Original articles
Analysis of Cytogenetic Abnormalities in Squamous Cell Carcinoma by Array Comparative Genomic Hybridization
Estudio de Las Lesiones Citogenéticas en el Carcinoma Escamoso Cutá-Neo Mediante la Técnica de Arrays de Hibridación Genómica Comparada
Read
6108
Timeswas read the article
2630
Total PDF
3478
Total HTML
Share statistics
array:23 [ "pii" => "S1578219008702324" "issn" => "15782190" "doi" => "10.1016/S1578-2190(08)70232-4" "estado" => "S300" "fechaPublicacion" => "2008-04-01" "aid" => "70232" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "copyrightAnyo" => "2008" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2008;99:199-206" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2423 "formatos" => array:3 [ "EPUB" => 35 "HTML" => 1531 "PDF" => 857 ] ] "itemSiguiente" => array:18 [ "pii" => "S1578219008702336" "issn" => "15782190" "doi" => "10.1016/S1578-2190(08)70233-6" "estado" => "S300" "fechaPublicacion" => "2008-04-01" "aid" => "70233" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2008;99:207-12" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2579 "formatos" => array:3 [ "EPUB" => 38 "HTML" => 1622 "PDF" => 919 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original articles</span>" "titulo" => "Diagnostic Agreement Between Primary Care Physicians and Dermatologists in the Health Area of a Referral Hospital" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "207" "paginaFinal" => "212" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Estudio de Concordancia Diagnóstica en Dermatología Entre Atención Primaria y Especializada en el Área de Salud de un Hospital de Referencia" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "N. Porta, J. San Juan, M.P. Grasa, E. Simal, M. Ara, I. Querol" "autores" => array:6 [ 0 => array:2 [ "nombre" => "N." "apellidos" => "Porta" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "San Juan" ] 2 => array:2 [ "nombre" => "M.P." "apellidos" => "Grasa" ] 3 => array:2 [ "nombre" => "E." "apellidos" => "Simal" ] 4 => array:2 [ "nombre" => "M." "apellidos" => "Ara" ] 5 => array:2 [ "nombre" => "I." "apellidos" => "Querol" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219008702336?idApp=UINPBA000044" "url" => "/15782190/0000009900000003/v1_201304241428/S1578219008702336/v1_201304241428/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1578219008702312" "issn" => "15782190" "doi" => "10.1016/S1578-2190(08)70231-2" "estado" => "S300" "fechaPublicacion" => "2008-04-01" "aid" => "70231" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2008;99:190-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 5492 "formatos" => array:3 [ "EPUB" => 33 "HTML" => 2398 "PDF" => 3061 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Practical dermatology</span>" "titulo" => "Recurrent Vulvovaginitis: Diagnostic Assessment and Therapeutic Management" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "190" "paginaFinal" => "198" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Vulvovaginitis de Repetición. Valoración Diagnóstica y Manejo Terapéutico" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A. Ramírez-Santos, M. Pereiro, J. Toribio" "autores" => array:3 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Ramírez-Santos" ] 1 => array:3 [ "nombre" => "M." "apellidos" => "Pereiro" "sufijo" => "Jr" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "Toribio" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219008702312?idApp=UINPBA000044" "url" => "/15782190/0000009900000003/v1_201304241428/S1578219008702312/v1_201304241428/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original articles</span>" "titulo" => "Analysis of Cytogenetic Abnormalities in Squamous Cell Carcinoma by Array Comparative Genomic Hybridization" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "199" "paginaFinal" => "206" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "R. Salgado, A. Toll, B. Espinet, E. González-Roca, C.L. Barranco, S. Serrano, F. Solé, R.M. Pujol" "autores" => array:8 [ 0 => array:3 [ "nombre" => "R." "apellidos" => "Salgado" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 1 => array:4 [ "nombre" => "A." "apellidos" => "Toll" "email" => array:1 [ 0 => "93828@imas.imim.