Case reports
Waldenström Macroglobulinemia Associated With Cutaneous Lesions and Type I Cryoglobulinemia
Macroglobulinemia de Waldenström Asociada a Lesiones Cutáneas y Crioglobulinemia Tipo IA
J. del Olmoa, A. Españaa,
, M.A. Idoateb, C. Panizoc
Corresponding author
aespana@unav.es
Correspondence: Departamento de Dermatología, Clínica Universitaria de Navarra, Facultat de Medicina, Universidad de Navarra, Apartado 4209 31080 Pamplona, Navarra, Spain.
Correspondence: Departamento de Dermatología, Clínica Universitaria de Navarra, Facultat de Medicina, Universidad de Navarra, Apartado 4209 31080 Pamplona, Navarra, Spain.
a Departamento de Dermatología, Clínica Universitaria de Navarra,Facultad de Medicina, Universidad de Navarra, Pamplona, Navarra, Spain
b Departamento de Anatomía Patológica, Clínica Universitaria de Navarra,Facultad de Medicina, Universidad de Navarra, Pamplona, Navarra, Spain
c Departamento de Hematología, Clínica Universitaria de Navarra,Facultad de Medicina, Universidad de Navarra, Pamplona, Navarra, Spain
Read
7500
Timeswas read the article
3872
Total PDF
3628
Total HTML
Share statistics
array:23 [ "pii" => "S1578219008702142" "issn" => "15782190" "doi" => "10.1016/S1578-2190(08)70214-2" "estado" => "S300" "fechaPublicacion" => "2008-03-01" "aid" => "70214" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "copyrightAnyo" => "2008" "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Actas Dermosifiliogr. 2008;99:138-44" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3460 "formatos" => array:3 [ "EPUB" => 35 "HTML" => 1702 "PDF" => 1723 ] ] "itemSiguiente" => array:18 [ "pii" => "S1578219008702154" "issn" => "15782190" "doi" => "10.1016/S1578-2190(08)70215-4" "estado" => "S300" "fechaPublicacion" => "2008-03-01" "aid" => "70215" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Actas Dermosifiliogr. 2008;99:145-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3008 "formatos" => array:3 [ "EPUB" => 33 "HTML" => 1494 "PDF" => 1481 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>" "titulo" => "Perifollicular Xanthomatosis as a Key Histological Finding in Fox-Fordyce Disease" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "145" "paginaFinal" => "148" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Xantomatosis Perifolicular: Hallazgo Histológico Clave en la Enfermedad de Fox-Fordyce" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. Mataix, J.F. Silvestre, M. Niveiro, A. Lucas, M. Pérez-Crespo" "autores" => array:5 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Mataix" ] 1 => array:2 [ "nombre" => "J.F." "apellidos" => "Silvestre" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "Niveiro" ] 3 => array:2 [ "nombre" => "A." "apellidos" => "Lucas" ] 4 => array:2 [ "nombre" => "M." "apellidos" => "Pérez-Crespo" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219008702154?idApp=UINPBA000044" "url" => "/15782190/0000009900000002/v1_201304241426/S1578219008702154/v1_201304241426/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1578219008702130" "issn" => "15782190" "doi" => "10.1016/S1578-2190(08)70213-0" "estado" => "S300" "fechaPublicacion" => "2008-03-01" "aid" => "70213" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Actas Dermosifiliogr. 2008;99:134-7" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3738 "formatos" => array:3 [ "EPUB" => 35 "HTML" => 1925 "PDF" => 1778 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case reports</span>" "titulo" => "Keratoderma Palmoplantaris Varians (Striata et Areata). A Form of Chronic Idiopathic Acrokeratosis Described by Degos" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "134" "paginaFinal" => "137" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Queratodermia Palmoplantar Varians (<span class="elsevierStyleItalic">Striata Et Areata</span>) Tipo Acroqueratosis Esencial Crónica de Degos" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A. Padial, V. Morales, J.C. Armario-Hita, J.L. Ingunza, J.M. Fernández-Vozmediano" "autores" => array:5 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Padial" ] 1 => array:2 [ "nombre" => "V." "apellidos" => "Morales" ] 2 => array:2 [ "nombre" => "J.C." "apellidos" => "Armario-Hita" ] 3 => array:2 [ "nombre" => "J.L." "apellidos" => "Ingunza" ] 4 => array:2 [ "nombre" => "J.M." "apellidos" => "Fernández-Vozmediano" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219008702130?idApp=UINPBA000044" "url" => "/15782190/0000009900000002/v1_201304241426/S1578219008702130/v1_201304241426/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case reports</span>" "titulo" => "Waldenström Macroglobulinemia Associated With Cutaneous Lesions and Type I Cryoglobulinemia" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "138" "paginaFinal" => "144" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "J. del Olmo, A. España, M.A. Idoate, C. Panizo" "autores" => array:4 [ 0 => array:3 [ "nombre" => "J." "apellidos" => "del Olmo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 1 => array:4 [ "nombre" => "A." "apellidos" => "España" "email" => array:1 [ 0 => "aespana@unav.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 2 => array:3 [ "nombre" => "M.A." "apellidos" => "Idoate" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 3 => array:3 [ "nombre" => "C." "apellidos" => "Panizo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Departamento de Dermatología, Clínica Universitaria de Navarra,Facultad de Medicina, Universidad de Navarra, Pamplona, Navarra, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Departamento de Anatomía Patológica, Clínica Universitaria de Navarra,Facultad de Medicina, Universidad de Navarra, Pamplona, Navarra, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 2 => array:3 [ "entidad" => "Departamento de Hematología, Clínica Universitaria de Navarra,Facultad de Medicina, Universidad de Navarra, Pamplona, Navarra, Spain" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Departamento de Dermatología, Clínica Universitaria de Navarra, Facultat de Medicina, Universidad de Navarra, Apartado 4209 31080 Pamplona, Navarra, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Macroglobulinemia de Waldenström Asociada a Lesiones Cutáneas y Crioglobulinemia Tipo IA" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2007-04-03" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84117" "palabras" => array:2 [ 0 => "Waldenström macroglobulinemia" 1 => "IgM antibodies" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84118" "palabras" => array:2 [ 0 => "macroglobulinemia de Waldenström" 1 => "anticuerpos IgM" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Waldenström macroglobulinemia is a blood dyscrasia characterized by monoclonal proliferation of B cells in the bone marrow, lymph nodes, and spleen. Patients with this disease show elevated serum levels and tissue deposition of monoclonal immunoglobulin (Ig) M produced by these aberrant cells. We present the case of a patient with Waldenström macroglobulinemia who suffered cutaneous lesions resulting from deposition of #k light chains of IgM and clinical manifestations secondary to associated type I cryoglobulinemia. We discuss the different pathological cutaneous processes caused by IgM in Waldenström macroglobulinemia.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">La macroglobulinemia de Waldenström (MW) es una discrasia sanguínea caracterizada por la proliferación monoclonal de células linfoplasmocitarias en la médula ósea, ganglios linfáticos y bazo. Estos pacientes tienen niveles elevados en suero y depósito en tejidos de la inmunoglobulina (Ig) M, de tipo monoclonal, producida por estas células aberrantes. Presentamos el caso de un paciente afecto de MW, con lesiones cutáneas debidas al depósito de cadenas ligeras Kappa de IgM y con manifestaciones clínicas secundarias a la crioglobulinemia tipo I que el paciente tenía asociada. Discutimos los distintos proceso patológicos cutáneos provocados por la IgM en la MW.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:30 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Waldenström's macroglobulinemia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "T.F. Deuel" 1 => "P. Davis" 2 => "L.V. Avioli" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Intern Med" "fecha" => "1983" "volumen" => "143" "paginaInicial" => "2946" "paginaFinal" => "2951" "itemHostRev" => array:3 [ "pii" => "S1474442209702996" "estado" => "S300" "issn" => "14744422" ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous manifestations as initial presentation of Waldenström's macroglobulinemia" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Abdallah-Lotf" 1 => "C. Bourgeois-Droin" 2 => "V. Perronne" 3 => "N. Fouchard" 4 => "S. Michael" 