaFinal" => "516" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15631876" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000009900000004/v1_201304241431/S1578219008702506/v1_201304241431/en/main.assets" "Apartado" => array:4 [ "identificador" => "6155" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original Articles" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000009900000004/v1_201304241431/S1578219008702506/v1_201304241431/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219008702506?idApp=UINPBA000044" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 1 | 10 | 11 |
| 2024 October | 64 | 47 | 111 |
| 2024 September | 71 | 31 | 102 |
| 2024 August | 98 | 62 | 160 |
| 2024 July | 72 | 46 | 118 |
| 2024 June | 78 | 41 | 119 |
| 2024 May | 49 | 33 | 82 |
| 2024 April | 70 | 24 | 94 |
| 2024 March | 65 | 53 | 118 |
| 2024 February | 43 | 38 | 81 |
| 2024 January | 56 | 36 | 92 |
| 2023 December | 53 | 30 | 83 |
| 2023 November | 46 | 23 | 69 |
| 2023 October | 35 | 27 | 62 |
| 2023 September | 38 | 27 | 65 |
| 2023 August | 18 | 19 | 37 |
| 2023 July | 25 | 47 | 72 |
| 2023 June | 30 | 17 | 47 |
| 2023 May | 33 | 23 | 56 |
| 2023 April | 25 | 19 | 44 |
| 2023 March | 24 | 23 | 47 |
| 2023 February | 27 | 21 | 48 |
| 2023 January | 25 | 25 | 50 |
| 2022 December | 28 | 35 | 63 |
| 2022 November | 11 | 60 | 71 |
| 2022 October | 15 | 16 | 31 |
| 2022 September | 20 | 36 | 56 |
| 2022 August | 11 | 30 | 41 |
| 2022 July | 18 | 30 | 48 |
| 2022 June | 22 | 36 | 58 |
| 2022 May | 23 | 38 | 61 |
| 2022 April | 22 | 47 | 69 |
| 2022 March | 23 | 44 | 67 |
| 2022 February | 21 | 27 | 48 |
| 2022 January | 23 | 35 | 58 |
| 2021 December | 19 | 39 | 58 |
| 2021 November | 24 | 45 | 69 |
| 2021 October | 23 | 42 | 65 |
| 2021 September | 17 | 30 | 47 |
| 2021 August | 19 | 34 | 53 |
| 2021 July | 26 | 36 | 62 |
| 2021 June | 19 | 38 | 57 |
| 2021 May | 31 | 45 | 76 |
| 2021 April | 38 | 63 | 101 |
| 2021 March | 60 | 14 | 74 |
| 2021 February | 65 | 22 | 87 |
| 2021 January | 31 | 13 | 44 |
| 2020 December | 24 | 18 | 42 |
| 2020 November | 33 | 18 | 51 |
| 2020 October | 26 | 10 | 36 |
| 2020 September | 35 | 11 | 46 |
| 2020 August | 30 | 16 | 46 |
| 2020 July | 19 | 13 | 32 |
| 2020 June | 23 | 25 | 48 |
| 2020 May | 29 | 18 | 47 |
| 2020 April | 24 | 16 | 40 |
| 2020 March | 17 | 27 | 44 |
| 2020 February | 3 | 1 | 4 |
| 2020 January | 0 | 8 | 8 |
| 2019 December | 0 | 12 | 12 |
| 2019 November | 0 | 4 | 4 |
| 2019 October | 0 | 4 | 4 |
| 2019 September | 0 | 4 | 4 |
| 2019 August | 0 | 1 | 1 |
| 2019 July | 0 | 9 | 9 |
| 2019 June | 0 | 13 | 13 |
| 2019 May | 1 | 67 | 68 |
| 2019 April | 2 | 13 | 15 |
| 2019 March | 0 | 4 | 4 |
| 2019 February | 0 | 6 | 6 |
| 2019 January | 0 | 1 | 1 |
| 2018 August | 0 | 1 | 1 |
| 2018 July | 0 | 1 | 1 |
| 2018 June | 0 | 2 | 2 |
| 2018 May | 0 | 14 | 14 |
| 2018 April | 0 | 3 | 3 |
| 2018 March | 1 | 1 | 2 |
| 2018 February | 7 | 9 | 16 |
| 2018 January | 18 | 7 | 25 |
| 2017 December | 16 | 11 | 27 |
| 2017 November | 9 | 6 | 15 |
| 2017 October | 17 | 10 | 27 |
| 2017 September | 10 | 11 | 21 |
| 2017 August | 14 | 6 | 20 |
| 2017 July | 10 | 6 | 16 |
| 2017 June | 16 | 22 | 38 |
| 2017 May | 9 | 26 | 35 |
| 2017 April | 19 | 7 | 26 |
| 2017 March | 18 | 13 | 31 |
| 2017 February | 12 | 12 | 24 |
| 2017 January | 13 | 8 | 21 |
| 2016 December | 31 | 7 | 38 |
| 2016 November | 25 | 4 | 29 |
| 2016 October | 30 | 10 | 40 |
| 2016 September | 31 | 7 | 38 |
| 2016 August | 26 | 5 | 31 |
| 2016 July | 27 | 5 | 32 |
| 2016 June | 6 | 5 | 11 |
| 2016 May | 8 | 4 | 12 |
| 2016 April | 8 | 7 | 15 |
| 2016 March | 2 | 17 | 19 |
| 2016 February | 2 | 20 | 22 |
| 2016 January | 9 | 15 | 24 |
| 2015 December | 10 | 9 | 19 |
| 2015 November | 12 | 6 | 18 |
| 2015 October | 11 | 11 | 22 |
| 2015 September | 10 | 11 | 21 |
| 2015 August | 12 | 2 | 14 |
| 2015 July | 26 | 9 | 35 |
| 2015 June | 27 | 8 | 35 |
| 2015 May | 78 | 6 | 84 |
| 2015 April | 26 | 8 | 34 |
| 2015 March | 32 | 1 | 33 |
| 2015 February | 26 | 6 | 32 |
| 2015 January | 27 | 10 | 37 |
| 2014 December | 19 | 2 | 21 |
| 2014 November | 22 | 8 | 30 |
| 2014 October | 37 | 7 | 44 |
| 2014 September | 29 | 9 | 38 |
| 2014 August | 45 | 19 | 64 |
| 2014 July | 41 | 21 | 62 |
| 2014 June | 35 | 7 | 42 |
| 2014 May | 53 | 13 | 66 |
| 2014 April | 33 | 10 | 43 |
| 2014 March | 48 | 19 | 67 |
| 2014 February | 33 | 13 | 46 |
| 2014 January | 27 | 14 | 41 |
| 2013 December | 36 | 9 | 45 |
| 2013 November | 25 | 17 | 42 |
| 2013 October | 27 | 18 | 45 |
| 2013 September | 22 | 15 | 37 |
| 2013 August | 27 | 38 | 65 |
| 2013 July | 39 | 31 | 70 |
| 2013 June | 28 | 26 | 54 |
| 2013 May | 21 | 25 | 46 |
| 2013 April | 28 | 45 | 73 |
| 2013 March | 30 | 32 | 62 |
| 2013 February | 26 | 9 | 35 |
| 2013 January | 14 | 4 | 18 |
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