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 2 => array:3 [ "nombre" => "B." "apellidos" => "Espinet" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 3 => array:3 [ "nombre" => "E." "apellidos" => "González-Roca" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] ] 4 => array:3 [ "nombre" => "C.L." "apellidos" => "Barranco" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 5 => array:3 [ "nombre" => "S." "apellidos" => "Serrano" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 6 => array:3 [ "nombre" => "F." "apellidos" => "Solé" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 7 => array:3 [ "nombre" => "R.M." "apellidos" => "Pujol" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Laboratorio de Citogenética y Biología Molecular, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital del Mar, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 2 => array:3 [ "entidad" => "Laboratorio de Microarrays, Departamento de Bioinformática i Genòmica, Centro de Regulación Genómica (CRG), Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Servicio de Dermatología, Hospital del Mar, Passeig Marítim, 25-29, 08003 Barcelona, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Estudio de Las Lesiones Citogenéticas en el Carcinoma Escamoso Cutá-Neo Mediante la Técnica de <span class="elsevierStyleItalic">Arrays</span> de Hibridación Genómica Comparada" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2007-09-13" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84151" "palabras" => array:4 [ 0 => "array" 1 => "comparative genomic hybridization" 2 => "cytogenetics" 3 => "cutaneous squamous cell carcinoma" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84152" "palabras" => array:4 [ 0 => "<span class="elsevierStyleItalic">array</span>" 1 => "hibridación genómica comparada" 2 => "citogenética" 3 => "carcinoma escamoso cutáneo" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p class="elsevierStyleSimplePara elsevierViewall">Few conventional cytogenetic studies of squamous cell carcinoma (SCC) have been performed to date. The introduction of cytogenetic techniques such as comparative genomic hybridization (CGH) has resolved some of the problems associated with conventional cytogenetics. The aim of this study was to analyze the presence of genetic abnormalities in a series of patients with SCC using the technique of array CGH.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">The study included 8 patients (7 men and 1 woman; mean age, 75 years) diagnosed with primary SCC. DNA was extracted from frozen tissue and analyzed by array CGH.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">All cases had genetic alterations, with gains more frequent than losses. The chromosomal regions with gains, in descending order of frequency, were as follows: 5p15.2, 9q31.3-q33.2, 13q, 18q22, 1p21-p22, 1q24-q25, 3p13, 4q33-q34 (<span class="elsevierStyleItalic">HMGB2</span>, <span class="elsevierStyleItalic">SAP30</span>), 20p12.2 (<span class="elsevierStyleItalic">JAG1</span>), 21q21.1, and Xq21.33. The region 9p13.1-p13.3 was the only one to display recurrent loss. No correlation was observed between the presence of gains or losses and the clinical and pathologic characteristics of the tumors.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">This is the first study to use the technique of array CGH to analyze genetic alterations in SCC. The finding of certain previously described aberrations (gain of 5p) suggests the existence of recurrent abnormalities. Likewise, the observation of alterations in small regions of chromosome 1 highlights the sensitivity of the technique to detect small changes. Application of the technique to a larger series of cases will provide greater insight into the genetic abnormalities implicated in the process of tumorigenesis in SCC.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p class="elsevierStyleSimplePara elsevierViewall">Los estudios de citogenética convencional realizados en el carcinoma escamoso cutáneo (CEC) son escasos. La introducción de las técnicas de citogenética, como la de hibridación genómica comparada (HGC), solventan algunos de los inconvenientes planteados por las técnicas de citogenética convencional. El objetivo de este estudio es analizar la presencia de alteraciones genéticas mediante la técnica de <span class="elsevierStyleItalic">array</span>-HGC en una serie de CEC.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Se estudiaron un total de 8 pacientes (7 varones/una mujer; edad media: 75 años) diagnosticados de CEC primario. Se realizó extracción de ADN a partir de material congelado y se realizó la técnica de <span class="elsevierStyleItalic">array</span>-HGC.