5 => "E. Launay-Russ" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:8 [ "tituloSerie" => "Eur J Dermatol" "fecha" => "2003" "volumen" => "13" "numero" => "1" "paginaInicial" => "90" "paginaFinal" => "92" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12609792" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0140673608610752" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Waldenström's macroglobulinemia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M.A. Dimopoulos" 1 => "R. Alexanian" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Blood" "fecha" => "1994" "volumen" => "83" "paginaInicial" => "1452" "paginaFinal" => "1459" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8123836" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Monoclonal gammopathies and associated skin disorders" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.S. Daoud" 1 => "J.A. Lust" 2 => "R.A. Kyle" 3 => "M.R. Pittelkow" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "1999" "volumen" => "40" "paginaInicial" => "507" "paginaFinal" => "535" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10188670" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Specific cutaneous manifestations of Waldenström's macroglobulinemia: a report of two cases" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.M. Mascaro" 1 => "E. Monserrat" 2 => "T. Estrach" 3 => "E. Feliu" 4 => "J. Ferrando" 5 => "T. Castel" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "1982" "volumen" => "106" "paginaInicial" => "217" "paginaFinal" => "222" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6800395" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous macroglobulinosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C.W. Hanke" 1 => "W.D. Steck" 2 => "W.F. Bergfeld" 3 => "R. Valenzuela" 4 => "J.K. Weick" 5 => "J.R. Young" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "1980" "volumen" => "116" "paginaInicial" => "575" "paginaFinal" => "577" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6769394" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous Waldenström's macroglobulinemia: report of a case and overview of the spectrum of cutaneous disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "L.F. Libow" 1 => "J.P. Mawhinney" 2 => "G.T. Bassinger" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2001" "volumen" => "45" "numero" => "Suppl 6" "paginaInicial" => "S202" "paginaFinal" => "S206" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11712059" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous Waldenström's macroglobulinemia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "I. Chan" 1 => "E. Calonje" 2 => "J. Whittaker" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Exp Dermatol" "fecha" => "2003" "volumen" => "28" "paginaInicial" => "491" "paginaFinal" => "492" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12950334" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Beitrag zur makroglobulinämie Waldenstöm mit kutaner tumormanifestation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "W. Baudach" 1 => "K. Schulz" 2 => "E. Moldenhauer" 3 => "K. Tessmann" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Zschr Inn Med" "fecha" => "1970" "volumen" => "25" "paginaInicial" => "604" "paginaFinal" => "608" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous manifestations of Waldenström's macroglobulinemia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "T. Green" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Br J Dermatol" "fecha" => "1989" "volumen" => "121" "paginaInicial" => "55" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Skin lesions in Waldenström's macroglobulinemia: characterization of the cellular infiltrate" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "V. Bergrouth" 1 => "S. Reitamo" 2 => "Y.T. Konttinen" 3 => "O. Wegelius" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Acta Med Scan" "fecha" => "1981" "volumen" => "209" "paginaInicial" => "129" "paginaFinal" => "131" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous Waldenström's macroglobulinemia: a report of a case successfully treated with radiotherapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "I.F. Orengo" 1 => "A.H. Kettler" 2 => "S. Bruce" 3 => "M.L. Levy" 4 => "T. Rosen" 5 => "J. Tschen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "1987" "volumen" => "60" "paginaInicial" => "1341" "paginaFinal" => "1345" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3113711" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Macular skin lesion and monoclonal lymphoplasmacytoid infiltrates: occurrence in primary Waldenström's macroglobulinemia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "N. Mozzanica" 1 => "A.F. Finzi" 2 => "G. Faccetti" 3 => "M.L. Villa" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "1984" "volumen" => "120" "paginaInicial" => "778" "paginaFinal" => "781" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6426407" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immunchemische untersuchung der paraproteinbildung im hauttumor" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "H.G. Meiers" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1055/s-0028-1110829" "Revista" => array:6 [ "tituloSerie" => "Dtsch Med Wochenschr" "fecha" => "1968" "volumen" => "93" "paginaInicial" => "1795" "paginaFinal" => "1800" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4175143" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous Waldenström's macroglobulinaemia in transformation" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P. Appenzeller" 1 => "C.P. Leith" 2 => "K. Foucar" 3 => "A.A. Scott" 4 => "C.F. Bigler" 5 => "C.T. Thompson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Dermatopathol" "fecha" => "1999" "volumen" => "21" "paginaInicial" => "151" "paginaFinal" => "155" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10218675" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Acquired immunobullous disease: A cutaneous manifestation of IgM macroglobulinemia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S.J. Whitataker" 1 => "B.S. Bhogal" 2 => "M.M. Black" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "1998" "volumen" => "135" "paginaInicial" => "283" "paginaFinal" => "286" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8881675" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bullous pemphigoid due to a 19S monoclonal paraprotein in a patient with Waldenström's (abstract)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "K.D. Wuepper" 1 => "D.J. Key" 2 => "P.J. Kane" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Clin Res" "fecha" => "1978" "volumen" => "26" "paginaInicial" => "579A" "itemHostRev" => array:3 [ "pii" => "S1474442209701395" "estado" => "S300" "issn" => "14744422" ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bullous dermatosis associated with dysglobulinemia (two cases): relationships with epidermolysis bullosa" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Gompel" 1 => "O. Bletry" 2 => "Y. de Prost" 3 => "J. Wechsler" 4 => "B. Wechsler" 5 => "P. Lebon" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Biomed Pharmacother" "fecha" => "1982" "volumen" => "36" "paginaInicial" => "199" "paginaFinal" => "203" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6762227" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A case of acquired autoimmune bullous disease associated with IgM macroglobulinaemia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "E. Morita" 1 => "K. Horiuchi" 2 => "S. Yamamoto" 3 => "T. Hashimoto" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Dermatol" "fecha" => "1999" "volumen" => "26" "paginaInicial" => "671" "paginaFinal" => "676" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10554434" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Examination of cutaneous macroglobulinosis by immunoelectron microscopy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "D. Lipsker" 1 => "B. Cribier" 2 => "N. Boehm" 3 => "E. Heid" 4 => "E. Grosshans" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "1996" "volumen" => "135" "paginaInicial" => "287" "paginaFinal" => "291" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8881676" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Macroglobulinemia cutis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R.E. Tichenor" 1 => "J.M. Rau" 2 => "F.A. Mantz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Arch Dermatol" "fecha" => "1978" "volumen" => "114" "paginaInicial" => "280" "paginaFinal" => "281" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/415666" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1552526007006176" "estado" => "S300" "issn" => "15525260" ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous macroglobulinosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "W. Hanke" 1 => "W.D. Steck" 2 => "W.F. Bergfeld" 3 => "R. Valenzuela" 4 => "J.K. Weick" 5 => "J.R. Young" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "1980" "volumen" => "116" "paginaInicial" => "575" "paginaFinal" => "577" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6769394" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous macroglobulinosis: a case report with unique ultrastructural findings" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "L. Lowe" 1 => "J.E. Fitzpatrick" 2 => "J.C. Huff" 3 => "P.F. Stanley" 4 => "L.E. Golitz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "1992" "volumen" => "128" "paginaInicial" => "377" "paginaFinal" => "380" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1550371" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Waldenström's macroglobulinemia-induced bullous dermatosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "N.Y. West" 1 => "J.E. Fitzpatrick" 2 => "K.M. David-Bajar" 3 => "S.D. Bennion" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "1998" "volumen" => "134" "paginaInicial" => "1127" "paginaFinal" => "1131" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9762027" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Waldenström's macroglobulinemia with an IgM-k antiepidermal membrane zone antibody" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.W. Cobb" 1 => "N. Domloge-Hultsch" 2 => "J.N. Frame" 3 => "K.B. Yancey" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "1992" "volumen" => "128" "paginaInicial" => "372" "paginaFinal" => "376" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1550370" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Schnitzler's syndrome: report a case with progression to Waldenstrom's macroglobulinemia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "B. Welsh" 1 => "B. Tate" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Australas J Dermatol" "fecha" => "1999" "volumen" => "40" "paginaInicial" => "201" "paginaFinal" => "203" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10570556" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Urticarial dermatosis associated with Waldenström's macroglobulinemia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R.M. Pujol" 1 => "M.A. Barnadas" 2 => "S. Brunet" 3 => "J.M. de Moragas" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "1989" "volumen" => "20" "paginaInicial" => "855" "paginaFinal" => "857" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2497159" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Beitrag zur makroglobulinämie Waldenström mit kutaner tumormanifestation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "W. Baudach" 1 => "K. Schulz" 2 => "E. Moldenhauer" 3 => "K. Tessmann" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Zschr Inn Med" "fecha" => "1970" "volumen" => "25" "paginaInicial" => "604" "paginaFinal" => "608" ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Xanthoma disseminatum and Waldenström's macroglobulinemia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M. Goodenberger" 1 => "W.W. Piette" 2 => "D.E. Macfarlane" 3 => "Z.B. Argenyi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "1990" "volumen" => "23" "paginaInicial" => "1015" "paginaFinal" => "1018" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2121806" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "PNP with Waldenström's macroglobulinemia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "G.K. Perera" 1 => "S. Devereux" 2 => "G. Mufti" 3 => "J. Salisbury" 4 => "D. Creamer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2230.2004.01599.x" "Revista" => array:6 [ "tituloSerie" => "Clin Exp Dermatol" "fecha" => "2005" "volumen" => "30" "paginaInicial" => "27" "paginaFinal" => "29" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15663497" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000009900000002/v1_201304241426/S1578219008702142/v1_201304241426/en/main.assets" "Apartado" => array:4 [ "identificador" => "6183" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Case Reports" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000009900000002/v1_201304241426/S1578219008702142/v1_201304241426/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219008702142?idApp=UINPBA000044" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 11 | 18 | 29 |