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Todos los casos mostraron alteraciones genéticas, siendo más frecuentes las ganancias que las pérdidas. Las regiones cromosómicas en las que se observaron ganancias, en orden decreciente, fueron 5p15.2, 9q31.3-q33.2, 13q, 18q22, 1p21-p22, 1q24-q25, 3p13, 4q33-q34 (HMGB2, SAP30), 20p12.2 (JAG1), 21q21.1, Xq21.33. La región 9p13.1-p13.3 fue la única que mostró una pérdida recurrente. No se detectó una correlación entre la presencia de ganancias o pérdidas y las características clínico-patológicas de los tumores.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Este estudio es el primero descrito en el que se utiliza la técnica de <span class="elsevierStyleItalic">array</span>-HGC con el fin de analizar las alteraciones genéticas del CEC. El hallazgo de algunas aberraciones ya descritas (ganancia de 5p) muestra la posibilidad de que existan lesiones recurrentes. Asimismo, la observación de pequeñas regiones alteradas (cromosoma 1) demuestra la sensibilidad de esta técnica en la detección de alteraciones de pequeño tamaño. Su aplicación en una serie amplia de casos podrá proporcionar un mayor conocimiento de las alteraciones genéticas implicadas en el proceso de tumorogénesis del CEC.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">This study was funded by a grant from the Health Research Fund (Fondo de Investigación Sanitaria) of the Spanish Ministry of Health (grant PI041728).</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:25 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "DNA content and proliferative index in cutaneous squamous cell carcinoma and keratoacanthoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M.B. Randall" 1 => "K.R. Geisinger" 2 => "T.E. Kute" 3 => "D.H. Buss" 4 => "R.W. Prichard" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Clin Pathol" "fecha" => "1990" "volumen" => "93" "paginaInicial" => "259" "paginaFinal" => "262" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2301286" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sunlight and skin cancer: another link revealed" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "K.H. Kraemer" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Proc Natl Acad Sci" "fecha" => "1997" "volumen" => "94" "paginaInicial" => "11" "paginaFinal" => "14" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8990152" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genetics instabilities in human cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C. Lengauer" 1 => "K.W. Kinzler" 2 => "B. Vogelstein" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/25292" "Revista" => array:6 [ "tituloSerie" => "Nature" "fecha" => "1998" "volumen" => "396" "paginaInicial" => "643" "paginaFinal" => "649" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9872311" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ultraviolet radiation and skin carcinogenesis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A.G. Quinn" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Hosp Med" "fecha" => "1997" "volumen" => "58" "paginaInicial" => "261" "paginaFinal" => "264" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9488800" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Low doses of UVB or UVA induce chromosomal aberrations in cultured human skin cells" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Emri" 1 => "E. Wenczl" 2 => "P. Van Erp" 3 => "J. Jans" 4 => "L. Roza" 5 => "I. Horkay" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1046/j.1523-1747.2000.00057.x" "Revista" => array:6 [ "tituloSerie" => "J Invest Dermatol" "fecha" => "2000" "volumen" => "115" "paginaInicial" => "435" "paginaFinal" => "440" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10951280" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Basal cell carcinomas and squamous cell carcinomas of human skin show distinct patterns of chromosome loss" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A.G. Quinn" 1 => "S. Sikkink" 2 => "J.L. Rees" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Res" "fecha" => "1994" "volumen" => "54" "paginaInicial" => "4756" "paginaFinal" => "4759" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8062275" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Loss of heterozygosity in human skin" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R. Happle" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "1999" "volumen" => "41" "paginaInicial" => "143" "paginaFinal" => "164" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10426882" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Molecular cytogenetic aspects of hematological malignancies: clinical implications" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "Z. Chen" 1 => "A.A. Sandberg" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/ajmg.10689" "Revista" => array:6 [ "tituloSerie" => "Am J Med Genet" "fecha" => "2002" "volumen" => "115" "paginaInicial" => "130" "paginaFinal" => "141" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12407693" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Advances in cytogenetic analysis of solid tumors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "L. James" 1 => "J. Varley" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Chromosome Res" "fecha" => "1996" "volumen" => "4" "paginaInicial" => "479" "paginaFinal" => "485" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8939358" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1474442209702996" "estado" => "S300" "issn" => "14744422" ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cytogenetic and interphase FISH analysis of 73 basal cell and three squamous cell carcinoma: different findings in direct preparations and short-term culture" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R. Casalone" 1 => "D. Mazzola" 2 => "R. Righi" 3 => "P. Granata" 4 => "E. Minelli" 5 => "M. Salvadore" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Genet Cytogenet" "fecha" => "2000" "volumen" => "118" "paginaInicial" => "136" "paginaFinal" => "143" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10748294" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nonrandom karyotypic features in squamous cell carcinomas of the skin" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "Y. Jin" 1 => "C. Martins" 2 => "C. Jin" 3 => "L. Salemark" 4 => "N. Jonsson" 5 => "B. Persson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Genes Chromosomes Cancer" "fecha" => "1999" "volumen" => "26" "paginaInicial" => "295" "paginaFinal" => "303" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10534764" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Jumping translocation of chromosome 14 in a skin squamous cell carcinoma from xeroderma pigmentosum patient" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R. Aledo" 1 => "A. Aurias" 2 => "B. Chretein" 3 => "B. Dutrillaux" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Genet Cytogenet" "fecha" => "1988" "volumen" => "33" "paginaInicial" => "29" "paginaFinal" => "33" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3164238" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clonal cytogenetic evolution in a squamous cell carcinoma of the skin from a xeroderma pigmentosum patient" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.J. Worsham" 1 => "T.E. Carey" 2 => "M.S. Benninger" 3 => "K.M. Gasser" 4 => "W. Kelker" 5 => "R.J. Zarbo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Genes Chromosomes Cancer" "fecha" => "1993" "volumen" => "7" "paginaInicial" => "158" "paginaFinal" => "164" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7687869" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Trisomy 7 in keratoacanthoma and squamous cell carcinoma detected by fluorescence in situ hybridization" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.C. Cheville" 1 => "C. Bromley" 2 => "Z.B. Argenyi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Cutan Pathol" "fecha" => "1995" "volumen" => "22" "paginaInicial" => "546" "paginaFinal" => "550" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8835173" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Deletion monitoring in skin tumors by interphase-FISH using band-specific DNA probes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M. Döbler" 1 => "J. Schuh" 2 => "F. Kiesewetter" 3 => "H. Schell" 4 => "T. Liehr" 5 => "E. Gebhart" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int J Oncol" "fecha" => "1999" "volumen" => "14" "paginaInicial" => "571" "paginaFinal" => "576" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10024693" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Kallioniemi" 1 => "O.P. Kallioniemi" 2 => "D. Sudar" 3 => "D. Rutovitz" 4 => "J.W. Gray" 5 => "F. Waldman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Science" "fecha" => "1992" "volumen" => "28" "paginaInicial" => "818" "paginaFinal" => "821" ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chromosomal aberrations in squamous cell carcinoma and solar keratoses revealed by comparative