| 2024 October | 82 | 49 | 131 |
| 2024 September | 83 | 43 | 126 |
| 2024 August | 93 | 70 | 163 |
| 2024 July | 57 | 78 | 135 |
| 2024 June | 67 | 96 | 163 |
| 2024 May | 61 | 43 | 104 |
| 2024 April | 67 | 49 | 116 |
| 2024 March | 61 | 43 | 104 |
| 2024 February | 50 | 63 | 113 |
| 2024 January | 40 | 75 | 115 |
| 2023 December | 43 | 44 | 87 |
| 2023 November | 42 | 43 | 85 |
| 2023 October | 42 | 26 | 68 |
| 2023 September | 33 | 29 | 62 |
| 2023 August | 28 | 38 | 66 |
| 2023 July | 22 | 77 | 99 |
| 2023 June | 36 | 31 | 67 |
| 2023 May | 35 | 29 | 64 |
| 2023 April | 20 | 24 | 44 |
| 2023 March | 22 | 21 | 43 |
| 2023 February | 15 | 36 | 51 |
| 2023 January | 28 | 28 | 56 |
| 2022 December | 29 | 40 | 69 |
| 2022 November | 17 | 33 | 50 |
| 2022 October | 11 | 16 | 27 |
| 2022 September | 15 | 33 | 48 |
| 2022 August | 12 | 40 | 52 |
| 2022 July | 10 | 27 | 37 |
| 2022 June | 15 | 36 | 51 |
| 2022 May | 28 | 42 | 70 |
| 2022 April | 36 | 57 | 93 |
| 2022 March | 33 | 59 | 92 |
| 2022 February | 28 | 34 | 62 |
| 2022 January | 30 | 39 | 69 |
| 2021 December | 15 | 36 | 51 |
| 2021 November | 28 | 44 | 72 |
| 2021 October | 26 | 51 | 77 |
| 2021 September | 23 | 39 | 62 |
| 2021 August | 30 | 26 | 56 |
| 2021 July | 32 | 43 | 75 |
| 2021 June | 22 | 31 | 53 |
| 2021 May | 29 | 29 | 58 |
| 2021 April | 48 | 59 | 107 |
| 2021 March | 68 | 20 | 88 |
| 2021 February | 71 | 33 | 104 |
| 2021 January | 34 | 29 | 63 |
| 2020 December | 18 | 17 | 35 |
| 2020 November | 20 | 18 | 38 |
| 2020 October | 25 | 14 | 39 |
| 2020 September | 23 | 20 | 43 |
| 2020 August | 21 | 27 | 48 |
| 2020 July | 28 | 9 | 37 |
| 2020 June | 19 | 28 | 47 |
| 2020 May | 13 | 20 | 33 |
| 2020 April | 14 | 19 | 33 |
| 2020 March | 14 | 21 | 35 |
| 2020 February | 3 | 13 | 16 |
| 2020 January | 0 | 14 | 14 |
| 2019 December | 0 | 18 | 18 |
| 2019 November | 0 | 4 | 4 |
| 2019 October | 0 | 9 | 9 |
| 2019 September | 0 | 9 | 9 |
| 2019 August | 0 | 5 | 5 |
| 2019 July | 0 | 23 | 23 |
| 2019 June | 0 | 20 | 20 |
| 2019 May | 0 | 137 | 137 |
| 2019 April | 0 | 56 | 56 |
| 2019 March | 0 | 8 | 8 |
| 2019 February | 0 | 11 | 11 |
| 2019 January | 0 | 5 | 5 |
| 2018 November | 0 | 2 | 2 |
| 2018 September | 0 | 5 | 5 |
| 2018 August | 0 | 9 | 9 |
| 2018 July | 0 | 4 | 4 |
| 2018 June | 0 | 1 | 1 |
| 2018 May | 0 | 11 | 11 |
| 2018 April | 0 | 10 | 10 |
| 2018 March | 0 | 8 | 8 |
| 2018 February | 21 | 19 | 40 |
| 2018 January | 28 | 21 | 49 |
| 2017 December | 25 | 21 | 46 |
| 2017 November | 14 | 24 | 38 |
| 2017 October | 17 | 34 | 51 |
| 2017 September | 24 | 23 | 47 |
| 2017 August | 34 | 17 | 51 |
| 2017 July | 22 | 22 | 44 |
| 2017 June | 38 | 68 | 106 |
| 2017 May | 28 | 22 | 50 |
| 2017 April | 30 | 22 | 52 |
| 2017 March | 34 | 53 | 87 |
| 2017 February | 18 | 28 | 46 |
| 2017 January | 18 | 30 | 48 |
| 2016 December | 29 | 12 | 41 |
| 2016 November | 15 | 23 | 38 |
| 2016 October | 28 | 29 | 57 |
| 2016 September | 28 | 18 | 46 |
| 2016 August | 37 | 12 | 49 |
| 2016 July | 36 | 16 | 52 |
| 2016 June | 7 | 9 | 16 |
| 2016 May | 4 | 18 | 22 |
| 2016 April | 8 | 9 | 17 |
| 2016 March | 3 | 11 | 14 |
| 2016 February | 6 | 4 | 10 |
| 2016 January | 10 | 11 | 21 |
| 2015 December | 6 | 7 | 13 |
| 2015 November | 13 | 1 | 14 |
| 2015 October | 4 | 4 | 8 |
| 2015 September | 8 | 2 | 10 |
| 2015 August | 11 | 7 | 18 |
| 2015 July | 22 | 15 | 37 |
| 2015 June | 34 | 12 | 46 |
| 2015 May | 85 | 25 | 110 |
| 2015 April | 51 | 17 | 68 |
| 2015 March | 52 | 24 | 76 |
| 2015 February | 18 | 20 | 38 |
| 2015 January | 29 | 15 | 44 |
| 2014 December | 35 | 26 | 61 |
| 2014 November | 33 | 20 | 53 |
| 2014 October | 27 | 20 | 47 |
| 2014 September | 28 | 22 | 50 |
| 2014 August | 54 | 18 | 72 |
| 2014 July | 38 | 24 | 62 |
| 2014 June | 49 | 16 | 65 |
| 2014 May | 41 | 15 | 56 |
| 2014 April | 32 | 13 | 45 |
| 2014 March | 42 | 22 | 64 |
| 2014 February | 38 | 26 | 64 |
| 2014 January | 33 | 30 | 63 |
| 2013 December | 22 | 20 | 42 |
| 2013 November | 39 | 31 | 70 |
| 2013 October | 34 | 27 | 61 |
| 2013 September | 29 | 26 | 55 |
| 2013 August | 30 | 36 | 66 |
| 2013 July | 34 | 41 | 75 |
| 2013 June | 34 | 37 | 71 |
| 2013 May | 38 | 52 | 90 |
| 2013 April | 29 | 46 | 75 |
| 2013 March | 30 | 33 | 63 |
| 2013 February | 23 | 17 | 40 |
| 2013 January | 15 | 5 | 20 |
Show all