genomic hybridization" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "K.J. Ashton" 1 => "S.R. Weinstein" 2 => "D.J. Maguire" 3 => "L.R. Griffiths" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/archderm.139.7.876" "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "2003" "volumen" => "139" "paginaInicial" => "876" "paginaFinal" => "882" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12873882" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genome-wide detection of chromosomal imbalances in tumors using BAC microarrays" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "W.W. Cai" 1 => "J.H. Mao" 2 => "C.W. Chow" 3 => "S. Damani" 4 => "A. Balmain" 5 => "A. Bradley" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/nbt0402-393" "Revista" => array:7 [ "tituloSerie" => "Nat Biotechnol" "fecha" => "2002" "volumen" => "20" "paginaInicial" => "393" "paginaFinal" => "396" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11923847" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1474442209701395" "estado" => "S300" "issn" => "14744422" ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Microarray-based comparative genomic hybridization and its applications in human genetics" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Oostlander" 1 => "G. Meijer" 2 => "B. Ylstra" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Clin Genet" "fecha" => "2004" "volumen" => "66" "paginaInicial" => "448" "paginaFinal" => "495" ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D.E. Brash" 1 => "J.A. Rudolph" 2 => "J.A. Simon" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Proc Natl Acad Sci US" "fecha" => "1991" "volumen" => "88" "paginaInicial" => "10124" "paginaFinal" => "10128" ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genetic change in actinic keratoses" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "I. Rehman" 1 => "M. Takata" 2 => "Y.-Y. Wu" 3 => "J.L. Rees" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Oncogene" "fecha" => "1996" "volumen" => "12" "paginaInicial" => "2483" "paginaFinal" => "2490" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8700506" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Molecular profiling of transformed and metastatic murine squamous carcinoma cells by differential display and cDNA microarray reveals altered expression of multiple genes related to growth, apoptosis, angiogenesis, and the NF-kB signal pathway" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Dong" 1 => "E. Loukinova" 2 => "Z. Chen" 3 => "L. Gangi" 4 => "T.I. Chanturita" 5 => "E.T. Liu" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Cancer Res" "fecha" => "2001" "volumen" => "15" "paginaInicial" => "4797" "paginaFinal" => "4798" ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Novel proteasome inhibitor PS-341 inhibits activation of NF-kB, cell survival, tumor growth and angiogenesis in squamous cell carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.B. Sunwoo" 1 => "Z. Chen" 2 => "G. Dong" 3 => "N. Yeh" 4 => "C.C. Bancroft" 5 => "E. Sausville" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Cancer Res" "fecha" => "2001" "volumen" => "7" "paginaInicial" => "1419" "paginaFinal" => "1428" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11350913" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mutational analysis of CDKN2A genes in patients with squamous cell carcinoma of the skin" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "Z. Saridaki" 1 => "T. Liloglou" 2 => "A. Zafiropoulos" 3 => "E. Koumantaki" 4 => "O. Zoras" 5 => "D.A. Spandidos" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2003" "volumen" => "148" "paginaInicial" => "638" "paginaFinal" => "648" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12752119" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1474442207701783" "estado" => "S300" "issn" => "14744422" ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genetic imbalances in 26 cases of penile squamous cell carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Alves" 1 => "A. Heller" 2 => "W. Fiedler" 3 => "M.M. Campos" 4 => "U. Claussen" 5 => "A.A. Ornellas" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/gcc.1117" "Revista" => array:6 [ "tituloSerie" => "Genes Chromosomes Cancer" "fecha" => "2001" "volumen" => "31" "paginaInicial" => "48" "paginaFinal" => "53" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11284035" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000009900000003/v1_201304241428/S1578219008702324/v1_201304241428/en/main.assets" "Apartado" => array:4 [ "identificador" => "6155" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original Articles" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000009900000003/v1_201304241428/S1578219008702324/v1_201304241428/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219008702324?idApp=UINPBA000044" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 4 | 11 | 15 |
| 2024 October | 65 | 54 | 119 |
| 2024 September | 64 | 27 | 91 |
| 2024 August | 93 | 52 | 145 |
| 2024 July | 59 | 33 | 92 |
| 2024 June | 76 | 36 | 112 |
| 2024 May | 70 | 43 | 113 |
| 2024 April | 57 | 33 | 90 |
| 2024 March | 48 | 40 | 88 |
| 2024 February | 44 | 41 | 85 |
| 2024 January | 48 | 44 | 92 |
| 2023 December | 42 | 25 | 67 |
| 2023 November | 39 | 39 | 78 |
| 2023 October | 38 | 44 | 82 |
| 2023 September | 42 | 37 | 79 |
| 2023 August | 33 | 42 | 75 |
| 2023 July | 44 | 54 | 98 |
| 2023 June | 40 | 35 | 75 |
| 2023 May | 32 | 23 | 55 |
| 2023 April | 22 | 19 | 41 |
| 2023 March | 18 | 23 | 41 |
| 2023 February | 25 | 15 | 40 |
| 2023 January | 27 | 34 | 61 |
| 2022 December | 23 | 36 | 59 |
| 2022 November | 12 | 30 | 42 |
| 2022 October | 16 | 18 | 34 |
| 2022 September | 17 | 34 | 51 |
| 2022 August | 12 | 14 | 26 |
| 2022 July | 14 | 30 | 44 |
| 2022 June | 22 | 37 | 59 |
| 2022 May | 39 | 57 | 96 |
| 2022 April | 36 | 40 | 76 |
| 2022 March | 43 | 53 | 96 |
| 2022 February | 17 | 30 | 47 |
| 2022 January | 18 | 39 | 57 |
| 2021 December | 18 | 41 | 59 |
| 2021 November | 21 | 39 | 60 |
| 2021 October | 29 | 42 | 71 |
| 2021 September | 35 | 44 | 79 |
| 2021 August | 29 | 21 | 50 |
| 2021 July | 18 | 27 | 45 |
| 2021 June | 12 | 28 | 40 |
| 2021 May | 52 | 35 | 87 |
| 2021 April | 44 | 34 | 78 |
| 2021 March | 63 | 22 | 85 |
| 2021 February | 59 | 25 | 84 |
| 2021 January | 28 | 17 | 45 |
| 2020 December | 25 | 15 | 40 |
| 2020 November | 19 | 14 | 33 |
| 2020 October | 23 | 15 | 38 |
| 2020 September | 22 | 11 | 33 |
| 2020 August | 26 | 14 | 40 |
| 2020 July | 18 | 6 | 24 |
| 2020 June | 23 | 29 | 52 |
| 2020 May | 27 | 18 | 45 |
| 2020 April | 26 | 21 | 47 |
| 2020 March | 26 | 30 | 56 |
| 2020 February | 5 | 5 | 10 |
| 2020 January | 0 | 9 | 9 |
| 2019 December | 0 | 7 | 7 |
| 2019 November | 0 | 3 | 3 |
| 2019 October | 0 | 3 | 3 |
| 2019 September | 0 | 21 | 21 |
| 2019 August | 0 | 2 | 2 |
| 2019 July | 0 | 10 | 10 |
| 2019 June | 0 | 9 | 9 |
| 2019 May | 1 | 51 | 52 |
| 2019 April | 0 | 11 | 11 |
| 2019 March | 0 | 3 | 3 |
| 2019 February | 0 | 8 | 8 |
| 2019 January | 0 | 1 | 1 |
| 2018 December | 0 | 6 | 6 |
| 2018 February | 7 | 6 | 13 |
| 2018 January | 12 | 11 | 23 |
| 2017 December | 17 | 7 | 24 |
| 2017 November | 10 | 5 | 15 |
| 2017 October | 14 | 7 | 21 |
| 2017 September | 10 | 3 | 13 |
| 2017 August | 8 | 6 | 14 |
| 2017 July | 20 | 2 | 22 |
| 2017 June | 22 | 12 | 34 |
| 2017 May | 10 | 2 | 12 |
| 2017 April | 12 | 5 | 17 |
| 2017 March | 13 | 3 | 16 |
| 2017 February | 12 | 6 | 18 |
| 2017 January | 13 | 10 | 23 |
| 2016 December | 17 | 8 | 25 |
| 2016 November | 18 | 19 | 37 |
| 2016 October | 24 | 28 | 52 |
| 2016 September | 25 | 5 | 30 |
| 2016 August | 22 | 4 | 26 |
| 2016 July | 24 | 7 | 31 |
| 2016 June | 17 | 3 | 20 |
| 2016 May | 7 | 5 | 12 |
| 2016 April | 7 | 6 | 13 |
| 2016 March | 3 | 7 | 10 |
| 2016 February | 5 | 10 | 15 |
| 2016 January | 15 | 1 | 16 |
| 2015 December | 10 | 0 | 10 |
| 2015 November | 18 | 2 | 20 |
| 2015 October | 14 | 1 | 15 |
| 2015 September | 7 | 6 | 13 |
| 2015 August | 13 | 2 | 15 |
| 2015 July | 43 | 9 | 52 |
| 2015 June | 56 | 7 | 63 |
| 2015 May | 80 | 13 | 93 |
| 2015 April | 36 | 9 | 45 |
| 2015 March | 29 | 16 | 45 |
| 2015 February | 11 | 11 | 22 |
| 2015 January | 27 | 9 | 36 |
| 2014 December | 29 | 7 | 36 |
| 2014 November | 20 | 14 | 34 |
| 2014 October | 40 | 18 | 58 |
| 2014 September | 30 | 12 | 42 |
| 2014 August | 34 | 22 | 56 |
| 2014 July | 39 | 22 | 61 |
| 2014 June | 62 | 14 | 76 |
| 2014 May | 49 | 25 | 74 |
| 2014 April | 36 | 14 | 50 |
| 2014 March | 47 | 21 | 68 |
| 2014 February | 40 | 11 | 51 |
| 2014 January | 40 | 20 | 60 |
| 2013 December | 53 | 17 | 70 |
| 2013 November | 20 | 14 | 34 |
| 2013 October | 29 | 14 | 43 |
| 2013 September | 29 | 21 | 50 |
| 2013 August | 26 | 38 | 64 |
| 2013 July | 35 | 35 | 70 |
| 2013 June | 27 | 20 | 47 |
| 2013 May | 27 | 17 | 44 |
| 2013 April | 33 | 19 | 52 |
| 2013 March | 31 | 21 | 52 |
| 2013 February | 31 | 16 | 47 |
| 2013 January | 15 | 6 | 21 |
Show all
